NAT6

Summary

Gene Symbol: NAT6
Description: N-acetyltransferase 6 (GCN5-related)
Alias: FUS-2, FUS2, N-acetyltransferase 6, protein fusion-2
Species: human

Top Publications

  1. ncbi The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium
    M I Lerman
    Laboratory of Immanobiology, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA
    Cancer Res 60:6116-33. 2000
  2. ncbi Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas
    Paulisally Hau Yi Lo
    Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, People s Republic of China
    Cancer Lett 234:184-92. 2006
  3. ncbi Familial partial monosomy 7 and myelodysplasia: different parental origin of the monosomy 7 suggests action of a mutator gene
    A Minelli
    Biologia Generale e Genetica Medica, , C.P. 217, I 27100, Pavia, Italy
    Cancer Genet Cytogenet 124:147-51. 2001
  4. ncbi [Detailed mapping and clinical significance of loss of heterozygosity on 9p13-23 in laryngeal squamous cell carcinoma by microsatellite analysis]
    Xian fa Xu
    Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing, PR China
    Ai Zheng 22:452-7. 2003
  5. ncbi Transcriptional repression mediated by the WT1 Wilms tumor gene product
    S L Madden
    Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104
    Science 253:1550-3. 1991
  6. ncbi Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein
    Hansoo Lee
    Department of Pathology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    Mol Cell Biol 27:2103-19. 2007
  7. ncbi beta-carotene-induced changes in RARbeta isoform mRNA expression patterns do not influence lung adenoma multiplicity in the NNK-initiated A/J mouse model
    Regina Goralczyk
    DSM Nutritional Products Ltd, Research and Development, Human Nutrition and Health, Basel, Switzerland
    Nutr Cancer 54:252-62. 2006
  8. ncbi Allelotyping in mycosis fungoides and Sézary syndrome: common regions of allelic loss identified on 9p, 10q, and 17p
    J J Scarisbrick
    Skin Tumour Unit, St John s Institute Dermatology, St Thomas Hospital, London, UK
    J Invest Dermatol 117:663-70. 2001
  9. ncbi ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways
    Michele A Battle
    Carcinogenesis Laboratory, Cell and Molecular Biology Program, Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 1302, USA
    Biochemistry 42:7270-82. 2003
  10. ncbi Screening and identification of down-regulated genes in colorectal carcinoma by subtractive hybridization: a method to identify putative tumor suppressor genes
    S Zheng
    Cancer Institute, Zhejiang Medical University, Hangzhou, China
    Chin Med J (Engl) 110:543-7. 1997

Research Grants

  1. Characterization of Human 3p Recessive Oncogenes
    John Minna; Fiscal Year: 2004
  2. 17Q25 BREAST CANCER GENE--ISOLATION AND ANALYSIS
    ELIZABETH PETTY; Fiscal Year: 1999
  3. Use of RNAi to investigate cullin-5 function in breast cancer
    Michael Fay; Fiscal Year: 2006
  4. Detection of Novel Gene Defects in Basal Cell Carcinoma
    Steven Fakharzadeh; Fiscal Year: 2005
  5. SIGNALING MECHANISM IN DCC-INDUCED APOPTOSIS
    Yong Chen; Fiscal Year: 2003
  6. DNA methylation patterns as biomarker for breast cancer
    Kristin Skinner; Fiscal Year: 2003
  7. MECHANISMS OF ENZYMATIC REACTIONS
    PERRY FREY; Fiscal Year: 2002
  8. CLONING NOVEL GENES FOR PAGETS DISEASE AND OSTEOSARCOMA
    Marc Hansen; Fiscal Year: 2001
  9. Role of POZ-zinc finger proteins in tumorigenesis.
    Pier Paolo Pandolfi; Fiscal Year: 2011
  10. Role of POZ-zinc finger proteins in tumorigenesis.
    Pier Paolo Pandolfi; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications121 found, 100 shown here

  1. ncbi The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium
    M I Lerman
    Laboratory of Immanobiology, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA
    Cancer Res 60:6116-33. 2000
    ..of the genes to have two or more amino acid sequence-altering mutations including BLU, NPRL2/Gene21, FUS1, HYAL1, FUS2, and SEMA3B...
  2. ncbi Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas
    Paulisally Hau Yi Lo
    Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, People s Republic of China
    Cancer Lett 234:184-92. 2006
    The expression of six chromosome 3p21.3 candidate tumor suppressor genes (BLU, FUS2, HYAL2, NPRL2, RASSF1A, and SEMA3B) in esophageal squamous cell carcinoma (ESCC) has been investigated...
  3. ncbi Familial partial monosomy 7 and myelodysplasia: different parental origin of the monosomy 7 suggests action of a mutator gene
    A Minelli
    Biologia Generale e Genetica Medica, , C.P. 217, I 27100, Pavia, Italy
    Cancer Genet Cytogenet 124:147-51. 2001
    ..We postulate that, in fact, an inherited mutation in any of a group of mutator genes causes familial monosomy 7 also in the absence of a recognized mendelian disease, and that marrow chromosome 7 anomalies, in turn, lead to MDS/AML...
  4. ncbi [Detailed mapping and clinical significance of loss of heterozygosity on 9p13-23 in laryngeal squamous cell carcinoma by microsatellite analysis]
    Xian fa Xu
    Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing, PR China
    Ai Zheng 22:452-7. 2003
    ..This study was designed to refine the hot spots of LOH on 9p13-23 in laryngeal squamous cell carcinoma and compare the correlation between the incidence of microsatellite LOH and the clinicopathological parameters...
  5. ncbi Transcriptional repression mediated by the WT1 Wilms tumor gene product
    S L Madden
    Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104
    Science 253:1550-3. 1991
    ..The repression function was mapped to the glutamine- and proline-rich NH2-terminus of WT1; fusion of this domain to the zinc finger region of EGR-1 converted EGR-1 into a transcriptional repressor...
