nephrin

Summary

Gene Symbol: nephrin
Description: NPHS1, nephrin
Alias: CNF, NPHN, nephrin, nephrin, nephrosis 1, congenital, Finnish type (nephrin), renal glomerulus-specific cell adhesion receptor, truncated NPHS1
Species: human
Products:     nephrin

Top Publications

  1. Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, et al. Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1. J Biol Chem. 2009;284:8951-62 pubmed publisher
    ..b>Nephrin, the major component of the SD, is tyrosine-phosphorylated by a Src family tyrosine kinase, Fyn, in developing or ..
  2. Toyoda M, Suzuki D, Umezono T, Uehara G, Maruyama M, Honma M, et al. Expression of human nephrin mRNA in diabetic nephropathy. Nephrol Dial Transplant. 2004;19:380-5 pubmed
    ..b>Nephrin is a novel podocyte-specific protein which localizes at the slit diaphragm...
  3. Ren S, Xin C, Beck K, Saleem M, Mathieson P, Pavenstadt H, et al. PPARalpha activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism. Biochem Biophys Res Commun. 2005;338:1818-24 pubmed
    b>Nephrin is an important member of the glomerular ultrafiltration complex and changes in its expression are associated with severe proteinuria...
  4. Verma R, Wharram B, Kovari I, Kunkel R, Nihalani D, Wary K, et al. Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin. J Biol Chem. 2003;278:20716-23 pubmed
    ..the molecular components of the podocyte intercellular junction, because several of these components, including Nephrin, are functionally necessary for development of normal podocyte structure and filter integrity...
  5. Benigni A, Gagliardini E, Tomasoni S, Abbate M, Ruggenenti P, Kalluri R, et al. Selective impairment of gene expression and assembly of nephrin in human diabetic nephropathy. Kidney Int. 2004;65:2193-200 pubmed
    ..Here we addressed the role of nephrin, CD2-associated protein (CD2AP), and podocin together with the integrity of the slit diaphragm in the ..
  6. Holthofer H, Ahola H, Solin M, Wang S, Palmen T, Luimula P, et al. Nephrin localizes at the podocyte filtration slit area and is characteristically spliced in the human kidney. Am J Pathol. 1999;155:1681-7 pubmed
    ..Together with its gene product, nephrin, NPHS1 is providing new understanding of the pathophysiological mechanisms of glomerular filtration...
  7. Sohn R, Huang P, Kawahara G, Mitchell M, Guyon J, Kalluri R, et al. A role for nephrin, a renal protein, in vertebrate skeletal muscle cell fusion. Proc Natl Acad Sci U S A. 2009;106:9274-9 pubmed publisher
    ..Sticks and stones (Sns), a cell surface protein found on Drosophila myoblasts, has structural homology to nephrin. Nephrin is a protein expressed in kidney that is part of the filtration barrier formed by podocytes...
  8. Garg P, Verma R, Nihalani D, Johnstone D, Holzman L. Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization. Mol Cell Biol. 2007;27:8698-712 pubmed
    ..The kidney podocyte provides a unique model for investigating these mechanisms since deletion of Nephrin or Neph1, two interacting components of the specialized podocyte intercellular junction, results in abnormal ..
  9. Liu G, Kaw B, Kurfis J, Rahmanuddin S, Kanwar Y, Chugh S. Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability. J Clin Invest. 2003;112:209-21 pubmed
    ..microscopy in rodents and describe its direct interaction with two other components of the slit diaphragm, nephrin and ZO-1...

More Information

Publications86

  1. Lahdenperä J, Kilpeläinen P, Liu X, Pikkarainen T, Reponen P, Ruotsalainen V, et al. Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases. Kidney Int. 2003;64:404-13 pubmed
    b>Nephrin is a recently discovered protein of the immunoglobulin (Ig) superfamily...
  2. Doublier S, Salvidio G, Lupia E, Ruotsalainen V, Verzola D, Deferrari G, et al. Nephrin expression is reduced in human diabetic nephropathy: evidence for a distinct role for glycated albumin and angiotensin II. Diabetes. 2003;52:1023-30 pubmed
    We studied the distribution of nephrin in renal biopsies from 17 patients with diabetes and nephrotic syndrome (7 type 1 and 10 type 2 diabetes), 6 patients with diabetes and microalbuminuria (1 type 1 and 5 type 2 diabetes), and 10 ..
