MYH9

Summary

Gene Symbol: MYH9
Description: myosin, heavy chain 9, non-muscle
Alias: BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHC-IIA, NMMHCA, cellular myosin heavy chain, type A, non-muscle myosin heavy chain A, non-muscle myosin heavy chain IIa, non-muscle myosin heavy polypeptide 9, nonmuscle myosin heavy chain II-A
Species: human

Top Publications

  1. ncbi Mts1 regulates the assembly of nonmuscle myosin-IIA
    Zhong hua Li
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 42:14258-66. 2003
  2. doi Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1
    Jun Arii
    Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Nature 467:859-62. 2010
  3. pmc Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration
    Nicole A Morin
    Department of Surgery, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
    J Exp Med 205:195-205. 2008
  4. doi Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with the progression of IgA nephropathy in Chinese
    Wenrong Cheng
    Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, and Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, People s Republic of China
    Nephrol Dial Transplant 26:2544-9. 2011
  5. doi Identification of three in-frame deletion mutations in MYH9 disorders suggesting an important hot spot for small rearrangements in MYH9 exon 24
    Koji Miyazaki
    Department of Hematology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, 228 8555 Kanagawa, Japan
    Eur J Haematol 83:230-4. 2009
  6. pmc Glomerular MYH9 expression is reduced by HIV-1
    Thomas Hays
    Mount Sinai School of Medicine, Department of Medicine, New York, New York, USA
    AIDS 26:797-803. 2012
  7. pmc MicroRNA let-7f inhibits tumor invasion and metastasis by targeting MYH9 in human gastric cancer
    Shuli Liang
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital of Digestive Diseases, Xi an, China
    PLoS ONE 6:e18409. 2011
  8. doi Patients with Epstein-Fechtner syndromes owing to MYH9 R702 mutations develop progressive proteinuric renal disease
    Takashi Sekine
    Faculty of Medicine, Department of Pediatrics, The University of Tokyo, Tokyo, Japan
    Kidney Int 78:207-14. 2010
  9. ncbi Myosin IIA regulates cell motility and actomyosin-microtubule crosstalk
    Sharona Even-Ram
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research NIDCR, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Cell Biol 9:299-309. 2007
  10. pmc Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis
    C P Lin
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Genes Immun 13:232-8. 2012

Detail Information

Publications204 found, 100 shown here

  1. ncbi Mts1 regulates the assembly of nonmuscle myosin-IIA
    Zhong hua Li
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 42:14258-66. 2003
    ..Altogether, these observations are consistent with mts1 regulating myosin IIA assembly by monomer sequestration and suggest that mts1 regulates cell shape and motility through the modulation of myosin-IIA function...
  2. doi Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1
    Jun Arii
    Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Nature 467:859-62. 2010
    ..The identification of NMHC-IIA as an HSV-1 entry receptor and the involvement of NM-IIA regulation in HSV-1 infection provide an insight into HSV-1 entry and identify new targets for antiviral drug development...
  3. pmc Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration
    Nicole A Morin
    Department of Surgery, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
    J Exp Med 205:195-205. 2008
    ..Here, we show that nonmuscle myosin heavy chain IIA (MyH9) is recruited to LFA-1 at the uropod of migrating T lymphocytes, and inhibition of the association of MyH9 with LFA-..
  4. doi Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with the progression of IgA nephropathy in Chinese
    Wenrong Cheng
    Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, and Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, People s Republic of China
    Nephrol Dial Transplant 26:2544-9. 2011
    ..A recent genome-wide association study (GWAS) indicated that the MYH9 gene was significantly associated with non-diabetic ESRD in African-Americans and also influenced kidney function ..
  5. doi Identification of three in-frame deletion mutations in MYH9 disorders suggesting an important hot spot for small rearrangements in MYH9 exon 24
    Koji Miyazaki
    Department of Hematology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, 228 8555 Kanagawa, Japan
    Eur J Haematol 83:230-4. 2009
    b>MYH9 disorders include hereditary macrothrombocytopenias with leukocyte inclusion bodies...
  6. pmc Glomerular MYH9 expression is reduced by HIV-1
    Thomas Hays
    Mount Sinai School of Medicine, Department of Medicine, New York, New York, USA
    AIDS 26:797-803. 2012
    ..Given that loss of MYH9 function causes a Mendelian renal disease, we hypothesized that renal expression of MYH9 is down-regulated by HIV-1 ..
  7. pmc MicroRNA let-7f inhibits tumor invasion and metastasis by targeting MYH9 in human gastric cancer
    Shuli Liang
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital of Digestive Diseases, Xi an, China
    PLoS ONE 6:e18409. 2011
    ..In this study, we investigate whether let-7f acts as a tumor suppressor to inhibit invasion and metastasis in gastric cancers...
  8. doi Patients with Epstein-Fechtner syndromes owing to MYH9 R702 mutations develop progressive proteinuric renal disease
    Takashi Sekine
    Faculty of Medicine, Department of Pediatrics, The University of Tokyo, Tokyo, Japan
    Kidney Int 78:207-14. 2010
    ..underlie rare autosomal dominant diseases such as May-Hegglin anomaly, and Sebastian, Epstein (EPS), and Fechtner (FTNS) syndromes that are characterized by macrothrombocytopenia and cytoplasmic inclusion bodies in granulocytes...
  9. ncbi Myosin IIA regulates cell motility and actomyosin-microtubule crosstalk
    Sharona Even-Ram
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research NIDCR, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Cell Biol 9:299-309. 2007
    ..We conclude that myosin IIA negatively regulates cell migration and suggest that it maintains a balance between the actomyosin and microtubule systems by regulating microtubule dynamics...
  10. pmc Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis
    C P Lin
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Genes Immun 13:232-8. 2012
    ..Multiple studies reported associations between renal diseases and variants in the non-muscle myosin heavy chain 9 (MYH9) and the neighboring apolipoprotein L 1 (APOL1) genes...
  11. doi MYH9-siRNA and MYH9 mutant alleles: expression in cultured cell lines and their effects upon cell structure and function
    Yan Li
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, New York 10016, USA
    Cell Motil Cytoskeleton 65:393-405. 2008
    b>MYH9 encodes a class II nonmuscle myosin heavy chain-A (NMHC-IIA), a widely expressed 1960 amino acid polypeptide, with translated molecular weight of 220 kDa...
  12. doi In vitro expression and characterization of MYH9 mutant alleles linked to hereditary hearing loss
    Calvin C Wei
    Department of Otolaryngology, New York University School of Medicine, New York, NY 10016, USA
    Otolaryngol Head Neck Surg 142:699-703. 2010
    To assess whether MYH9 mutant alleles linked to hereditary hearing loss induce disruption of cellular functions and associated phenotype following transient expression within cultured human cell lines.
  13. pmc Polymorphisms in the non-muscle myosin heavy chain gene (MYH9) are associated with lower glomerular filtration rate in mixed ancestry diabetic subjects from South Africa
    Tandi Edith Matsha
    Department of Biomedical Sciences, Faculty of Health and Wellness Science, Cape Peninsula University of Technology, Cape Town, South Africa
    PLoS ONE 7:e52529. 2012
    Though single nucleotide polymorphisms (SNPs) in the non-muscle myosin gene (MYH9) have been reported to explain most of the excess risk of nondiabetic chronic kidney disease (CKD), in African-Americans, some studies have also shown ..