  6. ncbi Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein
    Hansoo Lee
    Department of Pathology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    Mol Cell Biol 27:2103-19. 2007
    ..Collectively, these findings indicate that NGB is a tumor suppressor that regulates and requires merlin to suppress cell proliferation...
  7. ncbi beta-carotene-induced changes in RARbeta isoform mRNA expression patterns do not influence lung adenoma multiplicity in the NNK-initiated A/J mouse model
    Regina Goralczyk
    DSM Nutritional Products Ltd, Research and Development, Human Nutrition and Health, Basel, Switzerland
    Nutr Cancer 54:252-62. 2006
    ..Down-regulation of RARbeta in NNK-induced adenoma-bearing lungs was similar to that observed in human lung cancer and further confirms the A/J-mouse as a valuable model for lung carcinogenesis...
  8. ncbi Allelotyping in mycosis fungoides and Sézary syndrome: common regions of allelic loss identified on 9p, 10q, and 17p
    J J Scarisbrick
    Skin Tumour Unit, St John s Institute Dermatology, St Thomas Hospital, London, UK
    J Invest Dermatol 117:663-70. 2001
    ..These results provide the basis for further studies defining more accurately chromosomal regions of deletions and candidate tumor suppressor genes involved in mycosis fungoides and Sézary syndrome...
  9. ncbi ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways
    Michele A Battle
    Carcinogenesis Laboratory, Cell and Molecular Biology Program, Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 1302, USA
    Biochemistry 42:7270-82. 2003
    ..Clearly, ST7 is an LRP, and therefore, it should now be referred to as LRP12...
  10. ncbi Screening and identification of down-regulated genes in colorectal carcinoma by subtractive hybridization: a method to identify putative tumor suppressor genes
    S Zheng
    Cancer Institute, Zhejiang Medical University, Hangzhou, China
    Chin Med J (Engl) 110:543-7. 1997
    ..To search for new putative tumor suppressor genes in colorectal carcinoma...
  11. ncbi Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis
    Timothy A Chan
    Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America
    PLoS Med 5:e114. 2008
    ..We hypothesize that key tumor suppressor genes in cancer may be subject to mutation or hypermethylation...
  12. ncbi mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells
    Li Hui
    Department of Biological Sciences, Hunter College of the City University of New York, New York, New York 10021, USA
    J Biol Chem 280:35829-35. 2005
    ..The ability of phospholipase D to suppress protein phosphatase 2A identifies a critical target of an emerging phospholipase D/mTOR survival pathway in the transformation of human cells...
  13. ncbi Fus2 localizes near the site of cell fusion and is required for both cell fusion and nuclear alignment during zygote formation
    E A Elion
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    J Cell Biol 130:1283-96. 1995
    ..Genetic evidence suggests that the FUS2 gene product promotes cell fusion during zygote formation in Saccharomyces cerevisiae, functioning with the Fus1 ..
  14. ncbi Merlin knockdown in human Schwann cells: clues to vestibular schwannoma tumorigenesis
    Zana Ahmad
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of California San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, U S A
    Otol Neurotol 31:460-6. 2010
    ..To investigate the early events in molecular progression toward schwannoma tumorigenesis, we developed an in vitro model of human Schwann cell tumorigenesis by merlin knockdown...
  15. ncbi A retinoic acid receptor beta/gamma-selective prodrug (tazarotene) plus a retinoid X receptor ligand induces extracellular signal-regulated kinase activation, retinoblastoma hypophosphorylation, G0 arrest, and cell differentiation
    Andrew Yen
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Mol Pharmacol 66:1727-37. 2004
    ..Tazarotene used with RXR-selective ligand may thus be a useful antineoplastic agent in differentiation induction therapy as exemplified by the prototypical RA treatment of acute promyelocytic leukemia...
  16. ncbi Osmotic balance regulates cell fusion during mating in Saccharomyces cerevisiae
    J Philips
    Department of Biochemistry and Biophysics, Programs in Genetics and Cell Biology, San Francisco, California 94143 0448, USA
    J Cell Biol 138:961-74. 1997
    ..fusion is regulated, we identified mutants defective in cell fusion based upon their defect in mating to a fus1 fus2 strain (Chenevert, J., N. Valtz, and I. Herskowitz. 1994. Genetics 136:1287-1297)...
  17. ncbi Frequent loss of heterozygosity at the 19p13.3 locus without LKB1/STK11 mutations in human carcinoma metastases to the brain
    S B Sobottka
    Department of Neurosurgery, Technical University of Dresden, Germany
    J Neurooncol 49:187-95. 2000
    ..Based on these findings, the genes adjacent to LKB1/STK11 may be relevant for the development of metastases to the brain from certain carcinomas...
  18. ncbi Frequent occurrence of Ha-rasl allelic deletion in human ovarian adenocarcinomas
    A Viel
    Division of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano, Pordenone, Italy
    Tumori 77:16-20. 1991
    ..These findings may suggest that a putative tumor suppressor gene closely linked to Ha-rasl in 11p15.5 is involved in ovarian cancerogenesis...
  19. ncbi Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas
    Javier Silva
    Department of Medical Oncology, Hospital Universitario Puerta de Hierro, c San Martin de Porres, E 28035 Madrid, Spain
    Mutat Res 594:78-85. 2006
    ..Future and larger series studies in different tumor types are necessary to clarify Ris-1 function in human cancer...
  20. ncbi Down-regulation of SFRP1 as a putative tumor suppressor gene can contribute to human hepatocellular carcinoma
    Jian Huang
    Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China
    BMC Cancer 7:126. 2007
    ..However, whether the down-regulation of SFRP1 can contribute to hepatocarcinogenesis still remains unclear...
