Gene Symbol: MYRF
Description: myelin regulatory factor
Alias: C11orf9, MRF, Ndt80, pqn-47, myelin regulatory factor, myelin gene regulatory factor
Montano S, Coté M, Fingerman I, Pierce M, Vershon A, Georgiadis M. Crystal structure of the DNA-binding domain from Ndt80, a transcriptional activator required for meiosis in yeast. Proc Natl Acad Sci U S A. 2002;99:14041-6 pubmed
..results suggest that Ndt80 is the defining member of a previously uncharacterized family of transcription factors, including the human protein (C11orf9), which has been shown to be highly expressed in invasive or metastatic tumor cells.
Emery B, Agalliu D, Cahoy J, Watkins T, Dugas J, Mulinyawe S, et al
. Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination. Cell. 2009;138:172-85 pubmed publisher
..Here we identify gene model 98, which we have named myelin gene regulatory factor (MRF), as a transcriptional regulator required for CNS myelination...
Koenning M, Jackson S, Hay C, Faux C, Kilpatrick T, Willingham M, et al
. Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS. J Neurosci. 2012;32:12528-42 pubmed publisher
..whether continued oligodendrocyte expression of the recently identified transcription factor myelin gene regulatory factor (MRF) is required to maintain the integrity of myelin in the adult CNS...
Stohr H, Marquardt A, White K, Weber B. cDNA cloning and genomic structure of a novel gene (C11orf9) localized to chromosome 11q12-->q13.1 which encodes a highly conserved, potential membrane-associated protein. Cytogenet Cell Genet. 2000;88:211-6 pubmed
We have cloned and characterized a novel gene (C11orf9) mapping to chromosome 11q12-->q13.1...
Cooper P, Nowak N, Higgins M, Church D, Shows T. Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes. Genomics. 1998;49:419-29 pubmed
..These experiments identify candidate genes for disorders that map to this region and indicate that this is a gene-rich region of the human genome. ..
Li Z, Park Y, Marcotte E. A Bacteriophage tailspike domain promotes self-cleavage of a human membrane-bound transcription factor, the myelin regulatory factor MYRF. PLoS Biol. 2013;11:e1001624 pubmed publisher
..CNS myelination occurs as oligodendrocytes terminally differentiate, a process regulated in part by the myelin regulatory factor, MYRF...
Kim D, Choi J, Fan C, Shearer R, Sharif M, Busch P, et al
. Homo-trimerization is essential for the transcription factor function of Myrf for oligodendrocyte differentiation. Nucleic Acids Res. 2017;45:5112-5125 pubmed publisher
b>Myrf is a key transcription factor for oligodendrocyte differentiation and central nervous system myelination...
Duncan G, Plemel J, Assinck P, Manesh S, Muir F, Hirata R, et al
. Myelin regulatory factor drives remyelination in multiple sclerosis. Acta Neuropathol. 2017;134:403-422 pubmed publisher
..In particular, the oligodendrocyte transcription factor myelin regulatory factor (MYRF) is essential for myelination during development, but its role during remyelination and expression ..
Bujalka H, Koenning M, Jackson S, Perreau V, Pope B, Hay C, et al
. MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes. PLoS Biol. 2013;11:e1001625 pubmed publisher
..We previously identified a putative transcription factor, Myelin Regulatory Factor (Myrf), as being vital for CNS myelination...