MYH11

Summary

Gene Symbol: MYH11
Description: myosin heavy chain 11
Alias: AAT4, FAA4, SMHC, SMMHC, myosin-11, myosin heavy chain, smooth muscle isoform, myosin, heavy chain 11, smooth muscle, myosin, heavy polypeptide 11, smooth muscle
Species: human
Products:     MYH11

Top Publications

  1. Zhu L, Vranckx R, Khau Van Kien P, Lalande A, Boisset N, Mathieu F, et al. Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus. Nat Genet. 2006;38:343-9 pubmed
    ..2-p13.13 (ref. 3). We now demonstrate that the disease is caused by mutations in the MYH11 gene affecting the C-terminal coiled-coil region of the smooth muscle myosin heavy chain, a specific contractile ..
  2. Alhopuro P, Phichith D, Tuupanen S, Sammalkorpi H, Nybondas M, Saharinen J, et al. Unregulated smooth-muscle myosin in human intestinal neoplasia. Proc Natl Acad Sci U S A. 2008;105:5513-8 pubmed publisher
    A recent study described a recessive ATPase activating germ-line mutation in smooth-muscle myosin (smmhc/myh11) underlying the zebrafish meltdown (mlt) phenotype...
  3. Nogi M, Satoh K, Sunamura S, Kikuchi N, Satoh T, Kurosawa R, et al. SmgGDS Prevents Thoracic Aortic Aneurysm Formation and Rupture by Phenotypic Preservation of Aortic Smooth Muscle Cells. Circulation. 2018;: pubmed publisher
    ..Moreover, expressions of FBN1, ACTA2, MYH11, MLK and PRKG1, which are force generation genes, were significantly reduced in Apoe-/-..
  4. Xu H, Du S, Fang B, Li C, Jia X, Zheng S, et al. VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure. Proc Natl Acad Sci U S A. 2019;116:8457-8462 pubmed publisher
    ..and a marked reduction in α-SM actin (α-SMA), SM22α, and SM differentiation marker genes myosin heavy chain (SMMHC) levels and serum response factor (SRF) transcriptional activity...
  5. Zhang Q, Hossain D, Duttagupta P, Moreira D, Zhao X, Won H, et al. Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia. Blood. 2016;127:1687-700 pubmed publisher
    ..CpG-STAT3dODN effectively reducedCbfb/MYH11/MplAML burden in various organs and eliminated leukemia stem/progenitor cells, mainly through CD8/CD4 T-cell-..
  6. Lacey M, Baribault C, Ehrlich K, Ehrlich M. Atherosclerosis-associated differentially methylated regions can reflect the disease phenotype and are often at enhancers. Atherosclerosis. 2019;280:183-191 pubmed publisher
    ..aorta α2 smooth muscle actin), ELN (elastin), MYOCD (myocardin), C9orf3 (miR-23b and miR-27b host gene), and MYH11 (smooth muscle myosin)...
  7. Hata Y, Hirono K, Yamaguchi Y, Ichida F, Oku Y, Nishida N. Minimal inflammatory foci of unknown etiology may be a tentative sign of early stage inherited cardiomyopathy. Mod Pathol. 2019;: pubmed publisher
    ..one variant), and the remaining 10 variants occurred in seven cases (DSC2, RYR2, SOS1, SCN5A, SGCD, LPL, PKP2, MYH11, GATA6, and DSG2). All mutations were missense mutations. DSP_Lys1581Glu and DSC2_p...
  8. Darwiche R, Mène Saffrané L, Gfeller D, Asojo O, Schneiter R. The pathogen-related yeast protein Pry1, a member of the CAP protein superfamily, is a fatty acid-binding protein. J Biol Chem. 2017;292:8304-8314 pubmed publisher
    ..vitro, and its function was essential for fatty acid export in cells lacking the acyl-CoA synthetases Faa1 and Faa4. Fatty acid binding of Pry1 is independent of its capacity to bind sterols, and the two sterol- and fatty acid-..
  9. Kumar V, Aneesh K, Kshemada K, Ajith K, Binil R, Deora N, et al. Amalaki rasayana, a traditional Indian drug enhances cardiac mitochondrial and contractile functions and improves cardiac function in rats with hypertrophy. Sci Rep. 2017;7:8588 pubmed publisher
    ..In heart tissues of AR administered rats of both the groups, SERCA2, CaM, Myh11, antioxidant, autophagy, oxidative phosphorylation and TCA cycle proteins were up regulated...

More Information

Publications131 found, 100 shown here

  1. Ustiyan V, Bolte C, Zhang Y, Han L, Xu Y, Yutzey K, et al. FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme. Dev Biol. 2018;443:50-63 pubmed publisher
    ..Finally, deletion of Foxf1 from smooth muscle cell lineage (smMHC-Cre Foxf1-/-) caused hyper-extension of esophagus and trachea, loss of tracheal and esophageal muscle, ..
  2. Akhter A, Mughal M, Elyamany G, Sinclair G, Azma R, Masir N, et al. Multiplexed automated digital quantification of fusion transcripts: comparative study with fluorescent in-situ hybridization (FISH) technique in acute leukemia patients. Diagn Pathol. 2016;11:89 pubmed publisher
    ..CBFB-MYH11 fusion probes showed moderate sensitivity (57 %) but high specificity (100 %)...
  3. Wei L, Wang Q, Zhang Y, Yang C, Guan H, Chen Y, et al. Identification of key genes, transcription factors and microRNAs involved in intracranial aneurysm. Mol Med Rep. 2017;: pubmed publisher
    ..In addition, nitric oxide synthase 1 (NOS1), a target of miRNA?125b, and myosin heavy chain 11 (MYH11), a target of minichromosome maintenance complex component 4 (MCM4), had higher degree scores in the integrated ..
