NDC1

Summary

Gene Symbol: NDC1
Description: NDC1 transmembrane nucleoporin
Alias: NET3, TMEM48, nucleoporin NDC1, nuclear division cycle 1 homolog, transmembrane protein 48
Species: human
Products:     NDC1

Top Publications

  1. Schirmer E, Florens L, Guan T, Yates J, Gerace L. Nuclear membrane proteins with potential disease links found by subtractive proteomics. Science. 2003;301:1380-2 pubmed
    ..Furthermore, 23 of these mapped within chromosome regions linked to a variety of dystrophies. ..
  2. Liu S, Cui P, Wang J, Zhou H, Liu Q, Lv J. Asymmetric transfer hydrogenation of cycloalkyl vinyl ketones to allylic alcohols catalyzed by ruthenium amido complexes. Org Biomol Chem. 2019;17:264-267 pubmed publisher
    ..The reduction proceeded smoothly with a chiral diamine ruthenium complex as a catalyst and a HCOOH-NEt3 azeotrope as both a hydrogen source and solvent under mild conditions...
  3. Mansell S, Russell C, Wass D. Synthesis of chelating diamido Sn(IV) compounds from oxidation of Sn(II) and directly from Sn(IV) precursors. Dalton Trans. 2015;44:9756-65 pubmed publisher
    ..Reaction of (L2)H2 with SnCl4 and NEt3 led to the formation of the diamidotin dichloride [SnCl2(L2)] 4 whereas reaction of (L1)H2 with SnCl4 and NEt3, or [..
  4. Sing T, Hung M, Ohnuki S, Suzuki G, San Luis B, McClain M, et al. The budding yeast RSC complex maintains ploidy by promoting spindle pole body insertion. J Cell Biol. 2018;217:2445-2462 pubmed publisher
    ..More specifically, RSC plays a role in distributing two SPB insertion factors, Nbp1 and Ndc1, to the new SPB...
  5. Akkafa F, Koyuncu I, Temiz E, Dağlı H, Dilmec F, Akbas H. miRNA-mediated apoptosis activation through TMEM 48 inhibition in A549 cell line. Biochem Biophys Res Commun. 2018;503:323-329 pubmed publisher
    ..b>Transmembrane Protein 48 (TMEM48) is localised on nuclear pore complex and plays critic roles in nuclear traffic...
  6. Kruk J, SzymaÅ„ska R, Cela J, Munné Bosch S. Plastochromanol-8: fifty years of research. Phytochemistry. 2014;108:9-16 pubmed publisher
    ..Other enzymes related with PC-8 biosynthesis in plastoglobules include: NDC1 and the ABC1-like kinase ABC1K3...
  7. Fan S, Zong X, Shaw P, Wang X, Geng Y, Smith A, et al. Energetic requirements of iridium(III) complex based photosensitisers in photocatalytic hydrogen generation. Phys Chem Chem Phys. 2014;16:21577-85 pubmed publisher
    ..in aqueous systems, where hydrogen evolution was observed only when the PS* was reduced by the sacrificial agent, NEt3, signifying that a minimum potential difference of >0...
  8. Tziotzi T, Kalofolias D, Tzimopoulos D, Siczek M, Lis T, Inglis R, et al. A family of [Mn(III)₆Ln(III)₂] rod-like clusters. Dalton Trans. 2015;44:6082-8 pubmed publisher
    ..reaction of Mn(ClO4)2·6H2O with H3L and the corresponding lanthanide nitrate in MeCN in the presence of a base, NEt3, yielded four complexes with the general formula [Mn(III)6Ln(III)2O2(OH)2(H2O)2(HL)6(NO3)6]·6MeCN·0...
  9. Yeh C, Kuo P, Wang Y, Wu Y, Chen M, Lin D, et al. SEPT12/SPAG4/LAMINB1 complexes are required for maintaining the integrity of the nuclear envelope in postmeiotic male germ cells. PLoS ONE. 2015;10:e0120722 pubmed publisher
    ..proteins (SEPT4 and SEPT6), nuclear or nuclear membrane proteins (protamine 2, sperm-associated antigen 4, and NDC1 transmembrane nucleoproine), and sperm-related structural proteins (pericentriolar material 1 and obscurin-like 1)...

