myoglobin

Summary

Gene Symbol: myoglobin
Description: myoglobin
Alias: PVALB, myoglobgin, myoglobin
Species: human
Products:     myoglobin

Top Publications

  1. Flonta S, Arena S, Pisacane A, Michieli P, Bardelli A. Expression and functional regulation of myoglobin in epithelial cancers. Am J Pathol. 2009;175:201-6 pubmed publisher
    b>Myoglobin is a multifunctional heme protein that is thought to be expressed exclusively in myocytes. Its importance in both oxygen transport and free radical scavenging has been extensively characterized...
  2. Zhao S, Ting J, Atallah H, Qiu L, Tan J, Gloss B, et al. Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. Nat Methods. 2011;8:745-52 pubmed
    ..characterization of the newly established VGAT-ChR2(H134R)-EYFP, ChAT-ChR2(H134R)-EYFP, Tph2-ChR2(H134R)-EYFP and Pvalb(H134R)-ChR2-EYFP BAC transgenic mouse lines and demonstrate the utility of these lines for precisely controlling ..
  3. Shukla R, Prévôt T, French L, Isserlin R, Rocco B, Banasr M, et al. The Relative Contributions of Cell-Dependent Cortical Microcircuit Aging to Cognition and Anxiety. Biol Psychiatry. 2019;85:257-267 pubmed publisher
    ..acidergic neurons expressing vasoactive intestinal peptide (Vip), somatostatin (Sst), and parvalbumin (Pvalb)...
  4. Mateo Montero R, Pedrera Mazarro A, Martín Palomeque G, Del Mar Moreno Galera M, Valera Dávila C, Gómez Ansede A, et al. Clinical and genetical study of a familial form of REM sleep behavior disorder. Clin Neurol Neurosurg. 2018;175:130-133 pubmed publisher
    ..exome variants shared by two affected cases the pool of variants could be reduced to thirteen; one of them is in PVALB, a calcium-binding albumin protein present in gabaergic interneurons in the nervous system that inhibit the ..
  5. Kaiser T, Ting J, Monteiro P, Feng G. Transgenic labeling of parvalbumin-expressing neurons with tdTomato. Neuroscience. 2016;321:236-245 pubmed publisher
    Parvalbumin (PVALB)-expressing fast-spiking interneurons subserve important roles in many brain regions by modulating circuit function and dysfunction of these neurons is strongly implicated in neuropsychiatric disorders including ..
  6. Hsu C, Lai W, Lin Y, Tain Y. Postnatal high-fat diet sex-specifically exacerbates prenatal dexamethasone-induced hypertension: Mass spectrometry-based quantitative proteomic approach. J Nutr Biochem. 2018;57:268-275 pubmed publisher
    ..In males, DEX?+?HF increased renal parvalbumin (PVALB) and carbonic anhydrase III (CA III) protein levels...
  7. Dipoppa M, Ranson A, Krumin M, Pachitariu M, Carandini M, Harris K. Vision and Locomotion Shape the Interactions between Neuron Types in Mouse Visual Cortex. Neuron. 2018;98:602-615.e8 pubmed publisher
    ..interaction of multiple neuronal types, including pyramidal (Pyr) cells and interneurons expressing Sst, Vip, or Pvalb. To study the circuit underlying such interactions, we imaged these four types of cells in mouse primary visual ..
  8. Weller P, Jeffreys A, Wilson V, Blanchetot A. Organization of the human myoglobin gene. EMBO J. 1984;3:439-46 pubmed
    Cross-hybridization of the grey seal myoglobin gene to human DNA detected a single human myoglobin gene plus an extensive family of sequences apparently related to the central exon of this gene. The functional human gene is 10...
  9. Mendes T, Nozima B, Budu A, de Souza R, Braga Catroxo M, Delcelo R, et al. PVALB diminishes [Ca2+] and alters mitochondrial features in follicular thyroid carcinoma cells through AKT/GSK3β pathway. Endocr Relat Cancer. 2016;23:769-82 pubmed publisher
    We have identified previously a panel of markers (C1orf24, ITM1 and PVALB) that can help to discriminate benign from malignant thyroid lesions...

More Information

Publications98

  1. Romero Herrera A, Lehmann H. The myoglobin of primates. I. Hylobates agilis (gibbon). Biochim Biophys Acta. 1971;251:482-8 pubmed
    The myoglobin of a gibbon has been compared with that of man. There was only one difference, residue 23 (B4) which is Gly in man was found to be Ser in the gibbon...
  2. Brown J, Ramikie T, Schmidt M, Báldi R, Garbett K, Everheart M, et al. Inhibition of parvalbumin-expressing interneurons results in complex behavioral changes. Mol Psychiatry. 2015;20:1499-507 pubmed publisher
    ..GAD67 downregulation occurs in multiple interneuronal sub-populations, including the parvalbumin-positive (PVALB+) cells...
