NCBP1

Summary

Gene Symbol: NCBP1
Description: nuclear cap binding protein subunit 1
Alias: CBP80, NCBP, Sto1, nuclear cap-binding protein subunit 1, 80 kDa nuclear cap-binding protein, NCBP 80 kDa subunit, nuclear cap binding protein subunit 1, 80kDa
Species: human
Products:     NCBP1

Top Publications

  1. Calero G, Wilson K, Ly T, Rios Steiner J, Clardy J, Cerione R. Structural basis of m7GpppG binding to the nuclear cap-binding protein complex. Nat Struct Biol. 2002;9:912-7 pubmed
    ..The latter consists of a CBP20 subunit, which binds the cap, and a CBP80 subunit, which ensures high-affinity cap binding. Here we report the 2...
  2. Lejeune F, Ishigaki Y, Li X, Maquat L. The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. EMBO J. 2002;21:3536-45 pubmed
    ..Both Upf proteins are detected on mRNA bound by the major nuclear cap-binding proteins CBP80/CBP20 but not mRNA bound by the major cytoplasmic cap-binding protein eIF4E...
  3. Mazza C, Ohno M, Segref A, Mattaj I, Cusack S. Crystal structure of the human nuclear cap binding complex. Mol Cell. 2001;8:383-96 pubmed
    ..The 2A crystal structure of human CBC shows that the large subunit, CBP80, comprises three domains, each containing consecutive helical hairpins and resembling the so-called MIF4G domain ..
  4. Balatsos N, Nilsson P, Mazza C, Cusack S, Virtanen A. Inhibition of mRNA deadenylation by the nuclear cap binding complex (CBC). J Biol Chem. 2006;281:4517-22 pubmed
    ..We showed that CBC, via its 80-kDa subunit (CBP80), inhibited PARN, suggesting that CBC can regulate mRNA deadenylation...
  5. Izaurralde E, Lewis J, McGuigan C, Jankowska M, Darzynkiewicz E, Mattaj I. A nuclear cap binding protein complex involved in pre-mRNA splicing. Cell. 1994;78:657-68 pubmed
    ..Purified CBC consists of two previously identified proteins, CBP80 and CBP20...
  6. Cheng H, Dufu K, Lee C, Hsu J, Dias A, Reed R. Human mRNA export machinery recruited to the 5' end of mRNA. Cell. 2006;127:1389-400 pubmed
    ..Both TREX recruitment and mRNA export require the cap, and these roles for the cap are splicing dependent. CBP80, which is bound to the cap, associates efficiently with TREX, and Aly mediates this interaction...
  7. Rufener S, Mühlemann O. eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells. Nat Struct Mol Biol. 2013;20:710-7 pubmed publisher
    ..These results corroborate an emerging unified model for NMD substrate recognition, according to which NMD can ensue at every aberrant translation termination event. ..
  8. Maquat L. Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics. Nat Rev Mol Cell Biol. 2004;5:89-99 pubmed
    ..Complex-loaded mRNA is thought to undergo a pioneer round of translation when still bound by cap-binding proteins CBP80 and CBP20 and poly(A)-binding protein 2...
  9. Flaherty S, Fortes P, Izaurralde E, Mattaj I, Gilmartin G. Participation of the nuclear cap binding complex in pre-mRNA 3' processing. Proc Natl Acad Sci U S A. 1997;94:11893-8 pubmed
    ..The data provides further support for the hypothesis that pre-mRNAs and mRNAs may exist and be functional in the form of "closed-loops," due to interactions between factors bound at their 5' and 3' ends. ..

More Information

Publications69

  1. Wilson K, Fortes P, Singh U, Ohno M, Mattaj I, Cerione R. The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction. J Biol Chem. 1999;274:4166-73 pubmed
    ..The CBC represents a 20- and 80-kDa heterodimer (the subunits independently referred to as CBP20 and CBP80, respectively) that binds the 7-methylguanosine cap on RNAs transcribed by RNA polymerase II...
  2. Ohno M, Segref A, Bachi A, Wilm M, Mattaj I. PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation. Cell. 2000;101:187-98 pubmed
    ..PHAX phosphorylation is essential for export complex assembly while its dephosphorylation causes export complex disassembly. The compartmentalized PHAX phosphorylation cycle can contribute to the directionality of export. ..
