NCR3

Summary

Gene Symbol: NCR3
Description: natural cytotoxicity triggering receptor 3
Alias: 1C7, CD337, LY117, MALS, NKp30, natural cytotoxicity triggering receptor 3, NK-p30, activating NK-A1 receptor, activating natural killer receptor p30, lymphocyte antigen 117, natural killer cell p30-related protein
Species: human
Products:     NCR3

Top Publications

  1. Pogge von Strandmann E, Simhadri V, Von Tresckow B, Sasse S, Reiners K, Hansen H, et al. Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells. Immunity. 2007;27:965-74 pubmed
    The activity of natural killer (NK) cells is regulated by surface receptors, which direct target cell recognition. NKp30 (Natural Cytotoxicity Receptor 3) induces target cell lysis and is also crucial for the interaction with dendritic ..
  2. Nowbakht P, Ionescu M, Rohner A, Kalberer C, Rossy E, Mori L, et al. Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias. Blood. 2005;105:3615-22 pubmed
    ..To detect as-yet-unknown cell-surface molecules recognized by NCRs, we developed soluble forms of NKp30, NKp44, and NKp46 as staining reagents binding the putative cognate ligands...
  3. Neville M, Campbell R. A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC. J Immunol. 1999;162:4745-54 pubmed
    ..10 known genes in this region have been precisely positioned with the order allograft inflammatory factor 1, G1, 1C7, leukocyte-specific transcript 1 (B144), lymphotoxin B, TNF, lymphotoxin A, NB6, IKBL, BAT1 (centromere to telomere)..
  4. Nalabolu S, Shukla H, Nallur G, Parimoo S, Weissman S. Genes in a 220-kb region spanning the TNF cluster in human MHC. Genomics. 1996;31:215-22 pubmed
    ..We also independently identified the BAT1 gene to be the well-conserved homologue of a previously described rat liver nuclear protein. ..
  5. Pende D, Parolini S, Pessino A, Sivori S, Augugliaro R, Morelli L, et al. Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. J Exp Med. 1999;190:1505-16 pubmed
    ..In this study, by the generation of monoclonal antibodies (mAbs), we identified NKp30, a novel 30-kD triggering receptor selectively expressed by all resting and activated human natural killer (NK) ..
  6. Mavoungou E, Held J, Mewono L, Kremsner P. A Duffy binding-like domain is involved in the NKp30-mediated recognition of Plasmodium falciparum-parasitized erythrocytes by natural killer cells. J Infect Dis. 2007;195:1521-31 pubmed
    ..We showed that with NKp30-immunoglobulin and NKp46-immunoglobulin fusion proteins and DBL-1alpha peptides NCRs are involved in the NK cell-..
  7. Byrd A, Hoffmann S, Jarahian M, Momburg F, Watzl C. Expression analysis of the ligands for the Natural Killer cell receptors NKp30 and NKp44. PLoS ONE. 2007;2:e1339 pubmed
    ..Here we analyze the expression of NKp30 ligand and NKp44 ligand on 30 transformed or non-transformed cell lines of different origin...
  8. Simhadri V, Reiners K, Hansen H, Topolar D, Simhadri V, Nohroudi K, et al. Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function. PLoS ONE. 2008;3:e3377 pubmed publisher
    b>NKp30, a natural cytotoxicity receptor expressed on NK cells is critically involved in direct cytotoxicity against various tumor cells and directs both maturation and selective killing of dendritic cells...
  9. Brandt C, Baratin M, Yi E, Kennedy J, Gao Z, Fox B, et al. The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans. J Exp Med. 2009;206:1495-503 pubmed publisher
    ..We report the identification of a tumor cell surface molecule that binds NKp30, a human receptor which triggers antitumor NK cell cytotoxicity and cytokine secretion...

More Information

Publications128 found, 100 shown here

  1. Augugliaro R, Parolini S, Castriconi R, Marcenaro E, Cantoni C, Nanni M, et al. Selective cross-talk among natural cytotoxicity receptors in human natural killer cells. Eur J Immunol. 2003;33:1235-41 pubmed
    ..These receptors include NKp46, NKp30 and NKp44, collectively termed natural cytotoxicity receptors (NCR)...
  2. Vitale M, Della Chiesa M, Carlomagno S, Pende D, Arico M, Moretta L, et al. NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor. Blood. 2005;106:566-71 pubmed
    ..While killing of immature DCs is dependent on the function of the NKp30 triggering receptor, the mechanism by which NK cells induce DC maturation is still unclear...
  3. Warren H, Jones A, Freeman C, Bettadapura J, Parish C. Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan. J Immunol. 2005;175:207-12 pubmed
    NKp30 (NCR3, CD337) is a natural cytotoxicity receptor, expressed on subsets of human peripheral blood NK cells, involved in NK cell killing of tumor cells and immature dendritic cells...
  4. Amid B, Mirhosseini H, Kostadinović S. Chemical composition and molecular structure of polysaccharide-protein biopolymer from Durio zibethinus seed: extraction and purification process. Chem Cent J. 2012;6:117 pubmed publisher
    ..A size-exclusion chromatography coupled to multi angle laser light-scattering (SEC-MALS) was applied to analyze the molecular weight (Mw), number average molecular weight (Mn), and polydispersity index (..
  5. Sharma N, Chakravarthy S, Longley M, Copeland W, Prakash A. The C-terminal tail of the NEIL1 DNA glycosylase interacts with the human mitochondrial single-stranded DNA binding protein. DNA Repair (Amst). 2018;65:11-19 pubmed publisher
    ..in the presence and absence of a partial-duplex DNA substrate using a combination of multi-angle light scattering (MALS) and small-angle X-ray scattering (SAXS)...
