NAT6

Summary

Gene Symbol: NAT6
Description: N-acetyltransferase 6 (GCN5-related)
Alias: FUS-2, FUS2, N-acetyltransferase 6, protein fusion-2
Species: human

Top Publications

  1. ncbi The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium
    M I Lerman
    Laboratory of Immanobiology, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA
    Cancer Res 60:6116-33. 2000
  2. ncbi Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas
    Paulisally Hau Yi Lo
    Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, People s Republic of China
    Cancer Lett 234:184-92. 2006
  3. ncbi Familial partial monosomy 7 and myelodysplasia: different parental origin of the monosomy 7 suggests action of a mutator gene
    A Minelli
    Biologia Generale e Genetica Medica, , C.P. 217, I 27100, Pavia, Italy
    Cancer Genet Cytogenet 124:147-51. 2001
  4. ncbi [Detailed mapping and clinical significance of loss of heterozygosity on 9p13-23 in laryngeal squamous cell carcinoma by microsatellite analysis]
    Xian fa Xu
    Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing, PR China
    Ai Zheng 22:452-7. 2003
  5. ncbi Transcriptional repression mediated by the WT1 Wilms tumor gene product
    S L Madden
    Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104
    Science 253:1550-3. 1991
  6. pmc Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein
    Hansoo Lee
    Department of Pathology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    Mol Cell Biol 27:2103-19. 2007
  7. ncbi beta-carotene-induced changes in RARbeta isoform mRNA expression patterns do not influence lung adenoma multiplicity in the NNK-initiated A/J mouse model
    Regina Goralczyk
    DSM Nutritional Products Ltd, Research and Development, Human Nutrition and Health, Basel, Switzerland
    Nutr Cancer 54:252-62. 2006
  8. ncbi Allelotyping in mycosis fungoides and Sézary syndrome: common regions of allelic loss identified on 9p, 10q, and 17p
    J J Scarisbrick
    Skin Tumour Unit, St John s Institute Dermatology, St Thomas Hospital, London, UK
    J Invest Dermatol 117:663-70. 2001
  9. ncbi ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways
    Michele A Battle
    Carcinogenesis Laboratory, Cell and Molecular Biology Program, Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 1302, USA
    Biochemistry 42:7270-82. 2003
  10. ncbi Screening and identification of down-regulated genes in colorectal carcinoma by subtractive hybridization: a method to identify putative tumor suppressor genes
    S Zheng
    Cancer Institute, Zhejiang Medical University, Hangzhou, China
    Chin Med J (Engl) 110:543-7. 1997

Research Grants

Detail Information

Publications185 found, 100 shown here

  1. ncbi The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium
    M I Lerman
    Laboratory of Immanobiology, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA
    Cancer Res 60:6116-33. 2000
    ..of the genes to have two or more amino acid sequence-altering mutations including BLU, NPRL2/Gene21, FUS1, HYAL1, FUS2, and SEMA3B...
  2. ncbi Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas
    Paulisally Hau Yi Lo
    Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, People s Republic of China
    Cancer Lett 234:184-92. 2006
    The expression of six chromosome 3p21.3 candidate tumor suppressor genes (BLU, FUS2, HYAL2, NPRL2, RASSF1A, and SEMA3B) in esophageal squamous cell carcinoma (ESCC) has been investigated...
  3. ncbi Familial partial monosomy 7 and myelodysplasia: different parental origin of the monosomy 7 suggests action of a mutator gene
    A Minelli
    Biologia Generale e Genetica Medica, , C.P. 217, I 27100, Pavia, Italy
    Cancer Genet Cytogenet 124:147-51. 2001
    ..We postulate that, in fact, an inherited mutation in any of a group of mutator genes causes familial monosomy 7 also in the absence of a recognized mendelian disease, and that marrow chromosome 7 anomalies, in turn, lead to MDS/AML...
  4. ncbi [Detailed mapping and clinical significance of loss of heterozygosity on 9p13-23 in laryngeal squamous cell carcinoma by microsatellite analysis]
    Xian fa Xu
    Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing, PR China
    Ai Zheng 22:452-7. 2003
    ..This study was designed to refine the hot spots of LOH on 9p13-23 in laryngeal squamous cell carcinoma and compare the correlation between the incidence of microsatellite LOH and the clinicopathological parameters...
  5. ncbi Transcriptional repression mediated by the WT1 Wilms tumor gene product
    S L Madden
    Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104
    Science 253:1550-3. 1991
    ..The repression function was mapped to the glutamine- and proline-rich NH2-terminus of WT1; fusion of this domain to the zinc finger region of EGR-1 converted EGR-1 into a transcriptional repressor...
  6. pmc Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein
    Hansoo Lee
    Department of Pathology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    Mol Cell Biol 27:2103-19. 2007
    ..Collectively, these findings indicate that NGB is a tumor suppressor that regulates and requires merlin to suppress cell proliferation...
  7. ncbi beta-carotene-induced changes in RARbeta isoform mRNA expression patterns do not influence lung adenoma multiplicity in the NNK-initiated A/J mouse model
    Regina Goralczyk
    DSM Nutritional Products Ltd, Research and Development, Human Nutrition and Health, Basel, Switzerland
    Nutr Cancer 54:252-62. 2006
    ..Down-regulation of RARbeta in NNK-induced adenoma-bearing lungs was similar to that observed in human lung cancer and further confirms the A/J-mouse as a valuable model for lung carcinogenesis...
  8. ncbi Allelotyping in mycosis fungoides and Sézary syndrome: common regions of allelic loss identified on 9p, 10q, and 17p
    J J Scarisbrick
    Skin Tumour Unit, St John s Institute Dermatology, St Thomas Hospital, London, UK
    J Invest Dermatol 117:663-70. 2001
    ..These results provide the basis for further studies defining more accurately chromosomal regions of deletions and candidate tumor suppressor genes involved in mycosis fungoides and Sézary syndrome...
  9. ncbi ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways
    Michele A Battle
    Carcinogenesis Laboratory, Cell and Molecular Biology Program, Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 1302, USA
    Biochemistry 42:7270-82. 2003
    ..Clearly, ST7 is an LRP, and therefore, it should now be referred to as LRP12...
  10. ncbi Screening and identification of down-regulated genes in colorectal carcinoma by subtractive hybridization: a method to identify putative tumor suppressor genes
    S Zheng
    Cancer Institute, Zhejiang Medical University, Hangzhou, China
    Chin Med J (Engl) 110:543-7. 1997
    ..To search for new putative tumor suppressor genes in colorectal carcinoma...
  11. pmc Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis
    Timothy A Chan
    Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America
    PLoS Med 5:e114. 2008
    ..We hypothesize that key tumor suppressor genes in cancer may be subject to mutation or hypermethylation...
  12. ncbi mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells
    Li Hui
    Department of Biological Sciences, Hunter College of the City University of New York, New York, New York 10021, USA
    J Biol Chem 280:35829-35. 2005
    ..The ability of phospholipase D to suppress protein phosphatase 2A identifies a critical target of an emerging phospholipase D/mTOR survival pathway in the transformation of human cells...
