Gene Symbol: NCOA6
Description: nuclear receptor coactivator 6
Alias: AIB3, ASC2, NRC, PRIP, RAP250, TRBP, nuclear receptor coactivator 6, NRC RAP250, PPAR-interacting protein, activating signal cointegrator-2, amplified in breast cancer protein 3, amplified in breast cancer-3 protein, cancer-amplified transcriptional coactivator ASC-2, nuclear receptor coactivator RAP250, nuclear receptor-activating protein, 250 kDa, peroxisome proliferator-activated receptor interacting protein, thyroid hormone receptor binding protein
Species: human
Products:     NCOA6

Top Publications

  1. Mahajan M, Samuels H. A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein. Mol Cell Biol. 2000;20:5048-63 pubmed
    ..Human NRC (hNRC) harbors a potent N-terminal activation domain (AD1), which is as active as the herpesvirus VP16 activation ..
  2. Lee J, Saha P, Yang Q, Lee S, Park J, Suh Y, et al. Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proc Natl Acad Sci U S A. 2008;105:19229-34 pubmed publisher
    ..These results suggest that ASCOM-MLL3 and ASCOM-MLL4 likely function as crucial but redundant H3K4MT complexes for PPARgamma-dependent adipogenesis. ..
  3. Kim S, Park K, Kwak E, Choi E, Lee S, Ham J, et al. Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice. Mol Cell Biol. 2003;23:3583-92 pubmed
    b>Activating signal cointegrator 2 (ASC-2), a cancer-amplified transcriptional coactivator of nuclear receptors and many other transcription factors, contains two LXXLL-type nuclear receptor interaction domains...
  4. Iwasaki T, Chin W, Ko L. Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). J Biol Chem. 2001;276:33375-83 pubmed
    We previously cloned and characterized thyroid hormone receptor-binding protein (TRBP) as an LXXLL-containing general coactivator that associates with coactivator complexes through its C terminus...
  5. Guan X, Xu J, Anzick S, Zhang H, Trent J, Meltzer P. Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer. Cancer Res. 1996;56:3446-50 pubmed
    ..Using this strategy, we have isolated three novel amplified genes (termed AIB1, AIB3, and AIB4) from a cDNA library constructed from the 20q amplified breast cancer cell line BT-474...
  6. Lee S, Anzick S, Choi J, Bubendorf L, Guan X, Jung Y, et al. A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. J Biol Chem. 1999;274:34283-93 pubmed
    ..From these results, we concluded that ASC-2 is a bona fide transcription coactivator molecule of nuclear receptors, and its altered expression may contribute to the development of cancers. ..
  7. Tang Z, Chen W, Shimada M, Nguyen U, Kim J, Sun X, et al. SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. Cell. 2013;154:297-310 pubmed publisher
    ..These results establish a mechanism in which SET1C and p300 act cooperatively, through direct interactions and coupled histone modifications, to facilitate the function of p53. ..
  8. Goo Y, Sohn Y, Kim D, Kim S, Kang M, Jung D, et al. Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. Mol Cell Biol. 2003;23:140-9 pubmed
    ..These include activating signal cointegrator 2 (ASC-2), a recently isolated transcriptional coactivator molecule, which is amplified in human ..
  9. Caira F, Antonson P, Pelto Huikko M, Treuter E, Gustafsson J. Cloning and characterization of RAP250, a novel nuclear receptor coactivator. J Biol Chem. 2000;275:5308-17 pubmed
    ..The present work describes the cloning and characterization of RAP250, a novel human nuclear receptor coactivator...

More Information


  1. Wang S, Li Y, Song X, Wang X, Zhao C, Chen A, et al. Febuxostat pretreatment attenuates myocardial ischemia/reperfusion injury via mitochondrial apoptosis. J Transl Med. 2015;13:209 pubmed publisher
    ..We utilized an in vivo mouse model of myocardial I/R injury and an in vitro neonatal rat cardiomyocyte (NRC) model of hypoxia/reoxygenation (H/R) injury...
  2. Duan Y, Duan Y, Li F, Li Y, Guo Q, Ji Y, et al. Effects of supplementation with branched-chain amino acids to low-protein diets on expression of genes related to lipid metabolism in skeletal muscle of growing pigs. Amino Acids. 2016;48:2131-44 pubmed publisher
    ..51:0.63 according to the recommendation of the National Research Council (NRC); for diets B to E, the CP level was reduced to 17 %, and the Leu:Ile:Val ratios were 1:1:1, 1:0.75:0.75, 1:0...
