NDE1

Summary

Gene Symbol: NDE1
Description: nudE neurodevelopment protein 1
Alias: HOM-TES-87, LIS4, MHAC, NDE, NUDE, NUDE1, nuclear distribution protein nudE homolog 1, LIS1-interacting protein NUDE1, rat homolog, nudE nuclear distribution E homolog 1, nudE nuclear distribution gene E homolog 1
Species: human
Products:     NDE1

Top Publications

  1. Guo J, Yang Z, Song W, Chen Q, Wang F, Zhang Q, et al. Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly. Mol Biol Cell. 2006;17:680-9 pubmed
    ..Moreover, Nudel seems to tether dynactin and dynein to the mother centriole for MT anchoring. ..
  2. Yan X, Li F, Liang Y, Shen Y, Zhao X, Huang Q, et al. Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle. Mol Cell Biol. 2003;23:1239-50 pubmed
    Emerging evidence supports the idea that a signaling pathway containing orthologs of at least mammalian NudE and Nudel, Lis1, and cytoplasmic dynein is conserved for eukaryotic nuclear migration...
  3. Bakircioglu M, Carvalho O, Khurshid M, Cox J, Tuysuz B, Barak T, et al. The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis. Am J Hum Genet. 2011;88:523-35 pubmed publisher
    ..We found two distinct homozygous mutations of NDE1, c.83+1G>T (p.Ala29GlnfsX114) in a Turkish family and c.684_685del (p...
  4. Feng Y, Olson E, Stukenberg P, Flanagan L, Kirschner M, Walsh C. LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome. Neuron. 2000;28:665-79 pubmed
    ..We identified a LIS1 interacting protein encoded by a mouse homolog of NUDE, a nuclear distribution gene in A. nidulans and a multicopy suppressor of the LIS1 homolog, NUDF...
  5. Millar J, Christie S, Porteous D. Yeast two-hybrid screens implicate DISC1 in brain development and function. Biochem Biophys Res Commun. 2003;311:1019-25 pubmed
    ..Intriguingly, mutations in one of the proteins identified, WKL1, have been previously suggested to underlie the aetiology of catatonic schizophrenia. ..
  6. Hirohashi Y, Wang Q, Liu Q, Li B, Du X, Zhang H, et al. Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation. Oncogene. 2006;25:6048-55 pubmed
    ..yeast two-hybrid screens and isolated a number of Su48-interacting molecules, including the centrosomal protein Nde1. Here, we demonstrate that Su48 can associate with Nde1...
  7. Hennah W, Tomppo L, Hiekkalinna T, Palo O, Kilpinen H, Ekelund J, et al. Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1. Hum Mol Genet. 2007;16:453-62 pubmed
    ..loci displayed an evidence of linkage (LOD > 3) and included a locus on 16p13, proximal to the gene encoding NDE1, which has been shown to biologically interact with DISC1...
  8. Derewenda U, Tarricone C, Choi W, Cooper D, Lukasik S, Perrina F, et al. The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly. Structure. 2007;15:1467-81 pubmed
    Ndel1 and Nde1 are homologous and evolutionarily conserved proteins, with critical roles in cell division, neuronal migration, and other physiological phenomena...
  9. Lam C, Vergnolle M, Thorpe L, Woodman P, Allan V. Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning. J Cell Sci. 2010;123:202-12 pubmed publisher
    LIS1, NDE1 and NDEL1 modulate cytoplasmic dynein function in several cellular contexts. However, evidence that they regulate dynein-dependent organelle positioning is limited...

More Information

Publications129 found, 100 shown here

  1. Guven A, Gunduz A, Bozoglu T, Yalcinkaya C, Tolun A. Novel NDE1 homozygous mutation resulting in microhydranencephaly and not microlyssencephaly. Neurogenetics. 2012;13:189-94 pubmed publisher
    Lissencephaly is characterized by deficient cortical lamination. Recently homozygous NDE1 mutations were reported in three kindred afflicted with extreme microcephaly with lissencephaly or microlissencephaly...
