NAB2

Summary

Gene Symbol: NAB2
Description: NGFI-A binding protein 2
Alias: MADER, NGFI-A-binding protein 2, EGR1 binding protein 2, melanoma-associated delayed early response protein
Species: human
Products:     NAB2

Top Publications

  1. Kirsch K, Korradi Y, Johnson J. Mader: a novel nuclear protein over expressed in human melanomas. Oncogene. 1996;12:963-71 pubmed
    b>Mader is a novel delayed early response gene encoding a nuclear protein. Upregulation of the Mader 2...
  2. Lucerna M, Mechtcheriakova D, Kadl A, Schabbauer G, Schäfer R, Gruber F, et al. NAB2, a corepressor of EGR-1, inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells. J Biol Chem. 2003;278:11433-40 pubmed
    In this study we have investigated the role of a specific corepressor of EGR-1, NAB2, to down-regulate vascular endothelial growth factor (VEGF)-induced gene expression in endothelial cells and to inhibit angiogenesis...
  3. Bhattacharyya S, Wei J, Melichian D, Milbrandt J, Takehara K, Varga J. The transcriptional cofactor nab2 is induced by tgf-Beta and suppresses fibroblast activation: physiological roles and impaired expression in scleroderma. PLoS ONE. 2009;4:e7620 pubmed publisher
    ..NGF1-A-binding protein 2 (Nab2) is a conserved transcriptional cofactor that directly binds to Egr-1 and positively or negatively modulates Egr-1 ..
  4. Robinson D, Wu Y, Kalyana Sundaram S, Cao X, Lonigro R, Sung Y, et al. Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. Nat Genet. 2013;45:180-5 pubmed publisher
    ..A gene fusion of the transcriptional repressor NAB2 with the transcriptional activator STAT6 was detected...
  5. Chmielecki J, Crago A, Rosenberg M, O Connor R, Walker S, Ambrogio L, et al. Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors. Nat Genet. 2013;45:131-2 pubmed publisher
    Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs...
  6. Schweizer L, Koelsche C, Sahm F, Piro R, Capper D, Reuss D, et al. Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein. Acta Neuropathol. 2013;125:651-8 pubmed publisher
    ..Recent detection of frequent NAB2-STAT6 fusions in both, HPC and SFT, provided additional support for this view...
  7. Svaren J, Sevetson B, Apel E, Zimonjic D, Popescu N, Milbrandt J. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. Mol Cell Biol. 1996;16:3545-53 pubmed
    ..We have isolated and characterized another corepressor, NAB2, which is highly related to NAB1 within two discrete domains...
  8. Svaren J, Sevetson B, Golda T, Stanton J, Swirnoff A, Milbrandt J. Novel mutants of NAB corepressors enhance activation by Egr transactivators. EMBO J. 1998;17:6010-9 pubmed
    The NGFI-A binding corepressors NAB1 and NAB2 interact with a conserved domain (R1 domain) within the Egr1/NGFI-A and Egr2/Krox20 transactivators, and repress the transcription of Egr target promoters...
  9. Abdulkadir S, Carbone J, Naughton C, Humphrey P, Catalona W, Milbrandt J. Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma. Hum Pathol. 2001;32:935-9 pubmed
    ..In addition, mice lacking the Egr1 gene show a defect in prostate tumorigenesis. NAB2 is a novel corepressor molecule that modulates EGR1 activity and is induced by the same stimuli that induce EGR1...

More Information

Publications112 found, 100 shown here

  1. Srinivasan R, Mager G, Ward R, Mayer J, Svaren J. NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. J Biol Chem. 2006;281:15129-37 pubmed
    ..The NAB1 and NAB2 (NGFI-A/EGR1-binding protein) transcriptional corepressors directly interact with three EGR family members (Egr1/..
  2. Huang S, Huang H. Solitary fibrous tumor: An evolving and unifying entity with unsettled issues. Histol Histopathol. 2019;34:313-334 pubmed publisher
    ..Notably, the recent groundbreaking discovery of the disease-defining NAB2-STAT6 gene fusion, resulting from intrachromosomal inversion involving 12q13...
  3. Pecci Maddalena I, Lopes Andrade C. Redescriptions, Lectotype Designations, New Synonyms and New Geographic Records for the "Tiger" Species of Mycotretus Lacordaire, 1842 (Coleoptera: Erotylidae: Tritomini). Insects. 2018;9: pubmed publisher
    ..multimaculatus Taschenberg, 1870; M. centralis Arrow, 1909; M. tigrinoides Mader, 1942; M. tigripennis Mader, 1942; and M. prioteloides Mader, 1942...
  4. Kakkar A, Sakthivel P, Rajeshwari M, Kairo A, Sharma M. Recurrent Sinonasal CD34-Negative Malignant Solitary Fibrous Tumor Diagnosed on STAT6 Immunohistochemistry and NAB2-STAT6 Fusion. Head Neck Pathol. 2019;: pubmed publisher
    ..One of these is solitary fibrous tumor (SFT), a translocation-associated neoplasm characterized by NAB2-STAT6 gene fusion. Sinonasal SFTs characteristically display CD34 immunopositivity, which aids in diagnosis...
  5. Pacini L, Suffredini S, Ponti D, Coppini R, Frati G, Ragona G, et al. Altered calcium regulation in isolated cardiomyocytes from Egr-1 knock-out mice. Can J Physiol Pharmacol. 2013;91:1135-42 pubmed publisher
    ..Furthermore, genes involved in heart development (GATA-4, TGF-β) and in Egr-1 regulation (Nab1, Nab2) were down regulated in Egr-1(-/-) mice...
