Gene Symbol: necdin
Description: necdin, MAGE family member
Alias: HsT16328, PWCR, necdin, Prader-Willi syndrome chromosome region, necdin homolog, necdin, melanoma antigen (MAGE) family member, necdin-like protein
Species: human
Products:     necdin

Top Publications

  1. Taniura H, Taniguchi N, Hara M, Yoshikawa K. Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1. J Biol Chem. 1998;273:720-8 pubmed
    b>Necdin is a nuclear protein expressed in virtually all postmitotic neurons, and ectopic expression of this protein strongly suppresses the proliferation of NIH3T3 cells...
  2. Bronfman F, Tcherpakov M, Jovin T, Fainzilber M. Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome. J Neurosci. 2003;23:3209-20 pubmed
    ..Finally, NGF induced endosomal association of p75 and its MAGE interactors, necdin and NRAGE...
  3. Kuwako K, Taniura H, Yoshikawa K. Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor. J Biol Chem. 2004;279:1703-12 pubmed
    b>Necdin is a growth suppressor expressed predominantly in postmitotic neurons and implicated in their terminal differentiation. Necdin shows a moderate homology to the MAGE family proteins, the functional roles of which are largely unknown...
  4. Chapman E, Knowles M. Necdin: a multi functional protein with potential tumor suppressor role?. Mol Carcinog. 2009;48:975-81 pubmed publisher
    b>Necdin (NDN), a member of the melanoma-associated antigen (MAGE) family of proteins was first identified in mouse stem cells of embryonal carcinoma origin induced to differentiate by treatment with retinoic acid...
  5. Bush J, Wevrick R. Loss of Necdin impairs myosin activation and delays cell polarization. Genesis. 2010;48:540-53 pubmed publisher
    ..We demonstrate that loss of Necdin in murine and human fibroblasts impairs polarity initiation through a Cdc42-myosin-dependent pathway, thereby ..
  6. Doyle J, Gao J, Wang J, Yang M, Potts P. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. Mol Cell. 2010;39:963-74 pubmed publisher
    ..For example, MAGE-C2-TRIM28 is shown to target p53 for degradation in a proteasome-dependent manner, consistent with its tumorigenic functions. These findings define a biochemical and cellular function for the MAGE protein family. ..
  7. MacDonald H, Wevrick R. The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse. Hum Mol Genet. 1997;6:1873-8 pubmed
    ..We report that the human necdin-encoding gene (NDN) is within the centromeric portion of the PWS deletion region, between the two imprinted genes ..
  8. Jay P, Rougeulle C, Massacrier A, Moncla A, Mattei M, Malzac P, et al. The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region. Nat Genet. 1997;17:357-61 pubmed
    ..It encodes a putative protein homologous to the mouse brain-specific NECDIN protein, NDN; as in mouse, expression in brain is restricted to post-mitotic neurons...
  9. Taniura H, Matsumoto K, Yoshikawa K. Physical and functional interactions of neuronal growth suppressor necdin with p53. J Biol Chem. 1999;274:16242-8 pubmed
    b>Necdin is expressed in virtually all postmitotic neurons, and ectopic expression of this protein suppresses cell proliferation...

More Information

Publications102 found, 100 shown here

  1. Taniguchi N, Taniura H, Niinobe M, Takayama C, Tominaga Yoshino K, Ogura A, et al. The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm. J Biol Chem. 2000;275:31674-81 pubmed
    b>Necdin, a growth suppressor expressed predominantly in postmitotic neurons, interacts with viral oncoproteins and cellular transcription factors E2F1 and p53...
  2. Taniura H, Yoshikawa K. Necdin interacts with the ribonucleoprotein hnRNP U in the nuclear matrix. J Cell Biochem. 2002;84:545-55 pubmed
    b>Necdin is expressed predominantly in terminally differentiated neurons, and its ectopic expression suppresses cell proliferation...
  3. Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K. A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1. J Biol Chem. 2002;277:22541-6 pubmed
    ..RING finger proteins, Praja1 and Neurodap-1, were isolated by yeast two-hybrid screening using the C-terminal necdin homology domain of Dlxin-1 as bait...
  4. Kobayashi M, Taniura H, Yoshikawa K. Ectopic expression of necdin induces differentiation of mouse neuroblastoma cells. J Biol Chem. 2002;277:42128-35 pubmed
    b>Necdin is expressed predominantly in postmitotic neurons, and ectopic expression of this protein strongly suppresses cell growth...
  5. Tcherpakov M, Bronfman F, Conticello S, Vaskovsky A, Levy Z, Niinobe M, et al. The p75 neurotrophin receptor interacts with multiple MAGE proteins. J Biol Chem. 2002;277:49101-4 pubmed
    ..Here we identify two MAGE proteins, necdin and MAGE-H1, as interactors for the intracellular domain of p75 and show that the interaction is enhanced by ..
