NAT2

Summary

Gene Symbol: NAT2
Description: N-acetyltransferase 2
Alias: AAC2, NAT-2, PNAT, arylamine N-acetyltransferase 2, N-acetyltransferase 2 (arylamine N-acetyltransferase), N-acetyltransferase type 2, arylamide acetylase 2
Species: human
Products:     NAT2

Top Publications

  1. Ochs Balcom H, Wiesner G, Elston R. A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer. Am J Epidemiol. 2007;166:246-54 pubmed
    The N-acetyltransferase 2 gene (NAT2) product is an enzyme important in carcinogen metabolism via activation and detoxification pathways. Therefore, NAT2 variants may represent underlying susceptibility to breast cancer...
  2. Luca F, Bubba G, Basile M, Brdicka R, Michalodimitrakis E, Rickards O, et al. Multiple advantageous amino acid variants in the NAT2 gene in human populations. PLoS ONE. 2008;3:e3136 pubmed publisher
    Genetic variation at NAT2 has been long recognized as the cause of differential ability to metabolize a wide variety of drugs of therapeutic use...
  3. Kiyohara C, Washio M, Horiuchi T, Tada Y, Asami T, Ide S, et al. Cigarette smoking, N-acetyltransferase 2 polymorphisms and systemic lupus erythematosus in a Japanese population. Lupus. 2009;18:630-8 pubmed publisher
    ..N-acetyltransferase 2 (NAT2) is highly variable and detoxifies aromatic amines, an important class of carcinogens in tobacco smoke...
  4. Sabbagh A, Darlu P, Crouau Roy B, Poloni E. Arylamine N-acetyltransferase 2 (NAT2) genetic diversity and traditional subsistence: a worldwide population survey. PLoS ONE. 2011;6:e18507 pubmed publisher
    Arylamine N-acetyltransferase 2 (NAT2) is involved in human physiological responses to a variety of xenobiotic compounds, including common therapeutic drugs and exogenous chemicals present in the diet and the environment...
  5. Zang Y, Doll M, Zhao S, States J, Hein D. Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2. Carcinogenesis. 2007;28:1665-71 pubmed
    Human N-acetyltransferase 2 (NAT2) is polymorphic in humans and may associate with cancer risk by modifying individual susceptibility to cancers from carcinogen exposure...
  6. Demokan S, Suoglu Y, Gözeler M, Demir D, Dalay N. N-acetyltransferase 1 and 2 gene sequence variants and risk of head and neck cancer. Mol Biol Rep. 2010;37:3217-26 pubmed publisher
    ..In this study the role of genetically determined individual NAT1 and NAT2 genotypes, haplotypes and haplotype combinations in the predisposition to head and neck cancer was investigated...
  7. Jiao L, Doll M, Hein D, Bondy M, Hassan M, Hixson J, et al. Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2007;16:2379-86 pubmed
    We examined the association between N-acetyltransferase 1 and 2 (NAT1 and NAT2) haplotype and risk of pancreatic cancer by genotyping eight NAT1 and seven NAT2 single nucleotide polymorphisms in 532 patients and in 581 healthy controls (..
  8. Boukouvala S, Sim E. Structural analysis of the genes for human arylamine N-acetyltransferases and characterisation of alternative transcripts. Basic Clin Pharmacol Toxicol. 2005;96:343-51 pubmed
    Arylamine N-acetyltransferases are polymorphic drug-metabolising enzymes. The human isoforms, NAT1 and NAT2, are encoded by two genes with intronless coding regions...
  9. Chen K, Jiang Q, He H. Relationship between metabolic enzyme polymorphism and colorectal cancer. World J Gastroenterol. 2005;11:331-5 pubmed
    ..Meta analysis of these studies showed that GSTT1 deletion (pooled OR = 1.42), N-acetyltransferase 2 (NAT2)-rapid acetylator phenotype and genotye (pooled OR = 1.08) and NAT2-rapid acetylator phenotype (pooled OR = 1...

More Information

Publications115 found, 100 shown here

  1. Bose P, Sarma M, Medhi S, Das B, Husain S, Kar P. Role of polymorphic N-acetyl transferase2 and cytochrome P4502E1 gene in antituberculosis treatment-induced hepatitis. J Gastroenterol Hepatol. 2011;26:312-8 pubmed publisher
    ..The present study was aimed at investigating the role of the N-acetyltransferase2 (NAT2) and cytochrome P4502E1 (CYP2E1) gene polymorphisms in ATT hepatotoxicity...
  2. Bakayev V, Mohammadi F, Bahadori M, Sheikholslami M, Javeri A, Masjedi M, et al. Arylamine N-acetyltransferase 2 slow acetylator polymorphisms in unrelated Iranian individuals. Eur J Clin Pharmacol. 2004;60:467-71 pubmed
    To determine the frequency of mutations at the polymorphic gene coding for arylamine N-acetyltransferase 2 (NAT2, EC 2.3.1.5) and NAT2 genotypes associated with slow acetylation in healthy Iranian individuals...
  3. da Silva T, Felipe A, de Lima J, Oshima C, Forones N. N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer. World J Gastroenterol. 2011;17:760-5 pubmed publisher
    To investigate the possible association between meat intake, cigarette smoking and N-acetyltransferase 2 (NAT2) genetic polymorphisms on colorectal cancer (CRC) risk. Patients with CRC were matched for gender and age to healthy controls...