  4. Han L, Peng Y, Zhang Y, Chen W, Lin Y, Wang Q. Designing and Creating a Synthetic Omega Oxidation Pathway in Saccharomyces cerevisiae Enables Production of Medium-Chain ?, ?-Dicarboxylic Acids. Front Microbiol. 2017;8:2184 pubmed publisher
    ..Furthermore, the deletion of fatty acyl-CoA synthetase genes FAA1 and FAA4 increased the production of medium-chain ?, ?-DCAs from 4.690 ± 0.088 mg/L to 12.177 ± 0...
  5. Struski S, Lagarde S, Bories P, Puiseux C, Prade N, Cuccuini W, et al. NUP98 is rearranged in 3.8% of pediatric AML forming a clinical and molecular homogenous group with a poor prognosis. Leukemia. 2017;31:565-572 pubmed publisher
    ..8%), a frequency similar to CBFB-MYH11 fusion gene (4.0%). The most frequent NUP98 fusion gene partner is NSD1...
  6. Tejima K, Ishiai M, Murayama S, Iwatani S, Kajiwara S. Candida albicans fatty acyl-CoA synthetase, CaFaa4p, is involved in the uptake of exogenous long-chain fatty acids and cell activity in the biofilm. Curr Genet. 2018;64:429-441 pubmed publisher
    ..cerevisiae Scfaa1-Scfaa4 double mutant in the presence of cerulenin. On the other hand, a C. albicans faa4 mutant was unable to grow in the presence of cerulenin even if LCFAs were provided exogenously...
  7. Iaconetti C, De Rosa S, Polimeni A, Sorrentino S, Gareri C, Carino A, et al. Down-regulation of miR-23b induces phenotypic switching of vascular smooth muscle cells in vitro and in vivo. Cardiovasc Res. 2015;107:522-33 pubmed publisher
    ..the expression of VSMC marker genes such as smooth muscle α-actin (ACTA2) and smooth muscle myosin heavy chain (MYH11). Overexpression of miR-23b in balloon-injured arteries by Ad-miR-23b markedly decreased neointimal hyperplasia...
  8. Yoon J, Kim H, Park S, Jeon Y, Lee S, Cho B, et al. Clinical Outcome of Autologous Hematopoietic Cell Transplantation in Adult Patients with Acute Myeloid Leukemia: Who May Benefit from Autologous Hematopoietic Cell Transplantation?. Biol Blood Marrow Transplant. 2017;23:588-597 pubmed publisher
    ..minimal residual disease (MRD) such as WT1 and core-binding factor (CBF) associated MRD (ie, AML1/ETO and CBFβ/MYH11)...
  9. Wen Q, Wang Y, Tang J, Cheng C, Liu Y. Sertoli Cell Wt1 Regulates Peritubular Myoid Cell and Fetal Leydig Cell Differentiation during Fetal Testis Development. PLoS ONE. 2016;11:e0167920 pubmed publisher
    ..Specifically, the expression of PMC marker genes α-Sma, Myh11 and Des, and interstitial progenitor cell marker gene Vcam1 were down-regulated, whereas FLC marker genes StAR, ..
  10. Shoyele O, Gupta G. Synchronous Diagnosis of De Novo Acute Myeloid Leukemia with inv(16)(p13q22) and Chronic Lymphocytic Leukemia: A Case Report and Review of the Literature. Ann Clin Lab Sci. 2018;48:790-796 pubmed
    ..In conjunction with cytogenetics studies, a diagnosis of de novo AML with inv(16)(p13q22) CBFB-MYH11, trisomy 8, monosomy 18, and concurrent CLL with trisomy 12 was made...
  11. Senel U, Coskun O, Tuysuz E, Sahin M, Bayrak O, Cakmak B, et al. Smooth muscle cell differentiation from rabbit amniotic cells. Exp Mol Pathol. 2018;105:395-403 pubmed publisher
    ..Our results indicate that AMSCs change their morphology and exhibit increased expression of ACTA2 and MYH11, which was confirmed via qPCR and ICC...
  12. Lu C, Liu M, Clinton M, Culshaw G, Argyle D, Corcoran B. Developmental pathways and endothelial to mesenchymal transition in canine myxomatous mitral valve disease. Vet J. 2015;206:377-84 pubmed publisher
    ..and TLR4), basement membrane disarray (NID1, LAMA2 and CTSS), mesenchymal and endothelial cell differentiation (MYH11 and TAGLN) and EndoMT (ACTA2, SNAI1, CTNNB1, HAS2, CDH5, and NOTCH1), with fold changes from +15.35 (ACTA2) to -5...
  13. Xi W, Liu Y, Sun X, Shan J, Yi L, Zhang T. Bioinformatics analysis of RNA-seq data revealed critical genes in colon adenocarcinoma. Eur Rev Med Pharmacol Sci. 2017;21:3012-3020 pubmed
    ..Several critical genes were disclosed, such as MYH11, COL5A2 and ribosomal proteins...
  14. Jorgensen B, Berent R, Ha S, Horiguchi K, Sasse K, Becker L, et al. DNA methylation, through DNMT1, has an essential role in the development of gastrointestinal smooth muscle cells and disease. Cell Death Dis. 2018;9:474 pubmed publisher
    ..Additionally, there is a marked loss of differentiated SMC markers (Srf, Myh11, miR-133, miR-143/145), an increase in pro-apoptotic markers (Nr4a1, Gadd45g), loss of cellular connectivity, and ..