  6. Lau J, Hanel M, Wevrick R. Tissue-specific and imprinted epigenetic modifications of the human NDN gene. Nucleic Acids Res. 2004;32:3376-82 pubmed
    ..These results suggest that DNA methylation and histone H3 lysine 4 methylation are persistent markers of imprinted gene regulation while histone acetylation participates in tissue-specific activity and silencing in somatic cells. ..
  7. Moon H, Ahn M, Park J, Min K, Kwon Y, Kim K. Negative regulation of hypoxia inducible factor-1alpha by necdin. FEBS Lett. 2005;579:3797-801 pubmed
    ..screening system, we found that the oxygen dependent degradation (ODD) domain of HIF-1alpha interacts with necdin, a growth suppressor...
  8. Hasegawa K, Yoshikawa K. Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons. J Neurosci. 2008;28:8772-84 pubmed publisher
    ..b>Necdin, a p53-interacting protein expressed predominantly in postmitotic neurons, is a melanoma antigen family protein ..
  9. Haviland R, Eschrich S, Bloom G, Ma Y, Minton S, Jove R, et al. Necdin, a negative growth regulator, is a novel STAT3 target gene down-regulated in human cancer. PLoS ONE. 2011;6:e24923 pubmed publisher
    ..Among these genes we identified Necdin, a negative growth regulator, as a novel STAT3 target gene, whose expression is down-regulated at the mRNA and ..
  10. Huang B, Liu A, Zhang C, Xiong N, Zeng Z, Cai Z. Caching Joint Shortcut Routing to Improve Quality of Service for Information-Centric Networking. Sensors (Basel). 2018;18: pubmed publisher
    ..6% and cut down the length of routing path for users to obtain their interested data by 28.6?85.7% compared with the traditional NDN scheme. Moreover, the length of uploading routing path could be decreased by 8.3?33.3%. ..
  11. Yamazaki W, Takahashi M, Kawahara M. Restricted development of mouse triploid fetuses with disorganized expression of imprinted genes. Zygote. 2015;23:874-84 pubmed publisher
    ..These data suggest that both DNA ploidy and asymmetrical functions of parental genomes separately influence mammalian ontogeny. ..
  12. Gaspar R, Santana I, Mendes C, Fernandes A, Duro D, Simões M, et al. Genetic Variation of MT-ND Genes in Frontotemporal Lobar Degeneration: Biochemical Phenotype-Genotype Correlation. Neurodegener Dis. 2015;15:70-80 pubmed publisher
    ..Although the majority of these alterations are not primarily pathogenic, an interaction with other mutations may occur, leading to the disease, worsening its expression or influencing age of onset. ..
  13. Zhang H, Guan M, Townsend K, Huang T, An D, Yan X, et al. MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1α signaling network. EMBO Rep. 2015;16:1378-93 pubmed publisher
    ..Concomitantly, miR-455 also targets the adipogenic suppressors Runx1t1 and Necdin, initiating adipogenic differentiation...
  14. Liu B, Li Y, Stackpole E, Novak A, Gao Y, Zhao Y, et al. Regulatory discrimination of mRNAs by FMRP controls mouse adult neural stem cell differentiation. Proc Natl Acad Sci U S A. 2018;115:E11397-E11405 pubmed publisher
    ..Knockdown of NECDIN, an FMRP-repressed transcriptional factor, rescued neuronal differentiation...
  15. Akinwande O. Interest Forwarding in Named Data Networking Using Reinforcement Learning. Sensors (Basel). 2018;18: pubmed publisher
  16. Nakagaki A, Osanai H, Kishino T. Imprinting analysis of the mouse chromosome 7C region in DNMT1-null embryos. Gene. 2014;553:63-8 pubmed publisher
  17. Barka E, Kerrache C, Hussain R, Lagraa N, Lakas A, Bouk S. A Trusted Lightweight Communication Strategy for Flying Named Data Networking. Sensors (Basel). 2018;18: pubmed publisher
  18. Nakagaki A, Hirano S, Urakawa A, Mitake M, Kishino T. Transgenic mice with a tandem duplication of the Necdin gene overexpress Necdin. Mamm Genome. 2018;29:680-689 pubmed publisher
    b>Necdin (Ndn) transgenic (Tg) mice were generated with a bacterial artificial chromosome (BAC) clone...
  19. Lynes M, Schulz T, Pan A, Tseng Y. Disruption of insulin signaling in Myf5-expressing progenitors leads to marked paucity of brown fat but normal muscle development. Endocrinology. 2015;156:1637-47 pubmed publisher
    ..Expression of adipogenic inhibitors preadipocyte factor-1, Necdin, and wingless-type MMTV integration site member 10a in the residual BAT tissue was nonetheless increased compared ..
