MYH7

Summary

Gene Symbol: MYH7
Description: myosin, heavy chain 7, cardiac muscle, beta
Alias: CMD1S, CMH1, MPD1, MYHCB, SPMD, SPMM, beta-myosin heavy chain, myHC-beta, myhc-slow, myopathy, distal 1, myosin heavy chain (AA 1-96), myosin heavy chain 7, myosin heavy chain slow isoform, myosin heavy chain, cardiac muscle beta isoform, myosin, heavy polypeptide 7, cardiac muscle, beta, myosin-7, rhabdomyosarcoma antigen MU-RMS-40.7A
Species: human

Top Publications

  1. ncbi Mutation screening in dilated cardiomyopathy: prominent role of the beta myosin heavy chain gene
    Eric Villard
    INSERM Unité 621, IFR14, CIB Pitié Salpêtrière, 91 Bd de l Hopital, 75013 Paris, France
    Eur Heart J 26:794-803. 2005
  2. ncbi A 7.1 kbp beta-myosin heavy chain promoter, efficient for green fluorescent protein expression, probably induces lethality when overexpressing a mutated transforming growth factor-beta type II receptor in transgenic mice
    Severine Allegra
    UMR 369 INSERM UCBL and IFR 62 Laënnec
    Transgenic Res 14:69-80. 2005
  3. ncbi Activation of the beta myosin heavy chain promoter by MEF-2D, MyoD, p300, and the calcineurin/NFATc1 pathway
    Joachim D Meissner
    Department of Physiology, Hannover Medical School, Hannover, Germany
    J Cell Physiol 211:138-48. 2007
  4. ncbi Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy
    Pascale Richard
    UF de Cardiogénétique et Myogénétique, Service de Biochimie B, Hopital de la Salpetriere, 47 Bld de l Hopital, 75651 Paris Cedex 13, France
    Circulation 107:2227-32. 2003
  5. pmc Structural interpretation of the mutations in the beta-cardiac myosin that have been implicated in familial hypertrophic cardiomyopathy
    I Rayment
    Institute for Enzyme Research, Graduate School, University of Wisconsin, Madison 53705 4098, USA
    Proc Natl Acad Sci U S A 92:3864-8. 1995
  6. pmc Molecular cloning and characterization of human cardiac alpha- and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atrium
    M Kurabayashi
    Third Department of Internal Medicine, University of Tokyo, Japan
    J Clin Invest 82:524-31. 1988
  7. ncbi A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation
    A A Geisterfer-Lowrance
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Cell 62:999-1006. 1990
  8. ncbi Mutation in myosin heavy chain 6 causes atrial septal defect
    Yung Hao Ching
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Nat Genet 37:423-8. 2005
  9. ncbi Prevalence of cardiac beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy
    Andreas Perrot
    Kardiologie am Campus Buch und Virchow Klinikum, Charité Universitätsmedizin Berlin und Max Delbrück Centrum für Molekulare Medizin, Wiltbergstrasse 50, 13125 Berlin, Germany
    J Mol Med (Berl) 83:468-77. 2005
  10. ncbi Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy
    M Kamisago
    Cardiovascular Division, Brigham and Women s Hospital, and Harvard Medical School and Howard Hughes Medical Institute, Boston, MA, USA
    N Engl J Med 343:1688-96. 2000

Research Grants

Detail Information

Publications205 found, 100 shown here

  1. ncbi Mutation screening in dilated cardiomyopathy: prominent role of the beta myosin heavy chain gene
    Eric Villard
    INSERM Unité 621, IFR14, CIB Pitié Salpêtrière, 91 Bd de l Hopital, 75013 Paris, France
    Eur Heart J 26:794-803. 2005
    ..Here, we performed a mutation analysis of four genes involved in FDCM in a population of idiopathic DCM...
  2. ncbi A 7.1 kbp beta-myosin heavy chain promoter, efficient for green fluorescent protein expression, probably induces lethality when overexpressing a mutated transforming growth factor-beta type II receptor in transgenic mice
    Severine Allegra
    UMR 369 INSERM UCBL and IFR 62 Laënnec
    Transgenic Res 14:69-80. 2005
    ..Analysis of the consequences of the blocking of the TGFbeta signalling pathway in the heart will require the use of tissue specific means of conditional gene invalidation...
  3. ncbi Activation of the beta myosin heavy chain promoter by MEF-2D, MyoD, p300, and the calcineurin/NFATc1 pathway
    Joachim D Meissner
    Department of Physiology, Hannover Medical School, Hannover, Germany
    J Cell Physiol 211:138-48. 2007
    ..Together, our findings demonstrate calcium-ionophore-induced activation of the beta MyHC promoter by NFATc1, MyoD, MEF-2D, and p300 in a calcineurin-dependent manner...
  4. ncbi Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy
    Pascale Richard
    UF de Cardiogénétique et Myogénétique, Service de Biochimie B, Hopital de la Salpetriere, 47 Bld de l Hopital, 75651 Paris Cedex 13, France
    Circulation 107:2227-32. 2003
    ..The aim of the present study was to perform a systematic screening of these genes in a large population, to evaluate the distribution of the disease genes, and to determine the best molecular strategy in clinical practice...
  5. pmc Structural interpretation of the mutations in the beta-cardiac myosin that have been implicated in familial hypertrophic cardiomyopathy
    I Rayment
    Institute for Enzyme Research, Graduate School, University of Wisconsin, Madison 53705 4098, USA
    Proc Natl Acad Sci U S A 92:3864-8. 1995
    ..kindreds, the disease is caused by > 29 missense mutations in the cardiac beta-myosin heavy chain (MYH7) gene...
  6. pmc Molecular cloning and characterization of human cardiac alpha- and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atrium
    M Kurabayashi
    Third Department of Internal Medicine, University of Tokyo, Japan
    J Clin Invest 82:524-31. 1988
    ..Finally, we demonstrate that MHC isozymic transition in pressure-overloaded atrium is, at least in part, regulated at a pretranslational level...
  7. ncbi A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation
    A A Geisterfer-Lowrance
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Cell 62:999-1006. 1990
    ..The pathology resulting from a missense mutation at residue 403 further suggests that a critical function of myosin is disrupted by this mutation...