  15. Kondo J, Powell A, Wang Y, Musser M, Southard Smith E, Franklin J, et al. LRIG1 Regulates Ontogeny of Smooth Muscle-Derived Subsets of Interstitial Cells of Cajal in Mice. Gastroenterology. 2015;149:407-19.e8 pubmed publisher
    ..Lrig1-CreERT2 mice or mice with CreERT2 under control of an inducible smooth muscle promoter (Myh11-CreERT2) were crossed with Rosa26-LSL-YFP mice for lineage tracing analysis...
  16. Yang X, Shi J, Zhang X, Zhang G, Zhang J, Yang S, et al. Expression level of GAS6-mRNA influences the prognosis of acute myeloid leukemia patients with allogeneic hematopoietic stem cell transplantation. Biosci Rep. 2019;: pubmed publisher
    ..022), lower percentage of type M5 (p=0.034), lower percentage of inv(16)/CBF-MYH11 karyotype (p=0.020) and lower rate of Good Risk classification (p=0...
  17. Le T, Pickett H, dos Remedios C, Barbaro P, Kizana E, Chong J. Platelet Derived Growth Factor Receptor-Alpha expressing cardiac progenitor cells can be derived from previously cryopreserved human heart samples. Stem Cells Dev. 2017;: pubmed publisher
    ..Multipotent potential was confirmed using in-vitro differentiation assays with smooth muscle (MYH11+), endothelial cell (vWF+) and cardiomyocyte-like (cTnT+, ?-actinin+) cell formation...
  18. Karimi A, Milewicz D. Structure of the Elastin-Contractile Units in the Thoracic Aorta and How Genes That Cause Thoracic Aortic Aneurysms and Dissections Disrupt This Structure. Can J Cardiol. 2016;32:26-34 pubmed publisher
    ..encode structural proteins in the SMC contractile unit, including ACTA2, which encodes SMC-specific α-actin and MYH11, which encodes SMC-specific myosin heavy chain, along with MYLK and PRKG1, which encode kinases that control SMC ..
  19. Liu L, Li E, Li F, Luo L, Zhao S, Kang R, et al. Effect of Testosterone on the Phenotypic Modulation of Corpus Cavernosum Smooth Muscle Cells in a Castrated Rat Model. Urology. 2017;103:273.e1-273.e6 pubmed publisher
    ..CCSM cells undergo phenotype modulation in castrated rats, whereas T reversed the alterations. T may play a key role in the phenotype modulation of CCSM cells. ..
  20. Hillebrand M, Millot N, Sheikhzadeh S, Rybczynski M, Gerth S, Kölbel T, et al. Total serum transforming growth factor-β1 is elevated in the entire spectrum of genetic aortic syndromes. Clin Cardiol. 2014;37:672-9 pubmed publisher
    ..004), and in NOTCH1 mutations vs ACTA2/MYH11 mutations (P = 0.015). Similarly, tsTGF-β1 levels were elevated in MFS (P = 0.003) and in BAVD (P = 0...
  21. Shin Y, Jeon Y, Jung N, Park J, Park H, Jung S. Substrate-specific gene expression profiles in different kidney cell types are associated with Fabry disease. Mol Med Rep. 2015;12:5049-57 pubmed publisher
    ..In the HK‑2 cells, the ADAMTS6, BEST1, IL4, and MYH11 genes were upregulated...
  22. Bakela K, Athanassakis I. Soluble MHC molecules in immune regulation: Highlighting class II antigens. Immunology. 2017;: pubmed publisher
    ..Although secretion mechanisms have not been sufficiently studied, sMHC molecules have been shown to display important immunoregulatory properties...
  23. He R, Wiktor A, Hanson C, Ketterling R, Kurtin P, Van Dyke D, et al. Conventional karyotyping and fluorescence in situ hybridization: an effective utilization strategy in diagnostic adult acute myeloid leukemia. Am J Clin Pathol. 2015;143:873-8 pubmed publisher
    ..FISH lent prognostic information in one (0.5%) of 220 cases with normal karyotype/abnormal FISH: CBFB-MYH11 fusion, indicating favorable prognosis...
  24. Pajoohesh M, Naderi Manesh H, Soleimani M. MicroRNA-145-based differentiation of human mesenchymal stem cells to smooth muscle cells. Biotechnol Lett. 2016;38:1975-1981 pubmed
    ..PCR analysis indicated significant upregulation of SMC markers, including SM-?-actin, calponin, caldesmon and SMMHC, in SMCs compared to hBM-MSCs...
  25. Yu L, Wang J, Wang S, Zhang D, Zhao Y, Wang R, et al. DNA Methylation Regulates Gene Expression in Intracranial Aneurysms. World Neurosurg. 2017;105:28-36 pubmed publisher
    ..Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses and verification analysis showed that the MYH11, LIFR, and TLR4 genes were associated with the occurrence and development of intracranial aneurysms...
  26. Hayashi N, Manyam G, Gonzalez Angulo A, Niikura N, Yamauchi H, Nakamura S, et al. Reverse-phase protein array for prediction of patients at low risk of developing bone metastasis from breast cancer. Oncologist. 2014;19:909-14 pubmed publisher
    ..cell cycle or signal transduction (CDK2, CDKN1A, Rb1, Src, phosphorylated-ribosomal S6 kinase, HER2, BCL11A, and MYH11)...
  27. Alvarez S, Suela J, Valencia A, Fernández A, Wunderlich M, Agirre X, et al. DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia. PLoS ONE. 2010;5:e12197 pubmed publisher
    ..In contrast, fusion genes such as AML1/ETO or CBFB/MYH11 failed to reproduce the epigenetic signature observed in the patients...
