NCR3

Summary

Gene Symbol: NCR3
Description: natural cytotoxicity triggering receptor 3
Alias: 1C7, CD337, LY117, MALS, NKp30, NK-p30, activating NK-A1 receptor, activating natural killer receptor p30, lymphocyte antigen 117, natural killer cell p30-related protein
Species: human

Top Publications

  1. ncbi Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells
    Elke Pogge von Strandmann
    Department of Internal Medicine I, University Hospital of Cologne, Kerpener Str 62, D 50924 Cologne, Germany
    Immunity 27:965-74. 2007
  2. ncbi Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Blood 107:2030-6. 2006
  3. pmc Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells
    D Pende
    Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
    J Exp Med 190:1505-16. 1999
  4. doi Analysis of NK cell/DC interaction in NK-type lymphoproliferative disease of granular lymphocytes (LDGL): role of DNAM-1 and NKp30
    Mirna Balsamo
    DI ME S Dipartimento di Medicina Sperimentale, Universita di Genova, Genova, Italy
    Exp Hematol 37:1167-75. 2009
  5. ncbi NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor
    Massimo Vitale
    Istituto Scientifico per la Ricerca sul Cancro IST, Genova, Italy
    Blood 106:566-71. 2005
  6. ncbi Selective cross-talk among natural cytotoxicity receptors in human natural killer cells
    Raffaella Augugliaro
    Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Eur J Immunol 33:1235-41. 2003
  7. ncbi A Duffy binding-like domain is involved in the NKp30-mediated recognition of Plasmodium falciparum-parasitized erythrocytes by natural killer cells
    Elie Mavoungou
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    J Infect Dis 195:1521-31. 2007
  8. pmc Expression analysis of the ligands for the Natural Killer cell receptors NKp30 and NKp44
    Andreina Byrd
    Institute for Immunology, University Heidelberg, Heidelberg, Germany
    PLoS ONE 2:e1339. 2007
  9. ncbi Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias
    Pegah Nowbakht
    Department of Research, Experimental Hematology, Basel University Hospital, Hebelstrasse 20, CH 4031 Basel, Switzerland
    Blood 105:3615-22. 2005
  10. pmc Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function
    Venkateswara Rao Simhadri
    Laboratory of Immune Therapy, Department of Internal Medicine I, Centre for Integrated Oncology Koeln Bonn, University of Cologne, Cologne, Germany
    PLoS ONE 3:e3377. 2008

Detail Information

Publications161 found, 100 shown here

  1. ncbi Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells
    Elke Pogge von Strandmann
    Department of Internal Medicine I, University Hospital of Cologne, Kerpener Str 62, D 50924 Cologne, Germany
    Immunity 27:965-74. 2007
    The activity of natural killer (NK) cells is regulated by surface receptors, which direct target cell recognition. NKp30 (Natural Cytotoxicity Receptor 3) induces target cell lysis and is also crucial for the interaction with dendritic ..
  2. ncbi Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Blood 107:2030-6. 2006
    ..Remarkably, in cytolytic assays, DNAM-1 cooperated with NKp30 in the NK-mediated killing of both immature and mature DCs and the degree of contribution of DNAM-1 appeared to ..
  3. pmc Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells
    D Pende
    Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
    J Exp Med 190:1505-16. 1999
    ..In this study, by the generation of monoclonal antibodies (mAbs), we identified NKp30, a novel 30-kD triggering receptor selectively expressed by all resting and activated human natural killer (NK) ..
  4. doi Analysis of NK cell/DC interaction in NK-type lymphoproliferative disease of granular lymphocytes (LDGL): role of DNAM-1 and NKp30
    Mirna Balsamo
    DI ME S Dipartimento di Medicina Sperimentale, Universita di Genova, Genova, Italy
    Exp Hematol 37:1167-75. 2009
    ..In this study, we analyze whether, in NK-lymphoproliferative disease of granular lymphocytes (LDGL) patients, this function could be altered and contribute to the persistence of the disease...
  5. ncbi NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor
    Massimo Vitale
    Istituto Scientifico per la Ricerca sul Cancro IST, Genova, Italy
    Blood 106:566-71. 2005
    ..While killing of immature DCs is dependent on the function of the NKp30 triggering receptor, the mechanism by which NK cells induce DC maturation is still unclear...
  6. ncbi Selective cross-talk among natural cytotoxicity receptors in human natural killer cells
    Raffaella Augugliaro
    Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Eur J Immunol 33:1235-41. 2003
    ..These receptors include NKp46, NKp30 and NKp44, collectively termed natural cytotoxicity receptors (NCR)...
  7. ncbi A Duffy binding-like domain is involved in the NKp30-mediated recognition of Plasmodium falciparum-parasitized erythrocytes by natural killer cells
    Elie Mavoungou
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    J Infect Dis 195:1521-31. 2007
    ..We showed that with NKp30-immunoglobulin and NKp46-immunoglobulin fusion proteins and DBL-1alpha peptides NCRs are involved in the NK cell-..
  8. pmc Expression analysis of the ligands for the Natural Killer cell receptors NKp30 and NKp44
    Andreina Byrd
    Institute for Immunology, University Heidelberg, Heidelberg, Germany
    PLoS ONE 2:e1339. 2007
    ..Identification of NCR ligands and their level of expression on normal and neoplastic cells has important implications for the rational design of immunotherapy strategies for cancer...
  9. ncbi Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias
    Pegah Nowbakht
    Department of Research, Experimental Hematology, Basel University Hospital, Hebelstrasse 20, CH 4031 Basel, Switzerland
    Blood 105:3615-22. 2005
    ..To detect as-yet-unknown cell-surface molecules recognized by NCRs, we developed soluble forms of NKp30, NKp44, and NKp46 as staining reagents binding the putative cognate ligands...
  10. pmc Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function
    Venkateswara Rao Simhadri
    Laboratory of Immune Therapy, Department of Internal Medicine I, Centre for Integrated Oncology Koeln Bonn, University of Cologne, Cologne, Germany
    PLoS ONE 3:e3377. 2008
    b>NKp30, a natural cytotoxicity receptor expressed on NK cells is critically involved in direct cytotoxicity against various tumor cells and directs both maturation and selective killing of dendritic cells...
  11. ncbi A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC
    M J Neville
    Medical Research Council Immunochemistry Unit, Department of Biochemistry, University of Oxford, United Kingdom
    J Immunol 162:4745-54. 1999
    ..10 known genes in this region have been precisely positioned with the order allograft inflammatory factor 1, G1, 1C7, leukocyte-specific transcript 1 (B144), lymphotoxin B, TNF, lymphotoxin A, NB6, IKBL, BAT1 (centromere to telomere)..
  12. ncbi Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan
    Hilary S Warren
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    J Immunol 175:207-12. 2005
    b>NKp30 (NCR3, CD337) is a natural cytotoxicity receptor, expressed on subsets of human peripheral blood NK cells, involved in NK cell killing of tumor cells and immature dendritic cells...
