Gene Symbol: nestin
Description: nestin
Alias: Nbla00170, nestin
Species: human
Products:     nestin

Top Publications

  1. Gu H, Wang S, Messam C, Yao Z. Distribution of nestin immunoreactivity in the normal adult human forebrain. Brain Res. 2002;943:174-80 pubmed
    The distribution of nestin immunoreactivity was studied in the whole normal adult human forebrains using new anti-human nestin mouse monoclonal and rabbit polyclonal antiserum...
  2. Tamagno I, Schiffer D. Nestin expression in reactive astrocytes of human pathology. J Neurooncol. 2006;80:227-33 pubmed
    There is a general agreement on the Nestin re-expression in reactive astrocytes, but its modalities differ among experimental animal species and between the latter and human material...
  3. Sahlgren C, Pallari H, He T, Chou Y, Goldman R, Eriksson J. A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death. EMBO J. 2006;25:4808-19 pubmed
    The intermediate filament protein, nestin, has been implicated as an organizer of survival-determining signaling molecules...
  4. Amoh Y, Maejima H, Niiyama S, Mii S, Hamada Y, Saito N, et al. Hair follicle stem cell marker nestin expression in regenerating hair follicles of patients with alopecia areata. Eur J Dermatol. 2011;21:209-12 pubmed publisher
    Cells that are nestin positive and keratin 15 (K15) negative are located in the hair follicle pluripotent stem cell (hfPS) area (hfPSA)...
  5. Hockfield S, McKay R. Identification of major cell classes in the developing mammalian nervous system. J Neurosci. 1985;5:3310-28 pubmed
    ..In addition, we report a marker for another cell class present in the developing nervous system, the endothelial cells that give rise to the CNS vasculature. ..
  6. Matsuda Y, Kure S, Ishiwata T. Nestin and other putative cancer stem cell markers in pancreatic cancer. Med Mol Morphol. 2012;45:59-65 pubmed publisher
    ..for pancreatic cancer have been reported, including CD133, CD24, CD44, CXCR4, EpCAM, ABCG2, c-Met, ALDH-1, and nestin, but their use is controversial...
  7. Enache S, Arsene D, Iosif C, Stoicea M, Grigore A, Petrescu A, et al. Nestin and caveolin-1 in the diagnosis of GISTs. Rom J Morphol Embryol. 2012;53:41-6 pubmed
    ..Recently, it was reported that nestin and caveolin-1 are also expressed in some human sarcomas, GISTs included...
  8. Teranishi N, Naito Z, Ishiwata T, Tanaka N, Furukawa K, Seya T, et al. Identification of neovasculature using nestin in colorectal cancer. Int J Oncol. 2007;30:593-603 pubmed
    ..However, this marker detects not only newly formed, but also pre-existing large blood vessels. Nestin, a class VI intermediate filament protein, has recently received attention as a marker for detecting newly formed ..
  9. Wiese C, Rolletschek A, Kania G, Blyszczuk P, Tarasov K, Tarasova Y, et al. Nestin expression--a property of multi-lineage progenitor cells?. Cell Mol Life Sci. 2004;61:2510-22 pubmed
    ..In this review, we describe what is currently known about nestin, an intermediate filament first identified in neuroepithelial stem cells...

More Information


  1. Akiyama Y, Honmou O, Kato T, Uede T, Hashi K, Kocsis J. Transplantation of clonal neural precursor cells derived from adult human brain establishes functional peripheral myelin in the rat spinal cord. Exp Neurol. 2001;167:27-39 pubmed
    ..Sections of removed brain indicated that nestin-positive cells were found predominantly in the subventricular zone around the anterior horns of the lateral ..
  2. Yaworsky P, Kappen C. Heterogeneity of neural progenitor cells revealed by enhancers in the nestin gene. Dev Biol. 1999;205:309-21 pubmed
    ..each requiring the cooperation of at least two independent regulatory sites, within the second intron of the rat nestin gene...
  3. Kawamoto M, Ishiwata T, Cho K, Uchida E, Korc M, Naito Z, et al. Nestin expression correlates with nerve and retroperitoneal tissue invasion in pancreatic cancer. Hum Pathol. 2009;40:189-98 pubmed publisher
    b>Nestin was first described as an intermediate filament protein expressed in neuroepithelial stem cells. Nestin expression has also been reported in brain tumors, schwannomas, gastrointestinal stromal tumors, and melanomas...
  4. Aihara M, Sugawara K, Torii S, Hosaka M, Kurihara H, Saito N, et al. Angiogenic endothelium-specific nestin expression is enhanced by the first intron of the nestin gene. Lab Invest. 2004;84:1581-92 pubmed
    b>Nestin is a member of intermediate filaments abundantly expressed in neural stem cells and glioblastomas. The nestin gene has four exons and three introns, and neural cell-specific expression is regulated by the second intron...
