NANOS3

Summary

Gene Symbol: NANOS3
Description: nanos C2HC-type zinc finger 3
Alias: NANOS1L, NOS3, ZC2HC12C, nanos homolog 3
Species: human
Products:     NANOS3

Top Publications

  1. Julaton V, Reijo Pera R. NANOS3 function in human germ cell development. Hum Mol Genet. 2011;20:2238-50 pubmed publisher
    ..We observed that NANOS-1, -2 and -3 mRNAs and proteins were expressed in human gonads. We also noted that NANOS3 was expressed in germ cells throughout spermatogenesis and oogenesis and thus, focused further efforts on this ..
  2. Tsuda M, Sasaoka Y, Kiso M, Abe K, Haraguchi S, Kobayashi S, et al. Conserved role of nanos proteins in germ cell development. Science. 2003;301:1239-41 pubmed
    ..We report the cloning and the functional analyses of nanos2 and nanos3 in mice. These genes are differentially expressed in mouse PGCs...
  3. Qin Y, Zhao H, Kovanci E, Simpson J, Chen Z, Rajkovic A. Mutation analysis of NANOS3 in 80 Chinese and 88 Caucasian women with premature ovarian failure. Fertil Steril. 2007;88:1465-7 pubmed
    b>NANOS3 encodes an RNA-binding protein and has a conserved function in germ cell development. Our objective was to investigate whether mutations in NANOS3 were present in Chinese and Caucasian women with premature ovarian failure...
  4. Ruan X, Chen T, Wang X, Li Y. Suxiao Jiuxin Pill protects cardiomyocytes against mitochondrial injury and alters gene expression during ischemic injury. Exp Ther Med. 2017;14:3523-3532 pubmed publisher
    ..mitogen-activated protein kinase (Mapk)11-14, Mapk kinase kinase kinase 1 (Map4k1), Mas1, nitric oxide synthase 3 (Nos3), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit ? (Pik3ca), phospholipase A2 group 4A, rap ..
  5. Cheserek M, Wu G, Li L, Li L, Karangwa E, Shi Y, et al. Cardioprotective effects of lipoic acid, quercetin and resveratrol on oxidative stress related to thyroid hormone alterations in long-term obesity. J Nutr Biochem. 2016;33:36-44 pubmed publisher
    ..increase in TR?1 and reduction in expression of the deiodinase iodothyronine DIO1, threonine protein kinase and NOS3 as well as up-regulation of AT1?, ACE, ATP1B1, GSK3? and Cja1 genes also occurred in HFD mice...
  6. Waleh N, Barrette A, Dagle J, Momany A, Jin C, Hills N, et al. Effects of Advancing Gestation and Non-Caucasian Race on Ductus Arteriosus Gene Expression. J Pediatr. 2015;167:1033-41.e2 pubmed publisher
    ..Two genes, SLCO2A1 and NOS3, (involved with prostaglandin reuptake/metabolism and nitric oxide production, respectively) were consistently ..
  7. Mascheck L, Sharifpanah F, Tsang S, Wartenberg M, Sauer H. Stimulation of cardiomyogenesis from mouse embryonic stem cells by nuclear translocation of cardiotrophin-1. Int J Cardiol. 2015;193:23-33 pubmed publisher
    ..Moreover, CT-1 treatment increased ROS, followed by NO generation and NOS3 activation. During ES cell differentiation CT-1 was translocated to the cell nucleus...
  8. Friedrich V, Bi W, Sehba F. Sexual dimorphism in gene expression after aneurysmal subarachnoid hemorrhage. Neurol Res. 2015;37:1054-9 pubmed publisher
    ..3 h after surgery and assayed for expression of thrombomodulin (Thbd), endothelial nitric oxide synthase (eNos;Nos3), intracellular adhesion molecule-1 (Icam1), vascular endothelial growth factor (Vegf), interleukin-1beta (Il1β) ..
  9. Cuevas A, Niu J, Zhong M, Liberda E, Ghio A, Qu Q, et al. Metal rich particulate matter impairs acetylcholine-mediated vasorelaxation of microvessels in mice. Part Fibre Toxicol. 2015;12:14 pubmed publisher
    ..Significant increases in gene expression (TNF-α, IL-6, Nos3; p<0.01; NOX4; p<0...

More Information

Publications84

  1. Li S, Yang J, Wang L, Du F, Zhao J, Fang R. Expression profile of microRNAs in porcine alveolar macrophages after Toxoplasma gondii infection. Parasit Vectors. 2019;12:65 pubmed publisher
    ..and ssc-miR-143-3p were predicted to regulate nitric oxide synthase 1 (NOS1) and nitric oxide synthase 3 (NOS3), respectively, which play essential roles in synthesizing nitric oxide (NO) by oxidizing L-arginine...