  6. Jouini M, Abdelhamid A, Chaouch M, Le Cerf D, Bouraoui A, Majdoub H, et al. Physico-chemical characterization and pharmacological activities of polysaccharides from Opuntia microdasys var. rufida cladodes. Int J Biol Macromol. 2018;107:1330-1338 pubmed publisher
    ..rufida's (OMR) cladodes and to characterize these polysaccharides by size exclusion (SEC/MALS/VD/DRI), gas chromatography coupled to mass spectrometer (GC-MS), nuclear magnetic resonance (1H NMR), ..
  7. Salem Y, Amri S, Hammi K, Abdelhamid A, Cerf D, Bouraoui A, et al. Physico-chemical characterization and pharmacological activities of sulfated polysaccharide from sea urchin, Paracentrotus lividus. Int J Biol Macromol. 2017;97:8-15 pubmed publisher
    ..characterized by size exclusion chromatography coupling on-line with light scattering and viscosity detectors (SEC/MALS/VD/DRI), gas chromatography coupled to mass spectrometer (GC-MS), and Fourier transform infrared spectroscopy (FTIR)..
  8. Takahashi H, Yamamoto T, Yamazaki M, Murase T, Matsuno T, Chishima F. Natural Cytotoxicity Receptors in Decidua Natural Killer Cells of Term Normal Pregnancy. J Pregnancy. 2018;2018:4382084 pubmed publisher
    ..and Per-CP anti-CD3 monoclonal antibodies, and the NCRs were stained with PE-conjugated anti-NKG2D, NKp46, NKp30, and NKp44 monoclonal antibodies...
  9. Prasad Y, Kumar R, Chaudhary A, Dhanaraju R, Majumdar S, Rao D. Kinetic and catalytic properties of M.HpyAXVII, a phase-variable DNA methyltransferase from Helicobacter pylori. J Biol Chem. 2019;294:1019-1034 pubmed publisher
    ..Results from size-exclusion chromatography and multi-angle light scattering (MALS) analyses suggested that M.HpyAXVII exists as a dimer in solution...
  10. Jamil K, Hydes T, Cheent K, Cassidy S, Traherne J, Jayaraman J, et al. STAT4-associated natural killer cell tolerance following liver transplantation. Gut. 2017;66:352-361 pubmed publisher
    ..NK cells from non-HCV LT recipients were hypofunctional, with reduced expression of NKp46 (p<0.05) and NKp30 (p<0.001), reduced cytotoxicity (p<0.001) and interferon (IFN)-γ secretion (p<0.025)...
  11. Fu Q, Man X, Yu M, Chu Y, Luan X, Piao H, et al. Human decidua mesenchymal stem cells regulate decidual natural killer cell function via interactions between collagen and leukocyte‑associated immunoglobulin‑like receptor 1. Mol Med Rep. 2017;16:2791-2798 pubmed publisher
    ..The expression of cell surface molecules, natural cytotoxicity triggering receptor 3 and killer cell immunoglobulin‑like receptor (KIR) 2DL1, and the secretion of cytokines, ..
  12. Lauber J, Handrick R, Leptihn S, Dürre P, Gaisser S. Expression of the functional recombinant human glycosyltransferase GalNAcT2 in Escherichia coli. Microb Cell Fact. 2015;14:3 pubmed publisher
    ..and was subsequently analysed by size exclusion chromatography coupled to multi-angle light scattering (SEC-MALS) and circular dichroism spectroscopy to determine molecular mass, folding state and thermal transitions of the ..
  13. Hadj Ammar H, Lajili S, Ben Said R, Le Cerf D, Bouraoui A, Majdoub H. Physico-chemical characterization and pharmacological evaluation of sulfated polysaccharides from three species of Mediterranean brown algae of the genus Cystoseira. Daru. 2015;23:1 pubmed publisher
    ..with a triple detection: multiangle light scattering, viscometer and differential refractive index detectors, (SEC/MALS/VD/DRI)...
  14. Wu M, Zhang T, DeMars L, Sentman C. B7H6-specific chimeric antigen receptors lead to tumor elimination and host antitumor immunity. Gene Ther. 2015;22:675-84 pubmed publisher
    ..In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types...
  15. Klöß S, Oberschmidt O, Morgan M, Dahlke J, Arseniev L, Huppert V, et al. Optimization of Human NK Cell Manufacturing: Fully Automated Separation, Improved Ex Vivo Expansion Using IL-21 with Autologous Feeder Cells, and Generation of Anti-CD123-CAR-Expressing Effector Cells. Hum Gene Ther. 2017;28:897-913 pubmed publisher
    ..Compared to freshly isolated NK cells, expanded NK cells expressed significantly higher levels of NKp30, NKp44, NKG2D, TRAIL, FasL, CD69, and CD137, and showed comparable cell viabilities and killing/degranulation ..
  16. Zhang H, Cui Y, Voong N, Sabatino M, Stroncek D, Morisot S, et al. Activating signals dominate inhibitory signals in CD137L/IL-15 activated natural killer cells. J Immunother. 2011;34:187-95 pubmed publisher
    ..in NKG2D, tumor necrosis factor-related apoptosis-inducing ligand, and natural cytotoxicity receptors (NCRs: NKp30, NKp44, NKp46)...
  17. Francis O, Baker G, Race P, Adams J. Studies of recombinant TWA1 reveal constitutive dimerization. Biosci Rep. 2017;37: pubmed publisher
    ..Gel filtration chromatography, size-exclusion chromatography (SEC) with multi-angle light scattering (SEC-MALS) and native PAGE demonstrated a propensity of untagged TWA1 to form stable dimers and, to a lesser extent, higher ..
