Gene Symbol: NCOA2
Description: nuclear receptor coactivator 2
Alias: GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75, nuclear receptor coactivator 2, class E basic helix-loop-helix protein 75, glucocorticoid receptor-interacting protein-1, p160 steroid receptor coactivator 2, transcriptional intermediary factor 2
Species: human
Products:     NCOA2

Top Publications

  1. Beischlag T, Wang S, Rose D, Torchia J, Reisz Porszasz S, Muhammad K, et al. Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex. Mol Cell Biol. 2002;22:4319-33 pubmed
    ..Taken together, these data support a role for the SRC family of transcriptional coactivators in TCDD-dependent gene regulation. ..
  2. Chopra A, Kommagani R, Saha P, Louet J, Salazar C, Song J, et al. Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption. Cell Metab. 2011;13:35-43 pubmed publisher
    ..Our results position the hepatic AMPK-SRC-2 axis as an energy rheostat, which upon cellular energy depletion resets whole-body energy by promoting absorption of dietary fuel...
  3. Lee Y, Coonrod S, Kraus W, Jelinek M, Stallcup M. Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination. Proc Natl Acad Sci U S A. 2005;102:3611-6 pubmed
    ..synergy of the p160 coactivators [steroid receptor coactivator-1, glucocorticoid receptor interacting protein (GRIP1), or the activator for thyroid hormone and retinoid receptors], the histone acetyltransferases cAMP response ..
  4. Kommagani R, Szwarc M, Kovanci E, Gibbons W, Putluri N, Maity S, et al. Acceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization. PLoS Genet. 2013;9:e1003900 pubmed publisher
  5. Nakayama R, Miura Y, Ogino J, Susa M, Watanabe I, Horiuchi K, et al. Detection of HEY1-NCOA2 fusion by fluorescence in-situ hybridization in formalin-fixed paraffin-embedded tissues as a possible diagnostic tool for mesenchymal chondrosarcoma. Pathol Int. 2012;62:823-6 pubmed publisher
    Mesenchymal chondrosarcoma (MC) is an extremely rare subtype of chondrosarcoma. A tumor specific fusion gene, HEY1-NCOA2 fusion, was recently identified in this tumor...
  6. Chen Y, Kim J, Stallcup M. GAC63, a GRIP1-dependent nuclear receptor coactivator. Mol Cell Biol. 2005;25:5965-72 pubmed
    ..One important coactivator complex includes a p160 coactivator (GRIP1, SRC-1, or ACTR) and its downstream coactivators (e.g...
  7. Voegel J, Heine M, Tini M, Vivat V, Chambon P, Gronemeyer H. The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J. 1998;17:507-19 pubmed
    The nuclear receptor (NR) coactivator TIF2 possesses a single NR interaction domain (NID) and two autonomous activation domains, AD1 and AD2. The TIF2 NID is composed of three NR-interacting modules each containing the NR box motif LxxLL...
  8. Kindle K, Troke P, Collins H, Matsuda S, Bossi D, Bellodi C, et al. MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function. Mol Cell Biol. 2005;25:988-1002 pubmed
    ..of the genes encoding the acetyltransferase MOZ or MORF with genes encoding the nuclear receptor coactivator TIF2, p300, or CBP...
  9. Razeto A, Ramakrishnan V, Litterst C, Giller K, Griesinger C, Carlomagno T, et al. Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain. J Mol Biol. 2004;336:319-29 pubmed
    ..Therefore surface complementarity between the hydrophobic faces of the STAT6 fragment and of the NCoA-1 PAS-B domain almost exclusively defines the binding specificity between the two proteins. ..

More Information


  1. Fenne I, Hoang T, Hauglid M, Sagen J, Lien E, Mellgren G. Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase. Endocrinology. 2008;149:4336-45 pubmed publisher
    Steroid receptor coactivators (SRCs), such as glucocorticoid receptor interacting protein 1 (GRIP1) are recruited to the DNA-bound nuclear receptors (NRs) and are also shown to enhance the gene transactivation by other transcription ..
