NAP1L1

Summary

Gene Symbol: NAP1L1
Description: nucleosome assembly protein 1 like 1
Alias: NAP1, NAP1L, NRP, nucleosome assembly protein 1-like 1, HSP22-like protein interacting protein, NAP-1-related protein
Species: human
Products:     NAP1L1

Top Publications

  1. Simon H, Mills G, Kozlowski M, Hogg D, Branch D, Ishimi Y, et al. Molecular characterization of hNRP, a cDNA encoding a human nucleosome-assembly-protein-I-related gene product involved in the induction of cell proliferation. Biochem J. 1994;297 ( Pt 2):389-97 pubmed
  2. Shikama N, Chan H, Krstic Demonacos M, Smith L, Lee C, Cairns W, et al. Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators. Mol Cell Biol. 2000;20:8933-43 pubmed
    ..interaction between p300/CBP and members of the family of nucleosome assembly proteins (NAP), which includes NAP1, NAP2, and TAF1...
  3. Asahara H, Tartare Deckert S, Nakagawa T, Ikehara T, Hirose F, Hunter T, et al. Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. Mol Cell Biol. 2002;22:2974-83 pubmed
    ..As p300 acted cooperatively with NAP-1 in stimulating transcription from a chromatin template in vitro, our results suggest a dual role of NAP-1-p300 complexes in promoting chromatin assembly and transcriptional activation. ..
  4. Rehtanz M, Schmidt H, Warthorst U, Steger G. Direct interaction between nucleosome assembly protein 1 and the papillomavirus E2 proteins involved in activation of transcription. Mol Cell Biol. 2004;24:2153-68 pubmed
    ..These results suggest that the binding of sequence-specific DNA binding proteins to hNAP-1 may be an important step contributing to the activation of transcription. ..
  5. Okuwaki M, Kato K, Shimahara H, Tate S, Nagata K. Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I. Mol Cell Biol. 2005;25:10639-51 pubmed
    ..Thus, both the acidic nature of NAP-I and its other functional structure(s) may be essential to mediate the assembly and disassembly of the dimers in NCPs. ..
  6. Okuwaki M, Kato K, Nagata K. Functional characterization of human nucleosome assembly protein 1-like proteins as histone chaperones. Genes Cells. 2010;15:13-27 pubmed publisher
    Nucleosome Assembly Protein 1 (NAP1) is a highly conserved histone chaperone protein suspected to be involved in the dynamical regulation of the histone H2A-H2B hetero-dimer...
  7. Khanafer N, Barbut F, Eckert C, Perraud M, Demont C, Luxemburger C, et al. Factors predictive of severe Clostridium difficile infection depend on the definition used. Anaerobe. 2016;37:43-8 pubmed publisher
    ..Over the past decade, the emergence of the BI/NAP1/027 strain has been linked to higher prevalence and severity of CDI...
  8. Goonawardane N, Gebhardt A, Bartlett C, Pichlmair A, Harris M. Phosphorylation of Serine 225 in Hepatitis C Virus NS5A Regulates Protein-Protein Interactions. J Virol. 2017;91: pubmed publisher
    ..of NS5A with a number of cellular proteins, in particular the nucleosome assembly protein 1-like protein 1 (NAP1L1), bridging integrator 1 (Bin1, also known as amphiphysin II), and vesicle-associated membrane protein-associated ..
  9. Jarray R, Pavoni S, Borriello L, Allain B, Lopez N, Bianco S, et al. Disruption of phactr-1 pathway triggers pro-inflammatory and pro-atherogenic factors: New insights in atherosclerosis development. Biochimie. 2015;118:151-61 pubmed publisher
    ..regulated by vascular endothelial growth factor A165 (VEGF-A165) through VEGF receptor 1 (VEGR-1) and Neuropilin-1 (NRP-1)...

More Information

Publications134 found, 100 shown here

  1. Chen M, Zhang B, Cai S, Zeng X, Ye Q, Mao X, et al. Metabolic disorder of amino acids, fatty acids and purines reflects the decreases in oocyte quality and potential in sows. J Proteomics. 2019;200:134-143 pubmed publisher
    ..of follicular fluid, serum, and urine from low reproductive performance (LRP) and normal reproductive performance (NRP) sows was conducted...
  2. Bulman Z, Chen L, Walsh T, Satlin M, Qian Y, Bulitta J, et al. Polymyxin Combinations Combat Escherichia coli Harboring mcr-1 and blaNDM-5: Preparation for a Postantibiotic Era. MBio. 2017;8: pubmed publisher
    ..filamentous MCR1_NJ cells was evident in scanning electron microscopy, suggestive of a nonreplicating persister (NRP) phenotype...
  3. Zhao P, Wang Y, Liu X, Zhu Y, Zhao H, Zhang Q, et al. Bu Shen Yi Sui capsule promotes remyelination correlating with Sema3A/NRP-1, LIF/LIFR and Nkx6.2 in mice with experimental autoimmune encephalomyelitis. J Ethnopharmacol. 2018;217:36-48 pubmed publisher
    ..The protein expressions of semaphorins (Sema) 3A, Neuropilin (NRP) -?1, leukemia inhibitory factor (LIF), LIF receptor (LIFR) and Nkx6.2 were further investigated by western blot...
  4. Lala P, Nandi P, Majumder M. Roles of prostaglandins in tumor-associated lymphangiogenesis with special reference to breast cancer. Cancer Metastasis Rev. 2018;37:369-384 pubmed publisher
    ..LECP) by binding to their primary (high affinity) receptor VEGF-R3 or secondary receptors VEGF-R2, neuropilin (NRP)2 and α9/β1 integrin...
