myeloperoxidase

Summary

Gene Symbol: myeloperoxidase
Description: myeloperoxidase
Species: human

Top Publications

  1. ncbi [Disturbed neutrophil activation in pneumonia during medicinal immunosuppression]
    J Braun
    Medizinische Klinik II,
    Pneumologie 51:1037-42. 1997
  2. ncbi Myeloperoxidase G-463A polymorphism and Alzheimer's disease in the ApoEurope study
    Brigitte Leininger-Muller
    INSERM Unite 525, Centre de Médecine Préventive and Faculté de Pharmacie, Nancy, France
    Neurosci Lett 349:95-8. 2003
  3. pmc Elevated plasma free fatty acids increase cardiovascular risk by inducing plasma biomarkers of endothelial activation, myeloperoxidase and PAI-1 in healthy subjects
    Manoj Mathew
    Diabetes Division, Department of Medicine, The University of Texas Health Science Center at San Antonio, Texas 78229, USA
    Cardiovasc Diabetol 9:9. 2010
  4. ncbi Myeloperoxidase inactivates TIMP-1 by oxidizing its N-terminal cysteine residue: an oxidative mechanism for regulating proteolysis during inflammation
    Yi Wang
    Department of Medicine, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington 98195, USA
    J Biol Chem 282:31826-34. 2007
  5. ncbi Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase
    Stephan Baldus
    Department of Cardiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Circulation 113:1871-8. 2006
  6. pmc Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer disease
    Richard A Maki
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    J Biol Chem 284:3158-69. 2009
  7. ncbi Genetic polymorphism in myeloperoxidase but not GSTM1 is associated with risk of lung squamous cell carcinoma in a Chinese population
    Wenfu Lu
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100 021, China
    Int J Cancer 102:275-9. 2002
  8. ncbi Properties, functions, and secretion of human myeloperoxidase
    J Arnhold
    Institut fur Medizinische Physik und Biophysik, Universitat Leipzig, Leipzig, D 04103, Germany
    Biochemistry (Mosc) 69:4-9. 2004
  9. ncbi Activated neutrophils inhibit nucleotide excision repair in human pulmonary epithelial cells: role of myeloperoxidase
    Nejla Güngör
    Department of Health Risk Analysis and Toxicology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    FASEB J 21:2359-67. 2007
  10. ncbi Genetic polymorphisms of MPO, COMT, MnSOD, NQO1, interactions with environmental exposures and bladder cancer risk
    Rayjean J Hung
    International Agency of Research on Cancer, Lyon 69008, France
    Carcinogenesis 25:973-8. 2004

Detail Information

Publications257 found, 100 shown here

  1. ncbi [Disturbed neutrophil activation in pneumonia during medicinal immunosuppression]
    J Braun
    Medizinische Klinik II,
    Pneumologie 51:1037-42. 1997
    ..In addition to the cell differential the BALF concentrations of the neutrophil degranulation products myeloperoxidase (MPO) and lactoferrin were determined using immunoluminometric assays...
  2. ncbi Myeloperoxidase G-463A polymorphism and Alzheimer's disease in the ApoEurope study
    Brigitte Leininger-Muller
    INSERM Unite 525, Centre de Médecine Préventive and Faculté de Pharmacie, Nancy, France
    Neurosci Lett 349:95-8. 2003
    ..A polymorphism in the myeloperoxidase gene (MPO) has previously been associated with AD susceptibility...
  3. pmc Elevated plasma free fatty acids increase cardiovascular risk by inducing plasma biomarkers of endothelial activation, myeloperoxidase and PAI-1 in healthy subjects
    Manoj Mathew
    Diabetes Division, Department of Medicine, The University of Texas Health Science Center at San Antonio, Texas 78229, USA
    Cardiovasc Diabetol 9:9. 2010
    ..We examined the contribution of FFA to these abnormalities following a 48-hour physiological increase in plasma FFA to levels of obesity and diabetes in a group of healthy subjects...
  4. ncbi Myeloperoxidase inactivates TIMP-1 by oxidizing its N-terminal cysteine residue: an oxidative mechanism for regulating proteolysis during inflammation
    Yi Wang
    Department of Medicine, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington 98195, USA
    J Biol Chem 282:31826-34. 2007
    ..the interaction of TIMPs with MMPs might involve hypochlorous acid (HOCl), a potent oxidant produced by the myeloperoxidase (MPO) system of phagocytes...
  5. ncbi Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase
    Stephan Baldus
    Department of Cardiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Circulation 113:1871-8. 2006
    Neutrophils and monocytes are centrally linked to vascular inflammatory disease, and leukocyte-derived myeloperoxidase (MPO) has emerged as an important mechanistic participant in impaired vasomotor function...
  6. pmc Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer disease
    Richard A Maki
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    J Biol Chem 284:3158-69. 2009
    b>Myeloperoxidase (MPO) is expressed in Alzheimer disease (AD) but not normal aged brain. A functional -463G/A MPO promoter polymorphism has been associated with AD risk through as yet unidentified mechanisms...
  7. ncbi Genetic polymorphism in myeloperoxidase but not GSTM1 is associated with risk of lung squamous cell carcinoma in a Chinese population
    Wenfu Lu
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100 021, China
    Int J Cancer 102:275-9. 2002
    b>Myeloperoxidase (MPO), an enzyme derived from neutrophils, metabolically activates a wide range of carcinogens, whereas glutathione S-transferase M1 (GSTM1) detoxifies various electrophilic metabolites...
  8. ncbi Properties, functions, and secretion of human myeloperoxidase
    J Arnhold
    Institut fur Medizinische Physik und Biophysik, Universitat Leipzig, Leipzig, D 04103, Germany
    Biochemistry (Mosc) 69:4-9. 2004
    The heme-containing protein myeloperoxidase is released from stimulated polymorphonuclear leukocytes at sites of inflammation. It is involved in the generation of reactive oxygen and nitrogen species and tissue damage...
  9. ncbi Activated neutrophils inhibit nucleotide excision repair in human pulmonary epithelial cells: role of myeloperoxidase
    Nejla Güngör
    Department of Health Risk Analysis and Toxicology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    FASEB J 21:2359-67. 2007
    ..and we observed a significant reduction of NER in the A549 cells, which was abrogated by addition of the myeloperoxidase (MPO) inhibitor 4-aminobenzoic acid hydrazide...
  10. ncbi Genetic polymorphisms of MPO, COMT, MnSOD, NQO1, interactions with environmental exposures and bladder cancer risk
    Rayjean J Hung
    International Agency of Research on Cancer, Lyon 69008, France
    Carcinogenesis 25:973-8. 2004
    ..Several enzymes, which play key roles in oxidative stress are polymorphic in humans. Myeloperoxidase (MPO) produces a strong oxidant for microbicidal activity, and activates carcinogens in tobacco smoke...
  11. ncbi Myeloperoxidase mediates cell adhesion via the alpha M beta 2 integrin (Mac-1, CD11b/CD18)
    M W Johansson
    Department of Physiological Botany, University of Uppsala, Villavagen 6, Sweden
    J Cell Sci 110:1133-9. 1997
    b>Myeloperoxidase is a leukocyte component able to generate potent microbicidal substances. A homologous invertebrate blood cell protein, peroxinectin, is not only a peroxidase but also a cell adhesion ligand...