  14. doi Heavy chain myosin 9-related disease (MYH9 -RD): neutrophil inclusions of myosin-9 as a pathognomonic sign of the disorder
    Anna Savoia
    Medical Genetics, Department of Reproductive and Developmental Sciences, IRCCS Burlo Garofolo, University of Trieste, Trieste, Italy
    Thromb Haemost 103:826-32. 2010
    b>MYH9-related disease ( MYH9-RD) is an autosomal dominant thrombocytopenia with giant platelets variably associated with young-adult onset of progressive sensorineural hearing loss, presenile cataract, and renal damage...
  15. doi Nonmuscle myosin IIA is required for lamellipodia formation through binding to WAVE2 and phosphatidylinositol 3,4,5-triphosphate
    Shigeru Morimura
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama 241 0815, Japan
    Biochem Biophys Res Commun 404:834-40. 2011
    ..We identified p250 as nonmuscle myosin IIA heavy chain (MYH9) by mass spectrometry and immunoblot analysis using anti-MYH9 antibody...
  16. pmc Nonmuscle myosin heavy chain IIA mutations define a spectrum of autosomal dominant macrothrombocytopenias: May-Hegglin anomaly and Fechtner, Sebastian, Epstein, and Alport-like syndromes
    K E Heath
    Department of Human Genetics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Hum Genet 69:1033-45. 2001
    ..mutations, K371N and R702H, as well as the recently identified MYH9 mutation, R705H, which results in DFNA17, were modeled on the basis of X-ray crystallographic data...
  17. pmc Myosin-IIA heavy-chain phosphorylation regulates the motility of MDA-MB-231 carcinoma cells
    Natalya G Dulyaninova
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Biol Cell 18:3144-55. 2007
    ..In contrast, cells expressing the S1943A mutant exhibited reduced migration and lamellipod extension. These observations support a direct role for myosin-IIA heavy-chain phosphorylation in mediating motility and chemotaxis...
  18. doi The spectrum of MYH9-associated nephropathy
    Meredith A Bostrom
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Clin J Am Soc Nephrol 5:1107-13. 2010
    ..Recently, polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) have been associated with nondiabetic kidney diseases in African- and European-derived populations...
  19. pmc Conditional expression of a truncated fragment of nonmuscle myosin II-A alters cell shape but not cytokinesis in HeLa cells
    Q Wei
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Biol Cell 11:3617-27. 2000
    ....
  20. pmc Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells
    Richard K Tsai
    Biophysical Engineering Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 180:989-1003. 2008
    ..A point mutation turns off this motor's contribution to phagocytosis, suggesting that self-recognition inhibits contractile engulfment...
  21. pmc MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis
    Jeffrey B Kopp
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 40:1175-84. 2008
    ..2 and a peak lod of 12.4 centered on MYH9, a functional candidate gene expressed in kidney podocytes...
  22. pmc MYH9 is associated with nondiabetic end-stage renal disease in African Americans
    W H Linda Kao
    Department of Epidemiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Nat Genet 40:1185-92. 2008
    ..2 to 0.6) in the gene encoding nonmuscle myosin heavy chain type II isoform A (MYH9) were associated with two to four times greater risk of nondiabetic ESRD and accounted for a large proportion of ..
  23. pmc Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans
    Jessica N Cooke
    Program in Molecular Medicine and Translational Science, Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 27:1505-11. 2012
    Polymorphisms in the non-muscle myosin IIA gene (MYH9) are associated with focal segmental glomerulosclerosis (FSGS) and non-diabetic end-stage renal disease (ESRD) in African Americans and FSGS in European Americans...
  24. pmc Multiple regulatory steps control mammalian nonmuscle myosin II assembly in live cells
    Mark T Breckenridge
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Mol Biol Cell 20:338-47. 2009
    ..This work furthermore offers cellular insights that help explain platelet and leukocyte defects associated with R1933-stop alleles of patients afflicted with human MYH9-related disorder.
  25. pmc Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15
    George W Nelson
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    Hum Mol Genet 19:1805-15. 2010
    Admixture mapping recently identified MYH9 as a susceptibility gene for idiopathic focal segmental glomerulosclerosis (FSGS), HIV-associated nephropathy (HIVAN) and end-stage kidney disease attributed to hypertension (H-ESKD) in African ..
  26. ncbi Immunofluorescence analysis of neutrophil nonmuscle myosin heavy chain-A in MYH9 disorders: association of subcellular localization with MYH9 mutations
    Shinji Kunishima
    Japanese Red Cross Aichi Blood Center, Seto, Japan
    Lab Invest 83:115-22. 2003
    ..disorders are caused by mutations in the same gene, the MYH9, which encodes the nonmuscle myosin heavy chain-A (NMMHCA)...
  27. pmc The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA
    Hum Genet 127:295-301. 2010
    ..Recent research has identified associations of polymorphisms in the myosin heavy chain type II isoform A (MYH9) gene with hypertensive CKD in African-Americans...
  28. pmc The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans
    Barry I Freedman
    Section on Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Nephrol 32:66-72. 2010
    ..Since MYH9 underlies approximately 40% of end-stage renal disease (ESRD) in AA, we tested for genetic association with LN.
  29. ncbi Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May-Hegglin anomaly
    M J Kelley
    Department of Medicine, Duke University, Durham, North Carolina, USA
    Nat Genet 26:106-8. 2000
    ..Here we screen a candidate gene in this region, encoding non-muscle myosin heavy chain A (MYH9), for mutations in ten families...
  30. ncbi Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes
    M Simons
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    Circ Res 69:530-9. 1991
    ..Comparison of this sequence to cDNA clones encoding the amino-terminal one third of the NMMHC-B sequence (amino acids 58-718) shows them to be 89% identical at the amino acid level and 74% identical at the nucleotide level...
  31. doi Nonmuscle myosin IIA is associated with poor prognosis of esophageal squamous cancer
    Z K Xia
    Department of Cardio Thoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, China
    Dis Esophagus 25:427-36. 2012
    ..021). In addition, MYH9 SiRNA was transfected into esophageal squamous cancer cell line (KYSE-510) to study the role of myosin IIA in cell ..
  32. pmc MYH9 and APOL1 are both associated with sickle cell disease nephropathy
    Allison E Ashley-Koch
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA allison ashleykoch duke edu
    Br J Haematol 155:386-94. 2011
    ..The myosin, heavy chain 9, non-muscle (MYH9) and apolipoprotein L1 (APOL1) genes have been associated with risk for focal segmental glomerulosclerosis and end-..
  33. pmc Two functional S100A4 monomers are necessary for regulating nonmuscle myosin-IIA and HCT116 cell invasion
    Reniqua P House
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States
    Biochemistry 50:6920-32. 2011
    ....
  34. pmc Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African Americans
    Barry I Freedman
    Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    PLoS Genet 7:e1002150. 2011
    Single nucleotide polymorphisms (SNPs) in MYH9 and APOL1 on chromosome 22 (c22) are powerfully associated with non-diabetic end-stage renal disease (ESRD) in African Americans (AAs)...