  2. Kanwar J, Kanwar R, Burrow H, Baratchi S. Recent advances on the roles of NO in cancer and chronic inflammatory disorders. Curr Med Chem. 2009;16:2373-94 pubmed
    ..of the enzyme: neuronal NOS (nNOS, also called NOS1), inducible NOS (iNOS or NOS2), and endothelial NOS (eNOS or NOS3). It is now known that each of these isoforms may be expressed in a variety of tissues and cell types...
  3. Hazra S, Jarajapu Y, Stepps V, Caballero S, Thinschmidt J, Sautina L, et al. Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model. Diabetologia. 2013;56:644-53 pubmed publisher
    ..increase in SP-HSCs residing in hypoxic regions of BM, decreased EPC numbers, and reduced eNos (also known as Nos3) but increased iNos (also known as Nos2) and oxidative stress-related genes...
  4. Chen D, Feng L, Hodges J, Lechuga T, Zhang H. Human trophoblast-derived hydrogen sulfide stimulates placental artery endothelial cell angiogenesis. Biol Reprod. 2017;97:478-489 pubmed publisher
    ..H2S donors activated endothelial nitric oxide synthase (NOS3), v-AKT murine thymoma viral oncogene homolog 1 (AKT1), and extracellular signal-activated kinase 1/2 (mitogen-..
  5. Du X, Wang B, Liu X, Liu X, He Y, Zhang Q, et al. Comparative transcriptome analysis of ovary and testis reveals potential sex-related genes and pathways in spotted knifejaw Oplegnathus punctatus. Gene. 2017;637:203-210 pubmed publisher
    ..bmp15, nanos3, sox9 and amh were likely to function in the regulation of gonad physiology and germ line cells maintenance in ..
  6. Yang X, Yue H, Ye H, Li C, Wei Q. Identification of a germ cell marker gene, the dead end homologue, in Chinese sturgeon Acipenser sinensis. Gene. 2015;558:118-25 pubmed publisher
    ..Zebrafish PGCs were clearly visualized at 24h post-fertilization by co-injecting RFP-Asdnd 3' UTR and GFP-nos3 3' UTR mRNA, indicating that dnd 3' UTR has a conserved function among teleosts...
  7. Meesters D, Neubert S, Wijnands K, Heyer F, Zeiter S, Ito K, et al. Deficiency of inducible and endothelial nitric oxide synthase results in diminished bone formation and delayed union and nonunion development. Bone. 2016;83:111-8 pubmed publisher
    ..followed by plate-screw osteosynthesis was performed in the left leg of 20-24week old wild type, Nos2(-/-) and Nos3(-/-) mice. Contralateral unfractured legs were used as a control...
  8. England J, Pang K, Parnall M, Haig M, Loughna S. Cardiac troponin T is necessary for normal development in the embryonic chick heart. J Anat. 2016;229:436-49 pubmed publisher
    ..developing heart, quantitative PCR was performed to determine the expression of the shear stress responsive gene NOS3 and the conduction gene TBX3. Both genes were differentially expressed compared to controls...
  9. Mercado Gómez O, Córdova Dávalos L, García Betanzo D, Rocha L, Alonso Vanegas M, Cienfuegos J, et al. Overexpression of inflammatory-related and nitric oxide synthase genes in olfactory bulbs from frontal lobe epilepsy patients. Epilepsy Res. 2018;148:37-43 pubmed publisher
    ..Moreover, we observed an increase of both NOS1 and NOS3 and a slightly increase of NOS2; however, it was not significant...
  10. Seth R, Das S, Dattaroy D, Chandrashekaran V, Alhasson F, Michelotti G, et al. TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity. Free Radic Biol Med. 2017;102:260-273 pubmed publisher
    ..molecular pattern HMGB1 and collagen in diseased Kupffer cells that in turn activate the endothelial NOS (NOS3) to release nitric oxide (NO)...
  11. Syed A, Lahiri S, Mohan D, Valicherla G, Gupta A, Riyazuddin M, et al. Evaluation of anti-hypertensive activity of Ulmus wallichiana extract and fraction in SHR, DOCA-salt- and L-NAME-induced hypertensive rats. J Ethnopharmacol. 2016;193:555-565 pubmed publisher
    ..It also down regulated the expression of Renin, ACE, NOS3 and TGF-?1 at mRNA levels...
  12. Wang Y, Sun Y, Wang Y, Ju Y, Meng D. Virtual screening of active compounds from Artemisia argyi and potential targets against gastric ulcer based on Network pharmacology. Bioorg Chem. 2019;88:102924 pubmed publisher
    ..a2 (PA21B), Sulfotransferase family cytosolic 2b member 1 (ST2B1), Nitric-oxide synthase, endothelial (NOS3), Gastrin (GAST), neutrophil collagenase (MMP-8), Leukotriene A-4 hydrolase (LKHA4), Urease maturation factor HypB (..
  13. Park S, Lim S, Choi H, Bae J. Triazine herbicides inhibit relaxin signaling and disrupt nitric oxide homeostasis. Toxicol Appl Pharmacol. 2016;307:10-18 pubmed publisher
    ..In addition, downstream target genes of the relaxin pathway including nitric oxide (NO) synthase 2 (Nos2), Nos3, matrix metallopeptidase 9 (Mmp9), and vascular endothelial growth factor (Vegf) were downregulated in their ..