  2. Lodrini M, Münz T, Coudevylle N, Griesinger C, Becker S, Pfitzner E. P160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain. Nucleic Acids Res. 2008;36:1847-60 pubmed publisher
    ..Our study discloses a new, complementary mechanism for the current model of coactivator recruitment to target gene promoters. ..
  3. Hoang T, Fenne I, Madsen A, Bozickovic O, Johannessen M, Bergsvåg M, et al. cAMP response element-binding protein interacts with and stimulates the proteasomal degradation of the nuclear receptor coactivator GRIP1. Endocrinology. 2013;154:1513-27 pubmed publisher
    The glucocorticoid receptor interacting protein (GRIP1) belongs to the p160 steroid receptor coactivator family that plays essential roles in nuclear receptor-dependent transcriptional regulation...
  4. Carrero P, Okamoto K, Coumailleau P, O BRIEN S, Tanaka H, Poellinger L. Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha. Mol Cell Biol. 2000;20:402-15 pubmed
    ..coactivators harboring histone acetyltransferase activity, SRC-1 and transcription intermediary factor 2 (TIF2), are able to interact with HIF-1alpha and enhance its transactivation potential in a hypoxia-dependent manner...
  5. Sugiyama T, Wang J, Scott D, Granner D. Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene. J Biol Chem. 2000;275:3446-54 pubmed
    ..Furthermore, we show that GRIP1 and SRC-1 potentiate the activity of COUP-TFI and that COUP-TFI associates with these coactivators in vivo using ..
  6. Carapeti M, Aguiar R, Goldman J, Cross N. A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia. Blood. 1998;91:3127-33 pubmed
    ..same leukemia phenotype, and found a novel fusion between MOZ and the nuclear receptor transcriptional coactivator TIF2/GRIP-1/NCoA-2. This gene has not previously been implicated in the pathogenesis of leukemia or other malignancies...
  7. Jin Y, Möller E, Nord K, Mandahl N, Von Steyern F, Domanski H, et al. Fusion of the AHRR and NCOA2 genes through a recurrent translocation t(5;8)(p15;q13) in soft tissue angiofibroma results in upregulation of aryl hydrocarbon receptor target genes. Genes Chromosomes Cancer. 2012;51:510-20 pubmed publisher
    ..FISH mapping suggested the involvement of the aryl hydrocarbon receptor repressor (AHRR) and nuclear receptor coactivator 2 (NCOA2) genes in 5p15 and 8q13, respectively...
  8. Collins H, Kindle K, Matsuda S, Ryan C, Troke P, Kalkhoven E, et al. MOZ-TIF2 alters cofactor recruitment and histone modification at the RARbeta2 promoter: differential effects of MOZ fusion proteins on CBP- and MOZ-dependent activators. J Biol Chem. 2006;281:17124-33 pubmed
    MOZ-TIF2 and MOZ-CBP are leukemogenic fusion proteins associated with therapy-induced acute myeloid leukemia. These proteins are thought to subvert normal gene expression in differentiating hematopoietic progenitor cells...
  9. Karmakar S, Foster E, Smith C. Unique roles of p160 coactivators for regulation of breast cancer cell proliferation and estrogen receptor-alpha transcriptional activity. Endocrinology. 2009;150:1588-96 pubmed publisher
  10. Torchia J, Rose D, Inostroza J, Kamei Y, Westin S, Glass C, et al. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature. 1997;387:677-84 pubmed
  11. Deguchi K, Ayton P, Carapeti M, Kutok J, Snyder C, Williams I, et al. MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP. Cancer Cell. 2003;3:259-71 pubmed
    The MOZ-TIF2 fusion is associated with acute myeloid leukemia (AML) with inv(8)(p11q13). MOZ is a MYST family histone acetyltransferase (HAT), whereas TIF2 is a nuclear receptor coactivator that associates with CREB binding protein (CBP)...