  35. ncbi Differential localization of myosin-II isozymes in human cultured cells and blood cells
    P Maupin
    Department of Cell Biology and Anatomy, Johns Hopkins Medical School, Baltimore, MD 21205 2196
    J Cell Sci 107:3077-90. 1994
    ..The superimposition of these small spots concentrated in the cleavage furrow produces the intense, uniform staining observed in conventional micrographs of whole cells...
  36. pmc The MYH9/APOL1 region and chronic kidney disease in European-Americans
    Conall M O'Seaghdha
    National Heart, Lung and Blood Institute s Framingham Heart Study and Center for Population Studies, Framingham, MA, USA
    Hum Mol Genet 20:2450-6. 2011
    Polymorphisms in the MYH9 and adjacent APOL1 gene region demonstrate a strong association with non-diabetic kidney disease in African-Americans...
  37. ncbi Regulation of myosin-IIA assembly and Mts1 binding by heavy chain phosphorylation
    Natalya G Dulyaninova
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 44:6867-76. 2005
    ....
  38. ncbi Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration
    Joshua C Sandquist
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 281:35873-83. 2006
    ..Our data suggest that the myosin IIA and IIB isoforms are regulated by different signaling pathways to perform distinct cellular activities and that myosin IIA is preferentially required for Rho-mediated contractile functions...
  39. doi Renal manifestations of patients with MYH9-related disorders
    Kyoung Hee Han
    Department of Pediatrics, Seoul National University Children s Hospital, 101 Daehang no, Jongno gu, Seoul, 110 744, South Korea
    Pediatr Nephrol 26:549-55. 2011
    b>MYH9-related disorders are a group of autosomal, dominantly inherited disorders caused by mutations of the MYH9 gene, which encodes the non-muscle myosin heavy chain IIA (NMMHC-IIA)...
  40. pmc Mechanism of the Ca²+-dependent interaction between S100A4 and tail fragments of nonmuscle myosin heavy chain IIA
    Sandip K Badyal
    Department of Biochemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, UK
    J Mol Biol 405:1004-26. 2011
    ....
  41. pmc A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9
    Giulio Genovese
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 78:698-704. 2010
    Genetic variation at the MYH9 locus is linked to the high incidence of focal segmental glomerulosclerosis (FSGS) and non-diabetic end-stage renal disease among African Americans...
  42. pmc Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene
    Shay Tzur
    Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Hum Genet 128:345-50. 2010
    b>MYH9 has been proposed as a major genetic risk locus for a spectrum of nondiabetic end stage kidney disease (ESKD)...
  43. ncbi Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related disease
    Alessandro Pecci
    Department of Internal Medicine, University of Pavia and Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Policlinico San Matteo Foundation, Pavia, Italy
    Hum Mutat 29:409-17. 2008
    b>MYH9-related disease (MYH9-RD) is a rare autosomal-dominant disorder caused by mutations in MYH9, the gene for the heavy chain of nonmuscle myosin IIA (NMMHC-IIA)...
  44. ncbi Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes. The May-Heggllin/Fechtner Syndrome Consortium
    M Seri
    Laboratory of Molecular Genetics, Institute G Gaslini, Genoa, Italy
    Nat Genet 26:103-5. 2000
    ..Among the identified candidate genes is the gene encoding nonmuscle myosin heavy chain 9 (MYH9; refs 8-10), which is expressed in platelets and upregulated during granulocyte differentiation...
  45. ncbi Expression of the nonmuscle myosin heavy chain IIA in the human kidney and screening for MYH9 mutations in Epstein and Fechtner syndromes
    Christelle Arrondel
    INSERM U 423, Universite Rene Descartes, Hopital Necker Enfants Malades, Paris, France
    J Am Soc Nephrol 13:65-74. 2002
    Mutations in the MYH9 gene, which encodes the nonmuscle myosin heavy chain IIA, have been recently reported in three syndromes that share the association of macrothrombocytopenia (MTCP) and leukocyte inclusions: the May-Hegglin anomaly ..
  46. pmc Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans
    Barry I Freedman
    Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 75:736-45. 2009
    ..association with idiopathic and HIV-related focal segmental glomerulosclerosis and non-muscle myosin heavy chain 9 (MYH9) gene polymorphisms in this ethnic group, we tested for MYH9 associations in a variety of kidney diseases...
  47. pmc Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin
    R L Shoeman
    Max Planck Institut für Zellbiologie, Ladenburg, Federal Republic of Germany
    Am J Pathol 142:221-30. 1993
    ..Nonmuscle myosin heavy chains were also cleaved by this enzyme in vitro. These data demonstrate that this protease can cause alterations in muscle cell ultrastructure in vitro that may be of clinical relevance in infected individuals...
  48. ncbi Cloning of the murine non-muscle myosin heavy chain IIA gene ortholog of human MYH9 responsible for May-Hegglin, Sebastian, Fechtner, and Epstein syndromes
    Maria D'Apolito
    Servizio di Genetica Medica, IRCCS Ospedale CSS, I 71013 San Giovanni Rotondo, Foggia, Italy
    Gene 286:215-22. 2002
    Mutations in the non-muscle myosin heavy chain IIA gene (MYH9) are responsible for May-Hegglin anomaly, Sebastian, Fechtner and Epstein syndromes...
  49. ncbi A single class II myosin modulates T cell motility and stopping, but not synapse formation
    Jordan Jacobelli
    Department of Pathology, University of California at San Francisco, 513 Parnassus Ave, San Francisco, California 93143, USA
    Nat Immunol 5:531-8. 2004
    ..Here we show that nonmuscle myosin heavy chain IIA, or MyH9, is the only class II myosin expressed in T cells and is associated with the uropod during crawling...
  50. pmc Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD
    Barry I Freedman
    1Internal Medicine Nephrology, 2Biochemistry, 3Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 24:3366-71. 2009
    Although MYH9 is strongly associated with biopsy-proven idiopathic and HIV-associated focal segmental glomerulosclerosis (FSGS) and clinically diagnosed 'hypertension-associated' end-stage renal disease (ESRD) in African Americans, its ..
  51. ncbi Myosin is an in vivo substrate of the protein tyrosine phosphatase (SHP-1) after mIgM cross-linking
    Takeshi Baba
    Research Institute for Biological Sciences, Tokyo University of Science, 2669 Yamazaki, Noda, 278 0022, Chiba, Japan
    Biochem Biophys Res Commun 304:67-72. 2003
    ..Thus, myosin is a direct SHP-1 substrate in B cells. The results suggest that SHP-1 plays a critical role in the reorganization of cytoskeletal architecture mediated via BCR stimulation...
  52. pmc Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with albuminuria in hypertensive African Americans: the HyperGEN study
    Barry I Freedman
    Section on Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Nephrol 29:626-32. 2009
    b>MYH9 is a podocyte-expressed gene encoding nonmuscle myosin IIA that is associated with idiopathic and human immunodeficiency virus-associated focal segmental glomerulosclerosis (FSGS) and hypertensive end-stage renal disease in African ..
  53. pmc Genetics of focal segmental glomerulosclerosis and human immunodeficiency virus-associated collapsing glomerulopathy: the role of MYH9 genetic variation
    Cheryl A Winkler
    Scientific Applications International Corporation Frederick, Inc, Laboratory of Genomic Diversity, Center for Cancer Research, National Cancer Institute Frederick, National Institutes of Health, Frederick, MD, USA
    Semin Nephrol 30:111-25. 2010
    ..Admixture mapping identified genetic variants in the nonmuscle myosin heavy chain 9 gene (MYH9) as having a major influence on both FSGS and human immunodeficiency virus-associated collapsing glomerulopathy, ..