  13. ncbi Genes in a 220-kb region spanning the TNF cluster in human MHC
    S R Nalabolu
    Boyer Center for Molecular Medicine, New Haven, Connecticut 06536 0812, USA
    Genomics 31:215-22. 1996
    ..We also independently identified the BAT1 gene to be the well-conserved homologue of a previously described rat liver nuclear protein...
  14. pmc Activation of natural killer cells by newcastle disease virus hemagglutinin-neuraminidase
    Mostafa Jarahian
    German Cancer Research Center, Heidelberg, Germany
    J Virol 83:8108-21. 2009
    ..cells showed enhanced expression of ligands for the natural cytotoxicity receptors NKp44 and NKp46, but not NKp30. Ligands for the activating receptor NKG2D were partially downregulated...
  15. ncbi Functional modifications of the CD4+ and the CD8+ subset due to maternal serum
    Y E Vanderbeeken
    Service d' Immunologie, , Brussels, Belgium
    Immunopharmacol Immunotoxicol 11:397-420. 1989
    ..of a pool of maternal serum, retroplacental (MAT SR) or peripheral (MAT SP), or to a pool of male or calf serum (MALS or CS)...
  16. doi Multi-crystallin complexes exist in the water-soluble high molecular weight protein fractions of aging normal and cataractous human lenses
    K Srivastava
    Department of Vision Sciences, University of Alabama at Birmingham, Worrell Bldg, 924 S 18th Street, Birmingham, AL 35294, USA
    Exp Eye Res 87:356-66. 2008
    ..During multi-angle light scattering (MALS), the HMW proteins from cataractous lenses exhibited species with lower molecular weight range than age-matched ..
  17. ncbi Phenotypic and cytolytic activity of Macaca nemestrina natural killer cells isolated from blood and expanded in vitro
    Laurence E Shields
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Am J Primatol 68:753-64. 2006
    ..Subsets of these cells express CD56, NKp30, and NKp46...
  18. pmc X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells
    S Parolini
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Brescia, 25123 Brescia, Italy
    J Exp Med 192:337-46. 2000
    ..Other receptors involved in NK cell triggering, including CD16, NKp46, NKp44, and NKp30, displayed a normal functional capability...
  19. doi Brief report--human embryonic stem cell-derived mesenchymal progenitors possess strong immunosuppressive effects toward natural killer cells as well as T lymphocytes
    B Linju Yen
    Regenerative Medicine Research Group, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan
    Stem Cells 27:451-6. 2009
    ..and can suppress the cytotoxic effects of activated NKs, as well as downregulating the NK-activating receptors NKp30 and NKp46...
  20. ncbi Determining the absolute, chemical-heterogeneity-corrected molar mass averages, distribution, and solution conformation of random copolymers
    Imad A Haidar Ahmad
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL, 32306 4390, USA
    Anal Bioanal Chem 396:1589-98. 2010
    ..of separation by size-exclusion chromatography (SEC) with detection using multi-angle static light scattering (MALS), differential viscometry (VISC), differential refractometry (DRI), and ultraviolet absorption spectroscopy (UV) ..
  21. ncbi Complex analytical approach to characterization of the influence of carbon dioxide concentration on carbohydrate composition in Norway spruce needles
    Jana Cabálková
    Institute of Analytical Chemistry v v i, Academy of Sciences of the Czech Republic, Department of Proteomics, Veveri 97, Brno CZ 60200, Czech Republic
    J Chromatogr A 1148:189-99. 2007
    ..Application of AsFlFFF and SEC, using refractive index (RI) and multi-angle light scattering (MALS) detectors to the water-rich extracts resulted in three or four main fractions covering molar masses from 10(3) to ..
  22. ncbi Retention behaviour of amylopectins in asymmetrical flow field-flow fractionation studied by multi-angle light scattering detection
    M van Bruijnsvoort
    Division of Technical Analytical Chemistry, Centre for Chemistry and Chemical Engineering, Lund University, Sweden
    J Chromatogr A 925:171-82. 2001
    Asymmetrical flow field-flow fractionation (FFF) with multi-angle light scattering (MALS) detection was applied for the fractionation of amylopectins from four different sources...
  23. ncbi Immunohistochemical detection and distribution of enamelysin (MMP-20) in human odontogenic tumors
    T Takata
    Department of Oral Pathology, Faculty of Dentistry, Hiroshima University, Japan
    J Dent Res 79:1608-13. 2000
    ..A monoclonal antibody (203-1C7) was generated against synthesized human enamelysin oligopeptide and was used to assess the immunolocalization of ..
  24. doi Complete physicochemical characterization of DNA/chitosan complexes by multiple detection using asymmetrical flow field-flow fractionation
    Pei Lian Ma
    Department of Chemical Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal, P O 6079 Succursale Centre Ville, Montreal, Quebec, Canada H3C 3A7
    Anal Chem 82:9636-43. 2010
    Asymmetrical flow field-flow fractionation (AF4) coupled with UV-vis spectrophotometry, multiangle light scattering (MALS), and dynamic light scattering (DLS) detection was used to analyze dispersions of DNA/rhodamine B labeled chitosan (..
  25. doi CD56highCD16-CD62L- NK cells accumulate in allergic contact dermatitis and contribute to the expression of allergic responses
    Teresa Carbone
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    J Immunol 184:1102-10. 2010
    ..NKG2A, intermediate to high levels of perforin, and the activating receptors, NKG2D, NKp44, and NKp46, but lacked NKp30 and killer Ig-related receptors...
  26. pmc Selectable tolerance to herbicides by mutated acetolactate synthase genes integrated into the chloroplast genome of tobacco
    Masanori Shimizu
    Graduate School of Nutritional and Environmental Science, University of Shizuoka, Shizuoka 422 8526, Japan
    Plant Physiol 147:1976-83. 2008
    ..We generated a series of Arabidopsis (Arabidopsis thaliana) mutated ALS (mALS) genes and introduced constructs with mALS and the aminoglycoside 3'-adenyltransferase gene (aadA) into the tobacco ..
  27. ncbi [Treatment of celiac and mesenteric arteries stenoses with interventional radiologic techniques]
    Mao Qiang Wang
    Department of Interventional Radiology, People s Liberation Army General Hospital, Beijing 100853, China
    Zhonghua Wai Ke Za Zhi 43:1132-5. 2005
    ..To evaluate the safety and efficacy of the interventional techniques for management of celiac and mesenteric arteries stenoses...
  28. doi Human CD80/IL2 lentivirus-transduced acute myeloid leukaemia (AML) cells promote natural killer (NK) cell activation and cytolytic activity: implications for a phase I clinical study
    Wendy Ingram
    Department of Haematological Medicine, King s College London, London, UK
    Br J Haematol 145:749-60. 2009
    ..Expression of the activation receptors NKp30, NKp44, CD244, CD25, CD69 and HLA-DR significantly increased following allogeneic culture and a consistent ..
