MYH9

Summary

Gene Symbol: MYH9
Description: myosin, heavy chain 9, non-muscle
Alias: BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHC-IIA, NMMHCA, cellular myosin heavy chain, type A, myosin heavy chain 9, myosin heavy chain, non-muscle IIa, myosin-9, non-muscle myosin heavy chain A, non-muscle myosin heavy chain IIa, non-muscle myosin heavy polypeptide 9, nonmuscle myosin heavy chain II-A
Species: human

Top Publications

  1. ncbi Mts1 regulates the assembly of nonmuscle myosin-IIA
    Zhong hua Li
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 42:14258-66. 2003
  2. pmc Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene
    Shay Tzur
    Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Hum Genet 128:345-50. 2010
  3. doi Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1
    Jun Arii
    Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Nature 467:859-62. 2010
  4. pmc MYH9 is associated with nondiabetic end-stage renal disease in African Americans
    W H Linda Kao
    Department of Epidemiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Nat Genet 40:1185-92. 2008
  5. pmc African ancestry allelic variation at the MYH9 gene contributes to increased susceptibility to non-diabetic end-stage kidney disease in Hispanic Americans
    Doron M Behar
    Molecular Medicine Laboratory, Rambam Health Care Campus, Haifa 31096, Israel
    Hum Mol Genet 19:1816-27. 2010
  6. ncbi Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related disease
    Alessandro Pecci
    Department of Internal Medicine, University of Pavia and Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Policlinico San Matteo Foundation, Pavia, Italy
    Hum Mutat 29:409-17. 2008
  7. pmc Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans
    Jessica N Cooke
    Program in Molecular Medicine and Translational Science, Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 27:1505-11. 2012
  8. ncbi MYH9-related disease: May-Hegglin anomaly, Sebastian syndrome, Fechtner syndrome, and Epstein syndrome are not distinct entities but represent a variable expression of a single illness
    Marco Seri
    Laboratorio di Genetica Molecolare, Istituto G Gaslini, Genova, Italy
    Medicine (Baltimore) 82:203-15. 2003
  9. pmc Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15
    George W Nelson
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    Hum Mol Genet 19:1805-15. 2010
  10. pmc Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration
    Nicole A Morin
    Department of Surgery, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
    J Exp Med 205:195-205. 2008

Research Grants

Detail Information

Publications193 found, 100 shown here

  1. ncbi Mts1 regulates the assembly of nonmuscle myosin-IIA
    Zhong hua Li
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 42:14258-66. 2003
    ..Altogether, these observations are consistent with mts1 regulating myosin IIA assembly by monomer sequestration and suggest that mts1 regulates cell shape and motility through the modulation of myosin-IIA function...
  2. pmc Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene
    Shay Tzur
    Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Hum Genet 128:345-50. 2010
    b>MYH9 has been proposed as a major genetic risk locus for a spectrum of nondiabetic end stage kidney disease (ESKD)...
  3. doi Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1
    Jun Arii
    Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Nature 467:859-62. 2010
    ..The identification of NMHC-IIA as an HSV-1 entry receptor and the involvement of NM-IIA regulation in HSV-1 infection provide an insight into HSV-1 entry and identify new targets for antiviral drug development...
  4. pmc MYH9 is associated with nondiabetic end-stage renal disease in African Americans
    W H Linda Kao
    Department of Epidemiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Nat Genet 40:1185-92. 2008
    ..2 to 0.6) in the gene encoding nonmuscle myosin heavy chain type II isoform A (MYH9) were associated with two to four times greater risk of nondiabetic ESRD and accounted for a large proportion of ..
  5. pmc African ancestry allelic variation at the MYH9 gene contributes to increased susceptibility to non-diabetic end-stage kidney disease in Hispanic Americans
    Doron M Behar
    Molecular Medicine Laboratory, Rambam Health Care Campus, Haifa 31096, Israel
    Hum Mol Genet 19:1816-27. 2010
    Recent studies identified MYH9 as a major susceptibility gene for common forms of non-diabetic end-stage kidney disease (ESKD)...
  6. ncbi Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related disease
    Alessandro Pecci
    Department of Internal Medicine, University of Pavia and Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Policlinico San Matteo Foundation, Pavia, Italy
    Hum Mutat 29:409-17. 2008
    b>MYH9-related disease (MYH9-RD) is a rare autosomal-dominant disorder caused by mutations in MYH9, the gene for the heavy chain of nonmuscle myosin IIA (NMMHC-IIA)...
  7. pmc Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans
    Jessica N Cooke
    Program in Molecular Medicine and Translational Science, Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 27:1505-11. 2012
    Polymorphisms in the non-muscle myosin IIA gene (MYH9) are associated with focal segmental glomerulosclerosis (FSGS) and non-diabetic end-stage renal disease (ESRD) in African Americans and FSGS in European Americans...
  8. ncbi MYH9-related disease: May-Hegglin anomaly, Sebastian syndrome, Fechtner syndrome, and Epstein syndrome are not distinct entities but represent a variable expression of a single illness
    Marco Seri
    Laboratorio di Genetica Molecolare, Istituto G Gaslini, Genova, Italy
    Medicine (Baltimore) 82:203-15. 2003
    ..Mutations in the MYH9 gene encoding for the nonmuscle myosin heavy chain IIA (NMMHC-IIA) have been identified in all these syndromes...
  9. pmc Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15
    George W Nelson
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    Hum Mol Genet 19:1805-15. 2010
    Admixture mapping recently identified MYH9 as a susceptibility gene for idiopathic focal segmental glomerulosclerosis (FSGS), HIV-associated nephropathy (HIVAN) and end-stage kidney disease attributed to hypertension (H-ESKD) in African ..
  10. pmc Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration
    Nicole A Morin
    Department of Surgery, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
    J Exp Med 205:195-205. 2008
    ..Here, we show that nonmuscle myosin heavy chain IIA (MyH9) is recruited to LFA-1 at the uropod of migrating T lymphocytes, and inhibition of the association of MyH9 with LFA-..