More Information

Publications41

  1. Barroso S, Coelho A, Gómez Ruiz S, Calhorda M, Zižak Z, Kaluđerović G, et al. Synthesis, cytotoxic and hydrolytic studies of titanium complexes anchored by a tripodal diamine bis(phenolate) ligand. Dalton Trans. 2014;43:17422-33 pubmed publisher
    ..The reactions of [Ti((tBu2)O2NN')Cl]2(μ-O) (1) with LiO(I)Pr or HO(I)Pr in the presence of NEt3, aiming at the synthesis of the alkoxido derivative of 1 led to no reaction or to the synthesis of the monomeric ..
  2. Ma C, Zhang J, Li J, Cui C. Multiple C-H borylation of phenylhydrazones to boron-nitrogen analogues of benzopentalene. Chem Commun (Camb). 2015;51:5732-4 pubmed publisher
    ..a series of novel boron-nitrogen analogues of benzopentalene by the cleavage of C-H bonds with PhBBr2 mediated by NEt3 has been established...
  3. Zhang W, Neuner A, Rüthnick D, Sachsenheimer T, Lüchtenborg C, Brugger B, et al. Brr6 and Brl1 locate to nuclear pore complex assembly sites to promote their biogenesis. J Cell Biol. 2018;217:877-894 pubmed publisher
    ..This NPC biogenesis defect was not accompanied by a change in lipid composition. However, Brl1 interacted with Ndc1 and Nup188 by immunoprecipitation, and with transmembrane and outer and inner ring NPC components by split yellow ..
  4. Zhang M, Li D, He Y, Wang G. Preparation and photochromic properties of layer-by-layer self-assembly films and light-responsive micelles based on amphiphilic naphthopyran derivative. Spectrochim Acta A Mol Biomol Spectrosc. 2015;151:525-31 pubmed publisher
    ..light-responsive group to fabricate light-responsive micelles with polyethylene glycol-triethylamine bromide (PEG-NEt3)...
  5. Schmid B, Frieß S, Herrera A, Linden A, Heinemann F, Locke H, et al. Chiral amino-phosphine and amido-phosphine complexes of Ir and Mg. Catalytic applications in olefin hydroamination. Dalton Trans. 2016;45:12028-40 pubmed publisher
    ..of rac- and (S,S)-trans-9,10-dihydro-9,10-ethanoanthracene-11,12-diamine (ANDEN) with PClPh2 in the presence of NEt3 yield the chiral amino-phosphine ligands rac-6 and (S,S)-6, respectively, on multi-gram scales...
  6. Kupke T, Malsam J, Schiebel E. A ternary membrane protein complex anchors the spindle pole body in the nuclear envelope in budding yeast. J Biol Chem. 2017;292:8447-8458 pubmed publisher
    ..The SPB is built from 18 different proteins, including the three integral membrane proteins Mps3, Ndc1, and Mps2. These membrane proteins play an essential role in the insertion of the new SPB into the NE...
  7. Katta S, Chen J, Gardner J, Friederichs J, Smith S, Gogol M, et al. Sec66-Dependent Regulation of Yeast Spindle-Pole Body Duplication Through Pom152. Genetics. 2015;201:1479-95 pubmed publisher
    ..Cells lacking Sec66 have reduced levels of Pom152 protein but not Pom34 or Ndc1, a shared component of the NPC and SPB...
  8. Rüthnick D, Neuner A, Dietrich F, Kirrmaier D, Engel U, Knop M, et al. Characterization of spindle pole body duplication reveals a regulatory role for nuclear pore complexes. J Cell Biol. 2017;216:2425-2442 pubmed publisher
    ..After SPB insertion, membrane-associated proteins including the conserved Ndc1 encircle the SPB and retain it within the NE...
  9. Stavgianoudaki N, Siczek M, Lis T, Inglis R, Milios C. A triacontanuclear [Zn12Dy18] cluster: a ring of [Dy4] cubes. Chem Commun (Camb). 2016;52:343-5 pubmed publisher
    ..between Dy(NO3)3·6H2O, Zn(OAc)2·4H2O, salicylaldehyde and 2-amino-isobutyric acid, in MeOH in the presence of NEt3 under solvothermal conditions, led to the isolation of the triacontanuclear mixed-metal cluster [Zn(II)12Dy(III)18(..
  10. Liang W, Church T, Zheng S, Zhou C, Haynes B, D Alessandro D. Site Isolation Leads to Stable Photocatalytic Reduction of CO2 over a Rhenium-Based Catalyst. Chemistry. 2015;21:18576-9 pubmed publisher
    ..diimine)Re(CO)3Cl] moieties was produced and tested in the photocatalytic reduction of CO2, with NEt3 as a sacrificial donor...