  3. Wilson K, Wu W, Cerione R. Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex. J Biol Chem. 2000;275:37307-10 pubmed
    ..S6 kinase may directly target the CBC in vivo as it can phosphorylate the 80-kDa subunit of the CBC, CBP80, at residues that are subject to a growth factor-dependent and rapamycin-sensitive phosphorylation in vivo...
  4. Segref A, Mattaj I, Ohno M. The evolutionarily conserved region of the U snRNA export mediator PHAX is a novel RNA-binding domain that is essential for U snRNA export. RNA. 2001;7:351-60 pubmed
    ..The interaction domain of PHAX with CBC is at least partly distinct from the RNA-binding domain and the NLSs. Thus, the different interaction domains of PHAX allow it to act as a scaffold for the assembly of U snRNA export complexes. ..
  5. Mazza C, Segref A, Mattaj I, Cusack S. Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex. EMBO J. 2002;21:5548-57 pubmed
    ..the ligand and within the subunit, as well as new interactions of the CBP20 N-terminal tail with the large subunit CBP80. Although the structure is very different from that of other known cap-binding proteins, such as the cytoplasmic ..
  6. Hwang J, Sato H, Tang Y, Matsuda D, Maquat L. UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps. Mol Cell. 2010;39:396-409 pubmed publisher
    ..round involves newly synthesized mRNA that is bound at its 5' end by the cap-binding protein (CBP) heterodimer CBP80-CBP20...
  7. Ishigaki Y, Li X, Serin G, Maquat L. Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. Cell. 2001;106:607-17 pubmed
    ..We used antibody to the nuclear cap binding protein CBP80 or its cytoplasmic counterpart eIF4E to immunopurify RNP containing nonsense-free or nonsense-containing ..
  8. Kim K, Cho H, Choi K, Kim J, Kim B, Ko Y, et al. A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation. Genes Dev. 2009;23:2033-45 pubmed publisher
    ..complex (NPC) in mammalian cells, mRNAs undergo translation mediated by nuclear cap-binding proteins 80 and 20 (CBP80/20)...
  9. Krastev D, Pettitt S, Campbell J, Song F, Tanos B, Stoynov S, et al. Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets. Nat Commun. 2018;9:2016 pubmed publisher
    ..This identifies CTIF (CBP80/CBP20-dependent translation initiation factor) as a novel PARylation target of the tankyrase enzymes in the ..
  10. Lebaron C, Rosado A, Sauvage C, Gauffier C, German Retana S, Moury B, et al. A new eIF4E1 allele characterized by RNAseq data mining is associated with resistance to potato virus Y in tomato albeit with a low durability. J Gen Virol. 2016;97:3063-3072 pubmed publisher
    ..encoding translation initiation factors [eIF4E1 and eIF4E2, eIFiso4E and the related gene new cap-binding protein(nCBP)] to look for new potential resistance alleles to potyviruses...
  11. Elmariah S, Delaney J, O Brien K, Budoff M, Vogel Claussen J, Fuster V, et al. Bisphosphonate Use and Prevalence of Valvular and Vascular Calcification in Women MESA (The Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol. 2010;56:1752-9 pubmed publisher
    the aim of this study was to determine whether nitrogen-containing bisphosphonate (NCBP) therapy is associated with the prevalence of cardiovascular calcification...
  12. Gromadzka A, Steckelberg A, Singh K, Hofmann K, Gehring N. A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs. Nucleic Acids Res. 2016;44:2348-61 pubmed publisher
    ..WxHD) in an unstructured region of ALYREF reduced RNA binding and abolished the interaction with eIF4A3 and CBP80. Additionally, the mutation impaired proper localization to nuclear speckles and export of a spliced reporter mRNA...
  13. Ryu I, Kim Y. Translation initiation mediated by nuclear cap-binding protein complex. BMB Rep. 2017;50:186-193 pubmed
    ..translation of mRNAs is initiated by two distinct mechanisms: cap-binding complex (CBC; a heterodimer of CBP80 and 20)-dependent translation (CT) and eIF4E-dependent translation (ET)...
  14. Harrison S, Lewis S, Hall A, Vuckovic D, Girotto G, Martin R, et al. Association of SNPs in LCP1 and CTIF with hearing in 11 year old children: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort and the G-EAR consortium. BMC Med Genomics. 2015;8:48 pubmed publisher
    ..Two SNPs approached sample-wide significance (pre-specified at p = 0.00014): rs12959910 in CBP80/20-dependent translation initiation factor (CTIF) for averaged high frequency hearing (p = 0...