  11. ncbi Expression of the nonmuscle myosin heavy chain IIA in the human kidney and screening for MYH9 mutations in Epstein and Fechtner syndromes
    Christelle Arrondel
    INSERM U 423, Universite Rene Descartes, Hopital Necker Enfants Malades, Paris, France
    J Am Soc Nephrol 13:65-74. 2002
    Mutations in the MYH9 gene, which encodes the nonmuscle myosin heavy chain IIA, have been recently reported in three syndromes that share the association of macrothrombocytopenia (MTCP) and leukocyte inclusions: the May-Hegglin anomaly ..
  12. pmc Worldwide distribution of the MYH9 kidney disease susceptibility alleles and haplotypes: evidence of historical selection in Africa
    Taras K Oleksyk
    Department of Biology, University of Puerto Rico at Mayaguez, Mayaguez, Puerto Rico
    PLoS ONE 5:e11474. 2010
    b>MYH9 was recently identified as renal susceptibility gene (OR 3-8, p < 10(-8)) for major forms of kidney disease disproportionately affecting individuals of African descent...
  13. pmc MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis
    Jeffrey B Kopp
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 40:1175-84. 2008
    ..2 and a peak lod of 12.4 centered on MYH9, a functional candidate gene expressed in kidney podocytes...
  14. ncbi Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May-Hegglin anomaly
    M J Kelley
    Department of Medicine, Duke University, Durham, North Carolina, USA
    Nat Genet 26:106-8. 2000
    ..Here we screen a candidate gene in this region, encoding non-muscle myosin heavy chain A (MYH9), for mutations in ten families...
  15. ncbi Myosin IIA regulates cell motility and actomyosin-microtubule crosstalk
    Sharona Even-Ram
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research NIDCR, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Cell Biol 9:299-309. 2007
    ..We conclude that myosin IIA negatively regulates cell migration and suggest that it maintains a balance between the actomyosin and microtubule systems by regulating microtubule dynamics...
  16. doi Renal manifestations of patients with MYH9-related disorders
    Kyoung Hee Han
    Department of Pediatrics, Seoul National University Children s Hospital, 101 Daehang no, Jongno gu, Seoul, 110 744, South Korea
    Pediatr Nephrol 26:549-55. 2011
    b>MYH9-related disorders are a group of autosomal, dominantly inherited disorders caused by mutations of the MYH9 gene, which encodes the non-muscle myosin heavy chain IIA (NMMHC-IIA)...
  17. doi Glomerular MYH9 expression is reduced by HIV-1
    Thomas Hays
    Mount Sinai School of Medicine, Department of Medicine, New York, New York, USA
    AIDS 26:797-803. 2012
    ..Given that loss of MYH9 function causes a Mendelian renal disease, we hypothesized that renal expression of MYH9 is down-regulated by HIV-1 ..
  18. pmc Two functional S100A4 monomers are necessary for regulating nonmuscle myosin-IIA and HCT116 cell invasion
    Reniqua P House
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States
    Biochemistry 50:6920-32. 2011
    ....
  19. pmc Mechanism of the Ca²+-dependent interaction between S100A4 and tail fragments of nonmuscle myosin heavy chain IIA
    Sandip K Badyal
    Department of Biochemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, UK
    J Mol Biol 405:1004-26. 2011
    ....
  20. doi Identification of three in-frame deletion mutations in MYH9 disorders suggesting an important hot spot for small rearrangements in MYH9 exon 24
    Koji Miyazaki
    Department of Hematology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, 228 8555 Kanagawa, Japan
    Eur J Haematol 83:230-4. 2009
    b>MYH9 disorders include hereditary macrothrombocytopenias with leukocyte inclusion bodies...
  21. doi Heavy chain myosin 9-related disease (MYH9 -RD): neutrophil inclusions of myosin-9 as a pathognomonic sign of the disorder
    Anna Savoia
    Medical Genetics, Department of Reproductive and Developmental Sciences, IRCCS Burlo Garofolo, University of Trieste, Trieste, Italy
    Thromb Haemost 103:826-32. 2010
    b>MYH9-related disease ( MYH9-RD) is an autosomal dominant thrombocytopenia with giant platelets variably associated with young-adult onset of progressive sensorineural hearing loss, presenile cataract, and renal damage...
  22. pmc Multiple regulatory steps control mammalian nonmuscle myosin II assembly in live cells
    Mark T Breckenridge
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Mol Biol Cell 20:338-47. 2009
    ..This work furthermore offers cellular insights that help explain platelet and leukocyte defects associated with R1933-stop alleles of patients afflicted with human MYH9-related disorder.
  23. doi Patients with Epstein-Fechtner syndromes owing to MYH9 R702 mutations develop progressive proteinuric renal disease
    Takashi Sekine
    Faculty of Medicine, Department of Pediatrics, The University of Tokyo, Tokyo, Japan
    Kidney Int 78:207-14. 2010
    ..analyses of nondiabetic African-American patients with focal segmental glomerulosclerosis (FSGS) have identified MYH9, encoding nonmuscle myosin heavy chain IIA (NMMHC-IIA), as a gene having a critical role in this disease...
  24. ncbi Effect of Mts1 on the structure and activity of nonmuscle myosin II
    H L Ford
    Department of Biochemistry and Cancer Center, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Biochemistry 36:16321-7. 1997
    ..The data demonstrate an effect of Mts1 on both myosin structure and function, and suggest a route through which Mts1 affects motility as well as metastasis...
  25. doi Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with the progression of IgA nephropathy in Chinese
    Wenrong Cheng
    Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, and Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, People s Republic of China
    Nephrol Dial Transplant 26:2544-9. 2011
    ..A recent genome-wide association study (GWAS) indicated that the MYH9 gene was significantly associated with non-diabetic ESRD in African-Americans and also influenced kidney function ..
  26. doi Identification of the first duplication in MYH9-related disease: a hot spot for unequal crossing-over within exon 24 of the MYH9 gene
    Daniela De Rocco
    Medical Genetics, Department of Reproductive and Developmental Sciences, Institute for Maternal and Child Health IRCCS Burlo Garofolo, University of Trieste, Via dell Istria 65 1, 34137 Trieste, Italy
    Eur J Med Genet 52:191-4. 2009
    b>MYH9-related disease (MYH9RD) is a rare autosomal dominant disorder caused by mutations in MYH9, the gene encoding the heavy chain of non-muscle myosin IIA...