  54. ncbi Non-muscle myosin heavy chain IIA and IIB interact and co-localize in living cells: relevance for MYH9-related disease
    Monica Marini
    Laboratory of Molecular Genetics, G Gaslini Institute, 16147 Genova, Italy
    Int J Mol Med 17:729-36. 2006
    ..This argument is relevant not only to cell physiology, but also to human pathology since mutations of the MYH9 gene encoding non-muscle myosin heavy chain II A (NMMHC-A) cause MYH9-related disease (MYH9-RD), an autosomal ..
  55. doi Genome-wide linkage analysis of serum creatinine in three isolated European populations
    Cristian Pattaro
    Institute of Genetic Medicine, European Academy Bozen Bolzano EURAC, Bolzano, Italy
    Kidney Int 76:297-306. 2009
    ..and hypertension, was detected over a region containing the non-muscle myosin heavy chain type II isoform A (MYH9) gene (LOD score=3.52)...
  56. ncbi Effect of Mts1 on the structure and activity of nonmuscle myosin II
    H L Ford
    Department of Biochemistry and Cancer Center, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Biochemistry 36:16321-7. 1997
    ..The data demonstrate an effect of Mts1 on both myosin structure and function, and suggest a route through which Mts1 affects motility as well as metastasis...
  57. ncbi Interaction of metastasis-inducing S100A4 protein in vivo by fluorescence lifetime imaging microscopy
    Shu Zhang
    Cancer and Polio Research Fund Laboratories, School of Biological Sciences, University of Liverpool, Liverpool, L69 7ZB, UK
    Eur Biophys J 34:19-27. 2005
    ....
  58. pmc Worldwide distribution of the MYH9 kidney disease susceptibility alleles and haplotypes: evidence of historical selection in Africa
    Taras K Oleksyk
    Department of Biology, University of Puerto Rico at Mayaguez, Mayaguez, Puerto Rico
    PLoS ONE 5:e11474. 2010
    b>MYH9 was recently identified as renal susceptibility gene (OR 3-8, p < 10(-8)) for major forms of kidney disease disproportionately affecting individuals of African descent...
  59. doi Differential expression of wild-type and mutant NMMHC-IIA polypeptides in blood cells suggests cell-specific regulation mechanisms in MYH9 disorders
    Shinji Kunishima
    Department of Hemostasis and Thrombosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    Blood 111:3015-23. 2008
    b>MYH9 disorders such as May-Hegglin anomaly are characterized by macrothrombocytopenia and cytoplasmic granulocyte inclusion bodies that result from mutations in MYH9, the gene for nonmuscle myosin heavy chain-IIA (NMMHC-IIA)...
  60. doi Identification and characterization of the first large deletion of the MYH9 gene associated with MYH9 disorders
    Shinji Kunishima
    Department of Hemostasis and Thrombosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    Eur J Haematol 80:540-4. 2008
    b>MYH9 disorders are autosomal dominant macrothrombocytopenias with leukocyte inclusion bodies. Single point mutations in the protein-coding sequence of the MYH9 gene are the most common cause...
  61. ncbi Application of a diagnostic algorithm for inherited thrombocytopenias to 46 consecutive patients
    Patrizia Noris
    Department of Internal Medicine, IRCCS Policlinico San Matteo University of Pavia, Italy
    Haematologica 89:1219-25. 2004
    ..The aim of the present study was to validate this diagnostic algorithm by applying it to a case series of genetic thrombocytopenias...
  62. doi Identification of the first duplication in MYH9-related disease: a hot spot for unequal crossing-over within exon 24 of the MYH9 gene
    Daniela De Rocco
    Medical Genetics, Department of Reproductive and Developmental Sciences, Institute for Maternal and Child Health IRCCS Burlo Garofolo, University of Trieste, Via dell Istria 65 1, 34137 Trieste, Italy
    Eur J Med Genet 52:191-4. 2009
    b>MYH9-related disease (MYH9RD) is a rare autosomal dominant disorder caused by mutations in MYH9, the gene encoding the heavy chain of non-muscle myosin IIA...
  63. pmc Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion
    Brian A Babbin
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    Am J Pathol 174:436-48. 2009
    ..These observations indicate multiple functions for NM IIA, which, along with the regulation of the F-actin cytoskeleton and cell-matrix adhesions, involve previously unrecognized control of intracellular signaling and protein expression...
  64. pmc Gene-gene and gene-environment interactions in HIV-associated nephropathy: A focus on the MYH9 nephropathy susceptibility gene
    Marina Nunez
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Adv Chronic Kidney Dis 17:44-51. 2010
    ..Although polymorphisms in the MYH9 gene on chromosome 22 are strongly associated with HIVAN, as well as with idiopathic focal segmental ..
  65. ncbi MYH9-related disease: May-Hegglin anomaly, Sebastian syndrome, Fechtner syndrome, and Epstein syndrome are not distinct entities but represent a variable expression of a single illness
    Marco Seri
    Laboratorio di Genetica Molecolare, Istituto G Gaslini, Genova, Italy
    Medicine (Baltimore) 82:203-15. 2003
    ..Mutations in the MYH9 gene encoding for the nonmuscle myosin heavy chain IIA (NMMHC-IIA) have been identified in all these syndromes...
  66. pmc African ancestry allelic variation at the MYH9 gene contributes to increased susceptibility to non-diabetic end-stage kidney disease in Hispanic Americans
    Doron M Behar
    Molecular Medicine Laboratory, Rambam Health Care Campus, Haifa 31096, Israel
    Hum Mol Genet 19:1816-27. 2010
    Recent studies identified MYH9 as a major susceptibility gene for common forms of non-diabetic end-stage kidney disease (ESKD)...
  67. ncbi Identification of six novel MYH9 mutations and genotype-phenotype relationships in autosomal dominant macrothrombocytopenia with leukocyte inclusions
    S Kunishima
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    J Hum Genet 46:722-9. 2001
    ..with leukocyte inclusions, May-Hegglin anomaly (MHA), Sebastian syndrome (SBS), and Fechtner syndrome (FTNS), are rare platelet disorders characterized by a triad of giant platelets, thrombocytopenia, and characteristic Dö..
  68. doi Identification of the first in cis mutations in MYH9 disorder
    Yuji Miyajima
    Department of Pediatrics, Anjo Kosei Hospital, Anjo, Aichi, Japan
    Eur J Haematol 82:288-91. 2009
    Here, we report the first in cis mutations in exon 1 of the MYH9 gene in a patient with MYH9 disorder. The patient was a 5-yr-old girl with macrothrombocytopenia and conspicuous cytoplasmic inclusion bodies in neutrophils...
  69. ncbi Vertebrate nonmuscle myosin II isoforms rescue small interfering RNA-induced defects in COS-7 cell cytokinesis
    Jianjun Bao
    Laboratory of Molecular Cardiology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:19594-9. 2005
    ....
  70. ncbi Immunocytochemistry for the heavy chain of the non-muscle myosin IIA as a diagnostic tool for MYH9-related disorders
    Alessandro Pecci
    Department of Internal Medicine, IRCCS San Matteo, University of Pavia, Italy
    Br J Haematol 117:164-7. 2002
    ..We investigated the NMMHC-A localization in blood cells from eight MHA, SBS or FTNS patients with known MYH9 mutations...
