ND1

Summary

Gene Symbol: ND1
Description: NADH dehydrogenase, subunit 1 (complex I)
Alias: MTND1, NADH dehydrogenase, subunit 1 (complex I), NADH dehydrogenase subunit 1
Species: human
Products:     ND1

Top Publications

  1. Gibbs W, Weber R, Schnellmann R, Adkins D. Disrupted mitochondrial genes and inflammation following stroke. Life Sci. 2016;166:139-148 pubmed publisher
    ..The stroke-induced spatial and temporal profiles lay the foundation to target pharmacological therapeutics to these three pathways. ..
  2. Hoberg E, Makarikov A, Tkach V, Meagher S, Nims T, Eckerlin R, et al. Insights on the host associations and geographic distribution of Hymenolepis folkertsi (Cestoda: Hymenolepididae) among rodents across temperate latitudes of North America. Parasitol Res. 2016;115:4627-4638 pubmed
    ..folkertsi. Initial DNA sequence data, from a portion of the mitochondrial NADH dehydrogenase subunit 1, demonstrated intraspecific variation among three apparently geographically isolated populations ..
  3. Harmon J, Gibbs W, Whitaker R, Schnellmann R, Adkins D. Striatal Mitochondrial Disruption following Severe Traumatic Brain Injury. J Neurotrauma. 2017;34:487-494 pubmed publisher
    ..Additionally, expression of mitochondrial-encoded mRNAs, cytochrome c oxidase subunit 1 and NADH dehydrogenase subunit 1, was decreased at 3 and 6 days post-injury in ipsilesional striatum and at 6 days post-injury in ..
  4. Jesinkey S, Korrapati M, Rasbach K, Beeson C, Schnellmann R. Atomoxetine prevents dexamethasone-induced skeletal muscle atrophy in mice. J Pharmacol Exp Ther. 2014;351:663-73 pubmed publisher
    ..isoforms, ATP synthase β, cytochrome c oxidase subunit I, NADH dehydrogenase (ubiquinone) 1 β subcomplex, 8, ND1, insulin-like growth factor 1 (IGF-1), myostatin, muscle Ring-finger protein-1 (muscle atrophy), phosphorylated ..
  5. Tang C, Hou Y, Wang K, Xiang H, Wan X, Xia Y, et al. Aspartate ?-hydroxylase disrupts mitochondrial DNA stability and function in hepatocellular carcinoma. Oncogenesis. 2017;6:e362 pubmed publisher
    ..in HCC tissues was correlated with decreased copy numbers of displacement loop (D-loop) and NADH dehydrogenase subunit 1 (ND-1) and enhanced D-loop mutation, suggesting the disrupted mitochondrial DNA (mtDNA) stability...
  6. Roellig D, Savage M, Fujita A, Barnabé C, Tibayrenc M, Steurer F, et al. Genetic variation and exchange in Trypanosoma cruzi isolates from the United States. PLoS ONE. 2013;8:e56198 pubmed publisher
    ..synthase (DHFR-TS) and the cytochrome oxidase subunit II- NADH dehydrogenase subunit I region (COII-ND1), respectively...
  7. Zheng F, Liu H, Jiang M, Xu Z, Wang Z, Wang C, et al. The complete mitochondrial genome of the Caulerpa lentillifera (Ulvophyceae, Chlorophyta): Sequence, genome content, organization structure and phylogenetic consideration. Gene. 2018;673:225-238 pubmed publisher
    ..With the exception of the NADH dehydrogenase subunit 6 (ND6), ND1, ATP and three tRNA genes (tRNA-His, tRNA-Thr and tRNA-Ala), all other mitochondrial genes were encoded on the ..
  8. Sun Y, Kurisaki M, Hashiguchi Y, Kumazawa Y. Variation and evolution of polyadenylation profiles in sauropsid mitochondrial mRNAs as deduced from the high-throughput RNA sequencing. BMC Genomics. 2017;18:665 pubmed publisher
    ..In the last case of P. castaneus, as well as another example for NADH dehydrogenase subunit 1 mRNAs of some birds, the association between the polyadenylation site change and the gene overlap was ..
  9. Pecorella S, Potter J, Cherry A, Peacher D, Welty Wolf K, Moon R, et al. The HO-1/CO system regulates mitochondrial-capillary density relationships in human skeletal muscle. Am J Physiol Lung Cell Mol Physiol. 2015;309:L857-71 pubmed publisher
    ..A (Tfam), cytochrome c, cytochrome oxidase subunit IV (COX IV), and mitochondrial-encoded COX I and NADH dehydrogenase subunit 1 (NDI). CO breathing did not increase V̇o2max (1.96 ± 0.51 pre-CO, 1.87 ± 0...

More Information

Publications143 found, 100 shown here

  1. Im I, Jang M, Park S, Lee S, Choi J, Yoo H, et al. Mitochondrial Respiratory Defect Causes Dysfunctional Lactate Turnover via AMP-activated Protein Kinase Activation in Human-induced Pluripotent Stem Cell-derived Hepatocytes. J Biol Chem. 2015;290:29493-505 pubmed publisher
    ..3398T→C) in the mitochondrion-encoded NADH dehydrogenase 1 (MTND1) gene and that differentiated into hepatocytes (DMRC hepatocytes) in vitro...
  2. Bakke M, Agustí C, Bruusgaard J, Sundaram A, Horsberg T. Deltamethrin resistance in the salmon louse, Lepeophtheirus salmonis (Krøyer): Maternal inheritance and reduced apoptosis. Sci Rep. 2018;8:8450 pubmed publisher
    ..SNPs in two cytochrome C oxidase subunits (COX1 and COX3) and two subunits of the NADH dehydrogenase complex (ND1 and ND5) previously linked to DMT resistance in the salmon louse...
