MYLIP

Summary

Gene Symbol: MYLIP
Description: myosin regulatory light chain interacting protein
Alias: IDOL, MIR, E3 ubiquitin-protein ligase MYLIP, E3 ubiquitin ligase-inducible degrader of the low density lipoprotein receptor, RING-type E3 ubiquitin transferase MYLIP, band 4.1 superfamily member BZF1, cellular modulator of immune recognition (c-MIR), inducible degrader of the LDL-receptor
Species: human
Products:     MYLIP

Top Publications

  1. Lindholm D, Bornhauser B, Korhonen L. Mylip makes an Idol turn into regulation of LDL receptor. Cell Mol Life Sci. 2009;66:3399-402 pubmed publisher
    ..of this receptor come from studies on the ubiquitination and degradation of LDL receptor by the ubiquitin ligase Mylip/Idol that is induced in cells by the nuclear receptor, LXR...
  2. Chasman D, Pare G, Mora S, Hopewell J, Peloso G, Clarke R, et al. Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS Genet. 2009;5:e1000730 pubmed publisher
    ..3), gmpr/mylip (6p22.3), btnl2 (6p21.32), klf14 (7q32.2), 8p23.1, jmjd1c (10q21.3), sbf2 (11p15.4), 12q23...
  3. Chasman D, Giulianini F, MacFadyen J, Barratt B, Nyberg F, Ridker P. Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. Circ Cardiovasc Genet. 2012;5:257-64 pubmed publisher
    ..association with sub-genome-wide significance (P<1×10(-6)) was identified for statin related LDL-C reduction at IDOL, which mediates posttranscriptional regulation of the LDL receptor in response to intracellular cholesterol levels...
  4. Santos P, Oliveira T, Lemos P, Mill J, Krieger J, Pereira A. MYLIP p.N342S polymorphism is not associated with lipid profile in the Brazilian population. Lipids Health Dis. 2012;11:83 pubmed publisher
    A recent study investigated the MYLIP region in the Mexican population in order to fine-map the actual susceptibility variants of this locus. The p...
  5. Kararigas G, Bito V, Tinel H, Becher E, Baczkó I, Knosalla C, et al. Transcriptome characterization of estrogen-treated human myocardium identifies myosin regulatory light chain interacting protein as a sex-specific element influencing contractile function. J Am Coll Cardiol. 2012;59:410-7 pubmed publisher
    ..Of these, after E2 exposure, the myosin regulatory light chain interacting protein (MYLIP) gene was induced in tissues of men only...
  6. Do H, Tselykh T, Mäkelä J, Ho T, Olkkonen V, Bornhauser B, et al. Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap). J Biol Chem. 2012;287:12602-11 pubmed publisher
    ..The E3 ubiquitin ligase, myosin regulatory light chain-interacting protein (Mylip)/inducible degrader of the LDL-R (Idol) was shown to induce degradation of LDLR via protein ubiquitination...
  7. Yin R, Wu D, Aung L, Yan T, Cao X, Long X, et al. Several lipid-related gene polymorphisms interact with overweight/obesity to modulate blood pressure levels. Int J Mol Sci. 2012;13:12062-81 pubmed publisher
    ..reductase (MTHFR) 677C > T, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP) rs3757354, proprotein convertase subtilisin-like kexin type 9 (PCSK9) E670G, peroxisome proliferator-activated ..
  8. Zelcer N, Hong C, Boyadjian R, Tontonoz P. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science. 2009;325:100-4 pubmed publisher
    ..LXR inhibits the LDL receptor (LDLR) pathway through transcriptional induction of Idol (inducible degrader of the LDLR), an E3 ubiquitin ligase that triggers ubiquitination of the LDLR on its ..
  9. Dong B, Wu M, Cao A, Li H, Liu J. Suppression of Idol expression is an additional mechanism underlying statin-induced up-regulation of hepatic LDL receptor expression. Int J Mol Med. 2011;27:103-10 pubmed publisher
    Recent studies have identified proprotein convertase subtilisin/kexin type 9 (PCSK9) and Idol as negative regulators of low density lipoprotein receptor (LDLR) protein stability...

More Information

Publications133 found, 100 shown here

  1. Sorrentino V, Scheer L, Santos A, Reits E, Bleijlevens B, Zelcer N. Distinct functional domains contribute to degradation of the low density lipoprotein receptor (LDLR) by the E3 ubiquitin ligase inducible Degrader of the LDLR (IDOL). J Biol Chem. 2011;286:30190-9 pubmed publisher
    We recently identified the liver X receptor-regulated E3 ubiquitin ligase inducible degrader of the LDL receptor (IDOL) as a modulator of lipoprotein metabolism...
  2. Weissglas Volkov D, Calkin A, Tusie Luna T, Sinsheimer J, Zelcer N, Riba L, et al. The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans. J Clin Invest. 2011;121:3062-71 pubmed publisher
    ..The E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP; also known as IDOL) is a recently identified regulator of the LDL receptor (LDLR) pathway...
  3. Yan T, Yin R, Li Q, Huang P, Zeng X, Huang K, et al. Association of MYLIP rs3757354 SNP and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis. 2012;11:141 pubmed publisher
    ..single nucleotide polymorphism (SNP) in the E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP, also known as IDOL) gene and serum lipid levels is not well known in the general population...