  71. ncbi Pathogenetic mechanisms of hematological abnormalities of patients with MYH9 mutations
    Alessandro Pecci
    Department of Internal Medicine, University of Pavia, Italy
    Hum Mol Genet 14:3169-78. 2005
    Mutations of MYH9, the gene for non-muscle myosin heavy chain IIA (NMMHC-IIA), cause a complex clinical phenotype characterized by macrothrombocytopenia and granulocyte inclusion bodies, often associated with deafness, cataracts and/or ..
  72. ncbi Induction of nonmuscle myosin heavy chain II-C by butyrate in RAW 264.7 mouse macrophages
    Denis B Buxton
    Laboratory of Molecular Cardiology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:15449-55. 2003
    ..8-Bromo-cGMP had no effect on nonmuscle myosin heavy chain induction, consistent with a cGMP-independent mechanism for nitric oxide-mediated inhibition of nonmuscle myosin heavy chain II-C induction...
  73. ncbi Increased expression of non-muscle myosin heavy chain-B in connective tissue cells of hypertrophic rat urinary bladder
    R Sjuve
    Department of Physiological Sciences, Lund University, Sweden
    Cell Tissue Res 304:271-8. 2001
    ..The NM-MHC-B-positive cells could have a role in the production of extracellular matrix and growth factors or be involved in modulation of spontaneous contractile activity...
  74. ncbi Ablation and mutation of nonmuscle myosin heavy chain II-B results in a defect in cardiac myocyte cytokinesis
    Kazuyo Takeda
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1762, USA
    Circ Res 93:330-7. 2003
    ..Whereas cardiac myocytes completely ablated for NMHC II-B show enlargement and binucleation, mice expressing as little as 6% of the normal amount of wild-type NMHC II-B in the heart do not show these abnormalities...
  75. ncbi Expression of non-muscle myosin heavy chain in rat heart after immunosuppressive treatment
    Rita Rezzani
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnologies, University of Brescia, V le Europa 11, 25123, Brescia, Italy
    Int Immunopharmacol 6:962-7. 2006
    ..This could be explained as a tentative of cardiac tissue to maintain the structural integrity of intercalated disks and so the contraction/relaxation process...
  76. ncbi Transforming growth factor-beta1 regulates cell growth and causes downregulation of SMemb/non-muscle myosin heavy chain B mRNA in human prostate stromal cells
    Kenji Obara
    Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Scand J Urol Nephrol 39:366-71. 2005
    ..The expression of the SM2 isoform of smooth muscle myosin heavy chain (SMMHC) mRNA was also examined...
  77. ncbi IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression during phorbol ester-induced promyelocytic HL-60 differentiation
    Myung Chul Chung
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute NIH, 10 Center Drive, Bethesda, MD 20892, USA
    J Biol Chem 279:56042-52. 2004
    ..Together, these results indicate that IRF-2 contributes to transcriptional activation of the NMHC-A gene via 32kb-150 during TPA-induced differentiation of HL-60 cells...
  78. ncbi Differential expression of non-muscle myosin heavy chain genes during Xenopus embryogenesis
    N Bhatia-Dey
    Laboratory of Molecular Cardiology, National Heart Lung and Blood Institute, Bethesda, MD, USA
    Mech Dev 78:33-6. 1998
    ....
  79. ncbi Minor histocompatibility antigen-specific cytotoxic T lymphocytes generated with dendritic cells from DLA-identical littermates
    George E Georges
    Department of Medicine, University of Washington, Seattle, Washington 98109 1024, USA
    Biol Blood Marrow Transplant 9:234-42. 2003
    Donor cytotoxic T lymphocytes (CTL) specific for minor histocompatibility antigens (mHA) mediate the graft-versus-host effect whereas host mHA-specific CTL mediate graft rejection in the setting of major histocompatibility complex ..
  80. pmc MYH9 genetic variants associated with glomerular disease: what is the role for genetic testing?
    Jeffrey B Kopp
    Kidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1268, USA
    Semin Nephrol 30:409-17. 2010
    Genetic variation in MYH9, encoding nonmuscle myosin IIA heavy chain, has been associated recently with increased risk for kidney disease...
  81. pmc The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway
    Zhao Chen
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    Blood 110:171-9. 2007
    The gene implicated in the May-Hegglin anomaly and related macrothrombocytopenias, MYH9, encodes myosin-IIA, a protein that enables morphogenesis in diverse cell types...
  82. ncbi Cloning and developmental expression of nonmuscle myosin IIA (Myh9) in the mammalian inner ear
    Anand N Mhatre
    Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
    J Neurosci Res 76:296-305. 2004
    b>MYH9 encoding a nonmuscle myosin heavy chain has been linked to nonsyndromic and syndromic forms of autosomal dominant hereditary hearing loss, suggesting a critical biological role of this motor protein in the auditory organ...
  83. ncbi [A non-familial May-Hegglin anomaly accompanying with MYH9 gene R1933X mutation and I1626V polymorphism]
    Ying Li
    Department of Hematology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhonghua Xue Ye Xue Za Zhi 30:577-81. 2009
    To identify the nonmuscle myosin heavy chain 9 (MYH9) gene mutation site in a May-Hegglin anomaly(MHA) patient, and to analyze the genotype of her relatives to exclude the inherit correlation between the proband and her family members.
  84. ncbi A notable case report of May-Hegglin anomaly with immune complex-related nephropathy: a genetic and histological analysis
    Y Ohtsuka
    Department of Pediatrics, Faculty of Medicine, Saga University, Saga City, Japan
    Clin Nephrol 75:255-62. 2011
    ..Mutations in the MYH9 gene, encoding non-muscle myosin heavy chain IIA (NMMHC-IIA) have been identified in patients with MHA and other ..
  85. ncbi [Usefulness of immunofluorescence analysis of neutrophil nonmuscle myosin heavy chain-A for diagnosing in two sisters with May-Hegglin anomaly]
    Noriko Kimura
    Department of Laboratory Medicine, Nara City Hospital, Japan
    Rinsho Ketsueki 49:1614-8. 2008
    ..MHA is caused by mutations in the MYH9 gene, which encodes the nonmuscle mysosin heavy chain-A (NMMCH-A)...
  86. ncbi Kappa immunoglobulin light chain polymorphisms and survival after allogeneic transplantation for B-cell malignancies: a potential graft-vs-leukaemia target
    T L Etto
    Bone Marrow Transplant Programme, Alfred Hospital, Melbourne, Australia
    Tissue Antigens 69:56-61. 2007
    ..antigen (HLA)-matched haematopoietic stem cell transplantation (HSCT) setting, minor histocompatibility antigen (mHA) disparities between recipient and donor can lead to graft-vs-host disease (GVHD) or graft rejection...
  87. doi Plasma from a case of recurrent idiopathic FSGS perturbs non-muscle myosin IIA (MYH9 protein) in human podocytes
    Sima Babayeva
    Department of Medicine, McGill University, 3775 University Street, Montreal, QC, H3A2B4, Canada
    Pediatr Nephrol 26:1071-81. 2011
    The MYH9 gene encodes a non-muscle myosin IIA heavy chain (NMMHC-IIA) expressed in podocytes...