  6. Lu C, Alex D, Benayed R, Rosenblum M, Hameed M. Solitary fibrous tumor with neuroendocrine and squamous dedifferentiation: a potential diagnostic pitfall. Hum Pathol. 2018;77:175-180 pubmed publisher
    ..Positive immunohistochemical stains for CD34 and STAT6 and the detection of NAB2-STAT6 fusion supported the diagnosis of dedifferentiated SFT in both cases...
  7. Apra C, Alentorn A, Mokhtari K, Kalamarides M, Sanson M. Pazopanib efficacy in recurrent central nervous system hemangiopericytomas. J Neurooncol. 2018;139:369-372 pubmed publisher
    ..The NAB2-STAT6 gene fusion is the hallmark of these tumors, and upregulates Early Growth Factor, activating several growth ..
  8. Tan N, Sun I, Low S, Kuick C, Chang K, Tan C. A rapidly fatal intracranial anaplastic hemangiopericytoma with de-novo dedifferentiation: emphasis on diagnostic recognition, molecular confirmation and discussion on treatment dilemma. Brain Tumor Pathol. 2019;36:20-26 pubmed publisher
    ..Although it is now known that SFT/HPC is characterized by NAB2-STAT6 gene fusion, the unavailability of targeted therapy against this molecular signature still results in a ..
  9. Gharaee Kermani M, Mehra R, Robinson D, Wei J, Macoska J. Complex cellular composition of solitary fibrous tumor of the prostate. Am J Pathol. 2014;184:732-9 pubmed publisher
    ..Consistent with other recent studies, the prostatic SFTs demonstrated NAB2-STAT6 gene fusions that were also present in the fibroblast, myofibroblast, and smooth muscle cell types of the SFT...
  10. Chen Z, Yue S, Zhou G, Greenfield E, Murakami S. ERK1 and ERK2 regulate chondrocyte terminal differentiation during endochondral bone formation. J Bone Miner Res. 2015;30:765-74 pubmed publisher
    ..promoter, whereas the MEK1-induced activation of the Osteopontin promoter was inhibited by the coexpression of Nab2, an Egr1 and Egr2 co-repressor...
  11. Bezstarosti H, Van Lieshout E, Voskamp L, Kortram K, Obremskey W, McNally M, et al. Insights into treatment and outcome of fracture-related infection: a systematic literature review. Arch Orthop Trauma Surg. 2019;139:61-72 pubmed publisher
    ..A total of nine different classifications were used to guide treatment protocols, of which Cierny and Mader was used most often (36%)...
  12. Fritchie K, Jensch K, Moskalev E, Caron A, Jenkins S, Link M, et al. The impact of histopathology and NAB2-STAT6 fusion subtype in classification and grading of meningeal solitary fibrous tumor/hemangiopericytoma. Acta Neuropathol. 2019;137:307-319 pubmed publisher
    ..A STAT6 immunostain showed nuclear expression in 132 cases. NAB2-STAT6 fusion was detected in 99 of 111 successfully tested tumors (89%) including the single STAT6 immunonegative ..
  13. Guinot G, Adnet S, Shimada K, Underwood C, Siversson M, Ward D, et al. On the need of providing tooth morphology in descriptions of extant elasmobranch species. Zootaxa. 2018;4461:118-126 pubmed publisher
    ..Other remains such as articulated skeletons and teeth are known from the Lower Devonian (ca. 410 Mya: Mader 1986; Miller et al. 2003)...
  14. Petrovic A, Obéric A, Moulin A, Hamedani M. Ocular adnexal (orbital) solitary fibrous tumor: nuclear STAT6 expression and literature review. Graefes Arch Clin Exp Ophthalmol. 2015;253:1609-17 pubmed publisher
    ..To assess the presence of NAB2-STAT6 genes fusion in OA solitary fibrous tumor detected by nuclear overexpression of STAT6...
  15. Yuzawa S, Tanikawa S, Kunibe I, Nishihara H, Nagashima K, Tanaka S. A case of giant cell-rich solitary fibrous tumor in the external auditory canal. Pathol Int. 2016;66:701-705 pubmed publisher
    ..Moreover, both mononuclear spindle cells and multinucleate cells showed nuclear STAT6 positivity, while NAB2-STAT6 fusion gene could not be detected by reverse transcription polymerase chain reaction using formalin-fixed ..
  16. Wu H, Shen J, Yu X, Fu J, Yu S, Sun D, et al. Two stage management of Cierny-Mader type IV chronic osteomyelitis of the long bones. Injury. 2017;48:511-518 pubmed publisher
    Cierny-Mader (C-M) type IV chronic osteomyelitis represents a complex clinical challenge with permeation of extensive bone and soft tissue involvement...
  17. Hosseini M, Allami M, Soroush M, Babaha F, Minooeefar J, Rahimpoor D. Chronic traumatic ankle and foot osteomyelitis: a nationwide case-control study. Mil Med Res. 2018;5:15 pubmed publisher
    ..were categorized according to their risk factors as A, B and C hosts using a modified version of the Cierny and Mader classification system...
  18. Song Z, Yang F, Zhang Y, Fan P, Liu G, Li C, et al. Surgical therapy and next-generation sequencing-based genetic alteration analysis of malignant solitary fibrous tumor of the pleura. Onco Targets Ther. 2018;11:5227-5238 pubmed publisher
    ..KDR) and fms-related tyrosine kinase 1 (FLT1) scored high in pathogenesis but had only a medium frequency; the NAB2-STAT6 fusion appeared to be the dominant genetic alteration in public SFTP samples...
