NDRG1

Summary

Gene Symbol: NDRG1
Description: N-myc downstream regulated 1
Alias: CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5, protein NDRG1, N-myc downstream-regulated gene 1 protein, differentiation-related gene 1 protein, nickel-specific induction protein Cap43, protein regulated by oxygen-1, reducing agents and tunicamycin-responsive protein
Species: human
Products:     NDRG1

Top Publications

  1. Maruyama Y, Ono M, Kawahara A, Yokoyama T, Basaki Y, Kage M, et al. Tumor growth suppression in pancreatic cancer by a putative metastasis suppressor gene Cap43/NDRG1/Drg-1 through modulation of angiogenesis. Cancer Res. 2006;66:6233-42 pubmed
    ..as a nickel- and calcium-induced gene, and is also known as N-myc downstream-regulated gene 1 (NDRG1), Drg-1 and rit42. It is also reported that overexpression of Cap43 suppresses metastasis of some malignancies, but its precise role ..
  2. Song Y, Oda Y, Hori M, Kuroiwa K, Ono M, Hosoi F, et al. N-myc downstream regulated gene-1/Cap43 may play an important role in malignant progression of prostate cancer, in its close association with E-cadherin. Hum Pathol. 2010;41:214-22 pubmed publisher
    N-myc downstream regulated gene-1 (NDRG1)/Cap43 plays an important role in tumor progression and metastases in many kinds of cancers...
  3. Angst E, Dawson D, Stroka D, Gloor B, Park J, Candinas D, et al. N-myc downstream regulated gene-1 expression correlates with reduced pancreatic cancer growth and increased apoptosis in vitro and in vivo. Surgery. 2011;149:614-24 pubmed publisher
    The role of N-myc downstream regulated gene-1 (NDRG1) in cancer has recently gained interest, as potential regulator of cell death and tumor suppressor...
  4. Li S, Chen J, Yang Z, Lu G, Tang H, Hu H. N-myc downstream-regulated gene 1 as a downregulated target gene of PTEN in the controlling of tumourigenesis in endometrioid carcinoma. Indian J Med Res. 2008;127:453-9 pubmed
    ..b>NDRG1 (N-myc downstream-regulated gene 1) is reported to be associated with tumourigenesis...
  5. Akiba J, Ogasawara S, Kawahara A, Nishida N, Sanada S, Moriya F, et al. N-myc downstream regulated gene 1 (NDRG1)/Cap43 enhances portal vein invasion and intrahepatic metastasis in human hepatocellular carcinoma. Oncol Rep. 2008;20:1329-35 pubmed
    N-myc downstream regulated gene 1 (NDRG1)/Cap43 is a 43 kDa protein that is widely distributed in the body...
  6. Piquemal D, Joulia D, Balaguer P, Basset A, Marti J, Commes T. Differential expression of the RTP/Drg1/Ndr1 gene product in proliferating and growth arrested cells. Biochim Biophys Acta. 1999;1450:364-73 pubmed
    ..the cDNA of a gene identical to Drg1 and homologous to other recently discovered genes, respectively human RTP and Cap43 and mouse Ndr1 and TDD5 genes...
  7. Masuda K, Ono M, Okamoto M, Morikawa W, Otsubo M, Migita T, et al. Downregulation of Cap43 gene by von Hippel-Lindau tumor suppressor protein in human renal cancer cells. Int J Cancer. 2003;105:803-10 pubmed
    We previously identified 9 genes (i.e., thymosin beta4, secreted protein acidic and rich in cysteine, Cap43, ceruloplasmin, serum amyloid A, heat shock protein 90, LOT1, osteopontin and casein kinase Igamma) that are more highly ..
  8. Murakami Y, Hosoi F, Izumi H, Maruyama Y, Ureshino H, Watari K, et al. Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells. Biochem Biophys Res Commun. 2010;396:376-81 pubmed publisher
    ..reported that N-myc downstream-regulated gene 1 (NDRG1)/Ca(2+)-associated protein with a molecular mass of 43kDa (Cap43) suppresses angiogenesis and tumor growth of pancreatic cancer through marked decreases in both the expression of ..
  9. Sohda M, Mochida Y, Kato H, Miyazaki T, Nakajima M, Fukuchi M, et al. Overexpression of Cap43 is associated with malignant status of esophageal cancer. Anticancer Res. 2009;29:965-70 pubmed
    b>Cap43 protein has been proven to be upregulated by nickel compounds or hypoxic stress, often during cell differentiation or cell growth arrest. However, the function of this gene remains unknown...