  3. Stavang J, Chauvigné F, Kongshaug H, Cerdà J, Nilsen F, Finn R. Phylogenomic and functional analyses of salmon lice aquaporins uncover the molecular diversity of the superfamily in Arthropoda. BMC Genomics. 2015;16:618 pubmed publisher
    ..superfamily can be classified into three major grades (1) classical aquaporins including Big brain (Bib) and Prip-like (PripL) channels (2) aquaglyceroporins (Glp) and (3) unorthodox aquaporins (Aqp12-like)...
  4. Kim G, Park K, Yeom S, Lee K, Kim G, Ko J, et al. Characterization of ASC-2 as an antiatherogenic transcriptional coactivator of liver X receptors in macrophages. Mol Endocrinol. 2009;23:966-74 pubmed publisher
  5. Li X, Hannoufa A, Zhang Y, Yu P. Gene-Silencing-Induced Changes in Carbohydrate Conformation in Relation to Bioenergy Value and Carbohydrate Subfractions in Modeled Plant (Medicago sativa) with Down-Regulation of HB12 and TT8 Transcription Factors. Int J Mol Sci. 2016;17: pubmed publisher
    ..The nutrient bioutilization and bioavailability of the modified forage were determined using NRC-2001 system in terms of total digestive nutrient (TDN), truly digestible fiber (tdNDF), non-fiber carbohydrate (..
  6. Boice J, Ellis E, Golden A, Girardi D, Cohen S, Chen H, et al. The Past Informs the Future: An Overview of the Million Worker Study and the Mallinckrodt Chemical Works Cohort. Health Phys. 2018;114:381-385 pubmed publisher
    ..S. Department of Energy (DOE) Manhattan Project facilities, U.S. Nuclear Regulatory Commission (NRC) regulated nuclear power plants, industrial radiographers, U.S...
  7. Van Ekert E, Chauvigné F, Finn R, Mathew L, Hull J, Cerdà J, et al. Molecular and functional characterization of Bemisia tabaci aquaporins reveals the water channel diversity of hemipteran insects. Insect Biochem Mol Biol. 2016;77:39-51 pubmed publisher
    ..BtAqps), of which seven belong to the classical aquaporin 4-related grade of channels, including Bib, Drip, Prip, and Eglps and one that belongs to the unorthodox grade of aquaporin 12-like channels. B...
  8. Yang L, Piermarini P. Molecular expression of aquaporin mRNAs in the northern house mosquito, Culex pipiens. J Insect Physiol. 2017;96:35-44 pubmed publisher
    ..Aqp12L) were down-regulated and one AQP mRNA (Eglp2) was up-regulated; 3) the expression of two AQP mRNAs (Drip and Prip) were down-regulated and one AQP mRNA (Eglp1) was up regulated after injecting the hemolymph of mosquitoes with PBS;..
  9. Diware M, Cho H, Chegal W, Cho Y, Kim D, O S, et al. Ultrasensitive, label-free detection of cardiac biomarkers with optical SIS sensor. Biosens Bioelectron. 2017;87:242-248 pubmed publisher
    ..label-free, and high-throughput solution immersed silicon (SIS) immunosensor based on non-reflection condition (NRC) for p-polarized wave for early diagnosis of MI...
  10. Froimchuk E, Jang Y, Ge K. Histone H3 lysine 4 methyltransferase KMT2D. Gene. 2017;627:337-342 pubmed publisher
    ..KMT2D associates with WRAD (WDR5, RbBP5, ASH2L, and DPY30), NCOA6, PTIP, PA1, and H3K27 demethylase UTX in one protein complex...
  11. Muangwong A, Boontip T, Pachimsawat J, Napathorn S. Medium chain length polyhydroxyalkanoates consisting primarily of unsaturated 3-hydroxy-5-cis-dodecanoate synthesized by newly isolated bacteria using crude glycerol. Microb Cell Fact. 2016;15:55 pubmed publisher
    ..9% similarity); ASC2, Pseudomonas genus (99.2% similarity); ASC3, Enterobacter genus (99.2% similarity); ASC4, Bacillus genus (98...
