NAPSA

Summary

Gene Symbol: NAPSA
Description: napsin A aspartic peptidase
Alias: KAP, Kdap, NAP1, NAPA, SNAPA, napsin-A, ASP4, TA01/TA02, asp 4, aspartyl protease 4, kidney-derived aspartic protease-like protein, napsin-1, pronapsin A
Species: human
Products:     NAPSA

Top Publications

  1. Chuman Y, Bergman A, Ueno T, Saito S, Sakaguchi K, Alaiya A, et al. Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas. FEBS Lett. 1999;462:129-34 pubmed
    ..The site of processing of pronapsin A to the mature form was located...
  2. Ueno T, Elmberger G, Weaver T, Toi M, Linder S. The aspartic protease napsin A suppresses tumor growth independent of its catalytic activity. Lab Invest. 2008;88:256-63 pubmed publisher
    Members of the aspartic protease family have been implicated in cancer progression. The aspartic protease napsin A is expressed in type II cells of the lung, where it is involved in the processing of surfactant protein B (SP-B)...
  3. Bishop J, Sharma R, Illei P. Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma. Hum Pathol. 2010;41:20-5 pubmed publisher
    ..b>Napsin A is an aspartic proteinase involved in the maturation of surfactant protein B...
  4. Tatnell P, Powell D, Hill J, Smith T, Tew D, Kay J. Napsins: new human aspartic proteinases. Distinction between two closely related genes. FEBS Lett. 1998;441:43-8 pubmed
    ..The (pro)napsin A gene is expressed predominantly in lung and kidney and its translation product is predicted to be a fully ..
  5. Schauer Vukasinovic V, Bur D, Kling D, Grüninger F, Giller T. Human napsin A: expression, immunochemical detection, and tissue localization. FEBS Lett. 1999;462:135-9 pubmed
    ..Due to high similarity with cathepsin D a structural model of human napsin A could be built...
  6. Ordonez N. Napsin A expression in lung and kidney neoplasia: a review and update. Adv Anat Pathol. 2012;19:66-73 pubmed publisher
    b>Napsin A is an aspartic protease present in the epithelial cells of the lung and kidney...
  7. Ordonez N. A word of caution regarding napsin A expression in squamous cell carcinomas of the lung. Am J Surg Pathol. 2012;36:396-401 pubmed publisher
    b>Napsin A is a novel peripheral airway epithelial marker that, because it is commonly expressed in lung adenocarcinomas but absent in squamous cell carcinomas, is considered to be useful in distinguishing between these 2 types of tumors...
  8. Turner B, Cagle P, Sainz I, Fukuoka J, Shen S, Jagirdar J. Napsin A, a new marker for lung adenocarcinoma, is complementary and more sensitive and specific than thyroid transcription factor 1 in the differential diagnosis of primary pulmonary carcinoma: evaluation of 1674 cases by tissue microarray. Arch Pathol Lab Med. 2012;136:163-71 pubmed publisher
    ..TTF-1 is a favored marker for lung ACA but has limited sensitivity and specificity. Napsin A (Nap-A) is a functional aspartic proteinase that may be an alternative marker for primary lung ACA...
  9. Khanafer N, Barbut F, Eckert C, Perraud M, Demont C, Luxemburger C, et al. Factors predictive of severe Clostridium difficile infection depend on the definition used. Anaerobe. 2016;37:43-8 pubmed publisher
    ..Over the past decade, the emergence of the BI/NAP1/027 strain has been linked to higher prevalence and severity of CDI...

More Information

Publications136 found, 100 shown here

  1. Song Z, Zhao Q, Zhu L, Zhang Z, Jiang L, Huang H. Draft genome sequence of multidrug-resistant β-lactamase-producing Bacillus cereus S66 isolated from China. J Glob Antimicrob Resist. 2019;17:23-24 pubmed publisher
    ..496, some of which are associated with gastrointestinal infection, eye infection and neutrophil-activating protein NapA. Antimicrobial resistance-related genes comprised 3...
  2. Lee E, Jung S, Lee S, Lee N, Paik H, Lim S. Lactobacillus plantarum Strain Ln4 Attenuates Diet-Induced Obesity, Insulin Resistance, and Changes in Hepatic mRNA Levels Associated with Glucose and Lipid Metabolism. Nutrients. 2018;10: pubmed publisher
    ..Of the strains tested, Lactobacillus plantarum Ln4 (Ln4), which was obtained from napa cabbage kimchi, significantly reduced lipid accumulation and stimulated glucose uptake in 3T3-L1 adipocytes...
  3. Fennell D, Myrand S, Nguyen T, Ferry D, Kerr K, Maxwell P, et al. Association between gene expression profiles and clinical outcome of pemetrexed-based treatment in patients with advanced non-squamous non-small cell lung cancer: exploratory results from a phase II study. PLoS ONE. 2014;9:e107455 pubmed publisher
    ..01, genes: Chromosome 16 open reading frame 89, napsin A, surfactant protein B, aquaporin 4, TRAF2- and Nck-interacting kinase, Lysophosphatidylcholine acyltransferase 1, ..
  4. Erismann S, Knoblauch A, Diagbouga S, Odermatt P, Gerold J, Shrestha A, et al. Prevalence and risk factors of undernutrition among schoolchildren in the Plateau Central and Centre-Ouest regions of Burkina Faso. Infect Dis Poverty. 2017;6:17 pubmed publisher
    ..to children to determine their knowledge of nutrition and health and their related attitudes and practices (KAP)...