  3. Huo C, Liu X, Zhao J, Zhao T, Huang H, Ye H. Abnormalities in behaviour, histology and prefrontal cortical gene expression profiles relevant to schizophrenia in embryonic day 17 MAM-Exposed C57BL/6 mice. Neuropharmacology. 2018;140:287-301 pubmed publisher
    ..Moreover, expression of Pvalb, Arc and genes in their association networks were downregulated in the PFC of female MAM-exposed mice...
  4. Boldog E, Bakken T, Hodge R, Novotny M, Aevermann B, Baka J, et al. Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type. Nat Neurosci. 2018;21:1185-1195 pubmed publisher
    ..an immunohistochemical profile (GAD1+CCK+, CNR1-SST-CALB2-PVALB-) matching a single transcriptomically defined cell type whose specific molecular marker signature is ..
  5. Nakajima K, Masubuchi Y, Ito Y, Inohana M, Takino M, Saegusa Y, et al. Developmental exposure of citreoviridin transiently affects hippocampal neurogenesis targeting multiple regulatory functions in mice. Food Chem Toxicol. 2018;120:590-602 pubmed publisher
    ..changes of an outside regulatory system suggested suppressed function of GABAergic interneurons, especially of PVALB+ interneurons for compensation on neural stem cell reduction...
  6. Fan Y, Xiao S. Progression Rate Associated Peripheral Blood Biomarkers of Parkinson's Disease. J Mol Neurosci. 2018;65:312-318 pubmed publisher
    ..Among these DEGs, ZFAND4, SRMS, UBL4B, PVALB, DIRAS1, PDP2, LRCH1, and MYL4 were potential progression rate associated biomarkers of PD...
  7. Kikuchihara Y, Abe H, Tanaka T, Kato M, Wang L, Ikarashi Y, et al. Relationship between brain accumulation of manganese and aberration of hippocampal adult neurogenesis after oral exposure to manganese chloride in mice. Toxicology. 2015;331:24-34 pubmed publisher
    ..Reduction of parvalbumin (Pvalb)(+) γ-aminobutyric acid (GABA)-ergic interneurons in the hilus of the dentate gyrus along with promoter region ..
  8. Wang Y, Rajanbabu V, Chen J. Transcriptome analysis of medaka following epinecidin-1 and TH1-5 treatment of NNV infection. Fish Shellfish Immunol. 2015;42:121-31 pubmed publisher
    ..Medaka infected with NNV exhibited up-regulation of PVALB, CEBPA, IFIM, IFN, IL-6ST, NF-kB2, SOC3, SP1, and TGFB1, and such increases were prevented by pre-treatment with ..
  9. Boron I, Capece L, Pennacchietti F, Wetzler D, Bruno S, Abbruzzetti S, et al. Engineered chimeras reveal the structural basis of hexacoordination in globins: a case study of neuroglobin and myoglobin. Biochim Biophys Acta. 2015;1850:169-77 pubmed publisher
    b>Myoglobin (Mb) and neuroglobin (Ngb) are representative members of pentacoordinated and bis-histidyl, hexacoordinated globins. In spite of their low sequence identity, they show surprisingly similar three-dimensional folds...
  10. Muñoz Manchado A, Bengtsson Gonzales C, Zeisel A, Munguba H, Bekkouche B, Skene N, et al. Diversity of Interneurons in the Dorsal Striatum Revealed by Single-Cell RNA Sequencing and PatchSeq. Cell Rep. 2018;24:2179-2190.e7 pubmed publisher
    ..Surprisingly, the Pvalb-expressing cells do not constitute a discrete cluster but rather are part of a larger group of cells expressing ..
  11. Rossier J, Bernard A, Cabungcal J, Perrenoud Q, Savoye A, Gallopin T, et al. Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin. Mol Psychiatry. 2015;20:154-61 pubmed publisher
    ..Among these five clusters, two fast-spiking interneuron clusters expressing the calcium-binding protein Pvalb were identified, one co-expressing Pvalb with Sst (PV-Sst) and another co-expressing Pvalb with three ..
  12. Chu W, Liu L, Chen L, Yang P, Li Y, Wang Y, et al. Rapid Muscle Relaxation in Siniperca chuatsi is Coordinated by Parvalbumin (PVALB) and MiR-181a. Curr Mol Med. 2015;15:772-9 pubmed
    ..In the study, four PVALB isoforms, named as PVALB1, 2, 3, and 4, were identified in the mandarin fish (Siniperca chuatsi) fast muscle and ..
  13. Filice F, Vörckel K, Sungur A, Wöhr M, Schwaller B. Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism. Mol Brain. 2016;9:10 pubmed publisher
    ..Similar findings were obtained in heterozygous (PV+/-) mice for the Pvalb gene, which display a robust ASD-like phenotype...