  12. Beech R, Leffert J, Lin A, Hong K, Hansen J, Umlauf S, et al. Stress-related alcohol consumption in heavy drinkers correlates with expression of miR-10a, miR-21, and components of the TAR-RNA-binding protein-associated complex. Alcohol Clin Exp Res. 2014;38:2743-53 pubmed publisher
    ..analysis suggested that many of these genes, form part of the transactivation responsive (TAR)-RNA-binding protein (TRBP)-associated complex and are positively regulated by miR-10a and miR-21...
  13. Jankowski J, Tykałowski B, Ognik K, Koncicki A, Kubińska M, Zduńczyk Z. The effect of different dietary levels of DL-methionine and DL-hydroxy analogue on the antioxidant status of young turkeys infected with the haemorrhagic enteritis virus. BMC Vet Res. 2018;14:404 pubmed publisher
    ..Dietary Met content above 40% higher than the level recommended by the NRC (1994) intensified lipid peroxidation in the small intestine, leading to an increase in malondialdehyde (MDA) and ..
  14. Pendse S, Maertens A, Rosenberg M, Roy D, Fasani R, Vantangoli M, et al. Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity. Arch Toxicol. 2017;91:1749-1762 pubmed publisher
    ..for toxicology involves a transition away from high-dose animal studies to in vitro and computational models (NRC in Toxicity testing in the 21st century: a vision and a strategy, The National Academies Press, Washington, DC, ..
  15. Shlyueva D, Meireles Filho A, Pagani M, Stark A. Genome-Wide Ultrabithorax Binding Analysis Reveals Highly Targeted Genomic Loci at Developmental Regulators and a Potential Connection to Polycomb-Mediated Regulation. PLoS ONE. 2016;11:e0161997 pubmed publisher
  16. Chen Y, Mou D, Hu L, Zhen J, Che L, Fang Z, et al. Effects of Maternal Low-Energy Diet during Gestation on Intestinal Morphology, Disaccharidase Activity, and Immune Response to Lipopolysaccharide Challenge in Pig Offspring. Nutrients. 2017;9: pubmed publisher
    ..The nutrient levels of the CON were based on the nutrient recommendations by the National Research Council (NRC, 2012), and contained 3.40 MCal digestible energy (DE)/kg diet and 7.3% crude protein; while the LED contained 3...
  17. Zou T, He D, Yu B, Yu J, Mao X, Zheng P, et al. Moderately increased maternal dietary energy intake delays foetal skeletal muscle differentiation and maturity in pigs. Eur J Nutr. 2016;55:1777-87 pubmed publisher
    ..96 MJ DE/day) as recommended by the National Research Council (NRC; 2012) and high-energy-intake group (HE, 34.15 MJ DE/day)...
  18. Schwarzenberger A, von Elert E. What makes a man a man? Prenatal antennapedia expression is involved in the formation of the male phenotype in Daphnia. Dev Genes Evol. 2016;226:47-51 pubmed publisher
    ..We therefore conclude that differential antp expression is involved in the molecular pathways inducing the male phenotype of Daphnia. ..
  19. Vaughn L, Bragg D, Sharma N, Camargos S, Cardoso F, Patel R. Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT. J Biol Chem. 2015;290:22543-57 pubmed publisher
    ..P222L mutation also changes the affinity of PACT-TRBP interaction after cellular stress, thereby offering a mechanism for the delayed PKR activation in response to ..
  20. Chen J, Zhang F, Guan W, Song H, Tian M, Cheng L, et al. Increasing selenium supply for heat-stressed or actively cooled sows improves piglet preweaning survival, colostrum and milk composition, as well as maternal selenium, antioxidant status and immunoglobulin transfer. J Trace Elem Med Biol. 2019;52:89-99 pubmed publisher
    ..3 vs. 1.2 mg/kg Se as Se-yeast, the basal diet was corn-soybean meal diet formulated according to NRC (2012) except for Se level]...
  21. Li Y, Lu X, Wu H, Xia M, Hou Q, Hu W, et al. The effect of dietary supplementation of low crude protein on intestinal morphology in pigs. Res Vet Sci. 2019;122:15-21 pubmed publisher
    To explore the effects of reducing the Cp levels on intestinal barrier function, low Cp (LP) and NRC standard Cp (NP) diets were fed to pigs from 45 to 160 days, and in vitro experiments were performed using monolayers of IPEC-J2 cells...