  5. Yang N, Zhang W, He T, Xing Y. Silencing of galectin-1 inhibits retinal neovascularization and ameliorates retinal hypoxia in a murine model of oxygen-induced ischemic retinopathy. Exp Eye Res. 2017;159:1-15 pubmed publisher
    ..Western blot analysis and real-time polymerase chain reaction indicated that the expression of both neuropilin-1 (Nrp-1) and B cell lymphoma-2 (Bcl-2) decreased after intravitreal injection of Ad-Gal-1-RNAi, implying the possible ..
  6. Reichert S, Scheid S, Roth T, Herkel M, Petrova D, Linden A, et al. Semaphorin 3F Promotes Transendothelial Migration of Leukocytes in the Inflammatory Response After Survived Cardiac Arrest. Inflammation. 2019;: pubmed publisher
    ..Accumulating evidence implicates that semaphorin (Sema) 3F and its receptor neuropilin (NRP) 2 are central regulators in vascular biology...
  7. Luo F, Wang Q, Yin C, Ge Y, Hu F, Huang B, et al. Differential metabolic responses of Beauveria bassiana cultured in pupae extracts, root exudates and its interactions with insect and plant. J Invertebr Pathol. 2015;130:154-64 pubmed publisher
    ..Pathway analysis finds that fatty acid metabolism is maintained at high level but non-ribosomal peptides (NRP) synthesis is unaffected in mycelia cultured in pupae extracts...
  8. Yang Z, Xiang B, Dong D, Wang Z, Li J, Qi X. Dual receptor-specific peptides modified liposomes as VEGF siRNA vector for tumor-targeting therapy. Curr Gene Ther. 2014;14:289-99 pubmed
    ..specifically targeting low-density lipoprotein receptor (LRP) for brain tumor targeting and neuropilin-1 receptor (NRP-1) for tumor penetration, respectively...
  9. Dejda A, Mawambo G, Cerani A, Miloudi K, Shao Z, Daudelin J, et al. Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk. J Clin Invest. 2014;124:4807-22 pubmed publisher
    ..Using a murine model, we found that SEMA3A acts as a potent attractant for neuropilin-1-positive (NRP-1-positive) MPs...
  10. Wu M, Chen Y, Lee K, Chang C, Cheng T, Wu S, et al. Glycosylation-dependent galectin-1/neuropilin-1 interactions promote liver fibrosis through activation of TGF-β- and PDGF-like signals in hepatic stellate cells. Sci Rep. 2017;7:11006 pubmed publisher
    ..glycome of activated HSCs facilitated Gal-1 binding, which upon recognition of the N-glycans on neuropilin (NRP)-1, activated platelet-derived growth factor (PDGF)- and transforming growth factor (TGF)-β-like signals to ..
  11. Tian J, Glenn G, FLYER D, Zhou B, Liu Y, Sullivan E, et al. Clostridium difficile chimeric toxin receptor binding domain vaccine induced protection against different strains in active and passive challenge models. Vaccine. 2017;35:4079-4087 pubmed publisher
    ..Over the past decade, however, highly virulent epidemic strains of C. difficile (B1/NAP1/027) have emerged and are linked to an increase in morbidity and mortality...
  12. Toome K, Willmore A, Paiste P, Tobi A, Sugahara K, Kirsimäe K, et al. Ratiometric in vivo auditioning of targeted silver nanoparticles. Nanoscale. 2017;9:10094-10100 pubmed publisher
    ..tissue tropism; one peptide that favors vascular beds of the normal lungs (RPARPAR; receptor neuropilin-1, or NRP-1) and another that is selective for central nervous system vessels (CAGALCY)...
  13. Al Shareef H, Hiraoka S, Tanaka N, Shogen Y, Lee A, Bakhshishayan S, et al. Use of NRP1, a novel biomarker, along with VEGF-C, VEGFR-3, CCR7 and SEMA3E, to predict lymph node metastasis in squamous cell carcinoma of the tongue. Oncol Rep. 2016;36:2444-2454 pubmed publisher
    ..surface tyrosine kinase receptor VEGF receptor?3 (VEGFR?3); C?C motif chemokine receptor 7 (CCR7); neuropilin (NRP)1 and NRP2; and semaphorin 3E (SEMA3E)...
  14. Ying M, Shen Q, Zhan C, Wei X, Gao J, Xie C, et al. A stabilized peptide ligand for multifunctional glioma targeted drug delivery. J Control Release. 2016;243:86-98 pubmed publisher
    ..sup>LA7R) can bind specifically to vascular endothelial growth factor receptor 2 (VEGFR2) and neuropilin-1 (NRP-1) that are overexpressed on glioma cells, neovasculature and glioma vasculogenic mimicry (VM), the tumor-homing ..
  15. Nagano K, Akpan A, Warnasuriya G, Corless S, Totty N, Yang A, et al. Functional proteomic analysis of long-term growth factor stimulation and receptor tyrosine kinase coactivation in Swiss 3T3 fibroblasts. Mol Cell Proteomics. 2012;11:1690-708 pubmed publisher
    ..with novel PI3K/Akt-dependent synthesis and phosphorylations including eEF2, PRS7, RACK-1, acidic calponin, NAP1L1, Hsp73, and fascin...