  5. Ishizaki M, Ishiwata T, Adachi A, Tamura N, Ghazizadeh M, Kitamura H, et al. Expression of nestin in rat and human glomerular podocytes. J Submicrosc Cytol Pathol. 2006;38:193-200 pubmed
    b>Nestin is a neuroepithelial precursor cell marker expressed in a variety of human cell types during development. However, no information exists on the expression of nestin in mature glomeruli as well as during the glomerular development...
  6. Chen Z, Wang T, Luo H, Lai Y, Yang X, Li F, et al. Expression of nestin in lymph node metastasis and lymphangiogenesis in non-small cell lung cancer patients. Hum Pathol. 2010;41:737-44 pubmed publisher
    Stem cell marker nestin has been reported to be activated in various neoplasms, and its expression is correlated with poor prognosis. However, nestin expression in non-small cell lung cancer still remains unclear...
  7. Dahlstrand J, Zimmerman L, McKay R, Lendahl U. Characterization of the human nestin gene reveals a close evolutionary relationship to neurofilaments. J Cell Sci. 1992;103 ( Pt 2):589-97 pubmed
    ..gene expression accompany this transition out of the precursor state: transcription of the intermediate filament nestin is replaced by that of the neurofilaments...
  8. Mizuno Y, Takeuchi T, Takatama M, Okamoto K. Expression of nestin in Purkinje cells in patients with Creutzfeldt-Jakob disease. Neurosci Lett. 2003;352:109-12 pubmed
    b>Nestin is one of the intermediate filament proteins and mainly expressed during the development of the central nervous system...
  9. Su H, Weng C, Hsiao P, Chen L, Kuo T, Chen Y, et al. Stem cell marker nestin is critical for TGF-?1-mediated tumor progression in pancreatic cancer. Mol Cancer Res. 2013;11:768-79 pubmed publisher
    The stem cell marker nestin is an intermediate filament protein that plays an important role in cell integrity, migration, and differentiation...
  10. Yamada H, Takano T, Ito Y, Matsuzuka F, Miya A, Kobayashi K, et al. Expression of nestin mRNA is a differentiation marker in thyroid tumors. Cancer Lett. 2009;280:61-4 pubmed publisher
    b>Nestin is a maker that identifies stem cells in some adult tissues, and its expression is believed to relate to malignancy in cancer cells...
  11. Piras F, Perra M, Murtas D, Minerba L, Floris C, Maxia C, et al. The stem cell marker nestin predicts poor prognosis in human melanoma. Oncol Rep. 2010;23:17-24 pubmed
    ..b>Nestin and CD133 have been described as markers of melanocytic stem cells...
  12. Sahlgren C, Mikhailov A, Vaittinen S, Pallari H, Kalimo H, Pant H, et al. Cdk5 regulates the organization of Nestin and its association with p35. Mol Cell Biol. 2003;23:5090-106 pubmed
    The intermediate filament protein nestin is characterized by its specific expression during the development of neuronal and myogenic tissues...
  13. Thomas S, Messam C, Spengler B, Biedler J, Ross R. Nestin is a potential mediator of malignancy in human neuroblastoma cells. J Biol Chem. 2004;279:27994-9 pubmed
    ..Likewise, overexpression of the intermediate filament nestin, a neuroectodermal stem cell marker, is linked to increased aggressiveness in several nervous system tumors...
  14. Mizuno Y, Ohama E, Hirato J, Nakazato Y, Takahashi H, Takatama M, et al. Nestin immunoreactivity of Purkinje cells in Creutzfeldt-Jakob disease. J Neurol Sci. 2006;246:131-7 pubmed
    b>Nestin, an intermediate filament protein, is mainly expressed in neural progenitor/stem cells in the central nervous system. Recently, we reported that nestin is expressed in Purkinje cells in patients with Creutzfeldt-Jakob disease (CJD)...
  15. Parfitt J, McLean C, Joseph M, Streutker C, al Haddad S, Driman D. Granular cell tumours of the gastrointestinal tract: expression of nestin and clinicopathological evaluation of 11 patients. Histopathology. 2006;48:424-30 pubmed
    ..b>Nestin is a recently identified intermediate filament protein that is expressed in neuroectodermal stem cells and ..
  16. Mokry J, Cizkova D, Filip S, Ehrmann J, Osterreicher J, Kolar Z, et al. Nestin expression by newly formed human blood vessels. Stem Cells Dev. 2004;13:658-64 pubmed
    b>Nestin is a type VI intermediate filament protein originally described in neural stem cells. Here we report that immature endothelial cells generated in the course of angiogenesis express nestin...