  28. Isselbacher E, Lino Cardenas C, Lindsay M. Hereditary Influence in Thoracic Aortic Aneurysm and Dissection. Circulation. 2016;133:2516-28 pubmed publisher
    ..The second set of genes encode components of the smooth muscle contractile apparatus (ACTA2, MYH11, MYLK, and PRKG1), a group called the smooth muscle contraction vasculopathies...
  29. Fang M, Yu C, Chen S, Xiong W, Li X, Zeng R, et al. Identification of Novel Clinically Relevant Variants in 70 Southern Chinese patients with Thoracic Aortic Aneurysm and Dissection by Next-generation Sequencing. Sci Rep. 2017;7:10035 pubmed publisher
    ..5%). Among the 27 VUS, 14 (51.9%) were in the FBN1 gene, 3 in Col5A2, 2 in ACTA2, 2 in MYH11, 2 in MYLK, 2 in SLC2A10, 1 in MSTN and 1 in SMAD3 respectively...
  30. Gomez D, Swiatlowska P, Owens G. Epigenetic Control of Smooth Muscle Cell Identity and Lineage Memory. Arterioscler Thromb Vasc Biol. 2015;35:2508-16 pubmed publisher
    ..repertoire of genes that are expressed in differentiated SMC, including SMC-selective marker genes like Acta2 and Myh11, as well as housekeeping genes expressed by most cell types...
  31. Qi J, Singh S, Hua W, Cai Q, Chao S, Li L, et al. HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation. Cell Stem Cell. 2015;17:597-610 pubmed publisher
    ..Here, we show that p53 activity is inhibited in inv(16)(+) AML LSCs via interactions with the CBFβ-SMMHC (CM) fusion protein and histone deacetylase 8 (HDAC8)...
  32. Leber C, Polson B, Fernandez Moya R, Da Silva N. Overproduction and secretion of free fatty acids through disrupted neutral lipid recycle in Saccharomyces cerevisiae. Metab Eng. 2015;28:54-62 pubmed publisher
    ..Disruptions in the acyl-CoA synthetase genes FAA1, FAA4 and FAT1 allowed the extracellular detection of free fatty acids up to 490mg/L...
  33. Ji Y, Chen S, Xiang B, Li Y, Li L, Wang Q. Jagged1/Notch3 Signaling Modulates Hemangioma-Derived Pericyte Proliferation and Maturation. Cell Physiol Biochem. 2016;40:895-907 pubmed
    ..Notch3 signaling upregulated the expression of the pericyte contractile markers smooth muscle myosin heavy chain (smMHC) and α-smooth muscle actin (αSMA), concomitant with an increase in the expression of myocardin in Hem-pericytes...
  34. Cheung C, Bernardo A, Trotter M, Pedersen R, Sinha S. Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility. Nat Biotechnol. 2012;30:165-73 pubmed publisher
    ..These intermediate populations were further differentiated toward SMCs (>80% MYH11(+) and ACTA2(+)), which displayed contractile ability in response to vasoconstrictors and invested perivascular ..
  35. Brun J, Abruzzese T, Rolauffs B, Aicher W, Hart M. Choice of xenogenic-free expansion media significantly influences the myogenic differentiation potential of human bone marrow-derived mesenchymal stromal cells. Cytotherapy. 2016;18:344-59 pubmed publisher
    ..growth factors TGFβ1, PDGF and ascorbic acid induced high expression of ACTA2, TAGLN, CNN1 and/or MYH11 contractile SMC markers. Osteogenic, adipogenic and chondrogenic differentiations served as controls...
  36. Jiao J, Xiong W, Wang L, Yang J, Qiu P, Hirai H, et al. Differentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves. EBioMedicine. 2016;10:282-90 pubmed publisher
    ..NCSC-derived SMCs, these cells demonstrated significantly decreased expression of marker of SMC differentiation (MYH11) and impaired contraction compared to normal control...
  37. Villacis R, Basso T, Canto L, Pinheiro M, Santiago K, Giacomazzi J, et al. Rare germline alterations in cancer-related genes associated with the risk of multiple primary tumor development. J Mol Med (Berl). 2017;95:523-533 pubmed publisher
    ..by both rare CNVs and cnLOH, including 14 related to tumorigenesis and seven genes (ABCC1, KDM4C, KIAA0430, MYH11, NDE1, PIWIL2, and ULK2) specifically associated with cellular growth and proliferation...
  38. Xia X, Zhou Z, Yu X, Zheng X, Tang C. Myocardin: A novel player in atherosclerosis. Atherosclerosis. 2017;257:266-278 pubmed publisher
    ..target genes can transcriptionally activate a variety of downstream muscle-specific genes, such as Sm22?, Acta2, Myh11, and several other signaling pathways...
  39. Aouida M, Li L, Mahjoub A, Alshareef S, Ali Z, Piatek A, et al. Transcription activator-like effector nucleases mediated metabolic engineering for enhanced fatty acids production in Saccharomyces cerevisiae. J Biosci Bioeng. 2015;120:364-71 pubmed publisher
    ..Heterodimeric TALENs were designed to simultaneously edit the FAA1 and FAA4 genes encoding acyl-CoA synthetases in S. cerevisiae...
  40. Ferreira R, Skrekas C, Nielsen J, David F. Multiplexed CRISPR/Cas9 Genome Editing and Gene Regulation Using Csy4 in Saccharomyces cerevisiae. ACS Synth Biol. 2018;7:10-15 pubmed publisher
    ..cerevisiae. In regards to genome editing, we performed a quadruple deletion of FAA1, FAA4, POX1 and TES1 reaching 96% efficiency out of 24 colonies tested...