  16. Garyu J, Uduman M, Stewart A, Rui J, Deng S, Shenson J, et al. Characterization of Diabetogenic CD8+ T Cells: IMMUNE THERAPY WITH METABOLIC BLOCKADE. J Biol Chem. 2016;291:11230-40 pubmed publisher
    ..this behavior, we analyzed diabetogenic CD8+ T cells that recognize a peptide from the diabetes antigen IGRP (NRP-V7-reactive) in prediabetic NOD mice and compared them to others that shared their phenotype (CD44(+)CD62L(lo)PD-1(+..
  17. LEE P, Gao N, Dike M, Shkilnyy O, Me R, Zhang Y, et al. Opposing Effects of Neuropilin-1 and -2 on Sensory Nerve Regeneration in Wounded Corneas: Role of Sema3C in Ameliorating Diabetic Neurotrophic Keratopathy. Diabetes. 2019;68:807-818 pubmed publisher
    ..The hyperglycemia-suppressed SEMA3C/NRP2 signaling may contribute to the pathogenesis of diabetic neurotrophic keratopathy, and SEMA3C might be used as an adjunctive therapeutic for treating the disease. ..
  18. Trindade C, Domingues R, Ferreira E. The epidemiology of Clostridioides difficile infection in Brazil: A systematic review covering thirty years. Anaerobe. 2019;: pubmed publisher
    ..In the 2000's, the number of CDAD cases largely increased due to the emergence of the epidemic clone named BI/NAP1 ribotype 027, responsible for causing several outbreaks in developed countries, such as Canada, the United States, ..
  19. Meshram C, Agback P, Shiliaev N, Urakova N, Mobley J, Agback T, et al. Multiple Host Factors Interact with the Hypervariable Domain of Chikungunya Virus nsP3 and Determine Viral Replication in Cell-Specific Mode. J Virol. 2018;92: pubmed publisher
    ..Interaction with NAP1L1 and NAP1L4 plays a more proviral role in vertebrate cells, while binding of SH3 domain-containing proteins to a ..
  20. Nangia S, Sunder S, Biswas R, Saili A. Endotracheal suction in term non vigorous meconium stained neonates-A pilot study. Resuscitation. 2016;105:79-84 pubmed publisher
    ..suction group' ('ET' Group; n=87) underwent tracheal suction as part of the initial steps as per the current NRP recommendations. The primary outcome was occurrence of MAS and/or death...
  21. Wang J, Wang S, Li M, Wu D, Liu F, Yang R, et al. The Neuropilin-1 Inhibitor, ATWLPPR Peptide, Prevents Experimental Diabetes-Induced Retinal Injury by Preserving Vascular Integrity and Decreasing Oxidative Stress. PLoS ONE. 2015;10:e0142571 pubmed publisher
    Neuropilin-1 (NRP-1) is a transmembrane glycoprotein. As a VEGF co-receptor, NRP1 significantly enhances VEGFR2 signaling and promotes vascular permeability and migration...
  22. Hagness M, Foss S, Sørensen D, Syversen T, Bakkan P, Dahl T, et al. Liver Transplant After Normothermic Regional Perfusion From Controlled Donors After Circulatory Death: The Norwegian Experience. Transplant Proc. 2019;51:475-478 pubmed publisher
    ..a 5-minute "no-touch" period, extracorporeal membrane oxygenation for post mortem normothermic regional perfusion (NRP) by extracorporeal membrane oxygenator circuit was established...
  23. Liu X, Yang Y, Guo X, Liu L, Wu K, Yu M. The Antiangiogenesis Effect of Pirfenidone in Wound Healing In Vitro. J Ocul Pharmacol Ther. 2017;33:693-703 pubmed publisher
    ..The expression levels of vascular endothelial growth factor-A (VEGF-A), VEGF receptor-2 (VEGFR-2), neuropilin-1(NRP-1), and their downstream signaling proteins p-PI3K, PI3K, p-AKT, AKT, p-mTOR, and mechanistic target of rapamycin (..
  24. Fountain E, Moses M, Park L, Woods C, Arepally G. Thrombocytopenia in hospitalized patients with severe clostridium difficile infection. J Thromb Thrombolysis. 2017;43:38-42 pubmed publisher
    ..community), NAP1/027 strain, and disease severity has not been examined...
  25. Ijaz F, Hatanaka Y, Hatanaka T, Tsutsumi K, Iwaki T, Umemura K, et al. Proper cytoskeletal architecture beneath the plasma membrane of red blood cells requires Ttll4. Mol Biol Cell. 2017;28:535-544 pubmed publisher
    ..Immunoprecipitation using the anti-glutamylation antibody GT335 revealed nucleosome assembly protein 1 (NAP1) to be the sole target of TTLL4 in the RBCs, and NAP1 glutamylation was completely lost in Ttll4-knockout ..
  26. Goldberg E, Bhalodia S, Jacob S, Patel H, Trinh K, Varghese B, et al. Clostridium difficile infection: A brief update on emerging therapies. Am J Health Syst Pharm. 2015;72:1007-12 pubmed publisher
    ..difficile strains (including the hypervirulent BI/NAP1/027 strain) has yielded encouraging results in early clinical trials...
  27. Lee J, Kim E, Ryu S, Choi C, Choi K. Combined inhibition of vascular endothelial growth factor receptor signaling with temozolomide enhances cytotoxicity against human glioblastoma cells via downregulation of Neuropilin-1. J Neurooncol. 2016;128:29-34 pubmed publisher
    ..Treatment with TMZ specifically reduced the expression of NRP-1, a coreceptor of VEGF but not those of VEGF-R1 and VEGF-R2...