  17. Ha Y, Lee J, Kim K, Cho Y, Yoon D. Intermediate filament nestin expressions in human cord blood monocytes (HCMNCs). Acta Neurochir (Wien). 2003;145:483-7 pubmed
    b>Nestin is an intermediate protein and a well-known specific neural stem cell antigen. Some bone marrow stem cells can generate not only blood cells but also neurons and glial cells under specific culture conditions...
  18. Sahlgren C, Mikhailov A, Hellman J, Chou Y, Lendahl U, Goldman R, et al. Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase. J Biol Chem. 2001;276:16456-63 pubmed
    The intermediate filament protein nestin is expressed during early stages of development in the central nervous system and in muscle tissues...
  19. Beech R, Cleary M, Treloar H, Eisch A, Harrist A, Zhong W, et al. Nestin promoter/enhancer directs transgene expression to precursors of adult generated periglomerular neurons. J Comp Neurol. 2004;475:128-41 pubmed
    ..In the present study, we used the nestin promoter and enhancer to direct expression of the tetracycline transactivator (tTA)...
  20. Ishiwata T, Teduka K, Yamamoto T, Kawahara K, Matsuda Y, Naito Z. Neuroepithelial stem cell marker nestin regulates the migration, invasion and growth of human gliomas. Oncol Rep. 2011;26:91-9 pubmed publisher
    b>Nestin, a class VI intermediate filament protein, was originally described as a neuronal stem cell marker during central nervous system development...
  21. Liu C, Cao X, Zhang Y, Xu H, Zhang R, Wu Y, et al. Co-expression of Oct-4 and Nestin in human breast cancers. Mol Biol Rep. 2012;39:5875-81 pubmed publisher
    The aim is to investigate the clinical implications of the Oct-4 and Nestin protein in human breast cancers...
  22. Kleeberger W, Bova G, Nielsen M, Herawi M, Chuang A, Epstein J, et al. Roles for the stem cell associated intermediate filament Nestin in prostate cancer migration and metastasis. Cancer Res. 2007;67:9199-206 pubmed
    The intermediate filament protein Nestin identifies stem/progenitor cells in adult tissues, but the function of Nestin is poorly understood. We investigated Nestin expression and function in common lethal cancers...
  23. Ding C, Chen T, Yang Y, Liu S, Yan K, Yue X, et al. Molecular cloning and characterization of an S-adenosylmethionine synthetase gene from Chorispora bungeana. Gene. 2015;572:205-13 pubmed publisher
    ..These results indicated a potential role of CbSAMS in abiotic stresses and plant growth in C. bungeana. ..
  24. Hollborn M, Ulbricht E, Rillich K, Dukic Stefanovic S, Wurm A, Wagner L, et al. The human Müller cell line MIO-M1 expresses opsins. Mol Vis. 2011;17:2738-50 pubmed
    ..protein 2 [MAP2], neurogenic differentiation 1 [NEUROD1], neuronal nuclei [NEUN]), and neural progenitor markers (Nestin [NES], paired-type homeobox transcription factor [PAX6], neurogenic locus notch homolog 1 [NOTCH1])...
  25. Krishnamoorthy R, Athinarayanan J, Periasamy V, Adisa A, Al Shuniaber M, Gassem M, et al. Antimicrobial activity of nanoemulsion on drug-resistant bacterial pathogens. Microb Pathog. 2018;120:85-96 pubmed publisher
    ..The results suggest that the nanoemulsion is effective against DR bacteria, and acts by inhibiting the drug efflux mechanism of DR strains. ..
  26. El Haddad A, Sheta N, Boshra S. Isolation, Formulation, and Efficacy Enhancement of Morin Emulsified Carriers Against Lung Toxicity in Rats. AAPS PharmSciTech. 2018;19:2346-2357 pubmed publisher
    ..SNEDD and NE formulae could ameliorate lung toxicity in a mechanism related to their antioxidant and anti-inflammatory potential. ..
  27. Vijayaraghavan P, Vankayala R, Chiang C, Sung H, Hwang K. Complete destruction of deep-tissue buried tumors via combination of gene silencing and gold nanoechinus-mediated photodynamic therapy. Biomaterials. 2015;62:13-23 pubmed publisher
    ..6 times longer than that (15 days) observed from the anticancer drug doxorubicin-treated group. The current study points out a new direction for the therapeutic design to treat deeply seated tumors in future cancer treatments. ..
  28. Hymowitz G, Salwen J, Salis K. A mediational model of obesity related disordered eating: The roles of childhood emotional abuse and self-perception. Eat Behav. 2017;26:27-32 pubmed publisher
    ..Future studies should investigate the utility of addressing EA and self-perception in interventions for DE and obesity and to determine whether these findings can be generalized to a clinical population. ..
