MyoD

Summary

Gene Symbol: MyoD
Description: myogenic differentiation 1
Alias: MYF3, MYOD, PUM, bHLHc1, myoblast determination protein 1, class C basic helix-loop-helix protein 1, myf-3, myogenic factor 3
Species: human
Products:     MyoD

Top Publications

  1. Berkes C, Tapscott S. MyoD and the transcriptional control of myogenesis. Semin Cell Dev Biol. 2005;16:585-95 pubmed
    The basic helix-loop-helix myogenic regulatory factors MyoD, Myf5, myogenin and MRF4 have critical roles in skeletal muscle development...
  2. Weintraub H, Davis R, Tapscott S, Thayer M, Krause M, Benezra R, et al. The myoD gene family: nodal point during specification of the muscle cell lineage. Science. 1991;251:761-6 pubmed
    The myoD gene converts many differentiated cell types into muscle. MyoD is a member of the basic-helix-loop-helix family of proteins; this 68-amino acid domain in MyoD is necessary and sufficient for myogenesis...
  3. Fulco M, Schiltz R, Iezzi S, King M, Zhao P, Kashiwaya Y, et al. Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol Cell. 2003;12:51-62 pubmed
    ..Sir2 forms a complex with the acetyltransferase PCAF and MyoD and, when overexpressed, retards muscle differentiation...
  4. Caretti G, Di Padova M, Micales B, Lyons G, Sartorelli V. The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. Genes Dev. 2004;18:2627-38 pubmed
    ..Upon gene activation, Ezh2, HDAC1, and YY1 dissociated from muscle loci, H3-K27 became hypomethylated and MyoD and SRF were recruited to the chromatin...
  5. Lassar A, Buskin J, Lockshon D, Davis R, Apone S, Hauschka S, et al. MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer. Cell. 1989;58:823-31 pubmed
    b>MyoD is a skeletal muscle-specific protein that is able to induce myogenesis in a wide variety of cell types...
  6. Sartorelli V, Puri P, Hamamori Y, Ogryzko V, Chung G, Nakatani Y, et al. Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program. Mol Cell. 1999;4:725-34 pubmed
    ..They are both required for MyoD activity and muscle differentiation...
  7. Polesskaya A, Duquet A, Naguibneva I, Weise C, Vervisch A, Bengal E, et al. CREB-binding protein/p300 activates MyoD by acetylation. J Biol Chem. 2000;275:34359-64 pubmed
    The myogenic protein MyoD requires two nuclear histone acetyltransferases, CREB-binding protein (CBP)/p300 and PCAF, to transactivate muscle promoters. MyoD is acetylated by PCAF in vitro, which seems to increase its affinity for DNA...
  8. McKinsey T, Zhang C, Olson E. Control of muscle development by dueling HATs and HDACs. Curr Opin Genet Dev. 2001;11:497-504 pubmed
    ..The MyoD and MEF2 families of transcription factors act cooperatively to regulate the expression of skeletal muscle-specific ..
  9. Puri P, Iezzi S, Stiegler P, Chen T, Schiltz R, Muscat G, et al. Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis. Mol Cell. 2001;8:885-97 pubmed
    We describe a functional and biochemical link between the myogenic activator MyoD, the deacetylase HDAC1, and the tumor suppressor pRb...

More Information

Publications132 found, 100 shown here

  1. Hiranuma C, Kawakami K, Oyama K, Ota N, Omura K, Watanabe G. Hypermethylation of the MYOD1 gene is a novel prognostic factor in patients with colorectal cancer. Int J Mol Med. 2004;13:413-7 pubmed
    ..In addition, quantitative methylation analysis by MethyLight is encouraged for other genes showing age-related and non-cancer-specific methylation. ..
  2. Mal A. Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation. EMBO J. 2006;25:3323-34 pubmed
    ..I report Suv39h1 interaction with myogenic regulator MyoD in proliferating muscle cells and its HMT activity, which is associated with MyoD, diminishes as differentiation ..
  3. Yahi H, Fritsch L, Philipot O, Guasconi V, Souidi M, Robin P, et al. Differential cooperation between heterochromatin protein HP1 isoforms and MyoD in myoblasts. J Biol Chem. 2008;283:23692-700 pubmed publisher
    ..In this system, terminal differentiation is initiated by the transcription factor MyoD, whose target genes remain mainly silent until myoblasts are induced to differentiate...
  4. Collins C, Gnocchi V, White R, Boldrin L, Perez Ruiz A, Relaix F, et al. Integrated functions of Pax3 and Pax7 in the regulation of proliferation, cell size and myogenic differentiation. PLoS ONE. 2009;4:e4475 pubmed publisher
    ..Similarly to the effects of Pax7, retroviral expression of Pax3 increases levels of Myf5 mRNA and MyoD protein, but does not result in sustained inhibition of myogenic differentiation...
  5. Fu D, Lala Tabbert N, Lee H, Wiper Bergeron N. Mdm2 promotes myogenesis through the ubiquitination and degradation of CCAAT/enhancer-binding protein β. J Biol Chem. 2015;290:10200-7 pubmed publisher
    ..and acts to maintain the undifferentiated state by stimulating Pax7 expression and by triggering a decrease in MyoD protein expression...