  28. Messer S, Axell R, Colah S, White P, Ryan M, Page A, et al. Functional assessment and transplantation of the donor heart after circulatory death. J Heart Lung Transplant. 2016;35:1443-1452 pubmed publisher
    ..Normothermic regional perfusion (NRP) was used to restore function to the arrested DCD heart within the donor after exclusion of the cerebral ..
  29. Liu B. [Fulminant Clostridium difficile colitis: new challenges in critical care medicine]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:564-567 pubmed publisher
    ..In particular, the recently discovered mutant CD strain NAP1/BI/ribotype 027 has high pathogenicity in the global epidemic and its outbreak...
  30. Fujii T, Shimada K, Asano A, Tatsumi Y, Yamaguchi N, Yamazaki M, et al. MicroRNA-331-3p Suppresses Cervical Cancer Cell Proliferation and E6/E7 Expression by Targeting NRP2. Int J Mol Sci. 2016;17: pubmed publisher
    ..b>NRP-2 also regulates the expression of E6/E7 and keratinocyte differentiation markers...
  31. Devera T, Lang G, Lanis J, Rampuria P, Gilmore C, James J, et al. Memory B Cells Encode Neutralizing Antibody Specific for Toxin B from the Clostridium difficile Strains VPI 10463 and NAP1/BI/027 but with Superior Neutralization of VPI 10463 Toxin B. Infect Immun. 2016;84:194-204 pubmed publisher
    ..CTD was produced from the historical VPI 10463 strain (CTD1) and from the hypervirulent strain NAP1/BI/027 (CTD2)...
  32. Malik S, Saito H, Takaoka M, Miki Y, Nakanishi A. BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein. Cell Cycle. 2016;15:2145-2156 pubmed
    ..The double depletion of BRCA2 and C-Nap1 caused a larger dispersion of centrosome distances than the silencing of C-Nap1...
  33. Pagani E, Ruffini F, Antonini Cappellini G, Scoppola A, Fortes C, Marchetti P, et al. Placenta growth factor and neuropilin-1 collaborate in promoting melanoma aggressiveness. Int J Oncol. 2016;48:1581-9 pubmed publisher
    ..VEGF) family, which shares with VEGF-A the tyrosine kinase receptor VEGFR-1 and the co-receptor neuropilin-1 (NRP-1)...
  34. Zhu X, Chen Y, Zhang N, Zheng Z, Zhao F, Liu N, et al. Molecular characterization and expression analyses of ST8Sia II and IV in piglets during postnatal development: lack of correlation between transcription and posttranslational levels. Glycoconj J. 2015;32:715-28 pubmed publisher
    ..of the piglet ST8Sia II and determine the mRNA expression levels of ST8Sia II, ST8Sia IV, NCAM and neuropilin-2 (NRP-2), also a carrier protein of polySia, during postnatal development...
  35. Endres B, Basseres E, Khaleduzzaman M, Alam M, Chesnel L, Garey K. Evaluating the Effects of Surotomycin Treatment on Clostridium difficile Toxin A and B Production, Immune Response, and Morphological Changes. Antimicrob Agents Chemother. 2016;60:3519-23 pubmed publisher
    ..Time-kill curve assays were performed using strain R20291 (BI/NAP1/027) at supra-MICs (4× and 40×) and sub-MICs (0.5×) of surotomycin and comparators...
  36. Chen L, Zhang G, Shi Y, Qiu R, Khan A. Neuropilin-1 (NRP-1) and Magnetic Nanoparticles, a Potential Combination for Diagnosis and Therapy of Gliomas. Curr Pharm Des. 2015;21:5434-49 pubmed
    In this review, Neuropilin-1 (NRP-1) has been focused as a novel molecular target for potential treatment of gliomas. The properties of NRP-1 were described briefly...
  37. Yan Y, Yin P, Gong H, Xue Y, Zhang G, Fang B, et al. Nucleosome Assembly Protein 1-Like 1 (Nap1l1) Regulates the Proliferation of Murine Induced Pluripotent Stem Cells. Cell Physiol Biochem. 2016;38:340-50 pubmed publisher
    To investigate whether nucleosome assembly protein 1-like 1 (Nap1l1) regulates the proliferation of induced pluripotent stem cells (iPSC) and the potential mechanisms...
  38. Niermeyer S. From the Neonatal Resuscitation Program to Helping Babies Breathe: Global impact of educational programs in neonatal resuscitation. Semin Fetal Neonatal Med. 2015;20:300-8 pubmed publisher
    Two educational programs in neonatal resuscitation, the Neonatal Resuscitation Program (NRP) and Helping Babies Breathe (HBB) have found widespread acceptance globally as practical tools to improve newborn survival and reduce death from ..
  39. Wieczorkiewicz J, Lopansri B, Cheknis A, Osmolski J, Hecht D, Gerding D, et al. Fluoroquinolone and Macrolide Exposure Predict Clostridium difficile Infection with the Highly Fluoroquinolone- and Macrolide-Resistant Epidemic C. difficile Strain BI/NAP1/027. Antimicrob Agents Chemother. 2016;60:418-23 pubmed publisher
    ..We performed a retrospective case-control study of patients infected with the epidemic BI/NAP1/027 strain in a U.S. hospital following recognition of increased CDI severity and culture of stools positive by C...
  40. Yao Z, Wu D, Liu J, Wu W, Zhao H, Tang J. Recycling of typical difficult-to-treat e-waste: Synthesize zeolites from waste cathode-ray-tube funnel glass. J Hazard Mater. 2017;324:673-680 pubmed publisher
    ..0. At the temperature of 110°C (pressure 1.43bar), NaA formed with a mixture of NaP1 and Faujasite...
