NDOR1

Summary

Gene Symbol: NDOR1
Description: NADPH dependent diflavin oxidoreductase 1
Alias: NR1, bA350O14.9, NADPH-dependent diflavin oxidoreductase 1, NADPH-dependent FMN and FAD-containing oxidoreductase
Species: human
Products:     NDOR1

Top Publications

  1. Wang C, Zhang X, Liu F, Paule M, Slikker W. Anesthetic-induced oxidative stress and potential protection. ScientificWorldJournal. 2010;10:1473-82 pubmed publisher
    ..agonists cause neuronal cell death are still not completely understood, up-regulation of the NMDA receptor subunit NR1 may be an initiative factor in neuronal cell death...
  2. Kapolowicz M, Thompson L. Acute high-intensity noise induces rapid Arc protein expression but fails to rapidly change GAD expression in amygdala and hippocampus of rats: Effects of treatment with D-cycloserine. Hear Res. 2016;342:69-79 pubmed publisher
    ..Finally, the ability of D-cycloserine (DCS; an NMDA-receptor NR1 partial agonist) to reduce or prevent the noise trauma-related plastic changes in the biomarker, Arc, was tested...
  3. Liu J, Wu S, Zhang H, Kuang F. Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice. Neurotherapeutics. 2018;15:1093-1111 pubmed publisher
    ..MyD88 inhibition also augmented glutamate transporter 1 expression and reduced N-methyl-D-aspartate receptor NR1 subunit expression in the hippocampus to protect pyramidal neurons from apoptosis...
  4. Carr H, Alexander T, Groves T, Kiffer F, Wang J, PRICE E, et al. Early effects of 16O radiation on neuronal morphology and cognition in a murine model. Life Sci Space Res (Amst). 2018;17:63-73 pubmed publisher
    ..Exposure to 16O significantly reduced the expression of Nr1 and GluR1 in the hippocampus and modulated spine morphology in the dentate gyrus and cornu Ammon 1 within the ..
  5. Ma C, Wang C, Zhang Q, Lian Y. Emerging role of prodromal headache in patients with anti-N-methyl-D-aspartate receptor encephalitis. J Pain Res. 2019;12:519-526 pubmed publisher
    ..The results strongly suggest that the NR1 subunit of NMDAR is involved in prodromal headache...
  6. Wang H, Huang F, Hu Z, Zhang W, Qiao X, Huang Y, et al. Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline. Neurotox Res. 2017;31:505-520 pubmed publisher
    ..ESI also decreased expression of hippocampal NMDA receptor subunits, NR1, and AMPA receptor subunits, GluR1 and GluR2, which are involved in synaptic plasticity, but it did not affect ..
  7. Zhou X, Yang H, Song X, Wang J, Shen L, Wang J. Central blockade of the AT1 receptor attenuates pressor effects via reduction of glutamate release and downregulation of NMDA/AMPA receptors in the rostral ventrolateral medulla of rats with stress-induced hypertension. Hypertens Res. 2019;: pubmed publisher
    ..HR), plasma norepinephrine (NE), glutamate, and the expression of N-methyl-D-aspartic acid (NMDA) receptor subunit NR1, and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors in the RVLM increased in the SIH group...
  8. Mizuki D, Matsumoto K, Tanaka K, Thi Le X, Fujiwara H, Ishikawa T, et al. Antidepressant-like effect of Butea superba in mice exposed to chronic mild stress and its possible mechanism of action. J Ethnopharmacol. 2014;156:16-25 pubmed publisher
    ..AMP-responsive element binding protein (CREB) and a phosphorylated form of N-methyl-d-aspartate receptor subunit NR1, synaptic plasticity-related signaling proteins...
  9. Sung C, Wen Z, Feng C, Chen C, Huang S, Chen N, et al. Potentiation of spinal glutamatergic response in the neuron-glia interactions underlies the intrathecal IL-1?-induced thermal hyperalgesia in rats. CNS Neurosci Ther. 2017;23:580-589 pubmed publisher
    ..IL-1? increased phosphorylation of NR-1 (p-NR1) subunit of N-methyl-D-aspartate receptors in neurons and microglia, reduced glutamate transporters (GTs; glutamate/..

More Information

Publications127 found, 100 shown here

  1. Gafford G, Jasnow A, Ressler K. Grin1 receptor deletion within CRF neurons enhances fear memory. PLoS ONE. 2014;9:e111009 pubmed publisher
    ..0Cre) (Martin et al., 2010). In these studies, mice that have the gene that encodes NR1 (Grin1) flanked by loxP sites (floxed) were crossed with our previously developed CRFp3...
  2. Tachibana M, Shinohara M, Yamazaki Y, Liu C, Rogers J, Bu G, et al. Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1. Exp Neurol. 2016;277:1-9 pubmed publisher
    ..While levels of PSD95, glutamate receptor 1 (GluR1), and N-methyl-d-aspartate receptor NR1 subunit (NR1), which are key postsynaptic proteins that regulate synaptic plasticity, were decreased with aging, ..
  3. Jayakumar A, Tong X, Shamaladevi N, Barcelona S, Gaidosh G, Agarwal A, et al. Defective synthesis and release of astrocytic thrombospondin-1 mediates the neuronal TDP-43 proteinopathy, resulting in defects in neuronal integrity associated with chronic traumatic encephalopathy: in vitro studies. J Neurochem. 2017;140:645-661 pubmed publisher
    ..Defective neuronal integrity, as evidenced by a reduction in levels of the NR1 subunit of the NMDA receptor, and in PSD95, along with increased levels of phosphorylated tau were also observed...
