Gene Symbol: NECAB3
Description: N-terminal EF-hand calcium binding protein 3
Alias: APBA2BP, EFCBP3, NIP1, STIP3, SYTIP2, XB51, dJ63M2.4, dJ63M2.5, N-terminal EF-hand calcium-binding protein 3, EF-hand calcium binding protein 3, Nek2-interacting protein 1, X11L-binding protein 51, amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein, amyloid beta A4 protein-binding family A member 2-binding protein, neuronal calcium-binding protein 3, neuronal calcium-binding protein NECAB3, synaptotagmin interacting protein 2, synaptotagmin interacting protein STIP3
Species: human
Products:     NECAB3

Top Publications

  1. Kennedy K, Ostrakhovitch E, Sandiford S, Dayarathna T, Xie X, Waese E, et al. Mammalian numb-interacting protein 1/dual oxidase maturation factor 1 directs neuronal fate in stem cells. J Biol Chem. 2010;285:17974-85 pubmed publisher
    In this study, we describe a role for the mammalian Numb-interacting protein 1 (Nip1) in regulation of neuronal differentiation in stem cells...
  2. Mateluna P, Salvatierra A, Solís S, Nunez G, Pimentel P. Involvement of aquaporin NIP1;1 in the contrasting tolerance response to root hypoxia in Prunus rootstocks. J Plant Physiol. 2018;228:19-28 pubmed publisher
    ..Concomitantly, we detected an increase in the mRNA abundance of Prunus spp. NIP1;1, a putative lactic acid transporter...
  3. Lenoble V, Meouche W, Laatikainen K, Garnier C, Brisset H, Margaillan A, et al. Assessment and modelling of Ni(II) retention by an ion-imprinted polymer: application in natural samples. J Colloid Interface Sci. 2015;448:473-81 pubmed publisher
    ..Non-Imprinted Polymers (NIP1, NIP2 and NIP3) were prepared as control polymers in similar conditions but with pure VbIDA instead of VbIDA-Ni...
  4. Xu W, Dai W, Yan H, Li S, Shen H, Chen Y, et al. Arabidopsis NIP3;1 Plays an Important Role in Arsenic Uptake and Root-to-Shoot Translocation under Arsenite Stress Conditions. Mol Plant. 2015;8:722-33 pubmed publisher
    ..nodulin 26-like intrinsic protein (NIP) subfamily of aquaporin proteins consists of nine members, five of which (NIP1;1, NIP1;2, NIP5;1, NIP6;1, and NIP7;1) were previously identified to be permeable to arsenite...
  5. Kouba T, Rutkai E, Karásková M, Valášek L. The eIF3c/NIP1 PCI domain interacts with RNA and RACK1/ASC1 and promotes assembly of translation preinitiation complexes. Nucleic Acids Res. 2012;40:2683-99 pubmed publisher
    ..multisubunit 26S proteasome lid, CSN and eIF3 complexes, which constitutes most of the C-terminal region of the c/NIP1 subunit...
  6. Looseley M, Griffe L, Büttner B, Wright K, Middlefell Williams J, Bull H, et al. Resistance to Rhynchosporium commune in a collection of European spring barley germplasm. Theor Appl Genet. 2018;131:2513-2528 pubmed publisher
    ..Seedling assays with R. commune single-spore isolates expressing the corresponding avirulence protein NIP1 confirmed that this locus is Rrs1...
  7. Karásková M, Gunišová S, Herrmannová A, Wagner S, Munzarová V, Valášek L. Functional characterization of the role of the N-terminal domain of the c/Nip1 subunit of eukaryotic initiation factor 3 (eIF3) in AUG recognition. J Biol Chem. 2012;287:28420-34 pubmed publisher
    ..Here we subjected several previously identified segments of the N-terminal domain (NTD) of the eIF3c/Nip1 subunit, which mediates eIF3 binding to eIF1 and eIF5, to semirandom mutagenesis to investigate the molecular ..
  8. Oda M, Azuma T. Affinity maturation of anti-(4-hydroxy-3-nitrophenyl)acetyl antibodies accompanies a modulation of antigen specificity. Mol Immunol. 2016;70:8-12 pubmed publisher
    ..maturation accompanies in the fine specificity of these antibodies by analyzing the interaction between NP1-, NIP1-, or NNP1-hen egg lysozyme and anti-NP antibodies that possess different association constants to NP using a ..
  9. Linde C, Smith L, Peakall R. Weeds, as ancillary hosts, pose disproportionate risk for virulent pathogen transfer to crops. BMC Evol Biol. 2016;16:101 pubmed publisher
    ..effective population size) and cultivated barley (low genetic diversity) using microsatellites, effector locus nip1 diversity and pathogen aggressiveness in order to assess the importance of weeds in the evolution of the neutral ..