  3. Harmon J, Wills L, McOmish C, Demireva E, Gingrich J, Beeson C, et al. 5-HT2 Receptor Regulation of Mitochondrial Genes: Unexpected Pharmacological Effects of Agonists and Antagonists. J Pharmacol Exp Ther. 2016;357:1-9 pubmed publisher
    ..CP-809,101 and SB-242,084 increased mRNA expression of PGC-1α and the mitochondrial proteins NADH dehydrogenase subunit 1 and NADH dehydrogenase (ubiquinone) β subcomplex 8 in mice...
  4. Ahmed M, Salim B, Grobusch M, Aradaib I. First molecular characterization of Echinococcus granulosus (sensu stricto) genotype 1 among cattle in Sudan. BMC Vet Res. 2018;14:36 pubmed publisher
    ..and the germinal layer of each cyst and subsequently amplified by PCR targeting the mitochondrial NADH dehydrogenase subunit 1 (NADH-1) gene...
  5. Brunet J, Pesson B, Chermette R, Regnard P, Grimm F, Deplazes P, et al. First case of peritoneal cysticercosis in a non-human primate host (Macaca tonkeana) due to Taenia martis. Parasit Vectors. 2014;7:422 pubmed publisher
    ..PCR amplification and sequence analysis of the mitochondrial cytochrome c oxidase subunit 1 (cox1) and NADH dehydrogenase subunit 1 (nad1) genes. Exeresis of the lesion was not possible and praziquantel (5...
  6. Yang D, Zhang T, Zeng Z, Zhao W, Zhang W, Liu A. The first report of human-derived G10 genotype of Echinococcus canadensis in China and possible sources and routes of transmission. Parasitol Int. 2015;64:330-3 pubmed publisher
    ..canadensis based on mitochondrial cytochrome c oxidase subunit I (cox1), cytochrome b (cytb) and NADH dehydrogenase subunit 1 (nad1) genes. Homology analysis showed the cox1 gene sequence of G10 genotype of E...
  7. Radhakrishnan J, Bazarek S, Chandran B, Gazmuri R. Cyclophilin-D: a resident regulator of mitochondrial gene expression. FASEB J. 2015;29:2734-48 pubmed publisher
    ..e., NADH dehydrogenase 1 (ND1) by 11-fold, P < 0.005; cytochrome oxidase 1 (COX1) by 4-fold, P < 0...
  8. Oudni M rad M, M rad S, Ksia A, Lamiri R, Mekki M, Nouri A, et al. First molecular evidence of the simultaneous human infection with two species of Echinococcus granulosus sensu lato: Echinococcus granulosus sensu stricto and Echinococcus canadensis. Parasitol Res. 2016;115:1065-9 pubmed publisher
    ..Three targets, ribosomal DNA ITS1 fragment, NADH dehydrogenase subunit 1 (nad1), and mitochondrial cytochrome c oxydase subunit 1 (CO1) genes, were amplified and analyzed by ..
  9. Nikmanesh B, Mirhendi H, Mahmoudi S, Rokni M. Multilocus sequence analysis of Echinococcus granulosus strains isolated from humans and animals in Iran. Exp Parasitol. 2017;183:50-55 pubmed publisher
    ..e., cytochrome c oxidase subunit 1 (cox1), NADH dehydrogenase subunit 1 (nad1), ATPase subunit 6 (atp6), 12S rRNA (12S), and Actin II (act II)...
  10. Ichikawa Seki M, Ortiz P, Cabrera M, Hobán C, Itagaki T. Molecular characterization and phylogenetic analysis of Fasciola hepatica from Peru. Parasitol Int. 2016;65:171-4 pubmed publisher
    ..Eight haplotypes were obtained from the mitochondrial NADH dehydrogenase subunit 1 (nad1) sequences of Peruvian F...
  11. Ichikawa Seki M, Tokashiki M, Opara M, Iroh G, Hayashi K, Kumar U, et al. Molecular characterization and phylogenetic analysis of Fasciola gigantica from Nigeria. Parasitol Int. 2017;66:893-897 pubmed publisher
    ..gigantica on the basis of the concatenated sequence of mitochondrial NADH dehydrogenase subunit 1 (nad1) and cytochrome c oxidase 1 (cox1)...
  12. Hayashi K, Ichikawa Seki M, Allamanda P, Wibowo P, Mohanta U, Sodirun -, et al. Molecular characterization and phylogenetic analysis of Fasciola gigantica from western Java, Indonesia. Parasitol Int. 2016;65:424-7 pubmed publisher
    ..The flukes were then analyzed phylogenetically based on the nucleotide sequence of the mitochondrial NADH dehydrogenase subunit 1 (nad1) gene, together with Fasciola flukes from other Asian countries. All but one F...
  13. Debiaggi M, Soriano S, Pierangeli N, Lazzarini L, Pianciola L, Mazzeo M, et al. Genetic characterization of human hydatid cysts shows coinfection by Echinococcus canadensis G7 and Echinococcus granulosus sensu stricto G1 in Argentina. Parasitol Res. 2017;116:2599-2604 pubmed publisher
    ..5% of cases. Partial sequencing of mitochondrial cytochrome c oxidase subunit 1 (cox1) and NADH dehydrogenase subunit 1 (nad1) genes identified the presence of E. granulosus s.s. G1 (n = 11; 42...
  14. Li Z, Cheng T, Xu X, Song L, Liu G. Genetic variation in mitochondrial genes of the tick Haemaphysalis flava collected from wild hedgehogs in China. Exp Appl Acarol. 2017;71:131-137 pubmed publisher
    ..variation in three mitochondrial (mt) DNA regions, namely cytochrome c oxidase subunit 1 (cox1) and NADH dehydrogenase subunit 1 and 4 (nad1 and nad4), was examined in H. flava ticks collected from wild hedgehogs in China...