  41. Wei H, Wang Y, Zhou C, Lin D, Liu B, Liu K, et al. Distinct genetic alteration profiles of acute myeloid leukemia between Caucasian and Eastern Asian population. J Hematol Oncol. 2018;11:18 pubmed publisher
    ..5, 12.5, 9.3, 10.2, and 12%, respectively). And CBFbeta-MYH11 occurred more prevalently in HOVON/SAKK AML- 42 and ECOG1900 trials (50.0 and 54...
  42. Tsuchio Y, Naito S, Nogami A, Hoshizaki H, Oshima S, Taniguchi K, et al. Intracoronary serum smooth muscle myosin heavy chain levels following PTCA may predict restenosis. Jpn Heart J. 2000;41:131-40 pubmed
    Recently a novel biochemical method that uses an immunoassay to quantitate serum smooth muscle myosin heavy chain (SMMHC) levels was developed for diagnosis of aortic dissection...
  43. Yeung K, Bogunovic N, Keekstra N, Beunders A, Pals J, van der Kuij K, et al. Transdifferentiation of Human Dermal Fibroblasts to Smooth Muscle-Like Cells to Study the Effect of MYH11 and ACTA2 Mutations in Aortic Aneurysms. Hum Mutat. 2017;38:439-450 pubmed publisher
    ..to study the effect of variants in genes encoding proteins of the SMC contractile apparatus (ACTA2 and MYH11) in patients with aortic aneurysms...
  44. van der Reijden B, Dauwerse J, Wessels J, Beverstock G, Hagemeijer A, van Ommen G, et al. A gene for a myosin peptide is disrupted by the inv(16)(p13q22) in acute nonlymphocytic leukemia M4Eo. Blood. 1993;82:2948-52 pubmed
    ..The gene, which codes for a myosin peptide, is disrupted by the inversion of chromosome 16 in the 5 patients. To the best of our knowledge, this is the first report of a myosin gene disrupted in leukemia. ..
  45. Douet Guilbert N, Chauveau A, Gueganic N, Guillerm G, Tous C, LE Bris M, et al. Acute myeloid leukaemia (FAB AML-M4Eo) with cryptic insertion of cbfb resulting in cbfb-Myh11 fusion. Hematol Oncol. 2017;35:385-389 pubmed publisher
    ..They generate a 5'CBFB-3'MYH11 fusion gene...
  46. Moreno C, Metze K, Lomazi E, Bertola D, Barbosa R, Cosentino V, et al. Visceral myopathy: Clinical and molecular survey of a cohort of seven new patients and state of the art of overlapping phenotypes. Am J Med Genet A. 2016;170:2965-2974 pubmed publisher
    ..conditions recently begun to be clarified with the identification of pathogenic variants in ACTG2, ACTA2, and MYH11 in individuals with visceral motility dysfunction...
  47. New L, Jiang Y, Zhao M, Liu K, Zhu W, Flood L, et al. PRAK, a novel protein kinase regulated by the p38 MAP kinase. EMBO J. 1998;17:3372-84 pubmed
    ..An in-gel kinase assay demonstrated that PRAK is a major stress-activated kinase that can phosphorylate small heat shock protein, suggesting a potential role for PRAK in mediating stress-induced HSP27 phosphorylation in vivo. ..
  48. Goikuria H, Freijo M, Vega Manrique R, Sastre M, Elizagaray E, Lorenzo A, et al. Characterization of Carotid Smooth Muscle Cells during Phenotypic Transition. Cells. 2018;7: pubmed publisher
    ..i>MYH11, CNN1, SRF, MKL2, and CALD1 were significantly underexpressed in VSMCs from ..
  49. Yuan F, Wang D, Xu K, Wang J, Zhang Z, Yang L, et al. Contribution of Vascular Cells to Neointimal Formation. PLoS ONE. 2017;12:e0168914 pubmed publisher
    ..In vitro and in vivo analysis of MYH11-cre/Rosa-loxP-RFP mouse artery showed that SMCs proliferated at a much slower rate than non-SMCs...
  50. Crawford J, Hsieh C, Schenning R, Slater M, Landry G, Moneta G, et al. Genetics, Pregnancy, and Aortic Degeneration. Ann Vasc Surg. 2016;30:158.e5-9 pubmed publisher
    ..One such mutation is the myosin heavy chain gene (MYH11) which is responsible for 1-2% of all FTAAD cases...
  51. Martins L, Francisconi dos Rios L, Meira G, Bertocco V, Silva L, Rebelo M. Amazonian delicacy tucupi is as erosive as a cola-based soft drink. Arch Oral Biol. 2016;61:84-8 pubmed publisher
    ..tucupi's ability to promote erosion of bovine enamel by assessing its percentage of surface microhardness change (%SMHC), taking a cola-based soft drink and human saliva as positive and negative controls...
  52. Li H, Zhang T, Xu L, Tang Y, Cui H, Wei Y, et al. A comparison of conversion rates, clinical profiles and predictors of outcomes in two independent samples of individuals at clinical high risk for psychosis in China. Schizophr Res. 2017;: pubmed publisher
    ..on the ascertainment and outcomes of "clinical high risk" (CHR) individuals at the Shanghai Mental Health Center (SMHC, "2011 cohort")...
  53. Chen F, He S, Shan H, Zhang H, Lian Y, Wei A. [Effect of platelet-derived growth factor-BB on rat corpus cavernosum smooth muscle cell proliferation, migration and phenotypic modulation]. Nan Fang Yi Ke Da Xue Xue Bao. 2015;35:971-6 pubmed
    ..assay; the mRNA expression of the transcription factor myocardin and the contractile phenotype markers αSMA and SMMHC in CCSM cells were determined by qRT-PCR at 24 h and 48 h...