  12. Strehl S, Nebral K, König M, Harbott J, Strobl H, Ratei R, et al. ETV6-NCOA2: a novel fusion gene in acute leukemia associated with coexpression of T-lymphoid and myeloid markers and frequent NOTCH1 mutations. Clin Cancer Res. 2008;14:977-83 pubmed publisher
    ..which results in a fusion between the transcriptional repressor ETV6 (TEL) and the transcriptional coactivator NCOA2 (TIF2) in six cases of childhood leukemia expressing both T-lymphoid and myeloid antigens...
  13. Voegel J, Heine M, Zechel C, Chambon P, Gronemeyer H. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J. 1996;15:3667-75 pubmed
    ..We report here the cloning of the 160 kDa human nuclear protein TIF2, which exhibits all properties expected for a mediator of AF-2: (i) it interacts in vivo with NRs in an agonist-..
  14. Bledsoe R, Montana V, Stanley T, Delves C, Apolito C, McKee D, et al. Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. Cell. 2002;110:93-105 pubmed
    ..GR ligand binding domain (LBD) bound to dexamethasone and a coactivator motif derived from the transcriptional intermediary factor 2. Despite structural similarity to other steroid receptors, the GR LBD adopts a surprising dimer ..
  15. Chen D, Ma H, Hong H, Koh S, Huang S, Schurter B, et al. Regulation of transcription by a protein methyltransferase. Science. 1999;284:2174-7 pubmed
    The p160 family of coactivators, SRC-1, GRIP1/TIF2, and p/CIP, mediate transcriptional activation by nuclear hormone receptors...
  16. Gregory C, Wilson E, Apparao K, Lininger R, Meyer W, Kowalik A, et al. Steroid receptor coactivator expression throughout the menstrual cycle in normal and abnormal endometrium. J Clin Endocrinol Metab. 2002;87:2960-6 pubmed
    ..Based on these findings, we suggest a possible mechanism to explain the poor reproductive performance observed in PCOS and the increased incidence of endometrial hyperplasia and cancer noted in this group of women. ..
  17. Båvner A, Johansson L, Toresson G, Gustafsson J, Treuter E. A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP. EMBO Rep. 2002;3:478-84 pubmed
    ..We suggest histone acetyltransferases and histones as targets for EID1 action and propose that SHP inhibition of transcription involves EID1 antagonism of CBP/p300-dependent coactivator functions. ..
  18. McKenna N, Nawaz Z, Tsai S, Tsai M, O Malley B. Distinct steady-state nuclear receptor coregulator complexes exist in vivo. Proc Natl Acad Sci U S A. 1998;95:11697-702 pubmed
    ..that liganded PR is present in stable complexes containing SRC-1 and transcription intermediary factor 2 (TIF2) in vivo...
  19. Molnár F, Matilainen M, Carlberg C. Structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators. J Biol Chem. 2005;280:26543-56 pubmed
    ..This leads to high basal activity of PPARs and provides an additional view on PPAR signaling. ..
  20. Rogatsky I, Luecke H, Leitman D, Yamamoto K. Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts. Proc Natl Acad Sci U S A. 2002;99:16701-6 pubmed
    Members of the mammalian p160 family, such as GRIP1, are known as glucocorticoid receptor (GR) coactivators; at certain glucocorticoid response elements (GREs), however, GRIP1 acts as a GR corepressor...
  21. Lin C, Hare B, Wagner G, Harrison S, Maniatis T, Fraenkel E. A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies. Mol Cell. 2001;8:581-90 pubmed
    ..We demonstrate the significance both in vitro and in vivo of interactions between IBiD and a number of diverse partners. Thus, IBiD is an important contributor to signal integration by CBP and p300. ..
  22. Koh S, Chen D, Lee Y, Stallcup M. Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities. J Biol Chem. 2001;276:1089-98 pubmed
    ..e. GRIP1, CARM1, and PRMT1...
