Gene Symbol: MYO1D
Description: myosin ID
Alias: PPP1R108, myr4, unconventional myosin-Id, myosin-I gamma, protein phosphatase 1, regulatory subunit 108
Species: human
Products:     MYO1D

Top Publications

  1. Stone J, Merriman B, Cantor R, Geschwind D, Nelson S. High density SNP association study of a major autism linkage region on chromosome 17. Hum Mol Genet. 2007;16:704-15 pubmed
    ..Nominally significant single SNP and/or haplotype-based association results were detected in 15 genes, of which, MYO1D, ACCN1 and LASP1 stand out as genes with autism risk alleles requiring further study, with potential GRRs in the ..
  2. Lebreton G, Geminard C, Lapraz F, Pyrpassopoulos S, Cerezo D, Speder P, et al. Molecular to organismal chirality is induced by the conserved myosin 1D. Science. 2018;362:949-952 pubmed publisher
    ..In this study, we show that Drosophila myosin 1D (Myo1D) and myosin 1C (Myo1C) are sufficient to generate de novo directional twisting of cells, single organs, or the ..
  3. McAlpine W, Wang K, Choi J, San Miguel M, McAlpine S, Russell J, et al. The class I myosin MYO1D binds to lipid and protects against colitis. Dis Model Mech. 2018;11: pubmed publisher
    Myosin ID (MYO1D) is a member of the class I myosin family...
  4. Benesh A, Nambiar R, McConnell R, Mao S, Tabb D, Tyska M. Differential localization and dynamics of class I myosins in the enterocyte microvillus. Mol Biol Cell. 2010;21:970-8 pubmed publisher
    ..These studies revealed that WT brush borders also contain the short-tailed class I myosin, myosin-1d (Myo1d). Myo1d localizes to the terminal web and striking puncta at the tips of microvilli...
  5. Juan T, Geminard C, Coutelis J, Cerezo D, Polès S, Noselli S, et al. Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry. Nat Commun. 2018;9:1942 pubmed publisher
    ..Here, we show that Myosin1D (Myo1D), a previously identified regulator of Drosophila LR asymmetry, is essential for the formation and function of the ..
  6. Ramadas A, Qureshi A, Dominic N, Botross N, Riad A, Thirunavuk Arasoo V, et al. Socio-demography and medical history as predictors of health-related quality of life of breast cancer survivors. Asian Pac J Cancer Prev. 2015;16:1479-85 pubmed
    ..Survivors' higher personal income (>MYR4,500) was the only significant predictor of social relationship, while age, income more than MYR4,500 and giving ..
  7. Packard M, Jokhi V, Ding B, Ruiz Cañada C, Ashley J, Budnik V. Nucleus to Synapse Nesprin1 Railroad Tracks Direct Synapse Maturation through RNA Localization. Neuron. 2015;86:1015-1028 pubmed publisher
    ..We also show that dNesp1 functions with an unconventional myosin, Myo1D, and that both dNesp1 and Myo1D are mutually required for their localization to immature boutons...
  8. Amcheslavsky A, Wang S, Fogarty C, Lindblad J, Fan Y, Bergmann A. Plasma Membrane Localization of Apoptotic Caspases for Non-apoptotic Functions. Dev Cell. 2018;45:450-464.e3 pubmed publisher
    ..Here, we report that the unconventional myosin, Myo1D, which is known for its involvement in left/right development, is an important mediator of AiP in Drosophila...
  9. Saydmohammed M, Yagi H, Calderon M, Clark M, Feinstein T, Sun M, et al. Vertebrate myosin 1d regulates left-right organizer morphogenesis and laterality. Nat Commun. 2018;9:3381 pubmed publisher
    ..Here, we report that myosin 1d (myo1d) is essential for establishing left-right asymmetry in zebrafish...