  5. Štrkolcová G, Goldová M, Bocková E, Mojžišová J. The roundworm Strongyloides stercoralis in children, dogs, and soil inside and outside a segregated settlement in Eastern Slovakia: frequent but hardly detectable parasite. Parasitol Res. 2017;116:891-900 pubmed publisher
    ..Applying the Koga agar plate (KAP) culture method and microscopy examination of stool samples collected from 60 Roma and 21 nonRoma children, no ..
  6. Zheng H, Kim J, Liew M, Yan J, Herrera O, Bok J, et al. Redox metabolites signal polymicrobial biofilm development via the NapA oxidative stress cascade in Aspergillus. Curr Biol. 2015;25:29-37 pubmed publisher
    ..Phenazine conidiation signaling was conserved in the genetic model A. nidulans and mediated by NapA, a homolog of AP-1-like bZIP transcription factor, which is essential for the response to oxidative stress in ..
  7. Jassim S, Khiyami A, Nguyen J, Ganesan S, Tomashefski J, Sawady J. Concordant clear cell "mesonephric" carcinoma of the bladder and lung adenocarcinoma with clear cell features - multiple primaries versus metastatic neoplasms: a case report. J Med Case Rep. 2017;11:133 pubmed publisher
    ..The neoplastic cells were diffusely positive for cytokeratin 7, napsin A, and thyroid transcription factor 1, and they were negative for cytokeratin 20 and cancer antigen 125...
  8. Piljić Burazer M, Mladinov S, Capkun V, Kuret S, Glavina Durdov M. The Utility of Thyroid Transcription Factor 1 (TTF-1), Napsin A, Excision Repair Cross-Complementing 1 (ERCC1), Anaplastic Lymphoma Kinase (ALK) and the Epidermal Growth Factor Receptor (EGFR) Expression in Small Biopsy in Prognosis of Patients with . Med Sci Monit. 2017;23:489-497 pubmed
    ..were retrospectively investigated in small biopsies for the immunohistochemical expression of TTF-1, napsin A, ERCC1, ALK, and the EGFR mutation by real-time polymerase chain reaction (rtPCR)...
  9. Mauti S, Traoré A, Hattendorf J, Schelling E, Wasniewski M, Schereffer J, et al. Factors associated with dog rabies immunisation status in Bamako, Mali. Acta Trop. 2017;165:194-202 pubmed publisher
    ..seroprevalence of rabies virus antibodies in the dog population and people's knowledge, attitudes and practices (KAP) towards the disease and its control...
  10. Saleh Faidah H, Haseeb A, Yousuf Lamfon M, Mohammad Almatrafi M, Abdullah Almasoudi I, Cheema E, et al. Parents' self-directed practices towards the use of antibiotics for upper respiratory tract infections in Makkah, Saudi Arabia. BMC Pediatr. 2019;19:46 pubmed publisher
    ..We have conducted Knowledge, Attitude and Perception (KAP) survey of parents to explore the parent's knowledge, attitude & perception of Saudi parents...
  11. Salisbury P, Hall L, Kulkus S, Paw M, Tun N, Min A, et al. Family planning knowledge, attitudes and practices in refugee and migrant pregnant and post-partum women on the Thailand-Myanmar border - a mixed methods study. Reprod Health. 2016;13:94 pubmed publisher
    Lack of data in marginalized populations on knowledge, attitudes and practices (KAP) hampers efforts to improve modern contraceptive practice...
  12. Reichel A, Stilp A, Scherer M, Reuter N, Lukassen S, Kasmapour B, et al. Chromatin-Remodeling Factor SPOC1 Acts as a Cellular Restriction Factor against Human Cytomegalovirus by Repressing the Major Immediate Early Promoter. J Virol. 2018;92: pubmed publisher
    ..It binds H3K4me2/3-containing chromatin and promotes DNA condensation by recruiting corepressors such as KAP-1 and H3K9 methyltransferases...
  13. Zheng B, Wang P, Xue L, Liu X, Guo L, Ying J. [Combination of environmental friendly reagent and ultrasonic assisted rapid processing for protein and molecular detection in tumor biopsy specimens]. Zhonghua Bing Li Xue Za Zhi. 2019;48:116-119 pubmed publisher
    ..1组、实验2组的共计43例全自动免疫组织化学检测HER2、Napsin A、甲状腺转录因子(TTF)1、MLH1的细胞核、胞质、胞膜染色结果,4例HER2荧光原位杂交(..
  14. Herghelegiu C, Neacsu A, Oprescu N, Cărbunaru A, Brăila A, Curea F, et al. Difficulties of clinical and histopathological diagnosis in advanced vulvar clear cell carcinoma. Rom J Morphol Embryol. 2018;59:1233-1237 pubmed
    ..Microscopic examination revealed CCC. The tumor was positive for cytokeratin 7 (CK7), paired-box 8 (Pax8), napsin A and vimentin, negative for estrogen receptor (ER), progesterone receptor (PR), calretinin, cluster of ..
  15. Mainali S, Lamichhane R, Clark K, Beatty S, Fatouros M, Neville P, et al. "Looking over the Backyard Fence": Householders and Mosquito Control. Int J Environ Res Public Health. 2017;14: pubmed publisher
    ..were randomly surveyed during the summer of 2015-2016, to gauge residents' knowledge, attitudes, and practices (KAP (knowledge, attitudes, and practices) Survey) in regards to mosquitoes, their breeding and ecology, and avoidance ..