  12. ncbi Combined effects of genetic polymorphisms in six selected genes on lung cancer susceptibility
    Mihi Yang
    Department of Toxicology, College of Pharmacy, Sookmyung Women s University, 53 12 Chungpa Dong, Yongsan gu, Seoul 140 742, Republic of Korea
    Lung Cancer 57:135-42. 2007
    ..Particularly, genetic polymorphisms in NAD(P)H-quinone oxidoreductase (NQO1), cytochrome P450 (CYP)1A1, myeloperoxidase (MPO), glutathione-S-transferase (GST)P1, GSTT1, and GSTM1, and have been suspected to affect lung cancer ..
  13. ncbi Point: myeloperoxidase -463G --> a polymorphism and lung cancer risk
    Anne Feyler
    Unit of Cancer Epidemiology INSERM U521, Gustave Roussy Institute, 94805 Villejuif, France
    Cancer Epidemiol Biomarkers Prev 11:1550-4. 2002
    b>Myeloperoxidase (MPO) is released from neutrophils in lung tissue in response to exposure to various pulmonary insults, including tobacco smoking...
  14. pmc Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis
    Sander S Rensen
    Department of Surgery, Maastricht University Medical Centre, PO Box 616, Maastricht 6200 MD, The Netherlands
    Am J Pathol 175:1473-82. 2009
    ..b>Myeloperoxidase (MPO) is an important neutrophil enzyme that can generate aggressive oxidants; therefore, we studied the ..
  15. pmc Myeloperoxidase: a front-line defender against phagocytosed microorganisms
    Seymour J Klebanoff
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Leukoc Biol 93:185-98. 2013
    ....
  16. doi Oxidative stress-related genotypes, fruit and vegetable consumption and breast cancer risk
    Yulin Li
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Carcinogenesis 30:777-84. 2009
    ..Genetic variations in catalase (CAT) (C-262T), myeloperoxidase (MPO) (G-463A), endothelial nitric oxide synthase (NOS3) (G894T) and heme oxygenase-1 (HO-1) [(GT)(n) ..
  17. ncbi [Gene polymorphism of myeloperoxidase and genetic susceptibility to lung cancer]
    Xiao Ming Wu
    Institute of Environmental Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, PR China
    Ai Zheng 22:912-5. 2003
    A-463 bp G/A polymorphism is located in the promoter region of myeloperoxidase (MPO) gene was found to be associated with lung cancer susceptibility; however, this association in Chinese population remained unclear...
  18. ncbi [Lung cancer risk associated with genetic polymorphism in myeloperoxidase (-463 G/A) in a Chinese population]
    Wenfu Lu
    Cancer Institute Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China
    Zhonghua Zhong Liu Za Zhi 24:250-3. 2002
    ..between susceptibility to lung cancer among Chinese and genetic polymorphism at nucleotide -463 (G/A) in myeloperoxidase (MPO), an enzyme found in lysosomes of phagocytes and involved in the formation of hydroxyl radicals and ..
  19. ncbi Myeloperoxidase G-463A polymorphism and lung cancer: a HuGE genetic susceptibility to environmental carcinogens pooled analysis
    Emanuela Taioli
    University of Pittsburgh, Cancer Institute, Pittsburgh, Pensylvania 15232, USA
    Genet Med 9:67-73. 2007
    b>Myeloperoxidase is a phase I metabolic enzyme that converts the metabolites of benzo[a]pyrene from tobacco smoke into highly reactive epoxides...
  20. doi [A meta analysis on the relationship between myeloperoxidase G-463A genetic polymorphisms and lung cancer susceptibility]
    Feng Hua
    Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenviroment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China
    Zhongguo Fei Ai Za Zhi 13:122-7. 2010
    The relationship between myeloperoxidase G-463A genetic polymorphisms and lung cancer susceptibility has been studied extensively. However, the outcomes are not consistent...
  21. ncbi Increased myeloperoxidase and lipid peroxide-modified protein in gynecological malignancies
    M Song
    Department of Gynecology and Obstetrics, Emory University, School of Medicine, Atlanta, GA 30322, USA
    Antioxid Redox Signal 3:1139-46. 2001
    ..In this study, we measured the levels of myeloperoxidase (MPO), an enzyme associated with oxidation and autoantibodies to lipid peroxide-modified protein (LOOH-RSA), ..
  22. ncbi Myeloperoxidase -463 (G-->A) polymorphism associated with lower risk of lung cancer
    Orhun H Kantarci
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 77:17-22. 2002
    To study the association of the myeloperoxidase (MPO) -463 (G-->A) polymorphism with lung cancer risk.
  23. ncbi Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte colony-stimulating factor
    K Morishita
    Institute of Medical Science, University of Tokyo, Japan
    J Biol Chem 262:15208-13. 1987
    By using the full-length cDNA as a probe, the chromosomal gene for human myeloperoxidase was isolated from a human gene library...
  24. doi Myeloperoxidase and paraoxonase-1 in type 2 diabetic patients
    F R Jornayvaz
    Service of Endocrinology, Diabetes and Nutrition, Department of Internal Medicine, Faculty of Medicine, Geneva University, Geneva, Switzerland
    Nutr Metab Cardiovasc Dis 19:613-9. 2009
    Reduced high density lipoproteins (HDL) and increased oxidative stress are features of type 2 diabetes. Myeloperoxidase is an oxidative enzyme partly associated with HDL and causing HDL dysfunction...
  25. ncbi Myeloperoxidase-dependent caspase-3 activation and apoptosis in HL-60 cells: protection by the antioxidants ascorbate and (dihydro)lipoic acid
    Melinda C Myzak
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 6512, USA
    Redox Rep 7:47-53. 2002
    The heme enzyme myeloperoxidase (MPO) has recently been implicated in hydrogen peroxide H(2)O(2)-induced apoptosis of HL-60 human leukemia cells...
  26. doi Elevated levels of myeloperoxidase, white blood cell count and 3-chlorotyrosine in Taiwanese patients with acute myocardial infarction
    Mei Ling Cheng
    Graduate Institute of Medical Biotechnology and Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    Clin Biochem 41:554-60. 2008
    ..risk factor for acute myocardial infarction (AMI), is associated with leukocytic activation, secretion of myeloperoxidase (MPO) and generation of the oxidative damage marker, 3-chlorotyrosine (3-Cl-Tyr)...
  27. ncbi X-ray crystal structure of canine myeloperoxidase at 3 A resolution
    J Zeng
    Department of Biochemistry and Molecular Biology, University of Miami Medical School, FL 33101
    J Mol Biol 226:185-207. 1992
    The three-dimensional structure of the enzyme myeloperoxidase has been determined by X-ray crystallography to 3 A resolution...
  28. doi Oxidative stress and myeloperoxidase activity during bacterial meningitis: effects of febrile episodes and the BBB permeability
    Dijana Miric
    Institute of Biochemistry, Medical Faculty Pristina Kosovska Mirtovica, Anri Dinana bb, 38220, Kosovska Mitrovica, Serbia
    Clin Biochem 43:246-52. 2010
    To investigate participation of extracellular myeloperoxidase (MPO) in oxidative stress during different courses of the bacterial meningitis (BM).
  29. ncbi Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer risk
    Jiyoung Ahn
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Cancer Res 64:7634-9. 2004
    b>Myeloperoxidase (MPO), an antimicrobial enzyme in the breast, generates reactive oxygen species (ROS) endogenously...