  13. pmc Fus2 localizes near the site of cell fusion and is required for both cell fusion and nuclear alignment during zygote formation
    E A Elion
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    J Cell Biol 130:1283-96. 1995
    ..Genetic evidence suggests that the FUS2 gene product promotes cell fusion during zygote formation in Saccharomyces cerevisiae, functioning with the Fus1 ..
  14. ncbi A retinoic acid receptor beta/gamma-selective prodrug (tazarotene) plus a retinoid X receptor ligand induces extracellular signal-regulated kinase activation, retinoblastoma hypophosphorylation, G0 arrest, and cell differentiation
    Andrew Yen
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Mol Pharmacol 66:1727-37. 2004
    ..Tazarotene used with RXR-selective ligand may thus be a useful antineoplastic agent in differentiation induction therapy as exemplified by the prototypical RA treatment of acute promyelocytic leukemia...
  15. pmc Merlin knockdown in human Schwann cells: clues to vestibular schwannoma tumorigenesis
    Zana Ahmad
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of California San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, U S A
    Otol Neurotol 31:460-6. 2010
    ..To investigate the early events in molecular progression toward schwannoma tumorigenesis, we developed an in vitro model of human Schwann cell tumorigenesis by merlin knockdown...
  16. ncbi Frequent loss of heterozygosity at the 19p13.3 locus without LKB1/STK11 mutations in human carcinoma metastases to the brain
    S B Sobottka
    Department of Neurosurgery, Technical University of Dresden, Germany
    J Neurooncol 49:187-95. 2000
    ..Based on these findings, the genes adjacent to LKB1/STK11 may be relevant for the development of metastases to the brain from certain carcinomas...
  17. ncbi Frequent occurrence of Ha-rasl allelic deletion in human ovarian adenocarcinomas
    A Viel
    Division of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano, Pordenone, Italy
    Tumori 77:16-20. 1991
    ..These findings may suggest that a putative tumor suppressor gene closely linked to Ha-rasl in 11p15.5 is involved in ovarian cancerogenesis...
  18. ncbi Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas
    Javier Silva
    Department of Medical Oncology, Hospital Universitario Puerta de Hierro, c San Martin de Porres, E 28035 Madrid, Spain
    Mutat Res 594:78-85. 2006
    ..Future and larger series studies in different tumor types are necessary to clarify Ris-1 function in human cancer...
  19. ncbi Diminished levels of the putative tumor suppressor proteins EXT1 and EXT2 in exostosis chondrocytes
    M A Bernard
    Department of Pediatrics, University of Texas Houston Medical School, Houston, Texas 77225 0708, USA
    Cell Motil Cytoskeleton 48:149-62. 2001
    ..These results suggest that multiple mutational steps are involved in exostosis development and that EXT genes play a role in cell signaling related to chondrocyte cytoskeleton regulation...
  20. pmc Down-regulation of SFRP1 as a putative tumor suppressor gene can contribute to human hepatocellular carcinoma
    Jian Huang
    Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China
    BMC Cancer 7:126. 2007
    ..However, whether the down-regulation of SFRP1 can contribute to hepatocarcinogenesis still remains unclear...
  21. ncbi Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration
    Yonghe Li
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, Missouri 63110, USA
    J Biol Chem 277:42366-71. 2002
    ..Taken together, these results demonstrate that LRP1B can function as a negative regulator of uPAR regeneration and cell migration...
  22. ncbi The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production
    Judy A Cam
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:29639-46. 2004
    ..These findings reveal that LRP1B is a novel binding partner of APP that functions to decrease APP processing to Abeta. Consequently LRP1B expression could function to protect against the pathogenesis of Alzheimer's disease...
  23. ncbi Inhibition of growth by p205: a nuclear protein and putative tumor suppressor expressed during myeloid cell differentiation
    Jonathan M Dermott
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702 1201, USA
    Stem Cells 22:832-48. 2004
    ..We propose that during myelomonocytic cell differentiation, induction of p205 expression contributes to cell growth arrest, thus allowing progenitor cells to differentiate...
  24. pmc Slow endocytosis of the LDL receptor-related protein 1B: implications for a novel cytoplasmic tail conformation
    Jane M Knisely
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Cell Res 313:3298-307. 2007
    ..From these data, we propose that both halves of the LRP1B cytoplasmic tail contribute to a unique global conformation, which results in less efficient recognition by endocytic adaptors and a slow endocytosis rate...
  25. ncbi Loss of heterozygosity on chromosome 22q in gastrointestinal stromal tumors (GISTs): a study on 50 cases
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Lab Invest 85:237-47. 2005
    ..An isolated LOH at D22S425 was equally found in both benign and malignant tumors. These observations may suggest that LOHs on chromosome 22q in GISTs play a role in early stages of tumor formation as well as in late tumor progression...
  26. pmc Microdissecting the genetic events in nephrogenic rests and Wilms' tumor development
    A K Charles
    Department of Pediatric Pathology, St Michael s Hospital, Bristol, United Kingdom
    Am J Pathol 153:991-1000. 1998
    ..Intralobar and perilobar nephrogenic rests are known to have different biological behaviors, and this study suggests that they are genetically different. A multistep model of Wilms' tumor pathogenesis is supported by these findings...
  27. ncbi Non-linkage of familial rhabdoid tumors to SMARCB1 implies a second locus for the rhabdoid tumor predisposition syndrome
    Michael C Frühwald
    University Children s Hospital Muenster, Department of Paediatric Haematology and Oncology, Muenster, Germany
    Pediatr Blood Cancer 47:273-8. 2006
    ..2. Several familial cases have been published and summarized under the term rhabdoid tumor predisposition syndrome. In all of the published familial cases, inactivation of SMARCB1 was detected in tumor tissues...
  28. pmc Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer
    Ruben Agrelo
    Cancer Epigenetics Laboratory, Spanish National Cancer Centre, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 103:8822-7. 2006
    ..These findings highlight the importance of WRN epigenetic inactivation in human cancer, leading to enhanced chromosomal instability and hypersensitivity to chemotherapeutic drugs...
  29. ncbi Low expression of reduced folate carrier-1 and folylpolyglutamate synthase correlates with lack of a deleted in colorectal carcinoma mRNA splice variant in normal-appearing mucosa of colorectal carcinoma patients
    Yvonne Wettergren
    Department of General Surgery, Sahlgrenska University Hospital Ostra, Goteborg University, S 416 85 Goteborg, Sweden
    Cancer Detect Prev 29:348-55. 2005
    ..The purpose of this study was to analyze if the folate level and the gene expression levels of reduced folate carrier (RFC-1) and folylpolyglutamate synthase (FPGS) had impact on the expression of DCC splice variants...
  30. pmc Loss of the putative tumor suppressor band 4.1B/Dal1 gene is dispensable for normal development and does not predispose to cancer
    Chunling Yi
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 25:10052-9. 2005
    ..These findings indicate that the 4.1B gene is not required for normal development and that 4.1B/Dal-1 does not function as a tumor suppressor gene...