  14. Diao Z, Asico L, Villar V, Zheng X, Cuevas S, Armando I, et al. Increased renal oxidative stress in salt-sensitive human GRK4γ486V transgenic mice. Free Radic Biol Med. 2017;106:80-90 pubmed publisher
    ..Renal SOD activity, superoxide production, and NOS3 protein were similar in two strains on normal salt diet...
  15. Sever A, Sever M, Vidovic T, Lojo N, Kolenc D, Vuletic L, et al. Stable gastric pentadecapeptide BPC 157 in the therapy of the rats with bile duct ligation. Eur J Pharmacol. 2019;847:130-142 pubmed publisher
    ..As the end-result appear normalized MDA- and NO-tissue values, next to Western blot of NOS2 and NOS3 in the liver tissue, and decreased IL-6, TNF-α, IL-1β levels in liver tissue...
  16. Khan F, Pandian V, Ramraj S, Aravindan S, Herman T, Aravindan N. Reorganization of metastamiRs in the evolution of metastatic aggressive neuroblastoma cells. BMC Genomics. 2015;16:501 pubmed publisher
    ..FOSB, FRA, GRB10, GSK3β, IL1α, JUND, kRAS, KRTAP1, MCP1, MEGF10, MMP2, MMP3, MMP9, MMP10, MTA2, MYB, cMYC, NF2, NOS3, P21, pP38, PTPN3, CLEAVED PARP, PKC, SDF-1β, SEMA3D, SELE, STAT3, TLR3, TNFα, TNFR1, and VEGF in aggressive ..
  17. Schemmer J, Araúzo Bravo M, Haas N, Schäfer S, Weber S, Becker A, et al. Transcription factor TFAP2C regulates major programs required for murine fetal germ cell maintenance and haploinsufficiency predisposes to teratomas in male mice. PLoS ONE. 2013;8:e71113 pubmed publisher
    ..analyses demonstrated binding of TFAP2C to regulatory regions of deregulated genes (Sfrp1, Dmrt1, Nanos3, c-Kit, Cdk6, Cdkn1a, Fgf4, Klf4, Dnmt3b and Dnmt3l) suggesting that these genes are direct transcriptional ..
  18. Wheatley W, Kohan D. Role for reactive oxygen species in flow-stimulated inner medullary collecting duct endothelin-1 production. Am J Physiol Renal Physiol. 2017;313:F514-F521 pubmed publisher
    ..ester (l-NAME)] reduced the ET-1 flow response; however, pharmacological inhibition of NOS1 or NOS2, inhibition of NOS3 siRNA, inhibition of arginase inhibition, removal of media l-Arg, or inhibition of NO-dependent signaling pathways (..
  19. De Keuckelaere E, Hulpiau P, Saeys Y, Berx G, van Roy F. Nanos genes and their role in development and beyond. Cell Mol Life Sci. 2018;75:1929-1946 pubmed publisher
    ..An inverse correlation between the expression levels of human Nanos1 and Nanos3 and E-cadherin was observed in several cancer cell lines...
  20. Alam A, Mukhopadhyay N, Ning Y, Reshko L, Cardnell R, Alam O, et al. A Preliminary Study on Racial Differences in HMOX1, NFE2L2, and TGFβ1 Gene Polymorphisms and Radiation-Induced Late Normal Tissue Toxicity. Int J Radiat Oncol Biol Phys. 2015;93:436-43 pubmed publisher
    ..modulate the expression of 4 genes involved in inflammation and fibrosis and response to radiation (HMOX1, NFE2L2, NOS3, and TGFβ1)...
  21. Córdoba E, Abba M, Lacunza E, Fernánde E, Güerci A. Polymorphic Variants in Oxidative Stress Genes and Acute Toxicity in Breast Cancer Patients Receiving Radiotherapy. Cancer Res Treat. 2016;48:948-54 pubmed publisher
    ..DNA was extracted from blood and buccal swab samples. SNPs were genotyped for GSTP1, GSTA1, SOD2, and NOS3 genes by polymerase chain reaction-based restriction fragment length polymorphism...
  22. Kobayashi Y, Yamamoto Y, Kageyama S, Hirayama H, Kimura K, Okuda K. Regulation of bovine oviductal NO synthesis by follicular steroids and prostaglandins. Reproduction. 2016;151:577-87 pubmed publisher
    ..Endothelial NOS (NOS3) mRNA expressions in either the ampulla or the isthmus did not change during the estrous cycle...
  23. Raźny U, WÄ…tor Å, Polus A, Kieć Wilk B, Wan Y, Dyduch G, et al. Modulatory effect of high saturated fat diet-induced metabolic disturbances on angiogenic response in hepatocyte RXRα knockout mice. Pharmacol Rep. 2010;62:1078-89 pubmed
    ..The microarray studies revealed that HF diet down-regulated genes related to angiogenesis (Nos3, Kdr) and up-regulated genes connected with apoptosis (activators of caspase 3, proapoptotic genes Bcl2) and ..
