NETO2

Summary

Gene Symbol: NETO2
Description: neuropilin (NRP) and tolloid (TLL)-like 2
Alias: BTCL2, NEOT2, brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2, neuropilin and tolloid-like protein 2
Species: human

Top Publications

  1. ncbi A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain
    Heidi Stohr
    Institut fur Humangenetik, Biozentrum, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Gene 286:223-31. 2002
  2. pmc Formation of chimeric genes by copy-number variation as a mutational mechanism in schizophrenia
    Caitlin Rippey
    Departments of Medicine and of Genome Sciences, University of Washington, Seattle, WA 98195, USA Electronic address
    Am J Hum Genet 93:697-710. 2013
  3. pmc Modulation of homomeric and heteromeric kainate receptors by the auxiliary subunit Neto1
    Janet L Fisher
    J L Fisher USC School of Medicine, Department of Pharmacology, Physiology and Neuroscience, 6439 Garners Ferry Road, Columbia, SC 29209, USA
    J Physiol 591:4711-24. 2013
  4. pmc Neto2 is a KCC2 interacting protein required for neuronal Cl- regulation in hippocampal neurons
    Evgueni A Ivakine
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, ON, Canada M5G 1X8
    Proc Natl Acad Sci U S A 110:3561-6. 2013
  5. pmc Neto2 interacts with the scaffolding protein GRIP and regulates synaptic abundance of kainate receptors
    Man Tang
    Program in Developmental and Stem Cell Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    PLoS ONE 7:e51433. 2012
  6. pmc The auxiliary subunits Neto1 and Neto2 reduce voltage-dependent inhibition of recombinant kainate receptors
    Janet L Fisher
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, South Carolina 29208, USA
    J Neurosci 32:12928-33. 2012
  7. pmc Dancing partners at the synapse: auxiliary subunits that shape kainate receptor function
    Bryan A Copits
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nat Rev Neurosci 13:675-86. 2012
  8. pmc Neto1 and Neto2: auxiliary subunits that determine key properties of native kainate receptors
    Susumu Tomita
    Program in Cellular Neuroscience, Neurodegeneration and Repair CNNR, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Physiol 590:2217-23. 2012
  9. pmc Neto1 is an auxiliary subunit of native synaptic kainate receptors
    Man Tang
    Program in Developmental and Stem Cell Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Neurosci 31:10009-18. 2011
  10. pmc Neto2 modulation of kainate receptors with different subunit compositions
    Christoph Straub
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 31:8078-82. 2011

Scientific Experts

  • Janet L Fisher
  • Susumu Tomita
  • Christine E Horak
  • Jeremy Sanford
  • Man Tang
  • Bryan A Copits
  • Michael W Salter
  • Roderick R McInnes
  • Christoph Straub
  • Wei Zhang
  • Evgueni A Ivakine
  • Caitlin Rippey
  • Vivek Mahadevan
  • David Ng
  • Geoffrey T Swanson
  • Evgueni Ivakine
  • James R Howe
  • Monica L Calicchio
  • Heidi Stohr
  • Michelle Y Huang
  • Mary Claire King
  • Jessica C Pressey
  • Matt Brodsky
  • Bradley P Coe
  • Suleyman Gulsuner
  • Ming K Lee
  • Brooke A Acton
  • Eric Delpire
  • Melanie A Woodin
  • Jonathan Sebat
  • Jake Ormond
  • Alex S Nord
  • Tom Walsh
  • Jon M McClellan
  • Sarah Pierce
  • Niklas Krumm
  • Cailyn Spurrell
  • Molly Gasperini
  • Shanti Frausto
  • Chris J McBain
  • John S Robbins
  • Kenneth A Pelkey
  • Kwang S Kim
  • Harry P Kozakewich
  • Akio Sumioka
  • Jonathan C Trinidad
  • Alma L Burlingame
  • Fannie St-Gelais
  • Tucker Collins
  • Chad P Grabner
  • Megumi Morimoto-Tomita
  • Susanne Fröhlich
  • Bernhard H F Weber
  • Claudia Berger