  15. Popova V, Glukhova A, Georgieva S, Georgiev G, Kopytova D. [Interactions of the TREX-2 complex with mRNP particle of ?-tubulin 56D gene]. Mol Biol (Mosk). 2016;50:1030-1038 pubmed publisher
    ..The capping protein Cbp80 reacted both with the cap structure and with a specific part of the coding mRNA of the ?-tubulin 56D gene...
  16. Wyrzykowska A, Pieczynski M, Szweykowska Kulinska Z. Construction of Artificial miRNAs to Prevent Drought Stress in Solanum tuberosum. Methods Mol Biol. 2016;1398:271-90 pubmed publisher
    ..Here, we describe the silencing of the CBP80/ABH1 gene in Solanum tuberosum with the use of amiRNA...
  17. Decker L, Xiao H, Boone E, Vierling M, Shanker B, Kingston S, et al. The Nuclear Cap-Binding Complex Mediates Meiotic Silencing by Unpaired DNA. G3 (Bethesda). 2017;7:1149-1155 pubmed publisher
    ..Made up of cap-binding proteins CBP20 and CBP80, CBC associates with the 5' cap of mRNA transcripts in eukaryotes...
  18. Takahashi M, Saenko V, Rogounovitch T, Kawaguchi T, Drozd V, Takigawa Imamura H, et al. The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl. Hum Mol Genet. 2010;19:2516-23 pubmed publisher
  19. Chi B, Wang Q, Wu G, Tan M, Wang L, Shi M, et al. Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA. Nucleic Acids Res. 2013;41:1294-306 pubmed publisher
    ..Both Aly and THO function in linking UAP56 to the cap-binding protein CBP80. Interestingly, association of UAP56 with the spliced mRNA, but not with the pre-mRNA, requires Aly and THO...
  20. Geißler V, Altmeyer S, Stein B, Uhlmann Schiffler H, Stahl H. The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA. Nucleic Acids Res. 2013;41:7875-88 pubmed publisher
    ..For NMD triggering, the adenosine triphosphate-binding activity of Ddx5 and the 3'-untranslated region of substrate mRNAs are essential. ..
  21. Chadwick B, Obermayr F, Frischauf A. Nuclear cap binding protein maps close to the xeroderma pigmentosum complementation group A (XPA) locus in human and mouse. Genomics. 1996;35:632-3 pubmed
  22. Martin F, Schaller A, Eglite S, Schumperli D, Muller B. The gene for histone RNA hairpin binding protein is located on human chromosome 4 and encodes a novel type of RNA binding protein. EMBO J. 1997;16:769-78 pubmed
    ..In addition, recombinant HBP expressed in S. cerevisiae was functional in histone pre-mRNA processing, confirming that we have indeed identified the human HBP gene. ..
  23. Hosoda N, Kim Y, Lejeune F, Maquat L. CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells. Nat Struct Mol Biol. 2005;12:893-901 pubmed
    ..RNA decay (NMD) targets newly synthesized nonsense-containing mRNA bound by the cap-binding-protein heterodimer CBP80-CBP20 and at least one exon-junction complex (EJC)...
  24. Marintchev A, Wagner G. eIF4G and CBP80 share a common origin and similar domain organization: implications for the structure and function of eIF4G. Biochemistry. 2005;44:12265-72 pubmed
    ..Here, we present evidence that eIF4G and the large subunit of the nuclear cap-binding complex, CBP80, share a common origin and domain structure...
  25. Aguilera A. Cotranscriptional mRNP assembly: from the DNA to the nuclear pore. Curr Opin Cell Biol. 2005;17:242-50 pubmed
    ..New findings suggest that mRNP assembly is a genetically controlled process that plays a key role in gene expression and other cellular processes, including the maintenance of genome integrity. ..
  26. Gebhardt A, Habjan M, Benda C, Meiler A, Haas D, Hein M, et al. mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3. Nat Commun. 2015;6:8192 pubmed publisher
    ..The cap-binding complex (CBC), consisting of the nuclear cap-binding protein (NCBP) 2 and its adaptor NCBP1, is believed to bind all capped RNA and to be necessary for its processing and intracellular localization...