  29. Lai P, Lo Y, Huang M, Hsiao Y, Tsai R. BelSmile: a biomedical semantic role labeling approach for extracting biological expression language from text. Database (Oxford). 2016;2016: pubmed publisher
    ..We also implement a web-based version of BelSmile (iii) that is publicly available at ..
  30. McWilliams A, Reilly C, McFarlane F, Booker E, Heyman I. Nonepileptic seizures in the pediatric population: A qualitative study of patient and family experiences. Epilepsy Behav. 2016;59:128-36 pubmed publisher
    ..Training of health professionals in communicating with young people and families with NES must be improved. ..
  31. Vinci L, Ravarino A, Fanos V, Naccarato A, Senes G, Gerosa C, et al. Immunohistochemical markers of neural progenitor cells in the early embryonic human cerebral cortex. Eur J Histochem. 2016;60:2563 pubmed publisher
    ..Each sample was formalin-fixed, paraffin embedded and immunostained with several markers including GFAP, WT1, Nestin, Vimentin, CD117, S100B, Sox2, PAX2, PAX5, Tβ4, Neurofilament, CD44, CD133, Synaptophysin and Cyclin D1...
  32. Shillito J, Lea J, Tierney S, Cleator J, Tai S, Wilding J. Why I eat at night: A qualitative exploration of the development, maintenance and consequences of Night Eating Syndrome. Appetite. 2018;125:270-277 pubmed publisher
    ..Results have potential to inform future service development, particularly around the adoption of a more holistic approach to night eating behaviours. ..
  33. Hudson J, Chen N, Song S, Walczak P, Jendelova P, Sykova E, et al. Green fluorescent protein bone marrow cells express hematopoietic and neural antigens in culture and migrate within the neonatal rat brain. J Neurosci Res. 2004;76:255-64 pubmed
    ..Recently, it was reported that cultured, unfractionated (whole) adult BM cells form nestin-positive spheres that can later initiate neural differentiation (Kabos et al., 2002)...
  34. Kanoh M, Amoh Y, Tanabe K, Maejima H, Takasu H, Katsuoka K. Nestin is expressed in HMB-45 negative melanoma cells in dermal parts of nodular melanoma. J Dermatol. 2010;37:505-11 pubmed publisher
    b>Nestin, a marker of neural stem cells, is expressed in the stem cells of the mouse hair follicle...
  35. Chrobak A, Siwek G, Siuda Krzywicka K, Arciszewska A, Starowicz Filip A, Siwek M, et al. Neurological and cerebellar soft signs do not discriminate schizophrenia from bipolar disorder patients. Prog Neuropsychopharmacol Biol Psychiatry. 2016;64:96-101 pubmed publisher
    ..We recommend a special focus on those diseases in further research regarding structural and functional changes of cerebellum and their clinical outcome. ..
  36. Chen F, Zhang W, Bi D, Liu W, Wei X, Chen F, et al. Clonal analysis of nestin(-) vimentin(+) multipotent fibroblasts isolated from human dermis. J Cell Sci. 2007;120:2875-83 pubmed
    ..Phenotypic analyses showed that the tripotent fibroblasts were nestin(-) vimentin(+), which is different from the dermis-derived stem cells reported by others...
  37. Walcott J, Provis J. Müller cells express the neuronal progenitor cell marker nestin in both differentiated and undifferentiated human foetal retina. Clin Exp Ophthalmol. 2003;31:246-9 pubmed
    ..Antibodies to nestin (an intermediate filament protein expressed by neural progenitor cells), vimentin, cellular retinaldehyde binding ..
  38. Igartúa D, Calienni M, Feas D, Chiaramoni N, del Valle Alonso S, Prieto M. Development of Nutraceutical Emulsions as Risperidone Delivery Systems: Characterization and Toxicological Studies. J Pharm Sci. 2015;104:4142-4152 pubmed publisher
    ..As all the materials contained in the formulations were US FDA approved, the NE selected would be good candidate for clinical trials. ..
  39. Yang F, Feng S, Lai T, Hu M. A calreticulin-dependent nuclear export signal is involved in the regulation of liver receptor homologue-1 protein folding. Biochem J. 2015;471:199-209 pubmed publisher
    ..Our study demonstrates for the first time that LRH-1 has a CRT-dependent NES which is not only required for cytoplasmic trafficking, but also essential for correct protein folding to avoid misfolding-induced aggregation. ..
  40. McLachlan J, Smith A, Cooper P. Piezo-power microdissection of mature human dental tissue. Arch Oral Biol. 2003;48:731-6 pubmed
    ..Data confirmed that the genes for dentine sialophosphoprotein and Nestin are preferentially expressed in odontoblasts, whilst the genes for both collagen-1alpha and collagen-3alpha were ..