  8. ncbi Mutation in myosin heavy chain 6 causes atrial septal defect
    Yung Hao Ching
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Nat Genet 37:423-8. 2005
    ..These data provide evidence for a link between a transcription factor, a structural protein and congenital heart disease...
  9. ncbi Prevalence of cardiac beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy
    Andreas Perrot
    Kardiologie am Campus Buch und Virchow Klinikum, Charité Universitätsmedizin Berlin und Max Delbrück Centrum für Molekulare Medizin, Wiltbergstrasse 50, 13125 Berlin, Germany
    J Mol Med (Berl) 83:468-77. 2005
    ..Mutations in the cardiac beta-myosin heavy chain gene (MYH7) are responsible for the disease in about 30% of cases where mutations were identified...
  10. ncbi Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy
    M Kamisago
    Cardiovascular Division, Brigham and Women s Hospital, and Harvard Medical School and Howard Hughes Medical Institute, Boston, MA, USA
    N Engl J Med 343:1688-96. 2000
    ..To elucidate this important cause of heart failure, we investigated other genetic causes of dilated cardiomyopathy...
  11. pmc Prognostic implications of novel beta cardiac myosin heavy chain gene mutations that cause familial hypertrophic cardiomyopathy
    R Anan
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    J Clin Invest 93:280-5. 1994
    ..Phe513Cys mutation (P < 0.001) support the hypothesis that mutations which alter the charge of the encoded amino acid affect survival more significantly than those that produce a conservative amino acid change...
  12. ncbi Prevalence and severity of "benign" mutations in the beta-myosin heavy chain, cardiac troponin T, and alpha-tropomyosin genes in hypertrophic cardiomyopathy
    Sara L Van Driest
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minn 55905, USA
    Circulation 106:3085-90. 2002
    ..associated with near-normal survival: N232S, G256E, F513C, V606M, R719Q, and L908V of beta-myosin heavy chain (MYH7); S179F of troponin T (TNNT2); and D175N of alpha-tropomyosin (TPM1)...
  13. doi Genotype phenotype correlations of cardiac beta-myosin heavy chain mutations in Indian patients with hypertrophic and dilated cardiomyopathy
    Taranjit Singh Rai
    Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Mol Cell Biochem 321:189-96. 2009
    The aim of the current study was to determine the frequency of mutations in the beta-myosin heavy chain gene (MYH7) in a cohort of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) and their families, and to investigate ..
  14. pmc Independent origin of identical beta cardiac myosin heavy-chain mutations in hypertrophic cardiomyopathy
    H Watkins
    Cardiology Division, Brigham and Women s Hospital, Boston, MA
    Am J Hum Genet 53:1180-5. 1993
    ..This finding predicts the prevalence of disease-causing beta cardiac MHC mutations to be comparable in all population groups...
  15. ncbi Malignant hypertrophic cardiomyopathy caused by the Arg723Gly mutation in beta-myosin heavy chain gene
    M Enjuto
    Molecular Cardiology Laboratory, Laboratory of Clinical Biochemistry and the Cardiovascular Institute, Hospital Clinic IDIBAPS, University of Barcelona, Villarroel 170, Barcelona, 08036, Spain
    J Mol Cell Cardiol 32:2307-13. 2000
    ..Mean survival of affected members was 51 years. In conclusion, a new mutation Arg723Gly in beta-myosin heavy chain gene is reported which shortens life expectancy because of sudden death and end-stage heart failure...
  16. ncbi Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy
    H Watkins
    Cardiology Division, Brigham and Women s Hospital, Boston, MA
    N Engl J Med 326:1108-14. 1992
    ..However, neither the proportion of cases attributable to myosin mutations nor the effects of different mutations on clinical outcome are known...
  17. ncbi Troponin T and beta-myosin mutations have distinct cardiac functional effects in hypertrophic cardiomyopathy patients without hypertrophy
    Miriam Revera
    Department of Cardiology, IRCCS San Matteo Hospital, Pavia, Italy
    Cardiovasc Res 77:687-94. 2008
    ..The aims of this study were to investigate whether distinct HCM-mutations have different consequences for cardiac structure and function in the absence of the confounding effects of hypertrophy...
  18. pmc Cardiomyopathy mutations reveal variable region of myosin converter as major element of cross-bridge compliance
    B Seebohm
    Molecular and Cell Physiology, Medical School, Hannover, Germany
    Biophys J 97:806-24. 2009
    ..Because amino acids 719 and 723 are nonconserved residues, cross-bridge stiffness may well be specifically tuned for different myosins...
  19. ncbi The complete sequence of the human beta-myosin heavy chain gene and a comparative analysis of its product
    T Jaenicke
    Max Planck Institut for Medical Research, Department of Cell Physiology, Heidelberg, Federal Republic of Germany
    Genomics 8:194-206. 1990
    ..We have isolated and sequenced the gene and the cDNA coding for the human cardiac beta-myosin heavy chain (designated MYH7). The gene is 22,883 bp long. The 1935 amino acids of this protein (Mr223,111) are encoded by 38 exons...
  20. pmc The origins of hypertrophic cardiomyopathy-causing mutations in two South African subpopulations: a unique profile of both independent and founder events
    J C Moolman-Smook
    US MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch Medical School, Tygerberg, South Africa
    Am J Hum Genet 65:1308-20. 1999
    ..The milder phenotype of the betaMHC mutations may account for the presence of these founder effects, whereas population dynamics alone may have overridden the reproductive disadvantage incurred by the more lethal, cTnT Arg92Trp mutation...
  21. ncbi [Demonstration of a fifth locus implicated in familial hypertrophic cardiomyopathies]
    C Hengstenberg
    INSERM U153, , Paris
    Arch Mal Coeur Vaiss 87:1655-62. 1994
    ..The first morbid gene implicated in the disease was the gene coding the beta myosin heavy chain (beta MHC) on chromosome 14. However, only 30% of families have this genetic abnormality...