  14. Liu M, Fitzgibbon M, Wang Y, Reilly J, Qian X, O BRIEN T, et al. Ulk4 regulates GABAergic signaling and anxiety-related behavior. Transl Psychiatry. 2018;8:43 pubmed publisher
    ..Transcriptome analyses revealed a marked reduction of GABAergic neuronal subtypes, including Pvalb, Sst, Cck, Npy, and Nos3, as well as significant upregulation of GABA receptors, including Gabra1, Gabra3, Gabra4, ..
  15. Kawashima M, Watanabe Y, Nakajima K, Murayama H, Nagahara R, Jin M, et al. Late effect of developmental exposure to glycidol on hippocampal neurogenesis in mice: Loss of parvalbumin-expressing interneurons. Exp Toxicol Pathol. 2017;69:517-526 pubmed publisher
    ..The offspring of the dams that had received 1600ppm glycidol had fewer parvalbumin (PVALB)+ ?-aminobutyric acid (GABA)-ergic interneurons and neuron-specific nuclear protein+ ..
  16. Nassar M, Simonnet J, Lofredi R, Cohen I, Savary E, Yanagawa Y, et al. Diversity and overlap of parvalbumin and somatostatin expressing interneurons in mouse presubiculum. Front Neural Circuits. 2015;9:20 pubmed publisher
    ..Little is known about GABAergic interneurons of this region. Here, we used three transgenic mouse lines, Pvalb-Cre, Sst-Cre, and X98, to examine distinct interneurons labeled with tdTomato or green fluorescent protein...
  17. O Toole S, Ferrer M, Mekonnen J, Zhang H, Shima Y, Ladle D, et al. Dicer maintains the identity and function of proprioceptive sensory neurons. J Neurophysiol. 2017;117:1057-1069 pubmed publisher
    ..By conditionally ablating Dicer in mice, using parvalbumin (Pvalb)-driven Cre recombinase, we impaired posttranscriptional regulation in the proprioceptive sensory neuron ..
  18. Zhang W, Jia Y, Wang F, Du Q, Chang Z. Identification of differentially-expressed genes in early developmental ovary of Yellow River carp (Cyprinus carpio var) using Suppression Subtractive Hybridization. Theriogenology. 2017;97:9-16 pubmed publisher
    ..Twenty-two candidate genes were selected and further characterized using qRT-PCR. Pvalb, epd, and MYH were found specifically expressed in PG, while bmp2b, desmin and fp1 were specifically expressed in ..
  19. Xu M, Lin J, Lei C, Liu J, Yuan R, Tan G, et al. High Level of Serum Myoglobin in Human Intracerebral Hemorrhage: Implications for Large Hematoma Volume and Growth. J Stroke Cerebrovasc Dis. 2016;25:1582-1589 pubmed publisher
    b>Myoglobin and cardiac troponin T are often elevated in patients with ischemic stroke...
  20. Watanabe Y, Murakami T, Kawashima M, Hasegawa Baba Y, Mizukami S, Imatanaka N, et al. Maternal Exposure to Valproic Acid Primarily Targets Interneurons Followed by Late Effects on Neurogenesis in the Hippocampal Dentate Gyrus in Rat Offspring. Neurotox Res. 2017;31:46-62 pubmed publisher
    ..dentate gyrus, the number of reelin+ interneurons decreased at ≥667 ppm, and the number of PVALB+ or GAD67+ interneurons decreased at 2000 ppm...
  21. Appelbaum T, Becker D, Santana E, Aguirre G. Molecular studies of phenotype variation in canine RPGR-XLPRA1. Mol Vis. 2016;22:319-31 pubmed
    ..genes (RHO, OPN1LW, OPN1MW, RLBP1, RPGRORF15, RAB8A, RPGRIP1L, CEP290, CC2D2A, DFNB31, RAB11B, CRX, RCVRN, PVALB, CALB1, FGFR1, NTRK2, and NTRK3) involved in neuronal function...
  22. Gaskin P, Toledo Rodriguez M, Alexander S, Fone K. Down-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia. Int J Neuropsychopharmacol. 2016;19: pubmed publisher
    ..neurotransmission, and GABA receptor signaling and in specific schizophrenia-linked genes, including parvalbumin (PVALB) and GAD67, in PCP-SI rats, which resemble changes reported in schizophrenia...
  23. Bassel Duby R, Hernandez M, Yang Q, Rochelle J, Seldin M, Williams R. Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. Mol Cell Biol. 1994;14:4596-605 pubmed
    A sequence motif (CCAC box) within an upstream enhancer region of the human myoglobin gene is essential for transcriptional activity in both cardiac and skeletal muscle...