  23. Ma H, Hong H, Huang S, Irvine R, Webb P, Kushner P, et al. Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins. Mol Cell Biol. 1999;19:6164-73 pubmed
    ..Here we report that the C-terminal region of p160 coactivators glucocorticoid receptor interacting protein 1 (GRIP1), steroid receptor coactivator 1 (SRC-1a), and SRC-1e binds the N-terminal AF-1 ..
  24. Mukherjee A, Amato P, Allred D, DeMayo F, Lydon J. Steroid receptor coactivator 2 is required for female fertility and mammary morphogenesis: insights from the mouse, relevance to the human. Nucl Recept Signal. 2007;5:e011 pubmed publisher
    ..Finally, the recent detection of SRC-2 in the human endometrium and breast suggests that this coregulator may represent a new clinical target for the future management of female reproductive health and/or breast cancer. ..
  25. Berrevoets C, Doesburg P, Steketee K, Trapman J, Brinkmann A. Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor2). Mol Endocrinol. 1998;12:1172-83 pubmed
    ..The AF-2 AD core region was also involved in the interaction with the coactivator TIF2 (transcriptional intermediary factor 2), as the E888Q mutation decreased the stimulatory effect of TIF2 on AR AF-2 activity...
  26. Wang L, Motoi T, Khanin R, Olshen A, Mertens F, Bridge J, et al. Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data. Genes Chromosomes Cancer. 2012;51:127-39 pubmed publisher
    ..The transcription factor gene NCOA2 was one of the candidates identified in a mesenchymal chondrosarcoma...
  27. Mosquera J, Sboner A, Zhang L, Kitabayashi N, Chen C, Sung Y, et al. Recurrent NCOA2 gene rearrangements in congenital/infantile spindle cell rhabdomyosarcoma. Genes Chromosomes Cancer. 2013;52:538-50 pubmed publisher
    ..An SRF-NCOA2 fusion was detected in a spindle cell RMS from the posterior neck in a 7-month-old child...
  28. Frigo D, Basu A, Nierth Simpson E, Weldon C, Dugan C, Elliott S, et al. p38 mitogen-activated protein kinase stimulates estrogen-mediated transcription and proliferation through the phosphorylation and potentiation of the p160 coactivator glucocorticoid receptor-interacting protein 1. Mol Endocrinol. 2006;20:971-83 pubmed
    ..pharmacological and molecular techniques that the p160 coactivator glucocorticoid receptor-interacting protein 1 (GRIP1) is phosphorylated and potentiated by the p38 MAPK signaling cascade in vitro and in vivo...
  29. Hong H, Kohli K, Garabedian M, Stallcup M. GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. Mol Cell Biol. 1997;17:2735-44 pubmed
    ..A search for possible coactivators for steroid hormone receptors resulted in identification of glucocorticoid receptor interacting protein 1 (GRIP1)...
  30. Benecke A, Chambon P, Gronemeyer H. Synergy between estrogen receptor alpha activation functions AF1 and AF2 mediated by transcription intermediary factor TIF2. EMBO Rep. 2000;1:151-7 pubmed
    ..Recent evidence indicates that coactivators, such as the transcription intermediary factor TIF2, also bind to and transactivate the N-terminal AF1 function of the two ERs...
  31. Kefalopoulou Z, Tzelepi V, Zolota V, Grivas P, Christopoulos C, Kalofonos H, et al. Prognostic value of novel biomarkers in astrocytic brain tumors: nuclear receptor co-regulators AIB1, TIF2, and PELP1 are associated with high tumor grade and worse patient prognosis. J Neurooncol. 2012;106:23-31 pubmed publisher
    ..of the present study is to evaluate the differential protein expression of ?R?, ER?, and their co-activators, AIB1, TIF2, and PELP1 in astrocytic tumors of World Health Organization (WHO) grade II-IV, using immunohistochemistry...
  32. Nicolaides N, Skyrla E, Vlachakis D, Psarra A, Moutsatsou P, Sertedaki A, et al. Functional characterization of the hGRαT556I causing Chrousos syndrome. Eur J Clin Invest. 2016;46:42-9 pubmed publisher
    ..The hGRαT556I causes Chrousos syndrome by impairing multiple steps of the glucocorticoid signal transduction pathway. ..