  21. ncbi Diminished levels of the putative tumor suppressor proteins EXT1 and EXT2 in exostosis chondrocytes
    M A Bernard
    Department of Pediatrics, University of Texas Houston Medical School, Houston, Texas 77225 0708, USA
    Cell Motil Cytoskeleton 48:149-62. 2001
    ..These results suggest that multiple mutational steps are involved in exostosis development and that EXT genes play a role in cell signaling related to chondrocyte cytoskeleton regulation...
  22. ncbi Clonal heterogeneity in childhood myelodysplastic syndromes--challenge for the detection of chromosomal imbalances by array-CGH
    Inka Praulich
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Genes Chromosomes Cancer 49:885-900. 2010
    ..Our results clearly emphasize the need to verify array-CGH results by independent methods like FISH or quantitative PCR...
  23. ncbi Slow endocytosis of the LDL receptor-related protein 1B: implications for a novel cytoplasmic tail conformation
    Jane M Knisely
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Cell Res 313:3298-307. 2007
    ..From these data, we propose that both halves of the LRP1B cytoplasmic tail contribute to a unique global conformation, which results in less efficient recognition by endocytic adaptors and a slow endocytosis rate...
  24. ncbi Inhibition of growth by p205: a nuclear protein and putative tumor suppressor expressed during myeloid cell differentiation
    Jonathan M Dermott
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702 1201, USA
    Stem Cells 22:832-48. 2004
    ..We propose that during myelomonocytic cell differentiation, induction of p205 expression contributes to cell growth arrest, thus allowing progenitor cells to differentiate...
  25. ncbi Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration
    Yonghe Li
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, Missouri 63110, USA
    J Biol Chem 277:42366-71. 2002
    ..Taken together, these results demonstrate that LRP1B can function as a negative regulator of uPAR regeneration and cell migration...
  26. ncbi The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production
    Judy A Cam
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:29639-46. 2004
    ..These findings reveal that LRP1B is a novel binding partner of APP that functions to decrease APP processing to Abeta. Consequently LRP1B expression could function to protect against the pathogenesis of Alzheimer's disease...
  27. ncbi Loss of heterozygosity on chromosome 22q in gastrointestinal stromal tumors (GISTs): a study on 50 cases
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Lab Invest 85:237-47. 2005
    ..An isolated LOH at D22S425 was equally found in both benign and malignant tumors. These observations may suggest that LOHs on chromosome 22q in GISTs play a role in early stages of tumor formation as well as in late tumor progression...
  28. ncbi Microdissecting the genetic events in nephrogenic rests and Wilms' tumor development
    A K Charles
    Department of Pediatric Pathology, St Michael s Hospital, Bristol, United Kingdom
    Am J Pathol 153:991-1000. 1998
    ..Intralobar and perilobar nephrogenic rests are known to have different biological behaviors, and this study suggests that they are genetically different. A multistep model of Wilms' tumor pathogenesis is supported by these findings...
  29. ncbi Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer
    Ruben Agrelo
    Cancer Epigenetics Laboratory, Spanish National Cancer Centre, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 103:8822-7. 2006
    ..These findings highlight the importance of WRN epigenetic inactivation in human cancer, leading to enhanced chromosomal instability and hypersensitivity to chemotherapeutic drugs...
  30. ncbi Non-linkage of familial rhabdoid tumors to SMARCB1 implies a second locus for the rhabdoid tumor predisposition syndrome
    Michael C Frühwald
    University Children s Hospital Muenster, Department of Paediatric Haematology and Oncology, Muenster, Germany
    Pediatr Blood Cancer 47:273-8. 2006
    ..2. Several familial cases have been published and summarized under the term rhabdoid tumor predisposition syndrome. In all of the published familial cases, inactivation of SMARCB1 was detected in tumor tissues...
  31. ncbi Quantitative detection of multiple gene promoter hypermethylation in tumor tissue, serum, and cerebrospinal fluid predicts prognosis of malignant gliomas
    Bo Lin Liu
    Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xijing Hospital, Fourth Military Medical University, West Changle Road, No 127, Xi an, Shaanxi Province 710032, People s Republic of China
    Neuro Oncol 12:540-8. 2010
    ..Evaluation of these changes may help in selecting glioma patients for optimal adjuvant treatments and modifying chemotherapy...
  32. ncbi Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice
    R H Zurawel
    Department of Neurological Surgery, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Genes Chromosomes Cancer 28:77-81. 2000
    ..Expression of Gli1 was increased in tumors compared to normal cerebellum. These results suggest that deletion of one copy of Ptch may be sufficient to promote medulloblastoma development in mice...
  33. ncbi Genetic analysis of childhood germ cell tumors with comparative genomic hybridization
    D T Schneider
    Clinic of Pediatric Hematology and Oncology, Heinrich Heine University, Medical Center, Dusseldorf, Germany
    Klin Padiatr 213:204-11. 2001
    ..As CGH does not require tissue culture, it also allows analysing archival tissue samples...
  34. ncbi Low expression of reduced folate carrier-1 and folylpolyglutamate synthase correlates with lack of a deleted in colorectal carcinoma mRNA splice variant in normal-appearing mucosa of colorectal carcinoma patients
    Yvonne Wettergren
    Department of General Surgery, Sahlgrenska University Hospital Ostra, Goteborg University, S 416 85 Goteborg, Sweden
    Cancer Detect Prev 29:348-55. 2005
    ..The purpose of this study was to analyze if the folate level and the gene expression levels of reduced folate carrier (RFC-1) and folylpolyglutamate synthase (FPGS) had impact on the expression of DCC splice variants...
  35. ncbi Loss of the putative tumor suppressor band 4.1B/Dal1 gene is dispensable for normal development and does not predispose to cancer
    Chunling Yi
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 25:10052-9. 2005
    ..These findings indicate that the 4.1B gene is not required for normal development and that 4.1B/Dal-1 does not function as a tumor suppressor gene...