  4. Yao G, Yue H, Yun Y, Sang N. Chronic SO2 inhalation above environmental standard impairs neuronal behavior and represses glutamate receptor gene expression and memory-related kinase activation via neuroinflammation in rats. Environ Res. 2015;137:85-93 pubmed publisher
    ..we detected that SO2 inhalation reduced the expression of Arc and glutamate receptor subunits (GluR1, GluR2, NR1, NR2A, and NR2B) with a concentration-dependent property in comparison to controls...
  5. Sajjad J, Felice V, Golubeva A, Cryan J, O Mahony S. Sex-dependent activity of the spinal excitatory amino acid transporter: Role of estrous cycle. Neuroscience. 2016;333:311-9 pubmed publisher
    ..The gene expression of EAATs, glutamate receptor subunits NR1 and NR2B and the estrogen receptors ERα & ERβ in the spinal cord were also analyzed...
  6. Zhou W, Bao W, Jiang D, Kong Y, Hua F, Lu X, et al. [18F]-GE-179 positron emission tomography (PET) tracer for N-methyl-d-aspartate receptors: One-pot synthesis and preliminary micro-PET study in a rat model of MCAO. Nucl Med Biol. 2018;61:45-55 pubmed publisher
    ..Immunofluorescence staining of NMDAR NR1 subunit in brain slices containing lesion was also performed...
  7. Gomaa A, Makboul R, El Mokhtar M, Abdel Rahman E, Ahmed I, Nicola M. Terpenoid-rich Elettaria cardamomum extract prevents Alzheimer-like alterations induced in diabetic rats via inhibition of GSK3β activity, oxidative stress and pro-inflammatory cytokines. Cytokine. 2019;113:405-416 pubmed publisher
    ..it elevated the suppressed glutamate receptor expression (AMPA GluR1 subunit and NMDA receptor subunits NR1, NR2A, NR2B)...
  8. Haack K, Zucker I. Central mechanisms for exercise training-induced reduction in sympatho-excitation in chronic heart failure. Auton Neurosci. 2015;188:44-50 pubmed publisher
    ..II and the Type 1 receptor, increased in reactive oxygen stress, upregulation in glutamate signaling and NR1 (N-methyl-D-aspartate subtype 1) receptors and others...
  9. Jung G, Kim E, Cicvaric A, Sase S, Gröger M, Höger H, et al. Drebrin depletion alters neurotransmitter receptor levels in protein complexes, dendritic spine morphogenesis and memory-related synaptic plasticity in the mouse hippocampus. J Neurochem. 2015;134:327-39 pubmed publisher
    ..in hippocampus of drebrin knockout mice whereas no significant changes were detected for GluR1, 2, and 3 and NR1 as examined by native gel-based immunoblotting...
  10. Wang J, Yi M, Chen X, Muhammad I, Liu F, Li R, et al. Effects of colistin on amino acid neurotransmitters and blood-brain barrier in the mouse brain. Neurotoxicol Teratol. 2016;55:32-7 pubmed publisher
    ..acid type A receptor (GABAAR), gamma aminobutyric acid type B receptor (GABABR), N-methyl-d-aspartate 1 receptor (NR1), N-methyl-d-aspartate 2A receptor (NR2A) and N-methyl-d-aspartate 2B receptor (NR2B) in the cerebral cortex...
  11. Wu X, Liu W, Liu Y, Huang Z, Zhang Y, Song X. Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord. Pain. 2011;152:2605-15 pubmed publisher
    ..reversed the inhibitory effects of CRO treatment on the hyperalgesia and allodynia and phosphorylation of NR1 and NR2B receptors and the subsequent activation of Ca(2+)-dependent signals Ca(2+)/calmodulin-dependent kinase II ..
  12. Gu L, Xu H, Wang F, Xu G, Sinha D, Wang J, et al. Erythropoietin exerts a neuroprotective function against glutamate neurotoxicity in experimental diabetic retina. Invest Ophthalmol Vis Sci. 2014;55:8208-22 pubmed publisher
    ..Retinal GS and GLAST expressions were decreased, while the iGluRs, for example, KA1 and NR1, and PAR polymer expression was increased...
  13. Pogorelov V, Rodriguiz R, Cheng J, Huang M, Schmerberg C, Meltzer H, et al. 5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice. Neuropsychopharmacology. 2017;42:2163-2177 pubmed publisher
    ..prepulse inhibition, improved social behavior, and novel object recognition memory in NMDA receptor hypofunctioning NR1-knockdown mice, and were essentially devoid of catalepsy...
  14. Hwang D, Lee B, Kim H, Lee M, Kyung D, Om A, et al. Genome-wide identification of nuclear receptor (NR) superfamily genes in the copepod Tigriopus japonicus. BMC Genomics. 2014;15:993 pubmed publisher
    ..The 7 subfamilies of NRs separate into five major clades (subfamilies NR1, NR2, NR3, NR4, and NR5/6). Although the repertoire of NR members in, T...
  15. Wu H, Yen H, Huang C, Lee Y, Wu S, Lee T, et al. Soluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex. J Biomed Sci. 2015;22:94 pubmed publisher
    ..demonstrated that AUDA treatment increased the expression of the N-methyl-D-aspartate receptor (NMDA) subunits NR1, NR2A, NR2B; the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunits GluR1, GluR2, and ..
  16. Yang Y, Hu L, Xia Y, Jiang C, Miao C, Yang C, et al. Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK. J Neuroinflammation. 2016;13:84 pubmed publisher
    ..The STN was harvested to quantify the changing levels of p-NR1, p-PKC, TNF-?, and IL1-? by western blotting and detect the expression of calcitonin gene-related peptide (CGRP) ..
