NETO2

Summary

Gene Symbol: NETO2
Description: neuropilin (NRP) and tolloid (TLL)-like 2
Alias: BTCL2, NEOT2, brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2, neuropilin and tolloid-like protein 2
Species: human

Top Publications

  1. ncbi A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain
    Heidi Stohr
    Institut fur Humangenetik, Biozentrum, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Gene 286:223-31. 2002
  2. ncbi Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2
    Christine E Horak
    Women s Cancer Section, Laboratory of Molecular Pharmacology, National Cancer Institute NIH, 37 Convent Drive, Bethesda, MD 20892, USA
    Cancer Res 67:7238-46. 2007
  3. ncbi Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2/ASF
    Jeremy R Sanford
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    PLoS ONE 3:e3369. 2008
  4. ncbi A transmembrane accessory subunit that modulates kainate-type glutamate receptors
    Wei Zhang
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuron 61:385-96. 2009
  5. ncbi Identification of signaling systems in proliferating and involuting phase infantile hemangiomas by genome-wide transcriptional profiling
    Monica L Calicchio
    Department of Pathology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Am J Pathol 174:1638-49. 2009
  6. ncbi Synaptic targeting and functional modulation of GluK1 kainate receptors by the auxiliary neuropilin and tolloid-like (NETO) proteins
    Bryan A Copits
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 31:7334-40. 2011
  7. ncbi Neto2 modulation of kainate receptors with different subunit compositions
    Christoph Straub
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 31:8078-82. 2011
  8. ncbi Neto1 is an auxiliary subunit of native synaptic kainate receptors
    Man Tang
    Program in Developmental and Stem Cell Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Neurosci 31:10009-18. 2011

Research Grants

  1. Mechanism for Regulating Kainate-Type Glutamate Receptor Activity
    Susumu Tomita; Fiscal Year: 2010
  2. Mechanism for Regulating Kainate-Type Glutamate Receptor Activity
    Susumu Tomita; Fiscal Year: 2011
  3. Genomic analysis of RNA binding protein target specificity
    JEREMY ROBERT SANFORD; Fiscal Year: 2010
  4. Genomic analysis of RNA binding protein target specificity
    JEREMY ROBERT SANFORD; Fiscal Year: 2010

Scientific Experts

  • Christine E Horak
  • Jeremy Sanford
  • Susumu Tomita
  • Christoph Straub
  • Wei Zhang
  • Man Tang
  • Bryan A Copits
  • James R Howe
  • Monica L Calicchio
  • Heidi Stohr
  • Chris J McBain
  • David Ng
  • Kenneth A Pelkey
  • Michael W Salter
  • John S Robbins
  • Shanti Frausto
  • Geoffrey T Swanson
  • Roderick R McInnes
  • Evgueni Ivakine
  • Harry P Kozakewich
  • Fannie St-Gelais
  • Jonathan C Trinidad
  • Chad P Grabner
  • Akio Sumioka
  • Tucker Collins
  • Megumi Morimoto-Tomita
  • Kwang S Kim
  • Alma L Burlingame
  • Susanne Fröhlich
  • Bernhard H F Weber
  • Claudia Berger

Detail Information

Publications8

  1. ncbi A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain
    Heidi Stohr
    Institut fur Humangenetik, Biozentrum, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Gene 286:223-31. 2002
    ..deduced amino acid sequence of a non-annotated nucleotide sequence in the GenBank database, therefore designated NETO2. Both NETO1 and NETO2 share an identical and unique domain structure thus representing a novel subfamily of CUB- ..
  2. ncbi Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2
    Christine E Horak
    Women s Cancer Section, Laboratory of Molecular Pharmacology, National Cancer Institute NIH, 37 Convent Drive, Bethesda, MD 20892, USA
    Cancer Res 67:7238-46. 2007
    ..Nine genes, MET, PTN, SMO, FZD1, L1CAM, MMP2, NETO2, CTGF, and EDG2, were down-regulated by wild-type but not by mutant Nm23-H1 expression...
  3. ncbi Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2/ASF
    Jeremy R Sanford
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    PLoS ONE 3:e3369. 2008
    ..of SF2/ASF regulates the splicing and polysome association of transcripts derived from the SFRS1, PABC1, NETO2 and ENSA genes...
  4. ncbi A transmembrane accessory subunit that modulates kainate-type glutamate receptors
    Wei Zhang
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuron 61:385-96. 2009
    ..Using a proteomic screen, we have identified NETO2, a brain-specific protein of unknown function, as an interactor with kainate-type glutamate receptors...
  5. ncbi Identification of signaling systems in proliferating and involuting phase infantile hemangiomas by genome-wide transcriptional profiling
    Monica L Calicchio
    Department of Pathology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Am J Pathol 174:1638-49. 2009
    ..JAG1), and notch-4 (NOTCH4), as well as genes involved in neural and vascular patterning, such as neuropilin-2 (NETO2), a plexin domain containing receptor (plexinC1), and an ephrin receptor (EPHB3)...
  6. ncbi Synaptic targeting and functional modulation of GluK1 kainate receptors by the auxiliary neuropilin and tolloid-like (NETO) proteins
    Bryan A Copits
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 31:7334-40. 2011
    ..The neuropilin and tolloid-like proteins (NETO) 1 and NETO2, two closely related CUB domain-containing integral membrane proteins, were identified recently as auxiliary ..
  7. ncbi Neto2 modulation of kainate receptors with different subunit compositions
    Christoph Straub
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 31:8078-82. 2011
    ..We recently identified Neuropilin and Tolloid like-2 (Neto2) as a novel accessory subunit of kainate receptors and showed that Neto2 modulates the gating kinetics of GluK2 ..
  8. ncbi Neto1 is an auxiliary subunit of native synaptic kainate receptors
    Man Tang
    Program in Developmental and Stem Cell Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Neurosci 31:10009-18. 2011
    ..In contrast, the loss of Neto2, which also localizes to stratum lucidum and interacts with KARs, had no effect on KAR synaptic abundance or MF-..

Research Grants6

  1. Mechanism for Regulating Kainate-Type Glutamate Receptor Activity
    Susumu Tomita; Fiscal Year: 2010
    ..We have recently identified a novel transmembrane protein, NETO2 that interacts with the kainate receptor, using an unbiased proteomic screen...
  2. Mechanism for Regulating Kainate-Type Glutamate Receptor Activity
    Susumu Tomita; Fiscal Year: 2011
    ..We have recently identified a novel transmembrane protein, NETO2 that interacts with the kainate receptor, using an unbiased proteomic screen...
  3. Genomic analysis of RNA binding protein target specificity
    JEREMY ROBERT SANFORD; Fiscal Year: 2010
    ..2) Determine the genomic landscape of cis-acting RNA elements recognized by SR proteins. (3) Functionally validate SR protein cis-acting RNA elements. ..
  4. Genomic analysis of RNA binding protein target specificity
    JEREMY ROBERT SANFORD; Fiscal Year: 2010
    ..2) Determine the genomic landscape of cis-acting RNA elements recognized by SR proteins. (3) Functionally validate SR protein cis-acting RNA elements. ..