  2. Vergnolle M, Taylor S. Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes. Curr Biol. 2007;17:1173-9 pubmed
    ..Here, we show that Cenp-F interacts with Ndel1 and Nde1, two human NudE-related proteins implicated in regulating Lis1/Dynein motor complexes (reviewed in [8])...
  3. Pawlisz A, Mutch C, Wynshaw Boris A, Chenn A, Walsh C, Feng Y. Lis1-Nde1-dependent neuronal fate control determines cerebral cortical size and lamination. Hum Mol Genet. 2008;17:2441-55 pubmed publisher
    ..Here we show that LIS1 and its binding protein Nde1 (mNudE) regulate the fate of radial glial progenitors collaboratively...
  4. Bradshaw N, Ogawa F, Antolin Fontes B, Chubb J, Carlyle B, Christie S, et al. DISC1, PDE4B, and NDE1 at the centrosome and synapse. Biochem Biophys Res Commun. 2008;377:1091-6 pubmed publisher
    ..Its protein binding partners include the Nuclear Distribution Factor E Homologs (NDE1 and NDEL1), LIS1, and phosphodiesterases 4B and 4D (PDE4B and PDE4D)...
  5. Alkuraya F, Cai X, Emery C, Mochida G, Al Dosari M, Felie J, et al. Human mutations in NDE1 cause extreme microcephaly with lissencephaly [corrected]. Am J Hum Genet. 2011;88:536-47 pubmed publisher
    ..a condition referred to as microlissencephaly, and show that they carry homozygous frameshift mutations in NDE1, which encodes a multidomain protein that localizes to the centrosome and mitotic spindle poles...
  6. Efimov V, Morris N. The LIS1-related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein. J Cell Biol. 2000;150:681-8 pubmed
    ..We screened for multicopy suppressors of a mutation in the nudF gene. The product of the nudE gene isolated in the screen, NUDE, is a homologue of the nuclear distribution protein RO11 of Neurospora crassa...
  7. Burdick K, Kamiya A, Hodgkinson C, Lencz T, DeRosse P, Ishizuka K, et al. Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding. Hum Mol Genet. 2008;17:2462-73 pubmed publisher
    ..Intact functions of DISC1 and its binding partners, NDEL1 and NDE1, are critical to neurodevelopmental processes aberrant in schizophrenia (SZ)...
  8. Bradshaw N, Christie S, Soares D, Carlyle B, Porteous D, Millar J. NDE1 and NDEL1: multimerisation, alternate splicing and DISC1 interaction. Neurosci Lett. 2009;449:228-33 pubmed publisher
    Nuclear Distribution Factor E Homolog 1 (NDE1) and NDE-Like 1 (NDEL1) are highly homologous mammalian proteins. However, whereas NDEL1 is well studied, there is remarkably little known about NDE1...
  9. Liu T, Yang H, Fan W, Tu J, Li T, Wang J, et al. Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. Gastroenterology. 2018;155:557-571.e14 pubmed publisher
    ..Incubation of human liver and biliary cancer cells lines with OCA promoted their proliferation; in nude mice given OCA, xenograft tumors were larger than in mice given vehicle...
  10. Hua F, Shang S, Yang Y, Zhang H, Xu T, Yu J, et al. TRIB3 Interacts With β-Catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis. Gastroenterology. 2019;156:708-721.e15 pubmed publisher
    ..Proteins that interact with TRIB3 were identified by immunoprecipitation. CRC cell lines were grown in nude mice as xenograft tumors...
  11. Wang L, Yin J, Wang X, Shao M, Duan F, Wu W, et al. C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits. Gastroenterology. 2016;150:1183-1195.e16 pubmed publisher
    ..Cells were injected into lateral tail vein of BALB/C nude mice; some mice were also given injections of the phosphoinositide 3-kinase (PI3K) inhibitor LY294002...