  17. Nguyen Thi Hoang M, Nguyen Hoan P, Le Van T, McBride A, Ho Dang Trung N, Tran Tan T, et al. First reported cases of anti-NMDA receptor encephalitis in Vietnamese adolescents and adults. J Neurol Sci. 2017;373:250-253 pubmed publisher
    ..investigations, who exhibited dyskinesia, autonomic instability or psychosis were tested for antibodies against the NR1 subunit of the glutamate (type-NMDA) receptor using an indirect immunofluorescence assay...
  18. Kalita J, Kumar V, Misra U, Bora H. Memory and Learning Dysfunction Following Copper Toxicity: Biochemical and Immunohistochemical Basis. Mol Neurobiol. 2018;55:3800-3811 pubmed publisher
    ..N-methyl-D-aspartate receptors (NMDARs) NR1, NR2A, and NR2B were done by real-time polymerase chain reaction...
  19. Kobayashi M, Nishioka K, Takanashi M, Hattori A, Shojima Y, Hayashida A, et al. Anti-NMDA receptor encephalitis due to large-cell neuroendocrine carcinoma of the uterus. J Neurol Sci. 2017;383:72-74 pubmed publisher
    ..The cerebrospinal fluid tested positive for anti-NMDAR antibodies (encoding the NR1 subunit). The patient was diagnosed with paraneoplastic limbic encephalitis due to uterine cancer...
  20. Nasca C, Zelli D, Bigio B, Piccinin S, Scaccianoce S, Nisticò R, et al. Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity. Proc Natl Acad Sci U S A. 2015;112:14960-5 pubmed publisher
    ..down-regulation of the putative presynaptic type 2 metabotropic glutamate (mGlu2) receptors and the postsynaptic NR1/NMDA receptors in the hippocampus and particularly in the dentate gyrus (DG), a region of active neurogenesis and a ..
  21. Moran R, Holt K, Hall R. pCERC3 from a commensal ST95 Escherichia coli: A ColV virulence-multiresistance plasmid carrying a sul3-associated class 1 integron. Plasmid. 2016;84-85:11-9 pubmed publisher
    ..At one end the sequence extends into Tn2670-derived sequence and then into sequence derived from the plasmid NR1 (R100)...
  22. Blanco E, Pavón F, Palomino A, Luque Rojas M, Serrano A, Rivera P, et al. Cocaine-induced behavioral sensitization is associated with changes in the expression of endocannabinoid and glutamatergic signaling systems in the mouse prefrontal cortex. Int J Neuropsychopharmacol. 2014;18: pubmed publisher
    ..KGA), the metabotropic glutamate receptors (mGluR3 and GluR), and subunits of NMDA ionotropic receptors (NR1, NR2A, NR2B and NR2C) after acute cocaine administration, while mice repeatedly exposed to cocaine only displayed ..
  23. Liu M, Shen S, Kendig D, Mahavadi S, Murthy K, Grider J, et al. Inhibition of NMDAR reduces bladder hypertrophy and improves bladder function in cyclophosphamide induced cystitis. J Urol. 2015;193:1676-83 pubmed publisher
    ..NMDAR activity measured by the phosphorylation level of the NMDAR1 (NR1) subunit was expressed in the spinal cord but not in the bladder at 48 hours of cystitis...
  24. Westman G, Studahl M, Ahlm C, Eriksson B, Persson B, Ronnelid J, et al. N-methyl-d-aspartate receptor autoimmunity affects cognitive performance in herpes simplex encephalitis. Clin Microbiol Infect. 2016;22:934-940 pubmed publisher
    ..Anti-NMDAR IgG was detected with HEK293 cells transfected with plasmids encoding the NMDA NR1 type glutamate receptor...
  25. Lin Y, Liang Z, He L, Yang M, Liu D, Gu H, et al. Gut ghrelin regulates hepatic glucose production and insulin signaling via a gut-brain-liver pathway. Cell Commun Signal. 2019;17:8 pubmed publisher
    ..tetracaine, or MK801, an N-methyl-D-aspartate (NMDA) receptor inhibitor, and adenovirus expressing the shRNA of NR1 subunit of NMDA receptors (Ad-shNR1) within the dorsal vagal complex, and hepatic vagotomy in rats...
  26. Anaparti V, Pascoe C, Jha A, Mahood T, Ilarraza R, Unruh H, et al. Tumor necrosis factor regulates NMDA receptor-mediated airway smooth muscle contractile function and airway responsiveness. Am J Physiol Lung Cell Mol Physiol. 2016;311:L467-80 pubmed publisher
    ..We observed dose- and time-dependent changes in NMDA-R composition: increased obligatory NR1 subunit expression and altered regulatory NR2 and inhibitory NR3 subunits...
  27. Anaparti V, Ilarraza R, Orihara K, Stelmack G, Ojo O, Mahood T, et al. NMDA receptors mediate contractile responses in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2015;308:L1253-64 pubmed publisher
    ..We measured mRNA for a number of NMDA-R subunits, including the obligatory NR1 subunit, which we confirmed to be present as a protein...
  28. Kim N, Choi Y, Lim S, Jeong M, Jin D, Choi C. Effect of salinity changes on olfactory memory-related genes and hormones in adult chum salmon Oncorhynchus keta. Comp Biochem Physiol A Mol Integr Physiol. 2015;187:40-7 pubmed publisher
    ..We examined changes in the expression of three NRs (NR1, NR2B, and NR2C), olfactory receptor (OR), and adrenocorticotropic hormone (ACTH) in chum salmon Oncorhynchus keta ..
  29. Ge C, Wang X, Huang Z, Xia Q, Wang N, Xu D. Tongqiao Huoxue Decoction ameliorates learning and memory defects in rats with vascular dementia by up-regulating the Ca(2+)-CaMKII-CREB pathway. Chin J Nat Med. 2015;13:823-830 pubmed publisher
    ..kinase A(PKA), cAMP-response element binding protein(CREB), and three N-methyl-D-aspartic acid receptor subunits (NR1, NR2A, and NR2B)...