  31. ncbi Genetic analysis of childhood germ cell tumors with comparative genomic hybridization
    D T Schneider
    Clinic of Pediatric Hematology and Oncology, Heinrich Heine University, Medical Center, Dusseldorf, Germany
    Klin Padiatr 213:204-11. 2001
    ..As CGH does not require tissue culture, it also allows analysing archival tissue samples...
  32. pmc Antitumor effect of retinoic acid receptor-beta2 associated with suppression of cyclooxygenase-2
    Shumei Song
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Prev Res (Phila) 2:274-80. 2009
    ..Thus, further studies will determine whether manipulation of COX-2 expression in different cancers can antagonize RAR-beta2 activity...
  33. ncbi Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice
    R H Zurawel
    Department of Neurological Surgery, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Genes Chromosomes Cancer 28:77-81. 2000
    ..Expression of Gli1 was increased in tumors compared to normal cerebellum. These results suggest that deletion of one copy of Ptch may be sufficient to promote medulloblastoma development in mice...
  34. ncbi Genetic aberrations common in gastric high-grade large B-cell lymphoma
    P Starostik
    Institute of Pathology and Division of Medicine, Wuerzburg University, Wuerzburg, Germany
    Blood 95:1180-7. 2000
    ..Common genetic aberrations responsible for lymphomagenesis are deletions of 6q, loss of p53, and amplification of the 3q27 and the MLL gene regions. (Blood. 2000;95:1180-1187)..
  35. ncbi A dual-color FISH framework map for the characterization of the Sai1 tumor suppression region on rat chromosome 5
    K Helou
    CMB Genetics, Lundberg Laboratory, Goteborg University, Goteborg, Sweden
    Genes Chromosomes Cancer 27:362-72. 2000
    ..1) and Cd30lg (5q24.3). The framework map will provide the basis for the detailed physical YAC clone contig mapping of this region, and facilitate the identification and characterization of the Sai1 locus...
  36. ncbi Genetic modeling of human urinary bladder carcinogenesis
    B Czerniak
    Department of Pathology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Genes Chromosomes Cancer 27:392-402. 2000
    ..The approach used in this study facilitates genome-wide modeling of cancer progression and provides important chromosomal landmarks for more specific studies of multistep urinary bladder carcinogenesis...
  37. ncbi Molecular genetic parameters in pathogenesis and prognosis of testicular germ cell tumors
    A Heidenreich
    Department of Urology, Philipps University, Marburg, Germany
    Eur Urol 37:121-35. 2000
    ..and prognosis of testicular germ cell tumors will not only help to better understand development and progression of testicular cancer, but it will also define new approaches to classification and management of germ cell tumors..
  38. ncbi 3p21, 5q21, 9p21 and 17p13.1 allelic deletions are potential markers of individuals with a high risk of developing adenocarcinoma in Barrett's epithelium without dysplasia
    Julian Sanz-Ortega
    Departamento de Anatomía Patológica Hospital Clinico San Carlos, Martin Lagos s n, Madrid, Spain 28040
    Hepatogastroenterology 50:404-7. 2003
    ..We investigated 32 cases of Barrett's esophagus with no evidence of dysplasia for LOH at 5q21 (APC), 3p21, 9p21 (p16) and 17p13.1 (p53) chromosomal regions...
  39. pmc Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-beta
    O Cristina Micali
    Department of Plant Microbe Interactions, Max Planck Institute for Plant Breeding Research, Koeln, Germany
    BMC Cancer 7:52. 2007
    ..In this report, we investigated the role of basal xaf1 promoter methylation in xaf1 expression and assessed the responsiveness of cancer cell lines to XAF1 induction by IFN-beta...
  40. doi TCEAL7, a putative tumor suppressor gene, negatively regulates NF-kappaB pathway
    R Rattan
    Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Oncogene 29:1362-73. 2010
    ....
  41. doi Assessment of NORE1A as a putative tumor suppressor in human neuroblastoma
    Janos Geli
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Int J Cancer 123:389-94. 2008
    ..Promotor methylation is not a common mechanism responsible for NORE1A transcriptional suppression in this tumor type...
  42. ncbi Localization and expression of p27KIP1 in multistage colorectal carcinogenesis
    M Ciaparrone
    Centro di Ricerche Oncologicalhe Giovanni XXXIII Università Cattolica del Sacro Cuore, Rome, Italy
    Cancer Res 58:114-22. 1998
    ..This may reflect the existence of a homeostatic feedback mechanism that is lost in the high-grade carcinomas that express low levels of p27Kip1...
  43. ncbi Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene
    Violetta Barbashina
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Clin Cancer Res 11:1119-28. 2005
    ..To better define the histologic correlates of different patterns of 1p and 19q loss, we evaluated 1p/19q status in a large group of gliomas. This also allowed us to define a very small minimal deleted region (MDR) on 1p36...
  44. doi Single nucleotide polymorphisms of IGFBP-3 gene and lung cancer risk in a Korean population
    Sle Gi Lo Han
    Genomic Research Center for Lung and Breast Ovarian Cancers, Korea University Anam Hospital, Seoul, Republic of Korea
    Lung Cancer 62:152-61. 2008
    ..These results suggest that IGFBP-3 promoter polymorphisms of -1590 C>A and -202 A>C might be a genetic risk factor for lung cancer by means of decreased IGFBP-3 expression among females or never-smoking Koreans...
  45. ncbi Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma
    Tomohiro Kondo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncogene 24:157-64. 2005
    ..These results indicate that LOH of PINX1 locus and hypoacetylation of histone H4 in the 5' UTR of PINX1 are associated with reduced expression of PINX1 in GC...
  46. pmc Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation
    Franco Capozza
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Pathol 162:2029-39. 2003
    ..Our results provide the first genetic evidence that caveolin-1 indeed functions as a tumor suppressor gene in vivo...
  47. doi Hypoglycemia from IGF2 overexpression associated with activation of fetal promoters and loss of imprinting in a metastatic hemangiopericytoma
    Elizabeth A Lawson
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:2226-31. 2009
    ..The mechanism of IGF2 overexpression in non-islet-cell tumor hypoglycemia is not understood...
  48. ncbi Allelic loss of distal chromosome 4 in mouse lung tumors localize a putative tumor suppressor gene to a region homologous with human chromosome 1p36
    C R Herzog
    Department of Pathology, Medical College of Ohio, Toledo 43699, USA
    Oncogene 11:1811-5. 1995
    ..In contrast, retention of heterozygosity was observed at all markers tested in each of the adenomas studied, which suggests that the inactivation of this tumor suppressor gene participates in mouse lung tumor progression...
  49. ncbi Novel mutation in the EXT-1 gene in an Iranian family affected with hereditary multiple exostoses
    Ali Mohammad Foroughmand
    Department of Genetics, Faculty of Science, Shahid Chamran University, Ahvaz, Iran
    Pak J Biol Sci 11:1037-41. 2008
    ..This mutation leads to a premature stop codon and previously not described. Additionally, we have found an unreported silent mutation in the exon six of EXT1 gene with uncertain significance...