  29. doi Combining asymmetrical flow field-flow fractionation with light-scattering and inductively coupled plasma mass spectrometric detection for characterization of nanoclay used in biopolymer nanocomposites
    B Schmidt
    Department of Basic Sciences and Environment, University of Copenhagen, Frederiksberg, C DK 1871, Denmark
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 26:1619-27. 2009
    ..system combining asymmetrical flow field-flow fractionation (AF(4)) with multi-angle light-scattering detection (MALS) and inductively coupled plasma mass spectrometry (ICP-MS) is presented...
  30. ncbi IGF-1 gene transfer into denervated rat laryngeal muscle
    P W Flint
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21203 6402, USA
    Arch Otolaryngol Head Neck Surg 125:274-9. 1999
    ....
  31. doi Extraction of hyaluronic acid (HA) from rooster comb and characterization using flow field-flow fractionation (FlFFF) coupled with multiangle light scattering (MALS)
    Dong Young Kang
    Department of Chemistry, Hannam University, Daejeon, Korea
    J Sep Sci 33:3530-6. 2010
    ..20×10(6) and 94.7 nm, respectively. When the sample solution was filtered through a 0.45 μm disposable syringe filter, they were reduced down to 3.8×10(5) and 50.1 nm, respectively...
  32. ncbi Molecular characterization of the MalT-dependent periplasmic alpha-amylase of Escherichia coli encoded by malS
    E Schneider
    Department of Biology, University of Konstanz, Federal Republic of Germany
    J Biol Chem 267:5148-54. 1992
    b>malS, the gene encoding the periplasmic alpha-amylase, is under the regulatory control of the MalT protein, the gene activator of the Escherichia coli maltose system. We sequenced the DNA region encoding malS and its control elements...
  33. ncbi SEC-MALS characterization of microbial polyhydroxyalkanoates
    Ema Zagar
    National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia
    Biomacromolecules 5:628-36. 2004
    ..was performed using size exclusion chromatography coupled to a multi-angle light scattering detector (SEC-MALS). Absolute molar mass averages, molar mass distribution, and the radius of gyration were determined...
  34. doi Quaternary size distribution of soluble aggregates of glutathione-S-transferase-purified viral protein as determined by asymmetrical flow field flow fractionation and dynamic light scattering
    Daniel I Lipin
    Centre for Biomolecular Engineering, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Chromatogr A 1190:204-14. 2008
    ..10(3)kDa), as determined by asymmetrical flow field flow fractionation with multiple angle light scattering (AFFFF-MALS)...
  35. doi Field validation of a competitive ELISA for detection of Theileria annulata infection
    Stefanie Renneker
    Veterinary Infection Biology and Immunology, Research Center Borstel, Parkallee 22, 23845, Borstel, Germany
    Parasitol Res 106:47-53. 2009
    ..specificity, a competitive ELISA (cELISA) was developed using recombinant TaSP antigen and a monoclonal antibody (1C7) specifically binding to TaSP. Since the cELISA accurately differentiated T...
  36. doi Asymmetrical flow field-flow fractionation with multi-angle light scattering detection for the analysis of structured nanoparticles
    Andrea Zattoni
    Department of Chemistry G Ciamician, University of Bologna, via F Selmi 2, I 40126 Bologna, Italy
    J Chromatogr A 1216:9106-12. 2009
    ..Asymmetrical flow field-flow fractionation (AF4) with multi-angle light scattering (MALS) detection is able to size-separate and to characterize nanosized analytes in dispersion...
  37. pmc Natural killer cell dysfunction during acute infection with foot-and-mouth disease virus
    Felix N Toka
    Plum Island Animal Disease Center, Agricultural Research Service, USDA, Greenport, New York 11944, USA
    Clin Vaccine Immunol 16:1738-49. 2009
    ..animals are not productively infected, but virus exposure in vivo resulted in the significant induction of NKp30 and Toll-like receptor 3 expression and the moderate activation of SOCS3 and interleukin-15 receptor mRNA...
  38. doi Physicochemical features of ultra-high viscosity alginates
    Henning Storz
    Institute for Technical and Macromolecular Chemistry, University of Hamburg, Hamburg, Germany
    Carbohydr Res 344:985-95. 2009
    ..Fluorescence and (1)H NMR spectroscopies, viscometry, and multi-angle light scattering (MALS) were used for elucidation of the chemical structure, molar mass, and coil size...
  39. ncbi Reliability and validity of the upper-extremity Motor Activity Log-14 for measuring real-world arm use
    Gitendra Uswatte
    Department of Psychology, University of Alabama, Birmingham, AL 35294, USA
    Stroke 36:2493-6. 2005
    ..This article examines the psychometrics of the 14-item version of this instrument in 2 chronic stroke samples with mild-to-moderate upper-extremity hemiparesis...
  40. ncbi Masticatory function after unilateral distal extension removable partial denture treatment: intra-individual comparison with opposite dentulous side
    Wacharasak Tumrasvin
    Removable Prosthodontics, Department of Masticatory Function Rehabilitation, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Japan
    J Med Dent Sci 52:35-41. 2005
    ..Both masticatory parameters were evaluated separately on each chewing side. MAls and MBFs obtained from the RPD replaced side (0.65 +/- 0...
  41. doi Particle size characterization by quadruple-detector hydrodynamic chromatography
    Amandaa K Brewer
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL, 32306 4390, USA
    Anal Bioanal Chem 393:295-302. 2009
    ..a quadruple-detector hydrodynamic chromatography (HDC) method utilizing static multiangle light scattering (MALS), quasi-elastic light scattering (QELS), differential viscometry (VISC), and differential refractometry (DRI), and ..
  42. ncbi Comparative evaluation of size-exclusion chromatography and viscometry for the characterisation of cellulose
    Anne Laurence Dupont
    Centre de Recherches sur la Conservation, Centre National de la Recherche Scientifique, Ministère de la Culture et de la Communication, Museum national d histoire naturelle, 75005 Paris, France
    J Chromatogr A 1026:129-41. 2004
    The analysis using size-exclusion chromatography (SEC) with multi-angle light scattering (MALS) and differential refractive index (DRI) detection of cellulose dissolved in lithium chloride/N,N-dimethylacetamide (LiCI/DMAc) is evaluated ..
  43. doi Identification of the transcription factor responsible for L-malate-dependent regulation in the marine Antarctic bacterium Pseudoalteromonas haloplanktis TAC125
    Rosanna Papa
    Department of Public Health Sciences, La Sapienza University, Rome, Italy
    FEMS Microbiol Lett 295:177-86. 2009
    ..Recently, a functionally active two-component system consisting of malS and malR genes possibly involved in the expression of a C4-dicarboxylate transporter system (dctAB operon) was ..