  12. Shen J, Cao S, Sun X, Pan B, Cao J, Che D, et al. Sinoporphyrin Sodium-Mediated Sonodynamic Therapy Inhibits RIP3 Expression and Induces Apoptosis in the H446 Small Cell Lung Cancer Cell Line. Cell Physiol Biochem. 2018;51:2938-2954 pubmed publisher
    ..To verify the in vitro results, we detected tumor volumes and weight changes in a xenograft nude mouse model after DVDMS-SDT...
  13. He C, Yu T, Shi Y, Ma C, Yang W, Fang L, et al. MicroRNA 301A Promotes Intestinal Inflammation and Colitis-Associated Cancer Development by Inhibiting BTG1. Gastroenterology. 2017;152:1434-1448.e15 pubmed publisher
    ..SW480 cells expressing the MIR301A transgene were grown as xenograft tumors in nude mice. Expression of MIR301A increased in IECs from patients with IBD and CAC compared with controls...
  14. Xie Y, Zhu S, Zhong M, Yang M, Sun X, Liu J, et al. Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma. Gastroenterology. 2017;153:1429-1443.e5 pubmed publisher
    ..Athymic nude or B6 mice were given subcutaneous injections of PDAC cells or tail-vein injections of KPC tumor cells...
  15. Wang M, Chen L, Huang W, Jin M, Wang Q, Gao Z, et al. Improving the anti-keloid outcomes through liposomes loading paclitaxel-cholesterol complexes. Int J Nanomedicine. 2019;14:1385-1400 pubmed
    ..that the PTXL had better performance on inhibiting the keloids growth compared to the PTX in keloid-bearing BALB/c nude mice model...
  16. Shi C, Yang X, Bu X, Hou N, Chen P. Alpha B-crystallin promotes the invasion and metastasis of colorectal cancer via epithelial-mesenchymal transition. Biochem Biophys Res Commun. 2017;489:369-374 pubmed publisher
    ..in Si-CRYAB cells using flow cytometry (FCM), and the tumorigenic capability of Si-CRYAB cells was assessed in a nude mouse tumor model...
  17. Zhuo W, Liu Y, Li S, Guo D, Sun Q, Jin J, et al. Long Noncoding RNA GMAN, Up-regulated in Gastric Cancer Tissues, Is Associated With Metastasis in Patients and Promotes Translation of Ephrin A1 by Competitively Binding GMAN-AS. Gastroenterology. 2019;156:676-691.e11 pubmed publisher
    ..Cells were injected into the tail veins or spleens of nude mice or SCID mice; lung and liver tissues were collected, and metastases were counted...
  18. Medrano J, Martínez Arroyo A, Sukhwani M, Noguera I, Quiñonero A, Martínez Jabaloyas J, et al. Germ cell transplantation into mouse testes procedure. Fertil Steril. 2014;102:e11-2 pubmed publisher
    ..Research laboratory. Male nude mice (NU-Foxn1(nu))...
  19. Wong C, Qian Y, Li X, Xu J, Kang W, Tong J, et al. SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate. Gastroenterology. 2016;151:945-960.e6 pubmed publisher
    ..DLD1 and HCT116 cells with SLC25A22 knockdown were grown as xenograft tumors in nude mice; tumor growth and metastasis were measured...
  20. Yang Y, Weng W, Peng J, Hong L, Yang L, Toiyama Y, et al. Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-κB, and Up-regulating Expression of MicroRNA-21. Gastroenterology. 2017;152:851-866.e24 pubmed publisher
    ..CRC cells were incubated with F nucleatum or PBS and injected into BALB/C nude mice; growth of xenograft tumors was measured...
  21. Lan X, Zhao C, Chen X, Zhang P, Zang D, Wu J, et al. Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms. J Hematol Oncol. 2016;9:129 pubmed
    ..NiPT induced apoptosis in CML cells and inhibited the growth of IM-resistant Bcr-Abl-T315I xenografts in nude mice...
  22. Zhao P, Chen L, Li L, Wei Z, Tong B, Jia Y, et al. SC-III3, a novel scopoletin derivative, induces cytotoxicity in hepatocellular cancer cells through oxidative DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation. BMC Cancer. 2014;14:987 pubmed publisher
    ..Human hepatocellular carcinoma cell line HepG2 cells and xenograft of HepG2 cells in BALB/c nude mice were used to investigate the effects of SC-III3 on hepatocellular cancers...