Detail Information

Publications15

  1. ncbi A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain
    Heidi Stohr
    Institut fur Humangenetik, Biozentrum, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Gene 286:223-31. 2002
    ..deduced amino acid sequence of a non-annotated nucleotide sequence in the GenBank database, therefore designated NETO2. Both NETO1 and NETO2 share an identical and unique domain structure thus representing a novel subfamily of CUB- ..
  2. pmc Formation of chimeric genes by copy-number variation as a mutational mechanism in schizophrenia
    Caitlin Rippey
    Departments of Medicine and of Genome Sciences, University of Washington, Seattle, WA 98195, USA Electronic address
    Am J Hum Genet 93:697-710. 2013
    ..MATK and ZFR2, a 58 kb duplication disrupted PLEKHD1 and SLC39A9, a 121 kb duplication disrupted DNAJA2 and NETO2, and a 150 kb deletion disrupted MAP3K3 and DDX42...
  3. pmc Modulation of homomeric and heteromeric kainate receptors by the auxiliary subunit Neto1
    Janet L Fisher
    J L Fisher USC School of Medicine, Department of Pharmacology, Physiology and Neuroscience, 6439 Garners Ferry Road, Columbia, SC 29209, USA
    J Physiol 591:4711-24. 2013
    ..The neuropilin and tolloid-like 1 and 2 proteins (Neto1 and Neto2) have been recently identified as auxiliary subunits for kainate-type glutamate receptors...
  4. pmc Neto2 is a KCC2 interacting protein required for neuronal Cl- regulation in hippocampal neurons
    Evgueni A Ivakine
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, ON, Canada M5G 1X8
    Proc Natl Acad Sci U S A 110:3561-6. 2013
    ..we show that KCC2 is critically regulated by the single-pass transmembrane protein neuropilin and tolloid like-2 (Neto2)...
  5. pmc Neto2 interacts with the scaffolding protein GRIP and regulates synaptic abundance of kainate receptors
    Man Tang
    Program in Developmental and Stem Cell Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    PLoS ONE 7:e51433. 2012
    ..We have previously identified the single-pass transmembrane proteins, Neto1 and Neto2, to be associated with native KARs...
  6. pmc The auxiliary subunits Neto1 and Neto2 reduce voltage-dependent inhibition of recombinant kainate receptors
    Janet L Fisher
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, South Carolina 29208, USA
    J Neurosci 32:12928-33. 2012
    ..In neurons, kainate receptors can associate with the auxiliary subunits Neto1 or Neto2. These transmembrane proteins alter the trafficking, channel kinetics, and pharmacology of the receptors in a ..
  7. pmc Dancing partners at the synapse: auxiliary subunits that shape kainate receptor function
    Bryan A Copits
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nat Rev Neurosci 13:675-86. 2012
    ..Recently, however, the neuropilin and tolloid-like 1 (NETO1) and NETO2 proteins were identified as auxiliary kainate receptor subunits that shape both the biophysical properties and ..
  8. pmc Neto1 and Neto2: auxiliary subunits that determine key properties of native kainate receptors
    Susumu Tomita
    Program in Cellular Neuroscience, Neurodegeneration and Repair CNNR, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Physiol 590:2217-23. 2012
    ..New research has identified Neto1 and Neto2 as KAR auxiliary subunits that determine unique properties of synaptic KARs, including their slow kinetics and ..
  9. pmc Neto1 is an auxiliary subunit of native synaptic kainate receptors
    Man Tang
    Program in Developmental and Stem Cell Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Neurosci 31:10009-18. 2011
    ..In contrast, the loss of Neto2, which also localizes to stratum lucidum and interacts with KARs, had no effect on KAR synaptic abundance or MF-..
  10. pmc Neto2 modulation of kainate receptors with different subunit compositions
    Christoph Straub
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 31:8078-82. 2011
    ..We recently identified Neuropilin and Tolloid like-2 (Neto2) as a novel accessory subunit of kainate receptors and showed that Neto2 modulates the gating kinetics of GluK2 ..
  11. pmc Synaptic targeting and functional modulation of GluK1 kainate receptors by the auxiliary neuropilin and tolloid-like (NETO) proteins
    Bryan A Copits
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 31:7334-40. 2011
    ..The neuropilin and tolloid-like proteins (NETO) 1 and NETO2, two closely related CUB domain-containing integral membrane proteins, were identified recently as auxiliary ..
  12. pmc Identification of signaling systems in proliferating and involuting phase infantile hemangiomas by genome-wide transcriptional profiling
    Monica L Calicchio
    Department of Pathology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Am J Pathol 174:1638-49. 2009
    ..JAG1), and notch-4 (NOTCH4), as well as genes involved in neural and vascular patterning, such as neuropilin-2 (NETO2), a plexin domain containing receptor (plexinC1), and an ephrin receptor (EPHB3)...
  13. pmc A transmembrane accessory subunit that modulates kainate-type glutamate receptors
    Wei Zhang
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuron 61:385-96. 2009
    ..Using a proteomic screen, we have identified NETO2, a brain-specific protein of unknown function, as an interactor with kainate-type glutamate receptors...
  14. pmc Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2/ASF
    Jeremy R Sanford
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    PLoS ONE 3:e3369. 2008
    ..of SF2/ASF regulates the splicing and polysome association of transcripts derived from the SFRS1, PABC1, NETO2 and ENSA genes...
  15. ncbi Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2
    Christine E Horak
    Women s Cancer Section, Laboratory of Molecular Pharmacology, National Cancer Institute NIH, 37 Convent Drive, Bethesda, MD 20892, USA
    Cancer Res 67:7238-46. 2007
    ..Nine genes, MET, PTN, SMO, FZD1, L1CAM, MMP2, NETO2, CTGF, and EDG2, were down-regulated by wild-type but not by mutant Nm23-H1 expression...