  6. Osborn D, Li K, Hinits Y, Hughes S. Cdkn1c drives muscle differentiation through a positive feedback loop with Myod. Dev Biol. 2011;350:464-75 pubmed publisher
    ..myogenesis in the vertebrate somite, in part by raising the activity of muscle regulatory factors (MRFs) of the Myod family above a threshold. Hh is known to enhance MRF expression...
  7. González N, Moresco J, Cabezas F, de la Vega E, Bustos F, Yates J, et al. Ck2-Dependent Phosphorylation Is Required to Maintain Pax7 Protein Levels in Proliferating Muscle Progenitors. PLoS ONE. 2016;11:e0154919 pubmed publisher
    ..cell fate is influenced by a functional interaction between the transcription factor Pax7 and members of the MyoD family of muscle regulatory factors...
  8. Barzilai Tutsch H, Bodanovsky A, Maimon H, Pines M, Halevy O. Halofuginone promotes satellite cell activation and survival in muscular dystrophies. Biochim Biophys Acta. 2016;1862:1-11 pubmed publisher
    ..mice increased BrdU incorporation at as early as 18h of incubation, as well as phospho-histone H3 (PHH3) and MyoD protein expression in the attached satellite cells, while having no apparent effect on myofibers derived from wild-..
  9. Zhang Z, Li J, Guan D, Liang C, Zhuo Z, Liu J, et al. Long Noncoding RNA lncMUMA Reverses Established Skeletal Muscle Atrophy following Mechanical Unloading. Mol Ther. 2018;26:2669-2680 pubmed publisher
    ..promoted myogenic differentiation by functioning as a miR-762 sponge to regulate the core myogenic regulator MyoD in vitro...
  10. Janesick A, Tang W, Shioda T, Blumberg B. RARγ is required for mesodermal gene expression prior to gastrulation in Xenopus. Development. 2018;145: pubmed publisher
    ..RARγ1 knockdown obliterates somite boundaries, and causes loss of Myod protein in the presomitic mesoderm, but ectopic, persistent expression of Myod protein in the trunk...
  11. Feng Q, Jagannathan S, Bradley R. The RNA Surveillance Factor UPF1 Represses Myogenesis via Its E3 Ubiquitin Ligase Activity. Mol Cell. 2017;67:239-251.e6 pubmed publisher
    ..UPF1 promotes the decay of MYOD protein, a transcription factor that is a master regulator of myogenesis, while leaving MYOD mRNA stability ..
  12. Bustos F, de la Vega E, Cabezas F, Thompson J, Cornelison D, Olwin B, et al. NEDD4 Regulates PAX7 Levels Promoting Activation of the Differentiation Program in Skeletal Muscle Precursors. Stem Cells. 2015;33:3138-51 pubmed publisher
    ..and maintenance through various mechanisms, including repressing the activity of the muscle regulatory factor MyoD. Hence, Pax7-to-MyoD protein ratios can determine maintenance of the committed-undifferentiated state or activation ..
  13. Tan S, Li J, Chen X, Zhang W, Zhang D, Zhang C, et al. Small molecule inhibitor of myogenic microRNAs leads to a discovery of miR-221/222-myoD-myomiRs regulatory pathway. Chem Biol. 2014;21:1265-1270 pubmed publisher
    ..We report here a miR-221/222-myoD-myomiRs regulatory pathway revealed by using a small-molecule probe that selectively inhibits myomiRs including miR-..
  14. Hwang S, Kang Y, Sung B, Kim M, Kim D, Lee Y, et al. Folic acid promotes the myogenic differentiation of C2C12 murine myoblasts through the Akt signaling pathway. Int J Mol Med. 2015;36:1073-80 pubmed publisher
    ..marker, myosin heavy chain (MyHC), as well as those of the myogenic regulatory factors (MRFs), MyoD and myogenin, were increased in the folic acid-treated myotubes during myogenic differentiation...
  15. Lima A, Martinez P, Damatto R, Cezar M, Guizoni D, Bonomo C, et al. Heart failure-induced diaphragm myopathy. Cell Physiol Biochem. 2014;34:333-45 pubmed publisher
    ..JNK and p38 did not differ between groups. Expression of NF-κB and the myogenic regulatory factors MyoD, myogenin, and MRF4 was similar between groups...
  16. Mofarrahi M, McClung J, Kontos C, Davis E, Tappuni B, Moroz N, et al. Angiopoietin-1 enhances skeletal muscle regeneration in mice. Am J Physiol Regul Integr Comp Physiol. 2015;308:R576-89 pubmed publisher
    ..The latter effect was associated with significant upregulation of the expression of the myogenic regulatory factors MyoD and Myogenin and certain genes involved in cell cycle regulation...
  17. Markworth J, Mitchell C, D Souza R, Aasen K, Durainayagam B, Mitchell S, et al. Arachidonic acid supplementation modulates blood and skeletal muscle lipid profile with no effect on basal inflammation in resistance exercise trained men. Prostaglandins Leukot Essent Fatty Acids. 2018;128:74-86 pubmed publisher
    ..In muscle, ARA supplementation increased mRNA expression of the myogenic regulatory factors; MyoD and myogenin, but had no effect on a range of immune cell markers or inflammatory cytokines...