  23. Peng K, Kou L, Yu L, Bai C, Li M, Mo P, et al. Histone Demethylase JMJD2D Interacts With β-Catenin to Induce Transcription and Activate Colorectal Cancer Cell Proliferation and Tumor Growth in Mice. Gastroenterology. 2019;156:1112-1126 pubmed publisher
    ..Cells were also grown as tumor xenografts in nude mice or injected into tail veins or spleens of mice, and metastases were measured...
  24. He Y, Zou L, Gao M, Liang T, Zou X. [Integrative analysis of gene expression profile and DNA methylation profile of long-term cultivated porcine bone marrow mesenchymal stem cells]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2018;32:1066-1073 pubmed publisher
    ..and transformation properties such as anchorage-independent growth, chromosomal abnormality, and tumor formation in nude mice...
  25. Lee H, Lee M, Lee Y, Choi S, Yang J. Chondrocyte-derived extracellular matrix suppresses pathogenesis of human pterygium epithelial cells by blocking the NF-?B signaling pathways. Mol Vis. 2016;22:1490-1502 pubmed
    ..have reported that chondrocyte-derived extracellular matrix (CDECM) suppresses the growth of pterygium in athymic nude mice...
  26. Alshenibr W, Tashkandi M, Alsaqer S, Alkheriji Y, Wise A, Fulzele S, et al. Anabolic role of lysyl oxidase like-2 in cartilage of knee and temporomandibular joints with osteoarthritis. Arthritis Res Ther. 2017;19:179 pubmed publisher
    ..To examine LOXL2-induced effect in vivo, we implanted Matrigel-imbedded human chondrocytes into nude mice and exposed them to exogenous LOXL2 for 6 weeks...
  27. Dong S, Qu X, Li W, Zhong X, Li P, Yang S, et al. The long non-coding RNA, GAS5, enhances gefitinib-induced cell death in innate EGFR tyrosine kinase inhibitor-resistant lung adenocarcinoma cells with wide-type EGFR via downregulation of the IGF-1R expression. J Hematol Oncol. 2015;8:43 pubmed publisher
    ..A549 cells transfected with pcDNA-GAS5 were injected into nude mice...
  28. Anbalagan M, Sheng M, Fleischer B, Zhang Y, Gao Y, Hoang V, et al. Dual Src Kinase/Pretubulin Inhibitor KX-01, Sensitizes ERα-negative Breast Cancers to Tamoxifen through ERα Reexpression. Mol Cancer Res. 2017;15:1491-1502 pubmed publisher
    ..mg/kg body weight-twice daily) inhibited growth of tamoxifen-resistant MDA-MB-231 and MDA-MB-157 TNBC xenografts in nude mice that was correlated with Src kinase inhibition...
  29. Cao P, Yang A, Wang R, Xia X, Zhai Y, Li Y, et al. Germline Duplication of SNORA18L5 Increases Risk for HBV-related Hepatocellular Carcinoma by Altering Localization of Ribosomal Proteins and Decreasing Levels of p53. Gastroenterology. 2018;155:542-556 pubmed publisher
    ..Formation of xenograft tumors from cell lines was monitored in nude mice...
  30. Ishimoto T, Miyake K, Nandi T, Yashiro M, Onishi N, Huang K, et al. Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells. Gastroenterology. 2017;153:191-204.e16 pubmed publisher
    ..b>Nude mice were given injections of OCUM-2MD3 in the stomach wall; tumors and metastases were collected and analyzed by ..
  31. Fourniols T, Randolph L, Staub A, Vanvarenberg K, Leprince J, Préat V, et al. Temozolomide-loaded photopolymerizable PEG-DMA-based hydrogel for the treatment of glioblastoma. J Control Release. 2015;210:95-104 pubmed publisher
    ..In vivo, the anti-tumor efficacy of TMZ-hydrogel was evaluated on xenograft U87MG tumor-bearing nude mice...