  22. Hanson A, Wang L, Johnston L, Baidoo S, Torrison J, Chen C, et al. Effect of feeding peroxidized dried distillers grains with solubles to sows and progeny on growth performance and metabolic oxidative status of nursery pigs. J Anim Sci. 2015;93:135-46 pubmed publisher
    ..1 of 3 nursery diets: 1) corn-soybean meal (CON), 2) 30% peroxidized DDGS (Ox-D), and 3) 30% Ox-D with 5 × NRC (1998) level of VE (Ox-D+5VE) for 7 wk, in a 2 × 3 factorial arrangement of sow and nursery diets (n = 9 pens/..
  23. Lin F, Lin T, Liao C, Chen S. [A Systematic Review and Meta-Analysis of the Pros and Cons of Consuming Liquids Preoperatively]. Hu Li Za Zhi. 2017;64:79-88 pubmed publisher
    ..The authors searched ten databases including NRC (Nursing Reference Center), CINAHL (Cumulative Index to Nursing and Allied Health Literature), WOS (Web of Science),..
  24. Gomes I, Simoes L, Simoes M. The effects of emerging environmental contaminants on Stenotrophomonas maltophilia isolated from drinking water in planktonic and sessile states. Sci Total Environ. 2018;643:1348-1356 pubmed publisher
    ..The simultaneous presence of different ECs in the environment may amplify biofilm resilience. ..
  25. Setton E, Sharma P. Cooption of an appendage-patterning gene cassette in the head segmentation of arachnids. Proc Natl Acad Sci U S A. 2018;115:E3491-E3500 pubmed publisher
  26. Goto S, Lee R, Denlinger D. Aquaporins in the antarctic midge, an extremophile that relies on dehydration for cold survival. Biol Bull. 2015;229:47-57 pubmed
    ..antarctica representing the DRIP, PRIP, BIB, RPIP, and LHIP families...
  27. Perumal P, Savino N, Sangma C, Chang S, Sangtam T, Khan M, et al. Effect of season and age on scrotal circumference, testicular parameters and endocrinological profiles in mithun bulls. Theriogenology. 2017;98:23-29 pubmed publisher
    ..A total of 30 mithun males were selected from the mithun breeding farm, ICAR-NRC on Mithun, Medziphema, Nagaland, India and were equally distributed into five groups based on their age...
  28. Hulbert A, Jusue Torres I, Stark A, Chen C, Rodgers K, Lee B, et al. Early Detection of Lung Cancer Using DNA Promoter Hypermethylation in Plasma and Sputum. Clin Cancer Res. 2017;23:1998-2005 pubmed publisher
    ..b>Conclusions: High diagnostic accuracy for early-stage lung cancer can be obtained using methylated promoter detection in sputum or plasma. Clin Cancer Res; 23(8); 1998-2005. ©2016 AACR. ..
  29. Clemow Y, Manning G, Breton R, Winchell M, Padilla L, Rodney S, et al. A Refined Ecological Risk Assessment for California Red-legged Frog, Delta Smelt and California Tiger Salamander Exposed to Malathion in California. Integr Environ Assess Manag. 2017;: pubmed publisher
    ..ERA was conducted using best available data and approaches, as recommended by the 2013 National Research Council (NRC) report Assessing Risks to Endangered and Threatened Species from Pesticides...
  30. Schmitt S, Mack J, Kienzle E, Alexander L, Morris P, Colyer A, et al. Faecal calcium excretion does not decrease during long-term feeding of a low-calcium diet in adult dogs. J Anim Physiol Anim Nutr (Berl). 2017;: pubmed publisher
    ..In this study we wanted to verify (i) whether a negative calcium balance occurs at a calcium intake equivalent to NRC (2006) (Nutrient requirements of dogs and cats, 2006, The National Academies Press, Washington, DC) minimal ..
  31. Taylor R, Sunde R. Selenium requirements based on muscle and kidney selenoprotein enzyme activity and transcript expression in the turkey poult (Meleagris gallopavo). PLoS ONE. 2017;12:e0189001 pubmed publisher
    The current NRC selenium (Se) requirement for turkeys is 0.2 ?g Se/g diet. We previously fed turkey poults a Se-deficient diet (0.005 ?g Se/g) supplemented with 10 graded levels of Se (0, 0.025, 0.05, 0.1, 0.2, 0.3, 0.4, 0.5, 0.75, 1...
  32. Ko L, Chin W. Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase. J Biol Chem. 2003;278:11471-9 pubmed
    ..We previously cloned and characterized thyroid hormone receptor-binding protein, TRBP (NcoA6: AIB3/ASC-2/RAP250/PRIP/TRBP/NRC), as an LXXLL-containing coactivator that associates with coactivator complexes through its C ..