  18. Spassov A, Gredes T, Gedrange T, Lucke S, Pavlovic D, Kunert Keil C. The expression of myogenic regulatory factors and muscle growth factors in the masticatory muscles of dystrophin-deficient (mdx) mice. Cell Mol Biol Lett. 2011;16:214-25 pubmed publisher
    ..The finding of gender-related differences in the mRNA expression of the examined factors may indicate the importance of hormonal influences on muscle regeneration. ..
  19. He L, Tian X, Yan C, Liu D, Wang S, Han Y. Nicotine promotes the differentiation of C2C12 myoblasts and improves skeletal muscle regeneration in obese mice. Biochem Biophys Res Commun. 2019;: pubmed publisher
    ..showed that nicotine promoted C2C12 myoblast differentiation by upregulating myogenic regulatory factors, including MyoD and Myogenin...
  20. Soundharrajan I, Kim D, Srisesharam S, Kuppusamy P, Sivanesan R, Choi K. Limonene promotes osteoblast differentiation and 2-deoxy-d-glucose uptake through p38MAPK and Akt signaling pathways in C2C12 skeletal muscle cells. Phytomedicine. 2018;45:41-48 pubmed publisher
    ..calcium depositions and the expression of osteogenic specific genes such as Myogenin, Myogenic differentiation 1 (MyoD), ALP, Run-related transcription factor 2(RUNX2), osteocalcin (OCN)...
  21. Redshaw Z, Sweetman D, Loughna P. The effects of age upon the expression of three miRNAs in muscle stem cells isolated from two different porcine skeletal muscles. Differentiation. 2014;88:117-23 pubmed publisher
    ..The levels of expression of Pax7 and the myogenic regulatory factors MyoD and myogenin were also measured...
  22. Bai X, Wang X, Tang B, Shi H, Boireau P, Rosenthal B, et al. The roles of supernatant of macrophage treated by excretory-secretory products from muscle larvae of Trichinella spiralis on the differentiation of C2C12 myoblasts. Vet Parasitol. 2016;231:83-91 pubmed publisher
    ..The results showed that the expression of Myogenic Regulatory Factors (MRFs) MyoD and myogenin, myosin heavy chain (MyHC), and the p21 cyclin-dependent kinase inhibitor were reduced in CM treated ..
  23. Tamura K, Takayama S, Ishii T, Mawaribuchi S, Takamatsu N, Ito M. Apoptosis and differentiation of Xenopus tail-derived myoblasts by thyroid hormone. J Mol Endocrinol. 2015;54:185-92 pubmed publisher
    ..Interestingly, the T3-treatment also increased myoD transcripts, but decreased the amounts of myogenin mRNA and myosin heavy chain...
  24. Dukes A, Davis C, El Refaey M, Upadhyay S, Mork S, Arounleut P, et al. The aromatic amino acid tryptophan stimulates skeletal muscle IGF1/p70s6k/mTor signaling in vivo and the expression of myogenic genes in vitro. Nutrition. 2015;31:1018-24 pubmed publisher
    ..amino acid affected proliferation of myoprogenitors, but Trp increased the expression of the myogenic markers MyoD, myogenin, and myosin heavy chain...
  25. Harding R, Velleman S. MicroRNA regulation of myogenic satellite cell proliferation and differentiation. Mol Cell Biochem. 2016;412:181-95 pubmed publisher
    ..of these miRNAs differentially affected the expression of syndecan-4, glypican-1, and myogenic regulatory factors myoD and myogenin. Inhibition of miR-16 reduced proliferation of satellite cells at 72 h...
  26. Su Z, Hu L, Cheng J, Klein J, Hassounah F, Cai H, et al. Acupuncture plus low-frequency electrical stimulation (Acu-LFES) attenuates denervation-induced muscle atrophy. J Appl Physiol (1985). 2016;120:426-36 pubmed publisher
    ..The abundances of Pax7, MyoD, myogenin, and embryonic myosin heavy chain were significantly increased by Acu-LFES in both normal and denervated ..
  27. Yi H, Forsythe S, He Y, Liu Q, Xiong G, Wei S, et al. Tissue-specific extracellular matrix promotes myogenic differentiation of human muscle progenitor cells on gelatin and heparin conjugated alginate hydrogels. Acta Biomater. 2017;62:222-233 pubmed publisher
    ..and immunocytochemical analyses, the Alg-G-H-ECM predominantly enhanced expression of skeletal myogenesis markers (MyoD, Myf5, Myogenin, Desmin and Myosin) and myotube formation in hSMPCs...
  28. Rowlands D, Nelson A, Raymond F, Metairon S, Mansourian R, Clarke J, et al. Protein-leucine ingestion activates a regenerative inflammo-myogenic transcriptome in skeletal muscle following intense endurance exercise. Physiol Genomics. 2016;48:21-32 pubmed publisher
    ..Further cellular and translational research is warranted to validate amino acid-mediated myeloid and myocellular mechanisms within skeletal-muscle functional plasticity. ..