  11. Overgaard J, Møller L, Borup M, Tricoire M, Walsh J, Diehl M, et al. Magnetism and variable temperature and pressure crystal structures of a linear oligonuclear cobalt bis-semiquinonate. Dalton Trans. 2016;45:12924-32 pubmed publisher
    The crystal structure of the first oligomeric cobalt dioxolene complex, Co3(3,5-DBSQ)2((t)BuCOO)4(NEt3)2, 1, where DBSQ is 3,5-di-tert-butyl-semiquinonate, has been studied at various temperatures between 20 and 200 K...
  12. Canaj A, Tzimopoulos D, Otręba M, Lis T, Inglis R, Milios C. Solvothermal synthesis of enneanuclear [Cu₇(II)Ln₂(III)] clusters. Dalton Trans. 2015;44:19880-5 pubmed publisher
    ..of Cu2(OAc)4·2H2O with H3L and the corresponding lanthanide nitrate salt in MeCN in the presence of a base, NEt3, yielded three complexes with the general formula [Cu₇(II)Ln₂(III)(L)4(HL)2(OAc)4]·2MeCN (Ln: Gd, ..
  13. Eguillor B, Esteruelas M, Lezáun V, Oliván M, Oñate E, Tsai J, et al. A Capped Octahedral MHC6 Compound of a Platinum Group Metal. Chemistry. 2016;22:9106-10 pubmed publisher
    ..obtained by reaction of OsH6 (PiPr3 )2 with N,N'-diphenylbenzimidazolium chloride ([Ph2 BImH]Cl) in the presence of NEt3 ...
  14. Witteman L, Evers T, Shu Z, Lutz M, Klein Gebbink R, Moret M. Hydrosilylation in Aryliminopyrrolide-Substituted Silanes. Chemistry. 2016;22:6087-99 pubmed publisher
    A range of silanes was synthesized by the reaction of HSiCl3 with iminopyrrole derivatives in the presence of NEt3 . In certain cases, intramolecular hydrosilylation converts the imine ligand into an amino substituent...
  15. Wang Y, Xie Y, Wei P, Schaefer H, Robinson G. Abnormal carbene-silicon halide complexes. Dalton Trans. 2016;45:5941-4 pubmed publisher
    ..Abnormal carbene-SiCl4 complex (8) may be conveniently synthesized by combining 7 with HCl·NEt3. In addition, 7 may react with CH2Cl2 in warm hexane, giving the abnormal carbene-complexed SiCl3(+) cation (9)...
  16. Mlateček M, Dostál L, Růžičková Z, Honzíček J, Holubová J, Erben M. The first scorpionate ligand based on diazaphosphole. Dalton Trans. 2015;44:20242-53 pubmed publisher
    The reaction of PhBCl2 with 1H-1,2,4-λ(3)-diazaphosphole in the presence of NEt3 gives a new scorpionate ligand, phenyl-tris(1,2,4-diazaphospholyl)borate (PhTdap)...
  17. Cao D, Hu J, Li M, Gong D, Li X, Ward M. Two bisthienylethene-Ir(III) complexes showing acid/base-induced structural transformation and on-off luminescence switching in solution. Dalton Trans. 2015;44:21008-15 pubmed publisher
    ..The structures of 1-H and 1 could be interconverted in solution, upon alternately adding NEt3 and TFA, thus resulting in reversible luminescence switching between the on-state of 1-H and the off-state of 1 at ..
  18. Curless L, Clark E, Cid J, Del Grosso A, Ingleson M. Complete reductive cleavage of CO facilitated by highly electrophilic borocations. Chem Commun (Camb). 2015;51:10903-6 pubmed publisher
    ..When R = Et, [(Et3N)H2B(μ-O)B(CH3)NEt3][B(C6F5)4], is isolated and demonstrated to be an intermediate in the formation of (MeBO)3.
  19. Suárez Suárez S, Carriedo G, Presa Soto A. Reversible Morphological Evolution of Responsive Giant Vesicles to Nanospheres by the Self-Assembly of Crystalline-b-Coil Polyphosphazene Block Copolymers. Chemistry. 2016;22:4483-91 pubmed publisher
    ..This morphological evolution is totally reversible by neutralization with a base (NEt3), which regenerates the original GUVs...
  20. Burns S, Avena J, Unruh J, Yu Z, Smith S, Slaughter B, et al. Structured illumination with particle averaging reveals novel roles for yeast centrosome components during duplication. elife. 2015;4: pubmed publisher
    ..Our observation that proteins involved in membrane insertion, such as Mps2, Bbp1, and Ndc1, also accumulate at the new SPB early in duplication suggests that SPB assembly and NE insertion are coupled events ..
  21. Casey A, Chen S, Novick P, Ferro Novick S, Wente S. Nuclear pore complex integrity requires Lnp1, a regulator of cortical endoplasmic reticulum. Mol Biol Cell. 2015;26:2833-44 pubmed publisher
    ..Furthermore, the essential NPC assembly factor Ndc1 has altered interactions in the absence of Sey1...