  44. ncbi Distribution analysis of ultra-high molecular mass poly(ethylene oxide) containing silica particles by size-exclusion chromatography with dual light-scattering and refractometric detection
    Bedrich Porsch
    Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq 2, 16206 Prague 6, Czech Republic
    J Chromatogr A 1068:249-60. 2005
    ..SEC) systems, connected in-line either to a low-angle light scattering (LALS) or to a multiangle light scattering (MALS) detector, are employed for determination of molecular mass distributions (MMD) of poly(ethylene oxide) (PEO) ..
  45. ncbi NKG2D and natural cytotoxicity receptors are involved in natural killer cell interaction with self-antigen presenting cells and stromal cells
    Alessandro Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, c o CBA Torre A1, Largo R Benzi 10, 16132 Genoa, Italy
    Ann N Y Acad Sci 1109:47-57. 2007
    ..The natural cytotoxicity receptors NKp30 and NKp46 are responsible for the delivery of lethal hit to APC, whereas NKG2D-activating receptor, the ligand of ..
  46. doi Celiac revascularization as a requisite for treating the median arcuate ligament syndrome
    Xiujie Wang
    Department of Surgery, Englewood Hospital and Medical Center, Englewood, NJ 07631, USA
    Ann Vasc Surg 22:571-4. 2008
    Median arcuate ligament syndrome (MALS) is a rare and often misunderstood condition characterized by compression of the proximal portion of the celiac artery by the median arcuate ligament...
  47. doi The natural cytotoxicity receptor NKp46 is dispensable for IL-22-mediated innate intestinal immune defense against Citrobacter rodentium
    Naoko Satoh-Takayama
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris, France
    J Immunol 183:6579-87. 2009
    Natural cytotoxicity receptors (including NKp30, NKp44, and NKp46 in humans and NKp46 in mice) are type I transmembrane proteins that signal NK cell activation via ITAM-containing adapter proteins in response to stress- and pathogen-..
  48. doi Liposome fractionation and size analysis by asymmetrical flow field-flow fractionation/multi-angle light scattering: influence of ionic strength and osmotic pressure of the carrier liquid
    Stefan Hupfeld
    Drug Transport and Delivery Group, Department of Pharmacy, University of Tromsø, N 9037 Tromsø, Norway
    Chem Phys Lipids 163:141-7. 2010
    Asymmetrical flow field-flow fractionation (AsFlFFF)/multi-angle light scattering (MALS) was employed for studying filter-extruded liposomes in carrier solutions with different ionic strength and osmolarity...
  49. doi The application of the mutated acetolactate synthase gene from rice as the selectable marker gene in the production of transgenic soybeans
    Makoto Tougou
    National Agricultural Research Center for Tohoku Region NARCT, Morioka, Iwate, Japan
    Plant Cell Rep 28:769-76. 2009
    ..system, we used the acetolactate synthase (ALS)-inhibiting herbicide-resistance gene derived from rice (Os-mALS gene) as a selectable marker gene instead of that derived from bacteria, which interfered with the cultivation and ..
  50. doi Single walled carbon nanotube length determination by asymmetrical-flow field-flow fractionation hyphenated to multi-angle laser-light scattering
    Julien Gigault
    Université de Pau et des Pays de l Adour UPPA CNRS, Laboratoire de Chimie Analytique Bio Inorganique et Environnement, UMR IPREM 5254, Technopôle Hélioparc, Av Du président Angot, 64000 Pau, France
    J Chromatogr A 1217:7891-7. 2010
    Asymmetrical flow field-flow fractionation (AFlFFF) hyphenated to multi-angle laser-light scattering (MALS) was evaluated in order to determine single walled carbon nanotube (SWCNT) length distribution...
  51. ncbi Isolates of Theileria annulata collected from different parts of India show phenotypic and genetic diversity
    A Manuja
    Department of Veterinary Epidemiology and Preventive Medicine, CCS Haryana Agricultural University, Hisar 125004, Haryana, India
    Vet Parasitol 137:242-52. 2006
    ..Phenotypic polymorphism was also revealed by T. annulata schizont-specific monoclonal antibodies (Mabs), viz. 1C7, 1E11, 2G2 and EU-106, which recognized variable number of cells in indirect fluorescent antibody and indirect ..
  52. doi Quantitative characterization of virus-like particles by asymmetrical flow field flow fractionation, electrospray differential mobility analysis, and transmission electron microscopy
    Leonard F Pease
    National Institute of Standards and Technology NIST, Gaithersburg, Maryland, USA
    Biotechnol Bioeng 102:845-55. 2009
    ..analysis (ES-DMA), asymmetric flow field-flow fractionation with multi-angle light scattering detection (AFFFF-MALS) and transmission electron microscopy (TEM)...
  53. doi A detailed analysis of biodegradable nanospheres by different techniques--a combined approach to detect particle sizes and size distributions
    Christian Augsten
    Martin Luther University of Halle Wittenberg, Institute of Pharmacy, 06120 Halle, Germany
    J Pharm Biomed Anal 47:95-102. 2008
    ..The flow field-flow fractionation (FlFFF) fractograms in combination with multi-angle light scattering (MALS) allowed an easy detection of maximum particle sizes what is most important for parenteral systems...
  54. doi Increased killing of liver NK cells by Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepatocyte necrosis in virus-induced liver failure
    Yong Zou
    Department of Infectious Disease, Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Immunol 184:466-75. 2010
    ..the accumulation of hepatic NK cells and increased expression of FasL and natural cytotoxicity receptors (NKp30 and NKp46) on the peripheral NK cells from patients with HBV-ACLF were correlated with disease progression...
  55. pmc Fatal cases of Theileria annulata infection in calves in Portugal associated with neoplastic-like lymphoid cell proliferation
    Sandra Branco
    Instituto de Ciências Agrárias e Ambientais Mediterrânicas, Departamento de Medicina Veterinaria, Universidade de Evora, Pólo da Mitra, Ap 94, Evora, Portugal
    J Vet Sci 11:27-34. 2010
    ..annulata infected cells in these nodules were also identified by IHC through the use of two monoclonal antibodies (1C7 and 1C12) which are diagnostic for the parasite...
  56. doi Anticoagulant activity of a sulfated polysaccharide from the green alga Arthrospira platensis
    Hatem Majdoub
    Laboratoire Polymères, Biopolymères et Matériaux Organiques, Faculte des Sciences, Monastir, 5000 Monastir, Tunisia
    Biochim Biophys Acta 1790:1377-81. 2009
    ..The polysaccharide of culture medium from Arthrospira platensis was extracted by ultrafiltration, partially characterized and assayed for anticoagulant activity...
  57. ncbi A topological model of the baseplate of lactococcal phage Tuc2009
    Giuliano Sciara
    Architecture et Fonction des Macromolecules Biologiques, UMR 6098 CNRS, 163 Avenue de Luminy Case 932, Marseille Cedex 09, France
    J Biol Chem 283:2716-23. 2008
    ..chromatography coupled to on-line UV-visible absorbance, light scattering, and refractive index detection (MALS/UV/RI)...