  3. Quack I, Rump L, Gerke P, Walther I, Vinke T, Vonend O, et al. beta-Arrestin2 mediates nephrin endocytosis and impairs slit diaphragm integrity. Proc Natl Acad Sci U S A. 2006;103:14110-5 pubmed
    beta-Arrestins mediate internalization of plasma membrane receptors. Nephrin, a structural component of the glomerular slit diaphragm, is a single transmembrane spanning receptor and belongs to the family of adhesion molecules...
  4. Jones N, Blasutig I, Eremina V, Ruston J, Bladt F, Li H, et al. Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature. 2006;440:818-23 pubmed
    ..Mutations affecting a number of slit diaphragm proteins, including nephrin (encoded by NPHS1), lead to renal disease owing to disruption of the filtration barrier and rearrangement of the ..
  5. Ruotsalainen V, Ljungberg P, Wartiovaara J, Lenkkeri U, Kestila M, Jalanko H, et al. Nephrin is specifically located at the slit diaphragm of glomerular podocytes. Proc Natl Acad Sci U S A. 1999;96:7962-7 pubmed
    We describe here the size and location of nephrin, the first protein to be identified at the glomerular podocyte slit diaphragm...
  6. Blasutig I, New L, Thanabalasuriar A, Dayarathna T, Goudreault M, Quaggin S, et al. Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization. Mol Cell Biol. 2008;28:2035-46 pubmed publisher
    ..The nephrin adhesion protein is essential for the formation of actin-based foot processes in glomerular podocytes...
  7. Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, et al. Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2. J Biol Chem. 2008;283:9177-86 pubmed publisher
    ..Several SD components including nephrin and TRPC6 are known to be phosphorylated by a Src family tyrosine kinase (SFK), Fyn...
  8. Fornoni A, Jeon J, Varona Santos J, Cobianchi L, Jauregui A, Inverardi L, et al. Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release. Diabetes. 2010;59:190-9 pubmed publisher
    b>Nephrin, an immunoglobulin-like protein essential for the function of the glomerular podocyte and regulated in diabetic nephropathy, is also expressed in pancreatic beta-cells, where its function remains unknown...
  9. Schwarz K, Simons M, Reiser J, Saleem M, Faul C, Kriz W, et al. Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin. J Clin Invest. 2001;108:1621-9 pubmed
    ..reveal that podocin associates via its COOH-terminal domain with CD2AP, a cytoplasmic binding partner of nephrin, and with nephrin itself...
  10. Coward R, Foster R, Patton D, Ni L, Lennon R, Bates D, et al. Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes. J Am Soc Nephrol. 2005;16:629-37 pubmed
    ..in maintaining the filtration barrier of the glomerulus and are dependent on the slit diaphragm (SD) proteins nephrin, podocin, and CD2-associated protein (CD2AP) to function optimally...
  11. Khoshnoodi J, Sigmundsson K, Ofverstedt L, Skoglund U, Obrink B, Wartiovaara J, et al. Nephrin promotes cell-cell adhesion through homophilic interactions. Am J Pathol. 2003;163:2337-46 pubmed
    b>Nephrin is a type-1 transmembrane protein and a key component of the podocyte slit diaphragm, the ultimate glomerular plasma filter...
  12. Gerke P, Huber T, Sellin L, Benzing T, Walz G. Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1. J Am Soc Nephrol. 2003;14:918-26 pubmed
    b>Nephrin and NEPH1, the gene products of NPHS1 and NEPH1, are podocyte membrane proteins of the Ig superfamily. Similar to the nephrin knockout, mice lacking NEPH1 show severe proteinuria leading to perinatal death...
  13. Huber T, Kottgen M, Schilling B, Walz G, Benzing T. Interaction with podocin facilitates nephrin signaling. J Biol Chem. 2001;276:41543-6 pubmed
    Mutations of NPHS1 or NPHS2, the genes encoding for the glomerular podocyte proteins nephrin and podocin, cause steroid-resistant proteinuria...
  14. Palmen T, Ahola H, Palgi J, Aaltonen P, Luimula P, Wang S, et al. Nephrin is expressed in the pancreatic beta cells. Diabetologia. 2001;44:1274-80 pubmed
    The NPHS1 gene product, nephrin, is a crucial component of the glomerular filtration barrier preventing proteinuria and previously assumed to be kidney-specific...
  15. Hartleben B, Schweizer H, Lübben P, Bartram M, Möller C, Herr R, et al. Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. J Biol Chem. 2008;283:23033-8 pubmed publisher
    ..We now identify Par3, Par6, and atypical protein kinase C (aPKC) polarity proteins as novel Neph1-Nephrin-associated proteins...