  22. ncbi The influence of dietary salt and plasma renin activity on myosin heavy chain gene expression in rat hearts
    P Buttrick
    Montefiore Medical Center, Bronx, NY 10467
    Am J Hypertens 6:579-85. 1993
    ..Heart weight and heart/body weight ratios were increased only in animals with Htn. The ratio of alpha/beta myosin heavy chain (MHC) mRNA was significantly decreased with Htn...
  23. ncbi Activity of the beta-myosin heavy chain antisense promoter responds to diabetes and hypothyroidism
    Julia Giger
    Department of Physiology and Biophysics, University of California, Irvine, D 346, Med Sci I, Irvine, CA 92697, USA
    Am J Physiol Heart Circ Physiol 292:H3065-71. 2007
    ..We conclude that there is an intergenic promoter that is active in the AS direction and that the putative RAR element is a vital regulatory site...
  24. pmc Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background
    Sakthivel Sadayappan
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Ohio, USA
    Circulation 119:1253-62. 2009
    ..We determined the effect(s) of cMyBP-C phosphorylation in a beta-MyHC transgenic mouse heart in which >80% of the alpha-MyHC was replaced by beta-MyHC, which is the predominant myosin isoform in human cardiac muscle...
  25. ncbi Role of antisense RNA in coordinating cardiac myosin heavy chain gene switching
    Fadia Haddad
    Department of Physiology and Biophysics, University of California, Irvine, California 92697 4560, USA
    J Biol Chem 278:37132-8. 2003
    A novel mechanism of regulation of cardiac alpha and beta myosin heavy chain gene by naturally occurring antisense transcription was elucidated via pre-mRNA analysis...
  26. ncbi Hypertrophic cardiomyopathy: low frequency of mutations in the beta-myosin heavy chain (MYH7) and cardiac troponin T (TNNT2) genes among Spanish patients
    Monica Garcia-Castro
    Genética Molecular Instituto de Investigación Nefrológica IRSIN FRIAT and Servicio de Cardiología, Hospital Central de Asturias, 33006 Oviedo, Spain
    Clin Chem 49:1279-85. 2003
    Mutations in the cardiac beta-myosin heavy chain (MYH7) and cardiac troponin T (TNNT2) genes are reportedly responsible for up to 40% of familial cases with hypertrophic cardiomyopathy (HC)...
  27. pmc Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy
    R Patel
    Section of Cardiology, Department of Medicine, The DeBakey Heart Center, The Methodist Hospital and Baylor College of Medicine, Houston, Texas, USA
    Circulation 104:317-24. 2001
    ..These findings highlight the need for clinical trials to determine the effects of simvastatin on cardiac hypertrophy, fibrosis, and dysfunction in humans with hypertrophic cardiomyopathy and heart failure...
  28. pmc Mutations of the beta myosin heavy chain gene in hypertrophic cardiomyopathy: critical functional sites determine prognosis
    A Woo
    Division of Cardiology, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Heart 89:1179-85. 2003
    To assess patients with different types of mutations of the beta myosin heavy chain (beta MHC) gene causing hypertrophic cardiomyopathy (HCM) and to determine the prognosis of patients according to the affected functional domain of beta ..
  29. ncbi Mutation of Arg723Gly in beta-myosin heavy chain gene in five Chinese families with hypertrophic cardiomyopathy
    Jun Hua Yang
    Department of Cardiology, First Affiliated Hospital of Soochow University, Suzhou 215006, China
    Chin Med J (Engl) 119:1785-9. 2006
    ..This study was to reveal the disease-causing gene mutations in Chinese population with HCM, and to analyze the correlation between the genotype and phenotype...
  30. ncbi Role of mitogen-activated protein kinase pathway in reactive oxygen species-mediated endothelin-1-induced beta-myosin heavy chain gene expression and cardiomyocyte hypertrophy
    Tzu Hurng Cheng
    Department of Medicine, Taipei Medical University Wan Fang Hospital, Taiwan
    J Biomed Sci 12:123-33. 2005
    ..These data demonstrate the involvement of ROS in ET-1-induced hypertrophic responses and beta-MyHC expression. ROS mediate ET-1-induced activation of MAPK pathways, which culminates in hypertrophic responses and beta-MyHC expression...
  31. ncbi The effect of isoproterenol on phospholamban-deficient mouse hearts with altered thyroid conditions
    A G Brittsan
    Departments of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0575, USA
    J Mol Cell Cardiol 31:1725-37. 1999
    ..These findings suggest that phospholamban is an important regulator of the heart's responses to beta -adrenergic stimulation under various thyroid states...
  32. ncbi Role of myocyte-specific enhancer-binding factor (MEF-2) in transcriptional regulation of the alpha-cardiac myosin heavy chain gene
    E A Adolph
    Department of Medicine, University of Cincinnati College of Medicine, Ohio 45267 0575
    J Biol Chem 268:5349-52. 1993
    ..In addition, cardiac-specific expression of the transgene was perturbed with significant levels of ectopic expression occurring in the aorta...
  33. ncbi Heavy long-term ethanol consumption induces an alpha- to beta-myosin heavy chain isoform transition in rat
    J Meehan
    University of Illinois at Chicago, Department of Physiology and Biophysics, 60612, USA
    Basic Res Cardiol 94:481-8. 1999
    ..A functional consequence of this transition in MHC phenotype is demonstrated by significant decreases in the myofibrillar and myosin ATPase activities...
  34. ncbi Impact of beta-myosin heavy chain isoform expression on cross-bridge cycling kinetics
    Veronica L M Rundell
    Center for Cardiovascular Research, Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Am J Physiol Heart Circ Physiol 288:H896-903. 2005
    ..05 (ANOVA)] Thus cross-bridge cycling, under high strain, for alpha-MHC is three times higher than for beta-MHC. Furthermore, under isometric conditions, alpha-MHC and beta-MHC cross bridges hydrolyze ATP independently of one another...
  35. ncbi Diastolic dysfunction without left ventricular hypertrophy is an early finding in children with hypertrophic cardiomyopathy-causing mutations in the beta-myosin heavy chain, alpha-tropomyosin, and myosin-binding protein C genes
    Tuija Poutanen
    Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland
    Am Heart J 151:725.e1-725.e9. 2006
    ..We investigated the presence of left ventricular hypertrophy (LVH) and features of diastolic dysfunction in genotype-confirmed children from families with hypertrophic cardiomyopathy (HCM) and healthy control children...