  4. Sorrentino V, Fouchier S, Motazacker M, Nelson J, Defesche J, Dallinga Thie G, et al. Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein. Eur Heart J. 2013;34:1292-7 pubmed publisher
    Recent genome-wide association studies suggest that IDOL (also known as MYLIP) contributes to variation in circulating levels of low-density lipoprotein cholesterol (LDL-C)...
  5. Tutar Y. miRNA and cancer; computational and experimental approaches. Curr Pharm Biotechnol. 2014;15:429 pubmed
    ..Dr. Vasconcelos showed that overexpression of miR-128 decreased acute myeloid leukemia cells and increased the DNA damage...
  6. Kiang J, Smith J, Anderson M, Elliott T, Gupta P, Balakathiresan N, et al. Hemorrhage enhances cytokine, complement component 3, and caspase-3, and regulates microRNAs associated with intestinal damage after whole-body gamma-irradiation in combined injury. PLoS ONE. 2017;12:e0184393 pubmed publisher
    ..Among the altered miRNAs, CI increased miR-34 in the serum and ileum which targeted an increased phosphorylation of ERK, p38, and increased NF-?B, thereby ..
  7. Lim E, Lim J, Kim E, Kim Y, Shin J, Seok P, et al. Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice. Nutrients. 2016;8: pubmed
    ..The expression levels of miR-122a and miR-33a were higher and lower in the XB group, respectively...
  8. Erice O, Munoz Garrido P, Vaquero J, Perugorria M, Fernández Barrena M, Saez E, et al. MicroRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation. Hepatology. 2018;67:1420-1440 pubmed publisher
    ..MicroRNA (miR) dysregulation occurs in liver and immune cells of PBC patients, but its functional relevance is largely unknown...
  9. Mazzio E, Soliman K. HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells. Cancer Genomics Proteomics. 2017;14:17-33 pubmed
    ..g. hsa-miR-23b-5p, hsa-miR-27b-5p, hsa-miR-1180-3p, hsa-miR-6880-5p and hsa-mir-943)...
  10. Zou H, Wang Y, Gang Q, Zhang Y, Sun Y. Plasma level of miR-93 is associated with higher risk to develop type 2 diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol. 2017;255:1159-1166 pubmed publisher
    MicroRNA-93 (miR-93) usually acts as a promoter of tumor progression in several human carcinomas. It has been found distinctly high in eyes with proliferative diabetic retinopathy (DR)...
  11. Bhatia H, Pattnaik B, Datta M. Inhibition of mitochondrial β-oxidation by miR-107 promotes hepatic lipid accumulation and impairs glucose tolerance in vivo. Int J Obes (Lond). 2016;40:861-9 pubmed publisher
    ..In our previous study, we had demonstrated that fatty acid synthase (FASN) is a target of miR-107...
  12. Huang Y, Yang Y, Huang F, Tiao M, Lin Y, Tsai M, et al. MicroRNA-29a mitigation of endoplasmic reticulum and autophagy aberrance counteracts in obstructive jaundice-induced fibrosis in mice. Exp Biol Med (Maywood). 2017;:1535370217741500 pubmed publisher
    ..We have previously shown that microRNA-29a (miR-29a) protects against liver fibrosis...
  13. Bhattacharjya S, Roy K, Ganguly A, Sarkar S, Panda C, Bhattacharyya D, et al. Inhibition of nucleoporin member Nup214 expression by miR-133b perturbs mitotic timing and leads to cell death. Mol Cancer. 2015;14:42 pubmed publisher
    ..Databases/bioinformatic tools such as miRBase, Oncomine and RNAhybrid predicted Nup214 as a miR-133b target. To validate this, we used luciferase reporter assays, Real-Time PCR and immuno-blotting...
  14. Zheng Y, Jiang S, Zhang Y, Zhang R, Gong D. Detection of miR-33 Expression and the Verification of Its Target Genes in the Fatty Liver of Geese. Int J Mol Sci. 2015;16:12737-52 pubmed publisher
    ..The examination of miR-33 expression and its target genes can promote the in-depth study of the miRNA regulation mechanism in the ..
  15. Chen H, Zhao J, Li Y, He L, Huang Y, Shu W, et al. Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells. Toxicol Lett. 2018;289:42-53 pubmed publisher
    ..MiRNA-mRNA network and mRNA-mRNA network analysis showed that hsa-miR-320a, hsa-miR-331-3p, hsa-miR-26a-5p, hsa-miR-196a-5p, hsa-miR-221-3p, coiled-coil domain containing 180 (CCDC180), ..
  16. Smith J, Jeng S, McWeeney S, Hirsch A. A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection. J Virol. 2017;91: pubmed publisher
    ..Several families of miRNAs were identified as inhibiting multiple flaviviruses, including the miRNA miR-34, miR-15, and miR-517 families...
  17. Jia K, Pan S, Ding H, Liu J, Zheng Y, Wang S, et al. Chaihu-shugan san inhibits inflammatory response to improve insulin signaling in liver and prefrontal cortex of CUMS rats with glucose intolerance. Biomed Pharmacother. 2018;103:1415-1428 pubmed publisher
    ..RT-qPCR and Western blot analysis, as well as microRNA-155 (miR-155) mimic or inhibitor transfection were used to explore possible association of MyD88 and miR-155...