  16. Saleem M, Ni L, Witherden I, Tryggvason K, Ruotsalainen V, Mundel P, et al. Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation. Am J Pathol. 2002;161:1459-66 pubmed
    The discovery of the genes for nephrin and podocin, which are mutated in two types of congenital nephrotic syndrome, was pivotal in establishing the podocyte as the central component of the glomerular filtration barrier...
  17. Kestila M, Lenkkeri U, Männikkö M, Lamerdin J, McCready P, Putaala H, et al. Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome. Mol Cell. 1998;1:575-82 pubmed
    ..The NPHS1 gene product, termed nephrin, is a 1241-residue putative transmembrane protein of the immunoglobulin family of cell adhesion molecules, which ..
  18. Venkatareddy M, Cook L, Abuarquob K, Verma R, Garg P. Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin. PLoS ONE. 2011;6:e28710 pubmed publisher
    Actin dynamics has emerged at the forefront of podocyte biology. Slit diaphragm junctional adhesion protein Nephrin is necessary for development of the podocyte morphology and transduces phosphorylation-dependent signals that regulate ..
  19. Quack I, Woznowski M, Potthoff S, Palmer R, Königshausen E, Sivritas S, et al. PKC alpha mediates beta-arrestin2-dependent nephrin endocytosis in hyperglycemia. J Biol Chem. 2011;286:12959-70 pubmed publisher
    b>Nephrin, the key molecule of the glomerular slit diaphragm, is expressed on the surface of podocytes and is critical in preventing albuminuria...
  20. Langham R, Kelly D, Cox A, Thomson N, Holthofer H, Zaoui P, et al. Proteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: effects of angiotensin converting enzyme inhibition. Diabetologia. 2002;45:1572-6 pubmed
    ..b>Nephrin, a 1241-residue transmembrane protein is a key component of the podocyte slit pore membrane and a major ..
  21. Coward R, Welsh G, Koziell A, Hussain S, Lennon R, Ni L, et al. Nephrin is critical for the action of insulin on human glomerular podocytes. Diabetes. 2007;56:1127-35 pubmed
    ..We now show that the podocyte protein nephrin is essential for this process...
  22. Liu X, Kilpeläinen P, Hellman U, Sun Y, Wartiovaara J, Morgunova E, et al. Characterization of the interactions of the nephrin intracellular domain. FEBS J. 2005;272:228-43 pubmed
    b>Nephrin is a signalling cell-cell adhesion protein of the Ig superfamily and the first identified component of the slit diaphragm that forms the critical and ultimate part of the glomerular ultrafiltration barrier...
  23. Verma R, Kovari I, Soofi A, Nihalani D, Patrie K, Holzman L. Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization. J Clin Invest. 2006;116:1346-59 pubmed
    ..The observation that mutation or deletion of the slit diaphragm transmembrane protein nephrin results in failure of podocyte foot process morphogenesis and concomitant proteinuria first suggested the ..
  24. Lehtonen S, Lehtonen E, Kudlicka K, Holthofer H, Farquhar M. Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin. Am J Pathol. 2004;165:923-36 pubmed
    Mutations in the NPHS1 gene encoding nephrin lead to congenital nephrotic syndrome of the Finnish type...
  25. Ma R, Jiang W, Li Z, Sun Y, Wei Z. Intrarenal macrophage infiltration induced by T cells is associated with podocyte injury in lupus nephritis patients. Lupus. 2016;25:1577-1586 pubmed
    ..Histological changes in LN patients were detected by light and electron microscopy. Podocyte-specific nephrin expression in renal tissues was detected by immunofluorescence...
  26. Yang J, Xu F, Han C. Metal Ion Mediated Cellulose Nanofibrils Transient Network in Covalently Cross-linked Hydrogels: Mechanistic Insight into Morphology and Dynamics. Biomacromolecules. 2017;18:1019-1028 pubmed publisher
    ..The cations promote the formation of porous networks of nanofibrils by screening the repulsive negative charges on CNF surface and dominate the mechanical properties and self-recovery efficiency of the hydrogels, resulting in ..
  27. Yamakawa A, Suzuki S, Oku T, Enomoto K, Ikeda M, Rodrigue J, et al. Nanostructure and physical properties of cellulose nanofiber-carbon nanotube composite films. Carbohydr Polym. 2017;171:129-135 pubmed publisher
    We studied the nanostructure and physical properties of cellulose nanofiber-multi-walled carbon nanotube (CNF-MWNT) composite films prepared via MWNT aqueous dispersion using 4-O-methyl-?-d-glucuronoxylan as a MWNT dispersion aid...