  33. Lee Y, Yoon K, Joo J, Lee D, Bae K, Han J, et al. Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. Carcinogenesis. 2013;34:307-13 pubmed publisher
    ..These SNPs were located in the genomic regions of the FAM154A, ANKS1A, DLST, THSD7B, NCOA2, CDH8, SLC35D2, NALCN and EGF genes. The most significant SNP, rs1571228 (9p22...
  34. Schmelzer C, Kohl C, Rimbach G, Döring F. The reduced form of coenzyme Q10 decreases the expression of lipopolysaccharide-sensitive genes in human THP-1 cells. J Med Food. 2011;14:391-7 pubmed publisher
    ..32 and 1.65. The strongest effect of Q(10)H(2) incubation was found for the nuclear receptor coactivator 2 gene (NCOA2). Gene ontology terms revealed for the Q(10)H(2)-sensitive genes an involvement in, e.g...
  35. Ellison T, Dowd D, MacDonald P. Calmodulin-dependent kinase IV stimulates vitamin D receptor-mediated transcription. Mol Endocrinol. 2005;19:2309-19 pubmed
  36. Stashi E, Lanz R, Mao J, Michailidis G, Zhu B, Kettner N, et al. SRC-2 is an essential coactivator for orchestrating metabolism and circadian rhythm. Cell Rep. 2014;6:633-45 pubmed publisher
    ..Collectively, our data suggest that SRC-2 is a transcriptional coactivator of the BMAL1:CLOCK oscillators and establish SRC-2 as a critical positive regulator of the mammalian circadian clock. ..
  37. Rochel N, Ciesielski F, Godet J, Moman E, Roessle M, Peluso Iltis C, et al. Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings. Nat Struct Mol Biol. 2011;18:564-70 pubmed publisher
    ..The results reveal two additional features: the conserved position of the ligand-binding domains at the 5' ends of the target DNAs and the binding of only one coactivator molecule per heterodimer, to RXR's partner. ..
  38. Båvner A, Matthews J, Sanyal S, Gustafsson J, Treuter E. EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation. Nucleic Acids Res. 2005;33:3561-9 pubmed
    ..Our study suggests that EID-family members EID3 and EID1 act as inhibitors of CBP/p300-dependent transcription in a tissue-specific manner. ..
  39. Liu H, Ma Z, Zhang T, Yu N, Su G, Giesy J, et al. Pharmacokinetics and effects of tetrabromobisphenol a (TBBPA) to early life stages of zebrafish (Danio rerio). Chemosphere. 2018;190:243-252 pubmed publisher
    ..5 × 102 μg TBBPA/L significantly down-regulated expression of ThRα and associated genes, ncor, c1d, ncoa2, ncoa3, and ncoa4, in the AR pathway and of er2a and er2b genes in the ER pathway.
  40. Bozickovic O, Hoang T, Fenne I, Helland T, Skartveit L, Ouchida M, et al. Cyclin C interacts with steroid receptor coactivator 2 and upregulates cell cycle genes in MCF-7 cells. Biochim Biophys Acta. 2015;1853:2383-91 pubmed publisher
    ..In conclusion, our results suggest that CCNC temporarily protects SRC-2 against degradation and this event is involved in the transcriptional regulation of SRC-2 cell cycle target genes. ..
  41. Lou X, Toresson G, Benod C, Suh J, Philips K, Webb P, et al. Structure of the retinoid X receptor ?-liver X receptor ? (RXR?-LXR?) heterodimer on DNA. Nat Struct Mol Biol. 2014;21:277-81 pubmed publisher
    ..Comparisons of RXR?-LXR?s in the crystal asymmetric unit and with previous NR structures reveal flexibility in NR organization and suggest a role for RXR? in adaptation of heterodimeric complexes to DNA. ..