  41. Worton L, Shi Y, Smith E, Barry S, Gonda T, Whitehead J, et al. Ectodermal-Neural Cortex 1 Isoforms Have Contrasting Effects on MC3T3-E1 Osteoblast Mineralization and Gene Expression. J Cell Biochem. 2017;118:2141-2150 pubmed publisher
    ..Here we investigated the role of a known Wnt target, ENC1 (ectodermal-neural cortex 1; NRP/B), in osteoblast differentiation...
  42. Ruffini F, Levati L, Graziani G, Caporali S, Atzori M, D Atri S, et al. Platelet-derived growth factor-C promotes human melanoma aggressiveness through activation of neuropilin-1. Oncotarget. 2017;8:66833-66848 pubmed publisher
    ..Neuropilin-1 (NRP-1), a co-receptor for vascular endothelial growth factor-A (VEGF-A) tyrosine kinase receptors (VEGFRs), has been ..
  43. Chen X, D Arcy S, Radebaugh C, Krzizike D, Giebler H, Huang L, et al. Histone Chaperone Nap1 Is a Major Regulator of Histone H2A-H2B Dynamics at the Inducible GAL Locus. Mol Cell Biol. 2016;36:1287-96 pubmed publisher
    Histone chaperones, like nucleosome assembly protein 1 (Nap1), play a critical role in the maintenance of chromatin architecture...
  44. Zhang G, Chen L, Sun K, Khan A, Yan J, Liu H, et al. Neuropilin-1 (NRP-1)/GIPC1 pathway mediates glioma progression. Tumour Biol. 2016;37:13777-13788 pubmed
    Glioma occurs due to multi-gene abnormalities. Neuropilin-1 (NRP-1), as a transmembrane protein, involves in glioma proliferation, invasion, and migration, as well as tumor angiogenesis...
  45. Huang S, Lien J, Kuo S, Huang T. DDA suppresses angiogenesis and tumor growth of colorectal cancer in vivo through decreasing VEGFR2 signaling. Oncotarget. 2016;7:63124-63137 pubmed publisher
    ..In addition, NRP-1 siRNA reduced VEGF-A's enhancing effects in VEGFR2, FAK and Akt phosphorylation and cell proliferation in HUVECs...
  46. Van Acker N, Ragé M, Vermeirsch H, Schrijvers D, Nuydens R, Byttebier G, et al. NRP-1 Receptor Expression Mismatch in Skin of Subjects with Experimental and Diabetic Small Fiber Neuropathy. PLoS ONE. 2016;11:e0161441 pubmed publisher
    ..are defective in diabetes, we focused on studying the key regulator of these processes, the neuropilin-1 (NRP-1)/semaphorin pathway...
  47. Ngu S, Tan M, Subramanian P, Abdul Rahman R, Kamaruzzaman S, Chin A, et al. Pain Assessment Using Self-reported, Nurse-reported, and Observational Pain Assessment Tools among Older Individuals with Cognitive Impairment. Pain Manag Nurs. 2015;16:595-601 pubmed publisher
    ..SRP), observational pain using the Pain Assessment in Advanced Dementia (PAINAD) tool, and nurse-reported pain (NRP)...
  48. Roth B, Varney K, Rustandi R, Weber D. (1)H(N), (13)C, and (15)N resonance assignments of the CDTb-interacting domain (CDTaBID) from the Clostridium difficile binary toxin catalytic component (CDTa, residues 1-221). Biomol NMR Assign. 2016;10:335-9 pubmed publisher
    ..difficile strain, NAP1. Along with the large Clostridial toxins expressed by non-epidemic strains, C...
  49. Rodriguez P, Pelletier J, Price G, Zannis Hadjopoulos M. NAP-2: histone chaperone function and phosphorylation state through the cell cycle. J Mol Biol. 2000;298:225-38 pubmed
    ..Finally, indirect immunofluorescence shows that NAP-2 is present during metaphase of HeLa and COS cells, and its localization is distinct from metaphase chromosomes. ..
  50. Lee Montiel F, Li P, Imoukhuede P. Quantum dot multiplexing for the profiling of cellular receptors. Nanoscale. 2015;7:18504-14 pubmed publisher
    ..angiogenic receptors in the vascular endothelial growth factor family (VEGFR1, VEGFR2 and VEGFR3) and Neuropilin (NRP) family (NRP1 and NRP2), using multicolor quantum dots (Qdots)...
  51. Pellet Many C, Mehta V, Fields L, Mahmoud M, Lowe V, Evans I, et al. Neuropilins 1 and 2 mediate neointimal hyperplasia and re-endothelialization following arterial injury. Cardiovasc Res. 2015;108:288-98 pubmed publisher
    ..and proteins increased significantly following arterial injury, and immunofluorescent staining revealed neointimal NRP expression...
  52. Yasmin T, Ali M, Haque S, Hossain M. Interaction of Quercetin of Onion with Axon Guidance Protein Receptor, NRP-1 Plays Important Role in Cancer Treatment: An In Silico Approach. Interdiscip Sci. 2017;9:184-191 pubmed publisher
    Neuropilin-1 (NRP-1) is a transmembrane glycoprotein receptor whose distinct sites bind semaphorins and vascular endothelial growth factor family members to mediate the role of these ligands in neuronal axon guidance and angiogenesis, ..