  30. ncbi Glutathione S-transferase P1 and NADPH quinone oxidoreductase polymorphisms are associated with aberrant promoter methylation of P16(INK4a) and O(6)-methylguanine-DNA methyltransferase in sputum
    Frank D Gilliland
    Keck School of Medicine, Department of Preventive Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089 9021, USA
    Cancer Res 62:2248-52. 2002
    ..functional polymorphic variants of the NADPH quinone oxidoreductase, glutathione S-transferases P1 and M1, myeloperoxidase, and XRCC1 genes are associated with p16 and/or MGMT promoter methylation in sputum from cancer-free subjects ..
  31. ncbi Pathogenic role of myeloperoxidase in acute pancreatitis
    Serge Chooklin
    Department of Surgery, Medical University, Lviv, Ukraine
    Hepatobiliary Pancreat Dis Int 8:627-31. 2009
    b>Myeloperoxidase (MPO) has been implicated in promoting tissue damage in various inflammatory diseases. However, MPO blood levels in relation to the severity of acute pancreatitis (AP) and its time-course have not been studied...
  32. ncbi Reactions of superoxide with myeloperoxidase
    Anthony J Kettle
    Free Radical Research, Department of Pathology, University of Otago Christchurch, P O Box 4345 Christchurch, New Zealand
    Biochemistry 46:4888-97. 2007
    When neutrophils ingest bacteria, they discharge superoxide and myeloperoxidase into phagosomes. Both are essential for killing of the phagocytosed micro-organisms...
  33. pmc Myeloperoxidase genotypes and enhanced efficacy of chemotherapy for early-stage breast cancer in SWOG-8897
    Christine B Ambrosone
    Roswell Park Cancer Institute, Department of Cancer Prevention and Control, Buffalo, NY 14263, USA
    J Clin Oncol 27:4973-9. 2009
    b>Myeloperoxidase (MPO) generates reactive oxygen species and also activates xenobiotics...
  34. pmc Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity
    Kathleen D Metzler
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany
    Blood 117:953-9. 2011
    The granule enzyme myeloperoxidase (MPO) plays an important role in neutrophil antimicrobial responses. However, the severity of immunodeficiency in patients carrying mutations in MPO is variable...
  35. doi Conformational and thermal stability of mature dimeric human myeloperoxidase and a recombinant monomeric form from CHO cells
    Srijib Banerjee
    Division of Biochemistry, Department of Chemistry, Vienna Institute of BioTechnology, BOKU University of Natural Resources and Life Sciences, Vienna, Austria
    Biochim Biophys Acta 1814:375-87. 2011
    b>Myeloperoxidase (MPO) is a lysosomal heme enzyme present in the azurophilic granules of human neutrophils and monocytes. It is a critical element of the human innate immune system by exerting antimicrobial effects...
  36. pmc Essential role of proximal histidine-asparagine interaction in mammalian peroxidases
    Xavier Carpena
    Institute of Research in Biomedicine IRB Barcelona, Parc Cientific, Baldiri i Reixac 10, 08028 Barcelona, Spain
    J Biol Chem 284:25929-37. 2009
    ..The crystal structure of a mixture of glycoforms of myeloperoxidase (MPO) purified from granules of human leukocytes prompted us to revise the orientation of this asparagine and ..
  37. ncbi Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway
    Halla Skuladottir
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark
    Lung Cancer 48:187-99. 2005
    ..The effect modification was generally strongest at lower levels of smoking...
  38. doi A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers
    Shanbeh Zienolddiny
    Section of Toxicology, Department of Biological and Chemical Work Environment, National Institute of Occupational Health N 0033, Oslo, Norway
    Carcinogenesis 29:1164-9. 2008
    ..However, only four of the previously reported associations with polymorphisms in the GSTP1 (Ala14Val), SOD2 (Val16Ala), EPHX1 (His139Arg) genes and the NAT1 fast acetylator phenotype remained significantly associated with lung cancer...
  39. ncbi Genetic variants of myeloperoxidase and catechol-O-methyltransferase and breast cancer risk
    S C Lin
    School of Public Health, National Defense Medical Center, No 161, Section 6 Min Chuan East Road, Taipei 114, Taiwan, Republic of China
    Eur J Cancer Prev 14:257-61. 2005
    This nested case-control study evaluated the role of polymorphisms in the myeloperoxidase (MPO) and catechol-O-methyltransferase (COMT) genes that modulate oxidative stress in breast cancer risk in a Chinese population...
  40. doi Human myeloperoxidase in innate and acquired immunity
    Juergen Arnhold
    Institute for Medical Physics and Biophysics, Medical Faculty, University of Leipzig, Leipzig, Germany
    Arch Biochem Biophys 500:92-106. 2010
    ..One of the key components of PMNs is the heme-containing enzyme myeloperoxidase (MPO) that is stored in large amount in azurophilic granules of resting cells...
  41. ncbi Polymorphisms in manganese superoxide dismutase, myeloperoxidase and glutathione-S-transferase and survival after treatment for metastatic breast cancer
    Mary A Bewick
    Sudbury Regional Hospital, Regional Cancer Center, 41 Ramsey Lake Rd, Sudbury, ON, Canada, P3E 5J1
    Breast Cancer Res Treat 111:93-101. 2008
    ..005 and 0.006 for PFS and BCSS, respectively. These results suggest that SNPs in genes involved in drug metabolism may influence survival outcome for patients with MBC receiving HDC and ASCT...
  42. ncbi A myeloperoxidase polymorphism associated with reduced risk of lung cancer
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Box 189, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Lung Cancer 37:35-40. 2002
    b>Myeloperoxidase (MPO) is a metabolic/oxidative enzyme found in neutrophils and monocytes that contributes to pulmonary carcinogenesis through activation of specific procarcinogens including benzo[a]pyrene intermediates, 4-aminobiphenyl ..
  43. doi Myeloperoxidase delays neutrophil apoptosis through CD11b/CD18 integrins and prolongs inflammation
    Driss El Kebir
    Research Center, Maisonneuve Rosemont Hospital, University of Montreal, 5415 blvd de l Assomption, Montreal, QC, Canada H1T 2M4
    Circ Res 103:352-9. 2008
    ..b>Myeloperoxidase (MPO), a heme protein abundantly expressed in neutrophils, is generally associated with killing of bacteria ..
  44. ncbi Polymorphisms in DNA repair genes, chromosome aberrations, and lung cancer
    Carsten Harms
    Center of Environmental Research and Technology, Laboratory of Bioanalytic, UFT, University of Bremen, Bremen, Germany
    Environ Mol Mutagen 44:74-82. 2004
    ..The observation that patients had significantly increased CA frequencies compared with controls, irrespective of genotype, suggests that patients have additional factors that contribute to the development of lung cancer...
  45. ncbi CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung
    Jill Everland Larsen
    Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Australia
    Carcinogenesis 27:525-32. 2006
    ..Candidates include genetic variants of glutathione S-transferases (GSTM1, GSTT1 and GSTP1) and myeloperoxidase (MPO)...
  46. doi The MPO -463G>A polymorphism and cancer risk: a meta-analysis based on 43 case-control studies
    Haiyan Chu
    Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
    Mutagenesis 25:389-95. 2010
    b>Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species and plays an important role in the aetiology of cancer...