  42. Liu P, Hsieh T, Chou W, Huang S. Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domains. FEBS J. 2006;273:2172-83 pubmed
    Glucocorticoid receptor-interacting protein 1 (GRIP1), a p160 family nuclear receptor co-activator, possesses at least two autonomous activation domains (AD1 and AD2) in the C-terminal region...
  43. Zechel C. Synthetic retinoids dissociate coactivator binding from corepressor release. J Recept Signal Transduct Res. 2002;22:31-61 pubmed
    ..Moreover, this retinoid discriminates between the nuclear corepressors SMRT and NCoR, since it efficiently dissociates SMRT but not NCoR from the RARalpha LBD. ..
  44. Jaber B, Mukopadhyay R, Smith C. Estrogen receptor-alpha interaction with the CREB binding protein coactivator is regulated by the cellular environment. J Mol Endocrinol. 2004;32:307-23 pubmed
    The p160 coactivators, steroid receptor coactivator-1 (SRC-1), transcriptional intermediary factor-2 (TIF2) and receptor-associated coactivator-3 (RAC3), as well as the coactivator/integrator CBP, mediate estrogen receptor-alpha (ERalpha)-..
  45. Lee W, Noy N. Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain. Biochemistry. 2002;41:2500-8 pubmed
    ..mutation of the H11 phenylalanine residues diminishes the ability of RXR to associate with the p160 coactivators TIF2 and p/CIP, but has little effect on ligand-dependent interactions of the receptor with the unrelated coactivator ..
  46. Itoh Y, Fuchino H, Sanosaka M, Kako K, Hada K, Fukamizu A, et al. Pterosin B has multiple targets in gluconeogenic programs, including coenzyme Q in RORα-SRC2 signaling. Biochem Biophys Res Commun. 2016;473:415-20 pubmed publisher
    ..actions revealed that retinoic acid receptor-related orphan receptor alpha-steroid receptor coactivator 2 (RORα-SRC2) complex on the G6pc promoter was the target...
  47. Shima H, Yamagata K, Aikawa Y, Shino M, Koseki H, Shimada H, et al. Bromodomain-PHD finger protein 1 is critical for leukemogenesis associated with MOZ-TIF2 fusion. Int J Hematol. 2014;99:21-31 pubmed publisher
    ..To assess the functional role of HOX upregulation in leukemogenesis by MOZ-TIF2, we focused on bromodomain-PHD finger protein 1 (BRPF1), a component of the MOZ complex that carries out histone ..
  48. Boerma L, Xia G, Qui C, Cox B, Chalmers M, Smith C, et al. Defining the communication between agonist and coactivator binding in the retinoid X receptor α ligand binding domain. J Biol Chem. 2014;289:814-26 pubmed publisher
    ..They serve as hallmarks for how RXR changes conformation and dynamics in the presence of agonist and coactivator to initiate signaling. ..
  49. Lin D, Fang H, Ma A, Huang Y, Pu Y, Jenster G, et al. Negative modulation of androgen receptor transcriptional activity by Daxx. Mol Cell Biol. 2004;24:10529-41 pubmed
    ..Together, these findings not only provide a novel role of Daxx in controlling AR transactivation activity but also uncover the mechanism underlying sumoylation-dependent transcriptional repression of the AR. ..
  50. Cui Y, Niu A, Pestell R, Kumar R, Curran E, Liu Y, et al. Metastasis-associated protein 2 is a repressor of estrogen receptor alpha whose overexpression leads to estrogen-independent growth of human breast cancer cells. Mol Endocrinol. 2006;20:2020-35 pubmed
    ..We hypothesize that MTA2 is a repressor of ERalpha activity and that it could represent a new therapeutic target of ERalpha action in human breast tumors. ..
  51. Feng S, Tang Q, Sun M, Chun J, Evans C, Gao A. Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2. Mol Cancer Ther. 2009;8:665-71 pubmed publisher
    ..The levels of transcriptional intermediary factor 2 (TIF2) in IL-6-treated LNCaP cells were found to be significantly higher than parental LNCaP cells...