  18. Lueckheide M, Vieregg J, Bologna A, Leon L, Tirrell M. Structure-Property Relationships of Oligonucleotide Polyelectrolyte Complex Micelles. Nano Lett. 2018;18:7111-7117 pubmed publisher
    ..a multimodal characterization strategy combining small-angle X-ray scattering (SAXS), multiangle light scattering (MALS), and cryo-electron microscopy (cryo-TEM) to simultaneously probe the morphology and internal structure of the ..
  19. Schmiedel D, Tai J, Levi Schaffer F, Dovrat S, Mandelboim O. Human Herpesvirus 6B Downregulates Expression of Activating Ligands during Lytic Infection To Escape Elimination by Natural Killer Cells. J Virol. 2016;90:9608-9617 pubmed publisher
    ..two powerful activating NK cell receptors: ULBP1, ULBP3, and MICB, which trigger NKG2D, and B7-H6, which activates NKp30. Accordingly, this downregulation impaired the ability of NK cells to recognize HHV-6-infected cells...
  20. Günther S, Ostheimer C, Stangl S, Specht H, Mózes P, Jesinghaus M, et al. Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer. Front Immunol. 2015;6:556 pubmed publisher
    ..C-type lectin receptors, such as CD94/NKG2C, NKG2D, and natural cytotoxicity receptors (NCRs; NKp44, NKp46, and NKp30) and thereby gain the capacity to kill mHsp70-positive tumor cells...
  21. Altiok E, Santiago Ortiz J, Svedlund F, Zbinden A, Jha A, Bhatnagar D, et al. Multivalent hyaluronic acid bioconjugates improve sFlt-1 activity in vitro. Biomaterials. 2016;93:95-105 pubmed publisher
    ..Using size exclusion chromatography with multiangle light scattering (SEC-MALS), SDS-PAGE, and dynamic light scattering (DLS), we characterized the mvsFlt with a focus on the molecular weight ..
  22. Yao J, Ly D, Dervovic D, Fang L, Lee J, Kang H, et al. Human double negative T cells target lung cancer via ligand-dependent mechanisms that can be enhanced by IL-15. J Immunother Cancer. 2019;7:17 pubmed publisher
    ..Expanded DNTs have a cytotoxic phenotype, as they express NKp30, NKG2D, DNAM-1, membrane TRAIL (mTRAIL), perforin and granzyme B, and secrete IFNγ and soluble TRAIL (sTRAIL)...
  23. Ferrari de Andrade L, Ngiow S, Stannard K, Rusakiewicz S, Kalimutho M, Khanna K, et al. Natural killer cells are essential for the ability of BRAF inhibitors to control BRAFV600E-mutant metastatic melanoma. Cancer Res. 2014;74:7298-308 pubmed publisher
    ..PLX4720 also increased human NK cell pERK1/2, CD69 expression, and IFNγ release in the context of anti-NKp30 and IL2 stimulation...
  24. Xue Q, Qi Y, Liu F. Ultra-high performance liquid chromatography-electrospray tandem mass spectrometry for the analysis of antibiotic residues in environmental waters. Environ Sci Pollut Res Int. 2015;22:16857-67 pubmed publisher
    ..analysis of 35 antibiotics including sulfonamides (SAs), quinolones (QLs), tetracyclines (TCs), macrolides (MALs), lincomycin (LIN), and chloramphenicol (CAP). The addition of 0...
  25. Han R, Wu W, Wu X, Liu C. Effect of total flavonoids from the seeds of Astragali complanati on natural killer cell function. J Ethnopharmacol. 2015;173:157-65 pubmed publisher
    ..To explore the mechanism of action, mRNA and protein expressions of activating receptors (NKp30, NKp44, NKp46 and NKG2D) in NK-92 cells were detected by quantitative real-time PCR and flow cytometry analysis...
  26. Tanimine N, Tanaka Y, Abe T, Piao J, Chayama K, Ohdan H. Functional Behavior of NKp46-Positive Intrahepatic Natural Killer Cells Against Hepatitis C Virus Reinfection After Liver Transplantation. Transplantation. 2016;100:355-64 pubmed publisher
    ..Huh7-HCV replicon system, anti-HCV activity was induced via recognition of the NK cell receptors, including NKp46, NKp30, and NKG2D, which was demonstrated by the use of monoclonal antibodies that neutralized neutralizing molecules...
  27. Adachi N, Aizawa K, Kratzer Y, Saijo S, Shimizu N, Senda T. Improved method for soluble expression and rapid purification of yeast TFIIA. Protein Expr Purif. 2017;133:50-56 pubmed publisher
    ..TFIIA's heterodimer formation was confirmed by size exclusion chromatography-multiangle light scattering (SEC-MALS)...
  28. Roberto A, Di Vito C, Zaghi E, Mazza E, Capucetti A, Calvi M, et al. The early expansion of anergic NKG2Apos/CD56dim/CD16neg natural killer represents a therapeutic target in haploidentical hematopoietic stem cell transplantation. Haematologica. 2018;103:1390-1402 pubmed publisher
    ..hematopoietic stem cell transplantation, and express high levels of the activating receptors NKG2D and NKp30 as well as of the lytic granules Granzyme-B and Perforin...