More Information

Publications64

  1. Kovacevic Z, Richardson D. The metastasis suppressor, Ndrg-1: a new ally in the fight against cancer. Carcinogenesis. 2006;27:2355-66 pubmed
    ..by androgens and is involved in the pathology of the disease, Hereditary Motor and Sensory Neuropathy-Lom (HMSNL)...
  2. Zhang S, Song S, Li B, Zhou Y, Zhang Y. Expression of N-myc downstream-regulated gene 1 in primary gallbladder carcinoma and its correlation with clinicopathological features and clinical outcome. Med Oncol. 2012;29:1866-72 pubmed publisher
    N-myc downstream-regulated gene 1 (NDRG1), a member of the N-myc downstream-regulated gene family, is induced under a wide variety of stress and cell growth-regulatory conditions...
  3. Inagaki Y, Tang W, Xu H, Guo Q, Mafune K, Konishi T, et al. Localization of N-myc downstream-regulated gene 1 in gastric cancer tissue. Dig Liver Dis. 2009;41:96-103 pubmed publisher
    ..Localization of N-myc downstream-regulated gene 1 and its significant correlation with p53 expression may play an important role in cancer progression. ..
  4. van Belzen N, Dinjens W, Diesveld M, Groen N, van der Made A, Nozawa Y, et al. A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms. Lab Invest. 1997;77:85-92 pubmed
    ..Using a modified differential display procedure, we cloned a novel cDNA, designated differentiation-related gene 1 (Drg1)...
  5. Zhang P, Tchou Wong K, Costa M. Egr-1 mediates hypoxia-inducible transcription of the NDRG1 gene through an overlapping Egr-1/Sp1 binding site in the promoter. Cancer Res. 2007;67:9125-33 pubmed
    N-myc down-regulated gene 1 (NDRG1/Cap43) is inducible by a variety of environmental stressors, including hypoxia. The present study identified a cis-acting element mediating the transactivation of the NDRG1 gene in murine RAW264...
  6. Kokame K, Kato H, Miyata T. Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes. J Biol Chem. 1996;271:29659-65 pubmed
    ..encoded a novel protein with 394 amino acids, which was termed reducing agents and tunicamycin-responsive protein (RTP)...
  7. Shah M, Kemeny N, Hummer A, Drobnjak M, Motwani M, Cordon Cardo C, et al. Drg1 expression in 131 colorectal liver metastases: correlation with clinical variables and patient outcomes. Clin Cancer Res. 2005;11:3296-302 pubmed
    The differentiation-related gene-1 (Drg1) is a recently identified gene down-regulated in malignancy and a putative suppressor of colorectal cancer metastases...
  8. Kovacevic Z, Fu D, Richardson D. The iron-regulated metastasis suppressor, Ndrg-1: identification of novel molecular targets. Biochim Biophys Acta. 2008;1783:1981-92 pubmed publisher
    ..These findings provide a potential link between the observed functions of Ndrg-1 and its molecular targets, further demonstrating its anti-metastatic effect. ..
  9. Sibold S, Roh V, Keogh A, Studer P, Tiffon C, Angst E, et al. Hypoxia increases cytoplasmic expression of NDRG1, but is insufficient for its membrane localization in human hepatocellular carcinoma. FEBS Lett. 2007;581:989-94 pubmed
    b>NDRG1 is a hypoxia-inducible protein, whose modulated expression is associated with the progression of human cancers...
  10. Li Q, Chen H. Transcriptional silencing of N-Myc downstream-regulated gene 1 (NDRG1) in metastatic colon cancer cell line SW620. Clin Exp Metastasis. 2011;28:127-35 pubmed publisher
    N-Myc downstream-regulated gene 1 (NDRG1) plays vital roles in tumor metastasis suppression and is frequently silenced in metastatic colon cancers. NDRG1 is silenced in a highly metastatic colon cancer cell line SW620...
  11. Wang Z, Wang F, Wang W, Gao Q, Wei W, Yang Y, et al. Correlation of N-myc downstream-regulated gene 1 overexpression with progressive growth of colorectal neoplasm. World J Gastroenterol. 2004;10:550-4 pubmed
    To study the function of N-myc downstream-regulated gene 1 (NDRG1) in colorectal carcinogenesis and its correlation with tumor lymph node metastasis...