  19. Ma W, Paudel B, Xing Z, Sabath I, Rueda D, Tran E. Recruitment, Duplex Unwinding and Protein-Mediated Inhibition of the Dead-Box RNA Helicase Dbp2 at Actively Transcribed Chromatin. J Mol Biol. 2016;428:1091-1106 pubmed publisher
    ..is required to promote efficient assembly of the co-transcriptionally associated mRNA-binding proteins Yra1, Nab2, and Mex67 onto poly(A)(+)RNA...
  20. Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov D, Brcic L, et al. Stable gastric pentadecapeptide BPC 157-NO-system relation. Curr Pharm Des. 2014;20:1126-35 pubmed
    ..advances healing after severe injuries in various tissues spontaneously unable to heal; stimulates egr-1 and naB2 genes; exhibits high safety (LD1 not achieved))...
  21. Han Y, Zhang Q, Yu X, Han X, Wang H, Xu Y, et al. Immunohistochemical detection of STAT6, CD34, CD99 and BCL-2 for diagnosing solitary fibrous tumors/hemangiopericytomas. Int J Clin Exp Pathol. 2015;8:13166-75 pubmed
    ..Recently, NGFI-A binding protein 2 (NAB2)-signal transducer and the activator of transcription 6 (STAT6) fusion gene were discovered as a hallmark of SFTs/..
  22. Maekawa A, Kohashi K, Yamada Y, Nakamizo A, Yoshimoto K, Mizoguchi M, et al. A case of intracranial solitary fibrous tumor/hemangiopericytoma with dedifferentiated component. Neuropathology. 2015;35:260-5 pubmed publisher
    ..b>NAB2-STAT6 fusion transcripts were detected by reverse transcriptase polymerase chain reaction in both the conventional ..
  23. Tuck A, Tollervey D. A transcriptome-wide atlas of RNP composition reveals diverse classes of mRNAs and lncRNAs. Cell. 2013;154:996-1009 pubmed publisher
    ..The Hrp1 and Nab2 proteins act at this decision point, with dual roles in mRNA cleavage/polyadenylation and lncRNA surveillance...
  24. Lin Y, Seger N, Tsagkozis P, Hesla A, Ghaderi M, Chen Y, et al. Telomerase promoter mutations and copy number alterations in solitary fibrous tumours. J Clin Pathol. 2018;71:832-839 pubmed publisher
    Solitary fibrous tumour (SFT) is an infrequently metastasising mesenchymal tumour defined by the NAB2-STAT6 fusion gene...
  25. Vogels R, Vlenterie M, Versleijen Jonkers Y, Ruijter E, Bekers E, Verdijk M, et al. Solitary fibrous tumor - clinicopathologic, immunohistochemical and molecular analysis of 28 cases. Diagn Pathol. 2014;9:224 pubmed publisher
    ..Recently, a recurrent gene fusion NAB2-STAT6 has been identified as molecular hallmark...
  26. Ichiyanagi O, Ito H, Takai S, Naito S, Kato T, Nagaoka A, et al. A GRIA2 and PAX8-positive renal solitary fibrous tumor with NAB2-STAT6 gene fusion. Diagn Pathol. 2015;10:155 pubmed publisher
    ..IHC revealed that the tumor diffusely expressed CD34, CD99, Bcl2, PAX8, NAB2, STAT6, and GRIA2. The tumor stained negatively for desmin, S-100, c-Kit, CK-AE1/AE3, CDK4 and MDM2...
  27. Ronchi A, Cozzolino I, Zito Marino F, Accardo M, Montella M, Panarese I, et al. Extrapleural solitary fibrous tumor: A distinct entity from pleural solitary fibrous tumor. An update on clinical, molecular and diagnostic features. Ann Diagn Pathol. 2018;34:142-150 pubmed publisher
    ..Although the etiology of the neoplasm remains largely unknown, the pathogenesis seems to be related to an NAB2-STAT6 fusion gene due to paracentric inversion on chromosome 12q13...
  28. Welch T, LaPatra S. Yersinia ruckeri lipopolysaccharide is necessary and sufficient for eliciting a protective immune response in rainbow trout (Oncorhynchus mykiss, Walbaum). Fish Shellfish Immunol. 2016;49:420-6 pubmed publisher
    ..ruckeri. Mutation of the nab2 gene, a nonulosonic acid biosynthesis gene (nab gene), resulted in production of severely truncated forms of LPS...
  29. Magro G, Spadola S, Motta F, Palazzo J, Catalano F, Vecchio G, et al. STAT6 expression in spindle cell lesions of the breast: An immunohistochemical study of 48 cases. Pathol Res Pract. 2018;214:1544-1549 pubmed publisher
    ..against the STAT6 C-terminal, are being used in paraffin-embedded tissues as a surrogate for identifying the NAB2-STA6 fusion gene which is considered a specific molecular marker for solitary fibrous tumor...
  30. Burger L, Haisenleder D, Aylor K, Marshall J. Regulation of Lhb and Egr1 gene expression by GNRH pulses in rat pituitaries is both c-Jun N-terminal kinase (JNK)- and extracellular signal-regulated kinase (ERK)-dependent. Biol Reprod. 2009;81:1206-15 pubmed publisher
    ..We examined GNRH regulation of EGR1 and its two corepressors, Ngfi-A-binding proteins 1 and 2 (NAB1 and NAB2), both in vivo and in cultured rat pituitary cells...