  52. de Vera I, Zheng J, Novick S, Shang J, Hughes T, Brust R, et al. Synergistic Regulation of Coregulator/Nuclear Receptor Interaction by Ligand and DNA. Structure. 2017;25:1506-1518.e4 pubmed publisher
    ..that ligand and DNA cooperatively recruit the intrinsically disordered steroid receptor coactivator-2 (SRC-2/TIF2/GRIP1/NCoA-2) receptor interaction domain to peroxisome proliferator-activated receptor gamma-retinoid X receptor alpha (..
  53. Wu R, Qin J, Hashimoto Y, Wong J, Xu J, Tsai S, et al. Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase. Mol Cell Biol. 2002;22:3549-61 pubmed
    ..frequently studied of these coactivators are members of the steroid receptor coactivator (SRC) family, SRC-1, TIF2/GRIP1/SRC-2, and pCIP/ACTR/AIB-1/RAC-3/TRAM-1/SRC-3...
  54. Eng F, Barsalou A, Akutsu N, Mercier I, Zechel C, Mader S, et al. Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain. J Biol Chem. 1998;273:28371-7 pubmed
  55. Yang C, Kim J, Li H, Stallcup M. Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1. J Biol Chem. 2006;281:3389-97 pubmed
    ..Three components of the p160 nuclear receptor coactivator complex, including CARM1, p300/CBP, and GRIP1 (one of the p160 coactivators), bind to and cooperate with beta-catenin to enhance transcriptional activation by ..
  56. Wang J, STAFFORD J, Granner D. SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4. J Biol Chem. 1998;273:30847-30850 pubmed
    ..In this study, we show that SRC-1 and GRIP1, which act as coactivators for various nuclear receptors, associate with HNF4 in vivo and enhance its ..
  57. Reinl E, England S. Fetal-to-maternal signaling to initiate parturition. J Clin Invest. 2015;125:2569-71 pubmed publisher
    ..This work underscores the importance of the fetus as a contributor to the onset of murine, and potentially human, parturition. ..
  58. Eedunuri V, Rajapakshe K, Fiskus W, Geng C, Chew S, Foley C, et al. miR-137 Targets p160 Steroid Receptor Coactivators SRC1, SRC2, and SRC3 and Inhibits Cell Proliferation. Mol Endocrinol. 2015;29:1170-83 pubmed publisher
    ..p160 SRCs by microRNAs, we used and combined 4 prediction algorithms to identify microRNAs that could target SRC1, SRC2, and SRC3 expression...
  59. Avenant C, Kotitschke A, Hapgood J. Glucocorticoid receptor phosphorylation modulates transcription efficacy through GRIP-1 recruitment. Biochemistry. 2010;49:972-85 pubmed publisher
  60. Cohen J, Solomon D, Horvai A, Kakar S. Pancreatic involvement by mesenchymal chondrosarcoma harboring the HEY1-NCOA2 gene fusion. Hum Pathol. 2016;58:35-40 pubmed publisher
    ..Molecular testing demonstrated that both tumors harbored the recently described HEY1-NCOA2 gene fusion...
  61. Quint K, Cleven A, Vermeer M. Special variant of histiocytosis. BMJ Case Rep. 2017;2017: pubmed publisher
    ..The diagnosis is currently based on presence and absence of immunohistochemical markers. The current case described an indeterminate cell histiocytosis with ETV3-NCOA2 translocation.
  62. Shi X, Xu W, Dai H, Sun Y, Wang X. The role of SRC1 and SRC2 in steroid-induced SDF1 expression in normal and ectopic endometrium. Reproduction. 2014;147:847-53 pubmed publisher
    ..factor 1 (CXCL12 (SDF1)) in normal and ectopic endometrium and to explore the roles of NCOA1 (SRC1) and NCOA2 (SRC2) in the steroid-induced CXCL12 expression in normal and ectopic endometrial stromal cells (ESCs)...