  47. ncbi Redox properties of the couples compound I/compound II and compound II/native enzyme of human myeloperoxidase
    Paul Georg Furtmüller
    Institute of Chemistry, Metalloprotein Research Group, University of Agricultural Sciences, Muthgasse 18, A 1190 Vienna, Austria
    Biochem Biophys Res Commun 301:551-7. 2003
    b>Myeloperoxidase (MPO) is an important component of the neutrophil's antimicrobial armory and has been implicated in promoting tissue damage in numerous inflammatory diseases...
  48. ncbi Myeloperoxidase: new polymorphisms and relation with lung cancer risk
    Isabelle Chevrier
    UMRS INSERM 490, Molecular Toxicology, Faculté des Saints Pères, Paris, France
    Pharmacogenetics 13:729-39. 2003
    b>Myeloperoxidase (MPO) is an haemoprotein that metabolizes tobacco smoke procarcinogens such as benzo(a)pyrene and aromatic amines into highly reactive intermediates...
  49. doi Arterial stiffness, carotid artery intima-media thickness and plasma myeloperoxidase level in children with type 1 diabetes
    Kaire Heilman
    Department of Paediatrics, University of Tartu, Tartu, Estonia
    Diabetes Res Clin Pract 84:168-73. 2009
    The present study investigated the functional-structural changes of the arteries along with a new biochemical marker of atherosclerosis, plasma myeloperoxidase level, in children with type 1 diabetes (T1DM).
  50. ncbi Human myeloperoxidase: structure of a cyanide complex and its interaction with bromide and thiocyanate substrates at 1.9 A resolution
    M Blair-Johnson
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Biochemistry 40:13990-7. 2001
    The 1.9 A X-ray crystal structure of human myeloperoxidase complexed with cyanide (R = 0.175, R(free) = 0...
  51. ncbi Killing activity of neutrophils is mediated through activation of proteases by K+ flux
    Emer P Reeves
    Centre for Molecular Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
    Nature 416:291-7. 2002
    ..by subjecting them to high concentrations of highly toxic reactive oxygen species (ROS) and bringing about myeloperoxidase-catalysed halogenation...
  52. ncbi Myeloperoxidase enhances nitric oxide catabolism during myocardial ischemia and reperfusion
    Stephan Baldus
    Department of Cardiology, University Hospital Hamburg Eppendorf, 20246 Hamburg, Germany
    Free Radic Biol Med 37:902-11. 2004
    ..Whereas myeloperoxidase (MPO), a highly abundant, PMN-derived heme protein facilitates oxidative NO consumption and impairs vascular ..
  53. ncbi Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the -463GA promoter polymorphism
    Alan P Kumar
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    J Biol Chem 279:8300-15. 2004
    A functional myeloperoxidase (MPO) promoter polymorphism, -463GA, has been associated with incidence or severity of inflammatory diseases, including atherosclerosis and Alzheimer's disease, and some cancers...
  54. ncbi Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes
    Stephan Baldus
    University of Hamburg, Department of Cardiology, Martinistrasse 52, 20246 Hamburg, Germany
    Circulation 108:1440-5. 2003
    ..b>Myeloperoxidase (MPO), a hemoprotein abundantly expressed by PMNs and secreted during activation, possesses potent ..
  55. ncbi Myeloperoxidase polymorphism related to cardiovascular events in coronary artery disease
    Folkert W Asselbergs
    Am J Med 116:429-30. 2004
  56. doi Enzyme levels and G-463A polymorphism of myeloperoxidase in chronic lymphocytic leukemia and multiple myeloma
    Eyup Ilker Saygili
    Vocational School of Higher Education for Health Services, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey
    Leuk Lymphoma 50:2030-7. 2009
    The aim of this study was to investigate how myeloperoxidase (MPO) G-463A gene polymorphism and enzyme levels varied among patients with chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) and to find the relationship between ..
  57. ncbi Analyses of bulky DNA adduct levels in human breast tissue and genetic polymorphisms of cytochromes P450 (CYPs), myeloperoxidase (MPO), quinone oxidoreductase (NQO1), and glutathione S-transferases (GSTs)
    Ulrike Brockstedt
    Division of Hemato Oncology, Charles Bruneau Cancer Center, Sainte Justine Hospital, University of Montreal, 3175 Cote Sainte Catherine, Que, Canada H3T 1C5
    Mutat Res 516:41-7. 2002
    ..When the MPO and GSTP1 were examined together, individuals with these combined variant genotypes had significantly higher adduct levels than all other genotype combinations (P=0.003)...
  58. ncbi A genotypic association implicates myeloperoxidase in the progression of hepatic fibrosis in chronic hepatitis C virus infection
    W F Reynolds
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Genes Immun 3:345-9. 2002
    ..cells heavily represented in the inflammatory cell response, contain the oxidant generating enzyme myeloperoxidase (MPO)...
  59. doi Myeloperoxidase G-463A polymorphism and risk of lung and prostate cancer in a Turkish population
    Serdal Arslan
    Department of Molecular Biology and Genetics, Faculty of Science, Cumhuriyet University, 58140 Sivas, Turkey
    Mol Med Rep 4:87-92. 2011
    b>Myeloperoxidase (MPO) is a phase I enzyme that can bioactivate many specific procarcinogens, including polycyclic aromatic hydrocarbons and aromatic amines...
  60. doi Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer
    Maria Timofeeva
    Department of Epigenomics and Cancer Risk Factors, German Cancer Research Centre DKFZ, Heidelberg, Germany
    Int J Cancer 127:1547-61. 2010
    ..To confirm these observations and to eliminate possible bias in our analyses, larger studies are warranted...
  61. doi Myeloperoxidase overexpression in children with hypercholesterolemia
    P Pignatelli
    Division of Internal Medicine H, La Sapienza University of Rome, Italy
    Atherosclerosis 205:239-43. 2009
    ..No data have been reported concerning the behavior of age-related oxidative stress in hypercholesterolemic children...
  62. ncbi Myeloperoxidase -463G>A polymorphism and risk of primary lung cancer in a Korean population
    Jae Hyung Park
    Department of Internal Medicine, Kyungpook National University Hospital, Samduk 2Ga 50, Daegu 700 412, South Korea
    Cancer Detect Prev 30:257-61. 2006
    b>Myeloperoxidase (MPO) contributes to pulmonary carcinogenesis through activation of a wide range of tobacco smoke procarcinogens, including benzo[a]pyrene and aromatic amines...
  63. ncbi Myeloperoxidase promotor polymorphism and risk of hepatoblastoma
    Samart Pakakasama
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Int J Cancer 106:205-7. 2003
    b>Myeloperoxidase (MPO) is a major enzyme found in neutrophils. Oxidation by MPO produces free radicals that demonstrate genotoxic properties...
  64. ncbi Polymorphisms in genes related to oxidative stress (CAT, MnSOD, MPO, and eNOS) and acute toxicities from radiation therapy following lumpectomy for breast cancer
    Jiyoung Ahn
    Division of Cancer Prevention and Population Science, Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Cancer Res 12:7063-70. 2006
    ..via generation of massive oxidative stress, we hypothesized that catalase, manganese superoxide dismutase, myeloperoxidase (MPO), and endothelial nitric oxide synthase (eNOS) genotypes might result in greater risk of radiotoxicity.
  65. ncbi MPO and APOEepsilon4 polymorphisms interact to increase risk for AD in Finnish males
    W F Reynolds
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Neurology 55:1284-90. 2000
    b>Myeloperoxidase (MPO) is present in senile plaques and surrounding reactive microglia, but not in normal brain parenchyma. MPO in plaques is highest in APOE epsilon4 carriers, suggesting a functional interaction...