  16. Bok J, Wiemann P, Garvey G, Lim F, Haas B, Wortman J, et al. Illumina identification of RsrA, a conserved C2H2 transcription factor coordinating the NapA mediated oxidative stress signaling pathway in Aspergillus. BMC Genomics. 2014;15:1011 pubmed publisher
    ..in global up-regulation of several components of the oxidative stress metabolome including the expression of napA and atfA, the two bZIP transcription factors mediating resistance to reactive oxygen species (ROS) as well as NapA ..
  17. Naderi S, Ghorra C, Haddad F, Kourie H, Rassy M, El Karak F, et al. EGFR mutation status in Middle Eastern patients with non-squamous non-small cell lung carcinoma: A single institution experience. Cancer Epidemiol. 2015;39:1099-102 pubmed publisher
    ..characteristics (age, gender, smoking status, stage), the samples' characteristics (histology subtype, TTF-1 and Napsin A immunostainings, the site and the adequacy and the type of the sample), and the mutational EGFR status (presence ..
  18. Shu C, Fu A, Lu J, Yin M, Chen Y, Qin T, et al. Association between age at first sexual intercourse and knowledge, attitudes and practices regarding reproductive health and unplanned pregnancy: a cross-sectional study. Public Health. 2016;135:104-13 pubmed publisher
    ..students first engage in sexual activity, and the association between AFSI and knowledge, attitudes and practices (KAP) regarding reproductive health and unplanned pregnancy...
  19. Tian J, Glenn G, FLYER D, Zhou B, Liu Y, Sullivan E, et al. Clostridium difficile chimeric toxin receptor binding domain vaccine induced protection against different strains in active and passive challenge models. Vaccine. 2017;35:4079-4087 pubmed publisher
    ..Over the past decade, however, highly virulent epidemic strains of C. difficile (B1/NAP1/027) have emerged and are linked to an increase in morbidity and mortality...
  20. Riccò M, Vezzosi L, Gualerzi G, Balzarini F, Capozzi V, Volpi L. Knowledge, attitudes, beliefs and practices of obstetrics-gynecologists on seasonal influenza and pertussis immunizations in pregnant women: preliminary results from North-Western Italy. Minerva Ginecol. 2019;: pubmed publisher
    ..In this cross sectional study, we documented specific knowledge, attitudes, and practices (KAP) in a sample of obstetrician-gynecologists (OBGYN). A total of 68 OBGYN (39.7% of males, mean age of 47.7 ± 9...
  21. Ayele Y, Gutema F, Edao B, Girma R, Tufa T, Beyene T, et al. Assessment of Staphylococcus aureus along milk value chain and its public health importance in Sebeta, central Oromia, Ethiopia. BMC Microbiol. 2017;17:141 pubmed publisher
    ..aureus and knowledge, attitudes and practices (KAP) of actors along the milk value chain in Sebeta, Central Oromia, Ethiopia...
  22. Wang G, Maier R. A novel DNA-binding protein plays an important role in Helicobacter pylori stress tolerance and survival in the host. J Bacteriol. 2015;197:973-82 pubmed publisher
    ..oxidative stress conditions revealed a number of important antioxidant protein differences; SodB, Tpx, TrxR, and NapA, as well as the peptidoglycan deacetylase PgdA, were significantly less expressed in the Δhp119 mutant than in ..
  23. Datta C, Jha R, Ganguly S, Nagaraja V. NapA (Rv0430), a novel nucleoid-associated protein that regulates a virulence operon in Mycobacterium tuberculosis in a supercoiling-dependent manner. J Mol Biol. 2019;: pubmed publisher
    ..The sensitivity of rv0430 expression to supercoiling is consistent with supercoiling being important for infection by M. tuberculosis. Thus, Rv0430 is a novel NAP, doubling up as a topology modulator of M. tuberculosis. ..
  24. Erismann S, Shrestha A, Diagbouga S, Knoblauch A, Gerold J, Herz R, et al. Complementary school garden, nutrition, water, sanitation and hygiene interventions to improve children's nutrition and health status in Burkina Faso and Nepal: a study protocol. BMC Public Health. 2016;16:244 pubmed publisher
    ..A questionnaire survey on nutritional and health knowledge, attitudes and practices (KAP) will be administered to children and their caregivers, also assessing socioeconomic, food-security and WASH ..
  25. Akkawi M, Qaddumi J, Issa H, Yaseen L. Awareness of retinopathy of prematurity among pediatricians in West Bank, Palestine: a descriptive study. BMC Ophthalmol. 2018;18:195 pubmed publisher
    ..A questionnaire was designed on the knowledge, attitude, and practice (KAP) pattern...
  26. Mraihi Z, Ben Amar J, Bouacha H, Rammeh S, Hila L. EGFR mutation status in Tunisian non-small-cell lung cancer patients evaluated by mutation-specific immunohistochemistry. BMC Pulm Med. 2018;18:132 pubmed publisher
    ..Among our patients (48 men and 2 women) all adenocarcinoma (confirmed by histology and IHC with TTF1/Napsin A), 94% were smokers exceeding the tobacco risk threshold (at least 25 pack-years) and the women were none...
  27. Elyana F, Al Mekhlafi H, Ithoi I, Abdulsalam A, Dawaki S, Nasr N, et al. A tale of two communities: intestinal polyparasitism among Orang Asli and Malay communities in rural Terengganu, Malaysia. Parasit Vectors. 2016;9:398 pubmed publisher
    ..key factors associated with intestinal polyparasitism as well as to evaluate the knowledge, attitude and practices (KAP) on IPIs among rural Orang Asli and Malay communities in Terengganu, Malaysia...