  28. Betancourth Alvarenga J, Garrido Pérez J, Castillo Fernández A, Murcia Pascual F, Cárdenas Elias M, Escassi Gil A, et al. [Management of gastroesophageal reflux in children. Single centre experience in conventional and laparoscopic Nissen fundoplication in the last 15 years]. An Pediatr (Barc). 2017;86:220-225 pubmed publisher
    ..LNF) is safe, with low morbidity and high success rate, although some cases require a conventional approach (CNF). The aim of the study is to compare the results between LNF and CNF in our centre...
  29. Jin H, Chen L, Zhang Z, Xu Y, Song B, Xu R, et al. Deletion of angiotensin-converting enzyme 2 exacerbates renal inflammation and injury in apolipoprotein E-deficient mice through modulation of the nephrin and TNF-alpha-TNFRSF1A signaling. J Transl Med. 2015;13:255 pubmed publisher
    ..Downregulation of ACE2 and nephrin levels was observed in ApoEKO kidneys...
  30. Xu X, Zhou J, Jiang L, Lubineau G, Ng T, Ooi B, et al. Highly transparent, low-haze, hybrid cellulose nanopaper as electrodes for flexible electronics. Nanoscale. 2016;8:12294-306 pubmed publisher
    ..By varying the CNC/CNF ratio in the hybrid CNP, we could tailor its total transmittance, direct transmittance and diffuse transmittance...
  31. Bruggeman L, Wu Z, Luo L, Madhavan S, Konieczkowski M, Drawz P, et al. APOL1-G0 or APOL1-G2 Transgenic Models Develop Preeclampsia but Not Kidney Disease. J Am Soc Nephrol. 2016;27:3600-3610 pubmed
    ..Because APOL1 is unique to humans and some primates, we created transgenic (Tg) mice using the promoter of nephrin-encoding Nphs1 to express the APOL1 reference sequence (G0) or the G2 risk variant in podocytes, establishing Tg ..
  32. You H, Gao T, Cooper T, Morris S, Awad A. Arginase inhibition: a new treatment for preventing progression of established diabetic nephropathy. Am J Physiol Renal Physiol. 2015;309:F447-55 pubmed publisher
    ..changes, kidney macrophage infiltration, urinary thiobarbituric acid-reactive substances, and restored nephrin expression, kidney nitrate/nitrite, kidney endothelial nitric oxide synthase phosphorylation, and renal medullary ..
  33. Schulte L, Sprenger C, May A. Physiological brainstem mechanisms of trigeminal nociception: An fMRI study at 3T. Neuroimage. 2016;124:518-525 pubmed publisher
    ..network including the periaqueductal gray area, hypothalamus (HT), locus coeruleus and cuneiform nucleus (CNF). Activations of the left CNF were positively correlated with pain intensity ratings...
  34. Pawluczyk I, Najafabadi M, Brown J, Bevington A, Topham P. Sialic acid supplementation ameliorates puromycin aminonucleoside nephrosis in rats. Lab Invest. 2015;95:1019-28 pubmed publisher
    ..Proteinuria and urinary nephrin loss were reduced...
  35. Li T, Lv Y, Su J, Wang Y, Yang Q, Zhang Y, et al. Anchoring CoFe2O4 Nanoparticles on N-Doped Carbon Nanofibers for High-Performance Oxygen Evolution Reaction. Adv Sci (Weinh). 2017;4:1700226 pubmed publisher
    ..nanoparticles with the N-doped carbon nanofibers, the as-synthesized CoFe2O4@N-CNF nanohybrid manifests superior OER performance with a low overpotential, a large current density, a small Tafel ..
  36. Munk M, Brandão H, Nowak S, Mouton L, Gern J, Guimarães A, et al. Direct and indirect toxic effects of cotton-derived cellulose nanofibres on filamentous green algae. Ecotoxicol Environ Saf. 2015;122:399-405 pubmed publisher
    ..Given the increasing rates of CNF production, the potential for their release to the environment and the subsequent impact on ecosystem is becoming ..
  37. Eissa S, Alshehri N, Rahman A, Dasouki M, Abu Salah K, Zourob M. Electrochemical immunosensors for the detection of survival motor neuron (SMN) protein using different carbon nanomaterials-modified electrodes. Biosens Bioelectron. 2018;101:282-289 pubmed publisher
    ..graphene oxide (GO), single wall carbon nanotube (SWCNT), multi-wall carbon nanotube (MWCNT), and carbon nanofiber (CNF)) was performed...