  63. Cho M, Yoon H, Kang J, Park S, Yang Y, Hong J, et al. A simple method to screen ligands of peroxisome proliferator-activated receptor delta. Eur J Pharm Sci. 2006;29:355-60 pubmed
    ..We optimized and developed a novel and useful ELISA system for the mass screening of PPARdelta ligands. This screening system may be useful in the development of drugs for metabolic disorders and skin disorders. ..
  64. Yin H, Glass J, Blanchard K. MOZ-TIF2 repression of nuclear receptor-mediated transcription requires multiple domains in MOZ and in the CID domain of TIF2. Mol Cancer. 2007;6:51 pubmed
    Fusion of the MOZ and TIF2 genes by an inv (8) (p11q13) translocation has been identified in patients with acute mixed-lineage leukemia...
  65. Karmakar S, Foster E, Blackmore J, Smith C. Distinctive functions of p160 steroid receptor coactivators in proliferation of an estrogen-independent, tamoxifen-resistant breast cancer cell line. Endocr Relat Cancer. 2011;18:113-27 pubmed publisher
  66. Yu J, Wu W, Liang Q, Zhang N, He J, Li X, et al. Disruption of NCOA2 by recurrent fusion with LACTB2 in colorectal cancer. Oncogene. 2016;35:187-95 pubmed publisher
    ..A tumor-specific LACTB2-NCOA2 fusion originating from intra-chromosomal rearrangement of chromosome 8 was identified at both DNA and RNA levels...
  67. Silva M, Barros Silva J, Vieira J, Lisboa S, Torres L, Correia C, et al. NCOA2 is a candidate target gene of 8q gain associated with clinically aggressive prostate cancer. Genes Chromosomes Cancer. 2016;55:365-74 pubmed publisher
    ..false discovery rate [FDR], ≤ 5%) in tumors with relative 8q24 gain, namely VN1R1, ZNF417, CDON, IKZF2, and NCOA2. Of these, only NCOA2 is located in 8q (8q13...
  68. Cavarretta I, Mukopadhyay R, Lonard D, Cowsert L, Bennett C, O Malley B, et al. Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation. Mol Endocrinol. 2002;16:253-70 pubmed
    ..receptor coactivator (SRC) family members, such as steroid receptor coactivator-1 (SRC-1) and transcriptional intermediary factor 2 (TIF2) exert their biological effects as proteins...
  69. Wärnmark A, Treuter E, Gustafsson J, Hubbard R, Brzozowski A, Pike A. Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha. J Biol Chem. 2002;277:21862-8 pubmed
    ..we characterized the interaction between estrogen receptor alpha and the NR box regions of the p160 coactivator TIF2. We have determined the crystal structures of complexes between the ligand-binding domain of estrogen receptor ..
  70. Monroe D, Johnsen S, Subramaniam M, Getz B, Khosla S, Riggs B, et al. Mutual antagonism of estrogen receptors alpha and beta and their preferred interactions with steroid receptor coactivators in human osteoblastic cell lines. J Endocrinol. 2003;176:349-57 pubmed
    ..resulted in preferential transcriptional enhancement by ERbeta as well as coexpressed ERalpha and ERbeta, whereas SRC2 overexpression appeared to preferentially enhance ERalpha transactivation...
  71. Yoshida H, Miyachi M, Sakamoto K, Ouchi K, Yagyu S, Kikuchi K, et al. PAX3-NCOA2 fusion gene has a dual role in promoting the proliferation and inhibiting the myogenic differentiation of rhabdomyosarcoma cells. Oncogene. 2014;33:5601-8 pubmed publisher
    ..rhabdomyosarcoma (RMS) and showed that it generates the fusion gene PAX3 (paired box 3)-NCOA2 (nuclear receptor coactivator 2)...
  72. Jimenez Lara A, Heine M, Gronemeyer H. PIAS3 (protein inhibitor of activated STAT-3) modulates the transcriptional activation mediated by the nuclear receptor coactivator TIF2. FEBS Lett. 2002;526:142-6 pubmed
    PIAS3, a member of the protein inhibitor of activated STAT family, was found to interact in vivo and in vitro with TIF2, a previously described coactivator for nuclear receptors...