  31. Ouladan S, Trautmann M, Orouji E, Hartmann W, Huss S, Büttner R, et al. Differential diagnosis of solitary fibrous tumors: A study of 454 soft tissue tumors indicating the diagnostic value of nuclear STAT6 relocation and ALDH1 expression combined with in situ proximity ligation assay. Int J Oncol. 2015;46:2595-605 pubmed publisher
    ..We investigated the expression of STAT6, NAB2, ALDH1, GRIA2 and IGF2 in 454 comprehensive soft tissue tumors, comprising formalin-fixed paraffin-embedded (FFPE) ..
  32. Thway K, Ng W, Noujaim J, Jones R, Fisher C. The Current Status of Solitary Fibrous Tumor: Diagnostic Features, Variants, and Genetics. Int J Surg Pathol. 2016;24:281-92 pubmed publisher
    ..However, it is now recognized that SFT is a translocation-associated neoplasm, consistently associated with NAB2-STAT6 gene fusions arising from recurrent intrachromosomal rearrangements on chromosome 12q, and this translocation ..
  33. Saynak M, Veeramachaneni N, Hubbs J, OkumuÅŸ D, Marks L. Solitary Fibrous Tumors of Chest: Another Look with the Oncologic Perspective. Balkan Med J. 2017;34:188-199 pubmed publisher
    ..The signature marker of solitary fibrous tumor is the presence of the NAB2-STAT6 fusion that can be reliably detected with a STAT6 antibody...
  34. Skelley P, Xu G, Tang W, Lindström A, Marler T, Khuraijam J, et al. Review of Cycadophila Xu, Tang & Skelley (Coleoptera: Erotylidae: Pharaxonothinae) inhabiting Cycas (Cycadaceae) in Asia, with descriptions of a new subgenus and thirteen new species. Zootaxa. 2017;4267:1-63 pubmed publisher
    ..C.) vittata (Arrow) new combination, C. (C.) discimaculata (Mader) new combination, C. (C.) intermedia (Chûjô) new combination, and C. (C.) lata (Grouvelle) new combination...
  35. Allan P, Stevens P, Chadwick P, Teubner A, Abraham A, Carlson G, et al. Osteomyelitis in adult patients on long-term parenteral nutrition: 2745 patient-years of experience in a national referral centre. Clin Nutr. 2016;35:1135-9 pubmed publisher
    ..Patients with AIF had more severe OM compared to those with CIF, according to the Cierny Mader classification. All patients received at least 6 weeks antimicrobial chemotherapy...
  36. Agaimy A, Haller F, Hartmann A. [Sinonasal tumors : News from the WHO with special reference to mesenchymal entities]. Pathologe. 2018;39:18-26 pubmed publisher
    ..Recognition of CTNNB1 mutations and STAT6/NAB2 gene fusions as defining genetic markers for sinonasal hemangio‑/glomangiopericytoma and solitary fibrous ..
  37. Kouba E, Simper N, Chen S, Williamson S, Grignon D, Eble J, et al. Solitary fibrous tumour of the genitourinary tract: a clinicopathological study of 11 cases and their association with the NAB2-STAT6 fusion gene. J Clin Pathol. 2017;70:508-514 pubmed publisher
    ..features and clinical outcomes of the genitourinary tract solitary fibrous tumours, incorporating NAB2-STAT6 gene fusion status...
  38. Saroufim M, Bensidoun P, Raymond P, Rahman S, Krause M, Oeffinger M, et al. The nuclear basket mediates perinuclear mRNA scanning in budding yeast. J Cell Biol. 2015;211:1131-40 pubmed publisher
    ..Deletion or mutation of the nuclear basket proteins MLP1/2 or the mRNA binding protein Nab2 changes the scanning behavior of mRNPs at the nuclear periphery, shortens residency time at nuclear pores, and ..
  39. Barbieri E, Trizzino M, Welsh S, Owens T, Calabretta B, Carroll M, et al. Targeted Enhancer Activation by a Subunit of the Integrator Complex. Mol Cell. 2018;71:103-116.e7 pubmed publisher
    ..as an independent sub-module and targets enhancers through Early Growth Response (EGR1/2) TFs and their co-factor NAB2. INTS13 binds poised monocytic enhancers eliciting chromatin looping and activation...
  40. Haller F, Bieg M, Moskalev E, Barthelmeß S, Geddert H, Boltze C, et al. Recurrent mutations within the amino-terminal region of β-catenin are probable key molecular driver events in sinonasal hemangiopericytoma. Am J Pathol. 2015;185:563-71 pubmed publisher
    ..to solitary fibrous tumors of soft tissue and sinonasal tract origin, SN-HPCs were recently shown to lack recurrent NAB2-STAT6 fusion variants...
  41. Demicco E, Wagner M, Maki R, Gupta V, Iofin I, Lazar A, et al. Risk assessment in solitary fibrous tumors: validation and refinement of a risk stratification model. Mod Pathol. 2017;30:1433-1442 pubmed publisher
    Solitary fibrous tumors are an uncommon sarcoma type characterized by NAB2-STAT6 gene fusion...
  42. Zander G, Hackmann A, Bender L, Becker D, Lingner T, Salinas G, et al. mRNA quality control is bypassed for immediate export of stress-responsive transcripts. Nature. 2016;540:593-596 pubmed publisher
    ..In Saccharomyces cerevisiae, the shuttling RNA adaptor proteins Npl3, Gbp2, Hrb1 and Nab2 are loaded co-transcriptionally onto growing pre-mRNAs...
  43. Zhao X, Zeng M, Yang Q, Jing C, Zhang Y. Scrotum solitary fibrous tumor: A case report and review of literature. Medicine (Baltimore). 2017;96:e8854 pubmed publisher
    ..The expression of the new fusion gene, NAB2-STAT6, as an alternative tool specifically confirmed the diagnosis of SFT...