  24. Phillips E, Hasenstaub A. Asymmetric effects of activating and inactivating cortical interneurons. elife. 2016;5: pubmed publisher
    ..Optogenetically manipulating somatostatin-positive (Sst+) or parvalbumin-positive (Pvalb+) interneurons while recording tone-responses showed that Sst+ inactivation increased response gain, while Pvalb+ ..
  25. Corbett J, Wheeler C, Baker C, Yacoub M, Dunn M. The human myocardial two-dimensional gel protein database: update 1994. Electrophoresis. 1994;15:1459-65 pubmed
    ..Electrophoresis) 1994, 15, 685-607). This database is being used in studies of alterations in protein expression in the diseased and transplanted human heart. ..
  26. Wang Y, Ma C, Sun Y, Li Y, Kang L, Jiang Y. Dynamic transcriptome and DNA methylome analyses on longissimus dorsi to identify genes underlying intramuscular fat content in pigs. BMC Genomics. 2017;18:780 pubmed publisher
    ..genes showing differences in DNA methylation in gene body or intergenic region were detected, such as FASN, PVALB, ID2, SH3PXD2B and EGR1...
  27. Bicker A, Dietrich D, Gleixner E, Kristiansen G, Gorr T, Hankeln T. Extensive transcriptional complexity during hypoxia-regulated expression of the myoglobin gene in cancer. Hum Mol Genet. 2014;23:479-90 pubmed publisher
    Recently, the ectopic expression of myoglobin (MB) was reported in human epithelial cancer cell lines and breast tumor tissues, where MB expression increased with hypoxia...
  28. Shiraki A, Tanaka T, Watanabe Y, Saito F, Akahori Y, Imatanaka N, et al. Immunohistochemistry of aberrant neuronal development induced by 6-propyl-2-thiouracil in rats. Toxicol Lett. 2016;261:59-71 pubmed publisher
    ..subpopulations, there were more RELN+, CALB2+, and SST+ cells and fewer PVALB+ cells in the dentate hilus...
  29. Kristiansen G, Hu J, Wichmann D, Stiehl D, Rose M, Gerhardt J, et al. Endogenous myoglobin in breast cancer is hypoxia-inducible by alternative transcription and functions to impair mitochondrial activity: a role in tumor suppression?. J Biol Chem. 2011;286:43417-28 pubmed publisher
    Recently, immunohistochemical analysis of myoglobin (MB) in human breast cancer specimens has revealed a surprisingly widespread expression of MB in this nonmuscle context...
  30. Arndt H K, Florian G, A S, Andres B, Angela K, Anton M. Associated factors for non-ischemic serum myoglobin release after cardiac surgical procedures. Heart Surg Forum. 2014;17:E163-8 pubmed publisher
    b>Myoglobin has become established as a serum marker of myocardial injury. However, myoglobin levels can increase exponentially without any correlation to postoperative clinical ischemia symptoms...
  31. Boulton F, Huntsman R, Lorkin P, Lehmann H. Abnormal human myoglobin: 53 (D4) glutamic acid--lysine. Nature. 1969;223:832-3 pubmed
  32. Katina N, Ilyina N, Kashparov I, Balobanov V, Vasiliev V, Bychkova V. Apomyoglobin mutants with single point mutations at val10 can form amyloid structures at permissive temperature. Biochemistry (Mosc). 2011;76:555-63 pubmed publisher
  33. Ishikawa H, Takahashi S, Ishimori K, Morishima I. Steric effects of isoleucine 107 on heme reorientation reaction in human myoglobin. Biochem Biophys Res Commun. 2004;324:1095-100 pubmed
    Structural factors to regulate the heme reorientation reaction in myoglobin were examined and we found that the side chain at position 107 (Ile107), which is located between the 2-vinyl and 3-methyl groups of heme, forms a kinetic ..
  34. Moore L, Zamudio S, Zhuang J, Droma T, Shohet R. Analysis of the myoglobin gene in Tibetans living at high altitude. High Alt Med Biol. 2002;3:39-47 pubmed
    b>Myoglobin, a protein with an important role in muscle oxidative metabolism, is increased in high altitude residents. In the closely related hemoglobins, mutations cause or contribute to human disease...
  35. Boechi L, Arrar M, Marti M, Olson J, Roitberg A, Estrin D. Hydrophobic effect drives oxygen uptake in myoglobin via histidine E7. J Biol Chem. 2013;288:6754-62 pubmed publisher
    Since the elucidation of the myoglobin (Mb) structure, a histidine residue on the E helix (His-E7) has been proposed to act as a gate with an open or closed conformation controlling access to the active site...
  36. Rayner B, Wu B, Raftery M, Stocker R, Witting P. Human S-nitroso oxymyoglobin is a store of vasoactive nitric oxide. J Biol Chem. 2005;280:9985-93 pubmed
    Nitric oxide (.NO) regulates vascular function, and myoglobin (Mb) is a heme protein present in skeletal, cardiac, and smooth muscle, where it facilitates O(2) transfer. Human ferric Mb binds ...