  32. Li Y, Tian X, Sui C, Jiang Y, Liu Y, Meng F. Interference of lysine-specific demethylase 1 inhibits cellular invasion and proliferation in vivo in gastric cancer MKN-28 cells. Biomed Pharmacother. 2016;82:498-508 pubmed publisher
    ..In vivo, the effect of knocking down LSD1 on tumor growth and protein expression in gastric cancer cells in nude mice was investigated...
  33. Wang Y, Chu Y, Yue B, Ma X, Zhang G, Xiang H, et al. Adipose-derived mesenchymal stem cells promote osteosarcoma proliferation and metastasis by activating the STAT3 pathway. Oncotarget. 2017;8:23803-23816 pubmed publisher
    ..In addition, a nude mouse model of osteosarcoma was established by injecting luciferase-labelled MG63 cells into the tibia...
  34. Lim H, Kim J, Park C, Lee S, Lee M, Kim K, et al. Regulation of c-Myc Expression by Ahnak Promotes Induced Pluripotent Stem Cell Generation. J Biol Chem. 2016;291:752-61 pubmed publisher
    ..Moreover, injection of Ahnak(-/-)-iPSC-3F into athymic nude mice led to development of teratoma containing tissues from all three primary germ layers, indicating that iPSC ..
  35. Hu Y, Sun Z, Deng J, Hu B, Yan W, Wei H, et al. Splicing factor hnRNPA2B1 contributes to tumorigenic potential of breast cancer cells through STAT3 and ERK1/2 signaling pathway. Tumour Biol. 2017;39:1010428317694318 pubmed publisher
    ..A nude mouse xenograft model was established to elucidate the function of hnRNPA2B1 in tumorigenesis in vivo...
  36. Fort R, Mathó C, Geraldo M, Ottati M, Yamashita A, Saito K, et al. Nc886 is epigenetically repressed in prostate cancer and acts as a tumor suppressor through the inhibition of cell growth. BMC Cancer. 2018;18:127 pubmed publisher
    ..line leads to a decreased in vitro cell proliferation and invasion, as well as a reduced in vivo cell growth in NUDE-mice tumor xenografts...
  37. Shao F, Lv M, Zheng Y, Jiang J, Wang Y, Lv L, et al. The anti-tumour activity of rLj-RGD4, an RGD toxin protein from Lampetra japonica, on human laryngeal squamous carcinoma Hep-2 cells in nude mice. Biochimie. 2015;119:183-91 pubmed publisher
    ..antiproliferative activity and mechanism of integrin-binding rLj-RGD4 in a Hep-2 human laryngeal carcinoma-bearing nude mouse model...
  38. Peng Y, Zhang X, Ma Q, Yan R, Qin Y, Zhao Y, et al. MiRNA-194 activates the Wnt/?-catenin signaling pathway in gastric cancer by targeting the negative Wnt regulator, SUFU. Cancer Lett. 2017;385:117-127 pubmed publisher
    ..Inhibition of miRNA-194 decreased tumor volumes in nude mice...
  39. Zhang L, Zhao H, Cui Z, Lv Y, Zhang W, Ma X, et al. A peptide derived from apoptin inhibits glioma growth. Oncotarget. 2017;8:31119-31132 pubmed publisher
    ..ADP treatment inhibited xenograft tumor growth and increased the overall health and survival of nude mice implanted with GBM cells...
  40. Sun R, Zhai R, Ma C, Wei M. The anti-growth and anti-metastasis effects of Schisandrin B on hepatocarcinoma cells in vitro and in vivo. Biochem Biophys Res Commun. 2017;: pubmed publisher
    ..Moreover, Sch B significantly inhibited the HCC xenograft model growth in BALB/c nude mice...