  50. pmc The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression
    Efrat Shema
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Genes Dev 22:2664-76. 2008
    ..Furthermore, frequent RNF20 promoter hypermethylation was observed in tumors. RNF20 may thus be a putative tumor suppressor, acting through selective regulation of a distinct subset of genes...
  51. pmc Expression of the putative tumor suppressor gene PTPN13/PTPL1 is an independent prognostic marker for overall survival in breast cancer
    Francoise Revillion
    Contrôle de la progression des cancers hormono dépendants, Laboratoire d Oncologie Moléculaire Humaine, Centre Régional de Lutte Contre le Cancer Oscar Lambret, Lille, France
    Int J Cancer 124:638-43. 2009
    ..In conjunction with our mechanistic studies, this finding identifies PTPL1 as an important regulatory element of human breast tumor aggressiveness and sensitivity to treatments such as antiestrogens and antiaromatase...
  52. pmc p53 represses c-Myc through induction of the tumor suppressor miR-145
    Mohit Sachdeva
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Proc Natl Acad Sci U S A 106:3207-12. 2009
    ....
  53. pmc Osmotic balance regulates cell fusion during mating in Saccharomyces cerevisiae
    J Philips
    Department of Biochemistry and Biophysics, Programs in Genetics and Cell Biology, San Francisco, California 94143 0448, USA
    J Cell Biol 138:961-74. 1997
    ..fusion is regulated, we identified mutants defective in cell fusion based upon their defect in mating to a fus1 fus2 strain (Chenevert, J., N. Valtz, and I. Herskowitz. 1994. Genetics 136:1287-1297)...
  54. pmc The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment
    Charlotte Rolny
    Institute for Cancer Research and Treatment IRCC, University of Turin, School of Medicine, 10060 Candiolo, Italy
    J Exp Med 205:1155-71. 2008
    ..In conclusion, we report that SEMA3B exerts unexpected functions in cancer progression by fostering a prometastatic environment through elevated IL-8 secretion and recruitment of macrophages coupled to the suppression of tumor growth...
  55. ncbi Correlation of visinin-like-protein-1 expression with clinicopathological features in squamous cell carcinoma of the esophagus
    Carla Wickborn
    Signal Transduction Research Group, Neuroscience Research Center Institute for Physiology, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Mol Carcinog 45:572-81. 2006
    ..The protein expression level significantly correlates with invasive features, such as depth of tumor invasion and local lymph node metastasis, but not with proliferation rate of tumor cells...
  56. ncbi Loss of heterozygosity in human primary prostate carcinomas: a possible tumor suppressor gene at 7q31.1
    J C Zenklusen
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Smithville 78957
    Cancer Res 54:6370-3. 1994
    ..1-31.2, confirming our previous functional evidence for a TSG at this location. Further research needs to be conducted to establish the identity and function of this putative TSG...
  57. ncbi The putative tumor suppressor Cdx2 is overexpressed by human colorectal adenocarcinomas
    Matthew E Witek
    Division of Clinical Pharmacology, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Clin Cancer Res 11:8549-56. 2005
    ..Here, Cdx2 expression and function was quantified in tumors and matched normal mucosa from patients with colorectal cancer...
  58. doi KLF10, transforming growth factor-β-inducible early gene 1, acts as a tumor suppressor
    Ki Duk Song
    Center for Agricultural Biomaterials, Seoul National University, Seoul 151 921, South Korea
    Biochem Biophys Res Commun 419:388-94. 2012
    ..This study demonstrates that KLF10 is a tumor suppressor and that it targets p21(WAF1/CIP1) transcription...
  59. ncbi Hedgehog antagonist REN(KCTD11) regulates proliferation and apoptosis of developing granule cell progenitors
    Beatrice Argenti
    Department of Experimental Medicine and Pathology, University La Sapienza, 00161 Rome, Italy
    J Neurosci 25:8338-46. 2005
    ..Medulloblastoma-associated REN loss of function might withdraw such a limiting signal for immature cell expansion, thus favoring tumorigenesis...
  60. ncbi Hypermethylation of the p15INK4B gene promoter in B-chronic lymphocytic leukemia
    Sotirios G Papageorgiou
    Second Department of Internal Medicine Propaedeutic, University General Hospital Attikon, Haidari, Greece
    Am J Hematol 82:824-5. 2007
    ..Our results suggest that methylation of the p15 gene promoter can be detected in a small subset of B-CLL patients, at all stages of the disease...
  61. ncbi A 3-Mb physical map of the chromosome region 8p21.3-p22, including a 600-kb region commonly deleted in human hepatocellular carcinoma, colorectal cancer, and non-small cell lung cancer
    Y Fujiwara
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Genes Chromosomes Cancer 10:7-14. 1994
    ..6 Mb in NSCLC. As four of the 12 physically ordered markers are located within the 0.6 Mb region commonly deleted in all three tumor types, nearly one fourth to one fifth of the target region has already been covered with cosmid inserts...
  62. ncbi Ing1 mediates p53 accumulation and chromatin modification in response to oncogenic stress
    Maria Abad
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, E 28029 Madrid, Spain
    J Biol Chem 282:31060-7. 2007
    ..Our results support an important role for the Ing1 locus in protection against oncogenic stress in vivo, both as a mediator of p53 activation and as a regulator of chromatin remodeling processes...
  63. ncbi The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers
    Stefan M Woerner
    Department of Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 220 221, D 69120 Heidelberg, Germany
    Genes Chromosomes Cancer 46:1080-9. 2007
    ....
  64. ncbi Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene
    J C Zenklusen
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Smithville 78957, USA
    Oncogene 11:359-63. 1995
    ..The high incidence of LOH in primary ovarian carcinomas suggests that a TSG relevant to the development of ovarian cancers is present at 7q31.1, confirming our previous functional evidence for a TSG in this region...
  65. doi The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2
    Jeffrey M Friedman
    Department of Urology, Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Cancer Res 69:2623-9. 2009
    ..We conclude that miR-101 may be a potent tumor suppressor by altering global chromatin structure through repression of EZH2...
  66. pmc Activator protein 2alpha suppresses intestinal tumorigenesis in the Apc(min) mouse
    Qingjie Li
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Cancer Lett 283:36-42. 2009
    ....
  67. doi Characterization of CACNA2D3 as a putative tumor suppressor gene in the development and progression of nasopharyngeal carcinoma
    Alissa Michelle Go Wong
    Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
    Int J Cancer 133:2284-95. 2013
    ..Our study also warrants further exploration in the potential therapeutic use of existing epigenetic targeting drugs (e.g., 5-azacytidine, SAHA) to reconstitute CACNA2D3-associated tumor suppression in NPC. ..
  68. pmc Stat3 inhibits PTPN13 expression in squamous cell lung carcinoma through recruitment of HDAC5
    Xiu Juan Han
    The Helmholtz Sino German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi an 710038, China
    Biomed Res Int 2013:468963. 2013
    ..Thus, our results suggest a previously unknown Stat3-PTPN13 molecular network controlling squamous cell lung carcinoma development. ..