  44. Flores Justa A, Lopez Garcia E, Garcia Allut A, Reyes Santías R. Solitary fibrous tumour/haemangiopericytoma of the spinal cord. Neurocirugia (Astur). 2018;29:309-313 pubmed publisher
    ..tumours/haemangiopericytomas (SFT/HPC) are fibroblastic mesenchymal neoplasms that harbour a genetic fusion of NAB2/STAT6. There are few reported cases in the central nervous system (CNS), of which spinal tumours are minority...
  45. Dagrada G, Spagnuolo R, Mauro V, Tamborini E, Cesana L, Gronchi A, et al. Solitary fibrous tumors: loss of chimeric protein expression and genomic instability mark dedifferentiation. Mod Pathol. 2015;28:1074-83 pubmed publisher
    ..behavior, are rare mesenchymal neoplasias that are currently divided into three main variants that have the NAB2-STAT6 gene fusion as their unifying molecular lesion: usual, malignant and dedifferentiated solitary fibrous tumors...
  46. Trabelsi S, Mama N, Chourabi M, Mastouri M, Ladib M, Popov S, et al. Meningeal Hemangiopericytomas and Meningomas: a Comparative Immunohistochemical and Genetic Study. Asian Pac J Cancer Prev. 2015;16:6871-6 pubmed
    ..Presence of the NAB2-STAT6 fusion gene was inferred by immunohistochemical staining for STAT6...
  47. Galateau Salle F, Churg A, Roggli V, Travis W. The 2015 World Health Organization Classification of Tumors of the Pleura: Advances since the 2004 Classification. J Thorac Oncol. 2016;11:142-54 pubmed publisher
    ..Another useful discovery was that the NAB2-STAT6 fusion is characteristic of solitary fibrous tumors...
  48. Stroebele E, Erives A. Integration of Orthogonal Signaling by the Notch and Dpp Pathways in Drosophila. Genetics. 2016;203:219-40 pubmed publisher
    ..in the genome is located in the BMP-inducible nab locus, a homolog of the vertebrate transcriptional cofactors NAB1/NAB2 We report three major findings...
  49. Soucek S, Zeng Y, Bellur D, Bergkessel M, Morris K, Deng Q, et al. The Evolutionarily-conserved Polyadenosine RNA Binding Protein, Nab2, Cooperates with Splicing Machinery to Regulate the Fate of pre-mRNA. Mol Cell Biol. 2016;36:2697-2714 pubmed publisher
    ..control mRNA processing, we investigated a role for the evolutionarily conserved polyadenosine RNA binding protein, Nab2, in mRNA maturation within the nucleus...
  50. Aibara S, Gordon J, Riesterer A, McLaughlin S, Stewart M. Structural basis for the dimerization of Nab2 generated by RNA binding provides insight into its contribution to both poly(A) tail length determination and transcript compaction in Saccharomyces cerevisiae. Nucleic Acids Res. 2017;45:1529-1538 pubmed publisher
    ..b>Nab2 functions in this process to control both mRNP compaction that facilitates movement through nuclear pore complexes ..
  51. Drampalos E, Mohammad H, Kosmidis C, Balal M, Wong J, Pillai A. Single stage treatment of diabetic calcaneal osteomyelitis with an absorbable gentamicin-loaded calcium sulphate/hydroxyapatite biocomposite: The Silo technique. Foot (Edinb). 2018;34:40-44 pubmed publisher
    ..All had comorbidities (Cierny-Mader (C-M) Class B hosts). The mean age was 68 years (range 50-85)...
  52. Magro G, Angelico G, Leone G, Palazzo J. Solitary fibrous tumor of the breast: report of a case with emphasis on diagnostic role of STAT6 immunostaining. Pathol Res Pract. 2016;212:463-7 pubmed publisher
    ..As STAT6 nuclear immunoexpression is the result of the inv12(q13q13)-derived NAB2-STAT6 fusion, which characterizes SFT, we analyzed immunohistochemically our case with a commercially available ..
  53. Ferreira N, Marais L, Serfontein C. Two stage reconstruction of septic non-union of the humerus with the use of circular external fixation. Injury. 2016;47:1713-8 pubmed publisher
    ..We report on the outcome of eight patients with Cierny and Mader stage IV chronic osteomyelitis of the humerus who underwent debridement followed by bone graft and circular ..
  54. Hastings K, Elizalde D, Muppana L, LeVine S, Kamel C, Ingram W, et al. Nab2 maintains thymus cellularity with aging and stress. Mol Immunol. 2017;85:185-195 pubmed publisher
    ..The transcription factors, Egr1, Egr2 and Egr3, play roles in the thymus and in peripheral T-cell activation. Nab2, which binds Egrs 1, 2, and 3 as a co-regulator of transcription, also regulates peripheral T-cell activation...
  55. Zwart S, Gibson C, Gregory J, Mader T, Stover P, Zeisel S, et al. Astronaut ophthalmic syndrome. FASEB J. 2017;31:3746-3756 pubmed publisher
    ..Zwart, S. R., Gibson, C. R., Gregory, J. F., Mader, T. H., Stover, P. J., Zeisel, S. H., Smith, S. M. Astronaut ophthalmic syndrome.
  56. Guseva N, Tanas M, Stence A, Sompallae R, Schade J, Bossler A, et al. The NAB2-STAT6 gene fusion in solitary fibrous tumor can be reliably detected by anchored multiplexed PCR for targeted next-generation sequencing. Cancer Genet. 2016;209:303-12 pubmed publisher
    ..The behavior of SFT is difficult to predict based on morphology. Recently, an intrachromosomal gene fusion between NAB2 and STAT6 was identified as the defining driving genetic event of SFT and different fusion types correlated with ..