  53. Onishi M, Pringle J, Cross F. Evidence That an Unconventional Actin Can Provide Essential F-Actin Function and That a Surveillance System Monitors F-Actin Integrity in Chlamydomonas. Genetics. 2016;202:977-96 pubmed publisher
    ..A highly divergent actin gene, NAP1, is upregulated in ida5-1 cells, but it has been unclear whether NAP1 can form filaments or provide actin function...
  54. Gomez E, Montgomery S, Alby K, Robinson D, Roundtree S, Blecker Shelly D, et al. Poor yield of Clostridium difficile testing algorithms using glutamate dehydrogenase antigen and C. difficile toxin enzyme immunoassays in a pediatric population with declining prevalence of clostridium difficile strain BI/NAP1/027. Diagn Microbiol Infect Dis. 2018;91:229-232 pubmed publisher
    ..9.6% of samples were ribotype 027. Algorithms may detect CDI with lower sensitivity compared to molecular methods in children. This may be related to low prevalence of NAP-1/ribotype 027. ..
  55. Campbell B, Hofstad A, Sreekanta S, Fu F, Kono T, O Rourke J, et al. Fast neutron-induced structural rearrangements at a soybean NAP1 locus result in gnarled trichomes. Theor Appl Genet. 2016;129:1725-38 pubmed publisher
    Three adjacent and distinct sequence rearrangements were identified at a NAP1 locus in a soybean mutant. Genetic dissection and validation revealed the function of this gene in soybean trichome development. A soybean (Glycine max (L...
  56. Qi L, Tang Y, Wang L, He W, Pan H, Nie R, et al. Role of Rho-mediated ROCK-Semaphorin3A signaling pathway in the pathogenesis of Parkinson's disease in a mouse model. J Neurol Sci. 2016;370:21-26 pubmed publisher
    ..The mRNA and protein expressions of Rho, ROCK, Sema3A, PlexinA and NRP-1 were detected using quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting...
  57. Ren Y, Sagers J, Landegger L, Bhatia S, Stankovic K. Tumor-Penetrating Delivery of siRNA against TNF? to Human Vestibular Schwannomas. Sci Rep. 2017;7:12922 pubmed publisher
    ..were selectively taken up by primary VS cultures in vitro via interactions with ?v?3/?5 integrins and neuropilin-1 (NRP-1). Cellular uptake was inhibited by a neutralizing antibody against ?v integrin in a dose-dependent manner...
  58. Hu C, Chen X, Huang Y, Chen Y. Co-administration of iRGD with peptide HPRP-A1 to improve anticancer activity and membrane penetrability. Sci Rep. 2018;8:2274 pubmed publisher
    ..efficient cell membrane penetration peptide targeting to αvβ3 integrins and neuropilin-1 (NRP-1) receptors, which show high expression in many tumor cells...
  59. Bondeva T, Wolf G. Role of Neuropilin-1 in Diabetic Nephropathy. J Clin Med. 2015;4:1293-311 pubmed publisher
    ..DN is characterized by renal injury resulting in proteinuria. Neuropilin-1 (NRP-1) is a single-pass transmembrane receptor protein devoid of enzymatic activity...
  60. Hu C, Jiang X. The effect of anti-angiogenic drugs on regulatory T cells in the tumor microenvironment. Biomed Pharmacother. 2017;88:134-137 pubmed publisher
    ..number and function of Tregs by targeting vascular endothelial growth factor receptor 2 (VEGFR-2) and neuropilin-1 (NRP-1) on the cell surface...
  61. Barber Ansón M, García Herrera A, Roldán Ramírez J, Loinaz Bordonabe M, Agudo Pascual O, Osés Munarriz I. [Combined thorax-abdomen extraction in a Maastricht type III donor]. An Sist Sanit Navar. 2018;41:117-121 pubmed publisher
    ..carried out in only twelve centres in Spain, while the combined use of abdominal normothermic regional perfusion (NRP) is even more exceptional...
  62. Yue H, Fang H, Wei S, Hayes J, Lee T. Single-Molecule Studies of the Linker Histone H1 Binding to DNA and the Nucleosome. Biochemistry. 2016;55:2069-77 pubmed publisher
    ..We found that histone chaperone Nap1 readily dissociates H1 from DNA and superstoichiometrically bound H1 from the nucleosome, supporting a hypothesis ..
  63. Wang Q, Wang P, Meng P, Han C, Yue S. Intensive training accelerates the recovery of motor functions following cerebral ischemia-reperfusion in MCAO rats. Eur Rev Med Pharmacol Sci. 2016;20:3839-3852 pubmed
    ..the effects of intensive training on the expression of semaphorin 3A (Sema3A) and its receptor Neuropilin-1 (NRP-1)...
  64. Hertlein G, Seiffert M, Gensel S, Garcia Gonzalez E, Ebeling J, Skobalj R, et al. Biological Role of Paenilarvins, Iturin-Like Lipopeptide Secondary Metabolites Produced by the Honey Bee Pathogen Paenibacillus larvae. PLoS ONE. 2016;11:e0164656 pubmed publisher
    ..larvae. Recently, several non-ribosomally produced peptides (NRP) and peptide/polyketide (NRP/PK) hybrids produced by P. larvae were identified...
  65. Liu X, Lin P, Perrett I, Lin J, Liao Y, Chang C, et al. Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer. J Clin Invest. 2017;127:2007-2018 pubmed publisher
    ..on abnormal leaky vasculature for tumor access, a transcytosis transport pathway that is regulated by neuropilin-1 (NRP-1) has recently been reported...