  20. Lee J, Ghil S. Regulator of G protein signaling 8 inhibits protease-activated receptor 1/Gi/o signaling by forming a distinct G protein-dependent complex in live cells. Cell Signal. 2016;28:391-400 pubmed publisher
    ..adenylyl cyclase and ERK activation, and prevented Gαo-induced neurite outgrowth and activation of Necdin protein, a downstream target of Gαo...
  21. Figdore B, Stensel H, Winkler M. Comparison of different aerobic granular sludge types for activated sludge nitrification bioaugmentation potential. Bioresour Technol. 2018;251:189-196 pubmed publisher
    ..Nitrosomonas was the dominant ammonia-oxidizing bacteria, while Candidatus Nitrotoga was an abundant nitrite-oxidizer in all granule types. ..
  22. Khor E, Fanshawe B, Qi Y, Zolotukhin S, Kulkarni R, Enriquez R, et al. Prader-Willi Critical Region, a Non-Translated, Imprinted Central Regulator of Bone Mass: Possible Role in Skeletal Abnormalities in Prader-Willi Syndrome. PLoS ONE. 2016;11:e0148155 pubmed publisher
    ..A number of causative loci have been located within the imprinted Prader-Willi Critical Region (PWCR), including a set of small non-translated nucleolar RNA's (snoRNA)...
  23. Virani S, Light E, Peterson L, Sartor M, Taylor J, McHugh J, et al. Stability of methylation markers in head and neck squamous cell carcinoma. Head Neck. 2016;38 Suppl 1:E1325-31 pubmed publisher
    ..There were no significant differences in overall methylation of CCNA1 (cyclin A1), NDN (necdin), deleted in colorectal carcinoma (DCC), and cluster of differentiation 1a (CD1A) within paired specimens (p ..
  24. Feng S, Ye G, Bai S, Wei H, Liao X, Li L. Matrix Metalloproteinase-9 -1562C/T Gene Polymorphism Is Associated with Diabetic Nephropathy. Biomed Res Int. 2016;2016:1627143 pubmed publisher
    ..The MMP9 -1562C allele, SBP, Cr, BUN, TG, and TC were independent risk factors for DN. All of the above suggested that the MMP9 -1562C/T polymorphism was associated with DN in Han Chinese. ..
  25. Yuan Y, Wang H, Wei Z, Li W. Impaired autophagy in hilar mossy cells of the dentate gyrus and its implication in schizophrenia. J Genet Genomics. 2015;42:1-8 pubmed publisher the hilar mossy cells of the sdy mice by using the TUNEL assay and immunostaining of cleaved caspase-3 or necdin, a dysbindin-1- and p53-interacting protein required for neuronal survival...
  26. Kappil M, Green B, Armstrong D, Sharp A, Lambertini L, Marsit C, et al. Placental expression profile of imprinted genes impacts birth weight. Epigenetics. 2015;10:842-9 pubmed publisher
  27. Kim H, Kim M, Kim S, Joen D, Lee K. Protective Effects of Nintedanib against Polyhexamethylene Guanidine Phosphate-Induced Lung Fibrosis in Mice. Molecules. 2018;23: pubmed publisher
    ..These results suggest that NDN may mitigate the inflammatory response and development of pulmonary fibrosis in the lungs of mice treated with PHMG. ..
  28. Martina M, Noel S, Saxena A, Rabb H, Hamad A. Double negative (DN) ?? T cells: misperception and overdue recognition. Immunol Cell Biol. 2015;93:305-10 pubmed publisher
    ..By doing so, we hope to provoke a new discussion that may lead to a consensus about the origin of lpr DN T cells and regulation of their homeostasis by the Fas pathway and reignite wider interest in nDN T cells. ..
  29. Dabhi B, Mistry K. Oxidative stress and its association with TNF-α-308 G/C and IL-1α-889 C/T gene polymorphisms in patients with diabetes and diabetic nephropathy. Gene. 2015;562:197-202 pubmed publisher
    ..The higher serum levels of oxidative stress markers in diabetic patients with nephropathy suggest the possible role of oxidative stress. ..
  30. Chang M, Huang C, Liu H, Chen Y, Hsieh C. Stress-Induced and Diabetic Hyperglycemia Associated with Higher Mortality among Intensive Care Unit Trauma Patients: Cross-Sectional Analysis of the Propensity Score-Matched Population. Int J Environ Res Public Health. 2018;15: pubmed publisher
    ..These results suggest that hyperglycemia is detrimental in patients with or without DM who were admitted to the ICU, and there is a different pathophysiological mechanisms behind the SIH and DH. ..