  29. Marafini I, Monteleone I, Di Fusco D, Sedda S, Cupi M, Fina D, et al. Celiac Disease-Related Inflammation Is Marked by Reduction of Nkp44/Nkp46-Double Positive Natural Killer Cells. PLoS ONE. 2016;11:e0155103 pubmed publisher
    ..In active CD, the fractions of NKp30+ NK cells, NKG2D+ NK cells and NKG2D+ NKT cells were significantly increased as compared to inactive CD patients ..
  30. Mueller Leisse J, Brueggemann S, Bouzani M, Schmitt A, Einsele H, Loeffler J. Polymorphonuclear neutrophils and granulocytic myeloid-derived suppressor cells inhibit natural killer cell activity toward Aspergillus fumigatus. Med Mycol. 2015;53:622-9 pubmed publisher
    ..Both cell types exhibited an equal inhibitory effect on NK cell activation through downregulation of NKp30 expression on the cell surface and cytotoxicity towards the cell line K562...
  31. Terra Junior O, Maldonado G, Alfradique G, Lisboa V, Arnobio A, de Lima D, et al. Study of Natural Cytotoxicity Receptors in Patients with HIV/AIDS and Cancer: A Cross-Sectional Study. ScientificWorldJournal. 2016;2016:2085871 pubmed publisher
    ..We found a significant decrease in the frequency of NK cells expressing NKp30 in the HIV/AIDS group (p = 0.0144)...
  32. Kress C, Sadowski G, Brandenbusch C. Solubilization of proteins in aqueous two-phase extraction through combinations of phase-formers and displacement agents. Eur J Pharm Biopharm. 2017;112:38-44 pubmed publisher
    ..on the IgG-IgG interactions was determined using composition gradient multi-angle light scattering (CG-MALS) demonstrating that NaCl induces a solubilization of IgG in polyethylene glycol 2000 solution...
  33. Kim J, Chang D, Lee H, Lee H, Kim J, Sung P, et al. Innate-like Cytotoxic Function of Bystander-Activated CD8+ T Cells Is Associated with Liver Injury in Acute Hepatitis A. Immunity. 2018;48:161-173.e5 pubmed publisher
    ..T cells derived from AHA patients exerted innate-like cytotoxicity triggered by activating receptors NKG2D and NKp30 without TCR engagement...
  34. Mulcahy H, O Rourke K, Adams C, Molloy M, O Gara F. LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection. Immunogenetics. 2006;57:893-903 pubmed
    ..in the MHC class IV region, leucocyte-specific transcript (LST) 1 and natural cytotoxicity-triggering receptor 3 (NCR3) (also known as 1C7 and natural killer (NK)p30)...
  35. Varchetta S, Oliviero B, Mavilio D, Mondelli M. Different combinations of cytokines and activating receptor stimuli are required for human natural killer cell functional diversity. Cytokine. 2013;62:58-63 pubmed publisher
    ..Cytokine stimulation combined with NK receptor engagement can be helpful in the dissection of NK cell responses in health and disease. ..
  36. Romero M, Alcaraz Á, Saleg P, Roussy Otero G, Moser F, Eynard H. [Celiac trunk compression syndrome by the median arcuate ligament. Laparoscopic approach]. Medicina (B Aires). 2015;75:169-72 pubmed
    Median arcuate ligament syndrome (MALS), or celiac trunk compression syndrome, is caused by extrinsic compression of median arcuate ligament, prominent fibrous bands and periaortic nodal tissue...
  37. Verstrepen B, Nieuwenhuis I, Mooij P, Bogers W, Boonstra A, Koopman G. Spontaneous and natural cytotoxicity receptor-mediated cytotoxicity are effector functions of distinct natural killer subsets in hepatitis C virus-infected chimpanzees. Clin Exp Immunol. 2016;185:42-9 pubmed publisher
    ..By contrast, increased natural cytotoxicity receptor (NCR)- mediated degranulation after NKp30 and NKp44 triggering was demonstrated in the CD94(dim) CD16(neg) subset...
  38. Hervier B, Perez M, Allenbach Y, Devilliers H, Cohen F, Uzunhan Y, et al. Involvement of NK Cells and NKp30 Pathway in Antisynthetase Syndrome. J Immunol. 2016;197:1621-30 pubmed publisher
    ..002) compared with controls. Importantly, active aSS was more specifically associated with a significant NKp30 decrease (p = 0.009), although levels of mRNA and intracellular protein were similar in aSS and healthy controls...
  39. Choi I, Yoon S, Park S, Kim H, Jung S, Kang Y, et al. Donor-Derived Natural Killer Cell Infusion after Human Leukocyte Antigen-Haploidentical Hematopoietic Cell Transplantation in Patients with Refractory Acute Leukemia. Biol Blood Marrow Transplant. 2016;22:2065-2076 pubmed publisher
    ..refractory acute leukemia who underwent haploidentical HCT and DNKI on days 14 and 21 only, higher expression of NKp30 (>90%) on donor NK cells was an independent predictor of higher complete remission (hazard ratio, 5...
  40. Tran H, Wan Z, Sheard M, Sun J, Jackson J, Malvar J, et al. TGFβR1 Blockade with Galunisertib (LY2157299) Enhances Anti-Neuroblastoma Activity of the Anti-GD2 Antibody Dinutuximab (ch14.18) with Natural Killer Cells. Clin Cancer Res. 2017;23:804-813 pubmed publisher
    ..with exogenous TGFβ1, galunisertib suppressed SMAD2 phosphorylation and restored the expression of DNAM-1, NKp30, and NKG2D cytotoxicity receptors and the TRAIL death ligand, the release of perforin and granzyme A, and the ..