  66. ncbi Nitric oxide is a physiological substrate for mammalian peroxidases
    H M Abu-Soud
    Department of Cell Biology and Department of Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 275:37524-32. 2000
    ..b>Myeloperoxidase (MPO), eosinophil peroxidase, and lactoperoxidase all catalytically consumed NO in the presence of the co-..
  67. doi Effect of combined genetic polymorphisms on lung cancer risk in northern Thai women
    Jaewwaew Klinchid
    Division of Clinical Chemistry, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand
    Cancer Genet Cytogenet 195:143-9. 2009
    ..Confirmation would require further investigations with larger sample sizes...
  68. ncbi Gender and smoking-related risk reduction of periodontal disease with variant myeloperoxidase alleles
    P Meisel
    Department of Pharmacology, Ernst Moritz Arndt University Greifswald, Germany
    Genes Immun 3:102-6. 2002
    b>Myeloperoxidase (MPO) is an oxidative enzyme expressed in polymorphonuclear leukocytes. It is involved in the defence against periodontal bacteria, and is also able to mediate inflammatory tissue destruction in periodontal disease...
  69. ncbi CYP1B1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women
    Kyong Ah Yoon
    Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, South Korea
    Lung Cancer 60:40-6. 2008
    ....
  70. ncbi Variation in the promoter region of the myeloperoxidase gene is not directly related to lung cancer risk among male smokers in Finland
    R R Misra
    Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, 6006 Executive Boulevard, Suite 321, Bethesda, MD 20892 7058, USA
    Cancer Lett 164:161-7. 2001
    In order to examine whether a polymorphism in the promoter region of the myeloperoxidase (MPO) gene is associated with lung cancer among male smokers, we conducted a case-control study nested within a Finnish clinical trial cohort...
  71. ncbi Myeloperoxidase (MPO) -463G->A reduces MPO activity and DNA adduct levels in bronchoalveolar lavages of smokers
    Frederik J Van Schooten
    Department of Health Risk Analysis and Toxicology, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 13:828-33. 2004
    The myeloperoxidase (MPO) -463G-->A genetic polymorphism is associated with a reduced risk for lung cancer, but the underlying mechanism is not yet elucidated...
  72. pmc A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk
    Chunyan He
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Breast Cancer Res Treat 113:585-94. 2009
    Oxidative stress may be involved in breast carcinogenesis. Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species (ROS)...
  73. doi Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis
    Pierre Nahon
    Service d Hepatologie, Hopital Jean Verdier, AP HP, Bondy, France
    Hepatology 50:1484-93. 2009
    ..formation in hepatocyte mitochondria and by reduced nicotinamide adenine dinucleotide phosphate oxidases and myeloperoxidase (MPO) in Kupffer cells and liver-infiltrating neutrophils...
  74. ncbi Myeloperoxidase (MPO) genotype and lung cancer histologic types: the MPO -463 A allele is associated with reduced risk for small cell lung cancer in smokers
    Heike Dally
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 102:530-5. 2002
    ..We confirm that the MPO -463 A variant affords a protective effect against lung cancer risk in smokers, which was strongest for SCLC patients...
  75. doi Functional polymorphism of the myeloperoxidase gene in hypertensive nephrosclerosis dialysis patients
    Kent Doi
    Department of Nephrology and Endocrinology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Hypertens Res 30:1193-8. 2007
    b>Myeloperoxidase (MPO) may play an important role not only in host defense reactions but also in local inflammations, especially in atherosclerotic diseases such as hypertensive nephrosclerosis (HN)...
  76. ncbi Genetic variants in SOD2, MPO, and NQO1, and risk of ovarian cancer
    S H Olson
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Gynecol Oncol 93:615-20. 2004
    ..Since the genes superoxide dismutase (SOD2), myeloperoxidase (MPO), and NAD(P)H:quinone oxidoreductase 1 (NQO1) are involved in inflammation and oxidative stress, we ..
  77. ncbi Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer
    Christine B Ambrosone
    Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Res 65:1105-11. 2005
    ..dismutase catalyzes conversion of superoxide radicals to H(2)O(2), with catalase neutralizing H(2)O(2) and myeloperoxidase converting H(2)O(2) to highly reactive hypochlorous acid, we hypothesized that gene variants could impact the ..
  78. pmc Glycosylation pattern of mature dimeric leukocyte and recombinant monomeric myeloperoxidase: glycosylation is required for optimal enzymatic activity
    Pierre Van Antwerpen
    Laboratory of Pharmaceutical Chemistry and the Analytical Platform of Institute of Pharmacy, UniversitéLibre de Bruxelles, Brussels, Belgium
    J Biol Chem 285:16351-9. 2010
    The involvement of myeloperoxidase (MPO) in various inflammatory conditions has been the scope of many recent studies...
  79. ncbi Polymorphisms of the GSTM1, GSTP1, MPO, XRCC1, and NQO1 genes in Chinese patients with non-small cell lung cancers: relationship with aberrant promoter methylation of the CDKN2A and RARB genes
    Eunice C Chan
    University Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, China
    Cancer Genet Cytogenet 162:10-20. 2005
    ..at polymorphic sites of the glutathione S-transferase (GST) M1 (null/wildtype) and P1 (nucleotide 2627 A/G), myeloperoxidase (MPO) (nucleotide -463 G/A), X-ray repair cross-complementing group 1 (XRCC1) (nucleotides 26304 C/T; 28152 G/..
  80. ncbi Increased risk for Alzheimer disease with the interaction of MPO and A2M polymorphisms
    Mario Zappia
    Institute of Neurology, University Magna Graecia, Catanzaro, Italy
    Arch Neurol 61:341-4. 2004
    The genes encoding myeloperoxidase (MPO) and alpha(2)-macroglobulin (A2M) are involved in molecular pathways leading to beta-amyloid deposition...
  81. ncbi Myeloperoxidase genetic polymorphisms modulate human neutrophil enzyme activity: genetic determinants for atherosclerosis?
    Isabelle Chevrier
    Universite Paris Descartes, Faculte de Medecine, INSERM UMRS 490, 45 Rue des Saints Peres, 75270 Paris Cedex 06, France
    Atherosclerosis 188:150-4. 2006
    b>Myeloperoxidase (MPO), an abundant leukocyte hemoprotein has been linked to atherosclerosis and cardiovascular disease. We previously found new genetic polymorphisms in MPO gene...
  82. pmc Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan
    Martin D Rees
    The Heart Research Institute, 114 Pyrmont Bridge Rd Camperdown, Sydney NSW, Australia
    Matrix Biol 29:63-73. 2010
    The potent oxidants hypochlorous acid (HOCl) and hypobromous acid (HOBr) are produced extracellularly by myeloperoxidase, following release of this enzyme from activated leukocytes...
  83. ncbi Counterpoint: the myeloperoxidase -463G-->a polymorphism does not decrease lung cancer susceptibility in Caucasians
    Li Lian Xu
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1555-9. 2002
    The myeloperoxidase (MPO) G-to-A substitution polymorphism in the promoter region of the MPO gene has been associated with a 40-70% reduction in lung cancer risk in several studies, although a recent nested case-control study disputes ..
  84. ncbi Association between asbestos exposure, cigarette smoking, myeloperoxidase (MPO) genotypes, and lung cancer risk
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Holcombe Blvd, Houston, Texas 77303, USA
    Am J Ind Med 42:29-37. 2002
    As observed in tobacco-associated carcinogenesis, genetic factors such as the polymorphic metabolic/oxidative enzyme myeloperoxidase (MPO) could modulate individual susceptibility to asbestos-associated carcinogenesis.