  24. Cole P, Finkelstein Y, Stevenson K, Blonquist T, Vijayanathan V, Silverman L, et al. Polymorphisms in Genes Related to Oxidative Stress Are Associated With Inferior Cognitive Function After Therapy for Childhood Acute Lymphoblastic Leukemia. J Clin Oncol. 2015;33:2205-11 pubmed publisher
    ..outcomes were associated with polymorphisms in three genes related to oxidative stress and/or neuroinflammation: NOS3 (IQ, Q = 0.008; Vocabulary Q = 0.011; Matrix Reasoning Q = 0.008), SLCO2A1 (IQ Q = 0.043; Digit Span Q = 0...
  25. Bass C, Redmer D, Kaminski S, Grazul Bilska A. Luteal function during the estrous cycle in arginine-treated ewes fed different planes of nutrition. Reproduction. 2017;153:253-265 pubmed publisher
    ..demonstrated that: (1) nutritional plane affected ovulation rates, luteal vascularity, cell proliferation and NOS3, GUCY1B3, vascular endothelial growth factor (VEGF) and VEGFR2 mRNA expression, (2) Arg affected luteal vascularity,..
  26. Idris Khodja N, Ouerd S, Mian M, Gornitsky J, Barhoumi T, Paradis P, et al. Endothelin-1 Overexpression Exaggerates Diabetes-Induced Endothelial Dysfunction by Altering Oxidative Stress. Am J Hypertens. 2016;29:1245-1251 pubmed publisher
    ..7-fold in eET-1 ( P < 0.05). Diabetes reduced endothelial nitric oxide synthase (eNOS, Nos3 ) expression in eET-1 by 31% ( P < 0.05) but not in WT. Induction of diabetes caused a 52% ( P < 0...
  27. Dugmonits K, Ferencz A, Zahorán S, Lázár R, Talapka P, Orvos H, et al. Elevated levels of macromolecular damage are correlated with increased nitric oxide synthase expression in erythrocytes isolated from twin neonates. Br J Haematol. 2016;174:932-41 pubmed publisher
    ..redox status of neonatal human red blood cells (RBCs) and evaluate the role of endothelial nitric oxide synthase (NOS3) - expressing RBCs in the generation of oxidative stress...
  28. Español A, Salem A, Rojo D, Sales M. Participation of non-neuronal muscarinic receptors in the effect of carbachol with paclitaxel on human breast adenocarcinoma cells. Roles of nitric oxide synthase and arginase. Int Immunopharmacol. 2015;29:87-92 pubmed publisher
    ..The combination also increased nitric oxide production by NOS1 and NOS3 via mAChR activation, concomitantly with an up-regulation of NOS3 expression...
  29. Yamagata K, Suzuki S, Tagami M. Docosahexaenoic acid prevented tumor necrosis factor alpha-induced endothelial dysfunction and senescence. Prostaglandins Leukot Essent Fatty Acids. 2016;104:11-8 pubmed publisher
    ..DHA reversed the TNF-α-mediated reduction of endothelial nitric oxide synthase (NOS3) gene expression. TNF-α-mediated upregulation of these genes was inhibited by allopurinol and apocynin...
  30. Zhong F, Mallipattu S, Estrada C, Menon M, Salem F, Jain M, et al. Reduced Krüppel-Like Factor 2 Aggravates Glomerular Endothelial Cell Injury and Kidney Disease in Mice with Unilateral Nephrectomy. Am J Pathol. 2016;186:2021-2031 pubmed publisher
    ..Expression of endothelial nitric oxide synthase (official name Nos3), a known transcriptional target gene of KLF2, was significantly reduced and dysregulation of other endothelial ..
  31. Panula S, Reda A, Stukenborg J, Ramathal C, Sukhwani M, Albalushi H, et al. Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells. PLoS ONE. 2016;11:e0165268 pubmed publisher
    ..Here, we studied NANOS3 and DAZL, which have critical roles in germ cell development in several species, via their over expression in ..
  32. Shi X, Xie X, Jia Y, Li S. Maternal genetic polymorphisms and unexplained recurrent miscarriage: a systematic review and meta-analysis. Clin Genet. 2017;91:265-284 pubmed publisher
    ..findings suggest that genetic variants of HLA-G, IFNG, TNF, IL-6, IL-10, FII, FV, FXIII, ITGB3, MTR, MTHFR, PAI-1, NOS3, KDR, TP53, VEGFA, CYP17, CYP1A1, CYP2D6, ANXA5, and XCI may serve as biological markers of RM...
  33. Chen F, Li Y, Yang L, Zhong C, Zhuang Z. Association of NOS2 and NOS3 gene polymorphisms with susceptibility to type 2 diabetes mellitus and diabetic nephropathy in the Chinese Han population. IUBMB Life. 2016;68:516-25 pubmed publisher
    Inducible nitric oxide synthase (NOS2) and endothelial nitric oxide synthase (NOS3) gene play important roles in the susceptibility to type 2 diabetes mellitus (T2DM)...