  33. Qi C, Surapureddi S, Zhu Y, Yu S, Kashireddy P, Rao M, et al. Transcriptional coactivator PRIP, the peroxisome proliferator-activated receptor gamma (PPARgamma)-interacting protein, is required for PPARgamma-mediated adipogenesis. J Biol Chem. 2003;278:25281-4 pubmed
    Nuclear receptor coactivator PRIP (peroxisome proliferators-activated receptor (PPARgamma)-interacting protein) appears to serve as a linker between cAMP response element-binding protein-binding protein (CBP/p300)anchored and PBP (..
  34. Gazdar A, Bunn P, Minna J. Small-cell lung cancer: what we know, what we need to know and the path forward. Nat Rev Cancer. 2017;17:765 pubmed publisher
    This corrects the article DOI: 10.1038/nrc.2017.87.
  35. Joynt R, Seipke R. A phylogenetic and evolutionary analysis of antimycin biosynthesis. Microbiology. 2017;: pubmed publisher
    ..Finally, our findings suggest that the ancestral antimycin producer harboured an L-form gene cluster which was primarily propagated by vertical transmission and subsequently diversified into S-, IQ- and IP-form biosynthetic pathways...
  36. Tang B, Qi G, Sun X, Tang F, Yuan S, Wang Z, et al. HOXA7 plays a critical role in metastasis of liver cancer associated with activation of Snail. Mol Cancer. 2016;15:57 pubmed publisher
    ..Collectively, we identify the critical role and possible mechanism of HOXA7 in metastasis of liver cancer which suggest that HOXA7 may be a potential therapeutic target of liver cancer patients. ..
  37. Kong H, Park M, Hong S, Yu H, Lee Y, Choi Y, et al. Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2. Hepatology. 2003;38:1258-66 pubmed
    ..A recently identified cellular coactivator, activating signal cointegrator 2 (ASC-2), is enriched in liver cancer cells and associates with many transcription factors that are ..
  38. Kong H, Yu H, Hong S, Park M, Choi Y, An W, et al. Interaction and functional cooperation of the cancer-amplified transcriptional coactivator activating signal cointegrator-2 and E2F-1 in cell proliferation. Mol Cancer Res. 2003;1:948-58 pubmed
  39. Jung D, Na S, Na D, Lee J. Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors. J Biol Chem. 2002;277:1229-34 pubmed
    ..Thus, CAPER may represent a more selective transcriptional coactivator molecule that plays a pivotal role for the function of AP-1 and ERs in vivo in conjunction with the general coactivator ASC-2. ..
  40. Zmojdzian M, de Joussineau S, Da Ponte J, Jagla K. Distinct subsets of Eve-positive pericardial cells stabilise cardiac outflow and contribute to Hox gene-triggered heart morphogenesis in Drosophila. Development. 2018;145: pubmed publisher
  41. Burghardt H, Lopez Bermejo A, Baumgartner B, Ibanez L, Vendrell J, Ricart W, et al. The nuclear receptor coactivator AIB3 is a modulator of HOMA beta-cell function in nondiabetic children. Clin Endocrinol (Oxf). 2008;69:730-6 pubmed publisher
    The amplified in breast cancer-3 protein (AIB3) is a nuclear coactivator involved in proliferation, apoptosis and development...
  42. Tants J, Fesser S, Kern T, Stehle R, Geerlof A, Wunderlich C, et al. Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference. Nucleic Acids Res. 2017;45:12536-12550 pubmed publisher
    ..Through genome editing we demonstrate that Loqs-PD, the Drosophila homolog of human TAR RNA binding protein (TRBP) and a paralog of R2D2, forms an alternative RLC with Dcr-2 that is required for strand choice of endogenous siRNAs ..
  43. Komuro A, Homma Y, Negoro T, Barber G, Horvath C. The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection. Biochem Biophys Res Commun. 2016;480:187-193 pubmed publisher
    ..The screening has identified the TAR-RNA binding protein (TRBP), which is known to be an essential factor for RNA interference (RNAi)...
  44. Park W, Rengaraj D, Kil D, Kim H, Lee H, Song K. RNA-seq analysis of the kidneys of broiler chickens fed diets containing different concentrations of calcium. Sci Rep. 2017;7:11740 pubmed publisher
    ..The National Research Council (NRC) recommended Ca intake for 21-day post-hatch broilers is about 1.0%...