  4. Talbot J, Magno L, Santana C, Sousa S, Melo P, Correa R, et al. Interethnic diversity of NAT2 polymorphisms in Brazilian admixed populations. BMC Genet. 2010;11:87 pubmed publisher
    N-acetyltransferase type 2 (Nat2) is a phase II drug- metabolizing enzyme that plays a key role in the bioactivation of aromatic and heterocyclic amines...
  5. Sørensen M, Autrup H, Olsen A, Tjønneland A, Overvad K, Raaschou Nielsen O. Prospective study of NAT1 and NAT2 polymorphisms, tobacco smoking and meat consumption and risk of colorectal cancer. Cancer Lett. 2008;266:186-93 pubmed publisher
    Heterocyclic amines in tobacco smoke and fried meat are activated or detoxified by N-acetyltransferases (NAT1 and NAT2). We identified 379 cases with colorectal cancer (CRC) and 769 sub-cohort members among a cohort of 57,000 members...
  6. Terry P, Goodman M. Is the association between cigarette smoking and breast cancer modified by genotype? A review of epidemiologic studies and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2006;15:602-11 pubmed
    ..In particular, 14 epidemiologic studies have tended to show positive associations with long-term smoking among NAT2 slow acetylators, especially among postmenopausal women...
  7. Baranska M, Trzcinski R, Dziki A, Rychlik Sych M, Dudarewicz M, Skretkowicz J. The role of N-acetyltransferase 2 polymorphism in the etiopathogenesis of inflammatory bowel disease. Dig Dis Sci. 2011;56:2073-80 pubmed publisher
    ..The arylamine N-acetyltransferase 2 (NAT2) enzyme detoxifies a wide spectrum of naturally occurring xenobiotics including carcinogens and drugs...
  8. Tamer L, Tursen U, Eskandari G, Ates N, Ercan B, Yildirim H, et al. N-acetyltransferase 2 polymorphisms in patients with Behcet's disease. Clin Exp Dermatol. 2005;30:56-60 pubmed
    ..induce an autoimmune mechanism, the aim of the present study was to investigate whether the genetic polymorphism of NAT2 plays a role in susceptibility to Behcet's disease...
  9. Cui D, Wang Z, Zhao E, Ma J, Lu W. NAT2 polymorphism and lung cancer risk: a meta-analysis. Lung Cancer. 2011;73:153-7 pubmed publisher
    N-acetyltransferase 2 (NAT2) gene encodes a key enzyme involved in the metabolism of xenobiotics and whose polymorphisms have been related to individual susceptibility to several malignancies...
  10. Kuhn U, Anschütz M, Schmücker K, Schug B, Hippius M, Blume H. Phenotyping with sulfasalazine - time dependence and relation to NAT2 pharmacogenetics. Int J Clin Pharmacol Ther. 2010;48:1-10 pubmed
    N-acetyltransferase 2 (NAT2) genotype-phenotype relation with sulfasalazine as probe drug by means of detailed genotype analysis and kinetic data evaluation...
  11. Hiratsuka M, Kishikawa Y, Takekuma Y, Matsuura M, Narahara K, Inoue T, et al. Genotyping of the N-acetyltransferase2 polymorphism in the prediction of adverse drug reactions to isoniazid in Japanese patients. Drug Metab Pharmacokinet. 2002;17:357-62 pubmed
    To investigate the association between NAT2 genotypes and the incidence of isoniazid (INH)-induced adverse reactions, in the hope of identifying a pharmacogenetic approach that could be useful in the prediction and prevention of adverse ..
  12. Lv X, Tang S, Xia Y, Zhang Y, Wu S, Yang Z, et al.  NAT2 genetic polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in Chinese community population. Ann Hepatol. 2012;11:700-7 pubmed
    ..Some researchers suggested that determination of N-acetyltransferase 2 (NAT2) genotype may be clinically useful to identify patients at high risk of developing ATDH...
  13. Zhou X, Ma Z, Dong D, Wu B. Arylamine N-acetyltransferases: a structural perspective. Br J Pharmacol. 2013;169:748-60 pubmed publisher
    ..Furthermore, the structural elucidation of NATs has generated powerful tools in the design of small molecule inhibitors that should alleviate cancer, based on the important role of the enzyme in cancer biology. ..
  14. Torkaman Boutorabi A, Hoormand M, Naghdi N, Bakhshayesh M, Milanian I. Genotype and allele frequencies of N-acetyltransferase 2 and glutathione S-transferase in the Iranian population. Clin Exp Pharmacol Physiol. 2007;34:1207-11 pubmed
    ..of the present study was to determine the frequencies of important allelic variants in the N-acetyltransferase 2 (NAT2) and glutathione S-transferase (GST) genes in the Iranian population and compare them with frequencies in other ..
  15. Leiro Fernández V, Valverde D, Vázquez Gallardo R, Botana Rial M, Constenla L, Agundez J, et al. N-acetyltransferase 2 polymorphisms and risk of anti-tuberculosis drug-induced hepatotoxicity in Caucasians. Int J Tuberc Lung Dis. 2011;15:1403-8 pubmed publisher
    To analyse slow-acetylation N-acetyltransferase 2 (NAT2) polymorphisms for their association with the risk of anti-tuberculosis drug-induced hepatotoxicity (ATDH)...