  30. Zhao Y, Liu Y, Li Q, Zhao Y, Wang J, Zhang M, et al. Involvement of trigeminal astrocyte activation in masseter hyperalgesia under stress. Physiol Behav. 2015;142:57-65 pubmed publisher
    ..addition, the expression of interleukin-1β (IL-1β) and phosphorylated N-methyl-d-aspartic acid receptor 1 (p-NR1) in the Vc was significantly increased after chronic restraint stress, whereas LAA dramatically inhibited the ..
  31. Wang Q, Yin P, Yu B, Zhao Z, Richter Levin G, Yu L, et al. Down-regulation of dorsal striatal αCaMKII causes striatum-related cognitive and synaptic disorders. Exp Neurol. 2017;298:112-121 pubmed publisher
    ..acid receptor (AMPAR), and a decline in the expression levels of N-methyl-d-aspartic acid receptor (NMDAR) subunits NR1, NR2A and NR2B...
  32. Du Y, Yang J, Yan B, Bai Y, Zhang L, Zheng L, et al. Lanthanum enhances glutamate-nitric oxide-3',5'-cyclic guanosine monophosphate pathway in the hippocampus of rats. Toxicol Ind Health. 2016;32:1791-800 pubmed publisher
    ..ultrastructure and significantly increased the glutamate level, intracellular calcium ion concentrations, and NR1 and NR2B expression in the hippocampi...
  33. Campana W, Mantuano E, Azmoon P, Henry K, Banki M, Kim J, et al. Ionotropic glutamate receptors activate cell signaling in response to glutamate in Schwann cells. FASEB J. 2017;31:1744-1755 pubmed publisher
    ..of SC signaling by glutamate was blocked by EGTA and dizocilpine and by silencing expression of the NMDA-R NR1 subunit...
  34. Xi Y, Zhang D, Ding J, Yu H, Yuan L, Ma W, et al. Genistein Inhibits Aβ25-35-Induced Synaptic Toxicity and Regulates CaMKII/CREB Pathway in SH-SY5Y Cells. Cell Mol Neurobiol. 2016;36:1151-9 pubmed publisher
    ..In addition, the down-regulation of NR1 and NR2B induced by Aβ25-35 which are subunits of N-methyl-D-aspartate receptor also could be antagonized by pre-..
  35. Ikura T, Katsuse O, Chiba Y, Takahashi Y, Fujishiro H, Kamada A, et al. Evaluation of titers of antibodies against peptides of subunits NR1 and NR2B of glutamate receptor by enzyme-linked immunosorbent assay in psychiatric patients with anti-thyroid antibodies. Neurosci Lett. 2016;628:201-6 pubmed publisher
    ..NMDA-R forms a tetramer with the subunit glutamate receptors (GluR) GluRζ1 (NR1) and GluRε2 (NR2B)...
  36. Wei T, Chen H, Huang X, Weng J, Qin J, Su J. [A study on toxic effects of sodium salicylate on rat cochlear spiral ganglion neurons: dopamine receptors mediate expressions of NMDA and GABAA receptors]. Sheng Li Xue Bao. 2017;69:285-290 pubmed
    ..Western blot was performed to assess NMDA receptor NR1 subunit and GABAA receptor subunit ?2 (GABR?2) protein expressions in the SGNs after the treatments of ..
  37. Schlösser L, Barthel F, Brandenburger T, Neumann E, Bauer I, Eulenburg V, et al. Glycine transporter GlyT1, but not GlyT2, is expressed in rat dorsal root ganglion--Possible implications for neuropathic pain. Neurosci Lett. 2015;600:213-9 pubmed publisher
    ..Expression patterns of GlyTs and the glycine binding subunit NR1 of the N-methyl-d-aspartate (NMDA) receptor in the spinal cord and dorsal root ganglia (DRG) were analyzed by ..
  38. Peng W, Ding J, Li X, Fan F, Zhang Q, Wang X. N-methyl-D-aspartate receptor NR2B subunit involved in depression-like behaviours in lithium chloride-pilocarpine chronic rat epilepsy model. Epilepsy Res. 2016;119:77-85 pubmed publisher
    ..This study is to explore the role of glutamate N-methyl-D-aspartate (NMDA) receptor NR1, NR2A and NR2B subunits in epilepsy-associated depression...
  39. Stamboulian Platel S, Legendre A, Chabrol T, Platel J, Pernot F, Duveau V, et al. Activation of GABAA receptors controls mesiotemporal lobe epilepsy despite changes in chloride transporters expression: In vivo and in silico approach. Exp Neurol. 2016;284:11-28 pubmed publisher
    ..epileptic mice, compared to saline controls, while levels of R1 and R2 GABAB receptor subunits but also NR1, NR2A and NR2B NMDA receptor subunits and GluR1 and GluR2 AMPA receptor subunits were decreased...
  40. Kreye J, Wenke N, Chayka M, Leubner J, Murugan R, Maier N, et al. Human cerebrospinal fluid monoclonal N-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis. Brain. 2016;139:2641-2652 pubmed
    ..Little is known about the cerebrospinal fluid autoantibody repertoire. Antibodies against the NR1 subunit of the NMDAR are thought to be pathogenic; however, direct proof is lacking as previous experiments could ..
  41. Fasoli A, Dang J, Johnson J, Gouw A, Fogli Iseppe A, Ishida A. Somatic and neuritic spines on tyrosine hydroxylase-immunopositive cells of rat retina. J Comp Neurol. 2017;525:1707-1730 pubmed publisher
    ..GluR1, GluR4, NR1, PSD-95, and PSD-93), that TH cell somata and tapering neurites are also immunopositive for a γ-aminobutyric ..