  27. ncbi Identification of six novel MYH9 mutations and genotype-phenotype relationships in autosomal dominant macrothrombocytopenia with leukocyte inclusions
    S Kunishima
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    J Hum Genet 46:722-9. 2001
    ..3-q13.2 and the disease gene was recently identified as MYH9, the gene encoding the nonmuscle myosin heavy chain-A...
  28. doi Nonmuscle myosin IIA is required for lamellipodia formation through binding to WAVE2 and phosphatidylinositol 3,4,5-triphosphate
    Shigeru Morimura
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama 241 0815, Japan
    Biochem Biophys Res Commun 404:834-40. 2011
    ..We identified p250 as nonmuscle myosin IIA heavy chain (MYH9) by mass spectrometry and immunoblot analysis using anti-MYH9 antibody...
  29. doi Identification and characterization of the first large deletion of the MYH9 gene associated with MYH9 disorders
    Shinji Kunishima
    Department of Hemostasis and Thrombosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    Eur J Haematol 80:540-4. 2008
    b>MYH9 disorders are autosomal dominant macrothrombocytopenias with leukocyte inclusion bodies. Single point mutations in the protein-coding sequence of the MYH9 gene are the most common cause...
  30. ncbi Application of a diagnostic algorithm for inherited thrombocytopenias to 46 consecutive patients
    Patrizia Noris
    Department of Internal Medicine, IRCCS Policlinico San Matteo University of Pavia, Italy
    Haematologica 89:1219-25. 2004
    ..The aim of the present study was to validate this diagnostic algorithm by applying it to a case series of genetic thrombocytopenias...
  31. pmc Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion
    Brian A Babbin
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    Am J Pathol 174:436-48. 2009
    ..These observations indicate multiple functions for NM IIA, which, along with the regulation of the F-actin cytoskeleton and cell-matrix adhesions, involve previously unrecognized control of intracellular signaling and protein expression...
  32. ncbi Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes
    M Simons
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    Circ Res 69:530-9. 1991
    ..Comparison of this sequence to cDNA clones encoding the amino-terminal one third of the NMMHC-B sequence (amino acids 58-718) shows them to be 89% identical at the amino acid level and 74% identical at the nucleotide level...
  33. pmc Nonmuscle myosin heavy chain IIA mutations define a spectrum of autosomal dominant macrothrombocytopenias: May-Hegglin anomaly and Fechtner, Sebastian, Epstein, and Alport-like syndromes
    K E Heath
    Department of Human Genetics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Hum Genet 69:1033-45. 2001
    ..Previously, mutations in the nonmuscle myosin heavy chain 9 gene (MYH9), which encodes nonmuscle myosin heavy chain IIA (MYHIIA), were identified in all three ..
  34. ncbi Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration
    Joshua C Sandquist
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 281:35873-83. 2006
    ..Our data suggest that the myosin IIA and IIB isoforms are regulated by different signaling pathways to perform distinct cellular activities and that myosin IIA is preferentially required for Rho-mediated contractile functions...
  35. pmc Myosin-IIA heavy-chain phosphorylation regulates the motility of MDA-MB-231 carcinoma cells
    Natalya G Dulyaninova
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Biol Cell 18:3144-55. 2007
    ..In contrast, cells expressing the S1943A mutant exhibited reduced migration and lamellipod extension. These observations support a direct role for myosin-IIA heavy-chain phosphorylation in mediating motility and chemotaxis...
  36. ncbi Regulation of myosin-IIA assembly and Mts1 binding by heavy chain phosphorylation
    Natalya G Dulyaninova
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 44:6867-76. 2005
    ....
  37. ncbi Immunofluorescence analysis of neutrophil nonmuscle myosin heavy chain-A in MYH9 disorders: association of subcellular localization with MYH9 mutations
    Shinji Kunishima
    Japanese Red Cross Aichi Blood Center, Seto, Japan
    Lab Invest 83:115-22. 2003
    ..disorders are caused by mutations in the same gene, the MYH9, which encodes the nonmuscle myosin heavy chain-A (NMMHCA)...
  38. ncbi Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes. The May-Heggllin/Fechtner Syndrome Consortium
    M Seri
    Laboratory of Molecular Genetics, Institute G Gaslini, Genoa, Italy
    Nat Genet 26:103-5. 2000
    ..Among the identified candidate genes is the gene encoding nonmuscle myosin heavy chain 9 (MYH9; refs 8-10), which is expressed in platelets and upregulated during granulocyte differentiation...
  39. pmc Gene-gene and gene-environment interactions in HIV-associated nephropathy: A focus on the MYH9 nephropathy susceptibility gene
    Marina Nunez
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Adv Chronic Kidney Dis 17:44-51. 2010
    ..Although polymorphisms in the MYH9 gene on chromosome 22 are strongly associated with HIVAN, as well as with idiopathic focal segmental ..
  40. pmc Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans
    Barry I Freedman
    Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 75:736-45. 2009
    ..showed strong association with idiopathic and HIV-related focal segmental glomerulosclerosis and non-muscle myosin heavy chain 9 (MYH9) gene polymorphisms in this ethnic group, we tested for MYH9 associations in a variety of kidney ..
  41. doi Differential expression of wild-type and mutant NMMHC-IIA polypeptides in blood cells suggests cell-specific regulation mechanisms in MYH9 disorders
    Shinji Kunishima
    Department of Hemostasis and Thrombosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    Blood 111:3015-23. 2008
    b>MYH9 disorders such as May-Hegglin anomaly are characterized by macrothrombocytopenia and cytoplasmic granulocyte inclusion bodies that result from mutations in MYH9, the gene for nonmuscle myosin heavy chain-IIA (NMMHC-IIA)...