  57. Choi J, Park S, Khang S, Suh Y, Kim S, Lee Y, et al. Hemangiopericytomas in the Central Nervous System: A Multicenter Study of Korean Cases with Validation of the Usage of STAT6 Immunohistochemistry for Diagnosis of Disease. Ann Surg Oncol. 2016;23:954-961 pubmed
    ..Recurrence remains a critical clinical issue of the disease. Identification of NAB2-STAT6 fusion transcript with surrogate IHC marker is a valuable diagnostic tool in the differential diagnosis of ..
  58. Berghoff A, Kresl P, Bienkowski M, Koelsche C, Rajky U, Hainfellner J, et al. Validation of nuclear STAT6 immunostaining as a diagnostic marker of meningeal solitary fibrous tumor (SFT)/hemangiopericytoma. Clin Neuropathol. 2017;36 (2017):56-59 pubmed publisher
    b>NAB2-STAT6 gene fusion is a molecular characteristic of solitary fibrous tumors (SFT) and hemangiopericytoma, underscoring their definition as one diagnostic entity...
  59. Kim J, Choi Y, Kim Y, Park H. Comparison and evaluation of risk factors for meningeal, pleural, and extrapleural solitary fibrous tumors: A clinicopathological study of 92 cases confirmed by STAT6 immunohistochemical staining. Pathol Res Pract. 2017;213:619-625 pubmed publisher
    ..SFTs are translocation-associated neoplasms that can be consistently diagnosed through the evaluation of NAB2/STAT6 gene fusion...
  60. Kao Y, Lin P, Yen S, Huang S, Tsai J, Li C, et al. Clinicopathological and genetic heterogeneity of the head and neck solitary fibrous tumours: a comparative histological, immunohistochemical and molecular study of 36 cases. Histopathology. 2016;68:492-501 pubmed publisher
    Solitary fibrous tumour (SFT) harbours recurrent inv12(q13q13)-derived NAB2-STAT6 fusions, resulting in STAT6 nuclear expression...
  61. Guner G, Bishop J, Bezerra S, Taheri D, Zahavi D, Mendoza Rodriguez M, et al. The utility of STAT6 and ALDH1 expression in the differential diagnosis of solitary fibrous tumor versus prostate-specific stromal neoplasms. Hum Pathol. 2016;54:184-8 pubmed publisher
    ..Prostatic stromal tumors of unknown malignant potential (STUMP) and SFT have overlapping features. NAB2-STAT6 gene fusions that were recently identified in various SFTs lead to nuclear translocalization of STAT6...
  62. Savary C, Rousselet M, Michalak S, Fournier H, Taris M, Loussouarn D, et al. [Solitary fibrous tumors and hemangiopericytomas of the meninges: Immunophenotype and histoprognosis in a series of 17 cases]. Ann Pathol. 2016;36:258-67 pubmed publisher
    ..e. the NAB2-STAT6 gene fusion...
  63. Karthikkeyan G, Nareshkumar R, Aberami S, Sulochana K, Vedantham S, Coral K. Hyperglycemia induced early growth response-1 regulates vascular dysfunction in human retinal endothelial cells. Microvasc Res. 2018;117:37-43 pubmed publisher
  64. Reuter L, Meinel D, Sträßer K. The poly(A)-binding protein Nab2 functions in RNA polymerase III transcription. Genes Dev. 2015;29:1565-75 pubmed publisher
    ..Here, we discovered by a genome-wide approach that Nab2, a poly(A)-binding protein important for correct poly(A) tail length and nuclear mRNA export, is present at all ..
  65. Svaren J, Apel E, Simburger K, Jenkins N, Gilbert D, Copeland N, et al. The Nab2 and Stat6 genes share a common transcription termination region. Genomics. 1997;41:33-9 pubmed
    ..Sequencing of the Nab2 genomic locus revealed that it is situated very close to the Stat6 gene...
  66. Barthelmeß S, Geddert H, Boltze C, Moskalev E, Bieg M, Sirbu H, et al. Solitary fibrous tumors/hemangiopericytomas with different variants of the NAB2-STAT6 gene fusion are characterized by specific histomorphology and distinct clinicopathological features. Am J Pathol. 2014;184:1209-1218 pubmed publisher
    Recurrent somatic fusions of the two genes, NGFI-A-binding protein 2 (NAB2) and STAT6, located at chromosomal region 12q13, have been recently identified to be presumable tumor-initiating events in solitary fibrous tumors (SFT)...
  67. Nishio J, Iwasaki H, Aoki M, Nabeshima K, Naito M. FDG PET/CT and MR imaging of CD34-negative soft-tissue solitary fibrous tumor with NAB2-STAT6 fusion gene. Anticancer Res. 2015;35:967-71 pubmed
    ..To the best of our knowledge, this is the first report showing the FDG PET/CT findings of soft-tissue SFT. ..
  68. Drabovich A, Pavlou M, Schiza C, Diamandis E. Dynamics of Protein Expression Reveals Primary Targets and Secondary Messengers of Estrogen Receptor Alpha Signaling in MCF-7 Breast Cancer Cells. Mol Cell Proteomics. 2016;15:2093-107 pubmed publisher
    ..of protein expression in a rarely studied network of transcription factors with a negative feedback loop (ER?-EGR3-NAB2)...