  12. Pflueger D, Rickman D, Sboner A, Perner S, Lafargue C, Svensson M, et al. N-myc downstream regulated gene 1 (NDRG1) is fused to ERG in prostate cancer. Neoplasia. 2009;11:804-11 pubmed
    ..prostate cancer case and then discovered a novel fusion involving the androgen-inducible tumor suppressor, NDRG1 (N-myc downstream regulated gene 1), and ERG in two cases...
  13. Li J, Kretzner L. The growth-inhibitory Ndrg1 gene is a Myc negative target in human neuroblastomas and other cell types with overexpressed N- or c-myc. Mol Cell Biochem. 2003;250:91-105 pubmed
    ..Using differential display, we find the previously described growth-inhibitory gene Ndrg1 is strongly repressed in all tested Nb cell lines bearing N-myc amplification, as well as in a neuroepithelioma ..
  14. Chen B, Nelson D, Sadovsky Y. N-myc down-regulated gene 1 modulates the response of term human trophoblasts to hypoxic injury. J Biol Chem. 2006;281:2764-72 pubmed
    ..The expression of the protein N-myc down-regulated gene 1 (NDRG1) is regulated during cell proliferation, differentiation, and in response to stress...
  15. Murray J, Campbell D, Morrice N, Auld G, Shpiro N, Marquez R, et al. Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3. Biochem J. 2004;384:477-88 pubmed
    ..SGK1 also phosphorylated the related NDRG1 isoform at Thr328, Ser330 and Thr346 (equivalent to Thr330, Ser332 and Thr348 of NDRG2), as well as Thr356 and ..
  16. Karaczyn A, Ivanov S, Reynolds M, Zhitkovich A, Kasprzak K, Salnikow K. Ascorbate depletion mediates up-regulation of hypoxia-associated proteins by cell density and nickel. J Cell Biochem. 2006;97:1025-35 pubmed
    ..cells to carcinogenic nickel compounds in the presence of oxygen up-regulated carbonic anhydrase IX (CA IX) and NDRG1/Cap43, both known as intrinsic hypoxia markers and cancer-associated genes...
  17. Hosoi F, Izumi H, Kawahara A, Murakami Y, Kinoshita H, Kage M, et al. N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expression. Cancer Res. 2009;69:4983-91 pubmed publisher
    N-myc downstream regulated gene 1 (NDRG1)/Cap43 expression is a predictive marker of good prognosis in patients with pancreatic cancer as we reported previously...
  18. Liu W, Iiizumi Gairani M, Okuda H, Kobayashi A, Watabe M, Pai S, et al. KAI1 gene is engaged in NDRG1 gene-mediated metastasis suppression through the ATF3-NFkappaB complex in human prostate cancer. J Biol Chem. 2011;286:18949-59 pubmed publisher
    b>NDRG1 and KAI1 belong to metastasis suppressor genes, which impede the dissemination of tumor cells from primary tumors to distant organs...
  19. Fotovati A, Abu Ali S, Kage M, Shirouzu K, Yamana H, Kuwano M. N-myc downstream-regulated gene 1 (NDRG1) a differentiation marker of human breast cancer. Pathol Oncol Res. 2011;17:525-33 pubmed publisher
    N-myc downstream-regulated gene 1 (NDRG1), also called differentiation-related gene-1 (Drg1) and Cap43, is expressed in various normal tissues and suppressed in several malignancies...
  20. Zhou R, Kokame K, Tsukamoto Y, Yutani C, Kato H, Miyata T. Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. Genomics. 2001;73:86-97 pubmed
    RTP/Drg1/Cap43/rit42/TDD5/Ndr1/NDRG1 (referred to as NDRG1 hereafter) is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation...
  21. Park H, Adams M, Lachat P, Bosman F, Pang S, Graham C. Hypoxia induces the expression of a 43-kDa protein (PROXY-1) in normal and malignant cells. Biochem Biophys Res Commun. 2000;276:321-8 pubmed
    ..cells and later shown to be upregulated in various human and mouse cell types (termed RTP, Drg1, Cap43, rit42, Ndr1). Herein we refer to this gene product as PROXY-1, for Protein Regulated by OXYgen-1...
  22. Sun J, Zhang D, Zheng Y, Zhao Q, Zheng M, Kovacevic Z, et al. Targeting the metastasis suppressor, NDRG1, using novel iron chelators: regulation of stress fiber-mediated tumor cell migration via modulation of the ROCK1/pMLC2 signaling pathway. Mol Pharmacol. 2013;83:454-69 pubmed publisher
    The iron-regulated metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), is up-regulated by cellular iron depletion mediated by iron chelators and can inhibit cancer cell migration...