  45. Surapureddi S, Yu S, Bu H, Hashimoto T, Yeldandi A, Kashireddy P, et al. Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. Proc Natl Acad Sci U S A. 2002;99:11836-41 pubmed
    ..PRIC complex includes known coactivators or coactivator-binding proteins (CBP, SRC-1, PBP, PRIP, PIMT, TRAP100, SUR-2, and PGC-1), other proteins that have not previously been described in association with ..
  46. Surendra A, Cuperlovic Culf M. Database of resistance related metabolites in Wheat Fusarium head blight Disease (MWFD). Database (Oxford). 2017;2017: pubmed publisher
  47. Kim J, Choi Y, Jin G, Kang H, Choi J, Jeon H, et al. Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study. Mol Carcinog. 2010;49:913-21 pubmed publisher
    ..24 SNPs in the 11 miRNA biosynthesis genes (DROSHA, DGCR8, RAN, XPO5, DICER, AGO1, AGO2, HIWI, GEMIN3, GEMIN4, and TRBP) were genotyped in 100 lung cancer patients and 100 healthy controls using a sequenome mass spectrometry-based ..
  48. Nakano K, Yamamoto T, Kishimoto T, Noji T, Tanaka K. Protein kinases Fpk1p and Fpk2p are novel regulators of phospholipid asymmetry. Mol Biol Cell. 2008;19:1783-97 pubmed publisher
    ..The kinase domain of Fpk1p exhibits high homology to plant phototropins and the fungus Neurospora crassa NRC-2, both of which have membrane-associated functions...
  49. Son Y, Park O, Kim G, Lee J, Lee Y. RXR heterodimerization allosterically activates LXR binding to the second NR box of activating signal co-integrator-2. Biochem J. 2008;410:319-30 pubmed
    ..These results indicate that RXR does not interact directly with NR box-1 of ASC-2, but functions as an allosteric activator of LXR binding to NR box-2 of ASC-2. ..
  50. Hong S, Lee M, Cheong J. Functional interaction of transcriptional coactivator ASC-2 and C/EBPalpha in granulocyte differentiation of HL-60 promyelocytic cell. Biochem Biophys Res Commun. 2001;282:1257-62 pubmed
  51. Zhang H, Sun L, Wang Z, Deng M, Nie H, Zhang G, et al. N-carbamylglutamate and L-arginine improved maternal and placental development in underfed ewes. Reproduction. 2016;151:623-35 pubmed publisher 35 to day 110 of gestation, 32 Hu ewes carrying twin fetuses were allocated randomly into four groups: 100% of NRC-recommended nutrient requirements, 50% of NRC recommendations, 50% of NRC recommendations supplemented with 20g/day ..
  52. Wang X, Vuković L, Koh H, Schulten K, Myong S. Dynamic profiling of double-stranded RNA binding proteins. Nucleic Acids Res. 2015;43:7566-76 pubmed publisher
    ..Here we examined four human dsRBPs, ADAD2, TRBP, Staufen 1 and ADAR1 on six dsRNA substrates that vary in length and secondary structure...
  53. Patel S, Kim D, Levitan I, Dressler G. The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Dev Cell. 2007;13:580-92 pubmed
    ..Embryonic lethal ptip-null mutants and conditional mutants both show reduced levels of methylated H3K4. Thus, PTIP bridges DNA-binding developmental regulators to histone methyltransferase-dependent epigenetic regulation. ..
  54. Dutta A, Khimji A, Sathe M, Kresge C, Parameswara V, Esser V, et al. Identification and functional characterization of the intermediate-conductance Ca(2+)-activated K(+) channel (IK-1) in biliary epithelium. Am J Physiol Gastrointest Liver Physiol. 2009;297:G1009-18 pubmed
    ..Expression of IK-1 mRNA was found in both human Mz-Cha-1 biliary cells and polarized normal rat cholangiocyte (NRC) monolayers, and immunostaining revealed membrane localization with a predominant basolateral signal...
  55. Ko L, Cardona G, Iwasaki T, Bramlett K, Burris T, Chin W. Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs. Mol Endocrinol. 2002;16:128-40 pubmed
    ..TR-binding protein (TRBP) interacts with nuclear receptors through a single LXXLL motif...
  56. Yang A, Xiao X, Liu Z, Wan Z, Wang Z. A multimodal MRI study of recovery of consciousness in severe traumatic brain injury: Preliminary results. J Neurotrauma. 2017;: pubmed publisher
    ..Total 33 patients gained recovery of consciousness (RC), and 25 did not (NRC). Comparing with RC, NRC had a significantly lower NAA/Cr of pons (1.43 ± 0.54 vs. 1.70 ± 0...