  29. Aurade F, Pinset C, Chafey P, Gros F, Montarras D. Myf5, MyoD, myogenin and MRF4 myogenic derivatives of the embryonic mesenchymal cell line C3H10T1/2 exhibit the same adult muscle phenotype. Differentiation. 1994;55:185-92 pubmed
    ..mesenchymal cell line C3H10T1/2 have revealed the potential that the four regulatory factors belonging to the MyoD family have to activate myogenesis...
  30. Mozdziak P, Greaser M, Schultz E. Myogenin, MyoD, and myosin expression after pharmacologically and surgically induced hypertrophy. J Appl Physiol (1985). 1998;84:1359-64 pubmed
    The relationship between myogenin or MyoD expression and hypertrophy of the rat soleus produced either by clenbuterol and 3,3', 5-triiodo-L-thyronine (CT) treatment or by surgical overload was examined...
  31. Israeli D, Benchaouir R, Ziaei S, Rameau P, Gruszczynski C, Peltekian E, et al. FGF6 mediated expansion of a resident subset of cells with SP phenotype in the C2C12 myogenic line. J Cell Physiol. 2004;201:409-19 pubmed
    ..Expression of MyoD and myogenin, but not of Myf5, was abrogated in FGF6 engineered mpc. These effects were reversed by FGF inhibitors...
  32. Weidmann C, Qiu C, Arvola R, Lou T, Killingsworth J, Campbell Z, et al. Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio. elife. 2016;5: pubmed publisher
    ..We investigated combinatorial translational regulation by Drosophila Pumilio (Pum) and Nanos (Nos), which control development, fertility, and neuronal functions...
  33. Akiyama T, Sato S, Chikazawa Nohtomi N, Soma A, Kimura H, Wakabayashi S, et al. Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing. Sci Rep. 2018;8:1189 pubmed publisher
    ..This rapid and direct differentiation method may have potential applications in regenerative medicine and disease therapeutics for muscle disorders such as muscular dystrophy. ..
  34. Ye F, Mathur S, Liu M, Borst S, Walter G, Sweeney H, et al. Overexpression of insulin-like growth factor-1 attenuates skeletal muscle damage and accelerates muscle regeneration and functional recovery after disuse. Exp Physiol. 2013;98:1038-52 pubmed publisher
    ..reambulation), paired-box transcription factor 7 (36% at 5 days), embryonic myosin (37% at 10 days) and elevated MyoD mRNA (7-fold at 2 days) in IGF-1-injected limbs (P<0.05)...
  35. D Souza D, Trajcevski K, Al Sajee D, Wang D, Thomas M, Anderson J, et al. Diet-induced obesity impairs muscle satellite cell activation and muscle repair through alterations in hepatocyte growth factor signaling. Physiol Rep. 2015;3: pubmed publisher
    ..injury displayed attenuated muscle regeneration, as indicated by prolonged necrosis, delayed expression of MyoD and Myogenin, elevated collagen content, and persistent embryonic myosin heavy chain expression...
  36. Blanc R, Vogel G, Li X, Yu Z, Li S, Richard S. Arginine Methylation by PRMT1 Regulates Muscle Stem Cell Fate. Mol Cell Biol. 2017;37: pubmed publisher
    ..regulated process controlled by a genetic cascade involving determinant transcription factors such as Pax7, Myf5, MyoD, and MyoG...
  37. Wei X, Li H, Zhang B, Li C, Dong D, Lan X, et al. miR-378a-3p promotes differentiation and inhibits proliferation of myoblasts by targeting HDAC4 in skeletal muscle development. RNA Biol. 2016;13:1300-1309 pubmed
    ..Overexpression of miR-378a-3p increased the expression of MyoD and MHC in C2C12 myoblasts both at the level of mRNA and protein, confirming that miR-378a-3p promoted muscle cell ..
  38. Chen K, Chang Y, Yeh C, Lian Y, Chan M, Kao C, et al. SH2B1 modulates chromatin state and MyoD occupancy to enhance expressions of myogenic genes. Biochim Biophys Acta Gene Regul Mech. 2017;1860:270-281 pubmed publisher
    ..b>MyoD is a key transcription factor during myogenesis...
  39. Khan M, Khan M, Kashiwagi S, Kem W, Yasuhara S, Kaneki M, et al. An ALPHA7 Nicotinic Acetylcholine Receptor Agonist (GTS-21) Promotes C2C12 Myonuclear Accretion in Association with Release of Interleukin-6 (IL-6) and Improves Survival in Burned Mice. Shock. 2017;48:227-235 pubmed publisher
    ..GTS-21 increased MyoD and Pax7 protein expression, myonuclear accretion, and insulin-induced phosphorylation of Akt, GSK-3?, and Glut4 in ..
  40. Liu L, Wang L, Ren Y, Rao X, Yang S. [Retroperitoneal dedifferentiated liposarcoma with rhabdomyoblastic differentiation: a clinicopathological analysis]. Zhonghua Bing Li Xue Za Zhi. 2018;47:94-98 pubmed publisher
  41. Bailey P, Sartorelli V, Hamamori Y, Muscat G. The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function: COUP-TF II directly interacts with p300 and myoD. Nucleic Acids Res. 1998;26:5501-10 pubmed
    ..cells has been demonstrated to inhibit morphological differentiation, and to repress the expression of: (i) the myoD gene family which encodes myogenic basic helix-loop-helix (bHLH) proteins; and (ii) the cell cycle regulator, p21(..