  37. Kunishige M, Mitsui T, Akaike M, Kawajiri M, Shono M, Kawai H, et al. Overexpressions of myoglobin and antioxidant enzymes in ragged-red fibers of skeletal muscle from patients with mitochondrial encephalomyopathy. Muscle Nerve. 2003;28:484-92 pubmed
    To determine the relationship between myoglobin (Mb) and the defense system against reactive oxygen species in various myopathies, we performed immunohistochemical analyses of Mb and various antioxidant enzymes, including manganese ..
  38. Hubbard S, Hendrickson W, Lambright D, Boxer S. X-ray crystal structure of a recombinant human myoglobin mutant at 2.8 A resolution. J Mol Biol. 1990;213:215-8 pubmed
    We have grown crystals in trigonal space group P3(2)21 of a mutant human myoglobin, aquomet form, in which lysine at position 45 has been replaced by arginine and cysteine at position 110 has been replaced by alanine...
  39. Liapis H, Boils C, Hennigar R, Silva F. Myoglobin casts in renal biopsies: immunohistochemistry and morphologic spectrum. Hum Pathol. 2016;54:25-30 pubmed publisher
    Five hundred eighty renal biopsies from a pool of 27850 archived cases were identified in which a myoglobin stain was performed because of atypical casts...
  40. Zhong S, Wu B, Han Y, Cao Y, Yang L, Luo S, et al. Identification of Driver Genes and Key Pathways of Pediatric Brain Tumors and Comparison of Molecular Pathogenesis Based on Pathologic Types. World Neurosurg. 2017;107:990-1000 pubmed publisher
    ..hub genes were somatostatin (SST), glutamate decarboxylase 2 (GAD2), and single copy human parvalbumin gene (PVALB)...
  41. Kanatous S, Mammen P, Rosenberg P, Martin C, White M, Dimaio J, et al. Hypoxia reprograms calcium signaling and regulates myoglobin expression. Am J Physiol Cell Physiol. 2009;296:C393-402 pubmed publisher
    b>Myoglobin is an oxygen storage molecule that is selectively expressed in cardiac and slow-twitch skeletal muscles that have a high oxygen demand...
  42. Weekes J, Morrison K, Mullen A, Wait R, Barton P, Dunn M. Hyperubiquitination of proteins in dilated cardiomyopathy. Proteomics. 2003;3:208-16 pubmed
    ..A number of these proteins were identified using affinity purification and matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry. ..
  43. Vuotikka P, Ylitalo K, Vuori J, Vaananen K, Kaukoranta P, Lepojärvi M, et al. Serum myoglobin/carbonic anhydrase III ratio in the diagnosis of perioperative myocardial infarction during coronary bypass surgery. Scand Cardiovasc J. 2003;37:23-9 pubmed
    The purpose of the present study was to evaluate the usefulness of the myoglobin/carboanhydrase III (Myo/CAIII) ratio in the diagnosis of perioperative myocardial infarction during coronary artery bypass surgery...
  44. Endeward V, Gros G, Jürgens K. Significance of myoglobin as an oxygen store and oxygen transporter in the intermittently perfused human heart: a model study. Cardiovasc Res. 2010;87:22-9 pubmed publisher
    ..wall escapes anoxia during the systolic phase of low blood perfusion are investigated, especially the role of myoglobin (Mb), which can (i) store oxygen and (ii) facilitate intracellular oxygen transport...
  45. Bicker A, Brahmer A, Meller S, Kristiansen G, Gorr T, Hankeln T. The Distinct Gene Regulatory Network of Myoglobin in Prostate and Breast Cancer. PLoS ONE. 2015;10:e0142662 pubmed publisher
    b>Myoglobin (MB) is not only strongly expressed in myocytes, but also at much lower levels in different cancer entities...
  46. van Beek Harmsen B, Bekedam M, Feenstra H, Visser F, van der Laarse W. Determination of myoglobin concentration and oxidative capacity in cryostat sections of human and rat skeletal muscle fibres and rat cardiomyocytes. Histochem Cell Biol. 2004;121:335-42 pubmed
    b>Myoglobin plays various roles in oxygen supply to muscle mitochondria...
  47. Jeffreys A, Wilson V, Blanchetot A, Weller P, Geurts van Kessel A, Spurr N, et al. The human myoglobin gene: a third dispersed globin locus in the human genome. Nucleic Acids Res. 1984;12:3235-43 pubmed
    Human myoglobin is specified by a single gene...
  48. D Aprile A, Scrima R, Quarato G, Tataranni T, Falzetti F, Di Ianni M, et al. Hematopoietic stem/progenitor cells express myoglobin and neuroglobin: adaptation to hypoxia or prevention from oxidative stress?. Stem Cells. 2014;32:1267-77 pubmed publisher
    ..In this study, we provide for the first time novel functional and molecular evidences that human HSPCs express myoglobin (Mb) at level comparable with that of a muscle-derived cell line...