  15. Paoletti B, della Salda L, Di Cesare A, Iorio R, Vergara A, Fava C, et al. Epidemiological survey on cystic echinococcosis in wild boar from Central Italy. Parasitol Res. 2019;118:43-46 pubmed publisher
    ..characterized by analysis of the mitochondrial gene, cytochrome c oxidase subunit 1 (cox1), and the NADH dehydrogenase subunit 1 (ND1). Hydatids found in wild boars were characterized as E. granulosus sensu stricto (G1 genotype)...
  16. Mauti S, Traoré A, Crump L, Zinsstag J, Grimm F. First report of Echinococcus granulosus (genotype G6) in a dog in Bamako, Mali. Vet Parasitol. 2016;217:61-3 pubmed publisher
    ..Three microscopically positive fur samples were negative by PCR. Sequence analysis of part of the NADH dehydrogenase subunit 1 gene identified the parasite as E. granulosus (genotype G6; Echinococcus canadensis)...
  17. Malkamäki S, Näreaho A, Oksanen A, Sukura A. Berries as a potential transmission vehicle for taeniid eggs. Parasitol Int. 2019;70:58-63 pubmed publisher
    ..laticollis-specific primer pair amplifying a short fragment of mitochondrial NADH dehydrogenase subunit 1 gene. This indicates that forest berries contaminated in shrubs contained T...
  18. Ron S, Duellman W, Caminer M, Pazmino D. Advertisement calls and DNA sequences reveal a new species of Scinax (Anura: Hylidae) on the Pacific lowlands of Ecuador. PLoS ONE. 2018;13:e0203169 pubmed publisher
    ..based on mitochondrial DNA genes 12S rRNA, Cytochrome Oxidase sub-unit I, Cytochrome B, 16S rRNA, NADH dehydrogenase subunit 1, and adjacent tRNAs. The new species, Scinax tsachila sp. nov. was previously confused with S...
  19. Gómez Puerta L, Yucra D, López Urbina M, Gonzalez A. The alpaca (Vicugna pacos) as a natural intermediate host of Taenia omissa (Cestoda: Taeniidae). Vet Parasitol. 2017;246:93-95 pubmed publisher
    ..by PCR-based sequencing of mitochondrial genes of cytochrome c oxidase subunit 1 (cox1) and the NADH dehydrogenase subunit 1 (nad1)...
  20. Varcasia A, Sanna D, Casu M, Lahmar S, Dessì G, Pipia A, et al. Species delimitation based on mtDNA genes suggests the occurrence of new species of Mesocestoides in the Mediterranean region. Parasit Vectors. 2018;11:619 pubmed publisher
    ..The genes cytochrome c oxidase subunit 1 (cox1) and NADH dehydrogenase subunit 1 (nad1) of the mitochondrial genome were used as molecular markers to investigate the presence of ..
  21. Xie K, Zhu M, Xiang P, Chen X, Kasimumali A, Lu R, et al. Protein Kinase A/CREB Signaling Prevents Adriamycin-Induced Podocyte Apoptosis via Upregulation of Mitochondrial Respiratory Chain Complexes. Mol Cell Biol. 2018;38: pubmed publisher
    ..Inhibition of CREB expression alleviated pCPT-cAMP-induced ND3, but not the recovery of ND1/4 protein, in ADR-treated podocytes...
  22. PavÓn vÁzquez C, García Vázquez U, Bryson R, Fería Ortíz M, Manríquez Morán N, de Oca A. Integrative species delimitation in practice: Revealing cryptic lineages within the short-nosed skink Plestiodon brevirostris (Squamata: Scincidae). Mol Phylogenet Evol. 2018;129:242-257 pubmed publisher
    ..The mitochondrial fragment includes the full length of the gene coding for the NADH dehydrogenase subunit 1 protein, a segment of the gene coding for 16S ribosomal RNA, and flanking tRNAs...
  23. Sun D, Li B, Qiu R, Fang H, Lyu J. Cell Type-Specific Modulation of Respiratory Chain Supercomplex Organization. Int J Mol Sci. 2016;17: pubmed publisher
    ..In addition, we observed that the 3697G>A mutation in mitochondrial-encoded NADH dehydrogenase 1 (ND1) in one patient with Leigh's disease specifically affected the assembly of supercomplex In + IIIn + IVn containing ..
  24. Ichikawa Seki M, Shiroma T, Kariya T, Nakao R, Ohari Y, Hayashi K, et al. Molecular characterization of Fasciola flukes obtained from wild sika deer and domestic cattle in Hokkaido, Japan. Parasitol Int. 2017;66:519-521 pubmed publisher
    ..However, almost all the flukes had Fsp1 haplotype in NADH dehydrogenase subunit 1 (nad1) gene, indicating that their maternal lineage was F. hepatica...
  25. Li W, Qi Y, Cui X, Sun Y, Huo Q, Yang Y, et al. Heteroplasmy and Copy Number Variations of Mitochondria in 88 Hepatocellular Carcinoma Individuals. J Cancer. 2017;8:4011-4017 pubmed publisher
    ..Worthwhile mention, ND1 gene harbored greater mutation frequency and more nonsynonymous mutations in tumor samples...
  26. Hayashi K, Ichikawa Seki M, Mohanta U, Shoriki T, Chaichanasak P, Itagaki T. Hybrid origin of Asian aspermic Fasciola flukes is confirmed by analyzing two single-copy genes, pepck and pold. J Vet Med Sci. 2017;: pubmed publisher
    ..The results were compared with their mitochondrial NADH dehydrogenase subunit 1 (nad1) lineages for obtaining a definitive evidence of the hybrid origin of aspermic Fasciola flukes...
  27. Liang Q, Zeng J, Wu J, Qiao L, Chen Q, Chen D, et al. Nucleoside reverse transcriptase inhibitors induced hepatocellular mitochondrial DNA lesions and compensatory enhancement of mitochondrial function and DNA repair. Int J Antimicrob Agents. 2018;51:385-392 pubmed publisher
    ..The captured hepatocytes had greater diversity in their mtDNA D-loop, dehydrogenase subunit1 (ND1) and ND4 than the controls...