  34. Bielecka Dabrowa A, Sakowicz A, Misztal M, von Haehling S, Ahmed A, Pietrucha T, et al. Differences in biochemical and genetic biomarkers in patients with heart failure of various etiologies. Int J Cardiol. 2016;221:1073-80 pubmed publisher
    ..biomarkers, echocardiographic examinations and functional polymorphisms selected from six candidate genes: CYP27B1, NOS3, IL-6, TGF beta, TNF alpha, and PPAR gamma...
  35. Goto R, Saito T, Kawakami Y, Kitauchi T, Takagi M, Todo T, et al. Visualization of primordial germ cells in the fertilized pelagic eggs of the barfin flounder Verasper moseri. Int J Dev Biol. 2015;59:465-70 pubmed publisher
    ..from the fusion product of a fluorescent protein gene attached to the 3' untranslated region (3'UTR) of zebrafish nanos3 (zf-nos3)...
  36. Dargis N, Lamontagne M, Gaudreault N, Sbarra L, Henry C, Pibarot P, et al. Identification of Gender-Specific Genetic Variants in Patients With Bicuspid Aortic Valve. Am J Cardiol. 2016;117:420-6 pubmed publisher
    ..Nine genes previously associated with BAV (NOTCH1, AXIN1, EGFR, ENG, GATA5, NKX2-5, NOS3, PDIA2, and TGFBR2) were sequenced in 48 patients with BAV using the Ion Torrent Personal Genome Machine...
  37. Takahashi E, Shimizu Y, Urushibata H, Kawakami Y, Arai K, Yamaha E. Migration behavior of PGCs and asymmetrical gonad formation in pond smelt Hypomesus nipponensis. Int J Dev Biol. 2017;61:397-405 pubmed publisher
    ..Third, the migration route of PGCs was tracked by microinjection of GFP-nos3 3' UTR mRNA and visualization of PGCs by green fluorescent protein...
  38. Janić M, Lunder M, France Štiglic A, Jerin A, Skitek M, Cerne D, et al. Sub-therapeutic doses of fluvastatin and valsartan are more effective than therapeutic doses in providing beneficial cardiovascular pleiotropic effects in rats: A proof of concept study. Vascul Pharmacol. 2017;99:45-52 pubmed publisher
    ..Furthermore, nitric oxide synthase 3 (NOS3) and endothelin receptor type A (EDNRA) genes expression increased, but only in both combination groups and without ..
  39. Kowalski T, Fraga L, Tovo Rodrigues L, Sanseverino M, Hutz M, Schuler Faccini L, et al. New Findings in eNOS gene and Thalidomide Embryopathy Suggest pre-transcriptional effect variants as susceptibility factors. Sci Rep. 2016;6:23404 pubmed publisher
    ..of alleles that impair the pro-angiogenic mechanisms of endothelial nitric oxide synthase (eNOS), coded by the NOS3 gene...
  40. Guha P, Kaptan E, Gade P, Kalvakolanu D, Ahmed H. Tunicamycin induced endoplasmic reticulum stress promotes apoptosis of prostate cancer cells by activating mTORC1. Oncotarget. 2017;8:68191-68207 pubmed publisher
    ..Among several induced genes, the expression of eNOS (NOS3) gene was remarkably high. The increased expression of eNOS activates mTORC1 through RagC...
  41. Oliveira Paula G, Luizon M, Lacchini R, Fontana V, Silva P, Biagi C, et al. Gene-Gene Interactions Among PRKCA, NOS3 and BDKRB2 Polymorphisms Affect the Antihypertensive Effects of Enalapril. Basic Clin Pharmacol Toxicol. 2017;120:284-291 pubmed publisher
    ..Multi-factor dimensionality reduction was used to characterize interactions among PRKCA, NOS3 (nitric oxide synthase 3) and BDKRB2 (bradykinin receptor B2) polymorphisms...
  42. Matsha T, Pheiffer C, Mutize T, Erasmus R, Kengne A. Glucose Tolerance, MTHFR C677T and NOS3 G894T Polymorphisms, and Global DNA Methylation in Mixed Ancestry African Individuals. J Diabetes Res. 2016;2016:8738072 pubmed
    ..global DNA methylation and investigate the relationship with diabetes status and polymorphisms in MTHFR C677T and NOS3 G894T genes in mixed ancestry subjects from South Africa...
  43. Persoon S, Paulus M, Hirt S, Jungbauer C, Dietl A, Luchner A, et al. Cardiac unloading by LVAD support differentially influences components of the cGMP-PKG signaling pathway in ischemic and dilated cardiomyopathy. Heart Vessels. 2018;33:948-957 pubmed publisher
    ..chain reaction (ANP; BNP; natriuretic peptide receptor A, NPR-A; natriuretic peptide receptor C, NPR-C; neprilysin; NOS3; soluble guanylyl cyclase, sGC; PDE5; cGMP-dependent protein kinase G, PKG) and enzyme-linked immunosorbent assay (..