  28. Parra Herran C, Lerner Ellis J, Xu B, Khalouei S, Bassiouny D, Cesari M, et al. Molecular-based classification algorithm for endometrial carcinoma categorizes ovarian endometrioid carcinoma into prognostically significant groups. Mod Pathol. 2017;30:1748-1759 pubmed publisher
    ..In the era of personalized medicine, the use of these markers in the routine evaluation of ovarian endometrioid tumors should be considered...
  29. Meshram C, Agback P, Shiliaev N, Urakova N, Mobley J, Agback T, et al. Multiple Host Factors Interact with the Hypervariable Domain of Chikungunya Virus nsP3 and Determine Viral Replication in Cell-Specific Mode. J Virol. 2018;92: pubmed publisher
    ..These host factors include two members of the G3BP family and their mosquito homolog Rin, two members of the NAP1 family, and several SH3 domain-containing proteins...
  30. Fountain E, Moses M, Park L, Woods C, Arepally G. Thrombocytopenia in hospitalized patients with severe clostridium difficile infection. J Thromb Thrombolysis. 2017;43:38-42 pubmed publisher
    ..community), NAP1/027 strain, and disease severity has not been examined...
  31. Ijaz F, Hatanaka Y, Hatanaka T, Tsutsumi K, Iwaki T, Umemura K, et al. Proper cytoskeletal architecture beneath the plasma membrane of red blood cells requires Ttll4. Mol Biol Cell. 2017;28:535-544 pubmed publisher
    ..Immunoprecipitation using the anti-glutamylation antibody GT335 revealed nucleosome assembly protein 1 (NAP1) to be the sole target of TTLL4 in the RBCs, and NAP1 glutamylation was completely lost in Ttll4-knockout ..
  32. Onishi M, Pringle J, Cross F. Evidence That an Unconventional Actin Can Provide Essential F-Actin Function and That a Surveillance System Monitors F-Actin Integrity in Chlamydomonas. Genetics. 2016;202:977-96 pubmed publisher
    ..A highly divergent actin gene, NAP1, is upregulated in ida5-1 cells, but it has been unclear whether NAP1 can form filaments or provide actin function...
  33. Mangiarotti M, D Ercole L, Quaretti P, Moramarco L, Lafe E, Zappoli Thyrion F. EVALUATION OF AN ACTIVE PERSONAL DOSIMETRY SYSTEM IN INTERVENTIONAL RADIOLOGY AND NEURORADIOLOGY: PRELIMINARY RESULTS. Radiat Prot Dosimetry. 2016;172:483-487 pubmed publisher
    ..The correlation between kerma air product (KAP) and reference point air kerma (Kar) and operator dose as a function of position with respect to the ..
  34. Ubeda C, Vano E, Miranda P, Aguirre D, Riquelme N, Dalmazzo D, et al. Patient and staff doses in paediatric interventional cardiology derived from experimental measurements with phantoms. Phys Med. 2016;32:176-81 pubmed publisher
    The aim of this paper was to determine experimentally the entrance surface air kerma (ESAK) and kerma-area product (KAP) levels to patients and scatter doses at the cardiologist's eyes during paediatric interventional cardiology (IC) ..
  35. Almansour M, Sami W, Al Rashedy O, Alsaab R, Alfayez A, Almarri N. Knowledge, attitude, and practice (KAP) of food hygiene among schools students' in Majmaah city, Saudi Arabia. J Pak Med Assoc. 2016;66:442-6 pubmed
    ..001). No significant difference was observed between groups with regard to practice levels (p=0.152). The students exhibited good practice levels, despite fair knowledge and attitude levels. ..
  36. Miao Y, Bhushan J, Dani A, Vig M. Na+ influx via Orai1 inhibits intracellular ATP-induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation. elife. 2017;6: pubmed publisher
    ..Here we show that α-SNAP hypomorph, hydrocephalus with hopping gait, Napahyh/hyh mice harbor significant defects in CD4 T cell gene expression and Foxp3 regulatory T cell (..
  37. Koo H, Lee C, Nur Hidayah A, Nurain Hazwani A. Knowledge, attitudes and practices of schoolchildren toward whole grains and nutritional outcomes in Malaysia. Appetite. 2018;123:256-263 pubmed publisher
    ..on body mass index for age z-score (BAZ) due to insufficient understanding of knowledge, attitudes and practices (KAP) toward whole grains...
  38. Alcalá Hernández L, Mena Ribas A, Niubó Bosh J, Marín Arriaza M. [Laboratory diagnosis of Clostridium difficile infection]. Enferm Infecc Microbiol Clin. 2016;34:595-602 pubmed publisher
    ..The eruption of the hypervirulent strain BI/NAP1/027 has given rise to an increase in the morbidity and mortality of C.difficile infection (CDI)...
  39. Zyoud S, Abu Taha A, Araj K, Abahri I, Sawalha A, Sweileh W, et al. Parental knowledge, attitudes and practices regarding antibiotic use for acute upper respiratory tract infections in children: a cross-sectional study in Palestine. BMC Pediatr. 2015;15:176 pubmed publisher
    ..The goal of this study was to examine parents' knowledge, attitudes, and practices (KAP) about antibiotic use for children with URTIs in Palestine...
  40. Zhang M, Zhang J, Hao Y, Fan Z, Li L, Li Y, et al. Vaccination knowledge, attitude and practice among Chinese travelers who visit travel clinics in Preparation for international travel. J Travel Med. 2016;23: pubmed publisher
    ..more common in main land China, few data are available on vaccination knowledge, attitude and practice (KAP) among Chinese travelers...