  88. ncbi Expression of Myh9 in the mammalian cochlea: localization within the stereocilia
    Anand N Mhatre
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci Res 84:809-18. 2006
    Mutations of non-muscle myosin Type IIA or MYH9 are linked to syndromic or nonsyndromic hearing loss. The biologic function of MYH9 in the auditory organ and the pathophysiology of its dysfunction remain to be determined...
  89. pmc Regulated proteolysis of nonmuscle myosin IIA stimulates osteoclast fusion
    Brooke K McMichael
    Department of Physiology and Cell Biology, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    J Biol Chem 284:12266-75. 2009
    The nonmuscle myosin IIA heavy chain (Myh9) is strongly associated with adhesion structures of osteoclasts...
  90. ncbi Menière's disease as a late manifestation of congenital syphilis
    F Indesteege
    ENT Department, Middelheim General Hospital, Antwerp, Belgium
    Acta Otorhinolaryngol Belg 43:327-33. 1989
    ..The value of a positive serological test (FTA - ABS or MHA - T.P.) in the presence of inner-ear symptoms is discussed.
  91. pmc Evaluation of an enzyme immunoassay technique for detection of antibodies against Treponema pallidum
    Rita Castro
    Unidade de Doenças Sexualmente Transmitidas, Centro de Malaria e Outras Doencas Tropicais, Instituto de Higiene e Medicina Tropical, Lisbon, Portugal
    J Clin Microbiol 41:250-3. 2003
    ..were 100 and 93%, respectively, compared with the results of a microhemagglutination assay for Treponema pallidum (MHA-TP) and 99...
  92. pmc Of mice and men: Relevance of cellular and molecular characterizations of myosin IIA to MYH9-related human disease
    Sharona Even-Ram
    The Stem Cell Center, Goldyn Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    Cell Adh Migr 1:152-5. 2007
    ..In humans, various mutations in the MYH9 gene that encodes the myosin IIA heavy chain cause autosomal dominant disease, whereas in mice, the complete ..
  93. ncbi Use of a novel serum ELISA method and the tonsil-carrier state for evaluation of Mycoplasma hyosynoviae distributions in pig herds with or without clinical arthritis
    Elisabeth Okholm Nielsen
    The National Committee for Pig Production, Danish Bacon and Meat Council, Axeltorv 3, 1609 Copenhagen V, Denmark
    Vet Microbiol 111:41-50. 2005
    ..hyosynoviae arthritis (MhA herds, n = 4) and in herds with M...
  94. ncbi Floccular modulation of vestibuloocular pathways and cerebellum-related plasticity: An in vitro whole brain study
    A L Babalian
    Laboratoire de la Neurobiologie des Réseaux Sensorimoteures, Centre National de la Recherche Scientifique, 75270 Paris Cedex 06, France
    J Neurophysiol 84:2514-28. 2000
    ..responses in abducens and oculomotor nerves and abducens nucleus; for identification of flocculus target neurons (FTNs) in the vestibular nuclei and intracellular study of some of their physiological properties; to search for possible ..
  95. doi MYH9 related disease: four novel mutations of the tail domain of myosin-9 correlating with a mild clinical phenotype
    Alessandro Pecci
    Department of Internal Medicine, University of Pavia and IRCCS Policlinico San Matteo Foundation, Pavia
    Eur J Haematol 84:291-7. 2010
    b>MYH9-related disease (MYH9-RD) is a rare autosomal dominant disorder caused by mutations in MYH9, the gene encoding the heavy chain of non-muscle myosin IIA...
  96. ncbi [Expression and function of non-muscle myosin-IIA in Fechtner syndrome]
    Hai yan Yang
    Ministry of Health, Jiangsu Institute of Hematology, The First Hospital of Suzhou University, Suzhou 215006, Jiagnsu Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:871-4. 2008
    ..IIA and IIB show obvious interaction, IIB partly compensates the IIA defect derived from MYH9 mutations, and may delay or prevent the development of clinically relevant abnormalities.
  97. ncbi [Performance of different methods of oxacillin resistance detection in atypic strains of Staphylococcus aureus]
    F Hamdad
    Service de Bacteriologie Hygiene, CHU d Amiens, France
    Pathol Biol (Paris) 54:447-52. 2006
    ..The diffusion method using the 5 microg oxacillin and 30 microg cefoxitin discs on Mueller-Hinton Agar (MHA) with and without NaCl, the incubation at 35 degrees C or 30 degrees C for 24 or 48 hours respectively, and the ..
  98. ncbi On-column derivatization-capillary electrochromatography with o-phthalaldehyde/alkylthiol for assay of biogenic amines
    Shigeyuki Oguri
    Laboratory of Food Science, Department of Home Economics, Aichi Gakusen University, 28 Kamikawanari, Hegoshi cho, Okazaki City 444 8520, Japan
    J Chromatogr A 1044:271-6. 2004
    The elution behaviors of the biogenic amines, histamine (HA) and its metabolite methyl histamine (MHA), were evaluated by means of on-column derivatization (OCD)-capillary electrochromatography (CEC) which employed a monolithic ..
  99. ncbi Cerebrospinal fluid treponemal antibodies in untreated early syphilis
    C M Marra
    Department of Medicine, University of Washington, Seattle
    Arch Neurol 52:68-72. 1995
    ..cell count, protein, VDRL test, and antibodies to Treponema pallidum by microhemagglutination test for T pallidum (MHA-TP) and fluorescent treponemal antibody absorption test (FTA-ABS); albumin ratio; and IgG index...
  100. ncbi Prevalence of neurosyphilis in human immunodeficiency virus-infected patients with latent syphilis
    P D Holtom
    Los Angeles County University of Southern California Medical Center 90033
    Am J Med 93:9-12. 1992
    ..with latent syphilis (reactive serum rapid plasma reagin [RPR] and microhemagglutination-Treponema pallidum [MHA-TP])...
  101. ncbi The degradation of haem by carbon tetrachloride: metabolic activation requires a free axial coordination site on the haem iron and electron donation
    M Manno
    Biochemical Pharmacology Section, Toxicology Unit, Medical Research Council Laboratories, Surrey, UK
    Xenobiotica 19:1023-35. 1989
    ..of carbon tetrachloride (CCl4) in vitro has been investigated under anaerobic conditions, using methaemalbumin (MHA) and either sodium dithionite or NADPH together with NADPH-cytochrome P-450 reductase (EC 1.6.2...

Research Grants62

  1. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh A Shivdasani; Fiscal Year: 2012
    ..biological studies, genetic analysis in mice, and appreciation of congenital human thrombocytopenias such as the Myh9- related disorders...
  2. Identifying the earliest events in HIV-1 associated nephropathy via genome-wide
    Ali G Gharavi; Fiscal Year: 2013
    ..complex determination, with significant contribution from genetic variation in the nonmuscle myosin heavy chain 9 (MYH9), a podocyte expressed gene...
  3. RNA profiling of HIV-associated nephropathy in patients with the MYH9 risk allele
    PAUL EVAN KLOTMAN; Fiscal Year: 2010
    ..Recent Genome-wide analyses have identified a strong association of the gene MYH9, which encodes non-muscle myosin heavy chain IIA (Myosin-9), with idiopathic and HIV-associated FSGS in African-..