  58. doi Hydrodynamic versus size exclusion chromatography characterization of alternan and comparison to off-line MALS
    Samantha L Isenberg
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306 4390, USA
    Biomacromolecules 11:2505-11. 2010
    ..Results from packed-column HDC with multiangle static light scattering (MALS) detection compare favorably to results from off-line MALS analysis, and HDC results are obtained in a fraction of ..
  59. ncbi Association of HLA-A*3303-B*4403-DRB1*1302 haplotype, but not of TNFA promoter and NKp30 polymorphism, with postherpetic neuralgia (PHN) in the Japanese population
    M Sato
    Department of Research, Tokyo Metropolitan Red Cross Blood Center, Tokyo, 150 0012 Japan
    Genes Immun 3:477-81. 2002
    ..HLA-A, -B, -DRB1, tumor necrosis factor alpha (TNFA) promoter, and a natural killer cell activating receptor, NKp30 polymorphisms with PHN...
  60. ncbi Characterization of gelatine and acid soluble collagen by size exclusion chromatography coupled with multi angle light scattering (SEC-MALS)
    Michael Meyer
    Forschungsinstitut für Leder und Kunststoffbahnen gGmbH, Meissner Ring 1 5, D 09599 Freiberg, Germany
    Biomacromolecules 4:1727-32. 2003
    ..hide gelatine were analyzed by size exclusion chromatography (SEC) coupled with multi angle light scattering (MALS). The SEC system was calibrated with ASC and its cyan bromide cleavage products...
  61. doi Characterization of high-molecular-weight nonnative aggregates and aggregation kinetics by size exclusion chromatography with inline multi-angle laser light scattering
    Yi Li
    Department of Chemical Engineering, University of Delaware, Newark, Delaware 19716, USA
    J Pharm Sci 98:3997-4016. 2009
    Size exclusion chromatography with an inline multi-angle light scattering detector (SEC-MALS) was assessed as a means to characterize and monitor the formation of soluble, high-molecular-weight (HMW) protein aggregates so as to better ..
  62. doi A high throughput method for enrichment of natural killer cells and lymphocytes and assessment of in vitro cytotoxicity
    Edward C So
    Division of Research and Development and Surgical Service, Baltimore Veterans Administration Medical Center, 10 N Greene Street, 5C Surgical Services Area, Baltimore, MD 21201, USA
    J Immunol Methods 394:40-8. 2013
    ..NK cell activation marker expression (including CD94, NKG2D, NKp30, NKp46, DNAM-1, 2B4, KIR2DL1/S1, KIR2DL2/L3, intracellular granzyme B, and perforin) was similar when comparing NK ..
  63. ncbi In vitro papillomavirus capsid assembly analyzed by light scattering
    Greg L Casini
    Section of Pediatric Hematology Oncology, University of Colorado School of Medicine, Denver, CO 80262, USA
    Virology 325:320-7. 2004
    ..coli and analyzed for the kinetics of in vitro capsid self-assembly using multi-angle light scattering (MALS). Pentamers self-assembled into capsid-like structures at a rate that was a function of protein concentration...
  64. ncbi Field programming in frit inlet asymmetrical flow field-flow fractionation/multiangle light scattering: application to sodium hyaluronate
    Heejeong Lee
    Department of Chemistry, Yonsei University, Seoul 120 749, South Korea
    J Chromatogr A 1089:203-10. 2005
    ..were performed with on-line coupling of the field programming FI-AFlFFF and multiangle light scattering (MALS) detection...
  65. doi Molecular characterization of solution styrene-butadiene rubber: thermal field-flow fractionation/multi-angle light scattering studies
    You Jin Choi
    Department of Chemistry, Hannam University, Daejeon 305 811, South Korea
    J Chromatogr A 1314:306-12. 2013
    ..We employ thermal field-flow fractionation (ThFFF), combined with online multi-angle light scattering (MALS), as most suited for characterization of solutions containing the microgels since they can be characterized in toto ..
  66. pmc Treatment of median arcuate ligament syndrome via traditional and robotic techniques
    Jae S You
    John A Burns School of Medicine, University of Hawai i, Honolulu, HI
    Hawaii J Med Public Health 72:279-81. 2013
    Median arcuate ligament syndrome (MALS) is a rare entity characterized by extrinsic compression of the celiac artery and symptoms of postprandial epigastric pain, nausea, vomiting, and weight loss mimicking mesenteric ischemia...
  67. ncbi Regulation of serotonin 5-HT2C receptors by chronic ligand exposure
    Mark G Devlin
    Department of Pharmacology, University of Melbourne, Parkville, 3010 Victoria, Australia
    Eur J Pharmacol 498:59-69. 2004
    ..pretreatment on human 5-hydroxytryptamine2C (5-HT2C) receptors was examined in CHO cells expressing high (CHO-1C7; 67+/-3 pmol/mg) or low (CHO-1C19; 72+/-10 fmol/mg) levels of the receptor...
  68. ncbi Effect of dissolution temperature on the structures of sodium hyaluronate by flow field-flow fractionation/multiangle light scattering
    Heejeong Lee
    Department of Chemistry, Yonsei University, Seoul, 120 749, South Korea
    J Chromatogr A 1131:185-91. 2006
    ..temperature conditions, using on-line flow field-flow fractionation (FlFFF) and multiangle light scattering (MALS)...
  69. ncbi Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy
    Katja Jores
    Institute of Pharmacy, Department of Pharmaceutical Technology, Free University of Berlin, Kelchstr 31, 12169 Berlin, Germany
    J Control Release 95:217-27. 2004
    ..PCS) and laser diffraction (LD), field-flow fractionation (FFF) with multi-angle light scattering detection (MALS), and cryo transmission electron microscopy (cryo TEM)...
  70. ncbi Synaptic transmission regulated by a presynaptic MALS/Liprin-alpha protein complex
    Olav Olsen
    Departments of Physiology and Cellular and Molecular Pharmacology, University of California San Francisco, 600 16th Street, San Francisco, CA, USA
    Curr Opin Cell Biol 18:223-7. 2006
    ..Mutations in genes encoding components of the highly conserved MALS/CASK/Mint-1 complex cause presynaptic defects...
  71. pmc Differential expression of natural killer cell activating receptors in blood versus bone marrow in patients with monoclonal gammopathy
    Regis T Costello
    Laboratoire d Hematologie, Hopital Nord, Marseille, France
    Immunology 139:338-41. 2013
    ..and multiple myeloma (MM), normal natural cytotoxicity receptors (NCR) expression (NCR1/NKp46, NCR2/NKp44, NCR3/NKp30) is observed in natural killer (NK) cells...