  23. Kalaydjieva L, Gresham D, Gooding R, Heather L, Baas F, de Jonge R, et al. N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom. Am J Hum Genet. 2000;67:47-58 pubmed
    ..Here we report the identification of the gene responsible for hereditary motor and sensory neuropathy-Lom (HMSNL)...
  24. Hunter M, Angelicheva D, Tournev I, Ingley E, Chan D, Watts G, et al. NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24. Biochem Biophys Res Commun. 2005;332:982-92 pubmed
    Hereditary Motor and Sensory Neuropathy Lom (HMSNL) is a severe autosomal recessive peripheral neuropathy, the most common form of demyelinating Charcot-Marie-Tooth (CMT) disease in the Roma (Gypsy) population...
  25. Zhou D, Salnikow K, Costa M. Cap43, a novel gene specifically induced by Ni2+ compounds. Cancer Res. 1998;58:2182-9 pubmed
    ..One gene, Cap43, which expressed a 3...
  26. Guan R, Ford H, Fu Y, Li Y, Shaw L, Pardee A. Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer. Cancer Res. 2000;60:749-55 pubmed
    ..We propose that Drg-1 suppresses colon cancer metastasis by inducing colon cancer cell differentiation and partially reversing the metastatic phenotype. ..
  27. Ando T, Ishiguro H, Kimura M, Mitsui A, Kurehara H, Sugito N, et al. Decreased expression of NDRG1 is correlated with tumor progression and poor prognosis in patients with esophageal squamous cell carcinoma. Dis Esophagus. 2006;19:454-8 pubmed
    b>NDRG1 (N-myc downstream regulated gene-1) was reported to be necessary for p53-mediated apoptosis and to be regulated by PTEN (phosphatase and tensin homolog). In several cancers, it was suggested to be a tumor suppressor gene...
  28. Azuma K, Kawahara A, Hattori S, Taira T, Tsurutani J, Watari K, et al. NDRG1/Cap43/Drg-1 may predict tumor angiogenesis and poor outcome in patients with lung cancer. J Thorac Oncol. 2012;7:779-89 pubmed publisher
    Expression of N-myc downstream-regulated gene 1 (NDRG1)/Cap43 is a prognostic indicator of human malignancies according to the tumor type in which it occurs...
  29. Kurdistani S, Arizti P, Reimer C, Sugrue M, Aaronson S, Lee S. Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage. Cancer Res. 1998;58:4439-44 pubmed
    ..This clone, designated rit42 (reduced in tumor, 42 kDa), was previously isolated as a homocysteine-inducible gene in human endothelial cells (..
  30. Strzelczyk B, Szulc A, Rzepko R, Kitowska A, Skokowski J, Szutowicz A, et al. Identification of high-risk stage II colorectal tumors by combined analysis of the NDRG1 gene expression and the depth of tumor invasion. Ann Surg Oncol. 2009;16:1287-94 pubmed publisher
    ..on cancer cell lines and animal models indicated that alteration in expression of N-myc down-regulated gene 1 (NDRG1) is associated with development of colon cancer...
  31. Jung E, Yoon J, Lee Y, Lee J, Kim B, Yu S, et al. Hypoxia and retinoic acid-inducible NDRG1 expression is responsible for doxorubicin and retinoic acid resistance in hepatocellular carcinoma cells. Cancer Lett. 2010;298:9-15 pubmed publisher
    ..N-myc downstream-regulated gene-1 (NDRG1) is a hypoxia- and retinoic acid-inducible protein, and has been previously implicated in carcinogenesis...
  32. Angst E, Dawson D, Nguyen A, Park J, Go V, Reber H, et al. Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells. Pancreas. 2010;39:675-9 pubmed publisher
    N-myc downstream-regulated gene 1 (NDRG1), important in tumor growth and metastasis, has recently gained interest as a potential therapeutic target...
  33. Chen Z, Zhang D, Yue F, Zheng M, Kovacevic Z, Richardson D. The iron chelators Dp44mT and DFO inhibit TGF-?-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1). J Biol Chem. 2012;287:17016-28 pubmed publisher
    ..growth factor-? (TGF-?) regulates the EMT and the metastasis suppressor gene, N-myc downstream-regulated gene-1 (NDRG1), could play a role in regulating the TGF-? pathway...