  4. Characterizing early neural crest phosphoregulation using antiphosphatase targets
    Laura S Gammill; Fiscal Year: 2013
    ..a first step in revealing the mechanism of this requirement, two-hybrid screening identified myosin heavy chain 9 (MYH9) as a candidate phosphorylation-dependent target of Paladin...
  5. Cellular Regulation of Dictyostelium Myosin Heavy Chain Kinases
    Paul A Steimle; Fiscal Year: 2012
    ..turnover can lead to abnormal platelet formation, glomerulonephritis, among other pathologies associated with MYH9-related disorders...
  6. Genetic Determinants of Susceptibility to Kidney Disease in African Americans
    Thomas M Coffman; Fiscal Year: 2010
    ..Recent studies have identified polymorphisms in the gene encoding MYH9, a non-muscle myosin heavy chain that are associated with susceptibility to ESRD in African-Americans, explaining a ..
  7. Actomyosin-Based Podocyte Contractility and Glomerular Pathobiology
    Joel M Henderson; Fiscal Year: 2012
    ..aim will be to develop a transgenic mouse model that fails to express a specific isoform of myosin heavy chain, Myh9, in a podocyte-specific fashion and under temporal control...
  8. The role of autoimmune natural IgM in human myocardial infarction
    Ming Zhang; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE This study will provide important insight of a new mechanism in ischemic myocardial injury, and may identify new markers for myocardial infarction. ..
  9. Genome-wide Identification of Minor Histocompatibility Antigens
    Shoudan Liang; Fiscal Year: 2012
    ..best correlate with long-term remission, using existing and newly developed methods;and (3) experimentally verify mHA-HLA binding by tetramer technique, and verify leukemia-specific lysis by CTL cytotoxicity assay...
  10. Platelet Transfusion Induced Transplant Rejection Across mHA barriers.
    James C Zimring; Fiscal Year: 2013
    ..These studies have the potential to directly benefit patient populations who require platelet transfusions and subsequent BMT. ..
  11. Basic FGF Low Affinity Receptors in HIVAN
    Patricio E Ray; Fiscal Year: 2012
    ..screened for the presence of the HIV-genome, HBGF, HSPG, and genotyped to characterize a genetic variation in the MYH9 gene, encoding the non-muscle myosin IIA heavy chain, that is associated with HIV-collapsing glomerulopathy in ..
  12. A National Consortium to Explore the Genotypic Basis for ESRD in Lupus
    Robert P Kimberly; Fiscal Year: 2010
    ..in SLE-related ESRD suggest that at least two genetic factors, -- certain allelic variants of the genes FCGR3A and MYH9, -- contribute to ESRD risk. However, two genes alone do not define the scope of genetic risk for ESRD...
  13. Leukemia Stem Cell Antigen Discovery Using Advanced Genomic and Proteomic Methods
    PAUL MICHAEL ARMISTEAD; Fiscal Year: 2013
    ..at the computational predication of leukemia stem cell associated minor histocompatibility antigens (LSC-associated mHA). Dr...
  14. The role of complement system in alloimmune responses
    Qing Ma; Fiscal Year: 2013
    ..GVHD), a result of alloimmune responses elicited by donor T lymphocytes to major and minor antigens (mHA). The disease is characterized primarily by targeted epithelial cell injury in skin, intestine and liver...
  15. H3Africa Kidney Disease Research Network
    Akinlolu O Ojo; Fiscal Year: 2013
    ..g., MYH9 and AP0L1) and kidney disease...
  16. Natural History of MYH9-Associated Nephropathy
    BARRY IRA FREEDMAN; Fiscal Year: 2012
    ..This application proposes to determine the natural history of MYH9-associated HN in African Americans, as MYH9 accounts for 70% of all non- diabetic cases of end-stage renal disease (..
  17. Collaborative Model Addressing Mental Health in the Perinatal Period
    Cynthia D Connelly; Fiscal Year: 2012
    ..Utilizing a standardized instrument and a centralized Mental Health Advisor (MHA) to support providers and proactively contact depressed women, early recognition and treatment of MD will benefit ..
  18. Transcriptional Targets of PDGF Signaling during Craniofacial Development
    Harish Vasudevan; Fiscal Year: 2013
    ..In addition, many transcriptional targets of SRF (ActB, FlnA, and MyH9) are implicated in human craniofacial development...
  19. Identification of Minor Histocompatibility Antigens
    David Miklos; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Minor histocompatibility antigens (mHA) are peptides derived from normal cellular proteins that are presented by major histocompatibility antigen (MHC) class I and class H molecules...
  20. Mechanisms of GVHD
    Joseph Antin; Fiscal Year: 2007
    ..data on immune reconstitution, chimerism, lymphocyte adhesion/migration, and minor histocompatibility antigens (mHA) recognition with patient outcomes...
  21. Multiple-Impact Effectiveness of a State Supported Employment Policy Initiative
    David Salkever; Fiscal Year: 2013
    ..the implementation and diffusion of IPS-SE services, undertaken by the Maryland Mental Hygiene Administration (MHA), began as a pilot project in 2002...
  22. Improving Inpatient Psychiatric Payment: Cost and Quality Implications
    DONALD MICHAEL STEINWACHS; Fiscal Year: 2010
    ..the State of Maryland Health Services Cost Review Commission (HSCRC) and Maryland Mental Hygiene Administration (MHA)...
  23. Burden of Chronic Kidney Disease in HIV Infection
    Michelle M Estrella; Fiscal Year: 2013
    ..of kidney function;3) an investigation of the risk of CKD development and progression related to HAART and HIV disease stage;and 4) a validation of the association of MYH9 with CKD progression and specific renal histopathologic findings.
  24. Mechanisms of GVHD
    Joseph H Antin; Fiscal Year: 2013
    ..to HY antigens are important in cGVHD physiology underscores the need to develop more tools to identify somatic mHA as a step toward the integration of mHA and genetic determinates of immune reactivity...
  25. IMPROVING MENTAL HEALTH STATISTICS IN MARYLAND
    TIMOTHY SANTONI; Fiscal Year: 1991
    ..New reporting and system requirements will be prepared, and local agencies will be given MHA consultation and funding to meet these revised, expanded requirements...
  26. IMPROVING MENTAL HEALTH STATISTICS IN MARYLAND
    TIMOTHY SANTONI; Fiscal Year: 1992
    ..New reporting and system requirements will be prepared, and local agencies will be given MHA consultation and funding to meet these revised, expanded requirements...
  27. Maryland Science to Service for Children and Families
    ALBERT ZACHIK; Fiscal Year: 2003
    ..This grant will expand the capacity of the Mental Hygiene Administration (MHA)-sponsored Systems Evaluation Center at the University of Maryland Department of Psychiatry - which is already ..
  28. Role of Conventional Myosin MYH9 in Hearing
    Anil Lalwani; Fiscal Year: 2006
    Through the candidate gene approach, we have identified MYH9 as the causative gene responsible for DFNA17, an autosomal dominant nonsyndromic form of hereditary hearing impairment...
  29. Statewide Efforts to Improve Care in Intensive Care Unit
    Peter Pronovost; Fiscal Year: 2004
    ..To implement these aims, we will develop interventions for MHA who will then interact with Michigan hospitals to implement these interventions...