  36. ncbi Antitumor effect of retinoic acid receptor-beta2 associated with suppression of cyclooxygenase-2
    Shumei Song
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Prev Res (Phila) 2:274-80. 2009
    ..Thus, further studies will determine whether manipulation of COX-2 expression in different cancers can antagonize RAR-beta2 activity...
  37. ncbi Genetic aberrations common in gastric high-grade large B-cell lymphoma
    P Starostik
    Institute of Pathology and Division of Medicine, Wuerzburg University, Wuerzburg, Germany
    Blood 95:1180-7. 2000
    ..Common genetic aberrations responsible for lymphomagenesis are deletions of 6q, loss of p53, and amplification of the 3q27 and the MLL gene regions. (Blood. 2000;95:1180-1187)..
  38. ncbi A dual-color FISH framework map for the characterization of the Sai1 tumor suppression region on rat chromosome 5
    K Helou
    CMB Genetics, Lundberg Laboratory, Goteborg University, Goteborg, Sweden
    Genes Chromosomes Cancer 27:362-72. 2000
    ..1) and Cd30lg (5q24.3). The framework map will provide the basis for the detailed physical YAC clone contig mapping of this region, and facilitate the identification and characterization of the Sai1 locus...
  39. ncbi Molecular genetic parameters in pathogenesis and prognosis of testicular germ cell tumors
    A Heidenreich
    Department of Urology, Philipps University, Marburg, Germany
    Eur Urol 37:121-35. 2000
    ..and prognosis of testicular germ cell tumors will not only help to better understand development and progression of testicular cancer, but it will also define new approaches to classification and management of germ cell tumors..
  40. ncbi Genetic modeling of human urinary bladder carcinogenesis
    B Czerniak
    Department of Pathology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Genes Chromosomes Cancer 27:392-402. 2000
    ..The approach used in this study facilitates genome-wide modeling of cancer progression and provides important chromosomal landmarks for more specific studies of multistep urinary bladder carcinogenesis...
  41. ncbi Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene
    Violetta Barbashina
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Clin Cancer Res 11:1119-28. 2005
    ..To better define the histologic correlates of different patterns of 1p and 19q loss, we evaluated 1p/19q status in a large group of gliomas. This also allowed us to define a very small minimal deleted region (MDR) on 1p36...
  42. ncbi TCEAL7, a putative tumor suppressor gene, negatively regulates NF-kappaB pathway
    R Rattan
    Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Oncogene 29:1362-73. 2010
    ....
  43. ncbi 3p21, 5q21, 9p21 and 17p13.1 allelic deletions are potential markers of individuals with a high risk of developing adenocarcinoma in Barrett's epithelium without dysplasia
    Julian Sanz-Ortega
    Departamento de Anatomía Patológica Hospital Clinico San Carlos, Martin Lagos s n, Madrid, Spain 28040
    Hepatogastroenterology 50:404-7. 2003
    ..We investigated 32 cases of Barrett's esophagus with no evidence of dysplasia for LOH at 5q21 (APC), 3p21, 9p21 (p16) and 17p13.1 (p53) chromosomal regions...
  44. ncbi [Loss of heterozygosity on chromosome 9p13-23 in microdissected laryngeal squamous cell carcinoma by microsatellite analysis]
    X Xu
    Department of Otorhinolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
    Zhonghua Er Bi Yan Hou Ke Za Zhi 36:367-71. 2001
    ..To refine the hot spots of LOH on chromosome 9p13-23 will be helpful to find other putative tumor suppressor genes in laryngeal squamous cell carcinoma...
  45. ncbi Localization and expression of p27KIP1 in multistage colorectal carcinogenesis
    M Ciaparrone
    Centro di Ricerche Oncologicalhe Giovanni XXXIII Università Cattolica del Sacro Cuore, Rome, Italy
    Cancer Res 58:114-22. 1998
    ..This may reflect the existence of a homeostatic feedback mechanism that is lost in the high-grade carcinomas that express low levels of p27Kip1...
  46. ncbi Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-beta
    O Cristina Micali
    Department of Plant Microbe Interactions, Max Planck Institute for Plant Breeding Research, Koeln, Germany
    BMC Cancer 7:52. 2007
    ..In this report, we investigated the role of basal xaf1 promoter methylation in xaf1 expression and assessed the responsiveness of cancer cell lines to XAF1 induction by IFN-beta...
  47. ncbi Assessment of NORE1A as a putative tumor suppressor in human neuroblastoma
    Janos Geli
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Int J Cancer 123:389-94. 2008
    ..Promotor methylation is not a common mechanism responsible for NORE1A transcriptional suppression in this tumor type...
  48. ncbi Single nucleotide polymorphisms of IGFBP-3 gene and lung cancer risk in a Korean population
    Sle Gi Lo Han
    Genomic Research Center for Lung and Breast Ovarian Cancers, Korea University Anam Hospital, Seoul, Republic of Korea
    Lung Cancer 62:152-61. 2008
    ..These results suggest that IGFBP-3 promoter polymorphisms of -1590 C>A and -202 A>C might be a genetic risk factor for lung cancer by means of decreased IGFBP-3 expression among females or never-smoking Koreans...
  49. ncbi The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers
    Stefan M Woerner
    Department of Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 220 221, D 69120 Heidelberg, Germany
    Genes Chromosomes Cancer 46:1080-9. 2007
    ....
  50. ncbi Hypoglycemia from IGF2 overexpression associated with activation of fetal promoters and loss of imprinting in a metastatic hemangiopericytoma
    Elizabeth A Lawson
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:2226-31. 2009
    ..The mechanism of IGF2 overexpression in non-islet-cell tumor hypoglycemia is not understood...