  36. pmc Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone
    Susan Lowey
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    J Biol Chem 283:20579-89. 2008
    ..Thus, the functional consequences of the mutation are fundamentally changed depending upon the context of the cardiac MHC isoform...
  37. ncbi Different phenotypes among slow/beta myosin heavy chain-containing fibres of rabbit masseter muscle: a novel type of diversity in adult muscle
    A W English
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, USA
    J Muscle Res Cell Motil 19:525-35. 1998
    ..We feel that it is a regulated process and that, at least for some phenotypes, this regulation may be hormonally influenced...
  38. ncbi Simultaneous quantification of human cardiac alpha- and beta-myosin heavy chain proteins by MALDI-TOF mass spectrometry
    Steve M Helmke
    Proteomics Facility, Box C 238, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
    Anal Chem 76:1683-9. 2004
    ..This method is of general applicability, especially when isoform quantification is required...
  39. ncbi Increased beta-myosin heavy chain in acute cellular rejection following human heart transplantation
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Kaufman Center for Heart Failure, OH, USA
    Am J Transplant 2:386-8. 2002
    ..However, altered expression of beta-myosin heavy chain in human cardiac rejection has not been determined...
  40. ncbi Dissociation of left ventricular hypertrophy, beta-myosin heavy chain gene expression, and myosin isoform switch in rats after ascending aortic stenosis
    R J Wiesner
    Department of Physiology, University of Heidelberg, Germany
    Circulation 95:1253-9. 1997
    ..In the present investigation, beta-MHC gene expression was studied in an experimental model of pressure-over-load hypertrophy that is not associated with a concurrent activation of the circulating renin-angiotensin system...
  41. ncbi Long-term alcohol administration inhibits synthesis of both myofibrillar and sarcoplasmic proteins in heart
    Thomas C Vary
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Metabolism 54:212-9. 2005
    ..We conclude that translational control mechanisms appear to be important in regulating the expression of myocardial proteins during long-term ethanol intoxication...
  42. doi The CAAT-binding transcription factor 1/nuclear factor 1 binding site is important in beta-myosin heavy chain antisense promoter regulation in rats
    Julia M Giger
    Department of Physiology and Biophysics, University of California, Irvine, D 346, Medical Sciences Building I, Irvine, CA 92697, USA
    Exp Physiol 94:1163-73. 2009
    ..Based on these findings, we conclude that the NF1 site is critical to betaAS promoter regulation...
  43. ncbi Human homozygous R403W mutant cardiac myosin presents disproportionate enhancement of mechanical and enzymatic properties
    Dagmar I Keller
    INSERM U582, Institut de Myologie, , , 47, , 75651 Paris Cedex 13, France
    J Mol Cell Cardiol 36:355-62. 2004
    ..Most families present mutations in MYBPC3 and MYH7 encoding cardiac myosin-binding protein C and beta-myosin heavy chain...
  44. ncbi Analysis of myosin heavy chain functionality in the heart
    Maike Krenz
    Cincinnati Children s Hospital Medical Center, The Children s Hospital Research Foundation, MLC 7020, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 278:17466-74. 2003
    ..In mouse cardiac isoforms, myosin functionality does not depend on Loop 1 or Loop 2 sequences and must lie partially in other non-homologous residues...
  45. pmc Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod
    Emily Flashman
    Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre of Human Genetics, Oxford OX3 7BN, UK
    Biochem J 401:97-102. 2007
    ..We investigated this interaction in detail to determine whether HCM mutations in beta myosin heavy chain located within the LMM portion alter the binding of cMyBP-C, and to define the precise region of LMM that ..
  46. ncbi A MyoD1-independent muscle-specific enhancer controls the expression of the beta-myosin heavy chain gene in skeletal and cardiac muscle cells
    W R Thompson
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital, Boston, Massachusetts
    J Biol Chem 266:22678-88. 1991
    ..These observations provide evidence for the existence of myogenic regulatory programs that precede and/or differ from those governed by known myogenic helix-loop-helix transactivators...
  47. pmc Effects of cardiac myosin isoform variation on myofilament function and crossbridge kinetics in transgenic rabbits
    Takeki Suzuki
    Department of Medicine, Cardiology Unit, Fletcher Allen Health Care, Burlington, VT 05401, USA
    Circ Heart Fail 2:334-41. 2009
    ..This study was undertaken to identify a myofilament-based mechanism underlying tachycardia-induced cardiomyopathy protection and to extrapolate the impact of MHC isoform variation on myofilament function in human hearts...
  48. ncbi Myopathies associated with myosin heavy chain mutations
    A Oldfors
    Department of Pathology, Sahlgrenska University Hospital, Goteborg, Sweden
    Acta Myol 23:90-6. 2004
    ..Three major MyHC isoforms are expressed in human skeletal muscle (type I, MYH7, expressed in type 1 fibres; IIa, MYH2, expressed in 2A fibres; IIx, MYH1, expressed in 2B fibres)...
  49. ncbi Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein
    C Redwood
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Circ Res 86:1146-52. 2000
    ..cardiomyopathy (HCM) is caused by mutations in at least 8 contractile protein genes, most commonly beta myosin heavy chain, myosin binding protein C, and cardiac troponin T...
  50. pmc Tissue Doppler imaging consistently detects myocardial contraction and relaxation abnormalities, irrespective of cardiac hypertrophy, in a transgenic rabbit model of human hypertrophic cardiomyopathy
    S F Nagueh
    Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Circulation 102:1346-50. 2000
    ....
  51. pmc Enhanced transmural fiber rotation and connexin 43 heterogeneity are associated with an increased upper limit of vulnerability in a transgenic rabbit model of human hypertrophic cardiomyopathy
    Crystal M Ripplinger
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Circ Res 101:1049-57. 2007
    ....
  52. ncbi [Genetic causes of hypertrophic cardiomyopathy]
    H P Vosberg
    Max Planck Institut fur Physiologische und Klinische Forschung, Abteilung Experimentelle Kardiologie, Bad Nauheim
    Med Klin (Munich) 93:252-9. 1998
    ....