More Information


  1. Tingler M, Kurz S, Maerker M, Ott T, Fuhl F, Schweickert A, et al. A Conserved Role of the Unconventional Myosin 1d in Laterality Determination. Curr Biol. 2018;28:810-816.e3 pubmed publisher
    ..In Drosophila, which lacks both cilia and Nodal, the unconventional myosin ID (myo1d) gene controls dextral rotation of chiral organs [6, 7]...
  2. Yamazaki R, Ishibashi T, Baba H, Yamaguchi Y. Knockdown of Unconventional Myosin ID Expression Induced Morphological Change in Oligodendrocytes. ASN Neuro. 2016;8: pubmed
    ..One candidate myosin is unconventional myosin ID (Myo1d) which is distributed throughout central nervous system myelin; however, its function is still ..
  3. Hegan P, Ostertag E, Geurts A, Mooseker M. Myosin Id is required for planar cell polarity in ciliated tracheal and ependymal epithelial cells. Cytoskeleton (Hoboken). 2015;72:503-16 pubmed publisher
    ..Rotational PCP in the multi-ciliated epithelial cells of the trachea is perturbed in rats lacking myosin Id (Myo1d). Myo1d is localized in the F-actin and basal body rich subapical cortex of the ciliated tracheal epithelial cell...
  4. Ngollo M, Lebert A, Daures M, Judes G, Rifai K, Dubois L, et al. Global analysis of H3K27me3 as an epigenetic marker in prostate cancer progression. BMC Cancer. 2017;17:261 pubmed publisher
    ..The analysis identified ALG5, EXOSC8, CBX1, GRID2, GRIN3B, ING3, MYO1D, NPHP3-AS1, MSH6, FBXO11, SND1, SPATS2, TENM4 and TRA2A genes...
  5. Choudhry S, Deshpande A, Qiao L, Beckman K, Sen S, Baskin L. Genome-wide DNA methylation profiling of CpG islands in hypospadias. J Urol. 2012;188:1450-5 pubmed publisher
    ..00001. These CpG sites were in or near the SCARB1, MYBPH, SORBS1, LAMA4, HOXD11, MYO1D, EGFL7, C10orf41, LMAN1L and SULF1 genes...
  6. Rasiah R, Ahmed A, Al Amin A, Chenayah S. Climate change mitigation: comparative assessment of Malaysian and ASEAN scenarios. Environ Sci Pollut Res Int. 2017;24:2632-2642 pubmed publisher
    ..The additional economic output for ASEAN would fall from MYR8.1 billion in 2010 to MYR3.2 billion in 2050 before rising again slightly to MYR4.7 billion in 2110 in the business as usual ASEAN scenario.
  7. Brzeska H, Koech H, Pridham K, Korn E, Titus M. Selective localization of myosin-I proteins in macropinosomes and actin waves. Cytoskeleton (Hoboken). 2016;73:68-82 pubmed publisher
    ..multiple myosin Is, including three short-tailed (Myo1A, Myo1E, Myo1F) and three long-tailed (Myo1B, Myo1C, Myo1D)...
  8. Zhang J, Cheng J, Zeng Z, Wang Y, Li X, Xie Q, et al. Comprehensive profiling of novel microRNA-9 targets and a tumor suppressor role of microRNA-9 via targeting IGF2BP1 in hepatocellular carcinoma. Oncotarget. 2015;6:42040-52 pubmed publisher
    ..IL-6, AP3B1, TC10, ONECUT2, IGF2BP1, MYO1D, and ANXA2 were confirmed to be miR-9 targets in HCC...
  9. Yamazaki R, Baba H, Yamaguchi Y. Unconventional Myosin ID is Involved in Remyelination After Cuprizone-Induced Demyelination. Neurochem Res. 2018;43:195-204 pubmed publisher
    ..Previously, we reported that myosin ID (Myo1d) is distributed in rat CNS myelin and is especially enriched in the outer and inner cytoplasm-containing loops...
  10. Low S, Kuchiba A, Zembutsu H, Saito A, Takahashi A, Kubo M, et al. Genome-wide association study of pancreatic cancer in Japanese population. PLoS ONE. 2010;5:e11824 pubmed publisher
    ..3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer. ..
  11. Yamazaki R, Ishibashi T, Baba H, Yamaguchi Y. Expression of Unconventional Myosin VI in Oligodendrocytes. Neurochem Res. 2017;42:3372-3381 pubmed publisher
    ..Recently, we revealed that one of the unconventional myosins, myosin ID (Myo1d), is expressed in mature oligodendrocytes and is required for myelin-like membrane formation in vitro...
  12. Benesh A, Fleming J, Chiang C, Carter B, Tyska M. Expression and localization of myosin-1d in the developing nervous system. Brain Res. 2012;1440:9-22 pubmed publisher
    ..also identified as a component of myelin-containing subcellular fractions in proteomic studies and mutations in MYO1D have been linked to autism...
  13. Castaldi P, Cho M, San Jose Estepar R, McDonald M, Laird N, Beaty T, et al. Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns. Am J Respir Crit Care Med. 2014;190:399-409 pubmed publisher
    ..Two are novel associations (top single-nucleotide polymorphism rs379123 in MYO1D and rs9590614 in VMA8) located within genes that function in cell-cell signaling and cell migration, and five are ..
  14. Kim S, Lee S, Kim S, Yun C, Kim J, Thomas R, et al. Genetic association of short sleep duration with hypertension incidence--a 6-year follow-up in the Korean genome and epidemiology study. Circ J. 2012;76:907-13 pubmed
    ..This prospective communitywide study showed that premenopausal women with short sleep duration had an increased risk of incident HT, and found associations with specific genomic markers. ..