  16. Donald P, Sirgel F, Venter A, Parkin D, Seifart H, van de Wal B, et al. The influence of human N-acetyltransferase genotype on the early bactericidal activity of isoniazid. Clin Infect Dis. 2004;39:1425-30 pubmed
    The elimination of isoniazid is subject to the influence of the N-acetyltransferase 2 (NAT2) genotype, and individuals may be homozygotic slow, heterozygotic fast, or homozygotic fast acetylators of isoniazid...
  17. Ambrosone C, Kropp S, Yang J, Yao S, Shields P, Chang Claude J. Cigarette smoking, N-acetyltransferase 2 genotypes, and breast cancer risk: pooled analysis and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2008;17:15-26 pubmed publisher
    ..10 years ago, it was noted that smoking increased risk of breast cancer among women with N-acetyltransferase 2 (NAT2) slow acetylation genotypes. This report was followed by a number of studies to address this question...
  18. Alberg A, Daudt A, Huang H, Hoffman S, Comstock G, Helzlsouer K, et al. N-acetyltransferase 2 (NAT2) genotypes, cigarette smoking, and the risk of breast cancer. Cancer Detect Prev. 2004;28:187-93 pubmed
    N-acetyltransferases (NATs) are important catalytic enzymes that metabolize carcinogenic arylamines. NAT2 genotype might modify the role of cigarette smoking, a source of arylamine exposure, in breast cancer...
  19. Costa S, Pinto D, Morais A, Vasconcelos A, Oliveira J, Lopes C, et al. Acetylation genotype and the genetic susceptibility to prostate cancer in a southern European population. Prostate. 2005;64:246-52 pubmed
    ..We used PCR-RFLP method to analyze NAT 1 and NAT 2 polymorphisms...
  20. Ma J, Liu C, Li J, Cao X, Sun S, Yao X. Effects of NAT2 polymorphism on SASP pharmacokinetics in Chinese population. Clin Chim Acta. 2009;407:30-5 pubmed publisher
    ..Sulfasalazine (SASP) pharmacologic actions are widely applied in clinical therapy. The role of N-Acetyltransferase 2 (NAT2) in the pharmacokinetics of SASP and its metabolites has not been clarified...
  21. Pistorius S, Goergens H, Engel C, Plaschke J, Krueger S, Hoehl R, et al. N-Acetyltransferase (NAT) 2 acetylator status and age of tumour onset in patients with sporadic and familial, microsatellite stable (MSS) colorectal cancer. Int J Colorectal Dis. 2007;22:137-43 pubmed
    ..Allelic variants of the NAT2 gene are determined by a pattern of single nucleotide polymorphisms (SNPs) resulting in slow (SA), intermediate (IA)..
  22. Garcia Martin E. Interethnic and intraethnic variability of NAT2 single nucleotide polymorphisms. Curr Drug Metab. 2008;9:487-97 pubmed
    Genetic polymorphisms of human arylamine N-acetyltransferase 2 (NAT2) are responsible for interindividual variation in the acetylation of numerous drugs and in the transformation of aromatic and heterocyclic amines into carcinogenic ..
  23. Zhang J, Qiu L, Wang Z, Wang J, He S, Hu X. NAT2 polymorphisms combining with smoking associated with breast cancer susceptibility: a meta-analysis. Breast Cancer Res Treat. 2010;123:877-83 pubmed publisher
    ..precise estimation of the relationship between the slow or rapid acetylation resulting from N-acetyltransferase 2 (NAT2) polymorphisms and breast cancer risk, a meta-analysis was performed...
  24. Teixeira R, Morato R, Cabello P, Muniz L, Moreira A, Kritski A, et al. Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients. Mem Inst Oswaldo Cruz. 2011;106:716-24 pubmed
    ..Differences in INH-induced toxicity have been attributed to genetic variability at several loci, such as NAT2, CYP2E1, GSTM1 and GSTT1, that code for drug-metabolising enzymes...
  25. Bailliet G, Santos M, Alfaro E, Dipierri J, Demarchi D, Carnese F, et al. Allele and genotype frequencies of metabolic genes in Native Americans from Argentina and Paraguay. Mutat Res. 2007;627:171-7 pubmed
    Interethnic differences in the allele frequencies of CYP2D6, NAT2, GSTM1 and GSTT1 deletions have been documented for Caucasians, Asians, and Africans population...
  26. Majumder M, Sikdar N, Ghosh S, Roy B. Polymorphisms at XPD and XRCC1 DNA repair loci and increased risk of oral leukoplakia and cancer among NAT2 slow acetylators. Int J Cancer. 2007;120:2148-56 pubmed
    Polymorphisms at N-acetyl transferase 2 locus (NAT2) lead to slow, intermediate and rapid acetylation properties of the enzyme. Improper acetylation of heterocyclic and aromatic amines, present in tobacco, might cause DNA adduct formation...
  27. Sanderson S, Salanti G, Higgins J. Joint effects of the N-acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesis. Am J Epidemiol. 2007;166:741-51 pubmed
    ..review and evidence synthesis, the authors investigated the joint effects of the N-acetyltransferase genes NAT1 and NAT2 and cigarette smoking on bladder carcinogenesis...
  28. Nöthlings U, Yamamoto J, Wilkens L, Murphy S, Park S, Henderson B, et al. Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev. 2009;18:2098-106 pubmed publisher
    ..We investigated the modifying effects of NAT1 and NAT2 polymorphisms on the association of meat consumption, heterocyclic amine intake, and smoking with colorectal cancer ..