  31. Liu S, Wu N, Liu J, Ming X, Chen J, Pavelec D, et al. Novel NTRK1 Frameshift Mutation in Congenital Insensitivity to Pain With Anhidrosis. J Child Neurol. 2015;30:1357-61 pubmed publisher
    ..In addition, necdin (encoded by NDN) is also essential in nerve growth factor-tropomyosin-related kinase A pathway...
  32. Hannan A, Arshad S, Azam M, Loo J, Ahmed S, Majeed M, et al. Disaster Management System Aided by Named Data Network of Things: Architecture, Design, and Analysis. Sensors (Basel). 2018;18: pubmed publisher
    ..From results, it is found that NDN-DISCA exhibits minimal delay and improved throughput when compared to the legacy NDN and existing PUSH schemes. ..
  33. Shao X, Zhang R, Hu C, Wang C, Lu J, Qin W, et al. Precise microdeletion detection of Prader-Willi Syndrome with array comparative genome hybridization. Biomed Environ Sci. 2010;23:194-8 pubmed publisher
    ..A novel feature of metacarpophalangeal joint rigidity was also presented, which is the first time reported in PWS. ..
  34. Lanfray D, Caron A, Roy M, Laplante M, Morin F, Leprince J, et al. Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice. elife. 2016;5: pubmed publisher
    ..Taken together, these data suggest that ACBD7-producing neurons are involved in the hypothalamic control exerted on food intake and energy expenditure by the leptin-melanocortin pathway. ..
  35. De Donato M, Peters S, Hussain T, Rodulfo H, Thomas B, Babar M, et al. Molecular evolution of type II MAGE genes from ancestral MAGED2 gene and their phylogenetic resolution of basal mammalian clades. Mamm Genome. 2017;28:443-454 pubmed publisher
  36. Fung E, Tsukamoto H. Morphogen-related therapeutic targets for liver fibrosis. Clin Res Hepatol Gastroenterol. 2015;39 Suppl 1:S69-74 pubmed publisher
    ..However, in liver disease, myofibroblastic HSCs express morphogens such as Wnt, Shh, Necdin, DLK1, and Notch as part of their participation in fibrogenesis and wound healing...
  37. Lee H, Choi N, Lee S, Ko K, Hwang T, Han D, et al. Epigenetic alteration of imprinted genes during neural differentiation of germline-derived pluripotent stem cells. Epigenetics. 2016;11:177-83 pubmed publisher
  38. Shi Q, Li C, Li K, Liu Q. Pallidin protein in neurodevelopment and its relation to the pathogenesis of schizophrenia. Mol Med Rep. 2017;15:665-672 pubmed publisher
    ..Moreover, since pallidin can also affect neuronal differentiation and its variants seem to be related to an increased risk of schizophrenia, it is possible that both pallidin and p38 play a role in the pathogenesis of the disease. ..
  39. Rossi L, Nicoletti M, Carmosino M, Mastrofrancesco L, Di Franco A, Indrio F, et al. Urinary Excretion of Kidney Aquaporins as Possible Diagnostic Biomarker of Diabetic Nephropathy. J Diabetes Res. 2017;2017:4360357 pubmed publisher
    ..The same analysis, focusing on uAQP2, showed comparable results. Taken together, these data suggest a possible use of AQP5 and AQP2 as novel noninvasive biomarkers to help in classifying the clinical stage of DN. ..
  40. Chatterjee R, Gupta S, Law S. Hematopathological alterations of major tumor suppressor cascade, vital cell cycle inhibitors and hematopoietic niche components in experimental myelodysplasia. Chem Biol Interact. 2017;273:1-10 pubmed publisher
  41. Guo J, Fu X, Andrés Baquero G, Sobhani R, Nolasco D, Rosso D. Trade-off between carbon emission and effluent quality of activated sludge processes under seasonal variations of wastewater temperature and mean cell retention time. Sci Total Environ. 2016;547:331-344 pubmed publisher
  42. Bermejo S, Soler M, Gimeno J, Barrios C, Rodríguez E, Mojal S, et al. Predictive factors for non-diabetic nephropathy in diabetic patients. The utility of renal biopsy. Nefrologia. 2016;36:535-544 pubmed publisher
    ..Higher creatinine levels, shorter duration of diabetes, absence of diabetic retinopathy, lower proteinuria, and older age were risk factors for NDN. Patients with DN and nephrotic-range proteinuria had worse renal prognosis. ..
  43. Crespi B, Read S, Salminen I, Hurd P. A genetic locus for paranoia. Biol Lett. 2018;14: pubmed publisher
    ..These findings provide a single-locus genetic model for analysing the neurological and psychological bases of paranoid thinking, and implicate imprinted genes, and genomic conflicts, in human mentalistic thought. ..