  41. Samykutty A, Shetty A, Dakshinamoorthy G, Bartik M, Johnson G, Webb B, et al. Piperine, a Bioactive Component of Pepper Spice Exerts Therapeutic Effects on Androgen Dependent and Androgen Independent Prostate Cancer Cells. PLoS ONE. 2013;8:e65889 pubmed publisher
    ..show that piperine treatment significantly reduced the androgen dependent and androgen independent tumor growth in nude mice model xenotransplanted with prostate cancer cells...
  42. Zheng J, Qiao L, Sun X, Qi J, Ren H, Wei G, et al. Overexpression of caudal-related homeobox transcription factor 2 inhibits the growth of transplanted colorectal tumors in nude mice. Mol Med Rep. 2015;12:3409-3415 pubmed publisher
    ..of the overexpression of CDX2 on subcutaneously?transplanted tumors, derived from LoVo colon cancer cells, in nude mice, and to provide experimental evidence for the biotherapy of colon cancer...
  43. Bamba T, Hasunuma T, Kondo A. Disruption of PHO13 improves ethanol production via the xylose isomerase pathway. AMB Express. 2016;6:4 pubmed publisher
    ..involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YΔGP/XK/XI ..
  44. Xia J, Huang N, Huang H, Sun L, Dong S, Su J, et al. Voltage-gated sodium channel Nav 1.7 promotes gastric cancer progression through MACC1-mediated upregulation of NHE1. Int J Cancer. 2016;139:2553-69 pubmed publisher
    ..pH, and ultimately, reduced invasion and proliferation rates of GC cells and growth of GC xenografts in nude mice. Nav 1...
  45. Zeng D, Sun Q, Chen A, Fan J, Yang X, Xu L, et al. A fully human anti-CD47 blocking antibody with therapeutic potential for cancer. Oncotarget. 2016;7:83040-83050 pubmed publisher
    ..or even stronger than B6H12, phagocytosis of leukemic cancer cells by macrophage in vitro, and protect BALB/c nude mice from cancer killing by engrafted leukemic cells (CCRF and U937) to a similar extent as B6H12 did...
  46. Zhang Y, Liu Y, Zou J, Yan L, Du W, Zhang Y, et al. Tetrahydrocurcumin induces mesenchymal-epithelial transition and suppresses angiogenesis by targeting HIF-1? and autophagy in human osteosarcoma. Oncotarget. 2017;8:91134-91149 pubmed publisher
    ..THC significantly reduced the growth of osteosarcoma cells and suppressed migration and invasion, as tested in a nude mouse lung metastasis model...
  47. Nedrow J, Latoche J, Day K, Modi J, Ganguly T, Zeng D, et al. Targeting PSMA with a Cu-64 Labeled Phosphoramidate Inhibitor for PET/CT Imaging of Variant PSMA-Expressing Xenografts in Mouse Models of Prostate Cancer. Mol Imaging Biol. 2016;18:402-10 pubmed publisher
    ..PET/X-ray computed tomography imaging was performed in NCr nude mice with subcutaneous tumors of the variant PSMA-expressing cell lines...
  48. García Pascual C, Ferrero H, Juarez I, Martínez J, Villanueva A, Pozuelo Rubio M, et al. Evaluation of the antiproliferative, proapoptotic, and antiangiogenic effects of a double-stranded RNA mimic complexed with polycations in an experimental mouse model of leiomyoma. Fertil Steril. 2016;105:529-38 pubmed publisher
    ..Heterologous leiomyoma mouse model. University-affiliated infertility center. Ovariectomized and hormone-replaced nude mice (n = 16) who received human leiomyoma fragment transplantation...
  49. Wang P, Song Y, Weir M, Sun J, Zhao L, Simon C, et al. A self-setting iPSMSC-alginate-calcium phosphate paste for bone tissue engineering. Dent Mater. 2016;32:252-63 pubmed publisher
    ..Microbeads were mixed with CPC paste and filled into cranial defects in nude rats...