  22. Voitekhovich S, Grigoriev Y, Lyakhov A, Ivashkevich L, Ivashkevich O. The first organocopper tetrazole derivative: synthesis and characterization. Dalton Trans. 2016;45:13406-14 pubmed publisher
    ..The reaction of CuCl2, HL·2HCl and triethylamine (NEt3) in a molar ratio of 1?:?1?:?3 in water was found to generate a novel organometallic tetrazole derivative Cu2L2Cl2...
  23. Fatihi A, Latimer S, Schmollinger S, Block A, Dussault P, Vermaas W, et al. A Dedicated Type II NADPH Dehydrogenase Performs the Penultimate Step in the Biosynthesis of Vitamin K1 in Synechocystis and Arabidopsis. Plant Cell. 2015;27:1730-41 pubmed publisher
    Mutation of Arabidopsis thaliana NAD(P)H DEHYDROGENASE C1 (NDC1; At5g08740) results in the accumulation of demethylphylloquinone, a late biosynthetic intermediate of vitamin K1...
  24. Rossig C, Gray J, Valdés O, Rustgi S, von Wettstein D, Reinbothe C, et al. HP30-2, a mitochondrial PRAT protein for import of signal sequence-less precursor proteins in Arabidopsis thaliana. J Integr Plant Biol. 2017;59:535-551 pubmed publisher
    ..the inner membrane translocase TIM22 and the other containing an alternative NAD(P)H dehydrogenase subunit (NDC1) implicated in a respiratory complex 1-like electron transport chain...
  25. Stavru F, Hülsmann B, Spang A, Hartmann E, Cordes V, Gorlich D. NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes. J Cell Biol. 2006;173:509-19 pubmed
    ..Human NDC1 (hNDC1) likely possesses six transmembrane segments, and it is located at the nuclear pore wall...
  26. Kind B, Koehler K, Lorenz M, Huebner A. The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope. Biochem Biophys Res Commun. 2009;390:205-10 pubmed publisher
    ..Using a siRNA-based approach we downregulated the three known membrane integrated nucleoporins NDC1, GP210, and POM121 in stably expressing GFP-ALADIN HeLa cells...
  27. Mansfeld J, Güttinger S, Hawryluk Gara L, Pante N, Mall M, Galy V, et al. The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells. Mol Cell. 2006;22:93-103 pubmed
    ..In particular, almost nothing is known about how NPCs are anchored in the NE. Here, we characterize vertebrate NDC1--a transmembrane nucleoporin conserved between yeast and metazoans...
  28. Lau C, Delmar V, Forbes D. Topology of yeast Ndc1p: predictions for the human NDC1/NET3 homologue. Anat Rec A Discov Mol Cell Evol Biol. 2006;288:681-94 pubmed
    ..However, no homologues of Ndc1p had been characterized in metazoa. Here, we identify and analyze NDC1 homologues that are conserved throughout evolution...
  29. Yamazumi Y, Kamiya A, Nishida A, Nishihara A, Iemura S, Natsume T, et al. The transmembrane nucleoporin NDC1 is required for targeting of ALADIN to nuclear pore complexes. Biochem Biophys Res Commun. 2009;389:100-4 pubmed publisher
    b>NDC1 is a transmembrane nucleoporin that is required for NPC assembly and nucleocytoplasmic transport...
  30. Linder M, Köhler M, Boersema P, Weberruss M, Wandke C, Marino J, et al. Mitotic Disassembly of Nuclear Pore Complexes Involves CDK1- and PLK1-Mediated Phosphorylation of Key Interconnecting Nucleoporins. Dev Cell. 2017;43:141-156.e7 pubmed publisher
    ..Nup53 critically contributes to its liberation from its partner nucleoporins, including the pore membrane protein NDC1. Initial steps of NPC disassembly in semi-permeabilized cells can be reconstituted by a cocktail of mitotic kinases ..
  31. Lai T, Wu Y, Wang Y, Chen M, Wang P, Chen T, et al. SEPT12-NDC1 Complexes Are Required for Mammalian Spermiogenesis. Int J Mol Sci. 2016;17: pubmed
    ..membrane-related proteins have been identified as SEPT12 interactors through the yeast 2-hybrid system, including NDC1 transmembrane nucleoporin (NDC1)...
  32. Qiao W, Han Y, Jin W, Tian M, Chen P, Min J, et al. Overexpression and biological function of TMEM48 in non-small cell lung carcinoma. Tumour Biol. 2016;37:2575-86 pubmed publisher
    b>Transmembrane protein 48 (TMEM48), localized to nuclear pore complexes (NPCs), has been reported crucial for NPC assembly. Alterations in NPC members have been reported in several malignancies...