  28. Cui X, Wang J, Liu K, Cui S, Zhang J, Luo Y, et al. Role of heteroplasmic mutations in the mitochondrial genome and the ID4 gene promoter methylation region in the pathogenesis of chronic aplastic anemia in patients suffering from Kidney yin deficiency. Chin J Integr Med. 2016;22:412-9 pubmed publisher
    ..Higher mutational rates were observed in the ND1-2, ND4-6, and CYTB genes in CAA patients suffering from Kidney yin deficiency...
  29. Astuya A, Carrera C, Ulloa V, Aballay A, Núñez Acuña G, Hégaret H, et al. Saxitoxin Modulates Immunological Parameters and Gene Transcription in Mytilus chilensis Hemocytes. Int J Mol Sci. 2015;16:15235-50 pubmed publisher
    ..levels of genes encoding for antioxidant enzymes (SOD, CAT), mitochondrial enzymes (COI, COIII, CYTB, ATP6, ND1) and ion channels (K+, Ca2+)...
  30. Zeng R, Fang Y, Zhang Y, Bai S. p62 is linked to mitophagy in oleic acid-induced adipogenesis in human adipose-derived stromal cells. Lipids Health Dis. 2018;17:133 pubmed publisher
    ..Moreover, the copy number of mtDNA (the ND1 gene) and the protein level of TOM20, a mitochondrial membrane protein, were increased following OA treatment, ..
  31. Garcia Esparcia P, Koneti A, Rodríguez Oroz M, Gago B, del Río J, Ferrer I. Mitochondrial activity in the frontal cortex area 8 and angular gyrus in Parkinson's disease and Parkinson's disease with dementia. Brain Pathol. 2018;28:43-57 pubmed publisher
    ..Moreover, expression of MT-ND1 which is encoded by mitochondrial DNA is also reduced in PDD...
  32. Zhang Y, He Y, Yu H, Ma F, Wu J, Zhang X. Liquiritigenin Protects Rats from Carbon Tetrachloride Induced Hepatic Injury through PGC-1α Pathway. Evid Based Complement Alternat Med. 2015;2015:649568 pubmed publisher
    ..oxidative stress, elevated expression of inflammation and fibrotic genes, and downregulation of PGC-1α, ND1, and Bcl-x in rat liver. All these changes were abolished or alleviated by lliquiritigenin...
  33. Czapski G, Cieslik M, Wencel P, Wójtowicz S, Strosznajder R, Strosznajder J. Inhibition of poly(ADP-ribose) polymerase-1 alters expression of mitochondria-related genes in PC12 cells: relevance to mitochondrial homeostasis in neurodegenerative disorders. Biochim Biophys Acta Mol Cell Res. 2018;1865:281-288 pubmed publisher
    ..genes regulating mitochondrial fission/fusion (Mfn1, Mfn2, Dnm1l, Opa1, Fis1), subunits of ETC complexes (mt-Nd1, Sdha, mt-Cytb) and modulated expression of several TFs, enhanced Foxo1 and decreased Nrf1, Stat6, Nfkb1...
  34. Wei Y, Cui L, Peng B. Mitochondrial DNA mutations in late-onset Leigh syndrome. J Neurol. 2018;265:2388-2395 pubmed publisher
    ..In order of frequency, they were MT-ND3 (7/16), ND5 (3/16), ND6 (2/16), and ND1 (1/16)...
  35. Giulivi C, Zhang Y, Omanska Klusek A, Ross Inta C, Wong S, Hertz Picciotto I, et al. Mitochondrial dysfunction in autism. JAMA. 2010;304:2389-96 pubmed publisher
    ..Deletions at the segment of cytochrome b were observed in 2 cases (ratio of cytochrome b to ND1: 0.80 [95% CI, 0.68-0.92] vs 0.99 [95% CI, 0.93-1.05] for controls; P = .01)...
  36. Bijak M, Synowiec E, Sitarek P, Sliwinski T, Saluk Bijak J. Evaluation of the Cytotoxicity and Genotoxicity of Flavonolignans in Different Cellular Models. Nutrients. 2017;9: pubmed publisher
    ..of spontaneous mitochondrial DNA (mtDNA) damage in A549, measured as mtDNA copies, and mtDNA lesions in ND1 and ND5 genes...
  37. Magalhães Gomes M, Motta Santos D, Schetino L, Andrade J, Bastos C, Guimarães D, et al. Fast and slow-twitching muscles are differentially affected by reduced cholinergic transmission in mice deficient for VAChT: A mouse model for congenital myasthenia. Neurochem Int. 2018;120:1-12 pubmed publisher
    ..exhibit altered levels of markers for myogenesis (Pax-7, Myogenin, and MyoD), oxidative metabolism (PGC1-α and MTND1), and protein degradation (Atrogin1 and MuRF1) in VAChT-KDHOM mice...
  38. Liu S, Li X, Zhang S, Yang Z, Wang K, Lu F, et al. Acanthopanax senticosus Protects Structure and Function of Mesencephalic Mitochondria in A Mouse Model of Parkinson's Disease. Chin J Integr Med. 2018;24:835-843 pubmed publisher
    ..ubiquinone flavoprotein 2 (NDUFV2), mitochondrially encoded nicotinamide adenine dinucleotide dehydrogenase 1 (MT-ND1), succinate dehydrogenase complex subunit A (SDHA), and succinate dehydrogenase cytochrome b560 subunit (SDHC)...
  39. Yang R, Guan D, Xu S. Complete mitochondrial genome of the Chinese endemic grasshopper Fruhstorferiola kulinga (Orthoptera: Acrididae: Podismini). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:3240-1 pubmed publisher
    ..Most of the PCGs use TAA as their stop codons, while the others use TAG as stop codons (COX1 and ND1). The size of the large and small ribosomal RNA genes are 1314 bp and 851 bp...