  44. Yao Y, Fang Z, Yang S, Zhao H, Chen Y, Jin Y, et al. Evaluation of genetic effect of NOS3 and G×E interaction on the variability of serum bilirubin in a Han Chinese population. Nitric Oxide. 2017;70:25-30 pubmed publisher
    ..to the generation and functional exertion of endothelial nitric oxide synthase (eNOS) whilst the genetic effect of NOS3 on bilirubin variability was rarely reported...
  45. Leonardo D, Albuquerque D, Lanaro C, Baptista L, Cecatti J, Surita F, et al. Association of Nitric Oxide Synthase and Matrix Metalloprotease Single Nucleotide Polymorphisms with Preeclampsia and Its Complications. PLoS ONE. 2015;10:e0136693 pubmed publisher
    ..To investigate the association of single nucleotide polymorphisms (SNPs) in NOS3 (G894T, T-786C, and a variable number of tandem repetitions VNTR in intron 4), MMP2 (C-1306T), and MMP9 (C-1562T) ..
  46. Zhao J, Zhang W, Shen L, Yang X, Liu Y, Gai Z. Association of the ACE, GSTM1, IL-6, NOS3, and CYP1A1 polymorphisms with susceptibility of mycoplasma pneumoniae pneumonia in Chinese children. Medicine (Baltimore). 2017;96:e6642 pubmed publisher
    ..association of 5 functional genes and the risks of MPP, including ACE (rs4340), GSTM1 (Ins/del), IL-6 (rs1800795), NOS3 (rs1799983), and CYP1A1 (rs2606345) in a total of 715 subjects (415 cases, 300 controls) by using tetra-primer ..
  47. Saracyn M, Czarzasta K, Brytan M, Murawski P, Lewicki S, Zabkowski T, et al. Role of Nitric Oxide Pathway in Development and Progression of Chronic Kidney Disease in Rats Sensitive and Resistant to its Occurrence in an Experimental Model of 5/6 Nephrectomy. Med Sci Monit. 2017;23:4865-4873 pubmed
    ..5/6 nephrectomy resulted in reduction of NOS2 in both strains and NOS3 in WR...
  48. Nasr H, Dimassi S, M hadhbi R, Debbabi H, Kortas M, Tabka Z, et al. Functional G894T (rs1799983) polymorphism and intron-4 VNTR variant of nitric oxide synthase (NOS3) gene are susceptibility biomarkers of obesity among Tunisians. Obes Res Clin Pract. 2016;10:465-75 pubmed publisher
    The endothelial nitric oxide synthase (NOS3) has been shown to play a role in the modulation of lipolysis...
  49. Shahid S, Shabana -, Cooper J, Beaney K, Li K, Rehman A, et al. Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants. Atherosclerosis. 2017;258:1-7 pubmed publisher
    ..625 (405 cases and 220 controls) subjects were genotyped for variants, NOS3 rs1799983, SMAD3 rs17228212, APOB rs1042031, LPA rs3798220, LPA rs10455872, SORT1 rs646776, APOE rs429358, GLUL ..
  50. Bushueva O, Stetskaya T, Korogodina G, Ivanov V, Polonikov A. [GENDER-SPECIFIC DIFFERENCES OF ENDOTHELIAL NITRIC OXIDE SYNTHASE E298D POLYMORPHISM AND THE RISK OF STROKE]. Klin Med (Mosk). 2015;93:34-40 pubmed
    ..aimed to study the relationship between frequent polymorphisms -786T > C of endothelial nitric oxide synthase (NOS3) gene E298D and the risk of stroke in men and women...
  51. Nasibullin T, Timasheva Y, Sadikova R, Tuktarova I, Erdman V, Nikolaeva I, et al. Genotype/allelic combinations as potential predictors of myocardial infarction. Mol Biol Rep. 2016;43:11-6 pubmed publisher
    ..PECAM1 (rs668, V125L), VEGFA (rs35569394, -2549(18)I/D), CCL2 (rs1024611, -2518A > G), NOS3 (rs1799983, E298D), and DDAH1 (rs669173, c...
  52. Krajinovic M, Elbared J, Drouin S, Bertout L, Rezgui A, Ansari M, et al. Polymorphisms of ABCC5 and NOS3 genes influence doxorubicin cardiotoxicity in survivors of childhood acute lymphoblastic leukemia. Pharmacogenomics J. 2016;16:530-535 pubmed publisher
    ..modulating effect of two variants: A-1629 T in ABCC5, an ATP-binding cassette transporter, and G894T in the NOS3 endothelial nitric oxide synthase gene...