  27. Gamberi C, Izaurralde E, Beisel C, Mattaj I. Interaction between the human nuclear cap-binding protein complex and hnRNP F. Mol Cell Biol. 1997;17:2587-97 pubmed
    hnRNP F was identified in a screen for proteins that interact with human CBP80 and CBP20, the components of the nuclear cap-binding complex (CBC)...
  28. Kroczynska B, Mehrotra S, Majchrzak Kita B, Arslan A, Altman J, Stein B, et al. Regulatory effects of SKAR in interferon ? signaling and its role in the generation of type I IFN responses. Proc Natl Acad Sci U S A. 2014;111:11377-82 pubmed publisher
    ..Our studies also establish that SKAR is present in cap-binding CBP80 immune complexes and that this interaction is mediated by eIF4G...
  29. Choe J, Ahn S, Kim Y. The mRNP remodeling mediated by UPF1 promotes rapid degradation of replication-dependent histone mRNA. Nucleic Acids Res. 2014;42:9334-49 pubmed publisher
    ..The interaction between a CBP80/20-dependent translation initiation factor (CTIF) and SLBP, which is important for efficient histone mRNA ..
  30. Rashpa R, Vazquez Pianzola P, Colombo M, Hernández G, Beuchle D, Berger F, et al. Cbp80 is needed for the expression of piRNA components and piRNAs. PLoS ONE. 2017;12:e0181743 pubmed publisher
    Cap binding protein 80 (Cbp80) is the larger subunit of the nuclear cap-binding complex (nCBC), which is known to play important roles in nuclear mRNA processing, export, stability and quality control events...
  31. Ma X, Yoon S, Richardson C, Jülich K, Blenis J. SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Cell. 2008;133:303-13 pubmed publisher
    ..Thus, SKAR-mediated recruitment of activated S6K1 to newly processed mRNPs serves as a conduit between mTOR checkpoint signaling and the pioneer round of translation when cells exist in conditions supportive of protein synthesis. ..
  32. Kataoka N, Ohno M, Kangawa K, Tokoro Y, Shimura Y. Cloning of a complementary DNA encoding an 80 kilodalton nuclear cap binding protein. Nucleic Acids Res. 1994;22:3861-5 pubmed
    ..We have previously identified and purified an 80kD Nuclear Cap Binding Protein (NCBP) from a HeLa cell nuclear extract, which could possibly mediate these nuclear activities...
  33. Ohno M, Kataoka N, Shimura Y. A nuclear cap binding protein from HeLa cells. Nucleic Acids Res. 1990;18:6989-95 pubmed
    ..The purified protein shows molecular weight of 80 kilodaltons, as judged by SDS gel electrophoresis, and binds specifically to the cap structure. ..
  34. Lejeune F, Ranganathan A, Maquat L. eIF4G is required for the pioneer round of translation in mammalian cells. Nat Struct Mol Biol. 2004;11:992-1000 pubmed
    Nonsense-mediated mRNA decay (NMD) in mammalian cells targets cap-binding protein 80 (CBP80)-bound mRNA during or after a pioneer round of translation...
  35. Boulon S, Verheggen C, Jady B, Girard C, Pescia C, Paul C, et al. PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli. Mol Cell. 2004;16:777-87 pubmed
    ..Our data indicate that the role of PHAX in determining the identity of small RNAs extends to nonexported species, and this appears critical to promote their transport within the nucleus. ..
  36. Kim Y, Furic L, DesGroseillers L, Maquat L. Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay. Cell. 2005;120:195-208 pubmed
    ..We discuss this pathway as a means for cells to downregulate the expression of Stau1 binding transcripts...
  37. Izaurralde E, Lewis J, Gamberi C, Jarmolowski A, McGuigan C, Mattaj I. A cap-binding protein complex mediating U snRNA export. Nature. 1995;376:709-12 pubmed
    ..whereas the effect on pre-mRNA splicing involves a nuclear complex (CBC) composed of two cap binding proteins, CBP80 and CBP20. A role for CBC in the nuclear export of capped RNAs has also been proposed...
  38. Kim K, Cho H, Kim Y. The upstream open reading frame of cyclin-dependent kinase inhibitor 1A mRNA negatively regulates translation of the downstream main open reading frame. Biochem Biophys Res Commun. 2012;424:469-75 pubmed publisher
    ..on mRNAs bound by nuclear cap-binding complex (CBC), which is composed of nuclear cap-binding protein 80 and 20 (CBP80/20)...