  66. Morgan D, Leekha S, Croft L, Burnham C, Johnson J, Pineles L, et al. The Importance of Colonization with Clostridium difficile on Infection and Transmission. Curr Infect Dis Rep. 2015;17:499 pubmed publisher
    ..for such an increase are unknown but may relate to antibiotic use and evolution of a new, pathogenic strain, NAP1/BI/027. The Centers for Disease Control and Prevention (CDC) identifies C...
  67. Aguilar Gurrieri C, Larabi A, Vinayachandran V, Patel N, Yen K, Reja R, et al. Structural evidence for Nap1-dependent H2A-H2B deposition and nucleosome assembly. EMBO J. 2016;35:1465-82 pubmed publisher
    b>Nap1 is a histone chaperone involved in the nuclear import of H2A-H2B and nucleosome assembly...
  68. Thabit A, Housman S, Burnham C, Nicolau D. Association of healthcare exposure with acquisition of different Clostridium difficile strain types in patients with recurrent infection or colonization after clinical resolution of initial infection. J Hosp Infect. 2016;92:167-72 pubmed publisher
    ..Patients did not differ with regard to age, sex, and whether the initial infection was with the BI/NAP1/027 strain. Ribotyping revealed that two out of five patients had recurrence attributed to a different strain type...
  69. Wang S, Gao X, Shen G, Wang W, Li J, Zhao J, et al. Interleukin-10 deficiency impairs regulatory T cell-derived neuropilin-1 functions and promotes Th1 and Th17 immunity. Sci Rep. 2016;6:24249 pubmed publisher
    ..IL-10 abrogation efficiently induces Treg formation but dampens tumoral neuropilin-1 (Nrp-1) Treg signaling, which simultaneously augments Th1 and Th17 immunity...
  70. Costa C, López Ureña D, de Oliveira Assis T, Ribeiro R, Silva R, Rupnik M, et al. A MLST Clade 2 Clostridium difficile strain with a variant TcdB induces severe inflammatory and oxidative response associated with mucosal disruption. Anaerobe. 2016;40:76-84 pubmed publisher
    ..Unlike epidemic NAP1/027 strains, which are also classified to MLST Clade 2, strain ICC-45 is susceptible to fluoroquinolones and does ..
  71. Parker M, Vander Kooi C. Plate-Based Assay for Measuring Direct Semaphorin-Neuropilin Interactions. Methods Mol Biol. 2017;1493:73-87 pubmed
    ..family members are secreted and provide long-range guidance cues through two receptor families: neuropilins (Nrp) and plexins. Nrp is uniquely required for high-affinity Sema3 binding and signaling...
  72. Niles D, Cines C, Insley E, Foglia E, Elci O, Skåre C, et al. Incidence and characteristics of positive pressure ventilation delivered to newborns in a US tertiary academic hospital. Resuscitation. 2017;115:102-109 pubmed publisher
    The Neonatal Resuscitation Program (NRP) guidelines recommend positive pressure ventilation (PPV) in the first 60s of life to support perinatal transition in non-breathing newborns...
  73. Kho Y, Kim S, Jiang C, Barma D, Kwon S, Cheng J, et al. A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. Proc Natl Acad Sci U S A. 2004;101:12479-84 pubmed
  74. Eckey M, Hong W, Papaioannou M, Baniahmad A. The nucleosome assembly activity of NAP1 is enhanced by Alien. Mol Cell Biol. 2007;27:3557-68 pubmed
    ..The nucleosome assembly protein 1, NAP1, assembles nucleosomes independent of DNA synthesis and was shown to enhance coactivator-mediated gene expression, ..
  75. Lee M, Park J. Pathway analysis in HEK 293T cells overexpressing HIV-1 tat and nucleocapsid. J Microbiol Biotechnol. 2009;19:1103-8 pubmed
    ..The results indicate that the up- and downregulated genes regulate HIV-1 replication and proliferation, and viral entry. ..
  76. Muller M, Jacob Y, Jones L, Weiss A, Brino L, Chantier T, et al. Large scale genotype comparison of human papillomavirus E2-host interaction networks provides new insights for e2 molecular functions. PLoS Pathog. 2012;8:e1002761 pubmed publisher
    ..These include transcription regulation, regulation of apoptosis, RNA processing, ubiquitination and intracellular trafficking. The present work provides an overview of E2 biological functions across multiple HPV genotypes. ..
  77. Mansouri S, Wang S, Frappier L. A role for the nucleosome assembly proteins TAF-I? and NAP1 in the activation of BZLF1 expression and Epstein-Barr virus reactivation. PLoS ONE. 2013;8:e63802 pubmed publisher
    ..Using RNA interference, we show that nucleosome assembly proteins NAP1 and TAF-I positively contribute to EBV reactivation in epithelial cells through the induction of BZLF1 expression...
  78. Hamp J, Löwer A, Dottermusch Heidel C, Beck L, Moussian B, Flötenmeyer M, et al. Drosophila Kette coordinates myoblast junction dissolution and the ratio of Scar-to-WASp during myoblast fusion. J Cell Sci. 2016;129:3426-36 pubmed publisher
    ..Severe defects in myoblast fusion are caused by the loss of Kette (a homolog of Nap1 and Hem-2, also known as NCKAP1 and NCKAP1L, respectively), a member of the regulatory complex formed by Scar or ..
  79. Lee J, Lee T. Single-Molecule Investigations on Histone H2A-H2B Dynamics in the Nucleosome. Biochemistry. 2017;56:977-985 pubmed publisher
    ..the early kinetics of H2A-H2B dimer dissociation triggered by high salt concentration and by histone chaperone Nap1. The results reveal that dimer displacement requires DNA unwrapping in the vast majority of the nucleosomes in the ..