  41. Gruia F, Parupudi A, Polozova A. Practical Considerations for Detection and Characterization of Sub-Micron Particles in Protein Solutions by Nanoparticle Tracking Analysis. PDA J Pharm Sci Technol. 2015;69:427-39 pubmed publisher
    ..NTA was compared against asymmetric flow field flow fractionation coupled with multi-angle light scattering (aF4-MALS) and dynamic light scattering, which are other techniques for sub-micron particles...
  42. Rogstad S, Pang E, Sommers C, Hu M, Jiang X, Keire D, et al. Modern analytics for synthetically derived complex drug substances: NMR, AFFF-MALS, and MS tests for glatiramer acetate. Anal Bioanal Chem. 2015;407:8647-59 pubmed publisher
    ..and 2D NMR), and asymmetric field flow fractionation (AFFF) coupled with multi-angle light scattering (MALS) for an in-depth characterization of three lots of the marketplace drug and a formulated sample of the comparator...
  43. Liu F, Duan X, Wan Z, Zang H, You S, Yang R, et al. Lower number and decreased function of natural killer cells in hepatitis B virus related acute-on-chronic liver failure. Clin Res Hepatol Gastroenterol. 2016;40:605-613 pubmed publisher
    ..The activating receptors of NKG2D, NKp30, NKp44, and NKp46 were increased in patients with ACLF...
  44. Zielke C, Teixeira C, Ding H, Cui S, Nyman M, Nilsson L. Analysis of ?-glucan molar mass from barley malt and brewer's spent grain with asymmetric flow field-flow fractionation (AF4) and their association to proteins. Carbohydr Polym. 2017;157:541-549 pubmed publisher
    ..distribution was assessed using asymmetric flow field-flow fractionation (AF4) with multiangle light scattering (MALS), differential refractive index (dRI) and fluorescence (FL) detection...
  45. Halgasova N, Solteszova B, Pevala V, Košťan J, Kutejová E, Bukovska G. A RepA-like protein from bacteriophage BFK20 is a multifunctional protein with primase, polymerase, NTPase and helicase activities. Virus Res. 2015;210:178-87 pubmed publisher
    ..A SEC-MALS analysis indicated that gp43-1 forms a hexameric homooligomer...
  46. Yeo K, Park J, Kim E, Jeon Y, Hwang K, Cheong H. Characterization of the sensor domain of QseE histidine kinase from Escherichia coli. Protein Expr Purif. 2016;126:122-126 pubmed publisher
    ..Thereafter, the characteristics of the refolded protein were determined from NMR, CD, and MALS spectroscopies. In a pH range of 7.4-5...
  47. Egidi E, Wood J, Aracic S, Kannan R, McDonald L, Bell C, et al. Draft Genome Sequence of Enterobacter ludwigii NCR3, a Heavy Metal-Resistant Rhizobacterium. Genome Announc. 2016;4: pubmed publisher
    We report here the draft genome of Enterobacter ludwigii NCR3, a Gram-negative bacterium isolated from the Carpobrotus rossii (Haw.) Schwantes rhizosphere. The analysis of the ~4...
  48. Choi J, Zielke C, Nilsson L, Lee S. Characterization of the molar mass distribution of macromolecules in beer for different mashing processes using asymmetric flow field-flow fractionation (AF4) coupled with multiple detectors. Anal Bioanal Chem. 2017;409:4551-4558 pubmed publisher
    ..Asymmetric flow field-flow fractionation (AF4) in combination with ultraviolet (UV), multiangle light scattering (MALS) and differential refractive index (dRI) detectors was used to separate the macromolecules present in the beers and ..
  49. Poggi A, Prevosto C, Massaro A, Negrini S, Urbani S, Pierri I, et al. Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: role of NKp30 and NKG2D receptors. J Immunol. 2005;175:6352-60 pubmed
    ..Furthermore, the NKp30, among natural cytotoxicity receptors, appeared to be primarily involved in triggering NK cells upon interaction ..
  50. Golden Mason L, Cox A, Randall J, Cheng L, Rosen H. Increased natural killer cell cytotoxicity and NKp30 expression protects against hepatitis C virus infection in high-risk individuals and inhibits replication in vitro. Hepatology. 2010;52:1581-9 pubmed publisher
    ..0001). NKp30, a natural cytotoxicity receptor involved in NK activation, is highest on NK/NT cells in EUs relative to infected ..
  51. Zielke C, Kosík O, Ainalem M, Lovegrove A, Stradner A, Nilsson L. Characterization of cereal β-glucan extracts from oat and barley and quantification of proteinaceous matter. PLoS ONE. 2017;12:e0172034 pubmed publisher
    ..mass distributions using asymmetric flow field-flow fractionation (AF4) coupled to multiangle light scattering (MALS), differential refractive index (dRI) and fluorescence (FL) detection...
  52. Bhattacharya S, Muhammad N, Steele R, Kornbluth J, Ray R. Bitter Melon Enhances Natural Killer-Mediated Toxicity against Head and Neck Cancer Cells. Cancer Prev Res (Phila). 2017;10:337-344 pubmed publisher
    ..3 cells exposed to BME. Furthermore, an increase in cell surface expression of CD16 and NKp30 in BME-treated NK3.3 cells was observed when cocultured with HNSCC cells...
  53. Song W, Zhang Y, Gao Y, Chen D, Yang M. Cleavage of the main carbon chain backbone of high molecular weight polyacrylamide by aerobic and anaerobic biological treatment. Chemosphere. 2017;189:277-283 pubmed publisher
    ..In this study, viscometry, flow field-flow fractionation multi-angle light scattering (FFF-MALS), and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) analysis were used to investigate the ..
