Gene Symbol: MYO7B
Description: myosin VIIB
Alias: unconventional myosin-VIIb, myosin-VIIb
Bement W, Hasson T, Wirth J, Cheney R, Mooseker M. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. Proc Natl Acad Sci U S A. 1994;91:6549-53 pubmed
..The abundance of myosins suggests that the myosin I vs. myosin II paradigm is inadequate to explain actin-based cellular motility. ..
Chen Z, Hasson T, Zhang D, Schwender B, Derfler B, Mooseker M, et al
. Myosin-VIIb, a novel unconventional myosin, is a constituent of microvilli in transporting epithelia. Genomics. 2001;72:285-96 pubmed
..The human myosin-VIIb (HGMW-approved symbol MYO7B) sequence and exon structure were then deduced from a human BAC clone...
Crawley S, Shifrin D, Grega Larson N, McConnell R, Benesh A, Mao S, et al
. Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion. Cell. 2014;157:433-446 pubmed publisher
..These data reveal an adhesion-based mechanism for brush border assembly and illuminate the basis of intestinal pathology in patients with Usher syndrome. PAPERFLICK: ..
Munir M, Weng L, Tang W, Basu S, Pankow J, Matijevic N, et al
. Genetic markers associated with plasma protein C level in African Americans: the atherosclerosis risk in communities (ARIC) study. Genet Epidemiol. 2014;38:709-13 pubmed publisher
..were significantly and independently associated with protein C levels: rs4321325 in CYP27C1 and rs13419716 in MYO7B. In summary, this first GWA study for plasma protein C levels in African Americans confirms the associations of ..
Li J, He Y, Lu Q, Zhang M. Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link Complex. Dev Cell. 2016;36:179-89 pubmed publisher
..following pairs of interactions: protocadherin 24 and Harmonin (also known as USH1C or AIE-75), Harmonin and myosin VIIb (MYO7B), Harmonin and ANKS4B, and ANKS4B and MYO7B...
Crawley S, Weck M, Grega Larson N, Shifrin D, Tyska M. ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation. Dev Cell. 2016;36:190-200 pubmed publisher
..ANKS4B interacts with USH1C and MYO7B, which link protocadherins to the actin cytoskeleton...
Li J, He Y, Weck M, Lu Q, Tyska M, Zhang M. Structure of Myo7b/USH1C complex suggests a general PDZ domain binding mode by MyTH4-FERM myosins. Proc Natl Acad Sci U S A. 2017;114:E3776-E3785 pubmed publisher
Unconventional myosin 7a (Myo7a), myosin 7b (Myo7b), and myosin 15a (Myo15a) all contain MyTH4-FERM domains (myosin tail homology 4-band 4...
Weck M, Crawley S, Stone C, Tyska M. Myosin-7b Promotes Distal Tip Localization of the Intermicrovillar Adhesion Complex. Curr Biol. 2016;26:2717-2728 pubmed publisher
..Here, we report that the actin-based motor myosin-7b (Myo7b) promotes the accumulation of IMAC components at microvillar tips...