  53. doi Clinical features and outcome of hypertrophic cardiomyopathy associated with triple sarcomere protein gene mutations
    Francesca Girolami
    Unit for Genetic Diagnosis, Careggi University Hospital, Florence, Italy
    J Am Coll Cardiol 55:1444-53. 2010
    ..The aim of this study was to describe the clinical profile associated with triple sarcomere gene mutations in a large hypertrophic cardiomyopathy (HCM) cohort...
  54. ncbi Subclinical skeletal muscle abnormalities in patients with hypertrophic cardiomyopathy and their relation to clinical characteristics
    Aris Anastasakis
    Department of Cardiology, University of Athens, Hippokration Hospital, Athens, Greece
    Int J Cardiol 89:249-56. 2003
    ....
  55. pmc The molecular genetic basis for hypertrophic cardiomyopathy
    A J Marian
    Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Mol Cell Cardiol 33:655-70. 2001
    ..Understanding the pathogenesis of HCM could provide for genetic based diagnosis, risk stratification, treatment and prevention of cardiac phenotypes...
  56. ncbi Cocaine produces cardiac hypertrophy by protein kinase C dependent mechanisms
    Robert J Henning
    Department of Medicine, University of South Florida College of Medicine and the James A Haley Hospital, Tampa, Florida, USA
    J Cardiovasc Pharmacol Ther 8:149-60. 2003
    ..We determined whether cocaine directly increases cardiomyocyte protein content and whether protein kinase C is important in this process...
  57. ncbi Atrial natriuretic factor and brain natriuretic peptide gene expression in the spontaneous hypertensive rat during postnatal development
    M L Kuroski de Bold
    Department of Pathology, University of Ottawa Heart Institute, Ottawa Civic Hospital, ON, Canada
    Am J Hypertens 11:1006-18. 1998
    ..The regulation of NP is not coordinated in either gender during the development of hypertension. The activation of the BNP gene in female SHR suggests that BNP might play an important role at the onset of hypertension...
  58. ncbi Cocaine activates calcium/calmodulin kinase II and causes cardiomyocyte hypertrophy
    Robert J Henning
    Department of Medicine, University of South Florida College of Medicine and the James A Haley VA Hospital, Tampa, Florida 33612, USA
    J Cardiovasc Pharmacol 48:802-13. 2006
    ..6%, and beta-MHC by 66.2% (P < 0.01) and significantly decreased cocaine-induced Ca transients and [Ca]i. We conclude that CaMKII activation is an important mechanism whereby cocaine can cause myocyte hypertrophy...
  59. ncbi Altered cardiac hormone and contractile protein messenger RNA levels following left ventricular myocardial infarction in the rat: an in situ hybridization histochemical study
    R L Young
    University of Melbourne, Department of Medicine, Austin, Australia
    Cardiovasc Res 37:187-201. 1998
    ..The present study examined the spatiotemporal expression of cardiac contractile protein and peptide hormone mRNA following left ventricular myocardial infarction (LVMI) in the rat heart...
  60. ncbi [Genetics of dilated cardiomyopathy]
    K J Osterziel
    Franz Volhard Klinik Charité Humboldt Universität zu Berlin 13122 Berlin, Germany
    Z Kardiol 90:461-9. 2001
    ..Better understanding of the expression and function of disease genes may eventually result in new diagnostic and therapeutic tools in order to improve the prognosis of this severe disorder...
  61. ncbi [Genetics of hereditary cardiopathies]
    S Debrus
    CRBM, CNRS UPR 9008 et INSERM U249, Montpellier
    Arch Mal Coeur Vaiss 89:619-27. 1996
    Hypertrophic cardiomyopathy may be secondary to a mutation in the cardiac beta myosin heavy chain (14q11-q12), alpha tropomyosin (15q22), troponin T (1q32), protein C gene (11p11-q13) or in a non yet mapped gene...
  62. doi Insights into human beta-cardiac myosin function from single molecule and single cell studies
    Sivaraj Sivaramakrishnan
    Department of Biochemistry, Stanford University, Stanford, CA, USA
    J Cardiovasc Transl Res 2:426-40. 2009
    ..Thirty percent of the point mutations that result in hypertrophic cardiomyopathy are localized to MYH7, the gene encoding human beta-cardiac myosin heavy chain (beta-MyHC)...
  63. ncbi Combined effects of ramipril and angiotensin II receptor blocker TCV116 on rat congestive heart failure after myocardial infarction
    Ze wei Tao
    Department of Cardiology, Chinese People Armed Police Force Hospital of Hunan Province, Changsha 410006, China
    Chin Med J (Engl) 118:146-54. 2005
    ..The present study was conducted to examine the combined effects of a chronic ACEI, ramipril, and a chronic Ang II type 1 receptor blocker, TCV116, on rat CHF after myocardial infarction (MI)...
  64. ncbi Increased protein kinase C activity in myotrophin-induced myocyte growth
    P Sil
    Department of Molecular Cardiology, The Lerner Research Institute, The Cleveland Clinic Foundation, Ohio 44195, USA
    Circ Res 82:1173-88. 1998
    ..Our data suggest that myotrophin exerts its action on protein synthesis, possibly through a tyrosine kinase-coupled pathway and translocation of PKC from the cytosol to the cell membrane...
  65. ncbi Novel cell lines derived from adult human ventricular cardiomyocytes
    Mercy M Davidson
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Mol Cell Cardiol 39:133-47. 2005
    ..These cell lines are potentially useful in vitro models to study developmental regulation of cardiomyocytes in normal and pathological states...
  66. ncbi [Clinical features of dilated cardiomyopathy-like hypertrophic cardiomyopathy caused by a 13261 G > A mutation in cardiac myosin-binding protein C gene]
    Shu xia Wang
    Sino German Laboratory for Molecular Medicine, Fu Wai Cardiovascular Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
    Zhonghua Xin Xue Guan Bing Za Zhi 35:17-20. 2007
    ..To study the disease-causing gene mutation in Chinese patients with hypertrophic cardiomyopathy (HCM) and to analyze the genotype and phenotype correlation...