  54. Bailey S, Haggarty J, Kelly S. Global absenteeism and presenteeism in mental health patients referred through primary care. Work. 2015;53:399-408 pubmed publisher
    ..Analysis of 11 years of patient data collected in a Shared Mental Health Care (SMHC) clinic referred within a primary care setting in Ontario, Canada...
  55. Ji H, Atchison L, Chen Z, Chakraborty S, Jung Y, Truskey G, et al. Transdifferentiation of human endothelial progenitors into smooth muscle cells. Biomaterials. 2016;85:180-194 pubmed publisher
    ..By day 7, the reprogrammed cells show upregulation of smooth muscle markers ACTA2, MYH11, and TAGLN by qRT-PCR and ACTA2 and MYH11 expression by immunofluorescence...
  56. Ouyang J, Goswami M, Peng J, Zuo Z, Daver N, Borthakur G, et al. Comparison of Multiparameter Flow Cytometry Immunophenotypic Analysis and Quantitative RT-PCR for the Detection of Minimal Residual Disease of Core Binding Factor Acute Myeloid Leukemia. Am J Clin Pathol. 2016;145:769-77 pubmed publisher
    ..We studied 42 patients with t(8;21)(q22;q22)/RUNX1-RUNX1T1 and 51 with inv(16)(p13.1q22)/CBFB-MYH11 Tandem MRD analyses by MFC and quantitative reverse transcription polymerase chain reaction (qRT-PCR) were ..
  57. Biebel K, Ryder Burge A, Alikhan S, Ringeisen H, Ellison M. Strategies to Support the Education Goals of Youth and Young Adults with Serious Mental Health Conditions: A Case Study. Adm Policy Ment Health. 2018;45:661-671 pubmed publisher
    This manuscript describes efforts to support youth and young adults living with serious mental health conditions (SMHC) as they pursue their education goals...
  58. Huang K, Yang M, Pan Z, Heidel F, Scherr M, Eder M, et al. Leukemogenic potency of the novel FLT3-N676K mutant. Ann Hematol. 2016;95:783-91 pubmed publisher
    ..the cooperation between FLT3-N676K and core binding factor ß-smooth muscle myosin heavy chain (CBFß-SMMHC) (encoded by the inv(16) chimeric gene CBFB-MYH11) in inducing acute leukemia, and tested the sensitivity of FLT3-..
  59. Moreno C, Sobreira N, Pugh E, Zhang P, Steel G, Torres F, et al. Homozygous deletion in MYL9 expands the molecular basis of megacystis-microcolon-intestinal hypoperistalsis syndrome. Eur J Hum Genet. 2018;26:669-675 pubmed publisher
    ..to be defined recently, and the genes related to the syndrome (ACTG2-heterozygous variant in sporadic cases; and MYH11 (myosin heavy chain 11), LMOD1 (leiomodin 1) and MYLK (myosin light chain (MLC) kinase)-autosomal recessive ..
  60. Ziganshin B, Bailey A, Coons C, Dykas D, Charilaou P, Tanriverdi L, et al. Routine Genetic Testing for Thoracic Aortic Aneurysm and Dissection in a Clinical Setting. Ann Thorac Surg. 2015;100:1604-11 pubmed publisher
    ..panel was tested by WES: ACTA2, ADAMTS10, COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, ELN, FBLN4, FLNA, FBN1, FBN2, MYH11, MYLK, NOTCH1, PRKG1, SLC2A10, SMAD3, TGFB2, TGFBR1, TGFBR2. Seventy-four patients (72...
  61. Tang F, Xu L, Zhang X, Chen H, Chen Y, Han W, et al. Monitoring of post-transplant CBFB-MYH11 as minimal residual disease, rather than KIT mutations, can predict relapse after allogeneic haematopoietic cell transplantation in adults with inv(16) acute myeloid leukaemia. Br J Haematol. 2018;180:448-451 pubmed publisher
  62. Eisfeld A, Kohlschmidt J, Schwind S, Nicolet D, Blachly J, Orwick S, et al. Mutations in the CCND1 and CCND2 genes are frequent events in adult patients with t(8;21)(q22;q22) acute myeloid leukemia. Leukemia. 2017;31:1278-1285 pubmed publisher
    ..1q22)/t(16;16)(p13.1;q22)/CBFB-MYH11. The resulting fusion genes require a 'second hit' to initiate leukemogenesis...
  63. Rautureau Y, Paradis P, Schiffrin E. Generation of a Mouse Model with Smooth Muscle Cell Specific Loss of the Expression of PPARγ. Methods Mol Biol. 2017;1527:381-407 pubmed publisher
    ..ligand binding domain (CreERT2) under the control of the smooth muscle myosin heavy chain (smmhc, myh11) with mice having loxP sites flanking exon 2 of the Pparγ gene (Pparγ Flox/Flox )...
  64. Metzeler K, Bloomfield C. Clinical Relevance of RUNX1 and CBFB Alterations in Acute Myeloid Leukemia and Other Hematological Disorders. Adv Exp Med Biol. 2017;962:175-199 pubmed publisher
    ..section, we discuss the prognostic implications of the core binding factor translocations RUNX1-RUNX1T1 and CBFB-MYH11 in AML patients...
  65. Boberg L, Szekeres F, Arner A. Signaling and metabolic properties of fast and slow smooth muscle types from mice. Pflugers Arch. 2018;470:681-691 pubmed publisher
    ..velocity were obtained from mice and classified according to expression of the inserted myosin heavy chain (SMHC-B)...