  72. doi Preparation of soluble isotopically labeled NKp30, a human natural cytotoxicity receptor, for structural studies using NMR
    Lena Grave
    Department of Biochemistry, Charles University Prague, Praha, Czech Republic
    Protein Expr Purif 86:142-50. 2012
    ..or (15)NH(4)Cl in combination with all-(13)C-d-glucose allowing to produce homogenous soluble monomeric NKp30 in several formats needed for advanced NMR studies...
  73. doi Mimicking an induced self phenotype by coating lymphomas with the NKp30 ligand B7-H6 promotes NK cell cytotoxicity
    Christian Kellner
    Division of Stem Cell Transplantation and Immunotherapy, Department of Medicine II, Christian Albrechts University Kiel, 24105 Kiel, Germany
    J Immunol 189:5037-46. 2012
    Induced self expression of the NKp30 ligand B7-H6 facilitates NK cell-mediated elimination of stressed cells...
  74. pmc Production and characterization of an alloplasmic and monosomic addition line of Brassica rapa carrying the cytoplasm and one chromosome of Moricandia arvensis
    Kota Tsutsui
    Laboratory of Plant Breeding, Faculty of Agriculture, Utsunomiya University, 350 Minemachi, Utsunomiya, Tochigi 321 8505, Japan United Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3 5 8 Saiwai, Fuchu, Tokyo 183 8509, Japan
    Breed Sci 61:373-9. 2011
    ..rapa 'Ko1-303' employing embryo rescue. Alloplasmic and monosomic addition lines of B. rapa (Allo-MALs, 2n = 21) were obtained from backcrossed progeny of three BC(3) plants (2n = 21, 22 and 23) without embryo rescue...
  75. pmc NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors
    Christopher A Alvarez-Breckenridge
    Medical Scientist Training Program, Ohio State University Medical Center, Columbus, Ohio, USA
    Nat Med 18:1827-34. 2012
    ..This enhanced killing depended on the NK cell natural cytotoxicity receptors (NCRs) NKp30 and NKp46, whose ligands are upregulated in oHSV-infected glioblastoma cells...
  76. pmc Rescue of impaired NK cell activity in hodgkin lymphoma with bispecific antibodies in vitro and in patients
    Katrin S Reiners
    Department I of Internal Medicine, Laboratory of Immunotherapy, University Clinic of Cologne, Cologne, Germany
    Mol Ther 21:895-903. 2013
    ..Impaired NK cell function correlated with elevated serum levels of soluble ligands for NK cell receptors NKp30 (BAG6/BAT3) and NKG2D (MICA), factors known to constrict NK cell function...
  77. pmc Natural cytotoxicity receptors: broader expression patterns and functions in innate and adaptive immune cells
    Kelly Hudspeth
    Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research Center Rozzano, Milan, Italy Department of Medical Biotechnologies and Translational Medicine, University of Milan Milan, Italy
    Front Immunol 4:69. 2013
    ..The three known NCRs, NKp46, NKp44, and NKp30, comprise a family of germ-line encoded Ig-like trans-membrane (TM) receptors...
  78. doi Pre-treatment with Mycobacterium avium-derived lipids reduces the macrophage response to interferon γ in BCG-vaccinated mice
    Daqing Yang
    Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China
    J Med Microbiol 62:980-7. 2013
    ..In this study, BCG-vaccinated mice pre-treated with M. avium-derived lipids (MALs) showed a higher mycobacterial load and increased infiltration of inflammatory cells compared to control mice ..
  79. ncbi Cell type heterogeneity of cytokeratin expression in complex epithelia and carcinomas as demonstrated by monoclonal antibodies specific for cytokeratins nos. 4 and 13
    G N Van Muijen
    Exp Cell Res 162:97-113. 1986
    Three monoclonal antibodies, 1C7, 2D7 and 6B10, directed against cytokeratins of human esophagus were isolated and characterized by one- and two-dimensional gel electrophoresis and by immunohistochemical staining on sections of human ..
  80. doi Detailed characterization of hyaluronan using aqueous size exclusion chromatography with triple detection and multiangle light scattering detection
    Patricia S Harmon
    Bausch and Lomb, Inc, Global Research and Development, Rochester, New York 14609, USA
    J Biomed Mater Res B Appl Biomater 100:1955-60. 2012
    ..In this study, we compared size exclusion chromatography (SEC) with online multiangle light scattering (SEC-MALS) and SEC with triple detection (SEC-TD) experiments for HA analysis...
  81. doi A new analytical approach based on asymmetrical flow field-flow fractionation coupled to ultraviolet spectrometry and light scattering detection for SWCNT aqueous dispersion studies
    Julien Gigault
    Université de Pau et des Pays de l Adour CNRS, Laboratoire de Chimie Analytique Bio Inorganique et Environnement, UMR IPREM 5254 Technopôle Hélioparc, Av du Président Angot 64053, Pau Cedex France
    Analyst 137:917-23. 2012
    ..flow field-flow fractionation (A4F) coupled to Ultraviolet spectrometry (UV) and multi-angle light scattering (MALS) for the study of single-walled carbon nanotube (SWCNT) dispersion in aqueous solutions containing a surfactant...
  82. pmc Changes in natural killer cell subsets in pediatric liver transplant recipients
    Betty Pham
    Division of Abdominal Transplantation, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305 5492, USA
    Pediatr Transplant 16:176-82. 2012
    ..PBMCs were isolated and analyzed for the levels of NK cell activation receptors NKp30, NKp46, and NKG2D in the CD56(dim) CD16(+) and CD56(bright) CD16(+/-) subsets of NK cells...
  83. pmc NMR structures of the transmembrane domains of the α4β2 nAChR
    Vasyl Bondarenko
    Department of Anesthesiology, University of Pittsburgh, School of Medicine, PA 15260, USA
    Biochim Biophys Acta 1818:1261-8. 2012
    ..NMR experiments and size exclusion chromatography-multi-angle light scattering (SEC-MALS) analysis demonstrated that the TM domains of α4 and β2 interacted with each other and spontaneously formed ..
  84. doi Engagement of NKp30 on Vδ1 T cells induces the production of CCL3, CCL4, and CCL5 and suppresses HIV-1 replication
    Kelly Hudspeth
    Laboratory of Clinical and Experimental Immunology, Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Clinico Humanitas, Via Alessandro Manzoni 113, Rozzano, Milan, Italy
    Blood 119:4013-6. 2012
    ..Here we demonstrate that the engagement of NKp30, one of the NCRs expressed de novo on Vδ1 T cells after stimulation, triggers the production of high levels of ..
  85. doi COPD treatment: real life and experimental effects on peripheral NK cells, their receptors expression and their IFN-γ secretion
    C Folli
    Allergy and Respiratory Diseases Clinic, DIMI University of Genova, IRCCS AOU San Martino IST, Genova, Italy
    Pulm Pharmacol Ther 25:371-6. 2012
    ..and budesonide, administered alone or in combination, are able to modulate the surface expression of activating (NKp30, NKp44, NKp46 and NKG2D) and inhibitory (KIR2DL2/L3, KIR3DL1 and NKG2A) receptors on peripheral blood NK cells of ..