  42. Ruijtenberg S, van den Heuvel S. G1/S Inhibitors and the SWI/SNF Complex Control Cell-Cycle Exit during Muscle Differentiation. Cell. 2015;162:300-313 pubmed publisher
    ..elegans tumor phenotype. Further genetic analyses support that SWI/SNF acts in concert with hlh-1 MyoD, antagonizes Polycomb-mediated transcriptional repression, and suppresses cye-1 Cyclin E transcription to arrest ..
  43. Lee S, Go G, Yoo M, Kim Y, Seo D, Kang J, et al. Peroxisome proliferator-activated receptor ?/? (PPAR?/?) activates promyogenic signaling pathways, thereby promoting myoblast differentiation. Biochem Biophys Res Commun. 2016;470:157-162 pubmed publisher
    ..In addition, GW0742 treatment enhances MyoD-reporter activities...
  44. Kawai M, Ohmori Y, Nishino M, Yoshida M, Tabata K, Hirota D, et al. Determination of cell fate in skeletal muscle following BMP gene transfer by in vivo electroporation. Eur J Histochem. 2017;61:2772 pubmed publisher
    ..Commitment towards either muscle regeneration or induction of ectopic bone formation appears to occur five to seven days after BMP gene transfer. ..
  45. Li H, Yang J, Wei X, Song C, Dong D, Huang Y, et al. CircFUT10 reduces proliferation and facilitates differentiation of myoblasts by sponging miR-133a. J Cell Physiol. 2017;: pubmed publisher
    ..circFUT10 induced bovine primary myoblasts differentiation and increased the expression of MyoD, MyoG and MyhC in mRNA and protein levels...
  46. Malakooti J, Dahdal R, Dudeja P, Layden T, Ramaswamy K. The human Na(+)/H(+) exchanger NHE2 gene: genomic organization and promoter characterization. Am J Physiol Gastrointest Liver Physiol. 2001;280:G763-73 pubmed
    ..contains several potential cis-regulatory elements such as Sp1, early growth response-1, activator protein-2, MyoD, p300, nuclear factor-kappaB, myeloid zinc finger protein-1, caudal-related homeobox (Cdx) gene A, and Cdx protein-..
  47. Kosek D, Kim J, Petrella J, Cross J, Bamman M. Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults. J Appl Physiol (1985). 2006;101:531-44 pubmed
    ..05) as growth among Y (25%) exceeded that of O (4%) men. Myogenin and myogenic differentiation factor D (MyoD) mRNAs increased (P < 0.05) in Y and O, whereas myogenic factor (myf)-5 mRNA increased in Y only (P < 0.05)...
  48. Jung E, Sim Y, Jeong H, Kim S, Yun Y, Song J, et al. Jmjd2C increases MyoD transcriptional activity through inhibiting G9a-dependent MyoD degradation. Biochim Biophys Acta. 2015;1849:1081-94 pubmed publisher
    ..Skeletal muscle cell differentiation requires a family of proteins called myogenic regulatory factors (MRFs) to which MyoD belongs...
  49. Rotterova P, Martinek P, Alaghehbandan R, Prochazkova K, Damjanov I, Rogala J, et al. High-grade renal cell carcinoma with emperipolesis: Clinicopathological, immunohistochemical and molecular-genetic analysis of 14 cases. Histol Histopathol. 2018;33:277-287 pubmed publisher
    ..All RCC cases with prominent emperipolesis fulfilled both morphologic and immunohistochemical diagnostic criteria of high-grade CCRCC. The majority of patients with available follow up information developed metastases. ..
  50. Nederveen J, Joanisse S, Séguin C, Bell K, Baker S, Phillips S, et al. The effect of exercise mode on the acute response of satellite cells in old men. Acta Physiol (Oxf). 2015;215:177-90 pubmed publisher
    ..3 ± 0.1, 24 h: 4.8 ± 0.5 Pax7 + /MyoD+cells/100 fibres) and high-intensity interval exercise (pre: 0.7 ± 0.3, 24 h: 3.1 ± 0...
  51. Li H, Zhang Y, Pan Y, Hui D, Chen J, Jin Y. Clinicopathological analysis of concomitant hepatic embryonal rhabdomyosarcoma and hepatocellular carcinoma. Pathol Res Pract. 2017;213:1014-1018 pubmed publisher
    ..To our knowledge, this is the first case report of ERMS of the liver associated with HCC. The diagnosis can only be made by pathological examination. The primary therapy method for this tumor is operative resection. ..
  52. Onions J, Hermann S, Grundstrom T. A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors. Biochemistry. 2000;39:4366-74 pubmed
  53. Luo W, Li E, Nie Q, Zhang X. Myomaker, Regulated by MYOD, MYOG and miR-140-3p, Promotes Chicken Myoblast Fusion. Int J Mol Sci. 2015;16:26186-201 pubmed publisher
    ..b>MYOD and MYOG, which belong to the family of myogenic regulatory factors, can bind to a conserved E-box located proximal ..