  53. Han K, Chen S, Cai M, Jiang Y, Zhang Z, Wang Y. Nanos3 not nanos1 and nanos2 is a germ cell marker gene in large yellow croaker during embryogenesis. Comp Biochem Physiol B Biochem Mol Biol. 2018;218:13-22 pubmed publisher
    ..Furthermore, we preliminarily analyzed the migration route of PGCs in embryos of L. crocea. In short, this study laid the foundation for studies on specification and development of germ cell from L. crocea during embryogenesis. ..
  54. Singh S, Vennila J, Snijesh V, George G, Sunny C. Implying Analytic Measures for Unravelling Rheumatoid Arthritis Significant Proteins Through Drug-Target Interaction. Interdiscip Sci. 2016;8:122-31 pubmed publisher
    ..from the important hubs which resulted into FOS, KNG1, PTGDS, HSP90AA1, REN, POMC, FCER1G, IL6, ICAM1, SGK1, NOS3 and PLA2G4A...
  55. Bushueva O, Stetskaya T, Korogodina T, Ivanov V, Polonikov A. [The combined effect of E298D polymorphism of the endothelial nitric oxide synthase gene and smoking on the risk of cerebral stroke]. Genetika. 2015;51:256-62 pubmed
    ..was to investigate the association of--86T>C and E298D polymorphisms of the endothelial nitric oxide synthase(NOS3) gene with the risk of ce-ebral stroke (CS) in Russian inhabitants of Central Russia, as well as to evaluate the ..
  56. Rong S, Tang F, Chu W, Ma L, Yam J, Tang S, et al. Genetic Associations of Primary Angle-Closure Disease: A Systematic Review and Meta-analysis. Ophthalmology. 2016;123:1211-21 pubmed publisher
    ..66; p = 0.012; rs3814762-g, or, 1.40; p = 0.0090), mmp9 (rs3918249-c, or, 1.35; p = 0.034), nos3 (rs7830-a, or, 0.80; p = 0.036), plekha7 (rs11024102-g, or, 1.24; p = 8...
  57. Hefler L, Tempfer C, Moreno R, O Brien W, Gregg A. Endothelial-derived nitric oxide and angiotensinogen: blood pressure and metabolism during mouse pregnancy. Am J Physiol Regul Integr Comp Physiol. 2001;280:R174-82 pubmed
    ..These included mice with a null mutation in the endothelial NOS (eNOS) gene (Nos3(-/-)), four copies of the angiotensinogen gene (Agt(2/2)), and mutations in both genes [four copies of Agt and ..
  58. Liu X, Hernandez N, Kisselev S, Floratos A, Sawle A, Ionita Laza I, et al. Identification of candidate genes for familial early-onset essential tremor. Eur J Hum Genet. 2016;24:1009-15 pubmed publisher
    ..independent families, we identified variants predicted to affect function in the nitric oxide (NO) synthase 3 gene (NOS3) that cosegregated with disease...
  59. Oliveira Paula G, Lacchini R, Tanus Santos J. Clinical and pharmacogenetic impact of endothelial nitric oxide synthase polymorphisms on cardiovascular diseases. Nitric Oxide. 2017;63:39-51 pubmed publisher
    Nitric oxide (NO) is a vasoactive substance synthesized from l-arginine by neuronal (NOS1), endothelial (NOS3), and inducible (NOS2) nitric oxide synthases...
  60. Zhao G, Li Q, Lu H. Association between NOS3 genetic variants and coronary artery disease in the Han population. Genet Mol Res. 2016;15: pubmed publisher
    The enzyme endothelial nitric oxide synthase (NOS3) is an important mediator of atherosclerotic disease and is associated with coronary artery disease (CAD)...
  61. Koenig S, Bosse K, Majumdar U, Bonachea E, Radtke F, Garg V. Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract. J Am Heart Assoc. 2016;5: pubmed publisher
    ..cusps and associated stenosis and regurgitation, in Notch1-haploinsufficient adult mice backcrossed into a Nos3-null background...
  62. Landers J, Esch T. Sport physiology, dopamine and nitric oxide - Some speculations and hypothesis generation. Med Hypotheses. 2015;85:905-9 pubmed publisher
    ..have their negative feedback system overwhelmed, were it not that many of them carry the C allele of the NOS3-786T/C polymorphism. Then, even very high DA would not result in so much NO as to shut the system down...
  63. Huang R, He Y, Sun B, Liu B. Bioinformatic Analysis Identifies Three Potentially Key Differentially Expressed Genes in Peripheral Blood Mononuclear Cells of Patients with Takayasu's Arteritis. Cell J. 2018;19:647-653 pubmed publisher
    ..However, NOS2 was not significantly altered in the analyzed microarray dataset. Nevertheless, NOS3 was a significantly down-regulated gene and was involved in the platelet activation pathway...
  64. Tesch G, Ma F, Han Y, Liles J, Breckenridge D, Nikolic Paterson D. ASK1 Inhibitor Halts Progression of Diabetic Nephropathy in Nos3-Deficient Mice. Diabetes. 2015;64:3903-13 pubmed publisher
    ..Diabetes was induced in hypertensive endothelial nitric oxide synthase (Nos3)-deficient mice by five low-dose streptozotocin (STZ) injections...