  86. ncbi Molecular characterization of multivalent bioconjugates by size-exclusion chromatography with multiangle laser light scattering
    Jacob F Pollock
    Department of Bioengineering, University of California at Berkeley, Berkeley, California, USA
    Bioconjug Chem 23:1794-801. 2012
    ..with multiangle laser light scattering was paired with refractive index detection and ultraviolet spectroscopy (SEC-MALS-RI-UV) to characterize the reaction efficiency, degree of substitution, and valency of the products of conjugation ..
  87. doi In situ formation of nanoparticles upon dispersion of melt extrudate formulations in aqueous medium assessed by asymmetrical flow field-flow fractionation
    Johanna Kanzer
    Drug Transport and Delivery Group, Department of Pharmacy, University of Tromsø, N 9037 Tromsø, Norway
    J Pharm Biomed Anal 53:359-65. 2010
    ..PCS) and asymmetrical flow field-flow fractionation (AsFlFFF) with subsequent online multi-angle light-scattering (MALS) particle size analysis...
  88. doi Characterization of fullerene colloidal suspension in a cell culture medium for in vitro toxicity assessment
    Haruhisa Kato
    Polymer Standards Section Japan PSSJ, National Metrology Institute of Japan NMIJ, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba Central 5, Higashi 1 1 1, Tsukuba, Ibaraki, 305 8565 Japan
    Mol Biosyst 6:1238-46. 2010
    ..of the fullerene colloidal nanoparticles was successfully performed using AFFFF-multi angle light scattering (MALS) and DLS methods...
  89. ncbi Identification, molecular cloning and functional characterization of NKp46 and NKp30 natural cytotoxicity receptors in Macaca fascicularis NK cells
    A De Maria
    Department of Internal Medicine, University of Genoa, Italy
    Eur J Immunol 31:3546-56. 2001
    ..fascicularis NCR. NCR-specific mAb reactivity (anti-NKp46 and anti-NKp30) was present on M. fascicularis PBMC and on NK cell cultures...
  90. pmc Escherichia coli DegP protease cleaves between paired hydrophobic residues in a natural substrate: the PapA pilin
    C Hal Jones
    SIGA Technologies, Inc, Corvallis, Oregon 97333, USA
    J Bacteriol 184:5762-71. 2002
    ..To date, four natural targets for DegP have been described: colicin A lysis protein, pilin subunits and MalS from E. coli, and high-molecular-weight adherence proteins from Haemophilus influenzae...
  91. ncbi Recognition of multiple Mycoplasma bovis antigens by monoclonal antibodies
    Bela Denes
    Central Veterinary Institute, Budapest, Hungary
    Hybrid Hybridomics 22:11-6. 2003
    ..the results, the obtained MAbs recognize the antigen determinants of the following molecular weights: 1B11: 63 kDa, 1C7: 63 kDa, 2C5: 22, 25 and 27 kDa, 2C9: 69 kDa, 3G12: 67, 69 and 72 kDa, 4H9: 63 kDa, 5B8: 22, 25 and 27 kDa, 5D3: 22,..
  92. doi CD16 cross-linking induces increased expression of CD56 and production of IL-12 in peripheral NK cells
    Maria Elena Marquez
    Laboratorio de Patología Celular y Molecular, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Cell Immunol 264:86-92. 2010
    ..upon CD16 cross-linking up-regulates the expression of activating markers and receptors such as CD25, CD69, NKp44, NKp30, CD40L and the intensity of CD56 expression...
  93. ncbi Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors
    Alessandro Poggi
    Laboratory of Immunology, National Institute for Cancer Research, University of Genoa, Genoa, Italy
    J Immunol 174:2653-60. 2005
    ..evidence that tumor cells can induce apoptosis of NK cells by engaging the natural cytotoxicity receptors (NCR) NKp30, NKp44, and NKp46...
  94. doi A novel immunomodulatory mechanism of ribavirin in suppressing natural killer cell function
    Henry Ogbomo
    Institut fur Medizinische Virologie, Klinikum der Johann Wolfgang Goethe Universitat, Paul Ehrlich Str 40, 60596 Frankfurt am Main, Germany
    Biochem Pharmacol 79:188-97. 2010
    ..IL-15-induced increased expression and hence function of NK cell activating receptors including NKp30, NKp44, NKp46 and NKG2D were selectively down-regulated and impaired...
  95. ncbi Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97
    ANDRE BACHMANN
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, 40225 Dusseldorf, Germany
    J Cell Sci 117:1899-909. 2004
    ..biochemical and cell culture studies have revealed that various mammalian MAGUKs can interact with mLin-7/Veli/MALS, a small PDZ-domain protein...
  96. ncbi Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis
    A Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Italy
    Annu Rev Immunol 19:197-223. 2001
    ..Three novel, NK-specific, triggering surface molecules (NKp46, NKp30, and NKp44) have been identified...
  97. pmc NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease
    Nobuyoshi Hanaoka
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol 185:5732-42. 2010
    ..As a consequence, the functional capacities of the TCR, the low-affinity Fc receptor for IgG, and the NKp30 and NKp46 natural cytotoxicity receptors, which all signal through CD3ζ, are impaired...
  98. doi Characterization of sodium hyaluronate blends using frit inlet asymmetrical flow field-flow fractionation and multiangle light scattering
    Muhammad Ali
    Department of Chemistry, Yonsei University, Seoul 120 749, South Korea
    Anal Bioanal Chem 402:1269-76. 2012
    ..NaHA using flow field-flow fractionation and multiangle light scattering-differential refractive index (FlFFF-MALS-DRI)...
  99. doi Multi-wall carbon nanotube aqueous dispersion monitoring by using A4F-UV-MALS
    Julien Gigault
    Laboratoire de Chimie Analytique Bioinorganique et Environnement, UMR IPREM 5254 UPPA CNRS Technopôle Hélioparc, Université de Pau et des Pays de l Adour UPPA, Pau Cedex, France
    Anal Bioanal Chem 401:3345-53. 2011
    ..of asymmetrical flow field-flow fractionation (A4F) hyphenated to UV detector and multi-angle light scattering (MALS) was investigated for accurately determining multi-walled carbon nanotube (MWCNT) length and its corresponding ..
  100. pmc Direct binding of human NK cell natural cytotoxicity receptor NKp44 to the surfaces of mycobacteria and other bacteria
    Semih Esin
    Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, University of Pisa, Via San Zeno 35 39, 56127 Pisa, Italy
    Infect Immun 76:1719-27. 2008
    ..An induction of the surface expression of NKp44, but not of NKp30 or NKp46, was observed after 3 and 4 days of in vitro stimulation with live BCG...