  49. Cui T, Jiang M. Myoglobin A79G polymorphism association with exercise-induced skeletal muscle damage. Genet Mol Res. 2016;15: pubmed publisher
    We assessed the role of A79G, a polymorphism of the myoglobin gene (MB), in susceptibility to exercise-induced skeletal muscle damage...
  50. Alshammari T, Alshammari M, Nenov M, Hoxha E, Cambiaghi M, Marcinno A, et al. Genetic deletion of fibroblast growth factor 14 recapitulates phenotypic alterations underlying cognitive impairment associated with schizophrenia. Transl Psychiatry. 2016;6:e806 pubmed publisher
    ..of FGF14 and genes enriched within the GABAergic pathway along with correlatively decreased expression of FGF14, PVALB, GAD67 and VGAT in the disease context...
  51. Zhu J, Zou N, Mao H, Wang P, Zhu D, Ji H, et al. Evaluation of a modified lateral flow immunoassay for detection of high-sensitivity cardiac troponin I and myoglobin. Biosens Bioelectron. 2013;42:522-5 pubmed publisher
    ..test modified with nanoparticles for combined detection of high-sensitivity cardiac troponin I (hs-cTnI) and myoglobin with the aim of excluding acute myocardial infarction (AMI)...
  52. Robach P, Cairo G, Gelfi C, Bernuzzi F, Pilegaard H, Vigano A, et al. Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle. Blood. 2007;109:4724-31 pubmed
    ..for oxygen transport because it is incorporated in the heme of the oxygen-binding proteins hemoglobin and myoglobin. An interaction between iron homeostasis and oxygen regulation is further suggested during hypoxia, in which ..
  53. Koh D, Sng J. HDAC1 negatively regulates Bdnf and Pvalb required for parvalbumin interneuron maturation in an experience-dependent manner. J Neurochem. 2016;139:369-380 pubmed publisher
    ..deacetylases, negatively regulate the expression of brain-derived neurotrophic factor (Bdnf) and parvalbumin (Pvalb) genes during development, which are required for the maturation of parvalbumin interneurons...
  54. Furuhashi M, Ura N, Hasegawa K, Tsuchihashi K, Nakata T, Shimamoto K. Utility of serum ratio of heart-type fatty acid-binding protein to myoglobin for cardiac damage regardless of renal dysfunction. Circ J. 2004;68:656-9 pubmed
    The serum ratio of heart-type fatty acid-binding protein to myoglobin (F/M) has been shown to be a new marker for cardiac damage and volume overload in hemodialysis patients...
  55. Takata T, Miyaishi S, Yamamoto Y, Inagaki S, Yoshitome K, Ishikawa T, et al. Allele frequencies of single nucleotide polymorphisms in the second exon of the myoglobin gene among the Japanese. Hum Biol. 2002;74:317-20 pubmed
    The difference in the allele frequencies of two single nucleotide polymorphisms (SNPs) in the second exon of the myoglobin gene between Japanese and other populations is reported...
  56. Taghdisi S, Danesh N, Ramezani M, Emrani A, Abnous K. A novel electrochemical aptasensor based on Y-shape structure of dual-aptamer-complementary strand conjugate for ultrasensitive detection of myoglobin. Biosens Bioelectron. 2016;80:532-537 pubmed publisher
    Monitoring of myoglobin (Mb) in human blood serum is highly in demand for early diagnosis of acute myocardial infarction (AMI)...
  57. Gussoni M, Scorciapino M, Vezzoli A, Anedda R, Greco F, Ceccarelli M, et al. Structural characterization of recombinant human myoglobin isoforms by (1)H and (129)Xe NMR and molecular dynamics simulations. Biochim Biophys Acta. 2011;1814:1919-29 pubmed publisher
    b>Myoglobin (Mb), the main cytosolic oxygen storage/deliver protein, is also known to interact with different small ligands exerting other fundamental physiological roles. In Humans up to five different Mb isoforms are present...
  58. Forsman M, Pääkkönen V, Tjäderhane L, Vuoristo J, Kallioinen L, Salo T, et al. The expression of myoglobin and ROR2 protein in Dupuytren's disease. J Surg Res. 2008;146:271-5 pubmed
    ..At least an 8-fold change in gene expression was found with 127 genes, including a 90-fold down-regulation of myoglobin and a 14-fold up-regulation of tyrosine kinase-like orphan receptor 2 (= ROR2) from absent to present during the ..
  59. Lundholm K, Schersten T. Protein synthesis in isolated human skeletal muscle tissue: evaluation of an experimental model. Clin Sci (Lond). 1979;57:221-3 pubmed
    Amino acids were incorporated into soluble proteins, myosin and myoglobin at constant rates for at least 4 h on incubation of isolated human skeletal muscle fibres...