  41. Stratev D, Odeyemi O, Pavlov A, Kyuchukova R, Fatehi F, Bamidele F. Food safety knowledge and hygiene practices among veterinary medicine students at Trakia University, Bulgaria. J Infect Public Health. 2017;10:778-782 pubmed publisher
    The results from the first survey on food safety knowledge, attitudes and hygiene practices (KAP) among veterinary medicine students in Bulgaria are reported in this study...
  42. Pan J, Qi S, Sun Y, Jiang Y, Zhao N, Huang L, et al. Nitrogen removal and nitrogen functional gene abundances in three subsurface wastewater infiltration systems under different modes of aeration and influent C/N ratios. Bioresour Technol. 2017;241:1162-1167 pubmed publisher
    ..and TN removal and the enrichment of nitrogen removal functional genes (amoA, nxrA, narG, napA, nirK, nirS, qnorB and nosZ) compared to NA SWIS, especially under high influent C/N ratio...
  43. Reddy D, Bhattacharya S, Jani V, Sonavane U, Joshi R, Gupta S. Biochemical and Biophysical Characterisation of Higher Oligomeric Structure of Rat Nucleosome Assembly Protein 1. Protein J. 2018;37:58-69 pubmed publisher
    Nucleosome assembly protein 1 (NAP1) is a histone chaperone that exchanges histone H2A-H2B dimer from chromatin templates. Studies with yeast NAP1 (yNAP1) have revealed its existence as multiple oligomeric species in solution...
  44. Udayanga L, Gunathilaka N, Iqbal M, Pahalagedara K, Amarasinghe U, Abeyewickreme W. Socio-economic, Knowledge Attitude Practices (KAP), household related and demographic based appearance of non-dengue infected individuals in high dengue risk areas of Kandy District, Sri Lanka. BMC Infect Dis. 2018;18:88 pubmed publisher
  45. Gholami F, Nikookheslat S, Salekzamani Y, Boule N, Jafari A. Effect of aerobic training on nerve conduction in men with type 2 diabetes and peripheral neuropathy: A randomized controlled trial. Neurophysiol Clin. 2018;48:195-202 pubmed publisher
    ..007). Changes in peroneal and tibial motor NCV and nerve action potential amplitude (NAPA) in all nerves studied were not different between groups (P>0.05)...
  46. Lin X, Han Q, Wang E, Zhang Y. Pulmonary papillary adenoma presenting in central portion: a case report. Diagn Pathol. 2015;10:190 pubmed publisher
    ..the epithelial cells were diffusely positive for cytokeratin, cytokeratin7, TTF-1, EMA, surfactant apoprotein A, Napsin A, P63 and β-catenin. The Ki-67 proliferation index was approximately 2 %...
  47. Wang S, Rustandi R, Lancaster C, Hong L, Thiriot D, Xie J, et al. Toxicity assessment of Clostridium difficile toxins in rodent models and protection of vaccination. Vaccine. 2016;34:1319-23 pubmed publisher
    ..The two major toxins, toxin A and toxin B are produced by most C. difficile bacteria, but some strains, such as BI/NAP1/027 isolates, produce a third toxin called binary toxin...
  48. Tekle Haimanot R, Preux P, Gerard D, Worku D, Belay H, Gebrewold M. Impact of an educational comic book on epilepsy-related knowledge, awareness, and attitudes among school children in Ethiopia. Epilepsy Behav. 2016;61:218-223 pubmed publisher
    ..We collected information using a structured KAP questionnaire before and after reading a comic book...
  49. Etard C, Bigand E, Salvat C, Vidal V, Beregi J, Hornbeck A, et al. Patient dose in interventional radiology: a multicentre study of the most frequent procedures in France. Eur Radiol. 2017;27:4281-4290 pubmed publisher
    ..Kerma area product (KAP), fluoroscopy time (FT), reference air kerma and number of images were recorded for 10 to 30 patients per procedure...
  50. Liu B. [Fulminant Clostridium difficile colitis: new challenges in critical care medicine]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:564-567 pubmed publisher
    ..In particular, the recently discovered mutant CD strain NAP1/BI/ribotype 027 has high pathogenicity in the global epidemic and its outbreak...
  51. Prasad R, D Arcy S, Hada A, Luger K, Bartholomew B. Coordinated Action of Nap1 and RSC in Disassembly of Tandem Nucleosomes. Mol Cell Biol. 2016;36:2262-71 pubmed publisher
    ..We found that the histone chaperone Nap1 efficiently promotes disassembly of adjacent nucleosomes with which RSC collides and not the disassembly of ..
  52. Wang M, Li L, Xie J, Sun Y, Ling G, He Z. Transdermal Adhesive Patches Loaded with Ketoprofen Evaluated by Dynamic Detection of Percutaneous Absorption. AAPS PharmSciTech. 2017;18:2141-2148 pubmed publisher
    ..Herein, we report a ketoprofen adhesive patch (KAP) and evaluate the penetration and absorption compared to MOHRUS®...
  53. Du C, Cui C, Qiu S, Shi S, Li A, Ma F. Nitrogen removal and microbial community shift in an aerobic denitrification reactor bioaugmented with a Pseudomonas strain for coal-based ethylene glycol industry wastewater treatment. Environ Sci Pollut Res Int. 2017;24:11435-11445 pubmed publisher
    ..The napA gene analysis indicated that the decrease in nitrate and nitrite removal happened when abundance of Pseudomonas was ..
  54. Irwin K, Jalloh M, Corker J, Alpha Mahmoud B, Robinson S, Li W, et al. Attitudes about vaccines to prevent Ebola virus disease in Guinea at the end of a large Ebola epidemic: Results of a national household survey. Vaccine. 2017;35:6915-6923 pubmed publisher
    ..Sierra Leone, we conducted a national household survey about Ebola-related knowledge, attitudes, and practices (KAP) and opinions about "hypothetical" Ebola vaccines...