  69. doi The role of p21(waf1/cip1) and p27(Kip1) in HDACi-mediated tumor cell death and cell cycle arrest in the Eμ-myc model of B-cell lymphoma
    A Newbold
    Cancer Therapeutics Program, Gene Regulation Laboratory, The Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria, Australia
    Oncogene 33:5415-23. 2014
    ..These data demonstrate that induction of cdkn1a does not regulate HDACi-mediated tumor cell apoptosis and refute the notion that p21(waf1/cip1) is an obligate mediator of HDACi-induced cell cycle arrest...
  70. doi The association between RASSF1A promoter methylation and prostate cancer: evidence from 19 published studies
    Yu Zheng Ge
    Department of Urology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, 210006, China
    Tumour Biol 35:3881-90. 2014
    ....
  71. pmc Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy
    Jens G Lohr
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02412, USA Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA
    Cancer Cell 25:91-101. 2014
    ..These results emphasize the importance of heterogeneity analysis for treatment decisions...
  72. pmc CMTM3 inhibits human testicular cancer cell growth through inducing cell-cycle arrest and apoptosis
    Zesong Li
    Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People s Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, China
    PLoS ONE 9:e88965. 2014
    ..CMTM3 is thus involved in testicular cancer pathogenesis, and it is frequently at least partially silenced by the methylation of a single, specific CpG site in tumor tissues. ..
  73. doi ZIC1 is a putative tumor suppressor in thyroid cancer by modulating major signaling pathways and transcription factor FOXO3a
    Wei Qiang
    Department of Endocrinology W Q, Q Y, W L, S L, B S, P H, The First Affiliated Hospital of Xi an Jiaotong University School of Medicine, Xi an 710061, China Department of Gerontology Y Z, Shaanxi Provincial People s Hospital, Xi an 710068, China Department of Endocrinology and Metabolism H G, The First Affiliated Hospital of China Medical University, Shenyang 110001, China and Center for Translational Medicine M J, The First Affiliated Hospital of Xi an Jiaotong University School of Medicine, Xi an 710061, China
    J Clin Endocrinol Metab 99:E1163-72. 2014
    ..However, until now, its biological role in thyroid cancer remains totally unknown...
  74. doi Methylation of CTNNA1 promoter: frequent but not an adverse prognostic factor in acute myeloid leukemia
    Xing xing Chen
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, 8 Dianli Rd, 212002 Zhenjiang, Jiangsu, People s Republic of China
    Leuk Res 38:613-8. 2014
    ..681). Our data suggest that CTNNA1 methylation is a recurrent event but has no influence on prognosis in AML. ..
  75. doi Elevation of PRKCDBP, a novel transcriptional target of tnf-α, and its downregulation by infliximab in patients with ulcerative colitis
    Jung Wook Kim
    Division of Gastroenterology, Department of Internal Medicine, Kyung Hee University School of Medicine, 23 Kyungheedae ro, Dongdaemun Gu, Seoul, 130 872, Republic of Korea
    Dig Dis Sci 59:2947-57. 2014
    ..Recently, PRKCDBP was identified to be activated by nuclear factor-κB in response to tumor necrosis factor (TNF)-α...
  76. pmc Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS
    Rebekka K Schneider
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 26:509-20. 2014
    ..These studies demonstrate that CSNK1A1 plays a central role in the biology of del(5q) MDS and is a promising therapeutic target. ..
  77. pmc Cloning and expression analysis of prohibitin mRNA in canine mammary tumors
    Satoshi Matsuyama
    Laboratory of Veterinary Radiology, Division of Veterinary Sciences, Osaka Prefecture University, 1 58 Rinku Ohraikita, Izumisano Osaka 598 8531, Japan
    J Vet Med Sci 77:101-4. 2015
    ..Canine prohibitin mRNA was expressed in all normal mammary and tumor samples examined. These results suggest that this protein plays a vital role in cell growth mechanisms and may be related to the occurrence of canine mammary tumors. ..
  78. doi Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas
    A G Kondratov
    Department of Molecular Oncogenetics, Institute of Molecular Biology and Genetics, 03143 Kiev, Ukraine
    Mol Med Rep 5:509-12. 2012
    ..We found that the LRRC3B gene promoter was methylated in 43% of clear cell renal carcinoma samples. However, no correlation between DNA methylation and LRRC3B expression was found...
  79. doi Transforming growth factor-β-stimulated clone-22 is a negative-feedback regulator of Ras / Raf signaling: Implications for tumorigenesis
    Masaki Nakamura
    Division of Cellular Therapy, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Cancer Sci 103:26-33. 2012
    ..Thus, TSC-22 negatively regulated Ras/Raf signaling through a mechanism different from GILZ, implicating TSC-22 as a novel suppressor of oncogenic Ras/Raf-induced tumors...
  80. pmc TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma
    Shumin Wang
    Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, PR China
    BMC Cancer 10:617. 2010
    ..Recently, TFPI-2 was suggested to be a tumor suppressor gene involved in tumorigenesis and metastasis in some cancers. In this study, we investigated whether TFPI-2 was inactivated epigenetically in nasopharyngeal carcinoma (NPC)...
  81. pmc Quantitative detection of multiple gene promoter hypermethylation in tumor tissue, serum, and cerebrospinal fluid predicts prognosis of malignant gliomas
    Bo Lin Liu
    Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xijing Hospital, Fourth Military Medical University, West Changle Road, No 127, Xi an, Shaanxi Province 710032, People s Republic of China
    Neuro Oncol 12:540-8. 2010
    ..Evaluation of these changes may help in selecting glioma patients for optimal adjuvant treatments and modifying chemotherapy...
  82. ncbi Localization of the gene encoding a type I protein phosphatase catalytic subunit to human chromosome band 11q13
    H M Barker
    Department of Biochemistry, University of Dundee, Scotland
    Genomics 7:159-66. 1990
    ..Neoplasms that map to 11q13 are discussed in the light of the recent findings that PP1 alpha is a putative tumor suppressor and that it plays a key role in the control of mitosis...
  83. doi The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma
    P N Kongkham
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Toronto, Ontario, Canada M5G 1X8
    Oncogene 29:3017-24. 2010
    ....
  84. ncbi Pseudogene INTS6P1 regulates its cognate gene INTS6 through competitive binding of miR-17-5p in hepatocellular carcinoma
    Haoran Peng
    Division of Gastroenterology and Hepatology, Department of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    Oncotarget 6:5666-77. 2015
    ..Our investigation of this regulatory circuit reveals novel insights into the underlying mechanisms of hepatocarcinogenesis. ..
  85. doi Clonal heterogeneity in childhood myelodysplastic syndromes--challenge for the detection of chromosomal imbalances by array-CGH
    Inka Praulich
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Genes Chromosomes Cancer 49:885-900. 2010
    ..Our results clearly emphasize the need to verify array-CGH results by independent methods like FISH or quantitative PCR...