  41. Dailey R, Fontaine C, Avery J. Endocrine response to realimentation in young northern elephant seals (Mirounga angustirostris): Indications for development of fasting adaptation. Gen Comp Endocrinol. 2016;235:130-135 pubmed publisher
    ..Overall, this suggests that the ability to regulate metabolic homeostasis with regards to nutrient allocation may develop over time, even in a species that is considered to be fasting adapted. ..
  42. Sokmensuer L, Sokmensuer C. Nestin expression in neoplastic, fetal, and adult pancreatic endocrine cells. Hepatogastroenterology. 2007;54:2177-80 pubmed
    ..In this study, the expression of nestin in well-differentiated pancreatic neuroendocrine tumors (n = 17) was investigated...
  43. He H, Li M, Niu C. The pathological characteristics of glioma stem cell niches. J Clin Neurosci. 2012;19:121-7 pubmed publisher
    ..We therefore analysed human glioma tissues and found that the CD133(+) and nestin(+) niches are perivascularly localized in all glioma tissues...
  44. Mahboobian M, Seyfoddin A, Rupenthal I, Aboofazeli R, Foroutan S. Formulation Development and Evaluation of the Therapeutic Efficacy of Brinzolamide Containing Nanoemulsions. Iran J Pharm Res. 2017;16:847-857 pubmed
    ..Our findings suggest that NEs could be effectively used as carriers for enhancing the bioavailability of topically applied ophthalmic drugs...
  45. Lu W, Lan F, He Q, Lee A, Tang C, Dong L, et al. Inducible expression of stem cell associated intermediate filament nestin reveals an important role in glioblastoma carcinogenesis. Int J Cancer. 2011;128:343-51 pubmed publisher
    The intermediate filament nestin is transiently expressed in neural stem/progenitor cells during the development of central nervous system...
  46. Liku M, Legere E, Moses A. NoLogo: a new statistical model highlights the diversity and suggests new classes of Crm1-dependent nuclear export signals. BMC Bioinformatics. 2018;19:65 pubmed publisher
    ..Our work questions the practice of assigning each NES to one of several predefined NES classes. Finally, our analysis suggests a novel and testable biophysical perspective on interaction between Crm1 receptor and Crm1-dependent NESs. ..
  47. Pinarbasi E, Cagatay T, Fung H, Li Y, Chook Y, Thomas P. Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization. Sci Rep. 2018;8:7083 pubmed publisher
    ..Together, these results suggest nuclear export of TDP-43 is predominantly driven by passive diffusion. ..
  48. Fung H, Fu S, Chook Y. Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. elife. 2017;6: pubmed publisher
    ..The large conformational range of NES backbones explains the lack of a fixed pattern for its 3-5 hydrophobic anchor residues, which in turn explains the large array of peptide sequences that can function as NESs. ..
  49. Zhong Y, Wang J, Henderson M, Yang P, Hagen B, Siddique T, et al. Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus. elife. 2017;6: pubmed publisher
    ..Our data suggest that SOD1 mutants are removed from the nucleus by CRM1 as a defense mechanism against proteotoxicity of misfolded SOD1 in the nucleus. ..
  50. Wen F, Wu X, Li T, Jia M, Liu X, Li P, et al. Genome-wide survey of heat shock factors and heat shock protein 70s and their regulatory network under abiotic stresses in Brachypodium distachyon. PLoS ONE. 2017;12:e0180352 pubmed publisher
    ..Our genomics analysis of BdHsfs and BdHsp70s provides important evolutionary and functional characterization for further investigation of the accurate regulatory mechanisms among Hsfs and Hsp70s in herbaceous plants. ..
  51. Takahashi K, Ehata S, Koinuma D, Morishita Y, Soda M, Mano H, et al. Pancreatic tumor microenvironment confers highly malignant properties on pancreatic cancer cells. Oncogene. 2018;37:2757-2772 pubmed publisher
    ..The present study thus suggests that both selection and education processes by tumor microenvironment are involved in the development of highly malignant cancer cells. ..
  52. Ahn K, Li C, Lim S, Song H, Ghee J, Kim S, et al. Infiltration of nestin-expressing cells in interstitial fibrosis in chronic cyclosporine nephropathy. Transplantation. 2008;86:571-7 pubmed publisher
    b>Nestin-expressing cells play a role in the repair process of injured tissues and organs. This study examined the nestin-expressing cells in interstitial fibrosis in experimental chronic cyclosporine A (CsA) nephropathy...
  53. Greb Markiewicz B, Sadowska D, Surgut N, Godlewski J, Zarębski M, Ożyhar A. Mapping of the Sequences Directing Localization of the Drosophila Germ Cell-Expressed Protein (GCE). PLoS ONE. 2015;10:e0133307 pubmed publisher
    ..NLSs activity can be modified by juvenile hormone (JH) and other partners, likely 14-3-3 proteins. ..