  38. Aprojanz J, Dreyer B, Wehr M, Wiegand J, Baringhaus J, Koch J, et al. Highly anisotropic electric conductivity in PAN-based carbon nanofibers. J Phys Condens Matter. 2017;: pubmed publisher
    ..followed by subsequent annealing steps is a comparably cheap technique to fabricate conductive carbon nanofibers (CNF) made from polyacrylonitrile (PAN) molecules in large quantities...
  39. Hu W, Niu G, Li H, Gao H, Kang R, Chen X, et al. The association between expression of IFIT1 in podocytes of MRL/lpr mice and the renal pathological changes it causes: An animal study. Oncotarget. 2016;7:76464-76470 pubmed publisher
    ..The linear regression analysis found the optical density of IFIT1 was inversely associated with F-actin, Nephrin, and Podocin, but not Synatopodin...
  40. Fukuyo Y, Nakamura T, Bubenshchikova E, Powell R, Tsuji T, Janknecht R, et al. Nephrin and Podocin functions are highly conserved between the zebrafish pronephros and mammalian metanephros. Mol Med Rep. 2014;9:457-65 pubmed publisher
    ..Zebrafish Nephrin and Podocin are important in the formation of the podocyte SD and mutations in NEPHRIN and PODOCIN genes cause ..
  41. Ghanadpour M, Wicklein B, Carosio F, Wågberg L. All-natural and highly flame-resistant freeze-cast foams based on phosphorylated cellulose nanofibrils. Nanoscale. 2018;10:4085-4095 pubmed publisher
    ..nanostructured foams are produced by combining cellulose nanofibrils prepared from phosphorylated pulp fibers (P-CNF) with microfibrous sepiolite clay using the freeze-casting technique...
  42. Haywood E, Ho M, Wilson B. Modular domain swapping among the bacterial cytotoxic necrotizing factor (CNF) family for efficient cargo delivery into mammalian cells. J Biol Chem. 2018;293:3860-3870 pubmed publisher
    ..The cytotoxic necrotizing factor (CNF) family is unique among these toxins in that their homologous sequences are found in a wide array of bacteria, and ..
  43. Xiong J, Wang Y, Shao N, Gao P, Tang H, Su H, et al. The Expression and Significance of NLRP3 Inflammasome in Patients with Primary Glomerular Diseases. Kidney Blood Press Res. 2015;40:344-54 pubmed publisher
    ..Moreover, the increased level of NLRP3 mRNA was correlative with a decrease in nephrin mRNA level and an increase in desmin mRNA level, which indicates that NLRP3 participates in podocyte injury in ..
  44. New L, Keyvani Chahi A, Jones N. Direct regulation of nephrin tyrosine phosphorylation by Nck adaptor proteins. J Biol Chem. 2013;288:1500-10 pubmed publisher
    The transmembrane protein nephrin is a key component of the kidney slit diaphragm that contributes to the morphology of podocyte foot processes through signaling to the underlying actin cytoskeleton...
  45. Dahm M, Schubauer Berigan M, Evans D, Birch M, Fernback J, Deddens J. Carbon Nanotube and Nanofiber Exposure Assessments: An Analysis of 14 Site Visits. Ann Occup Hyg. 2015;59:705-23 pubmed publisher
    ..for wide-ranging health effects that could result from exposure to carbon nanotubes (CNT) and carbon nanofibers (CNF)...
  46. Velásquez Cock J, Gómez H B, Posada P, Serpa G A, Gómez H C, Castro C, et al. Poly (vinyl alcohol) as a capping agent in oven dried cellulose nanofibrils. Carbohydr Polym. 2018;179:118-125 pubmed publisher
    ..Different CNF to PVA ratios were used, and redispersed samples were analyzed in terms of their morphological, physicochemical and ..
  47. Pérez Ràfols C, Serrano N, Díaz Cruz J, Arino C, Esteban M. New approaches to antimony film screen-printed electrodes using carbon-based nanomaterials substrates. Anal Chim Acta. 2016;916:17-23 pubmed publisher
    ..that the in-situ antimony film electrode prepared from carbon nanofibers modified screen-printed electrode (SbSPCE-CNF) produces a better analytical performance as compared to the classical SPCE modified with antimony for Pb(II) and ..