  101. doi Characterizing string-of-pearls colloidal silica by multidetector hydrodynamic chromatography and comparison to multidetector size-exclusion chromatography, off-line multiangle static light scattering, and transmission electron microscopy
    Amandaa K Brewer
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306 4390, USA
    Anal Chem 83:3068-75. 2011
    ..that the molar mass and radius of gyration obtained by HDC with multiangle static light scattering detection (HDC/MALS) compare quite favorably to those determined by off-line MALS analysis under otherwise identical conditions...

Research Grants57

  1. Anthracycline cardiotoxicity and calsequestrin function
    SUSAN SHADLE; Fiscal Year: 2002
    ..behavior of calsequestrin using flow-field flow fractionation and multi-angle light scattering detection (flow-FFF/MALS); 3) to probe the ability of anthracyclines to inhibit calcium binding to calsequestrin using Ca-45 competitive ..
  2. Ligand for Natural Cytotoxicity Receptor NKp44
    PORUNELLOOR MATHEW; Fiscal Year: 2007
    ..Among the activation receptors, the natural cytotoxicity receptors (NCRs), including NKp46, NKp44 and NKp30 are NK- specific and play a critical role in the regulation of natural cytolytic function...
  3. STRUCTURE AND FUNCTION OF NATURAL KILLER CELL RECEPTORS
    Roy A Mariuzza; Fiscal Year: 2010
    ..m157) for Ly49s, and the identification of novel, non-MHC ligands for the orphan NK receptors KLRG1, NKp80, and NKp30. We propose to establish the structural basis for each of these newly discovered NK receptor-ligand interactions ..
  4. Synaptic signaling regulated by MALS family PDZ proteins
    Roger Nicoll; Fiscal Year: 2007
    ..In mammals, close homologues of LIN-2 (CASK), LIN-7 (MALS/Veli) and LIN-10 (Mint/X11) have all been identified and the LIN-2/-7/-10 complex occurs at highest levels at pre- ..
  5. Synaptic signaling regulated by MALS family PDZ proteins
    David Bredt; Fiscal Year: 2006
    ..In mammals, close homologues of LIN-2 (CASK), LIN-7 (MALS/Veli) and LIN-10 (Mint/X11) have all been identified and the LIN-2/-7/-10 complex occurs at highest levels at pre- ..
  6. The role of NK cells in human M. Tuberculosis infection
    Ramakrishna Vankayalapati; Fiscal Year: 2009
    ..These findings will facilitate development of immunomodulatory strategies to boost the immune response to M. tuberculosis, including multidrug-resistant tuberculosis. ..
  7. Modulation of T cell Homeostasis in Myelodysplastic Syndrome (MDS)
    Javier Pinilla; Fiscal Year: 2010
    ..Mechanistic studies will aide our understanding of T-cell immunity and improve our ability to utilize this form of immunotherapy and other forms for the treatment of cancer in general. ..
  8. Occupational Trunk Flexion and Neuromuscular Disturbance
    Maury A Nussbaum; Fiscal Year: 2010
    ..Results will guide future studies and/or epidemiologic investigations regarding the mechanism of cumulative risk from flexed working postures. ..
  9. Modulation of T cell Homeostasis in Myelodysplastic Syndrome (MDS)
    Pearlie K Epling Burnette; Fiscal Year: 2009
    ....
  10. Home-Based Automated Therapy of Arm Function After Stroke Via Tele-Rehabilitation
    Gitendra Uswatte; Fiscal Year: 2010
    ..Reducing the cost of and increasing access to efficacious upper-extremity rehabilitation has the potential to significantly reduce the burden of stroke on patients, their families and the healthcare system. ..
  11. Cytolytic antibodies:Bridging the gap between the innate and adaptive immune resp
    Galit Alter; Fiscal Year: 2010
    ..This proposal therefore aims to define the role of ADCC in HIV- 1 infection to determine whether the generation of these responses should be a priority in our efforts to design an effective prophylactic or therapeutic vaccine. ..
  12. Occupational Trunk Flexion and Neuromuscular Disturbance
    Maury Nussbaum; Fiscal Year: 2009
    ..Results will guide future studies and/or epidemiologic investigations regarding the mechanism of cumulative risk from flexed working postures. ..
  13. Home-Based Automated Therapy of Arm Function After Stroke Via Tele-Rehabilitation
    Gitendra Uswatte; Fiscal Year: 2009
    ..Reducing the cost of and increasing access to efficacious upper-extremity rehabilitation has the potential to significantly reduce the burden of stroke on patients, their families and the healthcare system. ..
  14. Cytolytic antibodies:Bridging the gap between the innate and adaptive immune resp
    Galit Alter; Fiscal Year: 2010
    ..This proposal therefore aims to define the role of ADCC in HIV- 1 infection to determine whether the generation of these responses should be a priority in our efforts to design an effective prophylactic or therapeutic vaccine. ..
  15. Tumor Immunology Training Program
    Julie Djeu; Fiscal Year: 2007
    ..This in-depth training will allow the postdoctoral fellow to become a successful researcher in molecular and translational immunology in academia or industry. ..
  16. OCCUPATIONAL SAFETY AND HEALTH TRAINING GRANT
    Maury Nussbaum; Fiscal Year: 2007
    ..The program plan described here is intended to continue in a similar fashion, and improve in several key areas, including minority recruitment and retention. ..
  17. IN UTERO STEM CELL TRANSPLANTATION
    Laurence Shields; Fiscal Year: 2002
    ....
  18. AGING EFFECTS ON INTERMITTENT WORK CAPACITY
    Maury Nussbaum; Fiscal Year: 2002
    ..The quantification of intermittent work capacity is an important first step towards effective risk assessment, job evaluation, and reduction of economic and medical costs associated with workplace injuries. ..
  19. Occupational Trunk Flexion and Neuromuscular Disturbance
    Maury Nussbaum; Fiscal Year: 2007
    ..Results will guide future studies and/or epidemiologic investigations regarding the mechanism of cumulative risk from flexed working postures. ..
  20. TARGETED DRUG THERAPY FOR LGL LEUKEMIA
    Pearlie K Epling Burnette; Fiscal Year: 2007
    ..Results of these studies should identify important molecular targets for drug development in bone marrow failure syndromes. ..
  21. Anergizing effect of NK cell receptor expression on HIV-specific CD8+ T cells
    Galit Alter; Fiscal Year: 2007
    ....
  22. Risk factors and controls for falls from heights
    Maury Nussbaum; Fiscal Year: 2006
    ..abstract_text> ..
  23. TARGETED DRUG THERAPY FOR LGL LEUKEMIA
    Pearlie K Epling Burnette; Fiscal Year: 2005
    ..Results of these studies should identify important molecular targets for drug development in bone marrow failure syndromes. ..
  24. Facilitating Cells for Fetal Hematopoietic Transplant
    Laurence Shields; Fiscal Year: 2005
    ..Future directions will be towards the use of this model to explore the role and function of developmentally regulated adhesion molecules and their receptors as they relate to fetal hematopoietic transplantation. ..