  86. pmc Epigenetic inactivation of the NORE1 gene correlates with malignant progression of colorectal tumors
    Chang Kyun Lee
    Division of Gastroenterology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea
    BMC Cancer 10:577. 2010
    ..However, expression and mutation status of NORE1 and its implication in colorectal tumorigenesis has not been evaluated...
  87. pmc Parathyroid cancer
    John M Sharretts
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1752, USA
    Semin Oncol 37:580-90. 2010
    ..Metastatic disease can be palliated with surgical debulking. Medical therapy with the calcimimetic cinacalcet and bisphosphonates can ameliorate hypercalcemia in patients with inoperable disease...
  88. pmc Use of integrative epigenetic and cytogenetic analyses to identify novel tumor-suppressor genes in malignant melanoma
    Suhail K Mithani
    Department of Plastic and Reconstructive Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Melanoma Res 21:298-307. 2011
    ..All of these genes demonstrated growth-suppressive properties with transfection into melanoma-derived cell lines. Seven putative tumor-suppressor genes in malignant melanoma were identified using a novel integrative technique...
  89. doi Physical activity and breast cancer survival: an epigenetic link through reduced methylation of a tumor suppressor gene L3MBTL1
    Hongmei Zeng
    Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Public Health, 60 College Street, PO Box 208034, New Haven, CT 06520 8034, USA
    Breast Cancer Res Treat 133:127-35. 2012
    ..In conclusion, the study suggests that increasing physical activity after a breast cancer diagnosis may affect epigenetic regulation of tumor suppressor genes, which have favorable impacts on survival outcomes of breast cancer patients...
  90. doi The promoter hypermethylation status of GATA6, MGMT, and FHIT in glioblastoma
    Gulsah Cecener
    Department of Medical Biology, School of Medicine, Uludag University, Bursa, Turkey
    Cell Mol Neurobiol 32:237-44. 2012
    ..Furthermore, inactivation of FHIT by epigenetic mechanisms in GBM may not be associated with brain tumorigenesis...
  91. pmc IER3 is a crucial mediator of TAp73β-induced apoptosis in cervical cancer and confers etoposide sensitivity
    Hanyong Jin
    Department of Pharmacy, CHA University, Seongnam, 463 836, Korea
    Sci Rep 5:8367. 2015
    ..Therefore, TAp73β and IER3 induction would be a valuable checkpoint for successful therapeutic intervention of cervical carcinoma patients. ..
  92. ncbi Hypermethylation of HIC-1 and 17p allelic loss in medulloblastoma
    Brian R Rood
    Department of Pediatric Hematology Oncology, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Cancer Res 62:3794-7. 2002
    ..014). The results of our study show that methylation of the CpG island that contains the HIC-1 gene is common in medulloblastoma and, together with LOH of 17p, may be a critical event in the formation and aggressiveness of this tumor...
  93. ncbi Analysis of the transcription regulator, CNOT7, as a candidate chromosome 8 tumor suppressor gene in colorectal cancer
    James Flanagan
    The Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Queensland, Australia
    Int J Cancer 106:505-9. 2003
    ..The rarity of somatic mutations in CNOT7, and its expression in primary colorectal tumors and cell lines, suggests that CNOT7 is not the target tumor suppressor gene in the 8p22-23.1 CRCSR...
  94. ncbi Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms
    Izumi Horikawa
    Laboratory of Biosystems and Cancer, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 37, Room 5046, MSC 4264, Bethesda, MD 20892, USA
    Carcinogenesis 24:1167-76. 2003
    ....
  95. ncbi Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers
    Ajay Goel
    Department of Medicine and Comprehensive Cancer Center, University of California San Diego, La Jolla, CA, USA
    Int J Cancer 112:754-9. 2004
    ..The significant association of RUNX3 promoter hypermethylation with MSI-H colon cancers suggests that RUNX3 is a novel target of methylation, along with the hMLH1 gene, in the evolution of MSI-H colorectal cancers...
  96. ncbi [Loss of heterozygosity on chromosome 9p13-23 in microdissected laryngeal squamous cell carcinoma by microsatellite analysis]
    X Xu
    Department of Otorhinolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
    Zhonghua Er Bi Yan Hou Ke Za Zhi 36:367-71. 2001
    ..To refine the hot spots of LOH on chromosome 9p13-23 will be helpful to find other putative tumor suppressor genes in laryngeal squamous cell carcinoma...
  97. ncbi Analysis of HIC-1 methylation and transcription in human ependymomas
    Anke Waha
    Department of Neuropathology, University of Bonn, Bonn, Germany
    Int J Cancer 110:542-9. 2004
    ..Of 27 ependymomas, 22 (81%) showed absent or low expression of HIC-1. The elevated methylation of HIC-1 in nonspinal ependymomas supports the hypothesis that spinal and nonspinal ependymomas represent genetically distinct entities...
  98. ncbi The prognostic value of p27 in gastric cancer
    Jan Patrik Wiksten
    Department of Surgery, University of Helsinki, Helsinki, Finland
    Oncology 63:180-4. 2002
    ..Results in gastric cancer are contradictory. We therefore decided to study the potential of p27 as a prognostic marker in a consecutively surgically treated, single-institution series of patients...
  99. ncbi Delineation and candidate gene mutation screening of the 18q22 minimal region of deletion in head and neck squamous cell carcinoma
    Hélène Blons
    Unite de Toxicologie Moléculaire, U490 INSERM, 45 Rue des Saints Pères 75006 Paris, France
    Oncogene 21:5016-23. 2002
    ..However, differential transcription levels were observed for CDH19 and Hs.96900 in head and neck cancer cell lines supporting their putative involvement through down regulation mechanisms in head and neck cancer progression...
  100. ncbi Activin type II receptor restoration in ACVR2-deficient colon cancer cells induces transforming growth factor-beta response pathway genes
    Elena Deacu
    Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Res 64:7690-6. 2004
    ....
  101. ncbi Adrenocortical cells are the site of secretion and action of insulin-like growth factors and TNF-alpha
    R Voutilainen
    Department of Pediatrics, Kuopio University Hospital, Finland
    Horm Metab Res 30:432-5. 1998
    ..It is produced in adrenocortical steroidogenic cells in addition to macrophages, which suggests that tumor necrosis factor-alpha may have some autocrine/paracrine functions in the adrenal cortex...

Research Grants62

  1. IL-15 Characterization Through Experimental Immunology
    Michael A Caligiuri; Fiscal Year: 2013
    ..Funding of this proposal will advance our understanding of basic immunology as well as strategies to prevent and treat cancer. ..
  2. MOLECULAR PROGRESSION MODEL FOR HNSCC
    David Sidransky; Fiscal Year: 2012
    ..These early molecular events will be identified and developed as targets for early detection and staging approaches, with emphasis on molecular detection strategies amenable to rapid, automated application. ..
  3. TUMOR SUPPRESSOR GENES IN HUMAN THYROID NEOPLASMS
    James Fagin; Fiscal Year: 1990
    ....
  4. ISOLATION OF TUMOR SUPPRESSOR GENES IN RHABDOMYOSARCOMA
    Mary Sugrue; Fiscal Year: 2000
    ..Selection of RD transfectants based on induction of a growth- inhibited or differentiated phenotype will be attempted. 3) Molecular characterization of putative tumor suppressor gene(s). ..