  48. Huang S, Waldron J, Bratman S, Su J, Kim J, Bayley A, et al. Re-evaluation of Ipsilateral Radiation for T1-T2N0-N2b Tonsil Carcinoma at the Princess Margaret Hospital in the Human Papillomavirus Era, 25 Years Later. Int J Radiat Oncol Biol Phys. 2017;98:159-169 pubmed publisher
    ..14; LT: 15% vs 22%, P=.36). Of the 96 patients receiving ipsilateral RT, contralateral neck failure (CNF) occurred in 1/52 HPV+ patients and 1/34 HPV- patients...
  49. Motojima M, Kume T, Matsusaka T. Foxc1 and Foxc2 are necessary to maintain glomerular podocytes. Exp Cell Res. 2017;352:265-272 pubmed publisher
    ..mice, mice ubiquitously expressing inducible-Cre (ROSA26-CreERT2) or mice expressing Cre in podocytes (Nephrin-Cre) were mated with floxed-Foxc1 and floxed-Foxc2 mice...
  50. Nitta S, Komatsu A, Ishii T, Ohnishi M, Inoue A, Iwamoto H. Fabrication and characterization of water-dispersed chitosan nanofiber/poly(ethylene glycol) diacrylate/calcium phosphate-based porous composites. Carbohydr Polym. 2017;174:1034-1040 pubmed publisher
    We evaluated the capacity of chitosan nanofiber (CNF)- and poly(ethylene glycol) (PEG)-based hydrogel/calcium phosphate hybrid (CNF-PEG/CaP) composites to act as scaffolding materials...
  51. Huan S, Yokota S, Bai L, Ago M, Borghei M, Kondo T, et al. Formulation and Composition Effects in Phase Transitions of Emulsions Costabilized by Cellulose Nanofibrils and an Ionic Surfactant. Biomacromolecules. 2017;: pubmed publisher
    Cellulose nanofibrils (CNF) offer great prospects as a natural stabilizer of colloidal dispersions and complex fluids for application in food, pharma, and cosmetics...
  52. Takano K, Kawasaki Y, Imaizumi T, Matsuura H, Nozawa R, Tannji M, et al. Development of glomerular endothelial cells, podocytes and mesangial cells in the human fetus and infant. Tohoku J Exp Med. 2007;212:81-90 pubmed
    ..and FB21, markers for endothelial cells, alpha-smooth muscle actin (alpha-SMA), a marker for mesangial cells, and nephrin, a marker for podocytes...
  53. Khakalo A, Filpponen I, Rojas O. Protein Adsorption Tailors the Surface Energies and Compatibility between Polylactide and Cellulose Nanofibrils. Biomacromolecules. 2017;18:1426-1433 pubmed publisher
    ..is investigated and their role as eco-friendly dispersants and compatibilizers of cellulose nanofibrils (CNF) is elucidated...
  54. Gonzalez R, Tirado A, Balanda M, Alvo M, Barquín I, Durruty P, et al. A pilot study on genetic variation in purine-rich elements in the nephrin gene promoter in type 2 diabetic patients. Biol Res. 2007;40:357-64 pubmed publisher
    ..b>Nephrin, a protein mainly expressed in glomeruli, is decreased in DN and other kidney diseases...
  55. Kafy A, Kim H, Zhai L, Kim J, Hai L, Kang T, et al. Cellulose long fibers fabricated from cellulose nanofibers and its strong and tough characteristics. Sci Rep. 2017;7:17683 pubmed publisher
    Cellulose nanofiber (CNF) with high crystallinity has great mechanical stiffness and strength. However, its length is too short to be used for fibers of environmentally friendly structural composites...
  56. Nechyporchuk O, Bordes R, Köhnke T. Wet Spinning of Flame-Retardant Cellulosic Fibers Supported by Interfacial Complexation of Cellulose Nanofibrils with Silica Nanoparticles. ACS Appl Mater Interfaces. 2017;9:39069-39077 pubmed publisher
    ..for the first time the production of flame-retardant macroscopic fibers from wood-derived cellulose nanofibrils (CNF) and silica nanoparticles (SNP)...
  57. Rinschen M, Hoppe A, Grahammer F, Kann M, Völker L, Schurek E, et al. N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton. J Am Soc Nephrol. 2017;28:2867-2878 pubmed publisher
    ..proteolytic cleavage results in various proteoforms of important podocyte proteins, including those of podocin, nephrin, neph1, ?-actinin-4, and vimentin...