  34. Liu Y, Bai W, Luo W, Zhang D, Yan Y, Xu Z, et al. Downregulation of NDRG1 promotes invasion of human gastric cancer AGS cells through MMP-2. Tumour Biol. 2011;32:99-105 pubmed publisher
    The N-myc downstream-regulated gene-1 (NDRG1) has recently been proposed as a metastasis suppressor, but its precise role remains unclear...
  35. Cheng J, Xie H, Xu X, Wu J, Wei X, Su R, et al. NDRG1 as a biomarker for metastasis, recurrence and of poor prognosis in hepatocellular carcinoma. Cancer Lett. 2011;310:35-45 pubmed publisher
    N-myc downstream-regulated gene 1 (NDRG1) has been reported to be a multifunctional protein associated with carcinogenesis, however, the cellular function of NDRG1 remains elusive in human cancers...
  36. Chang X, Zhang S, Ma J, Li Z, Zhi Y, Chen J, et al. Association of NDRG1 gene promoter methylation with reduced NDRG1 expression in gastric cancer cells and tissue specimens. Cell Biochem Biophys. 2013;66:93-101 pubmed publisher
    b>NDRG1 (N-myc downstream-regulated gene 1) plays a role in cell differentiation and suppression of tumor metastasis...
  37. Toffoli S, Delaive E, Dieu M, Feron O, Raes M, Michiels C. NDRG1 and CRK-I/II are regulators of endothelial cell migration under Intermittent Hypoxia. Angiogenesis. 2009;12:339-54 pubmed publisher
    ..Amongst the proteins of which the abundance varied under IH, NDRG1 and CRK-I/II were identified by mass spectrometry...
  38. Lerner A, Grafi Cohen M, Napso T, Azzam N, Fares F. The indolic diet-derivative, 3,3'-diindolylmethane, induced apoptosis in human colon cancer cells through upregulation of NDRG1. J Biomed Biotechnol. 2012;2012:256178 pubmed publisher
    ..3,3'-diindolylmethane induced apoptosis may represent a new regulator of N-myc downstream regulated gene-1 in poorly differentiated colonic cancer cells. ..
  39. Jiang K, Shen Z, Ye Y, Yang X, Wang S. A novel molecular marker for early detection and evaluating prognosis of gastric cancer: N-myc downstream regulated gene-1 (NDRG1). Scand J Gastroenterol. 2010;45:898-908 pubmed publisher
    N-myc downstream regulated gene-1 (NDRG1) is known as a differentiation-related gene that plays important roles in cell differentiation, organ formation, and embryonic development...
  40. Zhang J, Chen S, Zhang W, Zhang J, Liu X, Shi H, et al. Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region. Gene. 2008;417:5-12 pubmed publisher
    N-Myc downstream-regulated gene 1 (ndrg1) is up-regulated in N-Myc knockout mouse embryos. The human NDRG family consists of 4 highly homologous members and human Ndrg1 exhibits approximately 94% homology with mouse ndrg1...
  41. Cangul H, Salnikow K, Yee H, Zagzag D, Commes T, Costa M. Enhanced expression of a novel protein in human cancer cells: a potential aid to cancer diagnosis. Cell Biol Toxicol. 2002;18:87-96 pubmed
    b>Cap43 is a protein whose RNA is induced under conditions of severe hypoxia or prolonged elevations of intracellular calcium...
  42. Kovacevic Z, Chikhani S, Lui G, Sivagurunathan S, Richardson D. The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathways. Antioxid Redox Signal. 2013;18:874-87 pubmed publisher
    The metastasis suppressor gene, N-myc downstream regulated gene-1 (NDRG1), is negatively correlated with tumor progression in multiple neoplasms, including pancreatic cancer...
  43. Stein S, Thomas E, Herzog B, Westfall M, Rocheleau J, Jackson R, et al. NDRG1 is necessary for p53-dependent apoptosis. J Biol Chem. 2004;279:48930-40 pubmed
    ..In the study reported here, we isolated a p53-regulated gene named NDRG1 (N-Myc down-regulated gene 1). Its expression is induced by DNA damage in a p53-dependent fashion...
  44. Wang Q, Li L, Gao G, Wang G, Qu L, Li J, et al. HIF-1? up-regulates NDRG1 expression through binding to NDRG1 promoter, leading to proliferation of lung cancer A549 cells. Mol Biol Rep. 2013;40:3723-9 pubmed publisher
    ..b>NDRG1 is a member of the N-myc downregulated gene (NDRG) family, and it has strong hypoxia stress reaction functions...