  85. ncbi Myeloperoxidase impairs ABCA1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein A-I
    Baohai Shao
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 281:9001-4. 2006
    ..b>Myeloperoxidase (MPO) is the only known source of 3-chlorotyrosine in vivo, indicating that MPO oxidizes HDL in humans...
  86. pmc Menopausal status modifies breast cancer risk associated with the myeloperoxidase (MPO) G463A polymorphism in Caucasian women: a meta-analysis
    Noel Pabalan
    School of Natural Sciences, Saint Louis University, Baguio City, Philippines
    PLoS ONE 7:e32389. 2012
    ..cancer susceptibility may be modulated partly through polymorphisms in oxidative enzymes, one of which is myeloperoxidase (MPO)...
  87. ncbi Unique autolytic cleavage of human myeloperoxidase. Implications for the involvement of active site MET409
    K L Taylor
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 3050
    J Biol Chem 267:25282-8. 1992
    b>Myeloperoxidase (MPO) is a functionally important component of the normal human neutrophil host defense system...
  88. ncbi Relationships between polymorphisms in NOS3 and MPO genes, cigarette smoking and risk of post-menopausal breast cancer
    Jun Yang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 28:1247-53. 2007
    NOS3 and MPO genes encode endothelial nitric oxide synthase and myeloperoxidase (MPO), respectively, which generate nitric oxide and reactive oxygen species...
  89. ncbi X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8 A resolution
    T J Fiedler
    Department of Biochemistry and Molecular Biology, University of Miami Medical School, Miami, Florida 33136, USA
    J Biol Chem 275:11964-71. 2000
    The x-ray crystal structure of human myeloperoxidase has been extended to 1.8 A resolution, using x-ray data recorded at -180 degrees C (r = 0.197, free r = 0.239)...
  90. ncbi MPO and SOD2 polymorphisms, gender, and the risk of non-small cell lung carcinoma
    Geoffrey Liu
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Lett 214:69-79. 2004
    Manganese superoxide dismutase (SOD2) and myeloperoxidase (MPO) are polymorphic enzymes involved in reactive oxidative species metabolism...
  91. ncbi Myeloperoxidase, a leukocyte-derived vascular NO oxidase
    Jason P Eiserich
    Department of Internal Medicine, Division of Nephrology, University of California, Davis, CA 95616, USA
    Science 296:2391-4. 2002
    b>Myeloperoxidase (MPO) is an abundant mammalian phagocyte hemoprotein thought to primarily mediate host defense reactions...
  92. doi Association of the polymorphisms of MTHFR C677T, VDR C352T, and MPO G463A with risk for esophageal squamous cell dysplasia and carcinoma
    Daqing Li
    Qilu Hospital, Shandong University, Jinan, China
    Arch Med Res 39:594-600. 2008
    ..samples to evaluate the association of polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T, vitamin D receptor (VDR) C352T, and myeloperoxidase (MPO) G463A genotypes with esophageal squamous cell dysplasia and carcinoma.
  93. ncbi Association between Alzheimer's disease and a functional polymorphism in the Myeloperoxidase gene
    F C Crawford
    Roskamp Institute and the University of South Florida Memory Disorder Clinic, 3515 East Fletcher Avenue, Tampa, Florida 33613, USA
    Exp Neurol 167:456-9. 2001
    A polymorphism in the Myeloperoxidase gene (MPO) has previously been demonstrated to be associated with gender-specific risk in an Alzheimer's Disease (AD) autopsy sample...
  94. ncbi Association of apolipoprotein E and myeloperoxidase genotypes to clinical course of familial and sporadic multiple sclerosis
    B Zakrzewska-Pniewska
    Department of Neurology, The Medical University of Warsaw, 02 097 Warsaw, Banacha 1a, Str, Poland
    Mult Scler 10:266-71. 2004
    The importance of apolipoprotein E (ApoE) and myeloperoxidase (MPO) genotypes in the clinical characteristics of multiple sclerosis (MS) has been recently emphasized...
  95. ncbi Interrogation of heme pocket environment of mammalian peroxidases with diatomic ligands
    H M Abu-Soud
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Biochemistry 40:10747-55. 2001
    Recent studies demonstrate that myeloperoxidase (MPO), eosinophil peroxidase (EPO), and lactoperoxidase (LPO), homologous members of the mammalian peroxidase superfamily, can all serve as catalysts for generating nitric oxide- (nitrogen ..
  96. ncbi Subcellular distribution of urokinase and urokinase receptor in human neutrophils determined by immunoelectron microscopy
    T L Pedersen
    Department of Pathology, Herlev Hospital, University of Copenhagen, Denmark
    Ultrastruct Pathol 24:175-82. 2000
    ..matrix metalloproteinase type-9 (MMP-9) for gelatinase granules, lactoferrin (LF) for specific granules, and myeloperoxidase (MPO) and neutrophil elastase (NE) for primary granules...
  97. ncbi Biochemical and physiological alterations in canine neutrophils separated by lysis or Percoll gradient isolation technologies
    D F Gruber
    Experimental Hematology Department, Armed Forces Radiobiology, Research Institute, Bethesda, Maryland 20814-5145
    Immunopharmacol Immunotoxicol 12:93-104. 1990
    ..Cellular isolation methods did not significantly alter cellular myeloperoxidase (MPO) levels based on comparisons of cellular totals...
  98. pmc Improved survival and reversal of endothelial dysfunction by the 21-aminosteroid, U-74389G in splanchnic ischaemia-reperfusion injury in the rat
    F Squadrito
    Institute of Pharmacology, School of Medicine, University of Messina, Italy
    Br J Pharmacol 115:395-400. 1995
    ..TNF-alpha), white blood cell (WBC) count, mean arterial blood pressure (MAP), plasma malonyladehyde (MAL); myeloperoxidase activity (MPO) and the responsiveness to acetylcholine (ACh 10 nM-10 microM) of aortic rings were ..
  99. ncbi Ameliorative effects of sodium ferulate on experimental colitis and their mechanisms in rats
    Wei Guo Dong
    Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, Hubei Province, China
    World J Gastroenterol 9:2533-8. 2003
    ..To investigate the ameliorative effects of sodium ferulate (SF) on acetic acid-induced colitis and their mechanisms in rats...
  100. ncbi Andalusol, a diterpenoid with anti-inflammatory activity from Siderits foetens Clemen
    A Navarro
    , Facultad de Farmacia, Universidad Complutense de Madrid, Spain
    Z Naturforsch C 52:844-9. 1997
    ..Quantitation of the neutrophil specific marker, myeloperoxidase (MPO), demonstrated that its topical anti-inflammatory effect was associated with reduction in neutrophil ..

Research Grants65

  1. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2012
    ..While generally attributed to the phagocyte-specific enzyme myeloperoxidase (MPO), it is unclear whether a peroxidase other than MPO in vascular wall plays a role in atherogenesis...
  2. Dual Function of VPO1 in Pathogen Recognition and Killing
    Guangjie Cheng; Fiscal Year: 2013
    ....
  3. Mechanisms and Prevention of Etoposide-Induced Leukemia
    Jack C Yalowich; Fiscal Year: 2011
    ..Our central hypothesis is that redox cycling of VP-16 initiated by myeloperoxidase (MPO) found prominently in myeloid precursors amplifies the genotoxicity and carcinogenicity of this ..