  18. Liu M, Liu R, Wu H, Li Y, Su M, Dong M, et al. Radix puerariae extracts ameliorate paraquat-induced pulmonary fibrosis by attenuating follistatin-like 1 and nuclear factor erythroid 2p45-related factor-2 signalling pathways through downregulation of miRNA-21 expression. BMC Complement Altern Med. 2016;16:11 pubmed publisher
    ..We examined effects of miR-21 on follistatin-like 1 (Fstl 1) pathways and oxidative stress in the lung...
  19. Kodo K, Sugimoto S, Nakajima H, Mori J, Itoh I, Fukuhara S, et al. Erythropoietin (EPO) ameliorates obesity and glucose homeostasis by promoting thermogenesis and endocrine function of classical brown adipose tissue (BAT) in diet-induced obese mice. PLoS ONE. 2017;12:e0173661 pubmed publisher
    ..EPO's suppression of myocyte enhancer factor 2c (Mef2c) and microRNA-133a (miR-133a) via ?3-adrenergic receptor caused PRDM16 upregulation...
  20. Janaki Ramaiah M, Lavanya A, Honarpisheh M, Zarea M, Bhadra U, Bhadra M. MiR-15/16 complex targets p70S6 kinase 1 and controls cell proliferation in MDA-MB-231 breast cancer cells. Gene. 2014;552:255-64 pubmed publisher
    ..To have a better insight of the role of miR-15/16 in regulating the cross talk of p53 and mTOR, we performed an in depth study in MDA-MB-231 breast cancer ..
  21. Satishchandran A, Ambade A, Rao S, Hsueh Y, Iracheta Vellve A, Tornai D, et al. MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease. Gastroenterology. 2018;154:238-252.e7 pubmed publisher
    ..and controls, were given injections of recombinant adeno-associated virus 8 vector that expressed the primary miR-122 transcript (pri-MIR122, to overexpress MIR122 in hepatocytes) or vector (control)...
  22. Henshall D, Hamer H, Pasterkamp R, Goldstein D, Kjems J, Prehn J, et al. MicroRNAs in epilepsy: pathophysiology and clinical utility. Lancet Neurol. 2016;15:1368-1376 pubmed publisher
    ..Early functional studies showed that silencing of brain-specific miR-134 using antisense oligonucleotides (antagomirs) had potent antiseizure effects in animal models, whereas genetic ..
  23. Chen D, Dixon B, Doycheva D, Li B, Zhang Y, Hu Q, et al. IRE1? inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats. J Neuroinflammation. 2018;15:32 pubmed publisher
    ..In the present study, we sought to investigate whether microRNA-17 (miR-17), a potential IRE1? ribonuclease (RNase) substrate, arbitrates downregulation of thioredoxin-interacting protein ..
  24. Kuwano Y, Nishida K, Kajita K, Satake Y, Akaike Y, Fujita K, et al. Transformer 2β and miR-204 regulate apoptosis through competitive binding to 3' UTR of BCL2 mRNA. Cell Death Differ. 2015;22:815-25 pubmed publisher
    ..respectively, showed that Tra2β bound to BCL2α 3' UTR, and that Tra2β knockdown facilitated association of miR-204 with BCL2α 3' UTR...
  25. Piletič K, Kunej T. MicroRNA epigenetic signatures in human disease. Arch Toxicol. 2016;90:2405-19 pubmed publisher
    ..The review revealed that hsa-miR-34a, hsa-miR-34b, and hsa-miR-34c are the most frequently reported epigenetically dysregulated miRNAs...
  26. Liu D, Han L, Wu X, Yang X, Zhang Q, Jiang F. Genome-wide microRNA changes in human intracranial aneurysms. BMC Neurol. 2014;14:188 pubmed publisher
    ..The changed microRNAs included endothelium-enriched microRNAs such as members of the let-7 family, miR-17, miR-23b, miR-126, hsa-miR-24-1 and miR-222, and vascular smooth muscle-enriched miRNAs such as miR-143 and miR-..
  27. McLendon J, Joshi S, Sparks J, Matar M, Fewell J, Abe K, et al. Lipid nanoparticle delivery of a microRNA-145 inhibitor improves experimental pulmonary hypertension. J Control Release. 2015;210:67-75 pubmed publisher
    ..survival and cell fate that are associated with development of PAH, including increased expression of microRNA-145 (miR-145)...
  28. Chen Q, Wu F, Wang M, Dong S, Liu Y, Lu Y, et al. Transcriptional Profiling and miRNA-Target Network Analysis Identify Potential Biomarkers for Efficacy Evaluation of Fuzheng-Huayu Formula-Treated Hepatitis B Caused Liver Cirrhosis. Int J Mol Sci. 2016;17: pubmed publisher
    ..By means of a logistic regression model, a miRNA panel with hsa-miR-18a-5p, -326, -1182 and -193b-5p was established, and it can clearly improve the accuracy of the efficacy ..
  29. Gong C, Tan W, Chen K, You N, Zhu S, Liang G, et al. Prognostic Value of a BCSC-associated MicroRNA Signature in Hormone Receptor-Positive HER2-Negative Breast Cancer. EBioMedicine. 2016;11:199-209 pubmed publisher
    ..In this multicenter study, a 10-miRNA classifier incorporating miR-21, miR-30c, miR-181a, miR-181c, miR-125b, miR-7, miR-200a, miR-135b, miR-22 and miR-200c was developed to predict ..