More Information


  1. Wang Y, Li R, Li D, Jia X, Zhou D, Li J, et al. NIP1;2 is a plasma membrane-localized transporter mediating aluminum uptake, translocation, and tolerance in Arabidopsis. Proc Natl Acad Sci U S A. 2017;114:5047-5052 pubmed publisher
    ..Here we report that NIP1;2, a plasma membrane-localized member of the Arabidopsis nodulin 26-like intrinsic protein (NIP) subfamily ..
  2. Sadhukhan A, Kobayashi Y, Nakano Y, Iuchi S, Kobayashi M, Sahoo L, et al. Genome-wide Association Study Reveals that the Aquaporin NIP1;1 Contributes to Variation in Hydrogen Peroxide Sensitivity in Arabidopsis thaliana. Mol Plant. 2017;10:1082-1094 pubmed publisher
    ..were associated with a cluster of chromosome 4 genes encoding an aquaporin NODULIN 26-LIKE INTRINSIC PROTEIN 1; 1 (NIP1;1), an NB-ARC domain-containing disease resistance protein (AT4G19050), and a putative membrane lipoprotein (..
  3. Kim H, Kim E, Yoo K, Lee M, Choi J, Park H, et al. Isolation and expression analysis of Alzheimer's disease-related gene xb51 in zebrafish. Dev Dyn. 2008;237:3921-6 pubmed publisher
    b>XB51 protein is known to interact with the amino-terminal of the X11L protein and to be involved in Abeta40 generation, a hallmark of Alzheimer's disease...
  4. Yoo J, Chang J, Kim S, Jang S, Wolgemuth D, Kim K, et al. NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi. Exp Cell Res. 2004;292:393-402 pubmed
    ..yeast two-hybrid screening and isolated Nek2-Interacting Protein 1 (NIP1), which has been also named as XB51 and NECAB3. Physical interactions of Nek2 with NIP1 were confirmed. In fact, Nek2 can phosphorylate NIP1 in vivo...
  5. Sumioka A, Imoto S, Martins R, Kirino Y, Suzuki T. XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms. Biochem J. 2003;374:261-8 pubmed
    b>XB51 (derived from X11-like binding protein of clone number 51) was isolated by yeast two-hybrid cDNA screening using the N-terminal domain of X11L (X11-like protein) as a bait...
  6. Sugita S, Ho A, Sudhof T. NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. Neuroscience. 2002;112:51-63 pubmed
    ..We suggest that NECABs represent a novel family of regulatory Ca(2+)-binding proteins with an unusual domain structure and a limited expression in a subclass of neurons. ..
  7. Lee D, Tomita S, Kirino Y, Suzuki T. Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein. J Biol Chem. 2000;275:23134-8 pubmed
    We isolated a cDNA encoding a novel protein, XB51, that interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L)...
  8. Nakaoka H, Hara T, Yoshino S, Kanamori A, Matsui Y, Shimamura T, et al. NECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer Cells. Sci Rep. 2016;6:22784 pubmed publisher
    ..Yeast two-hybrid screening using Mint3 as bait identified N-terminal EF-hand calcium binding protein 3 (NECAB3) as a novel factor regulating HIF-1 activity via Mint3...
  9. Sugita S, Sudhof T. Specificity of Ca2+-dependent protein interactions mediated by the C2A domains of synaptotagmins. Biochemistry. 2000;39:2940-9 pubmed
  10. Büssow K, Cahill D, Nietfeld W, Bancroft D, Scherzinger E, Lehrach H, et al. A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. Nucleic Acids Res. 1998;26:5007-8 pubmed
    ..His antibody, Qiagen) detected 20% of the library as putative expression clones. Two example genes, GAPDH and HSP90alpha, were identified on high-density filters using DNA probes and antibodies against their proteins. ..
  11. Anderson L, Aquino F, Raeber A, Chen X, Wong B. Halogen Bonding Interactions: Revised Benchmarks and a New Assessment of Exchange vs. Dispersion. J Chem Theory Comput. 2017;: pubmed publisher
    ..for calculating halogen-bonding interactions in a wide variety of complex dimers (69 total) within the XB18 and XB51 benchmark sets...