  29. Suhre K, Wallaschofski H, Raffler J, Friedrich N, Haring R, Michael K, et al. A genome-wide association study of metabolic traits in human urine. Nat Genet. 2011;43:565-9 pubmed publisher
    ..have previously been linked with important clinical outcomes: SLC7A9 is a risk locus for chronic kidney disease, NAT2 for coronary artery disease and genotype-dependent response to drug toxicity, and SLC6A20 for iminoglycinuria...
  30. Selinski S, Blaszkewicz M, Lehmann M, Ovsiannikov D, Moormann O, Guballa C, et al. Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype. Pharmacogenet Genomics. 2011;21:673-8 pubmed publisher
    Genotyping N-acetyltransferase 2 (NAT2) is of high relevance for individualized dosing of antituberculosis drugs and bladder cancer epidemiology...
  31. Chen K, Jin M, Fan C, Song L, Jiang Q, Yu W, et al. [A case-control study on the association between genetic polymorphisms of metabolic enzymes and the risk of colorectal cancer]. Zhonghua Liu Xing Bing Xue Za Zhi. 2005;26:659-64 pubmed
    ..polymorphisms of CYP1A1 6235T/C, CYP1A2 734C/A, CYP2E1 -1259G/C, CYP2E1 -1019C/T, GSTM1 and T1 null type, NAT1 and NAT2 alleles among 140 cases and 343 cancer-free controls...
  32. Moslehi R, Chatterjee N, Church T, Chen J, Yeager M, Weissfeld J, et al. Cigarette smoking, N-acetyltransferase genes and the risk of advanced colorectal adenoma. Pharmacogenomics. 2006;7:819-29 pubmed
    ..N-acetyltransferases, NAT1 and NAT2, are important enzymes involved in the metabolism of aromatic amine carcinogens present in cigarette smoke...
  33. Chen M, Xia B, Chen B, Guo Q, Li J, Ye M, et al. N-acetyltransferase 2 slow acetylator genotype associated with adverse effects of sulphasalazine in the treatment of inflammatory bowel disease. Can J Gastroenterol. 2007;21:155-8 pubmed
    N-acetyltransferase 2 (NAT2) is an important enzyme catalyzing N-acetylation of sulfasalazine (SASP)...
  34. Yoshida K, Osawa K, Kasahara M, Miyaishi A, Nakanishi K, Hayamizu S, et al. Association of CYP1A1, CYP1A2, GSTM1 and NAT2 gene polymorphisms with colorectal cancer and smoking. Asian Pac J Cancer Prev. 2007;8:438-44 pubmed
    We investigated CYP1A1*2A, CYP1A1*2C, CYP1A2*1C, CYP1A2*1F, GSTM1 and NAT2 gene polymorphisms, involving enzymes which metabolize many carcinogens, with reference to colorectal cancer risk...
  35. Sabbagh A, Langaney A, Darlu P, Gerard N, Krishnamoorthy R, Poloni E. Worldwide distribution of NAT2 diversity: implications for NAT2 evolutionary history. BMC Genet. 2008;9:21 pubmed publisher
    The N-acetyltransferase 2 (NAT2) gene plays a crucial role in the metabolism of many drugs and xenobiotics...
  36. Walraven J, Zang Y, Trent J, Hein D. Structure/function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2. Curr Drug Metab. 2008;9:471-86 pubmed
    Arylamine N-acetyltransferase 2 (NAT2) modifies drug efficacy/toxicity and cancer risk due to its role in bioactivation and detoxification of arylamine and hydrazine drugs and carcinogens...
  37. Hernandez A, Xamena N, Gutierrez S, Velázquez A, Creus A, Surralles J, et al. Basal and induced micronucleus frequencies in human lymphocytes with different GST and NAT2 genetic backgrounds. Mutat Res. 2006;606:12-20 pubmed
    ..NAT) genes have been associated with cancer risk, we explored the possible links between GSTM1, GSTP1, GSTT1 and NAT2 variants and the frequency of micronuclei (MN) in human lymphocytes...
  38. Borlak J, Reamon Buettner S. N-acetyltransferase 2 (NAT2) gene polymorphisms in colon and lung cancer patients. BMC Med Genet. 2006;7:58 pubmed
    N-acetyltransferase 2 (NAT2) metabolizes arylamines and hydrazines moeities found in many therapeutic drugs, chemicals and carcinogens. The gene encoding NAT2 is polymorphic, thus resulting in rapid or slow acetylator phenotypes...
  39. Osian G, Procopciuc L, Vlad L. NAT2 gene polymorphism and sporadic colorectal cancer. Prevalence, tumor stage and prognosis. A preliminary study in 70 patients. J Gastrointestin Liver Dis. 2006;15:347-53 pubmed
    Theoretically, individuals with a NAT2 rapid acetylator genotype are exposed to a higher risk of developing colorectal cancer. We attempted to study this relationship...
  40. Zang Y, Zhao S, Doll M, States J, Hein D. Functional characterization of the A411T (L137F) and G364A (D122N) genetic polymorphisms in human N-acetyltransferase 2. Pharmacogenet Genomics. 2007;17:37-45 pubmed
    Human N-acetyltransferase 2 (NAT2) genetic polymorphisms may modify drug efficacy and toxicity and cancer susceptibility from carcinogen exposure. Two human NAT2 alleles, NAT2*5I and NAT2*12D, were identified recently...
  41. Kubota R, Ohno M, Hasunuma T, Iijima H, Azuma J. Dose-escalation study of isoniazid in healthy volunteers with the rapid acetylator genotype of arylamine N-acetyltransferase 2. Eur J Clin Pharmacol. 2007;63:927-33 pubmed
    Genetic polymorphisms of arylamine N-acetyltransferase 2 (NAT2) result in large interindividual differences in the plasma concentration of isoniazid (INH)...