  30. Pan X, Xiao X, Qin H, Zhang Z, Li Z, Gao L, et al. MicroRNA variants and colorectal cancer risk: a meta-analysis. Genet Mol Res. 2016;15: pubmed publisher
    ..No relationship was established between this disease and the three SNPs rs11614913, rs2910164, and rs3746444 in miR-196a-2, miR-146a, and miR-499, respectively...
  31. Yang H, Sun C, Liang J, Xu L, Zhang Z, Luo D, et al. Supercritical-Carbon Dioxide Fluid Extract from Chrysanthemum indicum Enhances Anti-Tumor Effect and Reduces Toxicity of Bleomycin in Tumor-Bearing Mice. Int J Mol Sci. 2017;18: pubmed publisher
    ..protein expression of p53 and down-regulated the transforming growth factor-?1 by activating the gene expression of miR-29b...
  32. Ji C, Liu H, Yin Q, Li H, Gao H. miR-93 enhances hepatocellular carcinoma invasion and metastasis by EMT via targeting PDCD4. Biotechnol Lett. 2017;39:1621-1629 pubmed publisher
    To clarify the potential biological function of miR-93 and its related molecular mechanism underlying metastasis in human hepatocellular carcinoma (HCC)...
  33. Akkaya Ulum Y, Balci Peynircioglu B, Karadag O, Eroglu F, Kalyoncu U, Kiraz S, et al. Alteration of the microRNA expression profile in familial Mediterranean fever patients. Clin Exp Rheumatol. 2017;35 Suppl 108:90-94 pubmed
    ..14 miRNAs were found to be significant among groups through the analysis with MeV. miR-20a-5p, miR-197-3p, let-7d-3p and miR-574-3p were found to be associated with inflammatory pathway related genes ..
  34. Diao H, Low W, Milbreta U, Lu Q, Chew S. Nanofiber-mediated microRNA delivery to enhance differentiation and maturation of oligodendroglial precursor cells. J Control Release. 2015;208:85-92 pubmed publisher
    ..Therefore, in this study, we developed a nanofiber-mediated microRNA (miR) delivery method to control oligodendroglial precursor cell (OPC) differentiation through a combination of fiber ..
  35. Sheng L, He P, Yang X, Zhou M, Feng Q. miR-612 negatively regulates colorectal cancer growth and metastasis by targeting AKT2. Cell Death Dis. 2015;6:e1808 pubmed publisher
    ..In this study, we found that miR-612 expression was significantly lower in CRC tissues or cells compared with peritumor tissues or normal cells, and ..
  36. Kontaraki J, Marketou M, Parthenakis F, Maragkoudakis S, Zacharis E, Petousis S, et al. Hypertrophic and antihypertrophic microRNA levels in peripheral blood mononuclear cells and their relationship to left ventricular hypertrophy in patients with essential hypertension. J Am Soc Hypertens. 2015;9:802-810 pubmed publisher
    ..We assessed the expression levels of the microRNAs miR-1, miR-133a, miR-26b, miR-208b, miR-499, and miR-21, in 102 patients with essential hypertension and 30 healthy ..
  37. Pan J, Yuan D, Nie L, Zhang J, Yue L. [Progesterone-induced microRNA-1a inhibits the proliferation of endometrial epithelial cells]. Sheng Li Xue Bao. 2016;68:716-724 pubmed
    The aim of the present study was to investigate the effects of progesterone (P4)-induced microRNA-1a (miR-1a) on the proliferation of endometrial epithelial cells (EECs) and the underlying mechanism...
  38. Wang C, Zhang X, Zhang C, Zhai F, Li Y, Huang Z. MicroRNA-155 targets MAP3K10 and regulates osteosarcoma cell growth. Pathol Res Pract. 2017;213:389-393 pubmed publisher
    ..In this study, we found miR-155 up-regulation in different osteosarcoma cell lines U2OS, Saos-2 and MG-63...
  39. Zhang J, Liu W, Peng J, Ma Q, Peng J, Luo X. miR-21-5p/203a-3p promote ox-LDL-induced endothelial cell senescence through down-regulation of mitochondrial fission protein Drp1. Mech Ageing Dev. 2017;164:8-19 pubmed publisher
    ..Among the 7 selected miRNAs, miR-21-5p and miR-203a-3p were significantly up-regulated in a human umbilical vein endothelial cells (HUVECs) ..
  40. Waller R, Goodall E, Milo M, Cooper Knock J, Da Costa M, Hobson E, et al. Serum miRNAs miR-206, 143-3p and 374b-5p as potential biomarkers for amyotrophic lateral sclerosis (ALS). Neurobiol Aging. 2017;55:123-131 pubmed publisher
    ..Validation in an additional patient cohort showed that miR-206 and miR-143-3p were increased and miR-374b-5p was decreased compared to controls...
  41. Yang Y, Qu A, Liu J, Wang R, Liu Y, Li G, et al. Serum miR-210 Contributes to Tumor Detection, Stage Prediction and Dynamic Surveillance in Patients with Bladder Cancer. PLoS ONE. 2015;10:e0135168 pubmed publisher
    b>MiR-210 is the master hypoxamir that generally exhibits oncogenic properties in most human solid tumors including bladder cancer (BC). However, it remains unknown about the clinical significance of circulating miR-210 levels in BC...
  42. Koutalianos D, Koutsoulidou A, Mastroyiannopoulos N, Furling D, Phylactou L. MyoD transcription factor induces myogenesis by inhibiting Twist-1 through miR-206. J Cell Sci. 2015;128:3631-45 pubmed publisher
    ..b>miR-206, one of the most important muscle-specific miRNAs (myomiRs), was identified as a possible regulator of Twist-1 ..