  5. ALLELE LOSS IN THE GENESIS OF GASTRIC CANCER
    Barbara Schneider; Fiscal Year: 1999
    ..Since these proteins are likely to participate critically in reducing cell proliferation the study of each of them holds the potential to reveal more specific therapies for cancer. ..
  6. Characterization of Human 3p Recessive Oncogenes
    John Minna; Fiscal Year: 2004
    ..mutation, suppression of the malignant phenotype) including CACNA2D2, 101F6, NPR21/G21, BLU, FUSI, HYAL1, and FUS2. The current proposal will: Confirm the tumor suppressing function of RASSF1A and SEMA3B and further implicate or ..
  7. Detection of Novel Gene Defects in Basal Cell Carcinoma
    Steven Fakharzadeh; Fiscal Year: 2005
    ..abstract_text> ..
  8. Use of RNAi to investigate cullin-5 function in breast cancer
    Michael Fay; Fiscal Year: 2006
    ..A better understanding of cancer-related genes, such as Cul5, is expected to lead to better therapies for patients. [unreadable] [unreadable] [unreadable] [unreadable]..
  9. STATISTICAL METHODS FOR MOLECULAR CANCER DATA
    Michael Newton; Fiscal Year: 1999
    ..Computer simulation of the model will be useful both to study bias and variance properties of the proposed methods and as the basis for power calculations to design marker studies. ..
  10. CLONING A GENE AT 12Q22 DELETION IN GERM CELL TUMORS
    Murty Vundavalli; Fiscal Year: 2001
    ..Subsequently, the TSG will be characterized as to its evolutionalry conservation, genomic organization, normal function, and specific role in tumorigenesis. ..
  11. SIGNIFICANCE OF ALLELIC DELETIONS IN NEUROBLASTOMA
    John Maris; Fiscal Year: 1999
    ..These studies should also substantially contribute towards the positional cloning of three neuroblastoma suppressor genes and our basic understanding of the molecular genetics of this common pediatric tumor. ..
  12. SIGNALING MECHANISM IN DCC-INDUCED APOPTOSIS
    Yong Chen; Fiscal Year: 2003
    ....
  13. Role of POZ-zinc finger proteins in tumorigenesis.
    Pier Paolo Pandolfi; Fiscal Year: 2013
    ..In view of the critical role exerted by this protein in tumorigenesis and embryonic development the further elucidation of POKEMON/LRF function and role in human cancer is of great relevance to biomedical research. ..
  14. Regulation of Pancreatic Tumor Progression by Disabled-2
    Barbara A Hocevar; Fiscal Year: 2010
    ..The studies proposed here will provide prelimary evidence to support a role of Disabled-2 in prevention of pancreatic tumor progression and metastasis which may lead to improved diagnosis and treatment of pancreatic cancer. ..
  15. Colorectal Cancer Prevention Through Thyroid Hormone Targets
    ADAM ROBERT BROWN; Fiscal Year: 2013
    ..The successful completion of the study will provide insight into potential age-dependent targets that may lead to the development of new therapies to prevent or treat age-related colorectal cancer. ..
  16. Investigation of Notch-inhibiting microRNAs in glioma
    Benjamin W Purow; Fiscal Year: 2013
    ..In this proposal, we will investigate two microRNAs as tumor suppressors and therapies in glioma secondary to their inhibition of the Notch pathway, a central pathway in stem cells, cell fate, and cancer. ..
  17. A new regulator for Wnt/beta-catenin signaling and prostate tumorigenesis
    Zijie Sun; Fiscal Year: 2013
    ..Insights into new diagnostic markers, therapeutic targets and approaches for prostate cancer and other tumors are expected. ..
  18. Role of the Putative Tumor Suppressor PinX1 in the Etiology of Liver Cancer
    Xiao Zhen Zhou; Fiscal Year: 2010
    ..These studies would establish new animal models for studying liver cancer and provide novel insight into the etiology and treatment of liver cancer. ..
  19. Role of TET2 in normal hematopoiesis and pathogenesis of myeloid malignancies
    Mingjiang Xu; Fiscal Year: 2013
    ..The Tet2 murine models also offer a biological context in which drugs and other therapies can be tested and developed. ..
  20. Semaphorin 3F: Structure, Function, and Anti-Metastatic Activity
    Diane Renee Bielenberg; Fiscal Year: 2010
    ..Most of all, a Howard Temin Award would enable the continuation of this research project toward the ultimate goal of long-term stable disease. ..
  21. Role of NIAM, A Putative Cancer Gene, in Chromosomal Instability and Glioblastoma
    SARA MARIE FRANCIS-REED; Fiscal Year: 2013
    ..My ultimate goal is to become an independent physician scientist studying pediatric cancers. I am excited that this training experience will effectively prepare me for such a career in translational cancer research. ..
  22. LCM Analysis and Mouse Models to Validate miRs in Prostate Tumor Progression
    ZENDRA ELIZABETH ZEHNER; Fiscal Year: 2012
    ....
  23. KLF4 Genetic and Epigenetic Changes in Human Pancreatic Cancer
    Keping Xie; Fiscal Year: 2012
    ..However, the critical role of KLF4 signaling in human cancer development and progression in general and human pancreatic cancer in particular is unclear. ..
  24. CORRELATIVE STUDIES USING SPECIMENS FROM SWOG 9321
    John Shaughnessy; Fiscal Year: 2000
    ..Specific Aim 3: Evaluate whether chromosome 13 deletions correlate with clinical outcome (complete remission, event free survival, and overall survival). ..
  25. CLONING NOVEL GENES FOR PAGETS DISEASE AND OSTEOSARCOMA
    Marc Hansen; Fiscal Year: 2001
    ....
  26. MECHANISMS OF ENZYMATIC REACTIONS
    PERRY FREY; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  27. BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    Joseph Wiemels; Fiscal Year: 2006
    ..We are ultimately working to elucidate the origin and causes of a cancer that might be preventable. [unreadable] [unreadable]..
  28. DNA METHYLATION AND SOD2/MNSOD GENE EXPRESSION
    Frederick Domann; Fiscal Year: 2002
    ..A better understanding of the mechanisms of regulation of the expressio of SOD2 during carcinogenesis and differentiation may lead to new strategies for the treatment of diseases in which aberrant SOD2 expression plays a key role. ..
  29. SUPPRESSION OF TUMOR PROGRESSION BY CONNEXIN 43
    Shu Chih Chen; Fiscal Year: 2000
    ....
  30. Characterization of HIN1 Putative Tumor Suppressor
    Ian Krop; Fiscal Year: 2003
    ..The results of these studies will thus determine the role of HIN-1 as a potential tumor suppressor gene and, since it is inactivated frequently in early BC, may provide an excellent target for preventive intervention. ..
  31. MOLECULAR ANALYSIS OF THE DEL(20Q) IN MYELOID LEUKEMIAS
    MICHELLE LE BEAU; Fiscal Year: 2003
    ..abstract_text> ..