  42. Ning L, Zhang T, Chu J, Qu N, Lin L, Fang Y, et al. Gender-Related Hippocampal Proteomics Study from Young Rats After Chronic Unpredicted Mild Stress Exposure. Mol Neurobiol. 2018;55:835-850 pubmed publisher
    ..Compared with their controls, M-D rats had lower NR1 and higher NR2B, and F-D rats had lower NR2A, NR2B, PSD95, and synapsin1...
  43. Uldrick T, Goncalves P, Wyvill K, Peer C, Bernstein W, Aleman K, et al. A Phase Ib Study of Sorafenib (BAY 43-9006) in Patients with Kaposi Sarcoma. Oncologist. 2017;22:505-e49 pubmed publisher
    ..Sorafenib dose level 1 in cohort R (R1) was 200 mg daily and 200 mg every 12 hours in cohort NR (NR1). Steady-state pharmacokinetics were evaluated at cycle 1, day 8...
  44. Yamazaki H, Jin Y, Tsuchiya A, Kanno T, Nishizaki T. Adipose-derived stem cell-conditioned medium ameliorates antidepression-related behaviors in the mouse model of Alzheimer's disease. Neurosci Lett. 2015;609:53-7 pubmed publisher
    ..ASC-CM did not affect cell surface localization of the N-methyl-d-aspartate (NMDA) receptor subunits NR1, -2A, and -2B both in the hippocampus and hypothalamus of 5xFAD mice...
  45. Biswal S, Das D, Barhwal K, Kumar A, Nag T, Thakur M, et al. Epigenetic Regulation of SNAP25 Prevents Progressive Glutamate Excitotoxicty in Hypoxic CA3 Neurons. Mol Neurobiol. 2017;54:6133-6147 pubmed publisher
    ..Despite increased synaptosomal glutamate and higher expression of NR1 subunit of NMDA receptors, we observed decrease in post-synaptic density and accumulation of synaptic vesicles at ..
  46. Ye L, Xiao L, Yang S, Duan J, Cui Y, Chen Y. Cathepsin S in the spinal microglia contributes to remifentanil-induced hyperalgesia in rats. Neuroscience. 2017;344:265-275 pubmed publisher
    ..LHVS reduced hyperalgesia, attenuated activation of spinal microglia and blocked phosphorylation of NMDA receptor NR1 subunit induced by remifentanil...
  47. Lin C, Hung S, Huang H, Ma M. Blockade of the N-Methyl-D-Aspartate Glutamate Receptor Ameliorates Lipopolysaccharide-Induced Renal Insufficiency. PLoS ONE. 2015;10:e0132204 pubmed publisher
    ..The NMDA receptor NR1 subunit in the rat kidney mainly co-localized with serine racemase, an enzyme responsible for synthesizing the NMDA ..
  48. Mantuano E, Lam M, Shibayama M, Campana W, Gonias S. The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration. J Cell Sci. 2015;128:3478-88 pubmed publisher
    ..The NR1 (encoded by GRIN1) and NR2b (encoded by GRIN2B) NMDA-R subunits were expressed by cultured Schwann cells and ..
  49. Coronel M, Raggio M, Adler N, De Nicola A, Labombarda F, González S. Progesterone modulates pro-inflammatory cytokine expression profile after spinal cord injury: Implications for neuropathic pain. J Neuroimmunol. 2016;292:85-92 pubmed publisher
    ..spinal expression of IL-1β, its receptors (IL-1RI and IL-1RII) and antagonist (IL-1ra), IL-6 and TNFα, and NR1 subunit of NMDAR...
  50. Ran Y, Yan B, Li Z, Ding Y, Shi Y, Le G. Dityrosine administration induces novel object recognition deficits in young adulthood mice. Physiol Behav. 2016;164:292-9 pubmed publisher
    ..Furthermore, we found that dityrosine-ingested mice showed decreased expression level of NMDA receptor subunits Nr1, Nr2a, Nr2b as well as Bdnf, Trkb...
  51. Krzystanek M, Bogus K, Pałasz A, Wiaderkiewicz A, Filipczyk Ł, Rojczyk E, et al. Extended neuroleptic administration modulates NMDA-R subunit immunoexpression in the rat neocortex and diencephalon. Pharmacol Rep. 2016;68:990-5 pubmed publisher
    ..To explore NR1, NR2A and NR2B subunit protein expression, densytometric analysis of immunohistochemically stained brain slices was ..
  52. Pang H, Li M, Wang Y, Tang M, Ma C, Huang J. Effect of compatible herbs on the pharmacokinetics of effective components of Panax notoginseng in Fufang Xueshuantong Capsule. J Zhejiang Univ Sci B. 2017;18:343-352 pubmed publisher
    ..tandem mass spectrometry (HPLC-ESI-MS/MS) method was developed for simultaneous detection of notoginsenoside R1 (NR1), ginsenoside Rg1 (GRg1), and ginsenoside Rb1 (GRb1) in rat plasma...
  53. Kristofikova Z, Ricny J, Sírová J, Ripova D, Lubitz I, Schnaider Beeri M. Differences Between Tg2576 and Wild Type Mice in the NMDA Receptor-Nitric Oxide Pathway After Prolonged Application of a Diet High in Advanced Glycation End Products. Neurochem Res. 2015;40:1709-18 pubmed publisher
    ..After the decapitation of 11-months old mice, brain tissue analyses were performed [expressions of the NR1, NR2A and NR2B subunits of NMDA receptors, activities of neuronal, endothelial and inducible nitric oxide synthase (..