  43. Wu H, Huang C, Taki F, Zhang Y, Dobbins D, Li L, et al. Benzo-α-pyrene induced oxidative stress in Caenorhabditis elegans and the potential involvements of microRNA. Chemosphere. 2015;139:496-503 pubmed publisher
    ..Out of the 28 tested microRNAs, expressions of miR-1, miR-355, miR-50, miR-51, miR-58, miR-796, miR-797, and miR-84 were modified...
  44. Yao S, Hu M, Hao T, Li W, Xue X, Xue M, et al. MiRNA-891a-5p mediates HIV-1 Tat and KSHV Orf-K1 synergistic induction of angiogenesis by activating NF-κB signaling. Nucleic Acids Res. 2015;43:9362-78 pubmed publisher
    ..Mechanistically, we showed that Tat synergized with K1 to induce the expression of miR-891a-5p, which directly targeted IκBα 3' untranslated region, leading to NF-κB activation...
  45. Fragni M, Bonini S, Bettinsoli P, Bodei S, Generali D, Bottini A, et al. The miR-21/PTEN/Akt signaling pathway is involved in the anti-tumoral effects of zoledronic acid in human breast cancer cell lines. Naunyn Schmiedebergs Arch Pharmacol. 2016;389:529-38 pubmed publisher
    ..anti-cancer effects of ZA in human breast cancer cell lines, suggesting that they may in part be mediated via the miR-21/PTEN/Akt signaling pathway...
  46. Yoon J, Choi W, Kim O, Choi B, Nam S, Lee J, et al. Gastrokine 1 inhibits gastric cancer cell migration and invasion by downregulating RhoA expression. Gastric Cancer. 2017;20:274-285 pubmed publisher
    ..We analyzed the expression of GKN1, RhoA, miR-185, and miR-34a in 35 gastric cancer tissues, and compared their expression with T category and TNM stage...
  47. Samuels T, Yan J, Khampang P, Mackinnon A, Hong W, Johnston N, et al. Association of microRNA 146 with middle ear hyperplasia in pediatric otitis media. Int J Pediatr Otorhinolaryngol. 2016;88:104-8 pubmed publisher
    ..Recent studies implicate microRNA 146 (miR-146) in regulation of inflammation via negative feedback of toll-like receptor signaling (TLR) in a wide variety of ..
  48. Zhu Z, Huang P, Chong Y, Kang L, Huang X, Zhu Z, et al. MicroRNA-181a promotes proliferation and inhibits apoptosis by suppressing CFIm25 in osteosarcoma. Mol Med Rep. 2016;14:4271-4278 pubmed publisher
    MicroRNA-181a (miR-181a) is upregulated in osteosarcoma, and its overexpression promotes the proliferation and inhibits the apoptosis of osteosarcoma cells...
  49. Mercatelli N, Fittipaldi S, De Paola E, Dimauro I, Paronetto M, Jackson M, et al. MiR-23-TrxR1 as a novel molecular axis in skeletal muscle differentiation. Sci Rep. 2017;7:7219 pubmed publisher
    ..Moreover, we found that miR-23a and miR-23b - whose expression was increased in the early stage of C2C12 differentiation - are involved in the ..
  50. Ahmadinejad F, Mowla S, Honardoost M, Arjenaki M, Moazeni Bistgani M, Kheiri S, et al. Lower expression of miR-218 in human breast cancer is associated with lymph node metastases, higher grades, and poorer prognosis. Tumour Biol. 2017;39:1010428317698362 pubmed publisher
    ..Accumulating studies suggest that miR-218 plays a multifunctional role in various cancer types and different stages...
  51. Gao S, Liu H, Hou S, Wu L, Yang Z, Shen J, et al. MiR-489 suppresses tumor growth and invasion by targeting HDAC7 in colorectal cancer. Clin Transl Oncol. 2018;20:703-712 pubmed publisher
    The expression of miR-489 is linked to tumor development and progression; nevertheless, its role in tumor growth and invasion of colorectal cancer (CRC) and the underlying mechanism has not been clarified...
  52. Wang J, Zhang Q, Wang D, Yan W, Sha H, Zhao J, et al. MiR-29a: a potential therapeutic target and promising biomarker in tumors. Biosci Rep. 2018;38: pubmed publisher
    ..Amongst which, miR-29a was demonstrated that it had significant impact on oncogenicity in various neoplasms through binding to ..
  53. Fu F, Wu D, Qian C. The MicroRNA-224 Inhibitor Prevents Neuronal Apoptosis via Targeting Spastic Paraplegia 7 After Cerebral Ischemia. J Mol Neurosci. 2016;59:421-9 pubmed publisher
    Recently, the study of microRNA expression profile has shown that miR-224 was implicated in neuron injury, but the mechanism of miR-224 on regulating neuronal apoptosis is completely unclear until now...
  54. Li S, Wang C, Yu X, Wu H, Hu J, Wang S, et al. miR-3619-5p inhibits prostate cancer cell growth by activating CDKN1A expression. Oncol Rep. 2017;37:241-248 pubmed publisher
    ..In the present study, we identified a new endogenous miR-3619-5p which was decreased in prostate cancer tissues and cells compared to corresponding normal controls...