  42. McKay J, Hashibe M, Hung R, Wakefield J, Gaborieau V, Szeszenia Dabrowska N, et al. Sequence variants of NAT1 and NAT2 and other xenometabolic genes and risk of lung and aerodigestive tract cancers in Central Europe. Cancer Epidemiol Biomarkers Prev. 2008;17:141-7 pubmed publisher
    ..78; 95%CI, 0.65-0.95). In NAT2, when considering the individuals inferred acetylator phenotypes based on their NAT2 diplotype, "slow" ..
  43. Lee S, Chung L, Huang H, Chuang T, Liou Y, Wu L. NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis. Int J Tuberc Lung Dis. 2010;14:622-6 pubmed
    ..To evaluate whether the polymorphisms of the cytochrome P450 2EI (CYP2E1) and N-acetyltransferase 2 (NAT2) gene are associated with ATDH...
  44. Li D, Jiao L, Li Y, Doll M, Hein D, Bondy M, et al. Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer. Carcinogenesis. 2006;27:103-11 pubmed
    ..e. cytochrome P450 1A2 (CYP1A2) and N-acetyltransferase 1 and 2 (NAT1 and NAT2), in a hospital-based case-control study of 365 patients with pancreatic adenocarcinoma and 379 frequency-matched ..
  45. Patin E, Barreiro L, Sabeti P, Austerlitz F, Luca F, Sajantila A, et al. Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes. Am J Hum Genet. 2006;78:423-36 pubmed
    The human N-acetyltransferase genes NAT1 and NAT2 encode two phase-II enzymes that metabolize various drugs and carcinogens. Functional variability at these genes has been associated with adverse drug reactions and cancer susceptibility...
  46. Bolt H, Selinski S, Dannappel D, Blaszkewicz M, Golka K. Re-investigation of the concordance of human NAT2 phenotypes and genotypes. Arch Toxicol. 2005;79:196-200 pubmed
    A comparative study of N-acetyltransferase 2 (NAT2) genotyping and phenotyping (caffeine test method) was performed on 211 persons to elucidate apparent discrepancies in the assignment of NAT2*12 and NAT2*13 alleles which occur in the ..
  47. Belogubova E, Kuligina E, Togo A, Karpova M, Ulibina J, Shutkin V, et al. 'Comparison of extremes' approach provides evidence against the modifying role of NAT2 polymorphism in lung cancer susceptibility. Cancer Lett. 2005;221:177-83 pubmed
    b>NAT2 (arylamine N-acetyltransferase 2) polymorphism, being a key determinant of individual variations in acetylation capacity, is suspected to modify the risk of carcinogen-related malignancies...
  48. Kinzig Schippers M, Tomalik Scharte D, Jetter A, Scheidel B, Jakob V, Rodamer M, et al. Should we use N-acetyltransferase type 2 genotyping to personalize isoniazid doses?. Antimicrob Agents Chemother. 2005;49:1733-8 pubmed
    Isoniazid is metabolized by the genetically polymorphic arylamine N-acetyltransferase type 2 (NAT2)...
  49. Chiou H, Wu M, Chien W, Cheng Y, Wong R, Chen C, et al. NAT2 fast acetylator genotype is associated with an increased risk of lung cancer among never-smoking women in Taiwan. Cancer Lett. 2005;223:93-101 pubmed
    ..The association of genetic polymorphisms of CYP1A2 and NAT2, two major enzymes responsible for the metabolism of heterocyclic amines, with lung cancer has been investigated ..
  50. van der Hel O, Bueno de Mesquita H, van Gils C, Roest M, Slothouber B, Grobbee D, et al. Cumulative genetic defects in carcinogen metabolism may increase breast cancer risk (The Netherlands). Cancer Causes Control. 2005;16:675-81 pubmed
    Variants in the metabolic genes NAT1, NAT2, GSTM1 or GSTT1, may cause differences in individual detoxifying capacity of possible carcinogens...
  51. Habalova V, Salagovic J, Kalina I, Stubna J. A pilot study testing the genetic polymorphism of N-acetyltransferase 2 as a risk factor in lung cancer. Neoplasma. 2005;52:364-8 pubmed
    b>NAT2 as phase II enzyme is involved in the detoxification/activation of various drugs, environmental substances and carcinogenic compounds...
  52. Borlak J, Reamon Buettner S. N-acetyltransferase 2 (NAT2) gene polymorphisms in Parkinson's disease. BMC Med Genet. 2006;7:30 pubmed
    ..Sequence variations in N-acetyltransferase 2 (NAT2) gene leading to slow acetylation process have been associated with PD, but results are contradictory...
  53. Vuilleumier N, Rossier M, Chiappe A, Degoumois F, Dayer P, Mermillod B, et al. CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis. Eur J Clin Pharmacol. 2006;62:423-9 pubmed
    To determine whether pharmacogenetic tests such as N-acetyltransferase 2 (NAT2) and cytochrome P450 2E1 (CYP2E1) genotyping are useful in identifying patients prone to antituberculosis drug-induced hepatotoxicity in a cosmopolite ..