  4. Molecular imaging of vascular pathology
    John W Chen; Fiscal Year: 2010
    ....
  5. MPO oxidants in synucleinopathies
    Wanda F Reynolds; Fiscal Year: 2013
    ..Our studies suggest that myeloperoxidase (MPO) is a significant source of oxidants that promote misfolding and aggregation of a-syn, as well as ..
  6. Angiotensin II, oxidative stress and aneurysm formation
    Neal L Weintraub; Fiscal Year: 2013
    ..are capable of inducing vascular oxidant stress and potentially contributing to AAA, we hypothesis that myeloperoxidase (MPO) is instrumental in this process...
  7. CFTR Expression and Function in Human Neutrophils
    Guoshun Wang; Fiscal Year: 2010
    ..main phagocytes responsible for elimination of pathogens and cell debris, synthesize and maintain abundant myeloperoxidase (MPO)...
  8. Human neutrophils, phospholipase A2 and S.aureus: microbial targets and responses
    William M Nauseef; Fiscal Year: 2013
    ..Importantly, hydrogen peroxide (H2O2) produced by PMN is amplified by the PMN granule protein myeloperoxidase (MPO) to generate HOCl (bleach)...
  9. Novel mechanisms of niacin to improve HDL function: Role of myeloperoxidase
    Moti L Kashyap; Fiscal Year: 2013
    ..to understanding the mechanisms for formation of dysfunctional HDL, evidence points to a role for neutrophils myeloperoxidase (MPO)-generated oxidants as participants in rendering HDL dysfunctional...
  10. The role of neutrophil recruitment in arterial diseases
    Yuqing Huo; Fiscal Year: 2013
    ..mice, mice in which the expression of Cre recombinase and EGFP are driven by the regulatory region of the myeloperoxidase (MPO) gene (MPO-Cre mice)...
  11. DNA Repair Capacity and Risk of Pre-malignant Lesion in Lung Epithelium
    Hua Zhao; Fiscal Year: 2009
    ..neutrophils, including induction of oxidative DNA damage through release of reactive oxygen species (ROS) and myeloperoxidase (MPO)-related metabolic activation of chemical carcinogens, is a crucial etiological factor in this ..
  12. The role of neutrophils in SAH
    JOSE JAVIER PROVENCIO; Fiscal Year: 2011
    ..This proposal and the educational components included form the basis for Dr. Provencio to develop into an independent physician-scientist. ..
  13. Characterization of Salmonella typhimurium-induced NET formation
    Josely F Figueiredo; Fiscal Year: 2013
    ..NET formation involves extracellular release of chromatin and associated proteins, such as elastase and myeloperoxidase (MPO), which are released from primary granules...
  14. CRP, Diabetes, Atherothrombosis
    Ishwarlal Jialal; Fiscal Year: 2010
    ..CRP augments oxidative stress and inflammation in the diabetic milieu will eventually lead to therapies targeted at reducing inflammation and oxidative stress in diabetes and resulting in a decrease in vasculopathies ..
  15. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..Inflammatory markers and markers of oxidative stress, including interleukin (IL)-6, -8 and -10, myeloperoxidase (MPO), and matrix metalloproteinase-9 (MMP-9) will be analyzed in induced sputum...
  16. Prevention of UV-induced carcinogenesis by cyanidin-3-glucoside
    Xianglin Shi; Fiscal Year: 2013
    ..These inflammatory mediators include infiltrating leukocytes and myeloperoxidase (MPO), COX-2, PGE2, and several pro-inflammatory cytokines, TNF-1, IL-2, and IL-6. Specific Aim 4...
  17. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    Kirkwood A Pritchard; Fiscal Year: 2013
    ..of HDL and therefore HDL function and if targeting oxidative stress induced by 1) xanthine oxidase (XO);2) myeloperoxidase (MPO);3) cell free hemoglobin (Hb);and, 4) oxidized lipids prevents oxidation of HDL and other lipoproteins ..
  18. Novel Peptide MPO Inhibitors for Treating Atherosclerosis
    Kirkwood A Pritchard; Fiscal Year: 2012
    ..Summary The long-term goal of this application is to optimize the design of novel, non-toxic inhibitors of myeloperoxidase (MPO) to inhibit atherosclerosis...
  19. NEUTROPHIL AUTOANTIBODIES IN VASCULITIS AND NEPHRITIS
    Ronald Falk; Fiscal Year: 2000
    ....
  20. LIPID PEROXIDATION IN COLORECTAL CANCER
    Manuela Gago Dominguez; Fiscal Year: 2009
    ..1. To conduct a family-based case-control association study of oxidative stress-related genes, including myeloperoxidase (MPO), endothelial cell nitric oxide synthase (ecNOS), manganese superoxide dismutase (MnSOD), selenium-..
  21. Plasmalogen-derived bioactive lipids in atherosclerosis
    David A Ford; Fiscal Year: 2013
    ..Levels of myeloperoxidase (MPO) and MPO-derived products have been shown to be elevated in atherosclerotic tissue and potentially ..
  22. ANTI-INFLAMMATORY ACTIVITY OF DAPSONE
    PAULA BOZEMAN; Fiscal Year: 1993
    ..b>Myeloperoxidase (MPO), an enzyme found in the granules of neutrophils and monocytes, catalyzes the oxidation of chloride (Cl-)..
  23. MYLEOPEROXIDASE AND LEUKOCYTE GRANULE COMPONENTS
    EDWIN THOMAS; Fiscal Year: 1992
    Stimulation of neutrophilic leukocytes results in secretion of toxic proteins and the enzyme myeloperoxidase (MPO) from cytoplasmic granules and activates neutrophil oxygen (O2) metabolism, which produces toxic oxidants...
  24. MYELOPEROXIDASE INVOLVEMENT IN ALZHEIMER'S DISEASE
    Wanda Reynolds; Fiscal Year: 2005
    DESCRIPTION (Abstract): Myeloperoxidase (MPO) has been identified as a risk factor for Alzheimer's disease based on the detection of this myeloid-specific enzyme in amyloid plaques, along with Abeta42, and the association of a n463 G/A ..
  25. Development of myeloperoxidase inhibitors to treat atherosclerosis
    RICHARD MAKI; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Myeloperoxidase is recognized as an important causative contributory agent in inflammatory diseases including atherosclerosis...
  26. PARP Inhibitor and Redox Catalyst for Ventilatory Trauma
    Prakash Jagtap; Fiscal Year: 2013
    ..ratio, biochemical markers of redox stress (F2[unreadable]-isoprostane, GSH/GSSG ratio), PMN infiltration (myeloperoxidase;"MPO"), pro-inflammatory protein expression, and immunohistochemical evidence of peroxynitrite-induced 3- ..
  27. Molecular Imaging Probes for Reporting on Vascular Oxidative Response
    Alexei A Bogdanov; Fiscal Year: 2013
    ..b>Myeloperoxidase (MPO, one of the components released by PMNs via triggered exocytosis) is a unique catalytically active ..
  28. Zebrafish Genetics to Identify Genes Involved in Hematopoiesis
    DHVANIT INDRAVADAN SHAH; Fiscal Year: 2013
    ..The appeal and the potential of future outcomes of this project satisfy the objectives of NIDDK sponsored Mentored Scientist Development Award (K01) mechanism. ..