  55. Gan T, Chen W, Qin H, Huang S, Yang L, Fang Y, et al. Clinical Value and Prospective Pathway Signaling of MicroRNA-375 in Lung Adenocarcinoma: A Study Based on the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and Bioinformatics Analysis. Med Sci Monit. 2017;23:2453-2464 pubmed
    ..MATERIAL AND METHODS We evaluated the significance of miR-375 expression in LUAD by using analysis of a public dataset from the Cancer Genome Atlas (TCGA) and Gene ..
  56. Tian C, Li J, Ren L, Peng R, Chen B, Lin Y. MicroRNA-381 serves as a prognostic factor and inhibits migration and invasion in non-small cell lung cancer by targeting LRH-1. Oncol Rep. 2017;38:3071-3077 pubmed publisher
    ..Dysregulation of miR-381 has been reported in different tumors...
  57. Deng X, Qin S, Chen Y, Liu H, Yuan E, Deng H, et al. B-RCA revealed circulating miR-33a/b associates with serum cholesterol in type 2 diabetes patients at high risk of ASCVD. Diabetes Res Clin Pract. 2018;140:191-199 pubmed publisher
    ..Dyslipidemia is the leading cause of atherosclerotic cardiovascular diseases (ASCVD) in T2D patients. hsa-miR-33 (miR-33) serves as a regulator in lipid metabolism...
  58. Wang L, Zhang K, Zhang N, Ma X, Yan S, Cao D, et al. Serum miR-26a as a diagnostic and prognostic biomarker in cholangiocarcinoma. Oncotarget. 2015;6:18631-40 pubmed
    In order to determine the diagnostic and prognostic value of miR-26a in Cholangiocarcinoma (CCA), we compared miR-26a levels in serum from 66 CCA patients and 66 healthy controls, which was followed by serum analysis between the pre-..
  59. Riesco Eizaguirre G, Wert Lamas L, Perales Patón J, Sastre Perona A, Fernández L, Santisteban P. The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells during Carcinogenesis. Cancer Res. 2015;75:4119-30 pubmed publisher
    ..Both mature products of mir-146b (miR-146b-5p and -3p) were among the most abundantly expressed miRNAs in tumors...
  60. Yang R, Yi L, Dong Z, Ouyang Q, Zhou J, Pang Y, et al. Tigecycline Inhibits Glioma Growth by Regulating miRNA-199b-5p-HES1-AKT Pathway. Mol Cancer Ther. 2016;15:421-9 pubmed publisher
    ..We found that miR-199b-5p expression was significantly increased after tigecycline treatment, and miR-199b-5p target gene HES1 was ..
  61. Zhou X, Liang Y, Xu Y, Lin X, Chen J, Ma Y, et al. Triple cascade reactions: An ultrasensitive and specific single tube strategy enabling isothermal analysis of microRNA at sub-attomole level. Biosens Bioelectron. 2016;80:378-384 pubmed publisher
    ..As a result, the miR-27a target model was rapidly determined with a limit of detection down to 0...
  62. Luo P, Zhang W, Qian Z, Xiao L, Wang H, Zhu T, et al. MiR-590-5p-meidated LOX-1 upregulation promotes Angiotensin II-induced endothelial cell apoptosis. Biochem Biophys Res Commun. 2016;471:402-8 pubmed publisher
    ..This study aims to investigate the role of miR-590-5p in endothelial cell apoptosis and dissect the underlying mechanisms...
  63. Safari A, Azizmohammadi S, Kaghazian M, Sadrkhanlo M, Yahaghi E, Farshgar R, et al. Molecular identification of miR-145 and miR-9 expression level as prognostic biomarkers for early-stage cervical cancer detection. QJM. 2017;110:11-15 pubmed publisher
    ..To evaluate the clinical importance and prognostic value of miR-9 and miR-145 in cervical cancer...
  64. Harrandah A, Fitzpatrick S, Smith M, Wang D, Cohen D, Chan E. MicroRNA-375 as a biomarker for malignant transformation in oral lesions. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122:743-752.e1 pubmed publisher
    ..Previously, we identified miR-7 and miR-21 as candidate oncogenes and miR-375 and miR-494 as candidate tumor suppressors in OSCC...
  65. Liu M, Gao M, Li C, Yu C, Yan H, Peng C, et al. Dicer1/miR-29/HMGCR axis contributes to hepatic free cholesterol accumulation in mouse non-alcoholic steatohepatitis. Acta Pharmacol Sin. 2017;38:660-671 pubmed publisher
    ..Eleven predicted miRNAs were screened, revealing that miR-29a/b/c significantly suppressed HMGCR expression by targeting the HMGCR mRNA 3'-UTR...
  66. Eding J, Demkes C, Lynch J, Seto A, Montgomery R, Semus H, et al. The Efficacy of Cardiac Anti-miR-208a Therapy Is Stress Dependent. Mol Ther. 2017;25:694-704 pubmed publisher
    ..However, whether disease conditions (stress) influence the pharmacological effects of an anti-miR is currently unknown...
  67. Qu B, Gong K, Yang H, Li Y, Jiang T, Zeng Z, et al. MiR-449 overexpression inhibits osteogenic differentiation of bone marrow mesenchymal stem cells via suppressing Sirt1/Fra-1 pathway in high glucose and free fatty acids microenvironment. Biochem Biophys Res Commun. 2018;496:120-126 pubmed publisher
    ..In this study, we investigate the effect of miR-449 on osteogenic differentiation and its underlying mechanism in human bone marrow-derived mesenchymal stem cells (..