  54. Kellner C, Maurer T, Hallack D, Repp R, van de Winkel J, Parren P, et al. Mimicking an induced self phenotype by coating lymphomas with the NKp30 ligand B7-H6 promotes NK cell cytotoxicity. J Immunol. 2012;189:5037-46 pubmed publisher
    Induced self expression of the NKp30 ligand B7-H6 facilitates NK cell-mediated elimination of stressed cells...
  55. Miranda Hernández M, Valle González E, Ferreira Gómez D, Pérez N, Flores Ortiz L, Medina Rivero E. Theoretical approximations and experimental extinction coefficients of biopharmaceuticals. Anal Bioanal Chem. 2016;408:1523-30 pubmed publisher
    ..liquid chromatograph coupled to an ultraviolet, multiangle light scattering and refractive index (SE-UPLC-UV-MALS-RI) multidetection system...
  56. Eichmann C, Campioni S, Kowal J, Maslennikov I, Gerez J, Liu X, et al. Preparation and Characterization of Stable α-Synuclein Lipoprotein Particles. J Biol Chem. 2016;291:8516-27 pubmed publisher
    ..Chemical cross-linking in combination with solution-state NMR and multiangle static light scattering (MALS) of α-Syn particles reveal a high-order protein-lipid entity composed of ∼8-10 α-Syn molecules...
  57. Upadhyay V, Ceh K, Tumulka F, Abele R, Hoffmann J, Langer J, et al. Molecular characterization of methanogenic N(5)-methyl-tetrahydromethanopterin: Coenzyme M methyltransferase. Biochim Biophys Acta. 2016;1858:2140-2144 pubmed publisher
    ..mass spectrometry (LILBID-MS) and size exclusion chromatography coupled with multi-angle light scattering (SEC-MALS) resulted in a (MtrABCDEFG)3 heterotrimeric complex of ca. 430kDa with both techniques...
  58. Yang C, Yoon J, Park J, Lee J. Hepatitis C virus impairs natural killer cell activity via viral serine protease NS3. PLoS ONE. 2017;12:e0175793 pubmed publisher
    ..Consistent with these findings, the expression levels of activating NK cell receptors, such as NKp46 and NKp30, were also increased...
  59. Mukherjee A, Hackley V. Separation and characterization of cellulose nanocrystals by multi-detector asymmetrical-flow field-flow fractionation. Analyst. 2018;143:731-740 pubmed publisher
    ..based on asymmetrical-flow field-flow fractionation (AF4) coupled with on-line multi-angle light scattering (MALS), dynamic light scattering (DLS), and differential refractometry (dRI)...
  60. Sivakamasundari R, Raghunathan A, Zhang C, Chowdhury R, Weissman S. Expression and cellular localization of the protein encoded by the 1C7 gene: a recently described component of the MHC. Immunogenetics. 2000;51:723-32 pubmed
    ..a cluster of genes designated as MHC class IV encoding genes involved in immunity and inflammation, including the 1C7 gene...
  61. Yang H, Tang R, Li J, Liu Y, Ye L, Shao D, et al. A New Ex Vivo Method for Effective Expansion and Activation of Human Natural Killer Cells for Anti-Tumor Immunotherapy. Cell Biochem Biophys. 2015;73:723-9 pubmed publisher
    ..The positive expression rates for the activating receptors NKG2D, CD94, NKp46, NKp30, and NKp44 of healthy human NK cells expanded ex vivo were increased by 60, 40, 20, 40, and 63 %, respectively, ..
  62. Chen K, Long D, Lute S, Levy M, Brorson K, Keire D. Simple NMR methods for evaluating higher order structures of monoclonal antibody therapeutics with quinary structure. J Pharm Biomed Anal. 2016;128:398-407 pubmed publisher
    ..e., size-exclusion-chromatography (SEC) FPLC, multi-angle light scattering (MALS), circular dichroism (CD), NMR and multivariate analysis, were combined and modified to yield a complete profile of ..
  63. Ho K, Walker P, Smithers B, Foster W, Nathanson L, O Rourke N, et al. Outcome predictors in median arcuate ligament syndrome. J Vasc Surg. 2017;65:1745-1752 pubmed publisher
    Median arcuate ligament syndrome (MALS) is a condition characterized by chronic abdominal symptoms associated with median arcuate ligament compression of the celiac artery. The selection of patients is difficult in the management of MALS...
  64. Grant Y, Onida S, Dharmarajah B, Davies E, Davies A. Exercise induced median arcuate ligament syndrome in athletes: case series. J Sports Med Phys Fitness. 2017;: pubmed publisher
    ..leading to mechanical compression of the coeliac artery, resulting in the clinical condition of MAL syndrome (MALS)...
  65. Barnett G, Perhacs J, Das T, Kar S. Submicron Protein Particle Characterization using Resistive Pulse Sensing and Conventional Light Scattering Based Approaches. Pharm Res. 2018;35:58 pubmed publisher
    ..sensing, dynamic light scattering and size-exclusion chromatography with in-line multi-angle light scattering (SEC-MALS) are performed on protein and placebo formulations, polystyrene size standards, placebo formulations spiked with ..
  66. Zhou Y, Xu Y, Chen L, Xu B, Wu C, Jiang J. B7-H6 expression correlates with cancer progression and patient's survival in human ovarian cancer. Int J Clin Exp Pathol. 2015;8:9428-33 pubmed
    B7-H6, a newly identified B7 family member molecule, binds to its receptor on NK cells, NKp30, and then triggers the anti-tumor NK cell cytotoxicity and leads to the cytokine secretion...