  44. Vega Díaz N, González Cabrera F, Marrero Robayna S, Santana Estupiñan R, Gallego Samper R, Henríquez Palop F, et al. Renal Replacement Therapy: Purifying Efficiency of Automated Peritoneal Dialysis in Diabetic versus Non-Diabetic Patients. J Clin Med. 2015;4:1518-35 pubmed publisher
    ..The cause of chronic kidney disease (CKD) does not seem to influence the cleansing effectiveness of the technique. ..
  45. Yassai M, Demos W, Janczak T, Naumova E, Gorski J. CDR3 clonotype and amino acid motif diversity of BV19 expressing circulating human CD8 T cells. Hum Immunol. 2016;77:137-145 pubmed publisher
    ..The motif repertoire distribution was also diverse, complex and self-similar with respect to CDR3 length, NDN start and length. ..
  46. Fujimoto I, Hasegawa K, Fujiwara K, Yamada M, Yoshikawa K. Necdin controls EGFR signaling linked to astrocyte differentiation in primary cortical progenitor cells. Cell Signal. 2016;28:94-107 pubmed publisher
    ..However, regulatory mechanisms of EGFR signaling in CPCs remain largely unknown. Here we demonstrate that necdin, a MAGE (melanoma antigen) family protein, interacts with EGFR in primary CPCs and represses its downstream ..
  47. Zhu H, Yu W, Xie Y, Zhang H, Bi Y, Zhu D. Association of Pentraxin 3 Gene Polymorphisms with Susceptibility to Diabetic Nephropathy. Med Sci Monit. 2017;23:428-436 pubmed
    ..0319). CONCLUSIONS Our findings suggested that PTX3 polymorphisms were associated with an increased risk for DN in Chinese patients with type 2 diabetes. ..
  48. Dabhi B, Mistry K, Patel H, Lal S. Vascular endothelial growth factor insertion/deletion gene polymorphism in West Indian patients of type 2 diabetes and diabetic nephropathy. Indian J Biochem Biophys. 2015;52:209-12 pubmed
    ..Our study suggests that I/D polymorphism in the promoter region of the VEGF gene is not associated with DN in type 2 diabetes patients, but might have a role in development of non-diabetic nephropathy. ..
  49. Rau C, Wu S, Chen Y, Chien P, Hsieh H, Kuo P, et al. Mortality Rate Associated with Admission Hyperglycemia in Traumatic Femoral Fracture Patients Is Greater Than Non-Diabetic Normoglycemic Patients but Not Diabetic Normoglycemic Patients. Int J Environ Res Public Health. 2017;15: pubmed publisher
  50. Chang I, Wang Y, Wu W, Liang P, Li W, Yeh B, et al. Necdin Overexpression Predicts Poor Prognosis in Patients with Urothelial Carcinomas of the Upper Urinary Tract and Urinary Bladder. J Cancer. 2016;7:304-13 pubmed publisher
    ..Immunohistochemical study was performed to determine NDN protein (a.k.a. Necdin) expression evaluated by H-score method in 340 UTUCs and 295 UBUCs...
  51. Yassai M, Demos W, Gorski J. CDR3 motif generation and selection in the BV19-utilizing subset of the human CD8 T cell repertoire. Mol Immunol. 2016;72:57-64 pubmed publisher
    ..As these data were collected from an older healthy individual they can be used to model successful repertoire selection and to further define characteristics associated with a positive history of responses to pathogen exposures. ..
  52. Agustriawan D, Huang C, Sheu J, Lee S, Tsai J, Kurubanjerdjit N, et al. DNA methylation-regulated microRNA pathways in ovarian serous cystadenocarcinoma: A meta-analysis. Comput Biol Chem. 2016;65:154-164 pubmed publisher
    ..The inclusion of direct DNA methylated miRNA events may offer another layer of explanation that along with genetics can give a better understanding of the carcinogenesis process. ..
  53. Yassai M, Demos W, Gorski J. Structural and Mechanistic Implications of Rearrangement Frequencies within Human TCRBV Genes. J Immunol. 2017;199:1142-1152 pubmed publisher
    ..The data are discussed in terms of the generation of a structural turn motif, the rearrangement mechanism, and selection of the repertoire on the peptide and MHC. ..
  54. Liang F, Diao L, Jiang N, Zhang J, Wang H, Zhou W, et al. Chronic exposure to ethanol in male mice may be associated with hearing loss in offspring. Asian J Androl. 2015;17:985-90 pubmed publisher
    ..Our results provide possible epigenetic evidence for a paternal ethanol exposure contribution to Fetal Alcohol Syndrome (FAS). ..
  55. Yamazaki W, Amano T, Bai H, Takahashi M, Kawahara M. The Influence of Polyploidy and Genome Composition on Genomic Imprinting in Mice. J Biol Chem. 2016;291:20924-20931 pubmed
    ..This study provides the first detailed analysis of genomic imprinting in tetraploid fetuses, suggesting that imprinted gene expression is disrupted, but DNA methylation statuses of DMRs are stable following changes in ploidy in mammals. ..