  55. Inoue H, Matsuzaki Y, Tanaka A, Hosoi K, Ichimura K, Arasaki K, et al. γ-SNAP stimulates disassembly of endosomal SNARE complexes and regulates endocytic trafficking pathways. J Cell Sci. 2015;128:2781-94 pubmed publisher
    ..N-ethylmaleimide-sensitive factor (NSF) and its attachment protein, α-SNAP (encoded by NAPA), catalyze disassembly of the SNARE complexes in the secretory and endocytic pathways to recycle them for the next ..
  56. Campbell B, Hofstad A, Sreekanta S, Fu F, Kono T, O Rourke J, et al. Fast neutron-induced structural rearrangements at a soybean NAP1 locus result in gnarled trichomes. Theor Appl Genet. 2016;129:1725-38 pubmed publisher
    Three adjacent and distinct sequence rearrangements were identified at a NAP1 locus in a soybean mutant. Genetic dissection and validation revealed the function of this gene in soybean trichome development. A soybean (Glycine max (L...
  57. Gui M, Chen Q, Ma T, Zheng M, Ni J. Effects of heavy metals on aerobic denitrification by strain Pseudomonas stutzeri PCN-1. Appl Microbiol Biotechnol. 2017;101:1717-1727 pubmed publisher
    ..sensitivity of denitrifying gene to heavy metals was similar in order of nosZ > nirS ? cnorB > napA. This study is of significance in understanding the potential application of aerobic denitrifying bacteria in ..
  58. Noe A, Ribeiro R, Anselmo R, Maixenchs M, Sitole L, Munguambe K, et al. Knowledge, attitudes and practices regarding tuberculosis care among health workers in Southern Mozambique. BMC Pulm Med. 2017;17:2 pubmed publisher
    ..cross-sectional study was performed through the use of a specifically designed Knowledge, Attitudes and Practices (KAP) questionnaire in the district of Manhiça, a high tuberculosis and HIV burden rural area in Southern Mozambique...
  59. Yahathugoda T, Weerasooriya M, Samarawickrema W, Kimura E, Itoh M. Impact of two follow-up schemes on morbidity management and disability prevention (MMDP) programme for filarial lymphedema in Matara, Sri Lanka. Parasitol Int. 2018;67:176-183 pubmed publisher
    ..Impact was assessed using a KAP score, number of entry lesions (EL) and number of ADL episodes, limb volume, its appearance, changes in the quality ..
  60. Greffier J, Goupil J, Larbi A, Stefanovic X, Pereira F, Moliner G, et al. Assessment of patient's peak skin dose during abdominopelvic embolization using radiochromic (Gafchromic) films. Diagn Interv Imaging. 2018;99:321-329 pubmed publisher
    ..Dosimetric indicators (DIs) such as air-kerma (AK) and kerma-area-product (KAP) were collected and peak skin dose (PSD) was measured with radiochromic films...
  61. Järvinen H, Farah J, Siiskonen T, Ciraj Bjelac O, Dabin J, Carinou E, et al. Feasibility of setting up generic alert levels for maximum skin dose in fluoroscopically guided procedures. Phys Med. 2018;46:67-74 pubmed publisher
    ..Correlation of the online dose indicators (fluoroscopy time, kerma- or dose-area product (KAP or DAP) and cumulative air kerma at interventional reference point (Ka,r)) with MSD was evaluated and ..
  62. Yimer F, Animut A, Erko B, Mamo H. Past five-year trend, current prevalence and household knowledge, attitude and practice of malaria in Abeshge, south-central Ethiopia. Malar J. 2015;14:230 pubmed publisher
    ..5-year retrospective trend and current prevalence of malaria as well as community knowledge, attitude and practice (KAP) in Walga Health Centre (WHC) catchment area in Abeshge District, south-central Ethiopia...
  63. Gong H, Zhou H, Forrest R, Li S, Wang J, Dyer J, et al. Wool Keratin-Associated Protein Genes in Sheep-A Review. Genes (Basel). 2016;7: pubmed publisher
    ..The extent and nature of genetic variation in wool KAP genes and its association with fibre characteristics, provides an opportunity for the development of gene-markers ..
  64. Dawaki S, Al Mekhlafi H, Ithoi I, Ibrahim J, Atroosh W, Abdulsalam A, et al. Is Nigeria winning the battle against malaria? Prevalence, risk factors and KAP assessment among Hausa communities in Kano State. Malar J. 2016;15:351 pubmed publisher
    ..to investigate the prevalence and risk factors of malaria and to evaluate the knowledge, attitudes, and practices (KAP) regarding malaria among rural Hausa communities in Kano State, Nigeria...
  65. Landreh M, Marklund E, Uzdavinys P, Degiacomi M, Coincon M, Gault J, et al. Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters. Nat Commun. 2017;8:13993 pubmed publisher
    ..to study the conformational stability and lipid-binding properties of the Na+/H+ exchanger NapA from Thermus thermophilus and compare this to the prototypical antiporter NhaA from Escherichia coli and the human ..
  66. Plessis P, Ojumu T, Petrik L. Waste Minimization Protocols for the Process of Synthesizing Zeolites from South African Coal Fly Ash. Materials (Basel). 2013;6:1688-1703 pubmed publisher
    ..This result could be used to establish a basis for legal and environmental aspects involved in the commission of a full-scale plant synthesizing zeolites NaP1 and analcime.