  58. Frishberg Y, Ben Neriah Z, Suvanto M, Rinat C, Männikkö M, Feinstein S, et al. Misleading findings of homozygosity mapping resulting from three novel mutations in NPHS1 encoding nephrin in a highly inbred community. Genet Med. 2007;9:180-4 pubmed
    ..Finnish type (CNF, NPHS1) is a rare autosomal recessive disease caused by mutations in the NPHS1 gene encoding nephrin. We diagnosed congenital nephrotic syndrome in 12 children living in a village near Jerusalem...
  59. Gigante M, Monno F, Roberto R, Laforgia N, Assael M, Livolti S, et al. Congenital nephrotic syndrome of the Finnish type in Italy: a molecular approach. J Nephrol. 2002;15:696-702 pubmed
    ..nephrotic syndrome of the Finnish type (CNF) is an autosomal recessive disorder mainly caused by mutations in the nephrin gene (NPHS1)...
  60. Gong W, Yu J, Wang Q, Li S, Song J, Jia Z, et al. Estrogen-related receptor (ERR) ? protects against puromycin aminonucleoside-induced podocyte apoptosis by targeting PI3K/Akt signaling. Int J Biochem Cell Biol. 2016;78:75-86 pubmed publisher
    ..cell apoptosis accompanied with increased injury markers of B7-1 and cathepsin L and decreased podocyte protein nephrin. In contrast, overexpression of ERR? remarkably attenuated PAN-induced cell apoptosis...
  61. Oor J, Roks D, Broeders J, Hazebroek E, Gooszen H. Seventeen-year Outcome of a Randomized Clinical Trial Comparing Laparoscopic and Conventional Nissen Fundoplication: A Plea for Patient Counseling and Clarification. Ann Surg. 2017;266:23-28 pubmed publisher
    ..clinical trial comparing laparoscopic Nissen fundoplication (LNF) and conventional Nissen fundoplication (CNF) for the treatment of gastroesophageal reflux disease (GERD)...
  62. Feng Y, Mannion A, Madden C, Swennes A, Townes C, Byrd C, et al. Cytotoxic Escherichia coli strains encoding colibactin and cytotoxic necrotizing factor (CNF) colonize laboratory macaques. Gut Pathog. 2017;9:71 pubmed publisher
    ..Colibactin, encoded by a genomic island (pks island), and cytotoxic necrotizing factor (CNF), encoded by the cnf gene, are genotoxic and can modulate cellular differentiation, apoptosis and ..
  63. Wang W, Zhang X, Li C, Du G, Zhang H, Ni Y. Using carboxylated cellulose nanofibers to enhance mechanical and barrier properties of collagen fiber film by electrostatic interaction. J Sci Food Agric. 2017;: pubmed publisher
    ..In this study, the reinforcement of carboxylated cellulose nanofibers (CNF) for collagen film, based on inter-/intra- molecular electrostatic interaction between cationic acid-swollen ..
  64. Yoon K, Shin K, Park J, Cho S, Kim C, Jung J, et al. Brush-Like Cobalt Nitride Anchored Carbon Nanofiber Membrane: Current Collector-Catalyst Integrated Cathode for Long Cycle Li-O2 Batteries. ACS Nano. 2017;: pubmed publisher
    ..Here, we report a rational design of air cathode using a cobalt nitride (Co4N) functionalized carbon nanofiber (CNF) membrane as flexible current collector-catalyst integrated air cathode...
  65. Ciampi O, Iacone R, Longaretti L, Benedetti V, Graf M, Magnone M, et al. Generation of functional podocytes from human induced pluripotent stem cells. Stem Cell Res. 2016;17:130-9 pubmed publisher
    ..cells expressed the main podocyte markers, such as synaptopodin, WT1, ?-Actinin-4, P-cadherin and nephrin at the protein and mRNA level, and showed the low proliferation rate typical of mature podocytes...
  66. Maia T, Larocca N, Beatrice C, de Menezes A, de Freitas Siqueira G, Pessan L, et al. Polyethylene cellulose nanofibrils nanocomposites. Carbohydr Polym. 2017;173:50-56 pubmed publisher
    ..a relatively high content of acrylic acid as a compatibilizer and as an alternative medium to obtain polyethylene CNF nanocomposites...
  67. Wadie W, El Tanbouly D. Vinpocetine mitigates proteinuria and podocytes injury in a rat model of diabetic nephropathy. Eur J Pharmacol. 2017;814:187-195 pubmed publisher
    ..Renal nephrin and podocin contents were increased and their mRNA expressions were replenished in vinpocetine-treated rats...