  67. Sadallah S, Schmied L, Eken C, Charoudeh H, Amicarella F, Schifferli J. Platelet-Derived Ectosomes Reduce NK Cell Function. J Immunol. 2016;197:1663-71 pubmed publisher
    ..We found a reduced expression of several activating surface receptors (NKG2D, NKp30, and DNAM-1) and decreased NK cell function, as measured by CD107a expression and IFN-? production...
  68. Xu X, Narni Mancinelli E, Cantoni C, Li Y, Guia S, Gauthier L, et al. Structural Insights into the Inhibitory Mechanism of an Antibody against B7-H6, a Stress-Induced Cellular Ligand for the Natural Killer Cell Receptor NKp30. J Mol Biol. 2016;428:4457-4466 pubmed publisher
    ..3) against human B7-H6, a stress-induced cellular ligand for the natural killer (NK) cell receptor NKp30. Binding of this antibody to B7-H6, a transmembrane protein expressed on tumor and other stressed cells, but not ..
  69. Sun D, Rouse R, Patel V, Wu Y, Zheng J, Karmakar A, et al. Comparative Evaluation of U.S. Brand and Generic Intravenous Sodium Ferric Gluconate Complex in Sucrose Injection: Physicochemical Characterization. Nanomaterials (Basel). 2018;8: pubmed publisher
    ..SV-AUC) and molecular weight by asymmetric field flow fractionation-multi-angle light scattering (AFFF-MALS)...
  70. Poggi A, Massaro A, Negrini S, Contini P, Zocchi M. Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors. J Immunol. 2005;174:2653-60 pubmed
    ..evidence that tumor cells can induce apoptosis of NK cells by engaging the natural cytotoxicity receptors (NCR) NKp30, NKp44, and NKp46...
  71. Merkt W, Urlaub D, Meinke S, Kammerer R, Watzl C. Inhibition of NKp30- and 2B4-mediated NK cell activation by evolutionary different human and bovine CEACAM1 receptors. Eur J Immunol. 2015;45:2134-42 pubmed publisher
    ..We show that in addition to NKG2D, human CEACAM1 can inhibit NK-cell activation via NKp30 or 2B4. Bovine CEACAM1, possessing an ITIM and an ITSM signaling motif, is also inhibitory...
  72. Salimi M, Xue L, Jolin H, Hardman C, Cousins D, McKenzie A, et al. Group 2 Innate Lymphoid Cells Express Functional NKp30 Receptor Inducing Type 2 Cytokine Production. J Immunol. 2016;196:45-54 pubmed publisher
    ..Therefore, we sought to investigate the expression and functional properties of the natural cytotoxicity receptor NKp30 on human ILC2...
  73. Sogne V, Meier F, Klein T, Contado C. Investigation of zinc oxide particles in cosmetic products by means of centrifugal and asymmetrical flow field-flow fractionation. J Chromatogr A. 2017;1515:196-208 pubmed publisher
    ..and Asymmetrical Flow Field-Flow Fractionation techniques (CF3 and AF4, respectively), equipped with UV-vis, MALS and DLS detectors, in size sorting ZnO particles, both as pristine powders and after their extraction from cosmetic ..
  74. Ponnampalam A, Gargett C, Rogers P. Identification and hormonal regulation of a novel form of NKp30 in human endometrial epithelium. Eur J Immunol. 2008;38:216-26 pubmed
    This study reports the discovery and steroid hormonal regulation of a novel glycosylated form of NKp30 in human endometrial epithelium...
  75. da Silva R, Petta C, Derchain S, Alici E, Guimarães F. Up-regulation of DNAM-1 and NKp30, associated with improvement of NK cells activation after long-term culture of mononuclear cells from patients with ovarian neoplasia. Hum Immunol. 2014;75:777-84 pubmed publisher
    ..As a conclusion, the long-term culture system employed, resulted in a high number of functional NK cells. The culture system was particularly efficient on the up-regulation of NKp30 and DNAM-1 receptors on NK cells.
  76. Kearney C, Vervoort S, Ramsbottom K, Freeman A, Michie J, Peake J, et al. DOCK8 Drives Src-Dependent NK Cell Effector Function. J Immunol. 2017;: pubmed publisher
    ..through inhibition of Src family kinase activation, particularly Lck, downstream of target cell engagement or NKp30 ligation...
  77. Zielke C, Fuentes C, Piculell L, Nilsson L. Co-elution phenomena in polymer mixtures studied by asymmetric flow field-flow fractionation. J Chromatogr A. 2018;1532:251-256 pubmed publisher
    ..Only few analytical techniques are suitable for the task. AF4-MALS-dRI is highly suited for the task, but the analysis can nevertheless be especially challenging for heterogeneous ..
  78. Ouyang Y, Zeng Y, Yi L, Tang H, Li D, Linhardt R, et al. Qualitative and quantitative analysis of heparin and low molecular weight heparins using size exclusion chromatography with multiple angle laser scattering/refractive index and inductively coupled plasma/mass spectrometry detectors. J Chromatogr A. 2017;1522:56-61 pubmed publisher
    ..Size exclusion chromatography (SEC), relying on multiple angle laser scattering (MALS)/refractive index (RI) detectors, has been developed for accurate analysis of heparin MW in the absence of ..
  79. Valdes A, Thomson G. Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. Diabetes Obes Metab. 2009;11 Suppl 1:46-52 pubmed publisher
    ..Our data confirm that the class III region is involved in T1D susceptibility and suggest that more than one gene in the region is involved. ..
  80. Matta J, Baratin M, Chiche L, Forel J, Cognet C, Thomas G, et al. Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions. Blood. 2013;122:394-404 pubmed publisher
    B7-H6, a member of the B7 family of immunoreceptors, is as a cell-surface ligand for the NKp30-activating receptor expressed on natural killer cells...