  57. Byun S, Kim J, Han D, Kwon M, Cho J, Ng H, et al. TRBP maintains mammalian embryonic neural stem cell properties by acting as a novel transcriptional coactivator of the Notch signaling pathway. Development. 2017;144:778-783 pubmed publisher
    Transactivation response element RNA-binding protein (TRBP; TARBP2) is known to play important roles in human immunodeficiency virus (HIV) replication and microRNA biogenesis...
  58. Mundt K, Gentry P, Dell L, Rodricks J, Boffetta P. Six years after the NRC review of EPA's Draft IRIS Toxicological Review of Formaldehyde: Regulatory implications of new science in evaluating formaldehyde leukemogenicity. Regul Toxicol Pharmacol. 2018;92:472-490 pubmed publisher
    ..of Science committee noted that "causal determinations are not supported by the narrative provided in the draft" (NRC 2011)...
  59. Antonson P, Jakobsson T, Almlöf T, Guldevall K, Steffensen K, Gustafsson J. RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3. J Biol Chem. 2008;283:8995-9001 pubmed publisher
    b>RAP250 is a coactivator for nuclear receptors as well as other transcription factors...
  60. Govindasamy V, George P, Aher L, Ramesh S, Thangasamy A, Anandan S, et al. Comparative conventional and phenomics approaches to assess symbiotic effectiveness of Bradyrhizobia strains in soybean (Glycine max L. Merrill) to drought. Sci Rep. 2017;7:6958 pubmed publisher
    Symbiotic effectiveness of rhizobitoxine (Rtx)-producing strains of Bradyrhizobium spp. in soybean (cultivar NRC-37/Ahilya-4) under limited soil moisture conditions was evaluated using phenomics tools such as infrared(IR) thermal and ..
  61. Lee M, Villa R, Trojer P, Norman J, Yan K, Reinberg D, et al. Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science. 2007;318:447-50 pubmed
    ..Our results suggest a concerted mechanism for transcriptional activation in which cycles of H3K4 methylation by MLL2/3 are linked with the demethylation of H3K27 through UTX. ..
  62. Bauer J, Scheibel T. Conformational Stability and Interplay of Helical N- and C-Terminal Domains with Implications on Major Ampullate Spidroin Assembly. Biomacromolecules. 2017;18:835-845 pubmed publisher
    ..hydrophobic stretches being hidden from the solvent and the hydrophilic nonrepetitive amino (NRN) and carboxy (NRC) terminal domains being exposed on the micelle surface...
  63. Hong S, Choi H, Park M, Kim Y, Choi Y, Kim H, et al. Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid. J Biol Chem. 2004;279:16996-7003 pubmed
  64. Na S, Choi J, Kim H, Jhun B, Lee Y, Lee J. Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation. J Biol Chem. 1999;274:28491-6 pubmed
    ..These results suggest that Bcl3 may directly participate in the tumorigenesis processes as a novel transcription coactivator of the mitogenic transcription factor AP-1 in vivo. ..
  65. Estey A, Kemp M, Allison S, Lamb C. Evaluation of a patient information booklet. J Nurs Staff Dev. 1993;9:278-82 pubmed
  66. Lee S, Lee D, Dou Y, Lee J, Lee B, Kwak E, et al. Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc Natl Acad Sci U S A. 2006;103:15392-7 pubmed
    ..Here, we show that mice expressing a SET domain mutant of MLL3 share phenotypes with isogenic ASC2+/- mice and that expression and H3-K4 trimethylation of RAR target gene RAR-beta2 are impaired in ASC-2-null mouse ..
  67. Carney J, McKnight C, VanEpps S, Kelley M. Random rapid amplification of cDNA ends (RRACE) allows for cloning of multiple novel human cDNA fragments containing (CAG)n repeats. Gene. 1995;155:289-92 pubmed
    ..If only a partial sequence of a gene is known, our system, described here, provides a rapid and efficient method for isolating a fragment of the gene of interest. ..
  68. Acetoze G, Champagne J, Ramsey J, Rossow H. Liver mitochondrial oxygen consumption and efficiency of milk production in lactating Holstein cows supplemented with copper, manganese and zinc. J Anim Physiol Anim Nutr (Berl). 2017;: pubmed publisher
    ..of different levels of Cu, Mn and Zn (Bioplex, Alltech) at levels above Nutrient Requirements of Dairy Cattle (NRC, 2001)...