  51. ncbi Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation
    Franco Capozza
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Pathol 162:2029-39. 2003
    ..Our results provide the first genetic evidence that caveolin-1 indeed functions as a tumor suppressor gene in vivo...
  52. ncbi Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma
    Tomohiro Kondo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncogene 24:157-64. 2005
    ..These results indicate that LOH of PINX1 locus and hypoacetylation of histone H4 in the 5' UTR of PINX1 are associated with reduced expression of PINX1 in GC...
  53. ncbi Loss of expression of the putative tumor suppressor NES1 gene in biopsy-proven ductal carcinoma in situ predicts for invasive carcinoma at definitive surgery
    Michael J Yunes
    Department of Radiation Oncology, Division of Cancer and Radiation Biology, New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 56:653-7. 2003
    ..This study examined the expression level of NES1 in diagnostic biopsy samples found to contain pure DCIS. These data were then correlated with the pathologic findings found at definitive local surgery...
  54. ncbi Zinc-finger protein 331, a novel putative tumor suppressor, suppresses growth and invasiveness of gastric cancer
    J Yu
    Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    Oncogene 32:307-17. 2013
    ..In conclusion, our results suggest that ZNF331 possesses important functions for the suppression of gastric carcinogenesis as a novel functional tumor-suppressor gene...
  55. ncbi Prostate Cancer Risk in Relation to a Single Nucleotide Polymorphism in the Insulin-like Growth Factor-binding Protein-3 (IGFBP3) Gene: a Meta-analysis
    Ye Qing Mao
    Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China E mail
    Asian Pac J Cancer Prev 13:6299-303. 2012
    ..Considering the robustness of the results and the discrepancy among some studies, there might be some unsolved confounding factors, and further more critical large studies are needed for confirmation...
  56. ncbi The putative tumor suppressor gene PTPN13/PTPL1 induces apoptosis through insulin receptor substrate-1 dephosphorylation
    Mathilde Dromard
    INSERM U826, Contrôle de la progression des cancers hormono dépendants, Centre de Recherche en Cancerologie, Universite Montpellier I, CRLC Val d Aurelle Paul Lamarque, 34298 Montpellier, France
    Cancer Res 67:6806-13. 2007
    ..Altogether, these data provide the first evidence for a direct positive role of the putative tumor suppressor gene PTPL1/PTPN13 on apoptosis and identify its target in the IRS-1/PI3K/Akt signaling pathway...
  57. ncbi Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies
    Ana Puda
    Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
    Am J Hematol 87:245-50. 2012
    ..Our study suggests an essential role of the PRC2 complex in the leukemic transformation of chronic myeloid disorders...
  58. ncbi Transcription of the putative tumor suppressor gene HCCS1 requires binding of ETS-2 to its consensus near the transcription start site
    Jing De Zhu
    Laboratory of Cancer Epigenetics and Gene Therapy, The State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China
    Cell Res 16:780-96. 2006
    ..Our observations provide insight into the mechanistic aspects of HCCS1 transcription regulation...
  59. ncbi Gene expression and promoter methylation of the XIAP-associated Factor 1 in renal cell carcinomas: correlations with pathology and outcome
    Carsten Kempkensteffen
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Cancer Lett 254:227-35. 2007
    ..Promoter methylation may be one, but probably not the essential mechanism for transcriptional downregulation of the XAF1 gene in RCC...
  60. ncbi Down-regulation of S100A2 in lymph node metastases of head and neck cancer
    Xin Zhang
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA
    Head Neck 29:236-43. 2007
    ..S100A2, a putative tumor suppressor, has been found to be down-regulated in several types of primary tumor as compared with the normal tissue. Only a few reports have explored its expression status and function in metastasis...
  61. ncbi NOR1 is an HSF1- and NRF1-regulated putative tumor suppressor inactivated by promoter hypermethylation in nasopharyngeal carcinoma
    Wenjuan Li
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Xiangya Road, Changsha, Hunan 410078, China
    Carcinogenesis 32:1305-14. 2011
    ..Frequent epigenetic inactivation of the NOR1 gene in NPC suggests that it may be a critical tumor suppressor involved in the development of NPC...
  62. ncbi Common genetic variation in GATA-binding protein 3 and differential susceptibility to breast cancer by estrogen receptor alpha tumor status
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, Room 7076, MSC 7234, Rockville, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 16:2269-75. 2007
    ..These differential associations are consistent with markedly different levels of GATA3 protein by ER status. Additional epidemiologic studies are needed to clarify these intriguing relationships...
  63. ncbi Characterization of NOL7 gene point mutations, promoter methylation, and protein expression in cervical cancer
    Colleen L Doçi
    Department of Pathology, Medicine and Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA
    Int J Gynecol Pathol 31:15-24. 2012
    ..Together with evidence of its in vivo tumor suppression, these data support the hypothesis that NOL7 is the legitimate tumor suppressor gene located on 6p23...
  64. ncbi Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer
    Pierre Luc Mercier
    Department of Molecular Medicine, Laval University, Québec Québec, Canada
    Mol Oncol 5:438-53. 2011
    ..Further studies are needed to more completely elucidate the functional implications of DOK1 and other members of the DOK gene family in ovarian tumorigenesis...
  65. ncbi Epigenetic silencing of microRNA-203 dysregulates ABL1 expression and drives Helicobacter-associated gastric lymphomagenesis
    Vanessa J Craig
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Cancer Res 71:3616-24. 2011
    ..In summary, our results show that the transformation from gastritis to MALT lymphoma is epigenetically regulated by miR-203 promoter methylation and identify ABL1 as a novel target for the treatment of this malignancy...