  67. Giancola S, Williams R, Gentry C. Prevalence of the Clostridium difficile BI/NAP1/027 strain across the United States Veterans Health Administration. Clin Microbiol Infect. 2018;24:877-881 pubmed publisher
    ..of Clostridium difficile infection (CDI) are thought to result partly from the emergence of the hypervirulent BI/NAP1/027 strain. Limited recent data are available on the prevalence of BI/NAP1/027 in the United States (US)...
  68. Sennato S, Carlini L, Truzzolillo D, Bordi F. Salt-induced reentrant stability of polyion-decorated particles with tunable surface charge density. Colloids Surf B Biointerfaces. 2016;137:109-20 pubmed publisher
    The electrostatic complexation between DOTAP/DOPC unilamellar liposomes and an oppositely charged polyelectrolyte (NaPA) has been investigated in a wide range of the liposome surface charge density...
  69. Niroomand M, Ghasemi S, Karimi Sari H, Kazempour Ardebili S, Amiri P, Khosravi M. Diabetes knowledge, attitude and practice (KAP) study among Iranian in-patients with type-2 diabetes: A cross-sectional study. Diabetes Metab Syndr. 2016;10:S114-9 pubmed publisher
    ..Iran and also present some successful experiences carried out for improving the knowledge, attitude, and practice (KAP) of type-2 diabetic patients. Hence, evaluation of patients' KAP seems to be needed...
  70. Ockhuis D, Kyriacos U. Renal unit practitioners' knowledge, attitudes and practice regarding the safety of unfractionated heparin for chronic haemodialysis. Curationis. 2015;38: pubmed publisher
    ..Firstly, to describe renal practitioners' self-reported knowledge, attitudes and practice (KAP) regarding the safe use of UFH and its effects; secondly, to determine an association between KAP and selected ..
  71. Chen X, D Arcy S, Radebaugh C, Krzizike D, Giebler H, Huang L, et al. Histone Chaperone Nap1 Is a Major Regulator of Histone H2A-H2B Dynamics at the Inducible GAL Locus. Mol Cell Biol. 2016;36:1287-96 pubmed publisher
    Histone chaperones, like nucleosome assembly protein 1 (Nap1), play a critical role in the maintenance of chromatin architecture...
  72. Cai H, Ye F, Michel A, Murphy G, Sasazuki S, Taylor P, et al. Helicobacter pylori blood biomarker for gastric cancer risk in East Asia. Int J Epidemiol. 2016;45:774-81 pubmed publisher
    ..Sero-positivity to 10 H. pylori antigens (Omp, CagA, VacA, HcpC, HP 0305, GroEL, NapA, HyuA, Cad, HpaA) was associated with a 1.29- to 3.26-fold increase in odds of gastric cancer...
  73. Costa C, López Ureña D, de Oliveira Assis T, Ribeiro R, Silva R, Rupnik M, et al. A MLST Clade 2 Clostridium difficile strain with a variant TcdB induces severe inflammatory and oxidative response associated with mucosal disruption. Anaerobe. 2016;40:76-84 pubmed publisher
    ..Unlike epidemic NAP1/027 strains, which are also classified to MLST Clade 2, strain ICC-45 is susceptible to fluoroquinolones and does ..
  74. Heshmat R, Salehi F, Qorbani M, Rostami M, Shafiee G, Ahadi Z, et al. Economic inequality in nutritional knowledge, attitude and practice of Iranian households: The NUTRI-KAP study. Med J Islam Repub Iran. 2016;30:426 pubmed
    ..The aim of this study was to assess the association between nutritional knowledge, attitude and practice (KAP) of Iranian households with socioeconomic status (SES)...
  75. Ueno T, Linder S, Elmberger G. Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma. Br J Cancer. 2003;88:1229-33 pubmed
    b>Napsin A is an aspartic proteinase expressed in lung and kidney. We have reported that napsin A is expressed in type II pneumocytes and in adenocarcinomas of the lung...
  76. Kawai T, Tominaga S, Hiroi S, Kameda K, Ogata S, Nakashima H, et al. Expressions of Thyroid Transcription Factor-1, Napsin A, p40, p63, CK5/6 and Desmocollin-3 in Non-Small Cell Lung Cancer, as Revealed by Imprint Cytology Using a Malinol-Based Cell-Transfer Technique. Acta Cytol. 2015;59:457-64 pubmed publisher
    ..101; squamous cell carcinoma,n = 114), we performed immunocytochemistry for thyroid transcription factor-1, napsin A, p40, p63, CK5/6 and desmocollin-3, and compared cytologic staining results with the corresponding resection...
  77. Ueno T, Linder S, Na C, Rice W, Johansson J, Weaver T. Processing of pulmonary surfactant protein B by napsin and cathepsin H. J Biol Chem. 2004;279:16178-84 pubmed
    ..These results suggest that napsin, cathepsin H, and at least one other enzyme are involved in maturation of the biologically active SP-B peptide. ..
  78. Nishino M, Hoang M, Della Pelle P, Morales Oyarvide V, Huynh T, Mark E, et al. Napsin A/p40 antibody cocktail for subtyping non-small cell lung carcinoma on cytology and small biopsy specimens. Cancer Cytopathol. 2016;124:472-84 pubmed publisher
    ..Markers for lung ACA (thyroid transcription factor 1 and napsin A) and SQCC (cytokeratin 5/6 and p40) were evaluated on tissue microarrays (TMAs) with 143 ACA and 98 SQCC ..