  67. doi Genetic and clinical profile of Indian patients of idiopathic restrictive cardiomyopathy with and without hypertrophy
    Taranjit Singh Rai
    Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Mol Cell Biochem 331:187-92. 2009
    ..We studied a group of patients with restrictive physiology for mutations in beta-myosin heavy chain (MYH7) and troponin I (TNNI3) gene...
  68. ncbi Expression of proto-oncogenes and gene mutation of sarcomeric proteins in patients with hypertrophic cardiomyopathy
    H Kai
    From the Cardiovascular Research Institute, Kurume University and the Third Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan
    Circ Res 83:594-601. 1998
    ..It is possible that ss-MHC gene mutation has some effect on the regulation of proto-oncogene expression in HCM...
  69. pmc Evidence of MyomiR network regulation of beta-myosin heavy chain gene expression during skeletal muscle atrophy
    John J McCarthy
    Department of Physiology, College Health Sciences, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Physiol Genomics 39:219-26. 2009
    ..These results further expand the role of miRs in adult skeletal muscle and are consistent with a model in which the MyomiR network regulates slow myosin expression during muscle atrophy...
  70. ncbi Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice
    Michiel Ten Hove
    Department of Cardiovascular Medicine, University of Oxford, Oxford, England
    Circulation 111:2477-85. 2005
    ..To characterize the role of a substantially impaired CK/PCr system in heart, we studied the cardiac phenotype of wild-type (WT) and GAMT-/- mice...
  71. ncbi Gender differences in molecular remodeling in pressure overload hypertrophy
    E O Weinberg
    Charles A Dana Research Institute, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 34:264-73. 1999
    ..The objective of this study was to examine gender differences in left ventricular (LV) function and expression of cardiac genes in response to LV pressure overload due to ascending aortic stenosis in rats...
  72. ncbi The antioxidant tempol inhibits cardiac hypertrophy in the insulin-resistant GLUT4-deficient mouse in vivo
    R H Ritchie
    Molecular Pharmacology Laboratory, Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, St Kilda Road Central, Melbourne, VIC 8008, Australia
    J Mol Cell Cardiol 42:1119-28. 2007
    ..Antioxidants may offer new alternatives in this disorder...
  73. ncbi Ral GDP dissociation stimulator and Ral GTPase are involved in myocardial hypertrophy
    Miki Kawai
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 2, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Hypertension 41:956-62. 2003
    ..SATA3 may play a key role in Ral-GDS expression and Ral activation. Our data provide evidence that the Ral-GDS/Ral signaling pathway is a link to the process of cardiac hypertrophy...
  74. ncbi Rescuing the N-cadherin knockout by cardiac-specific expression of N- or E-cadherin
    Y Luo
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 128:459-69. 2001
    ....
  75. doi Familial ebstein anomaly, left ventricular hypertrabeculation, and ventricular septal defect associated with a MYH7 mutation
    Audra L Bettinelli
    Medical Genetics Department, Ochsner Clinic Foundation, New Orleans, Louisiana
    Am J Med Genet A 161:3187-90. 2013
    ..investigations of a rare case of familial Ebstein anomaly in association with a likely pathogenic mutation of the MYH7 gene...
  76. doi Coronary telangiectasia associated with hypertrophic cardiomyopathy
    Andrea Frustaci
    Cardiovascular, Respiratory, Nephrologic and Geriatric Sciences Department, La Sapienza University, Rome, Italy
    Eur J Heart Fail 14:1332-7. 2012
    ..Its prevalence, genetic background, and impact in human hypertrophic cardiomyopathy (HCM) are unknown and were therefore investigated in this study...
  77. ncbi Molecular characterisation of neonatal cardiac hypertrophy and its regression
    Bamini Gopinath
    Department of Molecular and Clinical Genetics, Royal Prince Alfred Hospital, and Central Clinical School, The University of Sydney, NSW, Australia
    Cardiol Young 14:498-505. 2004
    ..Hypertrophic regression provides a unique model for the testing of new drugs or genetic modifying factors in cardiac hypertrophy...
  78. ncbi Effects of triiodo-thyronine on angiotensin-induced cardiomyocyte hypertrophy: reversal of increased beta-myosin heavy chain gene expression
    Baohua Wang
    Department of Pathophysiology, School of Medicine, Wuhan University, Wuhan 430071, P R China
    Can J Physiol Pharmacol 84:935-41. 2006
    ..Thyroid hormone appears to be able to reprogram gene expression in Ang II-induced cardiac hypertrophy, and a PKC signal pathway may be involved in such remodeling process...
  79. pmc Distribution of histone3 lysine 4 trimethylation at T3-responsive loci in the heart during reversible changes in gene expression
    Kumar Pandya
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    Gene Expr 15:183-98. 2012
    ..modifications are induced primarily at 5' transcribed region in parallel with increased expression of beta myosin heavy chain (MHC)...
  80. pmc Terminal differentiation of Sol 8 myoblasts is retarded by a transforming growth factor-beta autocrine regulatory loop
    Severine Allegra
    UMR 369 INSERM UCBL and IFR 62 Laënnec, Faculte de Medecine, R T H Laennec, 7 rue G Paradin, 69372 Lyon, Cedex 08, France
    Biochem J 381:429-36. 2004
    ..To conclude, TGFbeta inhibits Sol 8 cell terminal differentiation within a narrow time interval (24-34 h) that coincides with the onset of betaMHC expression...
  81. pmc Crystal structure of silkworm Bombyx mori JHBP in complex with 2-methyl-2,4-pentanediol: plasticity of JH-binding pocket and ligand-induced conformational change of the second cavity in JHBP
    Zui Fujimoto
    Biomolecular Research Unit, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    PLoS ONE 8:e56261. 2013
    ..of the silkworm Bombyx mori JHBP in complex with two molecules of 2-methyl-2,4-pentanediol (MPD), one molecule (MPD1) bound in the JH-binding pocket while the other (MPD2) in a second cavity...
  82. doi Determination of deployment specific chemical uptake rates for SPMD and PDMS using a passive flow monitor
    Dominique O'Brien
    The University of Queensland, National Research Centre for Environmental Toxicology EnTox, 39 Kessels Rd, Coopers Plains, QLD 4108, Australia
    Mar Pollut Bull 64:1005-11. 2012
    ..the passive flow monitor (PFM) can be applied to predict changes in R(s) dependent on flow when using the absorbent SPMD (semipermeable membrane device) and PDMS (polydimethyl siloxan) passive samplers...