  66. ncbi Tumor-associated methylation of the putative tumor suppressor AJAP1 gene and association between decreased AJAP1 expression and shorter survival in patients with glioma
    David Cogdell
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Chin J Cancer 30:247-53. 2011
    ..Thus, both genetic (gene deletion) and epigenetic alterations (promoter methylation) are likely mechanisms that inactivate the putative tumor suppressor AJAP1 in gliomas, which contributes to poor prognosis...
  67. ncbi A novel MECA3 region in human 3p21.3 harboring putative tumor suppressor genes and oncogenes
    E Braga
    Russian State Genetics Center, Moscow 117545 Russia
    Exp Oncol 33:33-41. 2011
    ..These cancers are responsible for 90% of cancer deaths...
  68. ncbi Transcriptional and post-translational regulation of the quiescence factor and putative tumor suppressor p150(Sal2)
    Chang K Sung
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    FASEB J 25:1275-83. 2011
    ..A CUL4/DDB1 E3 ligase containing RBBP7 as the p150(Sal2) receptor has been identified as mediating the destruction of p150(Sal2) as cells transition from a quiescent to an actively growing state...
  69. ncbi Systematic detection of putative tumor suppressor genes through the combined use of exome and transcriptome sequencing
    Qi Zhao
    Ludwig Collaborative Group, Department of Neurosurgery, Johns Hopkins University, 1550 Orleans Street, Baltimore, MD 21231, USA
    Genome Biol 11:R114. 2010
    ..The analysis was conducted on the breast cancer cell line HCC1954, and a lymphoblast cell line from the same individual, HCC1954BL...
  70. ncbi MicroRNA145 targets BNIP3 and suppresses prostate cancer progression
    Xueqin Chen
    Laboratory of Pathology, State Key Laboratory of Biotherapy and Department of Pathology, West China Hospital, West China Medical School, Sichuan University, China
    Cancer Res 70:2728-38. 2010
    ..Abnormalities of the miR145-BNIP3 pair as part of TP53-miR145-BNIP3-AIF network may play a major role in prostate cancer pathogenesis and progression...
  71. ncbi ECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma
    Silke Götze
    Max Planck Institut fur molekulare Physiologie, Dortmund, Germany
    BMC Cancer 9:447. 2009
    ..In turn, altered DNA methylation patterns have been used to identify putative tumor suppressor genes...
  72. ncbi Identification of the putative tumor suppressor Nit2 as omega-amidase, an enzyme metabolically linked to glutamine and asparagine transamination
    Boris F Krasnikov
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Biochimie 91:1072-80. 2009
    ....
  73. ncbi Evidence for polyclonal origin of multifocal clear cell renal cell carcinoma
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 14:8087-93. 2008
    ..Renal cell carcinomas are often multifocal. We investigated the genomic signatures of multifocal clear cell renal cell carcinoma to determine whether multiple tumors in the same kidney bear a clonal relationship to one another...
  74. ncbi LIM domain protein TES changes its conformational states in different cellular compartments
    Yingli Zhong
    Key Laboratory of Protein Chemistry and Developmental Biology of Education Ministry of China, College of Life Science, Hunan Normal University, Changsha, Hunan 410081, People s Republic of China
    Mol Cell Biochem 320:85-92. 2009
    ..Taken together, our results suggest that TES has different conformational states in different cellular compartments, and a "closed" conformational state of TES may be involved in nucleolar localization...
  75. ncbi [Mapping of a deletion interval on 8p21-22 in prostate cancer by gene dosage PCR]
    H Schmidt
    Gerhard Domagk Institut für Pathologie, Universitäitsklinikum Münster
    Verh Dtsch Ges Pathol 91:302-7. 2007
    ..LOXL2 is frequently expressed in proliferating tissues and shows a high expression in benign prostate tissue too. In prostate cancer the expression is positive correlated with the MIB1-score...
  76. ncbi DCC promoter hypermethylation in esophageal squamous cell carcinoma
    Hannah Lui Park
    Department of Otolaryngology, Division of Head and Neck Cancer Research, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Int J Cancer 122:2498-502. 2008
    ..We have demonstrated that DCC methylation is a frequent and cancer-specific event in primary ESCCs, suggesting that DCC and associated pathways may represent a new diagnostical therapeutic target...
  77. ncbi Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells
    Yong Pan
    Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Fannin Street, Houston, Texas 77054, USA
    Breast Cancer Res 10:R5. 2008
    ....
  78. ncbi Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin
    I Wolf
    The Institute of Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel
    Oncogene 29:26-33. 2010
    ..These data suggest KL-VS as a breast and ovarian cancer risk modifier among BRCA1 mutation carriers. If validated in additional cohorts, the presence of KL-VS may serve as a predictor of cancer risk among BRCA1 mutation carriers...
  79. ncbi CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component
    Sanjay Kakar
    Department of Pathology, Veteran Affairs Medical Center and University of California at San Francisco, San Francisco, CA 94121, USA
    Hum Pathol 39:30-6. 2008
    ..Methylation of MGMT and RASSF2 increases during the progression from tubular adenoma to tubulovillous/villous adenoma. BRAF mutations are absent in tubulovillous/villous adenomas...
  80. ncbi Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population
    Hirotaka Kanzaki
    Department of Molecular Genetics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700 8558, Japan
    Int J Mol Med 18:279-84. 2006
    ..This is the first report to show an association between the AXIN2 SNP and lung cancer risk...
  81. ncbi Association of rat p15INK4B/p16INK4 deletions with monosomy 5 in kidney epithelial cell lines but not primary renal tumors
    D F Knapek
    University of Texas M D Anderson Cancer Center, Smithville 78957, USA
    Cancer Res 55:1607-12. 1995
    ....