  81. Mantovani S, Mele D, Oliviero B, Barbarini G, Varchetta S, Mondelli M. NKp30 isoforms in patients with chronic hepatitis C virus infection. Immunology. 2015;146:234-42 pubmed publisher
    ..The NKp30 activating receptor and its isoforms have recently emerged as important determinants of efficient NK cell ..
  82. Liu H, Li Y, Shi A, Hu H, Sheng X, Liu L, et al. Rheological characteristics and chain conformation of mannans obtained from Saccharomyces cerevisiae. Int J Biol Macromol. 2018;107:2404-2411 pubmed publisher
    ..The conformational parameters of yeast mannans were determined by SEC-MALS-RI-DP. The Higiro's 1 and Higiro's 2 plots were obtained by capillary viscometry gave an intrinsic viscosity of 0...
  83. Boyiadzis M, Memon S, Carson J, Allen K, Szczepanski M, Vance B, et al. Up-regulation of NK cell activating receptors following allogeneic hematopoietic stem cell transplantation under a lymphodepleting reduced intensity regimen is associated with elevated IL-15 levels. Biol Blood Marrow Transplant. 2008;14:290-300 pubmed publisher
    ..Furthermore, in NK cells cultured with IL-15, we observed an up-regulation of the activating receptors NKG2D, NKp30, and NKp46, associated with an increase in anti-tumor lytic activity...
  84. Rojas J, Fernandez I, Pastor J, Garcia Gutierrez M, Sanabria M, Brion M, et al. A strong genetic association between the tumor necrosis factor locus and proliferative vitreoretinopathy: the retina 4 project. Ophthalmology. 2010;117:2417-2423.e1-2 pubmed publisher
    ..were analyzed: lymphotoxin alpha (LTA), TNF?, leukocyte-specific transcript 1 (LST1), and the activating natural killer receptor p30 (NCR3)...
  85. Pham B, Piard Ruster K, Silva R, Gallo A, Esquivel C, Martinez O, et al. Changes in natural killer cell subsets in pediatric liver transplant recipients. Pediatr Transplant. 2012;16:176-82 pubmed publisher
    ..PBMCs were isolated and analyzed for the levels of NK cell activation receptors NKp30, NKp46, and NKG2D in the CD56(dim) CD16(+) and CD56(bright) CD16(+/-) subsets of NK cells...
  86. Binici J, Hartmann J, Herrmann J, Schreiber C, Beyer S, Güler G, et al. A soluble fragment of the tumor antigen BCL2-associated athanogene 6 (BAG-6) is essential and sufficient for inhibition of NKp30 receptor-dependent cytotoxicity of natural killer cells. J Biol Chem. 2013;288:34295-303 pubmed publisher
    Immunosurveillance of tumor cells depends on NKp30, a major activating receptor of human natural killer (NK) cells. The human BCL2-associated athanogene 6 (BAG-6, also known as BAT3; 1126 amino acids) is a cellular ligand of NKp30...
  87. Deme J, Hancock M, Xia X, Shintre C, Plesa M, Kim J, et al. Purification and interaction analyses of two human lysosomal vitamin B12 transporters: LMBD1 and ABCD4. Mol Membr Biol. 2014;31:250-61 pubmed publisher
    ..native PAGE, chemical crosslinking, and size exclusion chromatography coupled to multi-angle light scattering (SEC-MALS), we show that both detergent-solubilized LMBD1 and detergent-solubilized ABCD4 form homodimers...
  88. Wang H, Zheng X, Wei H, Tian Z, Sun R. Important role for NKp30 in synapse formation and activation of NK cells. Immunol Invest. 2012;41:367-81 pubmed publisher
    ..In this study, NKp30-mediated signaling and the role of NKp30 in the formation of the NKIS were investigated...
  89. Memmer S, Weil S, Beyer S, Zöller T, Peters E, Hartmann J, et al. The Stalk Domain of NKp30 Contributes to Ligand Binding and Signaling of a Preassembled NKp30-CD3? Complex. J Biol Chem. 2016;291:25427-25438 pubmed
    The natural cytotoxicity receptor (NCR) NKp30 (CD337) is a key player for NK cell immunosurveillance of infections and cancer. The molecular details of ligand recognition and its connection to CD3? signaling remain unsolved...
  90. Charpak Amikam Y, Kubsch T, Seidel E, Oiknine Djian E, Cavaletto N, Yamin R, et al. Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20. Sci Rep. 2017;7:8661 pubmed publisher
    ..Killing by NK cells is mediated by a small family of activating receptors such as NKp30 that interact with the cellular ligand B7-H6...
  91. Marras F, Casabianca A, Bozzano F, Ascierto M, Orlandi C, Di Biagio A, et al. Control of the HIV-1 DNA Reservoir Is Associated In Vivo and In Vitro with NKp46/NKp30 (CD335 CD337) Inducibility and Interferon Gamma Production by Transcriptionally Unique NK Cells. J Virol. 2017;91: pubmed publisher
    ..Induced interferon gamma (IFN-?) production and NKp46/NKp30 activating receptor-induced expression correlated inversely with reservoir size...
  92. Lajoie L, Congy Jolivet N, Bolzec A, Thibault G. Gradual Increase of Fc?RIIIa/CD16a Expression and Shift toward IFN-? Secretion during Differentiation of CD56dim Natural Killer Cells. Front Immunol. 2017;8:1556 pubmed publisher
    ..Similar results were observed after engagement of ARs by a combination of mAbs targeting NKG2D, NKp30, NKp46, and 2B4...