  54. Yang P, Hernandez M. Purification of astrocytes from adult human optic nerve heads by immunopanning. Brain Res Brain Res Protoc. 2003;12:67-76 pubmed
    ..Purified cells were immunostained with astrocyte markers: GFAP, vimentin, Pax2, A2B5, nestin and NCAM...
  55. Basrai H, Turbic A, Christie K, Turnley A. Suppressor of Cytokine Signalling 2 (SOCS2) Regulates Numbers of Mature Newborn Adult Hippocampal Neurons and Their Dendritic Spine Maturation. Cell Mol Neurobiol. 2017;37:899-909 pubmed publisher
    ..Our results suggest that endogenous SOCS2 regulates numbers of EdU-labelled mature newborn adult hippocampal neurons, possibly by mediating their survival and that this may be via a mechanism regulating dendritic spine maturation. ..
  56. Street C, Lakey J, Seeberger K, Helms L, Rajotte R, Shapiro A, et al. Heterogenous expression of nestin in human pancreatic tissue precludes its use as an islet precursor marker. J Endocrinol. 2004;180:213-25 pubmed
    ..b>Nestin, a marker for neural precursor cells, has been suggested as a possible marker for islet progenitor cells...
  57. Tonthat C, Di Girolamo N. Nestin expression in pterygia: potential role in angiogenesis. Br J Ophthalmol. 2014;98:801-7 pubmed publisher
    ..b>Nestin is a class VI intermediate filament protein expressed in neuroepithelium with an emerging role in angiogenesis and ..
  58. Liu J, Chen W, Ji X, Zheng W, Han W, An J. Correlation of overexpression of nestin with expression of epithelial-mesenchymal transition-related proteins in gastric adenocarcinoma. Asian Pac J Cancer Prev. 2015;16:2777-83 pubmed
    b>Nestin is associated with neoplastic transformation. However, the mechanisms by which nestin contributes regarding invasion and malignancy of gastric adenocarcinoma (GAC) remain unknown...
  59. Misago N, Mori T, Narisawa Y. Nestin expression in stromal cells of trichoblastoma and basal cell carcinoma. J Eur Acad Dermatol Venereol. 2010;24:1354-8 pubmed publisher
    ..and evolving follicular papilla of embryonic hair germs and those cells in hair follicles in early anagen express nestin. The aim of the present study was to investigate whether trichoblastoma and BCC recapitulate the epithelial–..
  60. Zhao Z, Lu P, Zhang H, Xu H, Gao N, Li M, et al. Nestin positively regulates the Wnt/?-catenin pathway and the proliferation, survival and invasiveness of breast cancer stem cells. Breast Cancer Res. 2014;16:408 pubmed publisher
    We investigated Nestin expression in triple-negative breast cancer and examined how the modulation of Nestin expression affects cell cycle progression, survival, invasion and regulatory signaling in breast cancer stem cells (CSC) in vitro...
  61. Ladstein R, Bachmann I, Straume O, Akslen L. Nestin expression is associated with aggressive cutaneous melanoma of the nodular type. Mod Pathol. 2014;27:396-401 pubmed publisher
    The intermediate filament nestin, a neural stem-cell marker, is reported to be expressed more strongly in melanomas compared with benign melanocytic lesions, and increasingly expressed in advanced melanoma stages...
  62. Lv D, Lu L, Hu Z, Fei Z, Liu M, Wei L, et al. Nestin Expression Is Associated with Poor Clinicopathological Features and Prognosis in Glioma Patients: an Association Study and Meta-analysis. Mol Neurobiol. 2017;54:727-735 pubmed publisher
    b>Nestin has been identified as a molecular marker of neural progenitor cells and putative glioma stem cells (GSCs)...
  63. Messam C, Hou J, Berman J, Major E. Analysis of the temporal expression of nestin in human fetal brain derived neuronal and glial progenitor cells. Brain Res Dev Brain Res. 2002;134:87-92 pubmed
    b>Nestin expression in the developing human brain was examined with the use of unique human specific anti-nestin antibodies...
  64. Schrenk C, Fetz V, Vallet C, Heiselmayer C, Schröder E, Hensel A, et al. TFIIA transcriptional activity is controlled by a 'cleave-and-run' Exportin-1/Taspase 1-switch. J Mol Cell Biol. 2017;:1-15 pubmed publisher
    ..We here identified a novel mechanism how proteolysis and nuclear transport cooperatively fine-tune transcriptional programs...