  40. Bonnet C, Augustin S, Ellouze S, Benit P, Bouaita A, Rustin P, et al. The optimized allotopic expression of ND1 or ND4 genes restores respiratory chain complex I activity in fibroblasts harboring mutations in these genes. Biochim Biophys Acta. 2008;1783:1707-17 pubmed publisher
    ..of complex I activity in cultured skin fibroblasts isolated from two LHON patients harboring mutations in ND4 or ND1 genes...
  41. Covarrubias D, Bai R, Wong L, Leal S. Mitochondrial DNA variant interactions modify breast cancer risk. J Hum Genet. 2008;53:924-8 pubmed publisher
  42. Webb E, Broderick P, Chandler I, Lubbe S, Penegar S, Tomlinson I, et al. Comprehensive analysis of common mitochondrial DNA variants and colorectal cancer risk. Br J Cancer. 2008;99:2088-93 pubmed publisher
    ..In conclusion, our results provide little evidence that mitochondrial genetic background plays a role in modifying an individual's risk of developing CRC. ..
  43. Liu P, Zhu D, Zhao W, Ji X. The complete mitochondrial genome of the common lizard Zootoca vivipara (Squamata: Lacertidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:1944-5 pubmed publisher
    ..95%, C: 24.03%, A: 32.48%, G: 12.54%). Protein-coding genes begin with ATG as start codon except COII with GTG. ND1, ATP8, ATP6, ND4L, ND5 and Cyt b genes are terminated with TAA as stop codon, ND2 ends with TAG, COI and ND6 end ..
  44. Sharma D, Sunkaria A, Wani W, Sharma R, Verma D, Priyanka K, et al. Quercetin protects against aluminium induced oxidative stress and promotes mitochondrial biogenesis via activation of the PGC-1α signaling pathway. Neurotoxicology. 2015;51:116-37 pubmed publisher
    ..Besides this an increase in the mRNA levels of the mitochondrial encoded subunits - ND1, ND2, ND3, Cyt b, COX1, COX3 and ATPase6 along with increased expression of nuclear encoded subunits COX4, COX5A ..
  45. Khorsandi S, Taanman J, Heaton N. Subunit composition of respiratory chain complex 1 and its responses to oxygen in mitochondria from human donor livers. BMC Res Notes. 2017;10:547 pubmed publisher
    ..Membranes were probed with antibodies against β-actin and the following subunits of Complex 1: MTND1, NDUFA10, NDUFB6 and NDUFV2...
  46. Wang Y, Guo X, Jia X, Li S, Xiao X, Guo L, et al. [Clinical features and the mutation of Leber's hereditary optic neuropathy in Chinese patients]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22:334-6 pubmed
    ..The clinical features are associated with the site of primary mutation. The visual acuity at onset of the disease and the visual recovery of the eyes with 14484C mutation were better than the eyes with the 11778A mutation. ..
  47. Moslemi A, Darin N, Tulinius M, Wiklund L, Holme E, Oldfors A. Progressive encephalopathy and complex I deficiency associated with mutations in MTND1. Neuropediatrics. 2008;39:24-8 pubmed publisher
    ..Sequencing analysis of mitochondrial encoded ND genes (MTND) showed two DE NOVO mutations in MTND1 in both patients. Patient 1 had a novel heteroplasmic G3890A mutation, R195Q...
  48. Zhang P, Fang H, Pan W, Pan H. The complete mitochondrial genome of Chinese pond mussel Sinanodonta woodiana (Unionoida: Unionidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:1620-1 pubmed publisher
    ..8%). F ORF (Female-specific open reading frame) begins with ATA, Cyt b begins with ATC, ATP6, ATP8, COII, COIII, ND1, ND2, ND3 and ND5 begin with ATG, ND4L begins with GTG, COI begins with TTG, and other two protein-coding genes ..
  49. Mahami Oskouei M, Kaseb Yazdanparast A, Spotin A, Shahbazi A, Adibpour M, Ahmadpour E, et al. Gene flow for Echinococcus granulosus metapopulations determined by mitochondrial sequences: A reliable approach for reflecting epidemiological drift of parasite among neighboring countries. Exp Parasitol. 2016;171:77-83 pubmed publisher
    ..DNA samples were extracted, amplified and subjected to sequence analysis of NADH dehydrogenase subunit 1 (nad1) and cytochrome oxidase subunit 1 (cox1) genes...
  50. Muñoz San Martín C, Apt W, Zulantay I. Real-time PCR strategy for the identification of Trypanosoma cruzi discrete typing units directly in chronically infected human blood. Infect Genet Evol. 2017;49:300-308 pubmed publisher
    ..Two nuclear (SL-IR and 18S rDNA) and two mitochondrial genes (COII and ND1) were selected to develop original primers. The method was evaluated with eight genomic DNA of T...
  51. Yang J, Zhu Y, Chen L, Zhang H, Tong Y, Huang D, et al. Novel A14841G mutation is associated with high penetrance of LHON/C4171A family. Biochem Biophys Res Commun. 2009;386:693-6 pubmed publisher
    We report the clinical and genetic characterization of a Chinese LHON family carrying an ND1/C4171A mutation...
  52. Wang Z, Li C, Fang W, Yu X. The complete mitochondrial genome of the wolf spider Wadicosa fidelis (Araneae: Lycosidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:3909-3910 pubmed
    ..The usual termination codons (TAA and TAG) are found from nine PCGs. However, COI, ND1, ND4L, ND5 had an incomplete termination codon (T). The control region (D-loop) is 1071 bp long with 67...
  53. Huang J, Su Y, Zhao J, Liu X, Wang Z. The complete mitogenome sequence of Pseudohynobius jinfo (Urodela: Hynobiidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:3141-2 pubmed publisher
    ..The gene order and composition of P. jinfo was similar to that of the most Hynobiidae. Seven genes (ND1, ND2, COII, COIII, ND3, ND4 and Cytb) had an incomplete stop codon. Base composition of the genome was A (33...