  65. Cheng D, Murtaza G, Ma S, Li L, Li X, Tian F, et al. In Silico Prediction of the Anti-Depression Mechanism of a Herbal Formula (Tiansi Liquid) Containing Morinda officinalis and Cuscuta chinensis. Molecules. 2017;22: pubmed publisher
    ..A significant number of protein targets such as IL10, MAPK1, PTGS2, AKT1, APOE, PPARA, MAPK1, MIF, NOS3 and TNF-α were found to be involved in the functioning of Tiansi Liquid against depression...
  66. Chen M, Tang W, Hou L, Liu R, Dong Z, Han X, et al. Tumor Necrosis Factor (TNF) -308G>A, Nitric Oxide Synthase 3 (NOS3) +894G>T Polymorphisms and Migraine Risk: A Meta-Analysis. PLoS ONE. 2015;10:e0129372 pubmed publisher
    ..have been reported on the association between tumor necrosis factor (TNF) -308G>A and nitric oxide synthase 3 (NOS3) +894G>T polymorphisms and migraine...
  67. Sousa B, Nishi M, Santos M, Brito V, Domenice S, Mendonca B. Mutation analysis of NANOS3 in Brazilian women with primary ovarian failure. Clinics (Sao Paulo). 2016;71:695-698 pubmed publisher
    ..The aim of this study was to search for mutations in NANOS3, a gene that was recently related to the etiology of primary ovarian failure, in a group of Brazilian women...
  68. Fuchs O, Gorlanova O, Latzin P, Schmidt A, Schieck M, Toncheva A, et al. 6q12 and 11p14 variants are associated with postnatal exhaled nitric oxide levels and respiratory symptoms. J Allergy Clin Immunol. 2017;140:1015-1023 pubmed publisher
    ..6 × 10-6), which is located at 11p14, potentially affecting nitric oxide synthase 3 (NOS3) expression, as shown by means of in vitro functional analyses...
  69. Wobst J, Schunkert H, Kessler T. Genetic alterations in the NO-cGMP pathway and cardiovascular risk. Nitric Oxide. 2018;76:105-112 pubmed publisher
    ..e., NOS3, PDE3A, PDE5A, and MRVI1, respectively, were likewise identified as CAD risk genes...
  70. Kahraman C, Tasdemir S, Sahin I, Marzioglu Ozdemir E, Yaralı O, Ziypak T, et al. The Relationship Between Endothelial Nitric Oxide Synthase Gene (NOS3) Polymorphisms, NOS3 Expression, and Varicocele. Genet Test Mol Biomarkers. 2016;20:191-6 pubmed publisher
    ..NO), which has a role on varicocele pathophysiology, is synthesized by endothelial nitric oxide synthase gene (NOS3)...
  71. Kobayashi M, Tani Matsuhana S, Ohkawa Y, Sakamoto H, Inoue K. DND protein functions as a translation repressor during zebrafish embryogenesis. Biochem Biophys Res Commun. 2017;484:235-240 pubmed publisher
    ..protein, DND, has been reported to relieve the miR-430-mediated repression of some germ plasm mRNAs such as nanos3 and tdrd7 in primordial germ cells (PGCs)...
  72. Farzan V, Markelov M, Skoblov A, Shipulin G, Zatsepin T. Specificity of SNP detection with molecular beacons is improved by stem and loop separation with spacers. Analyst. 2017;142:945-950 pubmed publisher
    ..We demonstrated the applicability of such modified MBs for the discrimination of common Factor V, NOS3 and ADRB2 SNPs in model plasmids and in clinical samples...
  73. Cacabelos R, Meyyazhagan A, Carril J, Cacabelos P, Teijido Ã. Pharmacogenetics of Vascular Risk Factors in Alzheimer's Disease. J Pers Med. 2018;8: pubmed publisher
    ..Furthermore, APOE, NOS3, ACE, AGT, and CYP variants influence the therapeutic response to hypotensive drugs in AD ..
  74. Saleh A, Stathopoulou M, Dadé S, Ndiaye N, Azimi Nezhad M, Murray H, et al. Angiogenesis related genes NOS3, CD14, MMP3 and IL4R are associated to VEGF gene expression and circulating levels in healthy adults. BMC Med Genet. 2015;16:90 pubmed publisher
    ..The aim was to assess the genetic connections between the angiogenesis-related NOS3, CD14, MMP3, IL4R, IL4 genes and VEGF expression and plasma levels...
  75. Peña C, Gonzalez R, López Grueso M, Antonio Bárcena J. Redox Regulation Of Metabolic And Signaling Pathways By Thioredoxin And Glutaredoxin In Nitric Oxide Treated Hepatoblastoma Cells. Redox Biol. 2015;5:418 pubmed publisher
    ..Overexpression of NOS3 increased the levels and activities of proteins of the redoxin systems, Trx1, Grx1, TrxR1 and TxnIP, and the levels ..