  65. Liu G, Liu J, He Z, Wang F, Yang H, Yan Y, et al. Implementation of CsLIS/NES in linalool biosynthesis involves transcript splicing regulation in Camellia sinensis. Plant Cell Environ. 2017;: pubmed publisher
  66. Sen V, Bozkurt O, Demir O, Tuna B, Yorukoglu K, Ellidokuz H, et al. Prognostic significance of Nestin expression in pT1 high- grade bladder urothelial carcinoma patients treated with intravesical BCG. Asian Pac J Cancer Prev. 2014;15:10813-7 pubmed
    Possible roles of nestin expression in terms of predicting intravesical BCG therapy response in T1 high grade bladder cancer patients were investigated...
  67. Tschaharganeh D, Xue W, Calvisi D, Evert M, Michurina T, Dow L, et al. p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer. Cell. 2014;158:579-92 pubmed publisher
    ..Here, we show that p53 restricts expression of the stem and progenitor-cell-associated protein nestin in an Sp1/3 transcription-factor-dependent manner and that Nestin is required for tumor initiation in vivo...
  68. Chen P, Chen W, Li J, Lind A, Lu D. Diagnostic utility of neural stem and progenitor cell markers nestin and SOX2 in distinguishing nodal melanocytic nevi from metastatic melanomas. Mod Pathol. 2013;26:44-53 pubmed publisher
    ..Recent studies have demonstrated strong expression of neural stem/progenitor cell markers nestin and SOX2 in melanoma...
  69. Kirik O, Korzhevskii D. Expression of neural stem cell marker nestin in the kidney of rats and humans. Bull Exp Biol Med. 2009;147:539-41 pubmed
    b>Nestin is present in podocytes of the renal corpuscle in rats and humans. Specific differences manifested in more intensive and widespread expression of nestin by endothelial cells of blood vessels in human kidney.
  70. Minovi A, Witt M, Prescher A, Gudziol V, Dazert S, Hatt H, et al. Expression and distribution of the intermediate filament protein nestin and other stem cell related molecules in the human olfactory epithelium. Histol Histopathol. 2010;25:177-87 pubmed publisher
    ..The nestin protein was shown to be expressed in the OE of rodents and is suggested to be essentially involved in the process ..
  71. Walczak P, Chen N, Hudson J, Willing A, Garbuzova Davis S, Song S, et al. Do hematopoietic cells exposed to a neurogenic environment mimic properties of endogenous neural precursors?. J Neurosci Res. 2004;76:244-54 pubmed
    ..A few cells, identified by using human-specific antibodies (anti-human nuclei, or mitochondria) expressed nestin and doublecortin, markers of endogenous neural progenitors...
  72. Küpper A, Peter F, Zöllner P, Lorentz L, Tranel P, Beffa R, et al. Tembotrione detoxification in 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor-resistant Palmer amaranth (Amaranthus palmeri S. Wats.). Pest Manag Sci. 2018;74:2325-2334 pubmed publisher
    ..2017 Society of Chemical Industry. ..
  73. McLachlan J, Smith A, Sloan A, Cooper P. Gene expression analysis in cells of the dentine-pulp complex in healthy and carious teeth. Arch Oral Biol. 2003;48:273-83 pubmed
    ..previously shown to be preferentially expressed in odontoblasts, namely dentin sialophosphoprotein (DSPP) and Nestin, amplified more readily from the extracted pulp-odontoblast complex, as compared to pulpal tissue alone, in both ..
  74. Qin Q, Sun Y, Fei M, Zhang J, Jia Y, Gu M, et al. Expression of putative stem marker nestin and CD133 in advanced serous ovarian cancer. Neoplasma. 2012;59:310-5 pubmed publisher
    ..Expression of two putative stem cell markers CD133 and nestin, and vascular epithelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) were detected in 123 ..
  75. Qendro V, Lundgren D, Rezaul K, Mahony F, Ferrell N, Bi A, et al. Large-scale proteomic characterization of melanoma expressed proteins reveals nestin and vimentin as biomarkers that can potentially distinguish melanoma subtypes. J Proteome Res. 2014;13:5031-40 pubmed publisher
    ..of each melanoma cell line and literature mining resulted in the final selection of six proteins: vimentin, nestin, fibronectin, annexin A1, dipeptidyl peptidase IV, and histone H2A1B...
  76. Geliebter A, McOuatt H, Tetreault C, Kordunova D, Rice K, Zammit G, et al. Is night eating syndrome associated with obstructive sleep apnea, BMI, and depressed mood in patients from a sleep laboratory study?. Eat Behav. 2016;23:115-119 pubmed publisher
    ..81, p<0.001). We found that NES was not associated with BMI or AHI severity. The findings show that NES is primarily an eating disorder, rather than a sleep disorder, and that there is an association between NES and depressed mood. ..