  60. Weber M, Kinscherf R, Krakowski Roosen H, Aulmann M, Renk H, Künkele A, et al. Myoglobin plasma level related to muscle mass and fiber composition: a clinical marker of muscle wasting?. J Mol Med (Berl). 2007;85:887-96 pubmed
    ..The present study evaluated the potential of myoglobin (MG) plasma levels to indicate wasting of large locomotor muscles and, moreover, to reflect the loss of MG-rich ..
  61. Oleksiewicz U, Daskoulidou N, Liloglou T, Tasopoulou K, Bryan J, Gosney J, et al. Neuroglobin and myoglobin in non-small cell lung cancer: expression, regulation and prognosis. Lung Cancer. 2011;74:411-8 pubmed publisher
    ..The status of neuroglobin and myoglobin is largely unknown in human malignancies, including lung cancer...
  62. Romero Herrera A, Lehmann H. The myoglobin of primates. II. Pan Troglodytes (chimpanzee). Biochim Biophys Acta. 1972;278:62-7 pubmed
  63. Vatansever S, Akkaya V, Erk O, Ozturk S, Karan M, Salmayenli N, et al. The diagnostic value of troponin T and myoglobin levels in acute myocardial infarction: a study in Turkish patients. J Int Med Res. 2003;31:76-83 pubmed
    This study compares the diagnostic value of troponin T (TnT) and myoglobin with creatinine kinase (CK) for myocardial infarction (MI) in a tertiary care centre in a developing nation...
  64. Yamamoto M, Komiyama N, Koizumi T, Nameki M, Yamamoto Y, Toyoda T, et al. Usefulness of rapid quantitative measurement of myoglobin and troponin T in early diagnosis of acute myocardial infarction. Circ J. 2004;68:639-44 pubmed
    New equipment, the Cardiac Reader(TM), which can measure blood concentrations of troponin T (T) and myoglobin (M) in only 15 min at the bedside was evaluated for early diagnosis of acute myocardial infarction (AMI)...
  65. Granata A, Roncone R, Monzani E, Casella L. Tyrosinase-generated quinones induce covalent modification, unfolding, and aggregation of human holo-myoglobin. Biomacromolecules. 2007;8:3214-23 pubmed
    The present study describes the pattern of protein modification undergone by human holo-myoglobin by reactive fluoroquinones enzymatically produced by oxidation of 3-fluorophenol in mild conditions (pH 7.4, 25 degrees C)...
  66. Akaboshi E. Cloning of the human myoglobin gene. Gene. 1985;33:241-9 pubmed
    Genomic clones that contain the human myoglobin gene were isolated by cross-hybridization to the porcine myoglobin cDNA from human genomic libraries. The myoglobin gene is about 10...
  67. Suzuki T, Imai K. Evolution of myoglobin. Cell Mol Life Sci. 1998;54:979-1004 pubmed
    The distribution, physiological function, amino acid sequence and gene structure of myoglobin and myoglobin-like proteins from various taxa are summarized, and their evolution is discussed...
  68. Phillips E, Schreiner C, Hasenstaub A. Cortical Interneurons Differentially Regulate the Effects of Acoustic Context. Cell Rep. 2017;20:771-778 pubmed publisher
    ..In contrast, inactivating parvalbumin-positive (Pvalb+) interneurons strengthens forward suppression and alters its frequency dependence...
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    To prepare the monoclonal antibody (mAb) against human myoglobin (MYO) of high titer and specificity and develop double-antibody sandwich ELISA for detecting MYO in human serum samples...
  70. Shumyantseva V, Bulko T, Sigolaeva L, Kuzikov A, Archakov A. Electroanalysis of myoglobin based on electropolymerized molecularly imprinted polymer poly-o-phenylenediamine and carbon nanotubes/screen printed electrode. Dokl Biochem Biophys. 2016;468:213-6 pubmed publisher
    Electroanalysis of myoglobin as a marker of acute myocardial infarction by means of screenprinted electrodes modified with multiwalled carbon nanotubes and polymeric artificial antibodies is developed...
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    The entry of a water molecule into the distal heme pocket of pentacoordinate heme proteins such as myoglobin and the alpha,beta chains of hemoglobin can be detected by time-resolved spectroscopy in the heme visible bands after photolysis ..
  72. Jung E, Moffat J, Liu J, DRAVID S, Gurumurthy C, Kim W. Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior. Nat Neurosci. 2017;20:1694-1707 pubmed publisher
    ..suppressed histone H3 lysine 9 acetylation (H3K9ac) overall and particularly reduced H3K9ac of the Pvalb promoter, resulting in decreased transcription...
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    Femtosecond to nanosecond dynamics of O(2) rebinding to human WT myoglobin and its mutants, V68F and I107F, have been studied by using transient absorption. The results are compared with NO rebinding...