  54. Du J, Zhang Y, Shen L, Luo J, Lei H, Zhang P, et al. Effect of miR-143-3p on C2C12 myoblast differentiation. Biosci Biotechnol Biochem. 2016;80:706-11 pubmed publisher
    ..differentiation and over-expression of miR-143-3p significantly inhibited the relative expression levels of MyoD, MyoG, myf5, and MyHC genes, especially in the later stages of differentiation...
  55. Son Y, Jang E, Kim Y, Lee J. Sulforaphane prevents dexamethasone-induced muscle atrophy via regulation of the Akt/Foxo1 axis in C2C12 myotubes. Biomed Pharmacother. 2017;95:1486-1492 pubmed publisher
    ..by increased muscle specific ubiquitin E3 ligase markers, such as, Atrogin-1 and myostatin, and decreased MyoD in C2C12 myotubes...
  56. Tapscott S, Davis R, Thayer M, Cheng P, Weintraub H, Lassar A. MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts. Science. 1988;242:405-11 pubmed
    ..Genetic analysis maps the MyoD1 gene to mouse chromosome 7 and human chromosome 11. ..
  57. Zhang R, Feng X, Zhan M, Huang C, Chen K, Tang X, et al. Transcription Factor Sp1 Promotes the Expression of Porcine ROCK1 Gene. Int J Mol Sci. 2016;17: pubmed publisher
    ..Overexpression of Sp1 can promote the expression of myogenic differentiation 1(MyoD), myogenin (MyoG), myosin heavy chain (MyHC)...
  58. Bruscoli S, Donato V, Velardi E, Di Sante M, Migliorati G, Donato R, et al. Glucocorticoid-induced leucine zipper (GILZ) and long GILZ inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids. J Biol Chem. 2010;285:10385-96 pubmed publisher
    ..Inhibition of differentiation caused by GILZ/L-GILZ overexpression correlated with inhibition of MyoD function and reduced expression of myogenin...
  59. Szuhai K, de Jong D, Leung W, Fletcher C, Hogendoorn P. Transactivating mutation of the MYOD1 gene is a frequent event in adult spindle cell rhabdomyosarcoma. J Pathol. 2014;232:300-7 pubmed publisher
    ..The p.L122R mutation occurs in the conserved DNA binding domain in MYOD1 and leads to transactivation and MYC-like functions. MYOD1 homozygous mutations are frequent, recurrent and pathognomonic events in adult-type spindle cell RMS. ..
  60. Hoffmann C, Zimmermann A, Hinney A, Volckmar A, Jarrett H, Fromme T, et al. A novel SP1/SP3 dependent intronic enhancer governing transcription of the UCP3 gene in brown adipocytes. PLoS ONE. 2013;8:e83426 pubmed publisher
    ..Data mining demonstrated binding of MyoD and Myogenin to this third element in C2C12 cells, and, furthermore, revealed recruitment of p300...
  61. Saini A, Sharples A, Al Shanti N, Stewart C. Omega-3 fatty acid EPA improves regenerative capacity of mouse skeletal muscle cells exposed to saturated fat and inflammation. Biogerontology. 2017;18:109-129 pubmed publisher
    ..reductions in both creatine kinase activity and gene expression of myogenic factors; IGF-II, IGFBP-5, MyoD and myogenin...
  62. Sun J, Kamei C, Layne M, Jain M, Liao J, Lee M, et al. Regulation of myogenic terminal differentiation by the hairy-related transcription factor CHF2. J Biol Chem. 2001;276:18591-6 pubmed
    ..In transiently transfected 10T1/2 embryonic fibroblasts, CHF2 inhibited MyoD-dependent activation of the myogenin promoter in a dose-dependent fashion...
  63. Ha J, Kwon S, Hwang J, Park D, Kim T, Kang D, et al. Squalene epoxidase plays a critical role in determining pig meat quality by regulating adipogenesis, myogenesis, and ROS scavengers. Sci Rep. 2017;7:16740 pubmed publisher
    ..Additionally, the expression of myogenic marker genes (Myog, Myod, and Myh4) and adipogenic marker genes (Pparg, Cebpa, and Adipoq) was substantially downregulated in cells ..
  64. Casey B, Kollipara R, Pozo K, Johnson J. Intrinsic DNA binding properties demonstrated for lineage-specifying basic helix-loop-helix transcription factors. Genome Res. 2018;: pubmed publisher
    ..These combined properties define a subclass of lineage-specific bHLH factors, and provide context for their central roles in development and disease. ..
  65. Parker L, Caldow M, Watts R, Levinger P, Cameron Smith D, Levinger I. Age and sex differences in human skeletal muscle fibrosis markers and transforming growth factor-β signaling. Eur J Appl Physiol. 2017;117:1463-1472 pubmed publisher
    ..05). There was, however, no difference in the total protein content of myostatin, myoD or myogenin (all p > 0.05), whereas Smad3 protein phosphorylation was 48% lower (p < 0...
  66. Lassar A. Finding MyoD and lessons learned along the way. Semin Cell Dev Biol. 2017;72:3-9 pubmed publisher
    In 1987, Robert Davis, Hal Weintraub and I reported the identification of MyoD, a transcription factor that could reprogram fibroblasts into skeletal muscle cells...