  39. Pabis M, Neufeld N, Steiner M, Bojic T, Shav Tal Y, Neugebauer K. The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells. RNA. 2013;19:1054-63 pubmed publisher
    ..Taken together, the data support a model whereby CBC promotes pre-mRNA splicing through a network of interactions with and among spliceosomal snRNPs during cotranscriptional spliceosome assembly. ..
  40. Morris C, Wittmann J, Jack H, Jalinot P. Human INT6/eIF3e is required for nonsense-mediated mRNA decay. EMBO Rep. 2007;8:596-602 pubmed
    ..Consistent with such a role, immunoprecipitation experiments showed that INT6 co-purifies with CBP80 and the NMD factor UPF2...
  41. Kataoka N, Ohno M, Moda I, Shimura Y. Identification of the factors that interact with NCBP, an 80 kDa nuclear cap binding protein. Nucleic Acids Res. 1995;23:3638-41 pubmed
    ..As a candidate for the factor involved in these nuclear events we have previously purified an 80 kDa nuclear cap binding protein (NCBP) from a HeLa cell nuclear extract and isolated its full-length cDNA...
  42. Wang Y, Zhang S, Huang F, Zhou X, Chen Z, Peng W, et al. VirD5 is required for efficient Agrobacterium infection and interacts with Arabidopsis VIP2. New Phytol. 2017;: pubmed publisher
    ..Further experiments demonstrated that VirD5 can affect VIP2 binding to cap-binding proteins (CBP20 and CBP80)...
  43. Shi M, Zhang H, Wu X, He Z, Wang L, Yin S, et al. ALYREF mainly binds to the 5' and the 3' regions of the mRNA in vivo. Nucleic Acids Res. 2017;45:9640-9653 pubmed publisher
    ..Consistent with previous in vitro studies, ALYREF binds to a region near the 5' end of the mRNA in a CBP80-dependent manner. Unexpectedly, we identified PABPN1-dependent ALYREF binding near the 3' end of the mRNA...
  44. Dankert J, Pagan J, Starostina N, Kipreos E, Pagano M. FEM1 proteins are ancient regulators of SLBP degradation. Cell Cycle. 2017;16:556-564 pubmed publisher
    ..elegans results in the upregulation of SLBP ortholog CDL-1 in oocytes. Notably, cyclin F is absent in flies and worms, suggesting that FEM1 proteins play an important role in SLBP targeting in lower eukaryotes. ..
  45. Bokar J, Shambaugh M, Polayes D, Matera A, Rottman F. Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. RNA. 1997;3:1233-47 pubmed
    ..MT-A70 also contains a long region of homology to the yeast protein SPO8, which is involved in induction of sporulation by an unknown mechanism. ..
  46. McKendrick L, Thompson E, Ferreira J, Morley S, Lewis J. Interaction of eukaryotic translation initiation factor 4G with the nuclear cap-binding complex provides a link between nuclear and cytoplasmic functions of the m(7) guanosine cap. Mol Cell Biol. 2001;21:3632-41 pubmed
    ..The nuclear cap-binding complex (CBC; consisting of CBP20 and CBP80) mediates the stimulatory functions of the cap in pre-mRNA splicing, 3' end formation, and U snRNA export...
  47. Dankert J, Róna G, Clijsters L, Geter P, Skaar J, Bermudez Hernandez K, et al. Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2. Mol Cell. 2016;64:507-519 pubmed publisher
    ..We propose that cyclin F co-evolved with the appearance of stem-loops in vertebrate H2AFX mRNA to mediate SLBP degradation, thereby limiting H2A.X synthesis and cell death upon genotoxic stress. ..
  48. Dias S, Wilson K, Rojas K, Ambrosio A, Cerione R. The molecular basis for the regulation of the cap-binding complex by the importins. Nat Struct Mol Biol. 2009;16:930-7 pubmed publisher
    ..structure for a CBC-importin-alpha complex that provides a detailed picture for how importin-alpha binds to the CBP80 subunit of the CBC...
  49. Woeller C, Gaspari M, Isken O, Maquat L. NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA. EMBO Rep. 2008;9:446-51 pubmed publisher
    ..NMD in mammalian cells targets newly spliced mRNA that is bound by the cap-binding protein heterodimer CBP80/20 and one or more post-splicing exon junction complexes during a pioneer round of translation...