  54. Jain M, Kumar S, Lal P, Tiwari A, Ghoshal U, Mittal B. Association of genetic polymorphisms of N-acetyltransferase 2 and susceptibility to esophageal cancer in north Indian population. Cancer Invest. 2007;25:340-6 pubmed
    ..Tobacco smoke and alcohol are strong environmental risk factors. N-acetyltransferase 2 (NAT2) is known to metabolize heterocyclic amine carcinogens in tobacco smoke...
  55. Hein D. N-acetyltransferase SNPs: emerging concepts serve as a paradigm for understanding complexities of personalized medicine. Expert Opin Drug Metab Toxicol. 2009;5:353-66 pubmed
    ..As medical care moves to a more personalized approach, the implications of these confounding factors will be important in understanding the complexities of personalized medicine. ..
  56. Zhong X, Hui C, Xiao Ling W, Yan L, Na L. NAT2 polymorphism and gastric cancer susceptibility: a meta-analysis. Arch Med Res. 2010;41:275-80 pubmed publisher
    N-acetyltransferase 2 (NAT2) is a polymorphic enzyme that plays an important role in the metabolism of various potential carcinogens. NAT2 can be subdivided into rapid and slow acetylation phenotype according to the different genotypes...
  57. García Closas M, Hein D, Silverman D, Malats N, Yeager M, Jacobs K, et al. A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background. Pharmacogenet Genomics. 2011;21:231-6 pubmed publisher
    The arylamine N-acetyltransferase 2 (NAT2) slow acetylation phenotype is an established risk factor for urinary bladder cancer...
  58. Mortensen H, Froment A, Lema G, Bodo J, Ibrahim M, Nyambo T, et al. Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populations. Pharmacogenomics. 2011;12:1545-58 pubmed publisher
    ..We have characterized nucleotide variation at the NAT1 and NAT2 genes, and at the NATP1 pseudogene in global human populations, including many previously under-represented African ..
  59. Ruiz J, Martínez C, Anderson K, Gross M, Lang N, García Martín E, et al. The differential effect of NAT2 variant alleles permits refinement in phenotype inference and identifies a very slow acetylation genotype. PLoS ONE. 2012;7:e44629 pubmed publisher
    ..suggest that acetylation phenotype categories are heterogeneous and that subcategories, related to specific NAT2 variant alleles might exist...
  60. Cooper G, Treadwell E, Dooley M, St Clair E, Gilkeson G, Taylor J. N-acetyl transferase genotypes in relation to risk of developing systemic lupus erythematosus. J Rheumatol. 2004;31:76-80 pubmed
    To examine the association between N-acetyl transferase (NAT) genotype (NAT1 and NAT2) and risk of developing systemic lupus erythematosus (SLE)...
  61. Chan A, Tranah G, Giovannucci E, Willett W, Hunter D, Fuchs C. Prospective study of N-acetyltransferase-2 genotypes, meat intake, smoking and risk of colorectal cancer. Int J Cancer. 2005;115:648-52 pubmed
    ..N-acetyltransferase 2 (NAT2) appears to activate carcinogenic heterocyclic amines found in meat as well as cigarette smoke...
  62. Kiss I, Németh A, Bogner B, Pajkos G, Orsos Z, Sandor J, et al. Polymorphisms of glutathione-S-transferase and arylamine N-acetyltransferase enzymes and susceptibility to colorectal cancer. Anticancer Res. 2004;24:3965-70 pubmed
    ..We evaluated the effect of GSTM1, GSTT1, GSTP1, NAT1 and NAT2 enzymes on individual susceptibility to colorectal cancer, with particular attention to possible interactions ..
  63. Skuladottir H, Autrup H, Autrup J, Tjoenneland A, Overvad K, Ryberg D, et al. Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway. Lung Cancer. 2005;48:187-99 pubmed
    ..and polymorphisms in following genotypes were determined GSTM1, GSTM3, GSTP1, GSTT1, GPX1, MPO, NQO1 and NAT2. Based on the literature, the alleles of the genotypes were categorised as high- or low-risk alleles...
  64. Garcia Closas M, Malats N, Silverman D, Dosemeci M, Kogevinas M, Hein D, et al. NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses. Lancet. 2005;366:649-59 pubmed
    ..An exception could be the association between NAT2 slow acetylation, GSTM1 null genotype, and bladder-cancer risk...
  65. Mahid S, Colliver D, Crawford N, Martini B, Doll M, Hein D, et al. Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma. BMC Med Genet. 2007;8:28 pubmed
    N-acetyltransferase 1 (NAT1) and 2 (NAT2) are polymorphic isoenzymes responsible for the metabolism of numerous drugs and carcinogens...
  66. Shin A, Shrubsole M, Rice J, Cai Q, Doll M, Long J, et al. Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk. Cancer Epidemiol Biomarkers Prev. 2008;17:320-9 pubmed publisher
    ..involved in heterocyclic amine (HCA) metabolism, including N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2), cytochrome P450 1A2 (CYP1A2), and aryl hydrocarbon receptor (AhR)...
  67. Possuelo L, Castelan J, de Brito T, Ribeiro A, Cafrune P, Picon P, et al. Association of slow N-acetyltransferase 2 profile and anti-TB drug-induced hepatotoxicity in patients from Southern Brazil. Eur J Clin Pharmacol. 2008;64:673-81 pubmed publisher
    To determine the frequency of N-acetyltransferase 2 (NAT2) polymorphisms, the NAT2 acetylation profile and its relation to the incidence of gastrointestinal adverse drug reactions (ADRs), anti-tuberculosis (TB) drug-induced hepatotoxicity,..