  68. Lv H, Sun Y, Zhang Y. MiR-133 is Involved in Estrogen Deficiency-Induced Osteoporosis through Modulating Osteogenic Differentiation of Mesenchymal Stem Cells. Med Sci Monit. 2015;21:1527-34 pubmed publisher
    b>MiR-133 expression is dysregulated in postmenopausal osteoporosis. However, its role in postmenopausal osteoporosis is still not well understood...
  69. Iseki Y, Shibutani M, Maeda K, Nagahara H, Fukuoka T, Ikeya T, et al. Prognostic Significance of MicroRNA-21 Expression in Patients with Unresectable Metastatic Colon Cancer. Anticancer Res. 2016;36:5145-5151 pubmed
    MicroRNA (miR)-21 is overexpressed in most solid tumors and a high expression of miR-21 in tumor tissue is associated with a poor clinical outcome...
  70. Nawaz Z, Patil V, Paul Y, Hegde A, Arivazhagan A, Santosh V, et al. PI3 kinase pathway regulated miRNome in glioblastoma: identification of miR-326 as a tumour suppressor miRNA. Mol Cancer. 2016;15:74 pubmed
    ..qRT-PCR was used to measure the abundance of miR-326 and its host gene encoded transcript...
  71. van Kampen J, van Hooij O, Jansen C, Smit F, van Noort P, Schultz I, et al. miRNA-520f Reverses Epithelial-to-Mesenchymal Transition by Targeting ADAM9 and TGFBR2. Cancer Res. 2017;77:2008-2017 pubmed publisher
    ..By this approach, we defined miR-520f as a novel EMT-reversing miRNA...
  72. Wang C, Zhou B, Liu M, Liu Y, Gao R. miR-126-5p Restoration Promotes Cell Apoptosis in Cervical Cancer by Targeting Bcl2l2. Oncol Res. 2017;25:463-470 pubmed publisher
    ..In the present study, we investigated the role of miR-126-5p and Bcl2l2 in cervical cancer cells...
  73. Sugito N, Taniguchi K, Kuranaga Y, Ohishi M, Soga T, Ito Y, et al. Cancer-Specific Energy Metabolism in Rhabdomyosarcoma Cells Is Regulated by MicroRNA. Nucleic Acid Ther. 2017;: pubmed publisher
    ..We investigated the expression and effects of muscle-specific miR-1 and miR-133b on RMS cells (RD, KYM-1, Rh30, and Rh41) from the view of energy metabolism and regulation of the ..
  74. Wu Y, Wang H. LncRNA NEAT1 promotes dexamethasone resistance in multiple myeloma by targeting miR-193a/MCL1 pathway. J Biochem Mol Toxicol. 2017;: pubmed publisher
    ..The in-depth study revealed that during the development of DEX resistance in these cells, the miR-193a levels were decreased, which resulted in the increased expression of the target gene myeloid cell leukemia-1 (..
  75. Wang Z, Pan L, Yu H, Wang Y. The long non-coding RNA SNHG5 regulates gefitinib resistance in lung adenocarcinoma cells by targetting miR-377/CASP1 axis. Biosci Rep. 2018;38: pubmed publisher
    ..Bioinformatics analysis showed that SNHG5 exerted its function through interaction with miR-377, which was further confirmed by luciferase reporter assay in 293T cells...
  76. Chen C, Wang D, Moshaverinia A, Liu D, Kou X, Yu W, et al. Mesenchymal stem cell transplantation in tight-skin mice identifies miR-151-5p as a therapeutic target for systemic sclerosis. Cell Res. 2017;27:559-577 pubmed publisher
    ..Mechanistically, we show that donor MSCs transfer miR-151-5p to the recipient bone marrow MSCs in SSc mice to inhibit IL4R? expression, thus downregulating mTOR pathway ..
  77. Gu S, Sun D, Li X, Zhang Z. Alterations of miRNAs and Their Potential Roles in Arsenite-Induced Transformation of Human Bronchial Epithelial Cells. Genes (Basel). 2017;8: pubmed publisher
    ..regulatory network, which was constructed by cytoscape software with miRNAs and their target genes, showed that miR-15b-5p, miR-106b-5p, and miR-320d were the core hubs...
  78. Bache S, Rasmussen R, Rossing M, Laigaard F, Nielsen F, Møller K. MicroRNA Changes in Cerebrospinal Fluid After Subarachnoid Hemorrhage. Stroke. 2017;48:2391-2398 pubmed publisher
    ..001); 2 (miR-21 and miR-221) showed a relative increase in SAH patients with DCI compared with those without (P<0...
  79. Xu A, Fu L, Wu H, Yao X, Meng R. MicroRNA?744 inhibits tumor cell proliferation and invasion of gastric cancer via targeting brain?derived neurotrophic factor. Mol Med Rep. 2017;16:5055-5061 pubmed publisher
    ..Therefore, miRNAs have been proposed as promising therapeutic targets in gastric cancer patients. MiR?744 is aberrantly expressed in different types of human cancer...
  80. Shen S, Huang K, Wu Y, Ma Y, Wang J, Qin F, et al. A miR-135b-TAZ positive feedback loop promotes epithelial-mesenchymal transition (EMT) and tumorigenesis in osteosarcoma. Cancer Lett. 2017;407:32-44 pubmed publisher
    ..The miRNA miR-135b, which is directly induced by TAZ, suppressed the TAZ inhibitors large tumor suppressor 2, adenomatous ..