  54. Munakata K, Tanaka M, Mori K, Washizuka S, Yoneda M, Tajima O, et al. Mitochondrial DNA 3644T-->C mutation associated with bipolar disorder. Genomics. 2004;84:1041-50 pubmed
    ..The result of modest functional impairment caused by 3644T-->C suggests that this mutation could increase the risk for bipolar disorder. ..
  55. Liu S, Zhou X, Zheng F, Li X, Qin H, Zhang H, et al. [Development of a DNA chip screening mitochondrial DNA mutations in patients with diabetes mellitus]. Zhonghua Yi Xue Za Zhi. 2006;86:2853-7 pubmed
    ..high-throughput mitochondrial (mt) DNA chip and to investigate the relationship between mtDNA tRNA Leu (UUR) and ND1 gene mutations and diabetes mellitus...
  56. Delmiro A, Rivera H, Garcia Silva M, Garcia Consuegra I, Martin Hernandez E, Quijada Fraile P, et al. Whole-exome sequencing identifies a variant of the mitochondrial MT-ND1 gene associated with epileptic encephalopathy: west syndrome evolving to Lennox-Gastaut syndrome. Hum Mutat. 2013;34:1623-7 pubmed publisher
    ..was possible to obtain whole mitochondrial DNA sequencing and to identify a heteroplasmic variant in the MT-ND1 (MTND1) gene (m.3946G>A, p.E214K)...
  57. Yamaji T, Ishikawa T, Nomura M. Intraspecific Variation of Eysarcoris guttigerus (Hemiptera: Pentatomidae) in Japanese Southwest Population Based on Mitochondrial DNA. J Insect Sci. 2016;16: pubmed publisher
    ..subunit 2 (ND2), cytochrome oxidase subunit 1 (CO1), cytochrome b (Cytb), tRNA-Serine (tRNA(ser)), NADH dehydrogenase subunit 1 (ND1), and 16S ribosomal RNA (16SrRNA) genes from 13 populations of Japan...
  58. Lindqvist C, Roy T, Lydersen C, Kovacs K, Aars J, Wiig Ã, et al. Genetic diversity of historical Atlantic walruses (Odobenus rosmarus rosmarus) from Bjørnøya and Håøya (Tusenøyane), Svalbard, Norway. BMC Res Notes. 2016;9:112 pubmed publisher
    ..Using ancient DNA methodologies, the mitochondrial NADH dehydrogenase 1 (ND1) gene, the cytochrome c oxidase 1 (COI) gene, and the control region (CR) were targeted for 15 specimens from Bjø..
  59. Prakash C, Kumar V. Chronic Arsenic Exposure-Induced Oxidative Stress is Mediated by Decreased Mitochondrial Biogenesis in Rat Liver. Biol Trace Elem Res. 2016;173:87-95 pubmed publisher
    ..The messenger RNA (mRNA) expression of mitochondrial and nuclear-encoded subunits of complexes I (ND1 and ND2) and IV (COX I and COX IV) was downregulated in arsenic-treated rats only...
  60. Wu Y, Li L, Zhu G, Li W, Zhang N, Li S, et al. Mitochondrial genome data confirm that yaks can serve as the intermediate host of Echinococcus canadensis (G10) on the Tibetan Plateau. Parasit Vectors. 2018;11:166 pubmed publisher
    ..Full-length mitochondrial (mt) cytochrome c oxidase subunit 1 (cox1) and NADH dehydrogenase subunit 1 (nad1) genes were amplified by PCR...
  61. Liu Y, Li Z, Yang L, Wang S, Guan M. The mitochondrial ND1 T3308C mutation in a Chinese family with the secondary hypertension. Biochem Biophys Res Commun. 2008;368:18-22 pubmed publisher
    ..of the complete mitochondrial DNA in this pedigree revealed the presence of the known hypertension-associated ND1 T3308C mutation and 42 other variants, belonging to the Asian haplogroup D4h...
  62. Jackman M, Ravussin E, Rowe M, Pratley R, Milner M, Willis W. Effect of a polymorphism in the ND1 mitochondrial gene on human skeletal muscle mitochondrial function. Obesity (Silver Spring). 2008;16:363-8 pubmed publisher
    A non-silent polymorphism in the mitochondrial coding region of the ND1 gene, a subunit of reduced nicotinamide adenine dinucleotide (NADH) dehydrogenase is associated with resting metabolic rate (RMR) in 245 non-diabetic Pima Indians...
  63. Shrem T, Deouell L. Hierarchies of Attention and Experimental Designs: Effects of Spatial and Intermodal Attention Revisited. J Cogn Neurosci. 2017;29:203-219 pubmed
    ..Whether spatial attention was transient or sustained did not alter the effect of spatial attention on visual N1 and Nd1 responses...
  64. Xu L, Hu Y, Chen B, Tang W, Han X, Yu H, et al. Mitochondrial polymorphisms as risk factors for endometrial cancer in southwest China. Int J Gynecol Cancer. 2006;16:1661-7 pubmed
    ..two hypervariable segments of control region, part of 16sRNA gene, tRNA(leu) (tRNA is transfer RNA) gene and ND1 gene of mtDNA and identified some diagnostic polymorphisms by restriction fragment length polymorphism of coding ..
  65. Fraija Fernández N, Fernandez M, Lehnert K, Raga J, Siebert U, Aznar F. Long-Distance Travellers: Phylogeography of a Generalist Parasite, Pholeter gastrophilus, from Cetaceans. PLoS ONE. 2017;12:e0170184 pubmed publisher
    ..The ITS2 rDNA, and the mitochondrial COI and ND1 from 68 individual parasites were analysed...