Research Grants9

  1. Mechanism for Regulating Kainate-Type Glutamate Receptor Activity
    Susumu Tomita; Fiscal Year: 2010
    ..We have recently identified a novel transmembrane protein, NETO2 that interacts with the kainate receptor, using an unbiased proteomic screen...
  2. Regulation of glutamate receptors by calcium-dependent protein kinase
    Susumu Tomita; Fiscal Year: 2009
    ..In addition, these studies will contribute to the development of pharmaceutical drugs as cognition enhancers to treat neurodegenerative disease patients including Alzheimer disease, Parkinson's disease and others. ..
  3. Regulation of glutamate receptors by calcium-dependent protein kinase
    Susumu Tomita; Fiscal Year: 2010
    ..In addition, these studies will contribute to the development of pharmaceutical drugs as cognition enhancers to treat neurodegenerative disease patients including Alzheimer disease, Parkinson's disease and others. ..
  4. Mechanism for Regulating Kainate-Type Glutamate Receptor Activity
    Susumu Tomita; Fiscal Year: 2011
    ..We have recently identified a novel transmembrane protein, NETO2 that interacts with the kainate receptor, using an unbiased proteomic screen...
  5. Genomic analysis of RNA binding protein target specificity
    JEREMY ROBERT SANFORD; Fiscal Year: 2010
    ..2) Determine the genomic landscape of cis-acting RNA elements recognized by SR proteins. (3) Functionally validate SR protein cis-acting RNA elements. ..
  6. Genomic analysis of RNA binding protein target specificity
    JEREMY ROBERT SANFORD; Fiscal Year: 2010
    ..2) Determine the genomic landscape of cis-acting RNA elements recognized by SR proteins. (3) Functionally validate SR protein cis-acting RNA elements. ..