  50. Cui L, Nakano K, Obchoei S, Setoguchi K, Matsumoto M, Yamamoto T, et al. Small Nucleolar Noncoding RNA SNORA23, Up-Regulated in Human Pancreatic Ductal Adenocarcinoma, Regulates Expression of Spectrin Repeat-Containing Nuclear Envelope 2 to Promote Growth and Metastasis of Xenograft Tumors in Mice. Gastroenterology. 2017;153:292-306.e2 pubmed publisher
    ..Mice were given intrasplenic injections of MIA PaCa2- or Suit2-HLMC cells; tumor-bearing nude mice were then given 3 weekly injections of an antisense oligonucleotides against SNORA23, a H/ACA-box type snoRNA, ..
  51. Zhu W, Wang Y, Zhang D, Yu X, Leng X. MiR-7-5p functions as a tumor suppressor by targeting SOX18 in pancreatic ductal adenocarcinoma. Biochem Biophys Res Commun. 2018;497:963-970 pubmed publisher
    ..The nude mouse tumorigenicity assay further proved that miR-7-5p targeted SOX18 to inhibit pancreatic cancer growth in ..
  52. Xie Y, Wu J, Xu A, Ahmeqd S, Sami A, Chibbar R, et al. Heterologous human/rat HER2-specific exosome-targeted T cell vaccine stimulates potent humoral and CTL responses leading to enhanced circumvention of HER2 tolerance in double transgenic HLA-A2/HER2 mice. Vaccine. 2018;36:1414-1422 pubmed publisher
    ..BT474/A2 breast tumor cells in vitro but also eradicates pre-established BT474/A2 tumors in athymic nude mice...
  53. Wu C, Zhang J, Xie C, Parolini O, Silini A, Huang Y, et al. In vivo tracking of human placenta derived mesenchymal stem cells in nude mice via ¹⁴C-TdR labeling. BMC Biotechnol. 2015;15:55 pubmed publisher
    ..herein investigated the bio-distribution of human placental deciduas basalis derived MSCs (termed as PDB-MSCs) in nude mice after intravenous injection by carbon radioisotope labeling thymidine ((14)C-TdR), which is able to ..
  54. Liang B, Xiong M, Ji G, Zhang E, Zhang Z, Dong K, et al. Synergistic suppressive effect of PARP-1 inhibitor PJ34 and HDAC inhibitor SAHA on proliferation of liver cancer cells. J Huazhong Univ Sci Technolog Med Sci. 2015;35:535-540 pubmed publisher
    ..The nude mice bearing subcutaneous HepG2 tumors were administered different groups of drugs (10 mg/kg PJ34, 25 mg/kg SAHA, ..
  55. Paulmurugan R, Bhethanabotla R, Mishra K, Devulapally R, Foygel K, Sekar T, et al. Folate Receptor-Targeted Polymeric Micellar Nanocarriers for Delivery of Orlistat as a Repurposed Drug against Triple-Negative Breast Cancer. Mol Cancer Ther. 2016;15:221-31 pubmed publisher
    ..improved the delivery and bioavailability of orlistat to MDA-MB-231 cells in culture and to tumor xenografts in a nude mouse model...
  56. Renier C, Do J, Reyna Neyra A, Foster D, De A, Vogel H, et al. Regression of experimental NIS-expressing breast cancer brain metastases in response to radioiodide/gemcitabine dual therapy. Oncotarget. 2016;7:54811-54824 pubmed publisher
    ..b>Nude mice mammary fat-pad (MFP) tumors and BCBMs were generated with braintropic MDA-MB-231Br cells transduced with ..
  57. Irtenkauf S, Sobiechowski S, Hasselbach L, Nelson K, Transou A, Carlton E, et al. Optimization of Glioblastoma Mouse Orthotopic Xenograft Models for Translational Research. Comp Med. 2017;67:300-314 pubmed
    ..cancer stem cells (CSC) cultured from fresh surgical specimens intracranially into 8-wk-old female athymic nude mice...
  58. Lütje S, Gerrits D, Molkenboer Kuenen J, Herrmann K, Fracasso G, Colombatti M, et al. Characterization of Site-Specifically Conjugated Monomethyl Auristatin E- and Duocarmycin-Based Anti-PSMA Antibody-Drug Conjugates for Treatment of PSMA-Expressing Tumors. J Nucl Med. 2018;59:494-501 pubmed publisher
    ..5 ± 2.6 MBq) with 25 μg of 111In-labeled ADCs were performed on BALB/c nude mice with subcutaneous PSMA-positive LS174T-PSMA xenografts...