  45. Angst E, Sibold S, Tiffon C, Weimann R, Gloor B, Candinas D, et al. Cellular differentiation determines the expression of the hypoxia-inducible protein NDRG1 in pancreatic cancer. Br J Cancer. 2006;95:307-13 pubmed
    N-myc downstream-regulated gene-1 (NDRG1) is a recently described hypoxia-inducible protein that is upregulated in various human cancers...
  46. Lachat P, Shaw P, Gebhard S, van Belzen N, Chaubert P, Bosman F. Expression of NDRG1, a differentiation-related gene, in human tissues. Histochem Cell Biol. 2002;118:399-408 pubmed
    b>NDRG1 is a member of the new N-myc downregulated gene (NDRG) family which belongs to the alpha/beta hydrolase superfamily, but without presenting a hydrolytic catalytic site...
  47. Lai L, Su Y, Chen K, Tsai M, Sher Y, Lu T, et al. Down-regulation of NDRG1 promotes migration of cancer cells during reoxygenation. PLoS ONE. 2011;6:e24375 pubmed publisher
    ..In particular, human N-MYC down-regulated gene 1 (NDRG1) was highly suppressed upon reoxygenation...
  48. Nagai M, Gerhard R, Fregnani J, Nonogaki S, Rierger R, Netto M, et al. Prognostic value of NDRG1 and SPARC protein expression in breast cancer patients. Breast Cancer Res Treat. 2011;126:1-14 pubmed publisher
    ..shown altered expression of secreted protein acidic and rich in cysteine (SPARC) and N-myc down-regulated gene (NDRG1) in several malignancies, including breast carcinoma; however, the role of these potential biomarkers in tumor ..
  49. Liu R, Li J, Teng Z, Zhang Z, Xu Y. Overexpressed microRNA-182 promotes proliferation and invasion in prostate cancer PC-3 cells by down-regulating N-myc downstream regulated gene 1 (NDRG1). PLoS ONE. 2013;8:e68982 pubmed publisher
    ..Additionally, we demonstrated that miR-182 could downregulate expression of NDRG1 by directly targeting the NDRG1 3'-untranslated region...
  50. Bandyopadhyay S, Pai S, Gross S, Hirota S, Hosobe S, Miura K, et al. The Drg-1 gene suppresses tumor metastasis in prostate cancer. Cancer Res. 2003;63:1731-6 pubmed
    ..These results strongly suggest that Drg-1 is a candidate metastasis suppressor gene for prostate cancer and may serve as a useful prognostic marker. ..
  51. Le N, Richardson D. Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation. Blood. 2004;104:2967-75 pubmed
    ..From the genes assessed, only the N-myc downstream-regulated gene 1 (Ndrg1) was specifically up-regulated by Fe chelation...
  52. Cho Y, Cho E, Lee J, Yu S, Kim Y, Kim C, et al. Fucoidan-induced ID-1 suppression inhibits the in vitro and in vivo invasion of hepatocellular carcinoma cells. Biomed Pharmacother. 2016;83:607-616 pubmed publisher
    ..05) in a NDRG-1/CAP43-dependent manner...
  53. Mai H, Chun D, Schneider A, Erickson B, Freshman R, Kester B, et al. Performance-Based Outcomes After Anterior Cruciate Ligament Reconstruction in Professional Athletes Differ Between Sports. Am J Sports Med. 2017;45:2226-2232 pubmed publisher
    ..Sport-specific performance statistics were collected before and after surgery for each athlete. Return to play (RTP) was defined as a successful return to the active roster for at least 1 regular-season game after ACLR...
  54. Cen G, Zhang K, Cao J, Qiu Z. Downregulation of the N-myc downstream regulated gene 1 is related to enhanced proliferation, invasion and migration of pancreatic cancer. Oncol Rep. 2017;37:1189-1195 pubmed publisher
    The N-myc downstream regulated gene 1 (NDRG1) is differently expressed in human malignancies according to the tumor type...
  55. Pezzotta G, Querques G, Pecorelli A, Nani R, Sironi S. MRI detection of soleus muscle injuries in professional football players. Skeletal Radiol. 2017;46:1513-1520 pubmed publisher
    ..Classification (BAMIC), and to investigate the association between specific MRI features and the "return to play" (RTP)...