  68. Paramo E, Palmero S, Heras A, Colina A. Carbon nanostructured films modified by metal nanoparticles supported on filtering membranes for electroanalysis. Talanta. 2018;178:736-742 pubmed publisher
    ..As a proof of concept, a novel bismuth nanoparticle/carbon nanofiber (Bi-NPs/CNF) electrode and a carbon nanotube (CNT)/gold nanoparticle (Au-NPs) have been developed...
  69. Tarrés Q, Pellicer N, Balea A, Merayo N, Negro C, Blanco A, et al. Lignocellulosic micro/nanofibers from wood sawdust applied to recycled fibers for the production of paper bags. Int J Biol Macromol. 2017;105:664-670 pubmed publisher
    ..showed that it was possible to obtain LCMNF with the same reinforcing potential than those cellulose nanofibers (CNF) prepared by oxidative or other chemical methods In fact, the obtained papers increased the breaking length of ..
  70. Zhang Y, Rojas O. Immunosensors for C-Reactive Protein Based on Ultrathin Films of Carboxylated Cellulose Nanofibrils. Biomacromolecules. 2017;18:526-534 pubmed publisher
    ..We report herein the synthesis of immunosensors based on carboxylated cellulose nanofibrils (CNF) for CRP detection, as demonstrated by quartz crystal microgravimetry (QCM)...
  71. Santhosh C, Nivetha R, Kollu P, Srivastava V, Sillanpaa M, Grace A, et al. Removal of cationic and anionic heavy metals from water by 1D and 2D-carbon structures decorated with magnetic nanoparticles. Sci Rep. 2017;7:14107 pubmed publisher
    ..study, cobalt ferrites (C) decorated onto 2D material (porous graphene (PG)) and 1D material (carbon nanofibers (CNF)), denoted as PG-C and CNF-C nanocomposites, respectively, were synthesized using solvothermal process...
  72. Kajiho Y, Harita Y, Kurihara H, Horita S, Matsunaga A, Tsurumi H, et al. SIRP? interacts with nephrin at the podocyte slit diaphragm. FEBS J. 2012;279:3010-21 pubmed publisher
    ..The SD components, nephrin and Neph1, assemble a signaling complex in a tyrosine phosphorylation dependent manner, and regulate the unique ..
  73. Niazi M, Jahan Z, Berg S, Gregersen Ø. Mechanical, thermal and swelling properties of phosphorylated nanocellulose fibrils/PVA nanocomposite membranes. Carbohydr Polym. 2017;177:258-268 pubmed publisher
    Cellulose nanofibrils (CNF) have strong reinforcing properties when incorporated in a compatible polymer matrix...
  74. Yun J, Kim J, Kim D, Lee H. Suppressing polysulfide dissolution via cohesive forces by interwoven carbon nanofibers for high-areal-capacity lithium-sulfur batteries. Nano Lett. 2017;: pubmed publisher
    ..Thus, we demonstrate an electrospun carbon nanofiber (CNF) matrix for a sulfur cathode. This simple design enables a high mass loading of 10...
  75. Heeringa S, Vlangos C, Chernin G, Hinkes B, Gbadegesin R, Liu J, et al. Thirteen novel NPHS1 mutations in a large cohort of children with congenital nephrotic syndrome. Nephrol Dial Transplant. 2008;23:3527-33 pubmed publisher
    ..CNF) features a rather specific renal histology and is caused by recessive mutations in the NPHS1 gene encoding nephrin, a major structural protein of the glomerular slit-diaphragm...
  76. Kojima Y, Isa A, Kobori H, Suzuki S, Ito H, Makise R, et al. Evaluation of Binding Effects in Wood Flour Board Containing Ligno-Cellulose Nanofibers. Materials (Basel). 2014;7:6853-6864 pubmed publisher
    ..Previous studies have shown that the three-dimensional binding effects of cellulose nanofiber (CNF), when mixed with wood flour, can significantly improve the physical and mechanical properties of wood flour board...
  77. Babayeva S, Rocque B, Aoudjit L, Zilber Y, Li J, Baldwin C, et al. Planar cell polarity pathway regulates nephrin endocytosis in developing podocytes. J Biol Chem. 2013;288:24035-48 pubmed publisher
    ..podocytes, activation of the PCP pathway significantly stimulates endocytosis of the core slit diaphragm protein, nephrin, via a clathrin/?-arrestin-dependent endocytic route...