  83. ncbi Prevalence and distribution of sarcomeric gene mutations in Japanese patients with familial hypertrophic cardiomyopathy
    Haruna Otsuka
    Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Japan
    Circ J 76:453-61. 2012
    ..Although there are several reports on the systematic screening of mutations in the disease-causing genes in European and American populations, only limited information is available for Asian populations, including Japanese...
  84. ncbi [Genetic heterogeneity of myosin heavy chain 7 gene G823E mutation in familial hypertrophic cardiomyopathy in Chinese]
    Hu Wang
    Sino German Laboratory for Molecular Medicine, Fuwai Cardiovascular Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100037, China
    Zhonghua Yi Xue Za Zhi 88:3120-2. 2008
    ..To study the disease-causing gene mutations in familial hypertrophic cardiomyopathy (HCM) in Chinese and to reveal the relationship between the genotype and the phenotype...
  85. pmc Hypertrophic cardiomyopathy: from genetics to treatment
    Ali J Marian
    Center for Cardiovascular Genetics, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center and Texas Heart Institute at St Luke s Episcopal Hospital, 6770 Bertner Street, Suite C900A, Houston, TX 77030, USA
    Eur J Clin Invest 40:360-9. 2010
    ..Hypertrophic cardiomyopathy (HCM) is the prototypic form of pathological cardiac hypertrophy. HCM is an important cause of sudden cardiac death in the young and a major cause of morbidity in the elderly...
  86. ncbi Effect of cardiac resynchronization therapy on myocardial gene expression in patients with nonischemic dilated cardiomyopathy
    Srinivas Iyengar
    Division of Cardiovascular Medicine and the Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210 1252, USA
    J Card Fail 13:304-11. 2007
    ....
  87. doi Development of a high resolution melting method for the detection of genetic variations in hypertrophic cardiomyopathy
    Gilles Millat
    Laboratoire de Cardiogénétique Moléculaire, Centre de biologie et pathologie est, Hospices Civils de Lyon, Lyon, France
    Clin Chim Acta 411:1983-91. 2010
    ....
  88. doi Enalapril decreases cardiac mass and fetal gene expression without affecting the expression of endothelin-1, transforming growth factor β-1, or cardiotrophin-1 in the healthy normotensive rat
    Katarina Mackovicova
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Slovakia
    Can J Physiol Pharmacol 89:197-205. 2011
    ..Left ventricular expression of cardiac myosin heavy chain-α (MYH6) and -β (MYH7), atrial natriuretic peptide (ANP), endothelin-1 (ET-1), transforming growth factor β-1 (TGFβ-1), cardiotrophin-1 ..
  89. pmc Unequal allelic expression of wild-type and mutated β-myosin in familial hypertrophic cardiomyopathy
    Snigdha Tripathi
    Institute of Molecular and Cell Physiology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Basic Res Cardiol 106:1041-55. 2011
    ..about 30% of the patients is caused by missense mutations in one allele of the β-myosin heavy chain (β-MHC) gene (MYH7)...
  90. pmc Myozenin 2 is a novel gene for human hypertrophic cardiomyopathy
    Adriana Osio
    Center for Cardiovascular Genetic Research, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX 77030, USA
    Circ Res 100:766-8. 2007
    ..We excluded MYH7, MYBPC3, TNNT2, and ACTC1 as the causal gene either by direct sequencing or by haplotype analysis...
  91. doi A novel mutation of the beta myosin heavy chain gene responsible for familial hypertrophic cardiomyopathy
    Juan Wang
    Department of Cardiovascular Medicine, East Hospital, Tongji University, Shanghai, China
    Clin Cardiol 32:E16-21. 2009
    ..The genetic etiology responsible for HCM in many individuals remains unclear...
  92. ncbi Calcium-independent negative inotropy by beta-myosin heavy chain gene transfer in cardiac myocytes
    Todd J Herron
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109 0622, USA
    Circ Res 100:1182-90. 2007
    ..We conclude that beta-MyHC is a negative inotrope among the cardiac myofilament proteins...
  93. ncbi The acute phase protein alpha2-macroglobulin induces rat ventricular cardiomyocyte hypertrophy via ERK1,2 and PI3-kinase/Akt pathways
    Manju Padmasekar
    Department of Physiology, Justus Liebig University Giessen, Aulweg 129, 35392 Giessen, Germany
    Cardiovasc Res 75:118-28. 2007
    ....
  94. ncbi Concentration of organochlorine pollutants in surface waters of the central European biosphere reserve Krivoklatsko
    Vladimir Koci
    Department of Environmental Chemistry, ICT Prague, Technicka 5, 166 28 Prague 6, Czech Republic
    Environ Sci Pollut Res Int 14:94-101. 2007
    ..This work publishes data of the contamination with organochlorine pollutants of this natural region, where biodiversity and ecological functions are of the highest order...
  95. ncbi [Family hypertrophic cardiomyopathy caused by a 14035c > t mutation in cardiac troponin T gene]
    Shu xia Wang
    Sino German Laboratory for Molecular Medicine, FuWai Cardiovascular Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences, Beijing 100037, China
    Zhonghua Yi Xue Za Zhi 87:371-4. 2007
    ..To study the disease-causing gene mutation in Chinese patients with familial hypertrophic cardiomyopathy (FHC) and to analyze the correlation between the genotype and the phenotype...
  96. ncbi Cardiac myosin isoforms from different species have unique enzymatic and mechanical properties
    Ulf P Malmqvist
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405 0068, USA
    Biochemistry 43:15058-65. 2004
    ..Thus, nature has adapted the function of cardiac myosin isoforms to optimize power output for hearts of a given species...
  97. ncbi [Desorption of polycyclic aromatic hydrocarbons in soils assisted by SPMD]
    Hong Wen Sun
    College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China
    Huan Jing Ke Xue 28:1841-6. 2007
    ..bioavailability of hydrophobic organic chemicals (HOCs) in soils, a method using semi-permeable membrane device (SPMD) to study desorption of HOCs in soils has been set up, and assisted desorption of polycyclic aromatic hydrocarbons (..