  79. Tang P, Chen Z. Capillary electrochromatography using knitted aromatic polymer as the stationary phase for the separation of small biomolecules and drugs. Talanta. 2018;178:650-655 pubmed publisher
    ..Here, a knitted aromatic polymer (KAP) was in-situ grown on the inner wall of the capillary column for OT-CEC for the first time...
  80. Reddy L, Al Shammari F. Evaluation of biomedical waste management in primary health care centres in Saudi Arabia: a knowledge, attitudes and practices study. East Mediterr Health J. 2017;23:637-641 pubmed
    ..This study aimed to determine the knowledge, attitudes and practices (KAP) about biomedical waste among health professionals in primary health care centres in Hail City, Saudi Arabia...
  81. Blundell T, Guruprasad K, Albert A, Williams M, Sibanda B, Dhanaraj V. The aspartic proteinases. An historical overview. Adv Exp Med Biol. 1998;436:1-13 pubmed
  82. Nishishita K, Sakai E, Okamoto K, Tsukuba T. Structural and phylogenetic comparison of napsin genes: the duplication, loss of function and human-specific pseudogenization of napsin B. Gene. 2013;517:147-57 pubmed publisher
    ..Human napsin genes are located on human chromosome 19q13, which comprises napsin A and napsin B...
  83. Chernock R, El Mofty S, Becker N, Lewis J. Napsin A expression in anaplastic, poorly differentiated, and micropapillary pattern thyroid carcinomas. Am J Surg Pathol. 2013;37:1215-22 pubmed publisher
    b>Napsin A is a sensitive and specific marker for pulmonary adenocarcinoma versus squamous cell carcinoma. However, studies have shown that napsin A is also positive in approximately 5% of papillary thyroid carcinomas...
  84. Jain D, Mallick S, Singh V, Singh G, Mathur S, Sharma M. Napsin A Expression in Anaplastic Lymphoma Kinase-positive Diffuse Large B-Cell Lymphoma: A Diagnostic Pitfall. Appl Immunohistochem Mol Morphol. 2016;24:e34-40 pubmed publisher
    b>Napsin A is frequently used to classify a tumor of unknown origin as lung primary...
  85. L M, Soliman M. The binding landscape of plasmepsin V and the implications for flap dynamics. Mol Biosyst. 2016;12:1457-67 pubmed publisher
    ..structure of PlmV is unique compared to other plasmepsins; it is stabilised internally by seven disulfide bonds, a NAP1 insert/fold is associated with the movement of the flap covering the active site and a highly conserved helix-turn-..
  86. Guo Z, Sun W, Michele Y, Zhang J, Hu D, Su H, et al. [Loss of BRCA associated protein 1 expression in malignant mesothelioma and its diagnostic application]. Zhonghua Bing Li Xue Za Zhi. 2017;46:699-703 pubmed publisher
    ..A differential diagnosis antibody panel, including calretinin, WT1, CK5/6, D2-40, CAM5.2, CEA, TTF1, Napsin A, p63 and p40 was tested in all cases...
  87. Stewart R, Rossow J, Conover J, Lobelo E, Eckel S, Signs K, et al. Do animal exhibitors support and follow recommendations to prevent transmission of variant influenza at agricultural fairs? A survey of animal exhibitor households after a variant influenza virus outbreak in Michigan. Zoonoses Public Health. 2017;: pubmed publisher
    ..at agricultural exhibitions; however, there is little information on the knowledge, attitudes, and practice (KAP) of these measures among animal exhibitors...
  88. Lyu Y, Hu C, Sun L, Qin W, Xu P, Sun J, et al. Impact of an intervention programme on knowledge, attitudes and practices of population regarding severe fever with thrombocytopenia syndrome in endemic areas of Lu'an, China. Epidemiol Infect. 2017;:1-12 pubmed publisher
    Knowledge, attitudes and practices (KAP) of the population regarding severe fever with thrombocytopenia syndrome (SFTS) in endemic areas of Lu'an in China were assessed before and after an intervention programme...
  89. Kim H, Lee K, Kim S, Rhee M. Predictive modeling of bacterial growth in ready-to-use salted napa cabbage (Brassica pekinensis) at different storage temperatures. Food Microbiol. 2018;70:129-136 pubmed publisher
    ..indicators [aerobic plate counts (APC), total coliforms (TC), and lactic acid bacteria (LAB)] in commercial salted napa cabbages during storage conditions at different temperatures (5, 22, and 30 °C, for up to 72 h) and to ..
  90. Dudzicz S, Adamczak M, Wiecek A. Clostridium Difficile Infection in the Nephrology Ward. Kidney Blood Press Res. 2017;42:844-852 pubmed publisher
    ..This may be a consequence of excessive antibiotic use and spread of the hypervirulent epidemic BI/NAP1/027 strain of Clostridium difficile...
  91. Kriegsmann M, Harms A, Longuespée R, Muley T, Winter H, Kriegsmann K, et al. Role of Conventional Immunomarkers, HNF4-a, and SATB2 in the Differential Diagnosis of Pulmonary and Colorectal Adenocarcinomas. Histopathology. 2017;: pubmed publisher
    ..Therefore, we analyzed the expression of these six markers in 1021 non-small cell lung cancers (NSCLC) including 472 ADC as well as in 80 pulmonary metastases of CRC...
  92. Koelsch G, Mares M, Metcalf P, Fusek M. Multiple functions of pro-parts of aspartic proteinase zymogens. FEBS Lett. 1994;343:6-10 pubmed
    ..Consequently, the primary structures of pro-parts reflect these functions. We discuss guidelines for formation of hypotheses derived from comparing the physiological function of aspartic proteinases and sequences of their pro-parts. ..