  66. Yang P, Hong M, Fu C, Schmit B, Su Y, Berceli S, et al. Preexisting smooth muscle cells contribute to neointimal cell repopulation at an incidence varying widely among individual lesions. Surgery. 2016;159:602-12 pubmed publisher
    ..R26R(+);Myh11-CreER(+), and R26R(+);Scl-CreER(+) mice were used to attach LacZ tags to the preexisting smooth muscle cells (SMCs)..
  67. Yang P, Schmit B, Fu C, Desart K, Oh S, Berceli S, et al. Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events. Sci Rep. 2016;6:35444 pubmed publisher
    ..We used an inducible Cre-loxP system driven by a Myh11 promoter to delete Tgfbr1, Tgfbr2, or both in smooth muscle cells (SMCs) of adult mice...
  68. Lahaye S, Corsmeier D, Basu M, Bowman J, Fitzgerald Butt S, Zender G, et al. Utilization of Whole Exome Sequencing to Identify Causative Mutations in Familial Congenital Heart Disease. Circ Cardiovasc Genet. 2016;9:320-9 pubmed publisher
    ..A disease-segregating splice donor site mutation in MYH11 (c...
  69. White S, Martin A, Periasamy M. Identification of a novel smooth muscle myosin heavy chain cDNA: isoform diversity in the S1 head region. Am J Physiol. 1993;264:C1252-8 pubmed
    Smooth muscle myosin heavy chain (SMHC) isoforms, SM1 and SM2, are the products of alternative splicing from a single gene (P. Babij and M. Periasamy. J. Mol. Biol. 210: 673-679, 1989)...
  70. Zhu Y, Zhang Y, Zhu P, Yang Y, Du J, Liu J. [Role of molecular screening for common fusion genes in the diagnosis and classification of leukemia]. Beijing Da Xue Xue Bao Yi Xue Ban. 2005;37:236-9 pubmed
    ..in 115 cases of leukemia, including AML1/ETO, PML/RAR alpha, PLZF/RAR alpha, dupMLL, MLL/AF6, MLL/AF10, CBFbeta/MYH11, BCR/ABL, Hox11, and EVI1 BCR/ABL was positive in all the 52 cases of chronic myeloid leukemia; PML/RAR alpha was ..
  71. van de Luijtgaarden K, Heijsman D, Maugeri A, Weiss M, Verhagen H, IJpma A, et al. First genetic analysis of aneurysm genes in familial and sporadic abdominal aortic aneurysm. Hum Genet. 2015;134:881-93 pubmed publisher
    ..factor-beta pathway genes EFEMP2, FBN1, SMAD3, TGBF2, TGFBR1, TGFBR2, and the smooth muscle cells genes ACTA2, MYH11 and MYLK. Sanger sequencing of all coding exons and exon-intron boundaries of these genes was performed...
  72. Wang Y, Ding W, Jiang F, Chen Z, Cen J, Qi X, et al. Coexistence of p210BCR-ABL and CBF?-MYH11 fusion genes in myeloid leukemia: A report of 4 cases. Oncol Lett. 2017;14:5171-5178 pubmed publisher
    ..two specific primary molecular changes, BCR-ABL and core binding factor-?-myosin heavy chain 11 (CBF?-MYH11) fusion genes have been rarely reported...
  73. Kuang S, Guo D, Prakash S, McDonald M, Johnson R, Wang M, et al. Recurrent chromosome 16p13.1 duplications are a risk factor for aortic dissections. PLoS Genet. 2011;7:e1002118 pubmed publisher
    ..b>MYH11, a gene known to predispose to TAAD, lies in the duplicated region of 16p13...
  74. Kwartler C, Chen J, Thakur D, Li S, Baskin K, Wang S, et al. Overexpression of smooth muscle myosin heavy chain leads to activation of the unfolded protein response and autophagic turnover of thick filament-associated proteins in vascular smooth muscle cells. J Biol Chem. 2014;289:14075-88 pubmed publisher
    ..The most likely candidate gene in this region leading to the predisposition for dissection is MYH11, which encodes smooth muscle myosin heavy chain (SM-MHC)...
  75. Li R, Xu Z, Mu C, Song W, Wang C. Molecular cloning and characterization of a hemocyanin from Sepiella maindroni. Fish Shellfish Immunol. 2017;67:228-243 pubmed publisher
    ..In the present study, the full-length cDNA encoding hemocyanin in Sepiella maindroni (SmHc) was cloned and characterized...
  76. Li Q, Sarna S. Nuclear myosin II regulates the assembly of preinitiation complex for ICAM-1 gene transcription. Gastroenterology. 2009;137:1051-60, 1060.e1-3 pubmed publisher
  77. Liao M, Zhou J, Wang F, Ali Y, Chan K, Zou F, et al. An X-linked Myh11-CreERT2 mouse line resulting from Y to X chromosome-translocation of the Cre allele. Genesis. 2017;55: pubmed publisher
    The Myh11-CreERT2 mouse line (Cre+ ) has gained increasing application because of its high lineage specificity relative to other Cre drivers targeting smooth muscle cells (SMCs)...
  78. Babu G, Warshaw D, Periasamy M. Smooth muscle myosin heavy chain isoforms and their role in muscle physiology. Microsc Res Tech. 2000;50:532-40 pubmed
    ..This review mainly focuses on the molecular basis of smooth muscle myosin heavy chain isoform diversity, its expression during development and disease, and its role in muscle physiology. ..