  80. Bloudoff K, Schmeing T. Structural and functional aspects of the nonribosomal peptide synthetase condensation domain superfamily: discovery, dissection and diversity. Biochim Biophys Acta Proteins Proteom. 2017;1865:1587-1604 pubmed publisher
    ..The other family members can replace the C domain in NRP synthesis, can work in concert with a C domain, or can fulfill diverse and novel functions...
  81. Tamez Torres K, Torres González P, Leal Vega F, García Alderete A, López García N, Mendoza Aguilar R, et al. Impact of Clostridium difficile infection caused by the NAP1/RT027 strain on severity and recurrence during an outbreak and transition to endemicity in a Mexican tertiary care center. Int J Infect Dis. 2017;65:44-49 pubmed publisher
    ..The presence of virulence factors among non-RT027 C. difficile strains underscores the importance of performing molecular epidemiology surveillance. ..
  82. Giancola S, Williams R, Gentry C. Prevalence of the Clostridium difficile BI/NAP1/027 strain across the United States Veterans Health Administration. Clin Microbiol Infect. 2018;24:877-881 pubmed publisher
    ..of Clostridium difficile infection (CDI) are thought to result partly from the emergence of the hypervirulent BI/NAP1/027 strain. Limited recent data are available on the prevalence of BI/NAP1/027 in the United States (US)...
  83. Attia M, Forster A, Rachez C, Freemont P, Avner P, Rogner U. Interaction between nucleosome assembly protein 1-like family members. J Mol Biol. 2011;407:647-60 pubmed publisher
    ..interacting with NAP1L2, including the ubiquitously expressed members of the nucleosome assembly protein family, NAP1L1 and NAP1L4...
  84. Machida S, Takaku M, Ikura M, Sun J, Suzuki H, Kobayashi W, et al. Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1. Sci Rep. 2014;4:4863 pubmed publisher
    ..In this study, we found that a histone chaperone, Nap1, accumulates on DSB sites in human cells, and DSB repair is substantially decreased in Nap1-knockdown cells...
  85. Laghmani K, Beck B, Yang S, Seaayfan E, Wenzel A, Reusch B, et al. Polyhydramnios, Transient Antenatal Bartter's Syndrome, and MAGED2 Mutations. N Engl J Med. 2016;374:1853-63 pubmed publisher
    ..MAGE-D2 is essential for fetal renal salt reabsorption, amniotic fluid homeostasis, and the maintenance of pregnancy. (Funded by the University of Groningen and others.). ..
  86. von Eichel Streiber A, Paik W, Knight K, Gisch K, Nadjafi K, Decker C, et al. Induction of antitoxin responses in Clostridium-difficile-infected patients compared to healthy blood donors. Anaerobe. 2016;41:91-103 pubmed publisher
    ..Systemic responses to TcdB and mucosal responses to TcdA predominated. Among patients infected with the NAP1/027/BI strain, systemic IgG-anti-TcdB responses were particularly elevated...
  87. Simón Gracia L, Hunt H, Scodeller P, Gaitzsch J, Kotamraju V, Sugahara K, et al. iRGD peptide conjugation potentiates intraperitoneal tumor delivery of paclitaxel with polymersomes. Biomaterials. 2016;104:247-57 pubmed publisher
    ..A tumor homing peptide, iRGD, harbors a cryptic C-end Rule (CendR) motif that is responsible for neuropilin-1 (NRP-1) binding and for triggering extravasation and tumor penetration of the peptide...
  88. Yelland T, Djordjevic S. Crystal Structure of the Neuropilin-1 MAM Domain: Completing the Neuropilin-1 Ectodomain Picture. Structure. 2016;24:2008-2015 pubmed publisher
    ..The MAM domain of NRP, which has previously been implicated in receptor multimerization, was the only portion of the ectopic domain of ..
  89. Chiliza T, Pillay M, Pillay B. Identification of unique essential proteins from a Mycobacterium tuberculosis F15/LAM4/KZN phage secretome library. Pathog Dis. 2017;75: pubmed publisher
    ..Using bioinformatics tools and databases, 10 proteins essential for in vivo growth and survival of Mtb (Nrp, PssA, MmpL5, SirA, GatB, EspA, TopA, EccCa1, Rv1634 and Rv3103c) were identified...
  90. Antosz W, Pfab A, Ehrnsberger H, Holzinger P, Köllen K, Mortensen S, et al. The Composition of the Arabidopsis RNA Polymerase II Transcript Elongation Complex Reveals the Interplay between Elongation and mRNA Processing Factors. Plant Cell. 2017;29:854-870 pubmed publisher
    ..Additionally, NAP1 histone chaperones, ATP-dependent chromatin remodeling factors, and some histone-modifying enzymes including ..
  91. Minambres E, Rubio J, Coll E, Dominguez Gil B. Donation after circulatory death and its expansion in Spain. Curr Opin Organ Transplant. 2017;: pubmed publisher
    ..This article summarizes the development of DCD in Spain and presents recent Spanish contributions to gain knowledge on the potential benefits and the practical use of normothermic regional perfusion (nRP).
  92. Bhide G, Zapater J, Colley K. Autopolysialylation of polysialyltransferases is required for polysialylation and polysialic acid chain elongation on select glycoprotein substrates. J Biol Chem. 2018;293:701-716 pubmed publisher
    ..Here, we compared the PBR sequence requirements for NCAM, neuropilin-2 (NRP-2), and synaptic cell adhesion molecule 1 (SynCAM 1) for polysialylation by their respective polySTs...