  67. Nishimoto H, Inui A, Ueha T, Inoue M, Akahane S, Harada R, et al. Transcutaneous carbon dioxide application with hydrogel prevents muscle atrophy in a rat sciatic nerve crush model. J Orthop Res. 2017;: pubmed publisher
    ..The mRNA expression of Atrogin-1 and MuRF-1 was lower, mRNA expression of VEGF and myogenin and MyoD was higher in CO2 group at postoperative week 2 compared to the control group.
  68. Hettmer S, Lin M, Tchessalova D, Tortorici S, Castiglioni A, Desai T, et al. Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity. Exp Cell Res. 2016;340:43-52 pubmed publisher
    ..SmoM2 tumors also contain an expanded population of PAX7+ and MyoD+ satellite-like cells with extremely low clonogenic activity...
  69. Saeman M, Despain K, Liu M, Wolf S, Song J. Severe burn increased skeletal muscle loss in mdx mutant mice. J Surg Res. 2016;202:372-9 pubmed publisher
    ..05). Proliferating cell nuclear antigen decreased significantly in mdx mice (P < 0.05). Myogenic markers pax7, myoD, and myogenin increased after burn in both the groups and were higher in mdx mice (P < 0.05)...
  70. Gomez Sanmiguel A, Nieto Bona M, Fernandez Galaz C, Priego T, Martin A, Lopez Calderon A. Melanocortin-4 receptor agonist (RO27-3225) ameliorates soleus but not gastrocnemius atrophy in arthritic rats. J Physiol Pharmacol. 2017;68:191-199 pubmed
    ..is able to prevent the effect of arthritis on the expression of muscle-specific E3 ubiquitin ligases and MyoD in two different muscles, gastrocnemius (a mainly fast type muscle) and soleus (slow type)...
  71. Sung B, Hwang S, Kim M, Kim M, Jeong J, Kim C, et al. Loquat leaf extract enhances myogenic differentiation, improves muscle function and attenuates muscle loss in aged rats. Int J Mol Med. 2015;36:792-800 pubmed publisher
    ..The expression levels of myogenic proteins (MyoD and myogenin) and functional myosin heavy chain (MyHC) were measured by western blot analysis...
  72. Blum R, Vethantham V, Bowman C, Rudnicki M, Dynlacht B. Genome-wide identification of enhancers in skeletal muscle: the role of MyoD1. Genes Dev. 2012;26:2763-79 pubmed publisher
    ..Our studies identified a role for MyoD1 in condition-specific enhancer assembly through recruitment of transcription factors and histone-modifying enzymes that shape muscle differentiation. ..
  73. Dodd R, Sachdeva M, Mito J, Eward W, Brigman B, Ma Y, et al. Myogenic transcription factors regulate pro-metastatic miR-182. Oncogene. 2016;35:1868-75 pubmed publisher
    ..We find that MyoD directly binds the miR-182 promoter to increase miR-182 expression...
  74. Zhang J, Zhao X, Wei Q, Paterson B. Direct inhibition of G(1) cdk kinase activity by MyoD promotes myoblast cell cycle withdrawal and terminal differentiation. EMBO J. 1999;18:6983-93 pubmed
    b>MyoD has been proposed to facilitate terminal myoblast differentiation by binding to and inhibiting phosphorylation of the retinoblastoma protein (pRb)...
  75. Sun L, Liu L, Yang X, Wu Z. Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation. J Cell Sci. 2004;117:3021-9 pubmed
    ..PHB2 acts as a transcriptional repressor in cells. PHB2 interacts with both MyoD and MEF2, and represses both MyoD- and MEF2-dependent gene transcription...
  76. Nicol K, Savell V, Moore J, Teot L, Spunt S, Qualman S. Distinguishing undifferentiated embryonal sarcoma of the liver from biliary tract rhabdomyosarcoma: a Children's Oncology Group study. Pediatr Dev Pathol. 2007;10:89-97 pubmed
    ..Establishing the correct diagnosis of these distinct clinical and pathologic entities is important, as surgery alone may be curative in UESL, whereas initial chemotherapy is often recommended for the treatment of biliary tract RMS. ..
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    ..The SOX6 gene within the bone morphogenic protein pathway could be a candidate for carotid plaque. Larger independent studies are needed to validate these findings. ..
  78. Wang C, Liu W, Liu Z, Chen L, Liu X, Kuang S. Hypoxia Inhibits Myogenic Differentiation through p53 Protein-dependent Induction of Bhlhe40 Protein. J Biol Chem. 2015;290:29707-16 pubmed publisher
    ..binds to the proximal E-boxes of the Myog promoter and reduces the binding affinity and transcriptional activity of MyoD on Myog...
  79. Bakke J, Wright W, Zamora A, Ong S, Wang Y, Hoyer J, et al. Transcription factor ZNF148 is a negative regulator of human muscle differentiation. Sci Rep. 2017;7:8138 pubmed publisher
    ..This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family...
  80. Wu J, He D, Yue B, Zhang C, Fang X, Chen H. miR-101-1 expression pattern in Qinchuan cattle and its role in the regulation of cell differentiation. Gene. 2017;636:64-69 pubmed publisher
    ..the C2C12 myoblast could decrease myotube formation, and the mRNA expression levels of the myogenic marker genes MyOD, MyOG and MyHC were up-regulated. The protein level of MyOD, MyOG and MyHC were also up-regulated...