  42. pmc Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin
    R L Shoeman
    Max Planck Institut für Zellbiologie, Ladenburg, Federal Republic of Germany
    Am J Pathol 142:221-30. 1993
    ..Nonmuscle myosin heavy chains were also cleaved by this enzyme in vitro. These data demonstrate that this protease can cause alterations in muscle cell ultrastructure in vitro that may be of clinical relevance in infected individuals...
  43. ncbi Interaction of metastasis-inducing S100A4 protein in vivo by fluorescence lifetime imaging microscopy
    Shu Zhang
    Cancer and Polio Research Fund Laboratories, School of Biological Sciences, University of Liverpool, Liverpool, L69 7ZB, UK
    Eur Biophys J 34:19-27. 2005
    ....
  44. ncbi Cloning of the murine non-muscle myosin heavy chain IIA gene ortholog of human MYH9 responsible for May-Hegglin, Sebastian, Fechtner, and Epstein syndromes
    Maria D'Apolito
    Servizio di Genetica Medica, IRCCS Ospedale CSS, I 71013 San Giovanni Rotondo, Foggia, Italy
    Gene 286:215-22. 2002
    Mutations in the non-muscle myosin heavy chain IIA gene (MYH9) are responsible for May-Hegglin anomaly, Sebastian, Fechtner and Epstein syndromes...
  45. ncbi A single class II myosin modulates T cell motility and stopping, but not synapse formation
    Jordan Jacobelli
    Department of Pathology, University of California at San Francisco, 513 Parnassus Ave, San Francisco, California 93143, USA
    Nat Immunol 5:531-8. 2004
    ..Here we show that nonmuscle myosin heavy chain IIA, or MyH9, is the only class II myosin expressed in T cells and is associated with the uropod during crawling...
  46. doi Genome-wide linkage analysis of serum creatinine in three isolated European populations
    Cristian Pattaro
    Institute of Genetic Medicine, European Academy Bozen Bolzano EURAC, Bolzano, Italy
    Kidney Int 76:297-306. 2009
    ..and hypertension, was detected over a region containing the non-muscle myosin heavy chain type II isoform A (MYH9) gene (LOD score=3.52)...
  47. pmc Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD
    Barry I Freedman
    1Internal Medicine Nephrology, 2Biochemistry, 3Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 24:3366-71. 2009
    Although MYH9 is strongly associated with biopsy-proven idiopathic and HIV-associated focal segmental glomerulosclerosis (FSGS) and clinically diagnosed 'hypertension-associated' end-stage renal disease (ESRD) in African Americans, its ..
  48. ncbi Non-muscle myosin heavy chain IIA and IIB interact and co-localize in living cells: relevance for MYH9-related disease
    Monica Marini
    Laboratory of Molecular Genetics, G Gaslini Institute, 16147 Genova, Italy
    Int J Mol Med 17:729-36. 2006
    ..This argument is relevant not only to cell physiology, but also to human pathology since mutations of the MYH9 gene encoding non-muscle myosin heavy chain II A (NMMHC-A) cause MYH9-related disease (MYH9-RD), an autosomal ..
  49. ncbi Myosin is an in vivo substrate of the protein tyrosine phosphatase (SHP-1) after mIgM cross-linking
    Takeshi Baba
    Research Institute for Biological Sciences, Tokyo University of Science, 2669 Yamazaki, Noda, 278 0022, Chiba, Japan
    Biochem Biophys Res Commun 304:67-72. 2003
    ..Thus, myosin is a direct SHP-1 substrate in B cells. The results suggest that SHP-1 plays a critical role in the reorganization of cytoskeletal architecture mediated via BCR stimulation...
  50. pmc Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with albuminuria in hypertensive African Americans: the HyperGEN study
    Barry I Freedman
    Section on Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Nephrol 29:626-32. 2009
    b>MYH9 is a podocyte-expressed gene encoding nonmuscle myosin IIA that is associated with idiopathic and human immunodeficiency virus-associated focal segmental glomerulosclerosis (FSGS) and hypertensive end-stage renal disease in African ..
  51. pmc Genetics of focal segmental glomerulosclerosis and human immunodeficiency virus-associated collapsing glomerulopathy: the role of MYH9 genetic variation
    Cheryl A Winkler
    Scientific Applications International Corporation Frederick, Inc, Laboratory of Genomic Diversity, Center for Cancer Research, National Cancer Institute Frederick, National Institutes of Health, Frederick, MD, USA
    Semin Nephrol 30:111-25. 2010
    ..Admixture mapping identified genetic variants in the nonmuscle myosin heavy chain 9 gene (MYH9) as having a major influence on both FSGS and human immunodeficiency virus-associated collapsing ..
  52. doi Identification of the first in cis mutations in MYH9 disorder
    Yuji Miyajima
    Department of Pediatrics, Anjo Kosei Hospital, Anjo, Aichi, Japan
    Eur J Haematol 82:288-91. 2009
    Here, we report the first in cis mutations in exon 1 of the MYH9 gene in a patient with MYH9 disorder. The patient was a 5-yr-old girl with macrothrombocytopenia and conspicuous cytoplasmic inclusion bodies in neutrophils...
  53. ncbi Differential localization of myosin-II isozymes in human cultured cells and blood cells
    P Maupin
    Department of Cell Biology and Anatomy, Johns Hopkins Medical School, Baltimore, MD 21205 2196
    J Cell Sci 107:3077-90. 1994
    ..The superimposition of these small spots concentrated in the cleavage furrow produces the intense, uniform staining observed in conventional micrographs of whole cells...
  54. pmc Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells
    Richard K Tsai
    Biophysical Engineering Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 180:989-1003. 2008
    ..A point mutation turns off this motor's contribution to phagocytosis, suggesting that self-recognition inhibits contractile engulfment...
  55. ncbi Vertebrate nonmuscle myosin II isoforms rescue small interfering RNA-induced defects in COS-7 cell cytokinesis
    Jianjun Bao
    Laboratory of Molecular Cardiology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:19594-9. 2005
    ....