  69. Murakami K, Nakamura Y, Felizola S, Morimoto R, Satoh F, Takanami K, et al. Pancreatic solitary fibrous tumor causing ectopic adrenocorticotropic hormone syndrome. Mol Cell Endocrinol. 2016;436:268-73 pubmed publisher
    ..The diagnosis of the solitary fibrous tumor was confirmed by the identification of the NAB2-STAT6 fusion gene and positive immuno-histochemical staining for STAT6 and CD34...
  70. Granada M, Wilk J, Tuzova M, Strachan D, Weidinger S, Albrecht E, et al. A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. J Allergy Clin Immunol. 2012;129:840-845.e21 pubmed publisher
    ..It also confirmed the association of the known susceptibility loci FCER1A, STAT6, and IL13 for the dysregulation of total IgE. ..
  71. Yamada Y, Kohashi K, Bekki H, Ishii T, Iura K, Maekawa A, et al. Malignant solitary fibrous tumor with high-grade nuclear atypia: an alternate entity for the undetermined tumor group. Pathol Res Pract. 2015;211:117-24 pubmed publisher
    Recently, a novel fusion transcript, NAB2-STAT6, and its variants have also been reported to be specific diagnostic markers for solitary fibrous tumors (SFTs)...
  72. Tai H, Chuang I, Chen T, Li C, Huang S, Kao Y, et al. NAB2-STAT6 fusion types account for clinicopathological variations in solitary fibrous tumors. Mod Pathol. 2015;28:1324-35 pubmed publisher
    Solitary fibrous tumor (SFT) is characterized by the inv12(q13q13)-derived NAB2-STAT6 fusion, which exhibits variable breakpoints and drives STAT6 nuclear expression...
  73. Huang S, Li C, Kao Y, Chuang I, Tai H, Tsai J, et al. The clinicopathological significance of NAB2-STAT6 gene fusions in 52 cases of intrathoracic solitary fibrous tumors. Cancer Med. 2016;5:159-68 pubmed publisher
    b>NAB2-STAT6 gene fusion drives STAT6 nuclear expression and is the pathognomonic hallmark of solitary fibrous tumors (SFTs)...
  74. Diamandis P, Ferrer Luna R, Huang R, Folkerth R, Ligon A, Wen P, et al. Case Report: Next generation sequencing identifies a NAB2-STAT6 fusion in Glioblastoma. Diagn Pathol. 2016;11:13 pubmed publisher
    ..R132H), TP53 (p.Y126_splice), ATRX (p.R1302fs*), HNF1A (p.R263H) and NF1 (p.H2592del) variants and a NAB2-STAT6 gene fusion event involving NAB2 exon 3 and STAT6 exon 18...
  75. Nakada S, Minato H, Nojima T. Clinicopathological differences between variants of the NAB2-STAT6 fusion gene in solitary fibrous tumors of the meninges and extra-central nervous system. Brain Tumor Pathol. 2016;33:169-74 pubmed publisher
    Investigations on the NAB2-STAT6 fusion gene in solitary fibrous tumors (SFTs) and hemangiopericytomas (HPCs) have increased since its discovery in 2013...
  76. Rekhi B, Shetty O, Tripathi P, Bapat P, Ramadwar M, Bajpai J, et al. Molecular characterization of a series of solitary fibrous tumors, including immunohistochemical expression of STAT6 and NATB2-STAT6 fusion transcripts, using Reverse Transcriptase(RT)-Polymerase chain reaction(PCR) technique: An Indian experience. Pathol Res Pract. 2017;213:1404-1411 pubmed publisher
    ..Recent studies have unraveled STAT6 as a useful diagnostic immunohistochemical (IHC) marker for a SFT and NAB2-STAT6 as its specific gene fusion transcript...
  77. Tardio J, Machado I, Alemany I, López Soto M, Nieto M, Llombart Bosch A. Solitary Fibrous Tumor of the Vulva: Report of 2 Cases, Including a De Novo Dedifferentiated Solitary Fibrous Tumor Diagnosed After Molecular Demonstration of NAB2-STAT6 Gene Fusion. Int J Gynecol Pathol. 2018;37:547-553 pubmed publisher
    ..STAT6 staining, which could only be correctly diagnosed after molecular analysis with demonstration of a NAB2-STAT6 gene fusion...
  78. Kumbrink J, Gerlinger M, Johnson J. Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop. J Biol Chem. 2005;280:42785-93 pubmed
    ..Egr-1 activity is modulated in part through the binding of corepressors Nab1 and Nab2. Nab2 appears crucial for controlling Egr-1-mediated transactivation because it is a delayed early response gene, ..
  79. Kumbrink J, Kirsch K. Regulation of p130(Cas)/BCAR1 expression in tamoxifen-sensitive and tamoxifen-resistant breast cancer cells by EGR1 and NAB2. Neoplasia. 2012;14:108-20 pubmed
    ..factor EGR1 were identified in the 5' region of BCAR1, the p130(Cas)/BCAR1 regulation by EGR1 and its coregulator NAB2 was investigated...
  80. Mohajeri A, Tayebwa J, Collin A, Nilsson J, Magnusson L, Von Steyern F, et al. Comprehensive genetic analysis identifies a pathognomonic NAB2/STAT6 fusion gene, nonrandom secondary genomic imbalances, and a characteristic gene expression profile in solitary fibrous tumor. Genes Chromosomes Cancer. 2013;52:873-86 pubmed publisher
    ..banding and fluorescence in situ hybridization (FISH) showed recurrent breakpoints in 12q13, clustering near the NAB2 and STAT6 genes, and single nucleotide polymorphism array analysis disclosed frequent deletions affecting STAT6...