  56. Adnani L, Langevin L, Gautier E, Dixit R, Parsons K, Li S, et al. Zac1 Regulates the Differentiation and Migration of Neocortical Neurons via Pac1. J Neurosci. 2015;35:13430-47 pubmed publisher
    ..g., Dlk1, Peg3, Ube3a, necdin, and Grb10)...
  57. Burnett L, LeDuc C, Sulsona C, Paull D, Eddiry S, Levy B, et al. Induced pluripotent stem cells (iPSC) created from skin fibroblasts of patients with Prader-Willi syndrome (PWS) retain the molecular signature of PWS. Stem Cell Res. 2016;17:526-530 pubmed publisher
    ..Genes within the PWS minimum critical deletion region remain silenced in both PWS large deletion and microdeletion iPSC following reprogramming. PWS iPSC and their relevant differentiated cell types could provide in vitro models of PWS. ..
  58. Oeffner F, Korn T, Roth H, Ziegler A, Hinney A, Goldschmidt H, et al. Systematic screening for mutations in the human necdin gene (NDN): identification of two naturally occurring polymorphisms and association analysis in body weight regulation. Int J Obes Relat Metab Disord. 2001;25:767-9 pubmed
    NDN, which codes for the human necdin protein, is a candidate gene for Prader-Willi syndrome (PWS). One feature of this neurogenetic disorder is hyperphagia resulting in extreme obesity observed later in development...
  59. Lee M, Beggs S, Gildea D, Bupp S, Lichtenberg J, Trivedi N, et al. Necdin is a breast cancer metastasis suppressor that regulates the transcription of c-Myc. Oncotarget. 2015;6:31557-68 pubmed publisher
    ..Earlier studies using a mammary tumorigenesis mouse model identified Necdin (Ndn)as a germline modifier of metastasis...
  60. Litzky J, Deyssenroth M, Everson T, Armstrong D, Lambertini L, Chen J, et al. Placental imprinting variation associated with assisted reproductive technologies and subfertility. Epigenetics. 2017;12:653-661 pubmed publisher
    ..Our findings indicate that epigenetic differences in placentas resulting from IVF pregnancies may be related to the underlying subfertility in parents using IVF rather than the IVF procedure itself. ..
  61. Matarazzo V, Caccialupi L, Schaller F, Shvarev Y, Kourdougli N, Bertoni A, et al. Necdin shapes serotonergic development and SERT activity modulating breathing in a mouse model for Prader-Willi syndrome. elife. 2017;6: pubmed publisher
    ..The Necdin-deficient mouse is the only model that reproduces the respiratory phenotype of PWS (central apnea and blunted ..
  62. Aizawa T, Maruyama K, Kondo H, Yoshikawa K. Expression of necdin, an embryonal carcinoma-derived nuclear protein, in developing mouse brain. Brain Res Dev Brain Res. 1992;68:265-74 pubmed
    b>Necdin is a polypeptide sequence encoded by neural differentiation-specific mRNA derived from embryonal carcinoma cells...
  63. Zanella S, Watrin F, Mebarek S, Marly F, Roussel M, Gire C, et al. Necdin plays a role in the serotonergic modulation of the mouse respiratory network: implication for Prader-Willi syndrome. J Neurosci. 2008;28:1745-55 pubmed publisher a neurogenetic disease resulting from the absence of paternal expression of several imprinted genes, including NECDIN. Prader-Willi children and adults have severe breathing defects with irregular rhythm, frequent sleep apneas, and ..
  64. Yoshikawa K. [Regulation of neuronal development by the imprinted gene Necdin]. No To Hattatsu. 2009;41:214-8 pubmed
  65. Beneduzzi D, Iyer A, Trarbach E, Silveira Neto A, Silveira L, Tusset C, et al. Mutational analysis of the necdin gene in patients with congenital isolated hypogonadotropic hypogonadism. Eur J Endocrinol. 2011;165:145-50 pubmed publisher
    b>Necdin activates GNRH gene expression and is fundamental for the development, migration, and axonal extension of murine GNRH neurons...
  66. Lafontaine J, Tchakarska G, Rodier F, Mes Masson A. Necdin modulates proliferative cell survival of human cells in response to radiation-induced genotoxic stress. BMC Cancer. 2012;12:234 pubmed publisher
    ..A better understanding of the genes that contribute to the establishment of senescence is therefore warranted. Necdin interacts with p53 and is also a p53 target gene, although the importance of Necdin in the p53 response is not ..