  56. ncbi Immunocytochemistry for the heavy chain of the non-muscle myosin IIA as a diagnostic tool for MYH9-related disorders
    Alessandro Pecci
    Department of Internal Medicine, IRCCS San Matteo, University of Pavia, Italy
    Br J Haematol 117:164-7. 2002
    ..We investigated the NMMHC-A localization in blood cells from eight MHA, SBS or FTNS patients with known MYH9 mutations...
  57. ncbi Pathogenetic mechanisms of hematological abnormalities of patients with MYH9 mutations
    Alessandro Pecci
    Department of Internal Medicine, University of Pavia, Italy
    Hum Mol Genet 14:3169-78. 2005
    Mutations of MYH9, the gene for non-muscle myosin heavy chain IIA (NMMHC-IIA), cause a complex clinical phenotype characterized by macrothrombocytopenia and granulocyte inclusion bodies, often associated with deafness, cataracts and/or ..
  58. pmc Conditional expression of a truncated fragment of nonmuscle myosin II-A alters cell shape but not cytokinesis in HeLa cells
    Q Wei
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Biol Cell 11:3617-27. 2000
    ....
  59. ncbi Induction of nonmuscle myosin heavy chain II-C by butyrate in RAW 264.7 mouse macrophages
    Denis B Buxton
    Laboratory of Molecular Cardiology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:15449-55. 2003
    ..8-Bromo-cGMP had no effect on nonmuscle myosin heavy chain induction, consistent with a cGMP-independent mechanism for nitric oxide-mediated inhibition of nonmuscle myosin heavy chain II-C induction...
  60. ncbi Increased expression of non-muscle myosin heavy chain-B in connective tissue cells of hypertrophic rat urinary bladder
    R Sjuve
    Department of Physiological Sciences, Lund University, Sweden
    Cell Tissue Res 304:271-8. 2001
    ..The NM-MHC-B-positive cells could have a role in the production of extracellular matrix and growth factors or be involved in modulation of spontaneous contractile activity...
  61. ncbi Ablation and mutation of nonmuscle myosin heavy chain II-B results in a defect in cardiac myocyte cytokinesis
    Kazuyo Takeda
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1762, USA
    Circ Res 93:330-7. 2003
    ..Whereas cardiac myocytes completely ablated for NMHC II-B show enlargement and binucleation, mice expressing as little as 6% of the normal amount of wild-type NMHC II-B in the heart do not show these abnormalities...
  62. ncbi Expression of non-muscle myosin heavy chain in rat heart after immunosuppressive treatment
    Rita Rezzani
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnologies, University of Brescia, V le Europa 11, 25123, Brescia, Italy
    Int Immunopharmacol 6:962-7. 2006
    ..This could be explained as a tentative of cardiac tissue to maintain the structural integrity of intercalated disks and so the contraction/relaxation process...
  63. ncbi IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression during phorbol ester-induced promyelocytic HL-60 differentiation
    Myung Chul Chung
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute NIH, 10 Center Drive, Bethesda, MD 20892, USA
    J Biol Chem 279:56042-52. 2004
    ..Together, these results indicate that IRF-2 contributes to transcriptional activation of the NMHC-A gene via 32kb-150 during TPA-induced differentiation of HL-60 cells...
  64. ncbi Transforming growth factor-beta1 regulates cell growth and causes downregulation of SMemb/non-muscle myosin heavy chain B mRNA in human prostate stromal cells
    Kenji Obara
    Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Scand J Urol Nephrol 39:366-71. 2005
    ..The expression of the SM2 isoform of smooth muscle myosin heavy chain (SMMHC) mRNA was also examined...
  65. ncbi Differential expression of non-muscle myosin heavy chain genes during Xenopus embryogenesis
    N Bhatia-Dey
    Laboratory of Molecular Cardiology, National Heart Lung and Blood Institute, Bethesda, MD, USA
    Mech Dev 78:33-6. 1998
    ....
  66. ncbi Minor histocompatibility antigen-specific cytotoxic T lymphocytes generated with dendritic cells from DLA-identical littermates
    George E Georges
    Department of Medicine, University of Washington, Seattle, Washington 98109 1024, USA
    Biol Blood Marrow Transplant 9:234-42. 2003
    Donor cytotoxic T lymphocytes (CTL) specific for minor histocompatibility antigens (mHA) mediate the graft-versus-host effect whereas host mHA-specific CTL mediate graft rejection in the setting of major histocompatibility complex ..
  67. pmc MYH9 genetic variants associated with glomerular disease: what is the role for genetic testing?
    Jeffrey B Kopp
    Kidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1268, USA
    Semin Nephrol 30:409-17. 2010
    Genetic variation in MYH9, encoding nonmuscle myosin IIA heavy chain, has been associated recently with increased risk for kidney disease...
  68. ncbi Cloning and developmental expression of nonmuscle myosin IIA (Myh9) in the mammalian inner ear
    Anand N Mhatre
    Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
    J Neurosci Res 76:296-305. 2004
    b>MYH9 encoding a nonmuscle myosin heavy chain has been linked to nonsyndromic and syndromic forms of autosomal dominant hereditary hearing loss, suggesting a critical biological role of this motor protein in the auditory organ...
  69. pmc The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway
    Zhao Chen
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    Blood 110:171-9. 2007
    The gene implicated in the May-Hegglin anomaly and related macrothrombocytopenias, MYH9, encodes myosin-IIA, a protein that enables morphogenesis in diverse cell types...
  70. ncbi [A non-familial May-Hegglin anomaly accompanying with MYH9 gene R1933X mutation and I1626V polymorphism]
    Ying Li
    Department of Hematology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhonghua Xue Ye Xue Za Zhi 30:577-81. 2009
    To identify the nonmuscle myosin heavy chain 9 (MYH9) gene mutation site in a May-Hegglin anomaly(MHA) patient, and to analyze the genotype of her relatives to exclude the inherit correlation between the proband and her family members.
  71. ncbi [Usefulness of immunofluorescence analysis of neutrophil nonmuscle myosin heavy chain-A for diagnosing in two sisters with May-Hegglin anomaly]
    Noriko Kimura
    Department of Laboratory Medicine, Nara City Hospital, Japan
    Rinsho Ketsueki 49:1614-8. 2008
    ..MHA is caused by mutations in the MYH9 gene, which encodes the nonmuscle mysosin heavy chain-A (NMMCH-A)...