  54. Roshanravan H, Kim E, Dryer S. NMDA Receptors as Potential Therapeutic Targets in Diabetic Nephropathy: Increased Renal NMDA Receptor Subunit Expression in Akita Mice and Reduced Nephropathy Following Sustained Treatment With Memantine or MK-801. Diabetes. 2016;65:3139-50 pubmed publisher
    ..A similar increase in NMDA subunits, especially NR1, NR2A, and NR2C, was observed in glomeruli and tubules of Akita mice...
  55. Zhang X, Yuan X, Chen L, Wei H, Chen J, Li T. The change in retinoic acid receptor signaling induced by prenatal marginal vitamin A deficiency and its effects on learning and memory. J Nutr Biochem. 2017;47:75-85 pubmed publisher
    ..vitamin A deficiency (mVAD)-related impairment in learning and memory and the interactions between RARα, Src and NR1. Learning and memory were assessed in adult rats that were exposed to prenatal mVAD with Morris water maze...
  56. Minaya D, Larson R, Podlasz P, Czaja K. Glutamate-dependent regulation of food intake is altered with age through changes in NMDA receptor phenotypes on vagal afferent neurons. Physiol Behav. 2018;189:26-31 pubmed publisher
    ..Immunofluorescence was used to determine NMDA receptor subunit expression (NR1, NR2B, NR2C, and NR2D) in the NG...
  57. Neuhaus W, Schlundt M, Fehrholz M, Ehrke A, Kunzmann S, Liebner S, et al. Multiple Antenatal Dexamethasone Treatment Alters Brain Vessel Differentiation in Newborn Mouse Pups. PLoS ONE. 2015;10:e0136221 pubmed publisher
    ..the tight junction protein claudin-5, the endothelial marker Pecam-1/CD31, the glucocorticoid receptor, the NR1 subunit of the N-methyl-D-aspartate receptor, and Abc transporters (Abcb1a, Abcg2 Abcc4)...
  58. Santarelli S, Wagner K, Labermaier C, Uribe A, Dournes C, Balsevich G, et al. SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system. Stress. 2016;19:83-90 pubmed publisher
    ..We also provide evidence that GluR1 expression in the dentate gyrus, but not GluR2 or NR1, are regulated by slc6a15 expression, and may contribute to the difference in stress responsiveness observed ..
  59. Wei B, Li L, He A, Zhang Y, Sun M, Xu Z. Hippocampal NMDAR-Wnt-Catenin signaling disrupted with cognitive deficits in adolescent offspring exposed to prenatal hypoxia. Brain Res. 2016;1631:157-64 pubmed publisher
    ..The expressions of subunits of N-methyl-D-aspartate receptors (NMDARs), Grin1/NR1, Grin2a/NR2A, and Grin2b/NR2B, were significantly decreased in the hippocampus of adolescent offspring in the PH ..
  60. Song Q, Deng Y, Yang X, Bai Y, Xu B, Liu W, et al. Manganese-Disrupted Interaction of Dopamine D1 and NMDAR in the Striatum to Injury Learning and Memory Ability of Mice. Mol Neurobiol. 2016;53:6745-6758 pubmed
    ..Mn decreased the immunohistochemical activities, protein levels, and messenger RNA (mRNA) expression of DR1, NR1, and NR2A...
  61. Huang G, Zou B, Lv J, Li T, Huai G, Xiang S, et al. Notoginsenoside R1 attenuates glucose-induced podocyte injury via the inhibition of apoptosis and the activation of autophagy through the PI3K/Akt/mTOR signaling pathway. Int J Mol Med. 2017;39:559-568 pubmed publisher
    ..The aim of this study was to examine the protective effects of notoginsenoside R1 (NR1) on the maintenance of podocyte number and foot process architecture via the inhibition of apoptosis, the induction ..
  62. Roginski R, Lau C, Santoiemma P, Weaver S, Du P, Soteropoulos P, et al. The human GCOM1 complex gene interacts with the NMDA receptor and internexin-alpha. Gene. 2018;648:42-53 pubmed publisher
    ..We showed that Gcom15 interacts with the NR1 subunit of the NMDA receptor by co-expression in heterologous cells, in which we observed bi-directional co-..
  63. Jones G, Soden M, Knakal C, Lee H, Chung A, Merriam E, et al. A genetic link between discriminative fear coding by the lateral amygdala, dopamine, and fear generalization. elife. 2015;4: pubmed publisher
    ..Here, we utilized mice with a selective genetic inactivation functional NMDARs in dopamine neurons (DAT-NR1 KO mice) combined with behavior, in vivo electrophysiology, and ex vivo electrophysiology in LA neurons to ..
  64. Yang J, Hertz E, Zhang X, Leinartaité L, Lundius E, Li J, et al. Overexpression of α-synuclein simultaneously increases glutamate NMDA receptor phosphorylation and reduces glucocerebrosidase activity. Neurosci Lett. 2016;611:51-8 pubmed publisher
    ..of α-syn in transgenic mice leads to increased phosphorylation of glutamate NMDA receptor (NMDAR) subunits NR1 and NR2B in substantia nigra and striatum as well as reduced glucocerebrosidase (GCase) levels...
  65. Arboleya S, Clemente A, Deng S, Bedmar M, Salvador I, Herbera P, et al. Anti-NMDAR antibodies in new-onset psychosis. Positive results in an HIV-infected patient. Brain Behav Immun. 2016;56:56-60 pubmed publisher
    ..Our goal was to evaluate the prevalence of IgG antibodies against the NMDAR NR1 subunit (NMDAR-Abs) along with five additional NSAs in 61 first psychotic episode patients and 47 matched controls...