  98. pmc A novel custom resequencing array for dilated cardiomyopathy
    Rebekah S Zimmerman
    Laboratory for Molecular Medicine, Partners Healthcare Center for Personalized Genetic Medicine, Cambridge, Massachusetts 02139, USA
    Genet Med 12:268-78. 2010
    ..Novel sequencing platforms have now opened up avenues for more comprehensive diagnostic testing while simultaneously decreasing test cost and turn around time...
  99. doi Application of semipermeable membrane device (SPMD) to assess air genotoxicity in an occupational environment
    Sa Bonetta
    Department of Environmental and Life Sciences, University of Piemonte Orientale A Avogadro, Via Bellini 25 G, 15100 Alessandria, Italy
    Chemosphere 75:1446-52. 2009
    Semipermeable membrane device (SPMD) is a passive sampler that sequesters lipophilic contaminants, mimicking the bioconcentration in the fatty tissue of organisms...
  100. pmc Crystal structures of human cardiac beta-myosin II S2-Delta provide insight into the functional role of the S2 subfragment
    Wulf Blankenfeldt
    Max Planck Institute of Molecular Physiology, Department of Physical Biochemistry, 44227 Dortmund, Germany
    Proc Natl Acad Sci U S A 103:17713-7. 2006
    ..The observation that many disease-associated mutations affect the second negatively charged ring further suggests that charge interactions play an important role in regulation of cardiac muscle activity through myosin-binding protein C...
  101. ncbi Characterization of anti-myosin monoclonal antibodies
    P N Nelson
    Molecular Immunology Research Group, Research Institute in Healthcare Science, School of Applied Sciences, University of Wolverhampton, Wolverhampton, United Kingdom
    Hybridoma (Larchmt) 24:314-8. 2005
    ..Hence, it is speculated that this region could give some credence to the mechanism of molecular mimicry associated with some cardiac diseases. Overall, MAb H1 may serve as a useful probe of myosin structure...

Research Grants75

  1. Cardiac Channel Mutations in Sudden Infant Death Syndrome (SIDS)
    Michael Ackerman; Fiscal Year: 2007
    ....
  2. Cooperative Regulation of Cardiac MHC Genes.
    KENNETH BALDWIN; Fiscal Year: 2006
    In preliminary studies we made the novel observation that the expression of the beta myosin heavy chain (MHC) gene is likely under the control of two promoters: 1) a 5'beta promoter (5 'beta) that transcribes pre-mRNA in the sense ..
  3. ACTIVITY & METABOLIC CONTROL OF CARDIAC B MYOSIN
    KENNETH BALDWIN; Fiscal Year: 2001
    ..pressure overload, and diabetes are capable of up regulating, to varying degrees, the expression of the beta myosin heavy chain (MHC) gene in the rodent heat...
  4. Molecular Epidemiology of Dilated Cardiomyopath
    Luisa Mestroni; Fiscal Year: 2005
    ..abstract_text> ..
  5. PTH RELATED PROTEIN IN VASCULAR SMOOTH MUSCLE
    Thomas Clemens; Fiscal Year: 2004
    ..We will determine the consequence of cardiac-specific ablation of PTHrP and its receptor on heart development by crossing a beta-myosin heavy chain driven Cre mouse with the PTHrP and PTHrP and PTHrP-R floxed mice. ..
  6. PTH RELATED PROTEIN IN VASCULAR SMOOTH MUSCLE
    Thomas Clemens; Fiscal Year: 2003
    ..We will determine the consequence of cardiac-specific ablation of PTHrP and its receptor on heart development by crossing a beta-myosin heavy chain driven Cre mouse with the PTHrP and PTHrP and PTHrP-R floxed mice. ..
  7. MANNITOL AND VIRULENCE IN CRYPTOCOCCUS NEOFORMANS
    Brian Wong; Fiscal Year: 2002
    ..Therefore, he will (i) clone and sequence the C. neoformans MPD structural gene (MPD1), (ii) construct mpd1 null mutants, and (iii) test these mutants for their abilities to synthesize and catabolize ..
  8. ALTERED MECHANICAL LOADS AND SKELETAL MUSCLE PHENOTYPE
    Richard Tsika; Fiscal Year: 2004
    ..abstract_text> ..
  9. EXERCISE HYPERTROPHY AND CONTROL OF MYOSIN INDUCTION
    Richard Tsika; Fiscal Year: 2001
    ..determining the DNA regulatory element(s) and nuclear protein factor(s) which transcriptionally induce beta myosin heavy chain expression in mechanical overloaded plantaris muscle and to test their possible role in fiber specific ..
  10. EXERCISE HYPERTROPHY AND CONTROL OF MYOSIN INDUCTION
    Richard Tsika; Fiscal Year: 2007
    ..abstract_text> ..
  11. ALTERED MECHANICAL LOADS AND SKELETAL MUSCLE PHENOTYPE
    Richard Tsika; Fiscal Year: 2009
    ..abstract_text> ..
  12. Cardiac Channel Mutations in Sudden Infant Death Syndrome (SIDS)
    MICHAEL JOHN ACKERMAN; Fiscal Year: 2010
    ....
  13. Cardiac Channel Mutations in SIDS
    Michael Ackerman; Fiscal Year: 2005
    ..Such a discovery could have significant implications on attempts to further reduce the incidence of SIDS in our country and throughout the world. ..
  14. Familial Dilated Cardiomyopathy: Detection/Gene Mapping
    Ray Hershberger; Fiscal Year: 2006
    ..We further propose to (2) map the genes responsible for FDC in several FDC pedigrees, of which linkage and additional gene mapping studies are in progress. ..
  15. Familial Dilated Cardiomyopathy: Detection/Gene Mapping
    Ray E Hershberger; Fiscal Year: 2010
    ..We aim to identify more of the disease genes, which will lead to greater understanding of the causes of human heart failure. ..
  16. Familial Dilated Cardiomyopathy: Detection/Gene Mapping
    Ray Hershberger; Fiscal Year: 2009
    ..We aim to identify more of the disease genes, which will lead to greater understanding of the causes of human heart failure. ..