  72. ncbi A notable case report of May-Hegglin anomaly with immune complex-related nephropathy: a genetic and histological analysis
    Y Ohtsuka
    Department of Pediatrics, Faculty of Medicine, Saga University, Saga City, Japan
    Clin Nephrol 75:255-62. 2011
    ..Mutations in the MYH9 gene, encoding non-muscle myosin heavy chain IIA (NMMHC-IIA) have been identified in patients with MHA and other ..
  73. ncbi Kappa immunoglobulin light chain polymorphisms and survival after allogeneic transplantation for B-cell malignancies: a potential graft-vs-leukaemia target
    T L Etto
    Bone Marrow Transplant Programme, Alfred Hospital, Melbourne, Australia
    Tissue Antigens 69:56-61. 2007
    ..antigen (HLA)-matched haematopoietic stem cell transplantation (HSCT) setting, minor histocompatibility antigen (mHA) disparities between recipient and donor can lead to graft-vs-host disease (GVHD) or graft rejection...
  74. ncbi Expression of Myh9 in the mammalian cochlea: localization within the stereocilia
    Anand N Mhatre
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci Res 84:809-18. 2006
    Mutations of non-muscle myosin Type IIA or MYH9 are linked to syndromic or nonsyndromic hearing loss. The biologic function of MYH9 in the auditory organ and the pathophysiology of its dysfunction remain to be determined...
  75. doi Plasma from a case of recurrent idiopathic FSGS perturbs non-muscle myosin IIA (MYH9 protein) in human podocytes
    Sima Babayeva
    Department of Medicine, McGill University, 3775 University Street, Montreal, QC, H3A2B4, Canada
    Pediatr Nephrol 26:1071-81. 2011
    The MYH9 gene encodes a non-muscle myosin IIA heavy chain (NMMHC-IIA) expressed in podocytes...
  76. pmc Regulated proteolysis of nonmuscle myosin IIA stimulates osteoclast fusion
    Brooke K McMichael
    Department of Physiology and Cell Biology, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    J Biol Chem 284:12266-75. 2009
    The nonmuscle myosin IIA heavy chain (Myh9) is strongly associated with adhesion structures of osteoclasts...
  77. ncbi Menière's disease as a late manifestation of congenital syphilis
    F Indesteege
    ENT Department, Middelheim General Hospital, Antwerp, Belgium
    Acta Otorhinolaryngol Belg 43:327-33. 1989
    ..The value of a positive serological test (FTA - ABS or MHA - T.P.) in the presence of inner-ear symptoms is discussed.
  78. pmc Evaluation of an enzyme immunoassay technique for detection of antibodies against Treponema pallidum
    Rita Castro
    Unidade de Doenças Sexualmente Transmitidas, Centro de Malaria e Outras Doencas Tropicais, Instituto de Higiene e Medicina Tropical, Lisbon, Portugal
    J Clin Microbiol 41:250-3. 2003
    ..were 100 and 93%, respectively, compared with the results of a microhemagglutination assay for Treponema pallidum (MHA-TP) and 99...
  79. pmc Of mice and men: Relevance of cellular and molecular characterizations of myosin IIA to MYH9-related human disease
    Sharona Even-Ram
    The Stem Cell Center, Goldyn Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    Cell Adh Migr 1:152-5. 2007
    ..In humans, various mutations in the MYH9 gene that encodes the myosin IIA heavy chain cause autosomal dominant disease, whereas in mice, the complete ..
  80. ncbi Floccular modulation of vestibuloocular pathways and cerebellum-related plasticity: An in vitro whole brain study
    A L Babalian
    Laboratoire de la Neurobiologie des Réseaux Sensorimoteures, Centre National de la Recherche Scientifique, 75270 Paris Cedex 06, France
    J Neurophysiol 84:2514-28. 2000
    ..responses in abducens and oculomotor nerves and abducens nucleus; for identification of flocculus target neurons (FTNs) in the vestibular nuclei and intracellular study of some of their physiological properties; to search for possible ..
  81. ncbi Use of a novel serum ELISA method and the tonsil-carrier state for evaluation of Mycoplasma hyosynoviae distributions in pig herds with or without clinical arthritis
    Elisabeth Okholm Nielsen
    The National Committee for Pig Production, Danish Bacon and Meat Council, Axeltorv 3, 1609 Copenhagen V, Denmark
    Vet Microbiol 111:41-50. 2005
    ..hyosynoviae arthritis (MhA herds, n = 4) and in herds with M...
  82. doi MYH9 related disease: four novel mutations of the tail domain of myosin-9 correlating with a mild clinical phenotype
    Alessandro Pecci
    Department of Internal Medicine, University of Pavia and IRCCS Policlinico San Matteo Foundation, Pavia
    Eur J Haematol 84:291-7. 2010
    b>MYH9-related disease (MYH9-RD) is a rare autosomal dominant disorder caused by mutations in MYH9, the gene encoding the heavy chain of non-muscle myosin IIA...
  83. ncbi [Expression and function of non-muscle myosin-IIA in Fechtner syndrome]
    Hai yan Yang
    Ministry of Health, Jiangsu Institute of Hematology, The First Hospital of Suzhou University, Suzhou 215006, Jiagnsu Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:871-4. 2008
    ..IIA and IIB show obvious interaction, IIB partly compensates the IIA defect derived from MYH9 mutations, and may delay or prevent the development of clinically relevant abnormalities.
  84. pmc MicroRNA let-7f inhibits tumor invasion and metastasis by targeting MYH9 in human gastric cancer
    Shuli Liang
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital of Digestive Diseases, Xi an, China
    PLoS ONE 6:e18409. 2011
    ..In this study, we investigate whether let-7f acts as a tumor suppressor to inhibit invasion and metastasis in gastric cancers...