  66. Wang Y, Ma Y, Hu J, Zhang X, Cheng W, Jiang H, et al. Sex-specific effects of prenatal chronic mild stress on adult spatial learning capacity and regional glutamate receptor expression profiles. Exp Neurol. 2016;281:66-80 pubmed publisher
    ..Male PCMS-exposed offspring exhibited elevated basal expression of NR1, mGluR5, and mGluR2/3 in the prefrontal cortex (PFC), whereas females showed no basal expression changes...
  67. Fang C, Li Q, Min G, Liu M, Cui J, Sun J, et al. MicroRNA-181c Ameliorates Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats. Mol Neurobiol. 2017;54:8370-8385 pubmed publisher
    ..resulting in remodeling of the hippocampal neurons as well as increase in N-methyl-D-aspartate receptor 1 (NR1) subunit cell surface expression. Meanwhile, miR-181c might rescue the cellular activity from ischemia/hypoxia...
  68. Costello D, Claret M, Al Qassab H, Plattner F, Irvine E, Choudhury A, et al. Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity. PLoS ONE. 2012;7:e31124 pubmed publisher
    ..These plasticity changes are associated with reduced basal phosphorylation of the NMDA receptor subunit NR1 and of downstream targets of the PI3K pathway, the protein kinases Akt and GSK-3β...
  69. Anderson E, Reeves T, Kapernaros K, Neubert J, Caudle R. Phosphorylation of the N-methyl-d-aspartate receptor is increased in the nucleus accumbens during both acute and extended morphine withdrawal. J Pharmacol Exp Ther. 2015;355:496-505 pubmed publisher
    ..We discovered an increase in phosphorylation of serine 897 in the NR1 subunit of the NMDA receptor (pNR1) during acute morphine withdrawal...
  70. Nibber A, Clover L, Pettingill P, Waters P, Elger C, Bien C, et al. Antibodies to AMPA receptors in Rasmussen's encephalitis. Eur J Paediatr Neurol. 2016;20:222-227 pubmed publisher
    ..encephalitis were tested by cell-based assays for antibodies to AMPAR GluA1/2/3, N-methyl-d-aspartate (NMDA NR1/2b), γ-aminobutyric acid type A and B (GABAAR α1/γ2/β2 and GABABR b1/b2) receptors, for potassium ..
  71. Lu K, Yang J, Hsieh C, Hsu Y, Lin Y. Electroacupuncture restores spatial learning and downregulates phosphorylated N-methyl-D-aspartate receptors in a mouse model of Parkinson's disease. Acupunct Med. 2017;35:133-141 pubmed publisher
    ..In PD mice, phosphorylated NMDA receptor subunits NR1 and NR2B were elevated (134.03±10.17% and 123.46±3...
  72. Li B, Liu P, Chu Z, Shang Y, Huan M, Dang Y, et al. Social isolation induces schizophrenia-like behavior potentially associated with HINT1, NMDA receptor 1, and dopamine receptor 2. Neuroreport. 2017;28:462-469 pubmed publisher
    ..behavior and used enzyme-linked immunosorbent assays to investigate the expression levels of HINT1, the NR1 subunit of N-methyl-D-aspartate acid receptor, and dopamine type 2 receptor (D2R) in C57 mice...
  73. Yamada Goto N, Ochi Y, Katsuura G, Yamashita Y, Ebihara K, Noguchi M, et al. Neuronal cells derived from human induced pluripotent stem cells as a functional tool of melanocortin system. Neuropeptides. 2017;65:10-20 pubmed publisher
    ..and postsynaptic density protein 95) and for subunits of various excitatory and inhibitory transmitters (NR1, NR2A, NR2B, GABAA ?1)...
  74. Abu Serie M, Nasser N, Abd El Wahab A, Shehawy R, Pienaar H, Baddour N, et al. In vivo assessment of the hepatotoxicity of a new Nostoc isolate from the Nile River: Nostoc sp. strain NRI. Toxicon. 2018;143:81-89 pubmed publisher
    ..We have previously isolated a Nostoc strain (NR1) from the Nile River (the main water supply in Egypt) and this strain exerted production of rare and highly toxic ..
  75. Cho Y, Kim H, Kim W, Chung S, Kim Y, Cho I, et al. Trafficking patterns of NMDA and GABAA receptors in a Mg2+-free cultured hippocampal neuron model of status epilepticus. Epilepsy Res. 2017;136:143-148 pubmed publisher
    ..Biotinylation assay and immunofluorescence staining for GABAR ?2,3 and NMDAR NR1 subunits were performed to quantify and visualize surface GABARs and NMDARs, respectively...
  76. Rong X, Xiong Z, Cao B, Chen J, Li M, Li Z. Case report of anti-N-methyl-D-aspartate receptor encephalitis in a middle-aged woman with a long history of major depressive disorder. BMC Psychiatry. 2017;17:320 pubmed publisher
    Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disease involving antibodies against the NR1 subunits of NMDARs...
  77. Yuzaki M, Connor J. Characterization of L-homocysteate-induced currents in Purkinje cells from wild-type and NMDA receptor knockout mice. J Neurophysiol. 1999;82:2820-6 pubmed
    ..HCA also activated responses mediated by non-NMDA receptors in both wild-type and NR1(-/-) hippocampal neurons...
  78. Thévenon J, Souchay C, Seabold G, Dygai Cochet I, Callier P, Gay S, et al. Heterozygous deletion of the LRFN2 gene is associated with working memory deficits. Eur J Hum Genet. 2016;24:911-8 pubmed publisher
    ..the localization of LRFN2 at synapses of cerebellar and hippocampal rat neurons, often associated with the NR1 subunit of N-methyl-D-aspartate receptors (NMDARs)...