  66. Ishii J, Sato H, Sakaeda M, Shishido Hara Y, Hiramatsu C, Kamma H, et al. POU domain transcription factor BRN2 is crucial for expression of ASCL1, ND1 and neuroendocrine marker molecules and cell growth in small cell lung cancer. Pathol Int. 2013;63:158-68 pubmed publisher
    ..in the expression of the lineage-specific transcription factors (achaete-scute homolog-like 1 (ASCL1) and NeuroD1 (ND1)) and neural/neuroendocrine marker molecules (neural cell adhesion molecule 1 (NCAM1), synaptophysin (SYP) and ..
  67. Peng X, Zhou P, Qiang Y, Qian Z. Characterization of the complete mitochondrial genome of Bombyx huttoni (Lepidoptera: Bombycidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:4112-4113 pubmed
    ..Twelve PCGs (COX2, COX3, CYTB, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, ATP6, and ATP) are initiated with the typical ATN codons, whereas COX1 was ..
  68. Ji Y, Liang M, Zhang J, Zhu L, Zhang Z, Fu R, et al. Mitochondrial ND1 Variants in 1281 Chinese Subjects With Leber's Hereditary Optic Neuropathy. Invest Ophthalmol Vis Sci. 2016;57:2377-89 pubmed publisher
    The purpose of this study was to investigate the mutational incidence and spectrum of mitochondrial ND1 gene in subjects with Leber's hereditary optic neuropathy (LHON)...
  69. Pham H, Hoang M, Ha T, Dang L, Tran V, Nguyen T, et al. Discrimination of different geographic varieties of Gymnema sylvestre, an anti-sweet plant used for the treatment of type 2 diabetes. Phytochemistry. 2018;150:12-22 pubmed publisher
    ..variety led to the isolation of four known compounds and nine previously undescribed compounds, named gymnemosides ND1-ND9. None of the isolated compounds were reported in the Indian sample, further supporting the geo-diversity of G...
  70. Inagaki Y, Mashima Y, Fuse N, Ohtake Y, Fujimaki T, Fukuchi T. Mitochondrial DNA mutations with Leber's hereditary optic neuropathy in Japanese patients with open-angle glaucoma. Jpn J Ophthalmol. 2006;50:128-34 pubmed
    ..Rare LHON-associated mitochondrial DNA mutations were found in Japanese patients with open-angle glaucoma (OAG). However, whether mitochondrial DNA mutations are risk factors for OAG is still open to question. ..
  71. Swerdlow R, Weaver B, Grawey A, Wenger C, Freed E, Worrall B. Complex I polymorphisms, bigenomic heterogeneity, and family history in Virginians with Parkinson's disease. J Neurol Sci. 2006;247:224-30 pubmed
    ..I-relevant gene polymorphisms alternatively reported to associate and not associate with PD (tRNA(Gln) T4336C, ND1 T4216C, ND2 G5460A, and the NDUFV2 exon 2 C182T transition)...
  72. Nan X, Wei C, He H. The complete mitogenome of Eucryptorrhynchus brandti (Harold) (Insecta: Coleoptera: Curculionidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:2060-1 pubmed publisher
    ..GU176342) and Naupactus xanthographus (GU176345). All PCGs initiated with ATN codons, except for the ND1 started with TTG. Two PCGs (COI and ND4) have an incomplete stop codon T...
  73. Kikuchi T, Afrin T, Yoshida M. Complete mitochondrial genomes of four entomopathogenic nematode species of the genus Steinernema. Parasit Vectors. 2016;9:430 pubmed publisher
    ..05-76.76 %). All the expected genes, including 12 protein-coding genes (encoding ATP6, CYTB, COX1-3, ND1-6 and ND4L), two rRNA genes and 22 tRNA genes were identified in the four genomes...
  74. Ushiki N, Jinno M, Fujitani H, Suenaga T, Terada A, Tsuneda S. Nitrite oxidation kinetics of two Nitrospira strains: The quest for competition and ecological niche differentiation. J Biosci Bioeng. 2017;123:581-589 pubmed publisher
    ..strain ND1 and Nitrospira japonica strain NJ1, which were previously isolated from activated sludge in a WWTP...
  75. Wang Y, Cao J, Li W. Complete Mitochondrial Genome of Suwallia teleckojensis (Plecoptera: Chloroperlidae) and Implications for the Higher Phylogeny of Stoneflies. Int J Mol Sci. 2018;19: pubmed publisher
    ..Most PCGs initiate with the standard start codon ATN. However, ND5 and ND1 started with GTG and TTG...
  76. Richter G, Sonnenschein A, Grunewald T, Reichmann H, Janetzky B. Novel mitochondrial DNA mutations in Parkinson's disease. J Neural Transm (Vienna). 2002;109:721-9 pubmed
    ..As complex I genes are the most vulnerable part of mtDNA we analyzed the mitochondrial MTND1 and MTND2 genes of 10 substantia nigra and 85 platelet samples from PD patients...
  77. Zhang Y, Xu J, Zhang M, Han S. [Mitochondrial DNA coding region 3954-4506 polymorphism in Korean Chinese population]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009;26:106-8 pubmed publisher
  78. Simon D, Friedman J, Breakefield X, Jankovic J, Brin M, Provias J, et al. A heteroplasmic mitochondrial complex I gene mutation in adult-onset dystonia. Neurogenetics. 2003;4:199-205 pubmed
    ..heteroplasmic missense A to G base pair substitution at nucleotide position 3796 (A3796G) in the gene encoding the ND1 subunit of mitochondrial complex I in a patient with adult-onset dystonia, spasticity, and core-type myopathy...
  79. Houshmand M, Sanati M, Rashedi I, Sharifpanah F, Asghari E, Lotfi J. Lack of association between Leber's hereditary optic neuropathy primary point mutations and multiple sclerosis in Iran. Eur Neurol. 2004;51:68-71 pubmed
    ..Our results suggest that there is no association between Iranian patients with MS and mtDNA point mutations at np 11,778, 3,460, and 14,484. ..