  81. Okato A, Arai T, Yamada Y, Sugawara S, Koshizuka K, Fujimura L, et al. Dual Strands of Pre-miR-149 Inhibit Cancer Cell Migration and Invasion through Targeting FOXM1 in Renal Cell Carcinoma. Int J Mol Sci. 2017;18: pubmed publisher
    Our recent studies revealed that dual strands of certain pre-microRNAs, e.g., pre-miR-144, pre-miR-145, and pre-miR-150, act as antitumor microRNAs (miRNAs) in several cancers...
  82. Han C, Seebacher N, Hornicek F, Kan Q, Duan Z. Regulation of microRNAs function by circular RNAs in human cancer. Oncotarget. 2017;8:64622-64637 pubmed publisher
    ..Interestingly, it has recently been confirmed that circRNAs bind to microRNAs (miRs), as miR "sponges", acting to suppress miR function...
  83. Fawzy M, Toraih E, Ibrahiem A, Abdeldayem H, Mohamed A, Abdel Daim M. Evaluation of miRNA-196a2 and apoptosis-related target genes: ANXA1, DFFA and PDCD4 expression in gastrointestinal cancer patients: A pilot study. PLoS ONE. 2017;12:e0187310 pubmed publisher
    ..The current preliminary study aimed to evaluate the relative expression levels of miR-196a2 and three of its selected apoptosis-related targets; ANXA1, DFFA and PDCD4 in a sample of GI cancer patients...
  84. Gu W, Yuan Y, Yang H, Wu H, Wang L, Tang Z, et al. Role of miR-195 in cigarette smoke-induced chronic obstructive pulmonary disease. Int Immunopharmacol. 2018;55:49-54 pubmed publisher
    ..Recent data have suggested that some miRNAs are involved in the pathogenesis of COPD. Here, we found that miR-195 was significantly upregulated in the lung tissues of patients with COPD compared to in never smokers...
  85. Layne C, Mulavara A, McDonald P, Pruett C, Kozlovskaya I, Bloomberg J. Effect of long-duration spaceflight on postural control during self-generated perturbations. J Appl Physiol (1985). 2001;90:997-1006 pubmed
    ..associated with arm movement of eight subjects who experienced long-duration spaceflight (3--6 mo) aboard the Mir space station...
  86. Liu W, Zhao J, Lu G. miR-106b inhibits tau phosphorylation at Tyr18 by targeting Fyn in a model of Alzheimer's disease. Biochem Biophys Res Commun. 2016;478:852-7 pubmed publisher
    ..In this study, we investigated the role of miR-106b in tau phosphorylation and identified a new molecular mechanism of the hyperphosphorylation of tau...
  87. Yuan M, Zhang L, You F, Zhou J, Ma Y, Yang F, et al. MiR-145-5p regulates hypoxia-induced inflammatory response and apoptosis in cardiomyocytes by targeting CD40. Mol Cell Biochem. 2017;431:123-131 pubmed publisher
    ..In this study, we sought to investigate the specific role and the underlying regulatory mechanism of miR-145-5p in myocardial ischemic injury...
  88. Li C, Zhu Y, Li Q, Li D, Yang G. [Relationship between Helicobacter pylori infection and miR-24-3p expression during the development of gastric mucosa lesions]. Zhonghua Yi Xue Za Zhi. 2017;97:2852-2855 pubmed publisher
    b>Objectives: To explore the expression of micro RNA-24-3p (miR-24-3p) in different gastric mucosa lesions, and analyze the potential correlation between Helicobacter pylori (H...
  89. Yang Q, Zhang X, Shi Y, He Y, Sun Z, Shi H, et al. Increased Expression of NDRG3 in Mouse Uterus During Embryo Implantation and in Mouse Endometrial Stromal Cells During In Vitro Decidualization. Reprod Sci. 2018;25:1197-1207 pubmed publisher
    ..b>miR-290b-5p was identified as an upstream regulator of Ndrg3, and the uterine expression level of miR-290b-5p was ..
  90. Zhao Z, Luo J, Li H, Wang S, Li X. SOX2-mediated inhibition of miR-223 contributes to STIM1 activation in phenylephrine-induced hypertrophic cardiomyocytes. Mol Cell Biochem. 2018;443:47-56 pubmed publisher
    ..a model of hypertrophic neonatal rat cardiomyocytes (HNRCs) in vitro, and low expression of primary and mature miR-223 was detected in PE-induced HNRCs...
  91. Rodil Garcia P, Arellanes Licea E, Montoya Contreras A, Salazar Olivo L. Analysis of MicroRNA Expression in Newborns with Differential Birth Weight Using Newborn Screening Cards. Int J Mol Sci. 2017;18: pubmed publisher
    ..The optimized extraction of RNA resulted in a 1.2-fold enrichment of miRNAs respect to the commercial kit. miR-33b and miR-375 were overexpressed in macrosomia 9.8-fold (p < 0.001) and 1.7-fold, (p < 0...
  92. Chen M, Lin M, Wang X. Overexpression of miR-19a inhibits colorectal cancer angiogenesis by suppressing KRAS expression. Oncol Rep. 2018;39:619-626 pubmed publisher
    The microRNA miR-19a is closely related to tumor formation and development and is a key oncogene. Previous studies have demonstrated that miR-19a is upregulated in multiple cancer types, including colorectal cancer (CRC)...