  85. ncbi [Performance of different methods of oxacillin resistance detection in atypic strains of Staphylococcus aureus]
    F Hamdad
    Service de Bacteriologie Hygiene, CHU d Amiens, France
    Pathol Biol (Paris) 54:447-52. 2006
    ..The diffusion method using the 5 microg oxacillin and 30 microg cefoxitin discs on Mueller-Hinton Agar (MHA) with and without NaCl, the incubation at 35 degrees C or 30 degrees C for 24 or 48 hours respectively, and the ..
  86. ncbi Cerebrospinal fluid treponemal antibodies in untreated early syphilis
    C M Marra
    Department of Medicine, University of Washington, Seattle
    Arch Neurol 52:68-72. 1995
    ..cell count, protein, VDRL test, and antibodies to Treponema pallidum by microhemagglutination test for T pallidum (MHA-TP) and fluorescent treponemal antibody absorption test (FTA-ABS); albumin ratio; and IgG index...
  87. ncbi On-column derivatization-capillary electrochromatography with o-phthalaldehyde/alkylthiol for assay of biogenic amines
    Shigeyuki Oguri
    Laboratory of Food Science, Department of Home Economics, Aichi Gakusen University, 28 Kamikawanari, Hegoshi cho, Okazaki City 444 8520, Japan
    J Chromatogr A 1044:271-6. 2004
    The elution behaviors of the biogenic amines, histamine (HA) and its metabolite methyl histamine (MHA), were evaluated by means of on-column derivatization (OCD)-capillary electrochromatography (CEC) which employed a monolithic ..
  88. ncbi The degradation of haem by carbon tetrachloride: metabolic activation requires a free axial coordination site on the haem iron and electron donation
    M Manno
    Biochemical Pharmacology Section, Toxicology Unit, Medical Research Council Laboratories, Surrey, UK
    Xenobiotica 19:1023-35. 1989
    ..of carbon tetrachloride (CCl4) in vitro has been investigated under anaerobic conditions, using methaemalbumin (MHA) and either sodium dithionite or NADPH together with NADPH-cytochrome P-450 reductase (EC 1.6.2...
  89. ncbi Prevalence of neurosyphilis in human immunodeficiency virus-infected patients with latent syphilis
    P D Holtom
    Los Angeles County University of Southern California Medical Center 90033
    Am J Med 93:9-12. 1992
    ..with latent syphilis (reactive serum rapid plasma reagin [RPR] and microhemagglutination-Treponema pallidum [MHA-TP])...
  90. ncbi [Comparison of susceptibilities for fosfomycin determined by various methods in clinical isolates in 2003 -2004]
    Hideaki Muramatsu
    Hamamatsu University School of Medicine
    Jpn J Antibiot 60:107-24. 2007
    ..and sulfamethoxazole/trimethoprim were determined by an agar dilution method using Mueller-Hinton agar (MHA) in Escherichia coli, Klebsiella spp., Serratia marcescens, Citrobacter spp., Enterobacter spp...
  91. pmc Diverse patterns of T-cell response against multiple newly identified human Y chromosome-encoded minor histocompatibility epitopes
    Yishai Ofran
    Division of Hematologic Malignancies, Cancer Vaccine Center, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 16:1642-51. 2010
    Donor T cells respond to minor histocompatibility antigens (mHA), resulting in both graft-versus-host disease and graft versus leukemia after allogeneic hematopoietic stem cell transplantation...
  92. ncbi Viscum album agglutinin-I induces degradation of cytoskeletal proteins in leukaemia PLB-985 cells differentiated toward neutrophils: cleavage of non-muscle myosin heavy chain-IIA by caspases
    Valérie Lavastre
    INRS Institut Armand Frappier, Universite du Quebec, Pointe Claire, QC, Canada
    Br J Haematol 138:545-54. 2007
    ..Therefore, PLB-985D cells may provide a suitable substitute for neutrophils in screening experiments, preventing extensive neutrophil cell isolation...
  93. ncbi Evaluation of the Treponema pallidum particle agglutination technique (TP.PA) in the diagnosis of neurosyphilis
    Rita Castro
    Unidade de Doenças Sexualmente Transmitidas Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal
    J Clin Lab Anal 20:233-8. 2006
    ..Venereal Disease Research Laboratory (VDRL) test, microhemagglutination assay for Treponema pallidum antibodies (MHA-TP), and fluorescent treponemal antibody-ABS (FTA-Abs) test for the diagnosis of neurosyphilis...
  94. pmc Improved detection of vanB2-containing enterococcus faecium with vancomycin susceptibility by Etest using oxgall supplementation
    E A Grabsch
    Microbiology Department, Austin Hospital, Studley Rd, Heidelberg, Victoria, Australia
    J Clin Microbiol 46:1961-4. 2008
    ..Etest detection of LM-VRE improved when Mueller-Hinton agar (MHA) and brain heart infusion agar (BHIA) were supplemented with 10 g/liter oxgall (MHA-Oxg and BHIA-Oxg, respectively)...
  95. ncbi Recent advances in molecular pharmacology of the histamine systems: organic cation transporters as a histamine transporter and histamine metabolism
    Masahito Ogasawara
    Division of Pharmacology, Department of Integrated Basic Medical Science, Ehime University School of Medicine, Toon, Japan
    J Pharmacol Sci 101:24-30. 2006
    ..After 60-min incubation of these cells with PBS including HA (100 microM), N(tau)-methylhistamine (MHA) concentration of the supernatants was determined by the HPLC-fluorometry method...
  96. ncbi The nucleoprotein of Pichinde virus expressed by a vaccinia-Pichinde virus recombinant partially protects hamsters from lethal virus challenge
    D Y Ozols
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Arch Virol 139:23-36. 1994
    Syrian hamsters, strain MHA/Lak, are susceptible to intraperitoneal infection with Pichinde virus and die from an overwhelming viremia...
  97. doi Dental implants placed in extraction sites grafted with different bone substitutes: radiographic evaluation at 24 months
    Roberto Crespi
    Department of Dentistry, Vita Salute University, San Raffaele Hospital, Milan, Italy
    J Periodontol 80:1616-21. 2009
    ..The aim of this study was to evaluate radiographic parameters of implants positioned in grafted alveoli with three different biomaterials: magnesium-enriched hydroxyapatite (MHA), calcium sulfate (CS), and heterologous porcine bone (PB).