  82. ncbi In acute lymphoblastic leukemia deletion of the tumor suppressor gene P16 is associated with abnormal interferon genes
    G Sternik
    Laboratorio de Biología Celular y Retrovirus, Hospital Nacional de Pediatria Juan P Garrahan, Buenos Aires, Argentina
    Medicina (B Aires) 58:463-8. 1998
    ..Therefore, p16 gene deletion with preserved type I interferon genes in some ALL suggests that the absence of this cdk inhibitor may disturb the normal cell cycle and favor blast transformation...
  83. ncbi Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32
    T Nishiwaki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Genes Chromosomes Cancer 27:169-76. 2000
    ..Genes Chromosomes Cancer 27:169-176, 2000...
  84. ncbi Allelic expression of the putative tumor suppressor gene p73 in human fetal tissues and tumor specimens
    J F Hu
    GRECC and Medical Service, VA Palo Alto Health Care System, and Division of Endocrinology, Department of Medicine, Stanford University, Palo Alto, CA, USA
    Biochim Biophys Acta 1491:49-56. 2000
    ..1%) Wilms' tumors. These data demonstrate that p73 is biallelically expressed in most tissues, thus excluding genomic imprinting as a molecular mechanism to predispose to allelic inactivation of p73 in human tumors...
  85. ncbi 11q23 allelic loss is associated with regional lymph node metastasis in melanoma
    R A Herbst
    Department of Dermatology and Allergology, Hannover Medical University, Germany
    Clin Cancer Res 6:3222-7. 2000
    ..These findings support our conclusion and give additional evidence for the hypothesis of molecular heterogeneity of early tumor cell populations in melanoma...
  86. ncbi Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinoma
    C Liao
    Shanghai Institute of Biochemistry, Chinese Academy of Sciences, Shanghai, P R China
    Hepatology 32:721-7. 2000
    ..Several AS-ODNs specific for LPTS mRNA significantly enhanced cell growth, whereas control oligodeoxynucleotides (ODNs) did not. Our results suggest that LPTS might be a growth-inhibitory protein in human hepatocytes...
  87. ncbi Localization of tumor suppressor activity important in nonsmall cell lung carcinoma on chromosome 11q
    Y Murakami
    Oncogene Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Proc Natl Acad Sci U S A 95:8153-8. 1998
    ..This complementation approach localized tumor suppression activity to the central 700 kb of 939b12 and provides a functional assay for positional cloning of this tumor suppressor gene...
  88. ncbi Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers
    R Dammann
    Department of Biology, Beckman Research Institute, City of Hope Cancer Center, Duarte, California 91010, USA
    Cancer Res 61:3105-9. 2001
    ..No somatic mutations were found in the samples that were unmethylated. The data suggest that hypermethylation of the CpG island promoter of RASSF1A may play an important role in breast cancer pathogenesis...
  89. ncbi Homozygous deletions on the short arm of chromosome 3 in human oral squamous cell carcinomas
    N Uzawa
    Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, 113 8549, Tokyo, Japan
    Oral Oncol 37:351-6. 2001
    ..Therefore, several candidate tumor suppressor genes, including the FHIT gene, may reside in these homozygously deleted regions. To our knowledge, this is the first report of HDs on 3p in OSCCs...
  90. ncbi Chromosome bands 3p14.2, 9p21, and 13q14 are frequently deleted in roentgenographically occult bronchogenic squamous cell carcinoma of the lung
    M Sato
    Department of Thoracic Surgery, Institute of Development, Aging, and Cancer, and Tohoku University School of Medicine, Sendai, Japan
    Genes Chromosomes Cancer 23:367-70. 1998
    ..2, 9p21, and 13q14.12-q14.2 represent rather early events in lung carcinogenesis; and (3) mutations in genes on 10q25.3-q26.1 and 16q24.1-q24.2 represent rather late events...
  91. ncbi Rare loss-of-function mutation of a death receptor gene in head and neck cancer
    S I Pai
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University, Baltimore, Maryland 21205 2196, USA
    Cancer Res 58:3513-8. 1998
    ..These observations provide the first evidence for mutation of a TRAIL death receptor gene in a human cancer, leading to loss of its apoptotic function...
  92. ncbi A Jun-binding protein related to a putative tumor suppressor
    F S Monteclaro
    Department of Microbiology, University of Southern California School of Medicine, Los Angeles
    Proc Natl Acad Sci U S A 90:6726-30. 1993
    ..Addition of Fos protein to Jun-Jif-1 complexes restores DNA-binding activity. These observations suggest that Jif-1 is a negative regulator of Jun...
  93. ncbi Antisense RNA to the putative tumor suppressor gene BRCA1 transforms mouse fibroblasts
    V N Rao
    Department of Microbiology and Immunology, Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5541, USA
    Oncogene 12:523-8. 1996
    ..These results provide the first direct biological evidence for the possible function of BRCA1 as a tumor suppressor gene...
  94. ncbi Enhanced expression in spleen macrophages of the mouse homolog to the human putative tumor suppressor gene ZFM1
    C Wrehlke
    Division of Molecular Parasitology and Centre for Biological and Medical Research, Heinrich Heine University, Duesseldorf, Germany
    DNA Cell Biol 16:761-7. 1997
    ..The different MZFM-isoforms may be part of a macrophage-inherent program of transduction of environmental signals into different activational states of macrophages...
  95. ncbi Loss of heterozygosity analysis in primary mammary tumors and lung metastases of MMTV-MTAg and MMTV-neu transgenic mice
    S R Ritland
    Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale 85259, USA
    Cancer Res 57:3520-5. 1997
    ....
  96. ncbi MXI1, a putative tumor suppressor gene, suppresses growth of human glioblastoma cells
    D S Wechsler
    Department of Pediatrics and Communicable Diseases, University of Michigan School of Medicine, Ann Arbor 48109, USA
    Cancer Res 57:4905-12. 1997
    ..Thus, these studies support the notion that MXI1 normally functions to suppress cell growth and suggest that loss of MXI1 function may play a role in human glioblastoma development...