  59. Amor Coarasa A, Kelly J, Ponnala S, Vedvyas Y, Nikolopoulou A, Williams C, et al. [18F]RPS-544: A PET tracer for imaging the chemokine receptor CXCR4. Nucl Med Biol. 2018;60:37-44 pubmed publisher
    ..Imaging and biodistribution was performed in nude mice with bilateral PC3 (CXCR4+ and WT) xenograft tumors at 1, 2 and 4 h post injection...
  60. Chi Y, Huang S, Peng H, Liu M, Zhao J, Shao Z, et al. Critical role of CDK11(p58) in human breast cancer growth and angiogenesis. BMC Cancer. 2015;15:701 pubmed publisher
    ..CDK11(p58) inhibited breast cancer growth and angiogenesis in breast cancer cells and in nude mice transplanted with tumors...
  61. Peng Y, Zhong Y, Li G. Tubeimoside-1 suppresses breast cancer metastasis through downregulation of CXCR4 chemokine receptor expression. BMB Rep. 2016;49:502-7 pubmed
    ..The effect of TBMS1 on breast cancer metastasis was further evaluated in a metastasis model of nude mice. TBMS1 suppressed the expression of CXCR4 through inhibition of NF-?B binding activity...
  62. Wang B, Lee W, Huang B, Zhang J, Wu T, Jiang X, et al. Secretome of Human Fetal Mesenchymal Stem Cell Ameliorates Replicative Senescen. Stem Cells Dev. 2016;25:1755-1766 pubmed
    ..In nude mice, HFS pretreatment restored the osteogenic ability of senescent hAMSC...
  63. He L, Fan F, Hou X, Gao C, Meng L, Meng S, et al. Resveratrol suppresses pulmonary tumor metastasis by inhibiting platelet-mediated angiogenic responses. J Surg Res. 2017;217:113-122 pubmed publisher
    ..A pulmonary metastasis experiment with male nude mice model was performed to test the effect of RSV on pulmonary metastasis and angiogenesis in vivo...
  64. Wang J, Li Y, Ma F, Zhou H, Ding R, Lu B, et al. Inhibitory effect of Par-4 combined with cisplatin on human Wilms' tumor cells. Tumour Biol. 2017;39:1010428317716689 pubmed publisher
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  76. Liang L, Li Z, Ma T, Han Z, Du W, Geng J, et al. Transplantation of Human Placenta-Derived Mesenchymal Stem Cells Alleviates Critical Limb Ischemia in Diabetic Nude Rats. Cell Transplant. 2017;26:45-61 pubmed publisher
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    To investigate the inhibitory effect of MenSC-sTRAIL on the apoptosis of A549 cells of lung cancer in a nude mouse model and the relevant molecular mechanism...
  86. Xiong H, Zhang Y, Chen S, Ni Z, HE J, Li X, et al. Induction of SOCS3 by liver X receptor suppresses the proliferation of hepatocellular carcinoma cells. Oncotarget. 2017;8:64083-64094 pubmed publisher
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    ..More importantly, in nude mice model, Met and Cis in combination displayed more efficient inhibition of tumor weight and volume in the SGC-..
  90. Sugimoto Y, Sawant D, Fisk H, Mao L, Li C, Chettiar S, et al. Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer. Bioorg Med Chem. 2017;25:2156-2166 pubmed publisher
    ..The most promising analog, compound 13, significantly decreased tumor growth in nude mice containing Cal-51 triple negative breast cancer cell xenografts...
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    ..Finally, a nude mouse tumorigenicity model was used to examine the biological effect of diallyl trisulfide in vivo...
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    ..In vivo tumor growth was determined in athymic nude mice by injecting the HCT116 cells in the subcutaneous tissue, followed by the injection of QGY-5-114-A...