  98. ncbi Treponemal specific tests for the serodiagnosis of syphilis. Syphilis and HIV Study Group
    M Augenbraun
    SUNY Health Science Center at Brooklyn, New York 11203, USA augenm23Ahscbklyn edu
    Sex Transm Dis 25:549-52. 1998
    OBJECTIVES: To determine the rate of concordance of the Microhemagglutination Assay for Antibodies to T. pallidum (MHA-TP) and the Fluorescent Treponemal Antibody-Absorption test (FTA-ABS) prior to therapy in patients with early stage ..
  99. ncbi Is the direct quantitation of antibiotics in agar by high-performance liquid chromatography useful?
    C Arcelloni
    Laboratory of Chromatography and Separative Techniques, IRCCS H S Raffaele, Milan, Italy
    J Chromatogr A 812:111-6. 1998
    ..Mueller-Hinton agar (MHA) plates from three manufacturers were tested using HPLC and the disc diffusion test of ceftazidime (CAZ)...
  100. ncbi Rumen degradation and availability of various amounts of liquid methionine hydroxy analog in lactating dairy cows
    K M Koenig
    Agriculture and Agri Food Canada, Research Centre, Lethbridge, AB
    J Dairy Sci 85:930-8. 2002
    ..2 g of a dry calcium salt of the analog (86% HMB; MHA) mixed with 0.5 kg of ground barley grain...
  101. pmc Evaluation of the Etest method for determining fluconazole susceptibilities of 402 clinical yeast isolates by using three different agar media
    M A Pfaller
    Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Microbiol 36:2586-9. 1998
    ..MICs were determined with RPMI agar containing 2% glucose (RPG), Casitone agar (CAS), and Mueller-Hinton agar (MHA) and were read after incubation for 48 h at 35 degrees C...

Research Grants66

  1. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh Shivdasani; Fiscal Year: 2009
    ..biological studies, genetic analysis in mice, and appreciation of congenital human thrombocytopenias such as the Myh9- related disorders...
  2. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh A Shivdasani; Fiscal Year: 2010
    ..biological studies, genetic analysis in mice, and appreciation of congenital human thrombocytopenias such as the Myh9- related disorders...
  3. Identifying the earliest events in HIV-1 associated nephropathy via genome-wide
    Ali G Gharavi; Fiscal Year: 2010
    ..to HIVAN has complex determination, with significant contribution from genetic variation in the nonmuscle myosin heavy chain 9 (MYH9), a podocyte expressed gene...
  4. Basic FGF Low Affinity Receptors in HIVAN
    PATRICIO ERNESTO RAY; Fiscal Year: 2010
    ..screened for the presence of the HIV-genome, HBGF, HSPG, and genotyped to characterize a genetic variation in the MYH9 gene, encoding the non-muscle myosin IIA heavy chain, that is associated with HIV-collapsing glomerulopathy in ..
  5. Microarray Analysis of H-Y Antibodies in Human Transplantation
    David Miklos; Fiscal Year: 2007
    ..hematopoietic transplantation induces clinically relevant B-cell responses to minor histocompatibility antigens (mHA)...
  6. Identification of Minor Histocompatibility Antigens
    David Miklos; Fiscal Year: 2006
    Minor histocompatibility antigens (mHA) are peptides derived from normal cellular proteins that are presented by major histocompatibility antigen (MHC) class I and class H molecules...
  7. Alloimmunization to mHAs by RBC Transfusion
    JAMES ZIMRING; Fiscal Year: 2007
    ..provides a mechanism by which chronic transfusion of even stringently leukoreduced RBC may result in sufficient mHA immunization to increase the frequency of BMT rejection...
  8. IMMUNOGENETICS OF MARROW ALLOGRAFTING
    John Hansen; Fiscal Year: 2006
    ..and the definition of optimal criteria for donor selection, on the identification of minor histocompatability (mHA) that function as peptide ligands for alloreactive T cells, and on the development of new strategies for inducing ..
  9. Cellular Regulation of a Myosin II Heavy Chain Kinase
    Paul Steimle; Fiscal Year: 2006
    ..in myosin II bipolar filament assembly can lead to the development of pathologies such as platelet malformation and kidney function defects, associated with a set of human genetic diseases, collectively called MYH9-related disorders.
  10. Improving Inpatient Psychiatric Payment: Cost and Quality Implications
    DONALD MICHAEL STEINWACHS; Fiscal Year: 2010
    ..the State of Maryland Health Services Cost Review Commission (HSCRC) and Maryland Mental Hygiene Administration (MHA)...
  11. Maryland Science to Service for Children and Families
    ALBERT ZACHIK; Fiscal Year: 2003
    ..This grant will expand the capacity of the Mental Hygiene Administration (MHA)-sponsored Systems Evaluation Center at the University of Maryland Department of Psychiatry - which is already ..
  12. HISPANIC COR: TRAINING IN BIOPSYCHOSOCIAL RESEARCH
    Guillermo Bernal; Fiscal Year: 2007
    ..orogram is based on the need to produce qualified researchers that can address the mental health and HIV/AIDS(MHA)-related problems facing contemporary society...
  13. Hispanic COR:Training in Biopsychosocial Research
    Guillermo Bernal; Fiscal Year: 2006
    ..program is based on the need to produce qualified researchers who can address the mental health and HIV-AIDS (MHA) problems of contemporary society...
  14. Improving Inpatient Psychiatric Payment: Cost and Quality Implications
    Donald Steinwachs; Fiscal Year: 2007
    ..the State of Maryland Health Services Cost Review Commission (HSCRC) and Maryland Mental Hygiene Administration (MHA)...
  15. OCULOMOTOR SYSTEM--NEURAL STRUCTURE AND FUNCTION
    William King; Fiscal Year: 1999
    ..neurons of the VOR are secondary vestibular neurons (currently called PVP units) and flocculus target neurons (FTNs)...