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  76. Nasgashio R, Sato Y, Matsumoto T, Kageyama T, Hattori M, Iyoda A, et al. The balance between the expressions of hASH1 and HES1 differs between large cell neuroendocrine carcinoma and small cell carcinoma of the lung. Lung Cancer. 2011;74:405-10 pubmed publisher
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    ..The results are discussed in terms of the sequence regions that are more important than others in determining the amyloid aggregation process. ..
  78. Balobanov V, Il ina N, Katina N, Kashparov I, Dolgikh D, Bychkova V. [Kinetics of interaction between apomyoglobin and phospholipid membrane]. Mol Biol (Mosk). 2010;44:708-17 pubmed
    ..The importance of the obtained results for the folding of membrane proteins and the choice of the pathway for target delivery of protein drugs are discussed. ..
  79. Nagao S, Asami O, Yasui H, Hirota S. Efficient reduction of Cys110 thiyl radical by glutathione in human myoglobin. Biochim Biophys Acta. 2011;1814:480-6 pubmed publisher
    Human myoglobin (hMb) possesses a cysteine (Cys) residue which is rare among mammalian Mbs...
  80. Witting P, Douglas D, Mauk A. Reaction of human myoglobin and H2O2. Involvement of a thiyl radical produced at cysteine 110. J Biol Chem. 2000;275:20391-8 pubmed
    The human myoglobin (Mb) sequence is similar to other mammalian Mb sequences, except for a unique cysteine at position 110...
  81. Boulton F, Huntsman R, Romero Herrera A, Lorkin P, Lehmann H. The third variant of human myoglobin showing an unusual amino acid substitution: 138(H16)arginine--tryptophan. Biochim Biophys Acta. 1971;229:716-9 pubmed
  82. Kelley W, Lockwood C, Cervelli D, Sterner J, Scott M, Duh S, et al. Cardiovascular disease testing on the Dimension Vista system: biomarkers of acute coronary syndromes. Clin Biochem. 2009;42:1444-51 pubmed publisher
    ..The Dimension Vista cTnI, CK-MB, MYO, NTproBNP, and hsCRP methods demonstrate acceptable performance characteristics for use as an aid in the diagnosis and risk assessment of patients presenting with suspected acute coronary syndromes. ..
  83. Behnes C, Bedke J, Schneider S, Küffer S, Strauss A, Bremmer F, et al. Myoglobin expression in renal cell carcinoma is regulated by hypoxia. Exp Mol Pathol. 2013;95:307-12 pubmed publisher
    b>Myoglobin is a member of the hemoprotein superfamily, which additionally includes hemoglobin, neuroglobin and cytoglobin. Cytoplasmic localized myoglobin functions as a radical scavenger and prevents hypoxia...
  84. Rayner B, Hua S, Sabaretnam T, Witting P. Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle. Biochem J. 2009;423:169-77 pubmed publisher
    Mb (myoglobin) is a haemoprotein present in cardiac, skeletal and smooth muscle and is primarily responsible for the storage and 'facilitated transfer' of molecular oxygen from the cell membrane to mitochondria...
  85. Qiu Y, Sutton L, Riggs A. Identification of myoglobin in human smooth muscle. J Biol Chem. 1998;273:23426-32 pubmed
    b>Myoglobin (Mb) has been believed to be absent generally from mammalian smooth muscle tissue...
  86. Boulton F, Huntsman R, Romero Herrera A, Lorkin P, Lehmann H. A human myoglobin variant 133 (H-10)lysine--asparagine. Biochim Biophys Acta. 1971;229:871-6 pubmed
  87. Premru V, Kovac J, Ponikvar R. Use of myoglobin as a marker and predictor in myoglobinuric acute kidney injury. Ther Apher Dial. 2013;17:391-5 pubmed publisher
    ..as a marker in the assessment of rhabdomyolysis and acute myoglobinuric kidney injury (Mb-AKI), while the use of myoglobin is much less explored in this respect...
  88. Kristiansen G, Rose M, Geisler C, Fritzsche F, Gerhardt J, Luke C, et al. Endogenous myoglobin in human breast cancer is a hallmark of luminal cancer phenotype. Br J Cancer. 2010;102:1736-45 pubmed publisher
    We aimed to clarify the incidence and the clinicopathological value of non-muscle myoglobin (Mb) in a large cohort of non-invasive and invasive breast cancer cases...
  89. Meller S, Bicker A, Montani M, Ikenberg K, Rostamzadeh B, Sailer V, et al. Myoglobin expression in prostate cancer is correlated to androgen receptor expression and markers of tumor hypoxia. Virchows Arch. 2014;465:419-27 pubmed publisher
    Recent studies identified unexpected expression and transcriptional complexity of the hemoprotein myoglobin (MB) in human breast cancer but its role in prostate cancer is still unclear...