  50. Boyne J, Colgan K, Whitehouse A. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. PLoS Pathog. 2008;4:e1000194 pubmed publisher
    ..Together, these data provide the first direct evidence that the complete hTREX complex is essential for the export of KSHV intronless mRNAs and infectious virus production. ..
  51. Choe J, Oh N, Park S, Lee Y, Song O, Locker N, et al. Translation initiation on mRNAs bound by nuclear cap-binding protein complex CBP80/20 requires interaction between CBP80/20-dependent translation initiation factor and eukaryotic translation initiation factor 3g. J Biol Chem. 2012;287:18500-9 pubmed publisher
    In the cytoplasm of mammalian cells, either cap-binding proteins 80 and 20 (CBP80/20) or eukaryotic translation initiation factor (eIF) 4E can direct the initiation of translation...
  52. Maquat L, Hwang J, Sato H, Tang Y. CBP80-promoted mRNP rearrangements during the pioneer round of translation, nonsense-mediated mRNA decay, and thereafter. Cold Spring Harb Symp Quant Biol. 2010;75:127-34 pubmed publisher
    ..Newly synthesized mRNPs bound by the cap-binding protein heterodimer CBP80-CBP20 (CBC) initially undergo a pioneer round of translation...
  53. Yamashita A, Izumi N, Kashima I, Ohnishi T, Saari B, Katsuhata Y, et al. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev. 2009;23:1091-105 pubmed publisher
  54. Cevher M, Zhang X, Fernandez S, Kim S, Baquero J, Nilsson P, et al. Nuclear deadenylation/polyadenylation factors regulate 3' processing in response to DNA damage. EMBO J. 2010;29:1674-87 pubmed publisher
    ..deadenylation by PARN in the presence of CstF-50, and that CstF-50/BARD1 can revert the cap-binding protein-80 (CBP80)-mediated inhibition of PARN activity...
  55. Narita T, Yung T, Yamamoto J, Tsuboi Y, Tanabe H, Tanaka K, et al. NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs. Mol Cell. 2007;26:349-65 pubmed
    ..Our results point to a surprising role of NELF in the 3' end processing of histone mRNAs and also suggest that NELF is a new factor that coordinates different mRNA processing steps during transcription. ..
  56. Yong J, Wan L, Dreyfuss G. Why do cells need an assembly machine for RNA-protein complexes?. Trends Cell Biol. 2004;14:226-32 pubmed
    ..We discuss how this surveillance capacity of the SMN complex might ensure assembly of Sm cores only on the correct RNAs and prevent illicit, potentially deleterious assembly of Sm cores on random RNAs. ..
  57. Matsuda D, Hosoda N, Kim Y, Maquat L. Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA. Nat Struct Mol Biol. 2007;14:974-9 pubmed
    ..In mammals, NMD seems to be restricted to newly synthesized mRNA that is bound by the cap-binding heterodimer CBP80-CBP20 (CBP80/20) and typically has at least one exon junction complex (EJC) situated downstream of the nonsense ..
  58. Meola N, Domanski M, Karadoulama E, Chen Y, Gentil C, Pultz D, et al. Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts. Mol Cell. 2016;64:520-533 pubmed publisher
    ..Importantly, ZFC3H1/PABPN1 and ZCCHC8/RBM7 contact hMTR4 in a mutually exclusive manner, revealing that the exosome targets nuclear transcripts of different maturation status by substituting its hMTR4-associating adaptors. ..
  59. Bier K, York A, Fodor E. Cellular cap-binding proteins associate with influenza virus mRNAs. J Gen Virol. 2011;92:1627-34 pubmed publisher
    ..with the viral non-structural protein 1 (NS1), cellular poly(A)-binding protein 1 (PABP1), the 20 kDa subunit NCBP1 of the nuclear cap-binding complex (CBC), the RNA and export factor-binding protein REF/Aly and the translation ..
  60. Worch R, Jankowska Anyszka M, Niedzwiecka A, Stepinski J, Mazza C, Darzynkiewicz E, et al. Diverse role of three tyrosines in binding of the RNA 5' cap to the human nuclear cap binding complex. J Mol Biol. 2009;385:618-27 pubmed publisher
    ..The resulting kinetic model of the association between the capped RNA and CBC, based on the experimental data and quantum calculations, is discussed with respect to the "CBC-to-eukaryotic initiation factor 4E handoff" of mRNA. ..