  81. Yu T, Chang Y, Gao X, Li H, Zhao P. Dynamic Expression and the Role of BDNF in Exercise-induced Skeletal Muscle Regeneration. Int J Sports Med. 2017;: pubmed publisher
    ..05). In addition, serum creatine kinase activity was increased 5d following exercise (p<0.05); expression of MyoD was elevated (p<0...
  82. Batonnet S, Leibovitch M, Tintignac L, Leibovitch S. Critical role for lysine 133 in the nuclear ubiquitin-mediated degradation of MyoD. J Biol Chem. 2004;279:5413-20 pubmed
    The ubiquitin-proteasome system is responsible for the regulation and turnover of the nuclear transcription factor MyoD. The degradation of MyoD can occur via an NH2 terminus-dependent pathway or a lysine-dependent pathway, suggesting ..
  83. Delgado Olguin P, Hernández Hernández J, Salamanca F, Recillas Targa F, Coral Vazquez R. Identification of two E-boxes that negatively modulate the activity of MyoD on the alpha-sarcoglycan core promoter. Biochim Biophys Acta. 2008;1779:74-80 pubmed
    ..regulatory element in the alpha-SG distal promoter including two conserved E-boxes (E1 and E2), which interact with MyoD. We found that E1 and E2 negatively modulate the transactivation potential of MyoD on the alpha-SG core promoter...
  84. Amat R, Planavila A, Chen S, Iglesias R, Giralt M, Villarroya F. SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD. J Biol Chem. 2009;284:21872-80 pubmed publisher
    ..of myogenic factors, such as myocyte enhancer factor 2 (MEF2) and, especially, myogenic determining factor (MyoD)...
  85. Lee S, Yoo M, Go G, Kim D, Choi H, Leem Y, et al. Bakuchiol augments MyoD activation leading to enhanced myoblast differentiation. Chem Biol Interact. 2016;248:60-7 pubmed publisher
    ..b>MyoD family transcription factors function as mater regulators in induction of muscle-specific genes during myoblast ..
  86. Polstein L, Juhas M, Hanna G, Bursac N, Gersbach C. An Engineered Optogenetic Switch for Spatiotemporal Control of Gene Expression, Cell Differentiation, and Tissue Morphogenesis. ACS Synth Biol. 2017;6:2003-2013 pubmed publisher
    ..cell differentiation and reprogramming, we incorporated an engineered form of the master myogenic factor MyoD into this system in multipotent cells...
  87. Paradis F, Wood K, Swanson K, Miller S, McBride B, Fitzsimmons C. Maternal nutrient restriction in mid-to-late gestation influences fetal mRNA expression in muscle tissues in beef cattle. BMC Genomics. 2017;18:632 pubmed publisher
  88. Bosnakovski D, Toso E, Hartweck L, Magli A, Lee H, Thompson E, et al. The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain. J Cell Sci. 2017;130:3685-3697 pubmed publisher
    ..DUX4 has bimodal effects, inhibiting myogenic differentiation and blocking MyoD at low levels of expression, and killing myoblasts at high levels...
  89. Kozakowska M, Pietraszek Gremplewicz K, Ciesla M, Seczyńska M, Bronisz Budzynska I, Podkalicka P, et al. Lack of Heme Oxygenase-1 Induces Inflammatory Reaction and Proliferation of Muscle Satellite Cells after Cardiotoxin-Induced Skeletal Muscle Injury. Am J Pathol. 2018;188:491-506 pubmed publisher
    ..of Hmox1+/+ SCs with monocyte chemoattractant protein-1, IL-6, IL-1β, and is associated with increased MyoD expression, suggesting that Hmox1-/- SCs are shifted toward more differentiated myogenic population...
  90. Zhang L, Gong H, Sun Q, Zhao R, Jia Y. Spermidine-Activated Satellite Cells Are Associated with Hypoacetylation in ACVR2B and Smad3 Binding to Myogenic Genes in Mice. J Agric Food Chem. 2018;66:540-550 pubmed publisher
    ..repressed H3K56ac in the promoter of ACVR2B and lowered the binding affinity of Smad3 to the promoters of Myf5 and MyoD. Altogether, our results indicate that long-term administration of spermidine can activate satellite cells, as well ..
  91. Yuan W, Condorelli G, Caruso M, Felsani A, Giordano A. Human p300 protein is a coactivator for the transcription factor MyoD. J Biol Chem. 1996;271:9009-13 pubmed
    ..protein-binding regions of E1A are required for the repression of muscle gene expression, which is regulated by MyoD family transactivators. This implies that p300 is involved in MyoD-dependent transactivation...
  92. Tamaki T, Uchiyama S, Uchiyama Y, Akatsuka A, Yoshimura S, Roy R, et al. Limited myogenic response to a single bout of weight-lifting exercise in old rats. Am J Physiol Cell Physiol. 2000;278:C1143-52 pubmed
    ..histochemical, and immunohistochemical [anti-5-bromo-2'-deoxyuridine and myogenic determination genes (MyoD)] analyses of whole muscles and analysis of muscle-specific gene expression (MyoD) using Western blotting and RT-..