  30. NIMH/M-RISP: ADVANCING RESEARCH IN PUERTO RICO
    Guillermo Bernal; Fiscal Year: 2007
    ..faculty members in conducting pilot work leading to a competitive research grant on mental health and HIV/AIDS (MHA) problems, especially interventions and outcome research; (2) increasing the participation of graduate and ..
  31. NEUROSYPHILIS AND AIDS--PCR METHOD TO DETECT T. PALLIDUM
    Lionel Resnick; Fiscal Year: 1993
    ..In addition, individuals with HIV infection have been documented to lose their treponemal test reactivity to MHA-TP and FTA-ABS. Therefore, the need for the development of more effective methods to detect T. pallidum exists...
  32. High School COR Research Training for Hispanic
    WANDA RODRIGUEZ AROCHO; Fiscal Year: 2006
    ..of well-trained Hispanics in biomedical and behavioral research careers in the field of mental health and HIV-AIDS (MHA)...
  33. Continuation of the FIND Study
    Barry Freedman; Fiscal Year: 2006
    ..of genes that cause diabetic complications will take us one step closer to finding treatments that may have the potential to slow or prevent the development of these serious complications of diabetes mellitus [unreadable] [unreadable]..
  34. GENETIC ANALYSIS OF HUMAN HYPERTENSIVE ESRD
    Barry Freedman; Fiscal Year: 2001
    ..The identification of hypertension-associated renal failure genes would form a genetic basis for detection of high risk individuals and development of intervention and treatment strategies for prevention of H-ESRD. ..
  35. Micro-Western Blot for Proteomics Studies
    David Wallace; Fiscal Year: 2006
    ..In circumstances where a protein sample is limited or the source of the antibody is rare or expensive, the Micro-Western blot method will provide a powerful alternative to conventional Western blotting methods. [unreadable] [unreadable]..
  36. Improving Platelet Recovery After Radiation
    George Georges; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  37. Immunosupression-Resistant Gene Modified Donor T Cells
    George Georges; Fiscal Year: 2009
    ..Results from these studies have the strong potential to be directly translated to future gene therapy clinical trials. ..
  38. Improving Gastrointestinal Recovery after Radiation
    George Georges; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  39. GENE MODIFIED T-CELLS FOR ENGRAFTMENT AND GVHD CONTROL
    George Georges; Fiscal Year: 2003
    ..We will test if donor CTL specific for host minor histocompatibility antigens can convert mixed to complete donor chimerism. If successful this would make MHC-matched stem cell transplantation less toxic. ..
  40. Cytokines for Immune Protection from Acute Irradiation
    George Georges; Fiscal Year: 2005
    ..The secondary endpoint is immune reconstitution. Upon study completion, we will have identified the optimal cytokine treatment and the highest dose of TBI that can be reliably survived without HSC support. ..
  41. Gene Modified Donor T Cell Infusion into Mixed Chimeras
    George Georges; Fiscal Year: 2003
    ..If successful, this study could translate into improved control of the GVH reaction and improved survival after allogeneic HCT. ..
  42. Measurement of Hypoxia in Non Small Cell Lung Carcinoma
    Michael Kelley; Fiscal Year: 2003
    ..We believe the data from this pilot study will be useful to design future study(ies) with clinical endpoints and to guide selection of subjects for novel hypoxia-directed therapies in patients with NSCLC...
  43. For-Profit Ownership and End-of-Life Care
    Elizabeth Bradley; Fiscal Year: 2009
    ..Relevance in lay language: We will generate knowledge about the influence of for-profit hospice ownership on the experiences of patients with cancer and their families. ..
  44. Transmucosal Intra-Oral Drug Delivery System for THC
    Mahmoud Elsohly; Fiscal Year: 2003
    ..abstract_text> ..
  45. The role of Ach in CD8+ Cytolytic T cell development
    JAMES ZIMRING; Fiscal Year: 2005
    ..abstract_text> ..
  46. Selective depletion of alloreactive T cells in BMT
    JAMES ZIMRING; Fiscal Year: 2005
    ..In keeping with the stated purpose of this RFA, these studies represent the "development and application of cell engineering methods to predictably induce tolerance..." ..
  47. Randomized Trial of Rosiglitazone for Ulcerative Colitis
    James Lewis; Fiscal Year: 2005
    ..If our hypothesis is correct, this study will serve to establish that ligands for PPARg possess biological activity necessary to modulate the inflammatory response in the intact human colon. ..
  48. Compositions for Prevention/Prophylactic Treatment of Poison Ivy Dermatitis
    Mahmoud Elsohly; Fiscal Year: 2006
    ..This proposal addresses a major public health problem, namely contact allergic dermatitis and promises the development of an effective agent to address this problem. [unreadable] [unreadable]..
  49. Association of PPAR gamma ligands & colonic neoplasia
    James Lewis; Fiscal Year: 2006
    ..Our results will allow us to translate the existing in vitro and in vivo observations to the intact human colon and could lead to further chemoprevention strategies. ..
  50. Phase I/II Trial of ZD1839 and Celecoxib in Ex-Smokers
    Michael Kelley; Fiscal Year: 2006
    ..abstract_text> ..
  51. PHYSIOLOGICAL CHEMISTRY OF INTEGRIN FUNCTION
    Michael Dustin; Fiscal Year: 2007
    ..These experiments should provide new insight into regulation of integrin function and identify potential therapeutic targets for regulation of leukocyte integrins. ..
  52. Admixture Mapping to Identify T2DM Genes in African Americans
    Wen Hong Kao; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  53. Alloimmunization to mHAs by RBC Transfusion
    JAMES ZIMRING; Fiscal Year: 2007
    ..provides a mechanism by which chronic transfusion of even stringently leukoreduced RBC may result in sufficient mHA immunization to increase the frequency of BMT rejection...
  54. Identification of Genes for ESRD in African Americans
    Wen Hong Kao; Fiscal Year: 2007
    ..This study will provide key insights into the genetic control of susceptibility of ESRD [unreadable] [unreadable]..
  55. CD8 + CD75s + regulatory T cells in anti-tumor immunity
    JAMES ZIMRING; Fiscal Year: 2007
    ..These aims propose to investigate the role that negative regulatory T cells play in the establishment of immunological tolerance to tumor antigens and the fashion in which their elimination can result in tumor rejection. ..
  56. Appropriate Pneumococcal Vaccination in Infants in Fiji
    Fiona Russell; Fiscal Year: 2007
    ..The results of this study will form the basis of an effectiveness evaluation following the pilot introduction of pneumococcal immunization into Fiji in 3-5 years time. [unreadable] [unreadable]..
  57. Induction of Immunological Tolerance for Gene Therapy
    JAMES ZIMRING; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  58. SURFACE ANTIGENS OF TREPONEMA PALLIDUM
    Wesley Van Voorhis; Fiscal Year: 2008
    ..Finally, these studies will help define the protective immune response that results after immunization with Tp92 as well as the immune response to Tp92 that occurs during infection. [unreadable] [unreadable]..
  59. GENETIC ANALYSIS OF HEREDITARY MACROTHROMBOCYTOPENIAS
    Michael Kelley; Fiscal Year: 2002
    ..clinical syndromes characterized by giant platelets and thrombocytopenia that include May-Hegglin anomaly (MHA), Fechtner syndrome, and Sebastian syndrome...