  68. Cotterchio M, Boucher B, Manno M, Gallinger S, Okey A, Harper P. Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2008;17:3098-107 pubmed publisher
    ..CYP2C9 and NAT2 variants were associated with colorectal cancer risk...
  69. Matimba A, Del Favero J, Van Broeckhoven C, Masimirembwa C. Novel variants of major drug-metabolising enzyme genes in diverse African populations and their predicted functional effects. Hum Genomics. 2009;3:169-90 pubmed
    ..The aim of the present study was to search for novel variants of CYP2C9 , CYP2C19 , CYP2D6 and NAT2 genes in Africans, with a particular focus on their prevalence in different populations, their relevance to enzyme ..
  70. Yamada S, Tang M, Richardson K, Halaschek Wiener J, Chan M, Cook V, et al. Genetic variations of NAT2 and CYP2E1 and isoniazid hepatotoxicity in a diverse population. Pharmacogenomics. 2009;10:1433-45 pubmed publisher
    ..This pilot study investigated the effects of genetic variation in NAT2 and CYP2E1 on isoniazid-induced hepatotoxicity in TB contacts in British Columbia, Canada...
  71. Kim S, Kim S, Bahn J, Kim Y, Chang Y, Shin E, et al. Genetic polymorphisms of drug-metabolizing enzymes and anti-TB drug-induced hepatitis. Pharmacogenomics. 2009;10:1767-79 pubmed publisher
    ..SNPs in promoter, exons and haplotypes in seven drug-metabolizing enzyme genes (CYP2C9, CYP2C19, CYP2D6, CYP2E1, NAT2, UGT1A1 and UGT1A3) between 67 cases and 159 controls...
  72. Teixeira R, Silva F, Silveira A, Cabello P, Mendonça Lima L, Rabahi M, et al. Sequence analysis of NAT2 gene in Brazilians: identification of undescribed single nucleotide polymorphisms and molecular modeling of the N-acetyltransferase 2 protein structure. Mutat Res. 2010;683:43-9 pubmed publisher
    N-Acetyltransferase 2 (NAT2) metabolizes a variety of xenobiotics that includes many drugs, chemicals and carcinogens...
  73. Mikuls T, LEVAN T, Gould K, Yu F, Thiele G, Bynote K, et al. Impact of interactions of cigarette smoking with NAT2 polymorphisms on rheumatoid arthritis risk in African Americans. Arthritis Rheum. 2012;64:655-64 pubmed publisher
    ..GSTM1-null) in addition to tagging single-nucleotide polymorphisms (SNPs) in N-acetyltransferase 1 (NAT1), NAT2, and epoxide hydrolase 1 (EPXH1)...
  74. Kumagai S, Komada F, Kita T, Morinobu A, Ozaki S, Ishida H, et al. N-acetyltransferase 2 genotype-related efficacy of sulfasalazine in patients with rheumatoid arthritis. Pharm Res. 2004;21:324-9 pubmed
    ..optimization of drug therapy with sulfasalazine (SASP), we studied the influence of the N-acetyltransferase 2 (NAT2) genotype on the pharmacokinetics, efficacy, and incidence of adverse reactions of SASP in patients...
  75. Bu R, Gutierrez M, al Rasheed M, Belgaumi A, Bhatia K. Variable drug metabolism genes in Arab population. Pharmacogenomics J. 2004;4:260-6 pubmed
    ..We used PCR analysis to catalog the frequencies of alleles and genotypes for CYP1A1, NAT2, GSTs, MTHFR, MTR (MS) and NQO*1 in Arabs...
  76. Hung R, Boffetta P, Brennan P, Malaveille C, Hautefeuille A, Donato F, et al. GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk population. Int J Cancer. 2004;110:598-604 pubmed
    ..Two N-acetyltransferase isozymes, NAT2 and NAT1, have major roles in catalyzing the N-acetylation and O-acetylation of aromatic amines...
  77. Johnson N, Bell P, Jonovska V, Budge M, Sim E. NAT gene polymorphisms and susceptibility to Alzheimer's disease: identification of a novel NAT1 allelic variant. BMC Med Genet. 2004;5:6 pubmed
    ..with and without Alzheimer's disease were genotyped at the polymorphic NAT1 (147 cases; 111 controls) and NAT2 (45 cases; 63 controls) loci by polymerase chain reaction-restriction fragment length polymorphism, and the ..
  78. Sabbagh A, Darlu P. SNP selection at the NAT2 locus for an accurate prediction of the acetylation phenotype. Genet Med. 2006;8:76-85 pubmed
    ..However, due to extensive linkage disequilibrium between markers within NAT2, the genotyping of closely spaced markers yields highly redundant data: testing them all is expensive and often ..
  79. Teixeira R, Miranda A, Pacheco A, Lopes M, Fonseca Costa J, Rabahi M, et al. Genetic profile of the arylamine N-acetyltransferase 2 coding gene among individuals from two different regions of Brazil. Mutat Res. 2007;624:31-40 pubmed
    ..intermediates and the degree of hepatotoxicity severity has been attributed to genetic variability in the NAT2 gene...
  80. Wu H, Dombrovsky L, Tempel W, Martin F, Loppnau P, Goodfellow G, et al. Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases. J Biol Chem. 2007;282:30189-97 pubmed
    The human arylamine N-acetyltransferases NAT1 and NAT2 play an important role in the biotransformation of a plethora of aromatic amine and hydrazine drugs...