  67. Francois S, D Orlando C, Fatone T, Touvier T, Pessina P, Meneveri R, et al. Necdin enhances myoblasts survival by facilitating the degradation of the mediator of apoptosis CCAR1/CARP1. PLoS ONE. 2012;7:e43335 pubmed publisher
    ..Survival of the satellite cells is a critical requirement for efficient muscle reconstitution. Necdin, a member of the MAGE proteins family, is expressed in satellite cell-derived myogenic precursors during perinatal ..
  68. Huang Z, Fujiwara K, Minamide R, Hasegawa K, Yoshikawa K. Necdin controls proliferation and apoptosis of embryonic neural stem cells in an oxygen tension-dependent manner. J Neurosci. 2013;33:10362-73 pubmed publisher
    ..b>Necdin, a MAGE (melanoma antigen) family protein, is expressed abundantly in postmitotic neurons and possesses potent ..
  69. Virani S, Bellile E, Bradford C, Carey T, Chepeha D, Colacino J, et al. NDN and CD1A are novel prognostic methylation markers in patients with head and neck squamous carcinomas. BMC Cancer. 2015;15:825 pubmed publisher
    ..Here, we identified novel methylation markers and specific, epigenetic molecular differences associated with HPV status, which warrant further investigation. ..
  70. Yang H, Das P, Yu Y, Mao W, Wang Y, Baggerly K, et al. NDN is an imprinted tumor suppressor gene that is downregulated in ovarian cancers through genetic and epigenetic mechanisms. Oncotarget. 2016;7:3018-32 pubmed publisher
  71. Hasegawa K, Yasuda T, Shiraishi C, Fujiwara K, Przedborski S, Mochizuki H, et al. Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults. Nat Commun. 2016;7:10943 pubmed publisher
    ..PGC-1α is a master regulator of mitochondrial biogenesis and function. Here we identify necdin as a potent PGC-1α stabilizer that promotes mitochondrial biogenesis via PGC-1α in mammalian neurons...
  72. Berger S, Ciccone C, Simon K, Malicdan M, Vilboux T, Billington C, et al. Exome analysis of Smith-Magenis-like syndrome cohort identifies de novo likely pathogenic variants. Hum Genet. 2017;136:409-420 pubmed publisher
    ..One candidate variant was located in an alpha helix of Necdin (NDN), phased to the paternally inherited allele. NDN is maternally imprinted within the 15q11...
  73. Ju H, Lee S, Lee J, Ghil S. Necdin modulates osteogenic cell differentiation by regulating Dlx5 and MAGE-D1. Biochem Biophys Res Commun. 2017;489:109-115 pubmed publisher
    ..Neurally differentiated embryonal carcinoma-derived protein (Necdin) has been identified as a key regulator of cell differentiation in various tissues, including neuronal, adipose, ..
  74. Wijesuriya T, De Ceuninck L, Masschaele D, Sanderson M, Carias K, Tavernier J, et al. The Prader-Willi syndrome proteins MAGEL2 and necdin regulate leptin receptor cell surface abundance through ubiquitination pathways. Hum Mol Genet. 2017;26:4215-4230 pubmed publisher
    ..Two PWS candidate genes encode MAGEL2 and necdin, related melanoma antigen proteins that assemble into ubiquitination complexes...
  75. Rau C, Wu S, Chen Y, Chien P, Hsieh H, Kuo P, et al. Stress-Induced Hyperglycemia, but Not Diabetic Hyperglycemia, Is Associated with Higher Mortality in Patients with Isolated Moderate and Severe Traumatic Brain Injury: Analysis of a Propensity Score-Matched Population. Int J Environ Res Public Health. 2017;14: pubmed publisher
    ..However, the adjusted mortality was significantly higher only in the selected propensity score-matched patients with SIH and not in those with DH. ..
  76. Nakada Y, Taniura H, Uetsuki T, Inazawa J, Yoshikawa K. The human chromosomal gene for necdin, a neuronal growth suppressor, in the Prader-Willi syndrome deletion region. Gene. 1998;213:65-72 pubmed
    b>Necdin is a growth suppressor expressed in virtually all postmitotic neurons in the brain. The human necdin gene, NDN, is maternally imprinted and deleted in the Prader-Willi syndrome, a neurobehavioral contiguous gene disorder...
  77. Hu B, Wang S, Zhang Y, Feghali C, Dingman J, Wright T. A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression. Proc Natl Acad Sci U S A. 2003;100:10008-13 pubmed
    ..By using a yeast two-hybrid method, we found that pre-IL-1 alpha binds necdin, a nuclear protein with growth suppressor activity...
  78. Liu X, Wang Y, Zhang Y, Zhu W, Xu X, Niinobe M, et al. Nogo-A inhibits necdin-accelerated neurite outgrowth by retaining necdin in the cytoplasm. Mol Cell Neurosci. 2009;41:51-61 pubmed publisher
    ..We identified a new interaction between Nogo-66 and necdin. Mutagenesis analysis revealed that the central region of necdin was indispensable for the interaction of necdin ..