  81. Koelsche C, Schweizer L, Renner M, Warth A, Jones D, Sahm F, et al. Nuclear relocation of STAT6 reliably predicts NAB2-STAT6 fusion for the diagnosis of solitary fibrous tumour. Histopathology. 2014;65:613-22 pubmed publisher
    Nuclear relocation of STAT6 has been shown in tumours with NAB2-STAT6 fusion, and has been proposed as an ancillary marker for the diagnosis of solitary fibrous tumours (SFTs)...
  82. Akaike K, Kurisaki Arakawa A, Hara K, Suehara Y, Takagi T, Mitani K, et al. Distinct clinicopathological features of NAB2-STAT6 fusion gene variants in solitary fibrous tumor with emphasis on the acquisition of highly malignant potential. Hum Pathol. 2015;46:347-56 pubmed publisher
    The impact of NGFI-A binding protein 2 (NAB2)-signal transducer and activator of transcription 6 (STAT6) fusion on the biological behavior and the mechanism of acquisition of malignant phenotype in solitary fibrous tumor (SFT) is not well ..
  83. Fritchie K, Jin L, Rubin B, Burger P, Jenkins S, Barthelmeß S, et al. NAB2-STAT6 Gene Fusion in Meningeal Hemangiopericytoma and Solitary Fibrous Tumor. J Neuropathol Exp Neurol. 2016;75:263-71 pubmed publisher
    ..They harbor NAB2-STAT6 fusions similar to their soft tissue counterparts, supporting the view that they are part of a tumor ..
  84. Yuzawa S, Nishihara H, Wang L, Tsuda M, Kimura T, Tanino M, et al. Analysis of NAB2-STAT6 Gene Fusion in 17 Cases of Meningeal Solitary Fibrous Tumor/Hemangiopericytoma: Review of the Literature. Am J Surg Pathol. 2016;40:1031-40 pubmed publisher
    ..thoracic cavity and soft tissue has been histologically considered a single biological entity termed SFT; in fact, NAB2-STAT6 gene fusion was recently identified in both diseases...
  85. Bahrami A, Lee S, Schaefer I, Boland J, Patton K, Pounds S, et al. TERT promoter mutations and prognosis in solitary fibrous tumor. Mod Pathol. 2016;29:1511-1522 pubmed publisher
    ..Solitary fibrous tumor is a mesenchymal neoplasm exhibiting a broad spectrum of biological behavior and harboring the NAB2-STAT6 fusion...
  86. Fusco N, Guerini Rocco E, Augello C, Terrasi A, Ercoli G, Fumagalli C, et al. Recurrent NAB2-STAT6 gene fusions and oestrogen receptor-? expression in pulmonary adenofibromas. Histopathology. 2017;70:906-917 pubmed publisher
    ..as well as electron microscopy and capillary sequencing on microdissected samples to evaluate the presence of NAB2-STAT6 fusion genes and MED12 exon 2 mutations in their discrete components...
  87. Friedlander P, Wassmann K, Christenfeld A, Fisher D, Kyi C, Kirkwood J, et al. Whole-blood RNA transcript-based models can predict clinical response in two large independent clinical studies of patients with advanced melanoma treated with the checkpoint inhibitor, tremelimumab. J Immunother Cancer. 2017;5:67 pubmed publisher
    ..pre-treatment classifier model (containing ADAM17, CDK2, CDKN2A, DPP4, ERBB2, HLA-DRA, ICOS, ITGA4, LARGE, MYC, NAB2, NRAS, RHOC, TGFB1, and TIMP1) achieved an area under the curve (AUC) of 0.86 (95% confidence interval 0.81 to 0...
  88. Mandell J, Khurana B, Smith J, Czuczman G, Ghazikhanian V, Smith S. Osteomyelitis of the lower extremity: pathophysiology, imaging, and classification, with an emphasis on diabetic foot infection. Emerg Radiol. 2018;25:175-188 pubmed publisher
    ..The two most common classification schemes are those of Lew and Waldvogel, and Cierny and Mader. Brodie's abscess is seen in subacute osteomyelitis, while sequestrum, involucrum, and cloaca are inter-related ..
  89. Dudareva M, Ferguson J, Riley N, Stubbs D, Atkins B, McNally M. Osteomyelitis of the Pelvic Bones: A Multidisciplinary Approach to Treatment. J Bone Jt Infect. 2017;2:184-193 pubmed publisher
    ..2 years, range 16.8-80.6) underwent surgery. According to the Cierny-Mader classification of osteomyelitis there were 19 type II, 35 type III and 7 type IV cases...
  90. Nilsson H, Montano G, Ullmark T, Lennartsson A, Drott K, Järvstråt L, et al. The transcriptional coregulator NAB2 is a target gene for the Wilms' tumor gene 1 protein (WT1) in leukemic cells. Oncotarget. 2017;8:87136-87150 pubmed publisher
    ..Here, we identify the transcriptional coregulator NAB2 as a target gene of WT1...
  91. Qu Z, Wolfraim L, Svaren J, Ehrengruber M, Davidson N, Milbrandt J. The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells. J Cell Biol. 1998;142:1075-82 pubmed
    ..are the rapid activation of the zinc finger transcription factor Egr1/NGFI-A, and a slightly delayed induction of NAB2, a corepressor that inhibits Egr1 transcriptional activity...
  92. Abdulkadir S, Qu Z, Garabedian E, Song S, Peters T, Svaren J, et al. Impaired prostate tumorigenesis in Egr1-deficient mice. Nat Med. 2001;7:101-7 pubmed
    ..These results indicate a unique role for Egr1 in regulating the transition from localized, carcinoma in situ to invasive carcinoma. ..