  69. Gionbelli T, Veloso C, Rotta P, Valadares Filho S, C Carvalho B, Marcondes M, et al. Foetal development of skeletal muscle in bovines as a function of maternal nutrition, foetal sex and gestational age. J Anim Physiol Anim Nutr (Berl). 2017;: pubmed publisher
    ..and possible increase in the potential of skeletal muscle growth in cattle, gestating cows were either fed 190% NRC recommendations (overnourished; ON) or 100% NRC recommendation (control; CO)...
  70. Espejo F, Green M, Preece N, Assa Munt N. NMR assignment of human ASC2, a self contained protein interaction domain involved in apoptosis and inflammation. J Biomol NMR. 2002;23:151-2 pubmed
  71. Zhu Y, Qi C, Cao W, Yeldandi A, Rao M, Reddy J. Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function. Proc Natl Acad Sci U S A. 2001;98:10380-5 pubmed
    ..library by using the coactivator peroxisome proliferator-activated receptor-interacting protein (PRIP) (ASC2/AIB3/RAP250/NRC/TRBP) as bait in a yeast two-hybrid screen...
  72. Laye V, Dassarma S. An Antarctic Extreme Halophile and Its Polyextremophilic Enzyme: Effects of Perchlorate Salts. Astrobiology. 2017;: pubmed publisher
    ..For a purified halophilic ?-galactosidase enzyme of H. lacusprofundi expressed in Halobacterium sp. NRC-1, 50% inhibition of catalytic activity was observed at 0.88?M NaClO4 and 0...
  73. Surapureddi S, Rana R, Reddy J, Goldstein J. Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha. Mol Pharmacol. 2008;74:913-23 pubmed publisher
    b>Nuclear receptor coactivator 6 (NCOA6) also known as PRIP/RAP250/ASC-2 anchors a steady-state complex of cofactors and function as a transcriptional coactivator for certain nuclear receptors...
  74. Lee G, Elwood F, McNally J, Weiszmann J, Lindstrom M, Amaral K, et al. T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. J Biol Chem. 2002;277:19649-57 pubmed
    ..These results suggest that the activity of PPARgamma antagonists can be modulated by the availability and concentration of RXR agonists. T0070907 is a novel tool for the study of PPARgamma/RXRalpha heterodimer function. ..
  75. Scoville D, Cyphert H, Liao L, Xu J, Reynolds A, Guo S, et al. MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function. Diabetes. 2015;64:3772-83 pubmed publisher
    ..Knockdown of NCOA6, a core subunit of these methyltransferases, reduced expression of a subset of MAFA and MAFB target genes in mouse ..
  76. Zhang F, Zheng W, Guo R, Yao W. Effect of dietary copper level on the gut microbiota and its correlation with serum inflammatory cytokines in Sprague-Dawley rats. J Microbiol. 2017;55:694-702 pubmed publisher
    In China's swine industry, copper is generally supplemented above the National Research Council (NRC) requirement (2012) because of its antimicrobial properties and the potential for growth promotion...
  77. Yoon J, Lee K, Oh G, Kim G, Kim S. Regulation of Nampt expression by transcriptional coactivator NCOA6 in pancreatic ?-cells. Biochem Biophys Res Commun. 2017;487:600-606 pubmed publisher
    b>Nuclear receptor coactivator 6 (NCOA6) is a transcriptional coactivator and crucial for insulin secretion and glucose metabolism in pancreatic ?-cells. However, the regulatory mechanism of ?-cell function by NCOA6 is largely unknown...
  78. Choi E, Lee S, Yeom S, Kim G, Lee J, Kim S. Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor. Mol Endocrinol. 2005;19:1711-9 pubmed
    ..Taken together, these results strongly suggest that ASC-2 is a bona fide coactivator of the xenobiotic nuclear receptor CAR and mediate the specific xenobiotic response by CAR in vivo. ..
  79. Jonkers W, Fischer M, Do H, Starr T, Glass N. Chemotropism and Cell Fusion in Neurospora crassa Relies on the Formation of Distinct Protein Complexes by HAM-5 and a Novel Protein HAM-14. Genetics. 2016;203:319-34 pubmed publisher
    ..The kinase pathway components (NRC-1, MEK-2 and MAK-2) and the scaffold protein HAM-5 are recruited to hyphae and germling tips undergoing chemotropic ..