  77. Wu B, Sun C, Feng F, Ge M, Xia L. Do relevant markers of cancer stem cells CD133 and Nestin indicate a poor prognosis in glioma patients? A systematic review and meta-analysis. J Exp Clin Cancer Res. 2015;34:44 pubmed publisher
    CD133 and Nestin, as the markers of cancer stem cells, have recently been reported frequently in the pathogenesis and development of human gliomas. However, the prognostic role of CD133 and Nestin in gliomas still remains controversial...
  78. Thakurta A, Gopal G, Yoon J, Saha T, Dhar R. Conserved nuclear export sequences in Schizosaccharomyces pombe Mex67 and human TAP function in mRNA export by direct nuclear pore interactions. J Biol Chem. 2004;279:17434-42 pubmed
    ..pombe strain, suggesting that the NESs can function in the absence of p15. These novel nuclear export sequences may provide additional routes for delivering Mex67/TAP to the nuclear pore complex...
  79. Ryuge S, Sato Y, Nagashio R, Hiyoshi Y, Katono K, Igawa S, et al. Prognostic significance of nestin expression in patients with resected non-small cell lung cancer treated with platinum-based adjuvant chemotherapy; relationship between nestin expression and epithelial to mesenchymal transition related markers. PLoS ONE. 2017;12:e0173886 pubmed publisher
    ..b>Nestin is a class VI intermediate filament protein expressed in neural stem cells and several cancer cells including ..
  80. Tapancı Z, Yildirim A, Boysan M. Neurological soft signs, dissociation and alexithymia in patients with obsessive-compulsive disorder (OCD) and healthy subjects. Psychiatry Res. 2018;260:90-97 pubmed publisher
    ..We concluded that relationships between OCD severity and NSS appear to be of crucial importance. Our data along with accumulated evidence suggest that OCD associated with pronounced NSS may represent a specific subtype of the disorder. ..
  81. Pinho S, LaCombe J, Hanoun M, Mizoguchi T, Bruns I, Kunisaki Y, et al. PDGFR? and CD51 mark human nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion. J Exp Med. 2013;210:1351-67 pubmed publisher
    The intermediate filament protein Nestin labels populations of stem/progenitor cells, including self-renewing mesenchymal stem cells (MSCs), a major constituent of the hematopoietic stem cell (HSC) niche...
  82. Onisim A, Iancu M, Vlad C, Kubelac P, Fetica B, Fulop A, et al. Expression of Nestin and CD133 in serous ovarian carcinoma. J BUON. 2016;21:1168-1175 pubmed
    Pupose: Nestin and CD133 are regarded as putative markers of cancer stem cells (CSCs) and related to poor prognosis in various cancer sites...
  83. Kodet O, Dvořánková B, Krejci E, Szabo P, Dvorak P, Stork J, et al. Cultivation-dependent plasticity of melanoma phenotype. Tumour Biol. 2013;34:3345-55 pubmed publisher
    ..only constantly present diagnostic marker observed in our experiment was S100 protein and, in lesser extent, also Nestin. The phenotype loss was reverted under the influence of melanoma-associated fibroblast and/or both types of ..
  84. Corfield P, Kershaw R. Crystal structures of two bi-cyclo-[5.1.0]octa-nes: potassium trans-bi-cyclo-[5.1.0]octane-4-carboxyl-ate monohydrate and cis-bi-cyclo-[5.1.0]octan-4-yl 4-bromo-benzene-sulfonate. Acta Crystallogr E Crystallogr Commun. 2017;73:1357-1362 pubmed publisher
    ..The bicyclic ring system of (I) is disordered across a crystallographic mirror plane. The geometries of the cis-fused and trans-fused ring systems are compared...
  85. Wang J, Pavlyk I, Vedula P, Sterling S, Leu N, Dong D, et al. Arginyltransferase ATE1 is targeted to the neuronal growth cones and regulates neurite outgrowth during brain development. Dev Biol. 2017;430:41-51 pubmed publisher
    ..and neuronal growth by producing a conditional mouse knockout with Ate1 deletion in the nervous system driven by Nestin promoter (Nes-Ate1 mice)...
  86. Nishikawa M, Mori H, Hara M. Analysis of ZIP (Zrt-, Irt-related protein) transporter gene expression in murine neural stem/progenitor cells. Environ Toxicol Pharmacol. 2017;53:81-88 pubmed publisher
    ..We considered that required types of ZIP changed during the differetiation of NSPCs. ..
  87. Hatanpaa K, Hu T, Vemireddy V, Foong C, Raisanen J, Oliver D, et al. High expression of the stem cell marker nestin is an adverse prognostic factor in WHO grade II-III astrocytomas and oligoastrocytomas. J Neurooncol. 2014;117:183-189 pubmed publisher
    ..In this study, we evaluated the prognostic and predictive value of the stem cell marker nestin in adult A+OA II-III (n = 50) using immunohistochemistry and computer-assisted analysis on tissue microarrays...