  81. Murta Nascimento C, Silverman D, Kogevinas M, Garcia Closas M, Rothman N, Tardon A, et al. Risk of bladder cancer associated with family history of cancer: do low-penetrance polymorphisms account for the increase in risk?. Cancer Epidemiol Biomarkers Prev. 2007;16:1595-600 pubmed
    ..The OR of bladder cancer for those reporting family history of bladder cancer was 4.76 (95% CI, 1.25-18.09) among NAT2-slow acetylators and 1.17 (95% CI, 0.17-7.86) among NAT2-rapid/intermediate acetylators (P(interaction) = 0.609)...
  82. Soejima M, Kawaguchi Y, Hara M, Kamatani N. Prospective study of the association between NAT2 gene haplotypes and severe adverse events with sulfasalazine therapy in patients with rheumatoid arthritis. J Rheumatol. 2008;35:724 pubmed
  83. Zupa A, Sgambato A, Bianchino G, Improta G, Grieco V, La Torre G, et al. GSTM1 and NAT2 polymorphisms and colon, lung and bladder cancer risk: a case-control study. Anticancer Res. 2009;29:1709-14 pubmed
    Glutathione S-transferase M1 (GSTM1) and N-acetyltransferase-2 (NAT2) are phase II enzymes involved in the metabolism of xenobiotics and whose polymorphisms have been related to individual cancer risks...
  84. Gong C, Hu X, Gao Y, Cao Y, Gao F, Mo Z. A meta-analysis of the NAT1 and NAT2 polymorphisms and prostate cancer: a huge review. Med Oncol. 2011;28:365-76 pubmed publisher
    Studies revealing conflicting results on the role of NAT1 or NAT2 phenotypes on prostate cancer risk led us to perform a meta-analysis to investigate the association of these polymorphisms and prostate cancer risk...
  85. Loktionov A, Moore W, Spencer S, Vorster H, Nell T, O Neill I, et al. Differences in N-acetylation genotypes between Caucasians and Black South Africans: implications for cancer prevention. Cancer Detect Prev. 2002;26:15-22 pubmed
    Polymorphic N-acetyltransferase genes (NAT1 and NAT2) determine rapid or slow acetylation phenotypes, which are believed to affect cancer risk related to environmental exposure...
  86. Tiemersma E, Voskuil D, Bunschoten A, Hogendoorn E, Witteman B, Nagengast F, et al. Risk of colorectal adenomas in relation to meat consumption, meat preparation, and genetic susceptibility in a Dutch population. Cancer Causes Control. 2004;15:225-36 pubmed
    ..8 and 0.9, respectively). Only the combination of NAT2 slow acetylation and frequent meat consumption (> 5x/week) slightly increased adenoma risk (OR 1.6, 95% CI 1.1-2...
  87. Sillanpää P, Hirvonen A, Kataja V, Eskelinen M, Kosma V, Uusitupa M, et al. NAT2 slow acetylator genotype as an important modifier of breast cancer risk. Int J Cancer. 2005;114:579-84 pubmed
    N-acetyltransferase 2 (NAT2) is a polymorphic enzyme participating in the metabolism of numerous pharmaceutical drugs and carcinogens found in tobacco smoke and diet...
  88. Chiu B, Kolar C, Gapstur S, Lawson T, Anderson J, Weisenburger D. Association of NAT and GST polymorphisms with non-Hodgkin's lymphoma: a population-based case-control study. Br J Haematol. 2005;128:610-5 pubmed
    ..4; 95% confidence interval (CI) = 0.9-2.3], but not in men. NAT2 slow genotype was not associated with risk in either sex...
  89. Sørensen M, Autrup H, Tjønneland A, Overvad K, Raaschou Nielsen O. Genetic polymorphisms in CYP1B1, GSTA1, NQO1 and NAT2 and the risk of lung cancer. Cancer Lett. 2005;221:185-90 pubmed
    ..and in the phase II genes glutathione S-transferase A1, NAD(P)H quinone oxidoreductase and N-acetyltransferase 2 (NAT2)...
  90. Chaudhary S, Behari M, Dihana M, Swaminath P, Govindappa S, Jayaram S, et al. Association of N-acetyl transferase 2 gene polymorphism and slow acetylator phenotype with young onset and late onset Parkinson's disease among Indians. Pharmacogenet Genomics. 2005;15:731-5 pubmed
    ..age at onset >40 years) and 324 age and sex matched controls (132 for YOPD and 192 for LOPD) were genotyped for NAT2 SNPs. Allelic, genotypic and haplotypic association was tested by chi2 using a case-control approach...
  91. Lilla C, Verla Tebit E, Risch A, Jäger B, Hoffmeister M, Brenner H, et al. Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption. Cancer Epidemiol Biomarkers Prev. 2006;15:99-107 pubmed
    N-Acetyltransferases 1 and 2 (NAT1 and NAT2), both being highly polymorphic, are involved in the metabolism of aromatic and heterocyclic aromatic amines present in cigarette smoke and red meat cooked by high-temperature cooking techniques...
  92. Husain A, Zhang X, Doll M, States J, Barker D, Hein D. Identification of N-acetyltransferase 2 (NAT2) transcription start sites and quantitation of NAT2-specific mRNA in human tissues. Drug Metab Dispos. 2007;35:721-7 pubmed
    Human N-acetyltransferase 2 (NAT2) genetic polymorphism is associated with drug toxicity and/or carcinogenesis in various tissues. Knowledge of NAT2 gene structure and expression is critical for understanding these associations...