  97. ncbi Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia
    Y Liu
    Radiumhemmet, Karolinska Hospital, Stockholm, Sweden
    Oncogene 15:2463-73. 1997
    ..We conclude that the Leu1 and Leu2 genes are strong candidates as tumor suppressor gene(s) involved in B-CLL leukemogenesis...
  98. ncbi Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines
    S K Kim
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Oncogene 16:89-93. 1998
    ..Our data suggest that inactivation of PTEN/ MMAC1 is a rare event in SCLC tumorigenesis. However, the PTEN/MMAC1 homologue PTH2 may play a role in SCLC tumorigenesis...
  99. ncbi Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33
    T Habuchi
    Molecular Genetics Laboratory, Marie Curie Research Institute, Oxted, Surrey, United Kingdom
    Genomics 48:277-88. 1998
    ..These findings make DBCCR1 a good candidate for DBC1...
  100. ncbi Analysis of genomic imprinting at 1p35-36 in neuroblastoma
    M D Hogarty
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania 19104 4318, USA
    Med Pediatr Oncol 36:52-5. 2001
    ..2-36.3. Indirect evidence suggests the presence of an imprinted neuroblastoma suppressor gene within this region, as well as an additional nonimprinted, proximal suppressor gene, inactivation of which correlates with MYCN amplification...
  101. ncbi Isolation and characterization of a novel cDNA, UBAP1, derived from the tumor suppressor locus in human chromosome 9p21-22
    J Qian
    Cancer Research Institute, Human Medical University, Changsha, PR China
    J Cancer Res Clin Oncol 127:613-8. 2001
    ..To clone the putative tumor suppressor gene(s) in a refined region at 9p21-22 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC)...

Research Grants77

  1. Characterization of Human 3p Recessive Oncogenes
    John Minna; Fiscal Year: 2004
    ..mutation, suppression of the malignant phenotype) including CACNA2D2, 101F6, NPR21/G21, BLU, FUSI, HYAL1, and FUS2. The current proposal will: Confirm the tumor suppressing function of RASSF1A and SEMA3B and further implicate or ..
  2. 17Q25 BREAST CANCER GENE--ISOLATION AND ANALYSIS
    ELIZABETH PETTY; Fiscal Year: 1999
    ....
  3. Use of RNAi to investigate cullin-5 function in breast cancer
    Michael Fay; Fiscal Year: 2006
    ..A better understanding of cancer-related genes, such as Cul5, is expected to lead to better therapies for patients. ..
  4. Detection of Novel Gene Defects in Basal Cell Carcinoma
    Steven Fakharzadeh; Fiscal Year: 2005
    ..abstract_text> ..
  5. SIGNALING MECHANISM IN DCC-INDUCED APOPTOSIS
    Yong Chen; Fiscal Year: 2003
    ....
  6. DNA methylation patterns as biomarker for breast cancer
    Kristin Skinner; Fiscal Year: 2003
    ..These future studies will determine whether DNA methylation changes can be used a) to stratify women at risk for breast cancer and b) as a surrogate endpoint in chemoprevention trials. ..
  7. MECHANISMS OF ENZYMATIC REACTIONS
    PERRY FREY; Fiscal Year: 2002
    ..Crystallization trials will be pursued with the objective of determining the first structured in the Ga1K family of sugar phosphotransferases. ..
  8. CLONING NOVEL GENES FOR PAGETS DISEASE AND OSTEOSARCOMA
    Marc Hansen; Fiscal Year: 2001
    ....
  9. Role of POZ-zinc finger proteins in tumorigenesis.
    Pier Paolo Pandolfi; Fiscal Year: 2011
    ..In view of the critical role exerted by this protein in tumorigenesis and embryonic development the further elucidation of POKEMON/LRF function and role in human cancer is of great relevance to biomedical research. ..
  10. Role of POZ-zinc finger proteins in tumorigenesis.
    Pier Paolo Pandolfi; Fiscal Year: 2010
    ..In view of the critical role exerted by this protein in tumorigenesis and embryonic development the further elucidation of POKEMON/LRF function and role in human cancer is of great relevance to biomedical research. ..
  11. MECHANISMS OF ENZYMATIC REACTIONS
    PERRY FREY; Fiscal Year: 2006
    ..Research on Fhit is directed toward elucidating its chemical reaction mechanism and the chemical basis for its activity as a tumor suppressor and its mechanistic relationships with galactose-1-P uridylyltransferase. ..
  12. Investigation of Notch-inhibiting microRNAs in glioma
    Benjamin W Purow; Fiscal Year: 2010
    ..In this proposal, we will investigate two microRNAs as tumor suppressors and therapies in glioma secondary to their inhibition of the Notch pathway, a central pathway in stem cells, cell fate, and cancer. ..
  13. Role of Caveolin-1 and eNOS in Mediating the Therapeutic Effects of CO in PAH.
    PHILIP BAUER; Fiscal Year: 2009
    ..Upon completion of the proposed research we will have a better foundation upon which to investigate the novel therapeutic use of inhaled CO in this debilitating disease. ..
  14. Role of Caveolin-1 and eNOS in Mediating the Therapeutic Effects of CO in PAH.
    Philip M Bauer; Fiscal Year: 2010
    ..Upon completion of the proposed research we will have a better foundation upon which to investigate the novel therapeutic use of inhaled CO in this debilitating disease. ..
  15. Semaphorin 3F: Structure, Function, and Anti-Metastatic Activity
    Diane Bielenberg; Fiscal Year: 2007
    ..Most of all, a Howard Temin Award would enable the continuation of this research project toward the ultimate goal of long-term stable disease. ..
  16. BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    Joseph Wiemels; Fiscal Year: 2006
    ..We are ultimately working to elucidate the origin and causes of a cancer that might be preventable. ..