  79. Meloni I, Rubegni P, De Aloe G, Bruttini M, Pianigiani E, Cusano R, et al. Pseudoxanthoma elasticum: Point mutations in the ABCC6 gene and a large deletion including also ABCC1 and MYH11. Hum Mutat. 2001;18:85 pubmed
    ..of marker D16S405 allowed us to detect a submicroscopic deletion of at least 900 kb involving ABCC6, ABCC1, and MYH11. Mutation analysis on the other allele of the family, as well as on two additional sporadic cases, revealed ..
  80. Sammalkorpi H, Alhopuro P, Niittymäki I, Orntoft T, Hokland P, Karhu A, et al. Mutation analysis of MYH11 in acute myeloid leukemia. Leuk Lymphoma. 2008;49:1829-31 pubmed publisher
  81. Leguillette R, Laviolette M, Bergeron C, Zitouni N, Kogut P, Solway J, et al. Myosin, transgelin, and myosin light chain kinase: expression and function in asthma. Am J Respir Crit Care Med. 2009;179:194-204 pubmed publisher
    ..Selective overexpression of airway smooth muscle genes in asthmatic airways leads to increased Vmax, thus contributing to the airway hyperresponsiveness observed in asthma. ..
  82. Kamikubo Y, Hyde R, Zhao L, Alemu L, Rivas C, Garrett L, et al. The C-terminus of CBF?-SMMHC is required to induce embryonic hematopoietic defects and leukemogenesis. Blood. 2013;121:638-42 pubmed publisher
    The C-terminus of CBF?-SMMHC, the fusion protein produced by a chromosome 16 inversion in acute myeloid leukemia subtype M4Eo, contains domains for self-multimerization and transcriptional repression, both of which have been proposed to ..
  83. Schwind S, Edwards C, Nicolet D, Mrozek K, Maharry K, Wu Y, et al. inv(16)/t(16;16) acute myeloid leukemia with non-type A CBFB-MYH11 fusions associate with distinct clinical and genetic features and lack KIT mutations. Blood. 2013;121:385-91 pubmed publisher
    The inv(16)(p13q22)/t(16;16)(p13;q22) in acute myeloid leukemia results in multiple CBFB-MYH11 fusion transcripts, with type A being most frequent. The biologic and prognostic implications of different fusions are unclear...
  84. Aikawa M, Sivam P, Kuro O M, Kimura K, Nakahara K, Takewaki S, et al. Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis. Circ Res. 1993;73:1000-12 pubmed
    ..We conclude from these results that smooth muscle MHC isoforms are important molecular markers for studying human vascular smooth muscle cell differentiation as well as the cellular mechanisms of atherosclerosis. ..
  85. Deng Z, Liu P, Marlton P, Claxton D, Lane S, Callen D, et al. Smooth muscle myosin heavy chain locus (MYH11) maps to 16p13.13-p13.12 and establishes a new region of conserved synteny between human 16p and mouse 16. Genomics. 1993;18:156-9 pubmed
    The human smooth muscle myosin heavy chain locus (MYH11) was mapped by fluorescence in situ hybridization to the middle of the p arm of chromosome 16 using a genomic cosmid clone containing coding sequences of the gene as probe...
  86. Leguillette R, Gil F, Zitouni N, Lajoie Kadoch S, Sobieszek A, Lauzon A. (+)Insert smooth muscle myosin heavy chain (SM-B) isoform expression in human tissues. Am J Physiol Cell Physiol. 2005;289:C1277-85 pubmed
    ..A differential expression of the (+)insert isoform could also account for altered contractile properties observed in human pathology. ..
  87. Zhang L, D Costa J, Kummalue T, Civin C, Friedman A. Identification of a region on the outer surface of the CBFbeta-SMMHC myeloid oncoprotein assembly competence domain critical for multimerization. Oncogene. 2006;25:7289-96 pubmed
    In the core binding factor (CBF)beta-smooth muscle myosin heavy chain (SMMHC) acute myeloid leukemia (AML) oncoprotein, CBFbeta lies N-terminal to the alpha-helical rod domain of SMMHC...
  88. Sun X, Zhang W, Ramdas L, Stivers D, Jones D, Kantarjian H, et al. Comparative analysis of genes regulated in acute myelomonocytic leukemia with and without inv(16)(p13q22) using microarray techniques, real-time PCR, immunohistochemistry, and flow cytometry immunophenotyping. Mod Pathol. 2007;20:811-20 pubmed
    ..The inv(16)(p13q22) or, less commonly, the t(16;16)(p13;q22) causes fusion of the CBFbeta gene at 16q22 and the MYH11 gene at 16p13, creating the novel chimeric protein CBFbeta-MYH11...
  89. Pannu H, Tran Fadulu V, Papke C, Scherer S, Liu Y, Presley C, et al. MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II. Hum Mol Genet. 2007;16:2453-62 pubmed
    ..at the 16p locus has recently been identified as the smooth muscle cell (SMC)-specific myosin heavy chain gene (MYH11)...
  90. Milton D, Schneck A, Ziech D, Ba M, Facemyer K, Halayko A, et al. Direct evidence for functional smooth muscle myosin II in the 10S self-inhibited monomeric conformation in airway smooth muscle cells. Proc Natl Acad Sci U S A. 2011;108:1421-6 pubmed publisher
    ..This study provides unique direct evidence for the presence of a significant pool of functional myosin in the 10S conformation in cells. ..
  91. Kuang S, Kwartler C, Byanova K, Pham J, Gong L, Prakash S, et al. Rare, nonsynonymous variant in the smooth muscle-specific isoform of myosin heavy chain, MYH11, R247C, alters force generation in the aorta and phenotype of smooth muscle cells. Circ Res. 2012;110:1411-22 pubmed publisher
    Mutations in myosin heavy chain (MYH11) cause autosomal dominant inheritance of thoracic aortic aneurysms and dissections...