  32. METABOLISM AND TOXICITY OF HYDROQUINONE-THIOETHERS
    Serrine Lau; Fiscal Year: 2003
    ..The overall goals of this aim are to characterize the Eker animal model in which the effects of environmental influences (chemical exposure) on a genetic predisposition to cancer are determined. ..
  33. Identification of Receptor for Tumor Suppressor HIN-1
    Dale Porter; Fiscal Year: 2003
    ..abstract_text> ..
  34. Function and Regulation of Pin2/TRF1 and PinX1
    Kun Ping Lu; Fiscal Year: 2005
    ..These studies should yield new insights into telomere maintenance, cell growth control and oncogenesis, and may lead to the development of new anticancer therapy. ..
  35. MAPPING GENETIC SUPPRESSORS OF EPIGENETIC CARCINOGENESIS
    Helmut Zarbl; Fiscal Year: 2002
    ....
  36. PinX1, a Putative Tumor Suppressor for Prostate Cancer
    Xiao Zhou; Fiscal Year: 2004
    ..Furthermore, these pilot studies are novel and will serve as the first step in obtaining R01 support from NIH to start a new project on prostate cancer. ..
  37. DNA methylation patterns as biomarker for breast cancer
    Kristin Skinner; Fiscal Year: 2003
    ..These future studies will determine whether DNA methylation changes can be used a) to stratify women at risk for breast cancer and b) as a surrogate endpoint in chemoprevention trials. ..
  38. CELL CYCLE REGULATORS OF ORAL CANCER
    JAMES RHEINWALD; Fiscal Year: 2002
    ..These Cores will also validate conclusions from the research projects in human oral cancer tissues. ..
  39. DNA polymerase iota as a putative tumor suppressor
    William G McGregor; Fiscal Year: 2010
    ..The ultimate goal of this research is to understand how carcinogens cause cancer in order to design strategies to prevent the disease. ..
  40. BRCA1 AND DIFFERENTIATION AND ENDOCRINE RISK FACTOR
    Lewis Chodosh; Fiscal Year: 2000
    ..Ultimately, understanding the role played by BRCA1 in the regulation of these processes has the potential to lead to novel strategies for the prevention and treatment of breast cancer. ..
  41. Regulation of Bcl2 Function Via Ceramide-Activated PP2A
    Peter Ruvolo; Fiscal Year: 2006
    ..From these results, it is expected that the development of novel anticancer strategies that target mechanisms regulating Bc12 function will occur...
  42. Genetic Modifiers of p53
    Susan Evans; Fiscal Year: 2005
    ..abstract_text> ..
  43. EXPRESSION AND FUNCTION OF CUL 5/VACM 1 IN BREAST CANCER
    Michael Fay; Fiscal Year: 2000
    ..abstract_text> ..
  44. CHROMOSOME 9P ABERRATIONS IN GLIOMA
    Dennis Carson; Fiscal Year: 1999
    ....
  45. DOC-1R, A NOBEL CDK2-ASSOCIATED PROTEIN
    Xue Zhang; Fiscal Year: 2000
    ..The long term goal of this proposal is to substantiate the role of DOC-1R as a new CDK2 regulatory protein, in the regulation of CDK2-mediated cell cycle biology in normal and tumor development. ..
  46. LYSYL OXIDASE GENE MUTATIONS IN COLON CANCER
    Katalin Csiszar; Fiscal Year: 2001
    ..This proposal seeks to characterize these 5q23 rearrange- ments in order to begin to understand the role of lysyl oxidase gene mutations in the cascade of genetic events that lead to colorectal tumorigenesis. ..
  47. APC2 AND BREAST CANCER
    Stephen Byers; Fiscal Year: 2002
    ..Targets of beta-catenin signaling include cyclin Dl and c-myc, both of which are commonly overexpressed in human breast cancers. We will relate the cytogenetics of APC2 to the expression of cyclin D1 and c-myc breast cancers. ..
  48. Influence of ErbB4 activity on metastatic breast cancer
    Frank Jones; Fiscal Year: 2007
    ..abstract_text> ..
  49. BRCA2 FUNCTION IN MAMMARY EPITHELIAL BIOLOGY
    Lewis Chodosh; Fiscal Year: 2002
    ..We will also determine whether Brca2 is posttranslationally modified following DNA damage in a manner similar to that observed for Brca1. Finally, we will determine whether Brca2 and Brca1 interact during these processes. ..
  50. P27Kipl deficiency, potential promoter of carcinogenesis
    Konstantin Christov Tzelkov; Fiscal Year: 2003
    ..abstract_text> ..
  51. TOPOISOMERASES IN RETINOID INDUCED DIFFERENTIATION
    Andrew Yen; Fiscal Year: 2003
    ..Andrew Yen, who brings expertise on the molecular and cellular biology of retinoic acid-induced myeloid differentiation. ..
  52. Conference Proposal: Calcium and Cell Function
    Craig Montell; Fiscal Year: 2004
    ..The topics to be covered at the meeting are of fundamental importance and are relevant to understanding the bases of a diseases such as neurodegeneration, communicative disorders, aging, cancer, kidney and cardiovascular disease. ..
  53. Biomarker modulation/COX-2 inhibitor/Breast Cancer
    Banu Arun; Fiscal Year: 2003
    ..Ultimately, the development of non-hormonal chemoprevention agents, and identification of surrogate markers will allow us to plan large-scale, phase III chemoprevention studies with the endpoint of cancer incidence. ..
  54. HUNK AND PUNC FUNCTION IN MAMMARY EPITHELIAL BIOLOGY
    Lewis Chodosh; Fiscal Year: 2004
    ....
  55. FLUORESCENCE ACTIVATED CELL SORTER
    Andrew Yen; Fiscal Year: 2004
    ..The instrument requested is a Dako-Cytomation basic MoFlo plus a UV-vis, vis, and HeNe laser to provide independent UV, vis/488, and red excitation. ..
  56. PARADIGM OF MULTISTEP URINARY BLADDER CARCINOGENESIS
    Bogdan Czerniak; Fiscal Year: 2006
    ....
  57. Mechanisms of Progression in c-MYC-Induced Breast Cancer
    Lewis Chodosh; Fiscal Year: 2006
    ..abstract_text> ..
  58. Retinoic Acid Regulated Cell Differentiation: BLR1 Rcptr
    Andrew Yen; Fiscal Year: 2005
    ..It has the implication that the ultimate effects of RA can be governed by relevant growth factors signaling through their cognate receptors. ..
  59. ROLE OF FRAGILE SITES IN CHROMOSOME BREAKAGE AND CANCER
    Thomas Glover; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  60. FOXC2 in Hereditary Lymphedema and Lymphatic Development
    Thomas Glover; Fiscal Year: 2007
    ..abstract_text> ..
  61. Role of Oxidants & Angiogenesis in Kaposi's Sarcoma
    Susan Mallery; Fiscal Year: 2007
    ..Elucidation of these interactions will not only clarify KS pathogenic mechanisms, but will also identify sites for KS therapeutic intervention. ..