  79. Ingraham C, Wertalik L, Schor N. Necdin and neurotrophin receptors: interactors of relevance for neuronal resistance to oxidant stress. Pediatr Res. 2011;69:279-84 pubmed publisher
    b>Necdin is a protein known to interact with the neurotrophin receptors, neurotrophic tyrosine kinase receptor type 1 (TrkA) and 75 kD low-affinity neurotrophin receptor (p75NTR)...
  80. Ma X, Fei E, Fu C, Ren H, Wang G. Dysbindin-1, a schizophrenia-related protein, facilitates neurite outgrowth by promoting the transcriptional activity of p53. Mol Psychiatry. 2011;16:1105-16 pubmed publisher
    ..In this study, we identified necdin as a binding partner of dysbindin-1 using a yeast two-hybrid screen...
  81. Bush J, Wevrick R. Loss of the Prader-Willi obesity syndrome protein necdin promotes adipogenesis. Gene. 2012;497:45-51 pubmed publisher
    We investigated the role of necdin during adipogenic differentiation. Necdin is one of several genes inactivated in children with Prader-Willi syndrome, who are predisposed to increased adiposity at the expense of lean mass...
  82. Park Y, Kang J, Lee D, Kim M, Bak Y, Yang Y, et al. Interleukin-32α modulates promyelocytic leukemia zinc finger gene activity by inhibiting protein kinase Cɛ-dependent sumoylation. Int J Biochem Cell Biol. 2014;55:136-43 pubmed publisher
    ..Together, our data suggest that IL-32α associates with PLZF and PKCɛ, and then inhibits PLZF sumoylation, resulting in suppression of the transcriptional activity of PLZF. ..
  83. Hu Y, Chen Q, Lü Y, Zhang J, Lin C, Zhang F, et al. Hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer. Oncotarget. 2017;8:46191-46203 pubmed publisher
    ..These findings might provide a new theoretical basis for the pathogenesis of CRC and facilitate the development of new therapeutic strategies against CRC. ..
  84. Gibson C, de Ruijter Villani M, Stout T. Negative uterine asynchrony retards early equine conceptus development and upregulation of placental imprinted genes. Placenta. 2017;57:175-182 pubmed publisher
    ..We propose that this ability to 'reset' conceptus development to uterine stage is an adaptation that explains why horse embryos are unusually tolerant of asynchrony after ET. ..
  85. Rau C, Wu S, Chen Y, Chien P, Hsieh H, Kuo P, et al. Higher Mortality in Trauma Patients Is Associated with Stress-Induced Hyperglycemia, but Not Diabetic Hyperglycemia: A Cross-Sectional Analysis Based on a Propensity-Score Matching Approach. Int J Environ Res Public Health. 2017;14: pubmed publisher
  86. Sułkowski W, Owczarek K, Olszewski J. Contemporary noise-induced hearing loss (NIHL) prevention. Otolaryngol Pol. 2017;71:1-7 pubmed publisher
  87. Yao C, Kobayashi M, Chen S, NABINGER S, Gao R, Liu S, et al. Necdin modulates leukemia-initiating cell quiescence and chemotherapy response. Oncotarget. 2017;8:87607-87622 pubmed publisher
    ..While we demonstrated that p53 target gene Necdin maintains hematopoietic stem cell (HSC) quiescence, its roles in LIC quiescence and response to chemotherapy are ..
  88. Niinobe M, Koyama K, Yoshikawa K. Cellular and subcellular localization of necdin in fetal and adult mouse brain. Dev Neurosci. 2000;22:310-9 pubmed
    b>Necdin is a 325-amino-acid residue protein encoded by a cDNA clone isolated from neurally differentiated embryonal carcinoma cells. Ectopic expression of necdin induces growth arrest of proliferative cells...
  89. Aebischer J, Sturny R, Andrieu D, Rieusset A, Schaller F, Geib S, et al. Necdin protects embryonic motoneurons from programmed cell death. PLoS ONE. 2011;6:e23764 pubmed publisher
    b>NECDIN belongs to the type II Melanoma Associated Antigen Gene Expression gene family and is located in the Prader-Willi Syndrome (PWS) critical region. Necdin-deficient mice develop symptoms of PWS, including a sensory and motor deficit...
  90. De Faveri L, Hurst C, Platt F, Taylor C, Roulson J, Sanchez Carbayo M, et al. Putative tumour suppressor gene necdin is hypermethylated and mutated in human cancer. Br J Cancer. 2013;108:1368-77 pubmed publisher
    b>Necdin (NDN) expression is downregulated in telomerase-immortalised normal human urothelial cells. Telomerase-immortalised normal human urothelial cells have no detected genetic alterations...