  79. Ding J, Zhou H, Ma Q, He Z, Ma J, Liu Y, et al. Expression of NR1 and apoptosis levels in the hippocampal cells of mice treated with MK?801. Mol Med Rep. 2017;16:8359-8364 pubmed publisher
    The aim of the present study was to investigate the characteristics of N?methyl?D?aspartate receptor R1 (NR1) expression and apoptosis in the nerve cells of the hippocampus in schizophrenia?like mice...
  80. Paine M, Garner A, Powell D, Sibbald J, Sales M, Pratt N, et al. Cloning and characterization of a novel human dual flavin reductase. J Biol Chem. 2000;275:1471-8 pubmed
    ..Immunoblot analysis of fractionated MCF7 cells with antibodies to recombinant NR1 showed that the enzyme is cytoplasmic and highly expressed in a panel of human cancer cell lines, thus indicating ..
  81. Nam Y, Kim J, Kim J, Jha M, Jung J, Lee M, et al. Reversible Induction of Pain Hypersensitivity following Optogenetic Stimulation of Spinal Astrocytes. Cell Rep. 2016;17:3049-3061 pubmed publisher
    ..induced pain hypersensitivity in a reversible and time-dependent manner, which was accompanied by glial activation, NR1 phosphorylation, ATP release, and the production of proalgesic mediators...
  82. Tang Y, Wang X, Zhang S, Duan S, Qing W, Chen G, et al. Pre-existing weakness is critical for the occurrence of postoperative cognitive dysfunction in mice of the same age. PLoS ONE. 2017;12:e0182471 pubmed publisher
    ..were collected to detect the levels of neuroinflammation, synaptophysin and NMDA receptor subunits NR2A, NR2B and NR1 (by western blot), and oxidative stress (by Dihydroethidium)...
  83. Kwasnicka D, Krakowiak A, Thacker C, Brenner C, Vincent S. Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. J Biol Chem. 2003;278:39051-8 pubmed
    A novel human cytosolic flavin reductase, Nr1, was recently described that contains FMN, FAD, and NADPH cofactors...
  84. Netz D, Stümpfig M, Dore C, Muhlenhoff U, Pierik A, Lill R. Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis. Nat Chem Biol. 2010;6:758-65 pubmed publisher
    ..The pathway is conserved in eukaryotes, as human Ndor1-Ciapin1 proteins can functionally replace yeast Tah18-Dre2.
  85. Liu C, Cheng J, Hung K, Chia Y, Tan P. Lentiviral vector-encoded microRNA-based shRNA-mediated gene knockdown of N-methyl-D-aspartate receptors in skin reduces pain. Brain Behav. 2017;7:e00587 pubmed publisher
    ..effects of gene silencing and antinociception on formalin- and Complete Freund's adjuvant (CFA)-induced pain in rats by subcutaneously injecting a lentiviral vector encoding a shRNAmir that targets the NR1 subunit of the NMDA receptor.
  86. Zhong H, Dang J, Huo Z, Ma Z, Chen J, Huang Y, et al. Effects of medial prefrontal cortex 5-HT7 receptor knockdown on cognitive control after acute heroin administration. Brain Res. 2018;1678:419-431 pubmed publisher
    ..Moreover, 5-HT7R knockdown prevented the heroin-induced decrease in NR1/CaMKII phosphorylation in mPFC, thus suggesting that 5-HT7R and N-methyl-d-aspartic acid (NMDA) receptor ..
  87. Finn R, Basran J, Roitel O, Wolf C, Munro A, Paine M, et al. Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1. Eur J Biochem. 2003;270:1164-75 pubmed
    Human novel reductase 1 (NR1) is an NADPH dependent diflavin oxidoreductase related to cytochrome P450 reductase (CPR)...
  88. Banci L, Bertini I, Calderone V, Ciofi Baffoni S, Giachetti A, Jaiswal D, et al. Molecular view of an electron transfer process essential for iron-sulfur protein biogenesis. Proc Natl Acad Sci U S A. 2013;110:7136-41 pubmed publisher
    ..iron-sulfur protein assembly machinery, two human key proteins--NADPH-dependent diflavin oxidoreductase 1 (Ndor1) and anamorsin--form a stable complex in vivo that was proposed to provide electrons for assembling cytosolic iron-..
  89. Sikora M, Tokarski K, Bobula B, Zajdel J, Jastrzębska K, Cieślak P, et al. NMDA Receptors on Dopaminoceptive Neurons Are Essential for Drug-Induced Conditioned Place Preference. Eneuro. 2016;3: pubmed publisher
    ..We generated a transgenic mouse line with inducible selective inactivation of the NR1 subunit in neurons expressing dopamine D1 receptors (the NR1(D1CreERT2) mice)...
  90. Kwasnicka Crawford D, Vincent S. Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity. Biochem Biophys Res Commun. 2005;336:565-71 pubmed
    ..Recently, a cytosolic NADPH-dependent flavin reductase, NR1, has been described which is highly homologous to the microsomal cytochrome P450 reductase...
  91. Henson M, Larsen R, Lawson S, Pérez Otaño I, Nakanishi N, Lipton S, et al. Genetic deletion of NR3A accelerates glutamatergic synapse maturation. PLoS ONE. 2012;7:e42327 pubmed publisher
    ..observations, we observed that the deletion of NR3A accelerated the expression of the glutamate receptor subunits NR1, NR2A, and GluR1 in the PSD in postnatal day (P) 8 mice...
  92. Shen J, Wang R, He Z, Huang H, He X, Zhou J, et al. NMDA receptors participate in the progression of diabetic kidney disease by decreasing Cdc42-GTP activation in podocytes. J Pathol. 2016;240:149-60 pubmed publisher
    ..N-Methyl-d-aspartate receptors (NMDARs), which consist of two functional NR1 subunits and two regulatory NR2 subunits, are widely expressed in the brain but are also found in podocytes...