  80. Autere J, Moilanen J, Finnila S, Soininen H, Mannermaa A, Hartikainen P, et al. Mitochondrial DNA polymorphisms as risk factors for Parkinson's disease and Parkinson's disease dementia. Hum Genet. 2004;115:29-35 pubmed
    ..Our results suggest that a relative excess of nonsynonymous mutations in MTND genes in supercluster JTWIX is associated with an increased risk of PD and the disease progression to dementia. ..
  81. Guo L, Oshida Y, Fuku N, Takeyasu T, Fujita Y, Kurata M, et al. Mitochondrial genome polymorphisms associated with type-2 diabetes or obesity. Mitochondrion. 2005;5:15-33 pubmed
    ..Two mtSNPs, 3497C > T (A64V) in NADH dehydrogenase subunit 1 gene (ND1) and 1119T > C (472U > C) in the 12S rRNA gene, were detected in 5 of the 96 young ..
  82. Arnestad M, Opdal S, Vege A, Rognum T. A mitochondrial DNA polymorphism associated with cardiac arrhythmia investigated in sudden infant death syndrome. Acta Paediatr. 2007;96:206-10 pubmed
    ..The mtDNA polymorphism studied was found in a small number of SIDS cases and the frequency did not differ statistically from control subjects, making an association with increased SIDS risk unlikely. ..
  83. Hinttala R, Kervinen M, Uusimaa J, Maliniemi P, Finnila S, Rantala H, et al. Analysis of functional consequences of haplogroup J polymorphisms m.4216T>C and m.3866T>C in human MT-ND1: mutagenesis of homologous positions in Escherichia coli. Mitochondrion. 2010;10:358-61 pubmed publisher
    ..4216T>C present in haplogroup J. Furthermore, we evaluated m.3866T>C in MT-ND1, a variant detected in a child belonging to haplogroup J and with an isolated complex I deficiency...
  84. Andalib S, Emamhadi M, Yousefzadeh Chabok S, Salari A, Sigaroudi A, Vafaee M. MtDNA T4216C variation in multiple sclerosis: a systematic review and meta-analysis. Acta Neurol Belg. 2016;116:439-443 pubmed
    ..38, 95 % CI = 1.13-1.67, P = 0.001). The present systematic review and meta-analysis suggest that mtDNA T4216C variation is a contributory factor in susceptibility to MS. ..
  85. Soldath P, Wegener M, Sander B, Rosenberg T, Duno M, Wibrand F, et al. Leber hereditary optic neuropathy due to a new ND1 mutation. Ophthalmic Genet. 2017;38:480-485 pubmed publisher
    ..3,395A>G mutation in the ND1 gene...
  86. Rouhani S, Raeghi S, Spotin A. Spermatogenic and Phylo-molecular Characterizations of Isolated Fasciola Spp. From Cattle, North West Iran. Pak J Biol Sci. 2017;20:204-209 pubmed publisher
    ..hepatica and F. gigantica by using nuclear and mitochondrial markers (ITS1, ND1 and CO1) and have been employed to analyze intraspecific phylogenetic relations of Fasciola spp.
  87. Gazestani V, Hampton M, Shaw A, Salavati R, Zimmer S. Tail characteristics of Trypanosoma brucei mitochondrial transcripts are developmentally altered in a transcript-specific manner. Int J Parasitol. 2018;48:179-189 pubmed publisher
    ..to which tail characteristics differ among cytochrome c oxidase subunits I and III (CO1 and CO3), and NADH dehydrogenase subunit 1 (ND1) transcripts, and to what extent these characteristics differ developmentally...
  88. Velez D, Menon R, Simhan H, Fortunato S, Canter J, Williams S. Mitochondrial DNA variant A4917G, smoking and spontaneous preterm birth. Mitochondrion. 2008;8:130-5 pubmed
    ..Our data, although preliminary, support the hypothesis that mitochondrial genome polymorphisms may play a significant role in PTB through an interaction with smoking. ..
  89. Zhang L, Adyshev D, Singleton P, Li H, Cepeda J, Huang S, et al. Interactions between PBEF and oxidative stress proteins--a potential new mechanism underlying PBEF in the pathogenesis of acute lung injury. FEBS Lett. 2008;582:1802-8 pubmed publisher
    ..The interactions between PBEF and NADH dehydrogenase subunit 1(ND1), ferritin light chain and interferon induced transmembrane 3 (IFITM3) in human pulmonary vascular ..
  90. Zou Y, Jia X, Zhang A, Wang W, Li S, Guo X, et al. The MT-ND1 and MT-ND5 genes are mutational hotspots for Chinese families with clinical features of LHON but lacking the three primary mutations. Biochem Biophys Res Commun. 2010;399:179-85 pubmed publisher
    ..Eight of 12 private non-synonymous variants in the probands are located in the MT-ND1 and MT-ND5 genes, which is substantially higher than that of individuals from general Chinese populations...
  91. Lin J, Zhao C, Lu J, Wang H, Zhu W, Xi J, et al. Novel mutations m.3959G>A and m.3995A>G in mitochondrial gene MT-ND1 associated with MELAS. Mitochondrial DNA. 2014;25:56-62 pubmed publisher
    ..Sequencing of the mitochondrial DNA revealed two novel MT-ND1 gene missense mutations, m.3959G>A and m.3995A>G, which are highly conserved among species...
  92. Uddin A, Choudhury M, Chakraborty S. Codon usage bias and phylogenetic analysis of mitochondrial ND1 gene in pisces, aves, and mammals. Mitochondrial DNA A DNA Mapp Seq Anal. 2018;29:36-48 pubmed publisher
    The mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 (MT-ND1) gene is a subunit of the respiratory chain complex I and involved in the first step of the electron transport chain of oxidative phosphorylation (OXPHOS)...