  29. Genes in Human Brain Ischemia
    W Andrew Kofke; Fiscal Year: 2011
    ..Three pathophysiologically based genotypes, apolipoprotein E (ApoE), heat shock protein (HSP), and myeloperoxidase(MPO), all with prior evidence of an effect in vulnerability to brain ischemia, will be evaluated for ..
  30. Biophysics of HDL Dysfunction
    Mary G Sorci-Thomas; Fiscal Year: 2013
    ..anti- and pro-inflammatory enzymes (paraoxonase [PON1], platelet activating factor acetylhydrolase [PAF-AH], myeloperoxidase [MPO] and xanthine oxidase [XO]) to prevent LDL oxidation;2) or ATP binding cassette (ABC) transporter 1 (..
  31. ALTERATION WITH AGE OF RESISTANCE TO EYE INFECTIONS
    Linda D Hazlett; Fiscal Year: 2013
    ..RT-PCR, short interfering RNA (siRNA), as well as plate counts, enzyme linked immunosorbant assay (ELISA), myeloperoxidase assay (MPO) for neutrophil (PMN) quantitation, dual antibody immunostaining, histopathology, and Western ..
  32. Molecular Imaging to Determine the Risk of Rupture of Cerebral Aneurysms
    Alexei Bogdanov; Fiscal Year: 2009
    ..Recent epidemiological evidence suggests that the elevated presence of myeloperoxidase (MPO) in blood is an important risk factor for coronary disease and atherosclerotic plaque rupture...
  33. Myeloperoxidase, imaging biomarker and treatment target for multiple sclerosis
    John W Chen; Fiscal Year: 2013
    ..b>Myeloperoxidase (MPO) is a highly oxidizing enzyme abundantly secreted by active macrophages/microglial cells and certain ..
  34. Evaluation of sensory neuron plasticity following neonatal maternal separation
    JULIE A CARLSTEN CHRISTIANSON; Fiscal Year: 2011
    ..administered to induce colitis and a) the extent of inflammation will be determined by assessing increases in myeloperoxidase (MPO) activity and growth factor production, and b) VMR, single cell RT-PCR and calcium imaging will be ..
  35. Imaging and Treating Inflammation in Stroke by Targeting Myeloperoxidase
    John W Chen; Fiscal Year: 2013
    ..b>Myeloperoxidase (MPO), a highly oxidizing and damaging enzyme secreted by many activated inflammatory cells, is found ..
  36. Regulation of Myeloperoxidase Catalysis by Nitric Oxide
    HUSAM ABU SOUD; Fiscal Year: 2004
    b>Myeloperoxidase (MPO) is abundant hemoprotein present in neutrophils and monocytes which plays an essential role in immune surveillance and host defense mechanisms...
  37. Role of Toll-Like Receptors in Bacterial Keratitis
    Linda D Hazlett; Fiscal Year: 2013
    ..RT-PCR, short interfering RNA (siRNA), as well as plate counts, enyme linked immunosorbant assay (ELISA), myeloperoxidase assay (MPO) for neutrophil (PMN) quantitation, dual antibody immunostaining, histopathology, Tunel assay, DNA ..
  38. Oxidation in Inflammation and Cardiovascular Disease
    Stanley L Hazen; Fiscal Year: 2013
    ..Project 1 focuses on the leukocyte-derived heme protein myeloperoxidase (MPO), an enzyme that can catalytically consume nitric oxide and is a critical participant in oxidative and ..
  39. MPO and NO signaling in neointima formation
    Chunxiang Zhang; Fiscal Year: 2010
    ..b>Myeloperoxidase (MPO) is a leukocyte-derived heme protein...
  40. Myeloperoxidase and NO signaling in the vasculature
    C White; Fiscal Year: 2004
    DESCRIPTION (provided by the applicant): The heme protein myeloperoxidase (MPO) plays an important role in the host defense response...
  41. Quantitative Assessment of HDL Function
    Jay W Heinecke; Fiscal Year: 2013
    ..One involves oxidative damage of apoA-I (the major HDL protein) by myeloperoxidase (MPO). MPO impairs apoA-I's ability to remove cholesterol from macrophages by the ABCA1 pathway...
  42. A TRANSCRIPTIONAL PROGRAM REGULATING MYELOPOIESIS
    Alan Friedman; Fiscal Year: 2004
    ..Myelopoiesis at various levels of C/EBP activity and progenitor fate after various times of C/EBP inhibition will be assessed. ..
  43. Development of Myeloperoxidase Inhibitors to Treat Alzheimer's Disease
    RICHARD ALLAN MAKI; Fiscal Year: 2013
    ..provided by applicant): The overall goal of the proposed research is to develop orally active inhibitors of myeloperoxidase MPO as a treatment forAlzheimer's disease...
  44. EPIDEMIOLOGY OF INFANT LEUKEMIA
    Julie Ross; Fiscal Year: 2007
    ..This study will utilize the unique resources available through the Children's Oncology Group, and include ascertainment of cases over a four-year period (Jan 1, 2003-Dec 31, 2006). ..
  45. MONOCYTE/MACROPHAGE FREE RADICAL BIOLOGY ASSESSED BY EPR
    Bradley Britigan; Fiscal Year: 1993
    ..Even with iron supplementation, PMN lactoferrin and myeloperoxidase (MPO) release inhibited OH generation...
  46. OXIDATIVE NEUTROPHIL MICROBICIDAL MECHANISMS
    Henry Rosen; Fiscal Year: 2000
    ..microbicidal mechanisms of human neutrophils (PMN), especially as they relate to the azurophil granule enzyme myeloperoxidase (MPO)...
  47. Novel MPO-derived plasma lipids as predictors of major adverse coronary events
    David Ford; Fiscal Year: 2009
    ..Elevated plasma myeloperoxidase (MPO) levels have been shown to be a predictor of increased risk of coronary events in patients with acute ..
  48. Interleukin-18 and Intestinal Barrier Function Following Alcohol and Burn Injury
    Mashkoor Choudhry; Fiscal Year: 2007
    ..The increase in IL-18 is accompanied by an increase in intestinal myeloperoxidase (MPO, an index of neutrophil accumulation) activity and intestinal edema...
  49. Predictors of Adult Leukemia
    Julie Ross; Fiscal Year: 2009
    ..The significance of this proposal, specifically with respect-to the identification of possible prevention strategies for adult AML, has important public health implications. ..
  50. Immunogenetics of Non-Hodgkin Lymphoma Survival
    James Cerhan; Fiscal Year: 2006
    ..abstract_text> ..
  51. OXIDATIVE NEUTROPHIL MICROBICIDAL MECHANISMS
    Henry Rosen; Fiscal Year: 1992
    ..systems, the proposed studies will focus on microbicidal properties of a single PMN- derived enzyme, myeloperoxidase (MPO)...
  52. Development of a New Class of Pharmacological Mediators for Myeloperoxidase Inhib
    DESIKAN RAJAGOPAL; Fiscal Year: 2010
    ..This disease is the number one killer around the world, particularly in the United States. Myeloperoxidase (MPO) enzyme has been implicated in many cardiovascular diseases and to date there is no single drug ..
  53. ORGANIZATION OF MALE REPRODUCTIVE NEURAL CIRCUITS
    Anne Murphy; Fiscal Year: 2002
    ..Together, these studies will provide detailed anatomical and physiological data on a neural circuit regulating male sex behavior. ..
  54. Low birth weight & other risk factors for hepatoblastoma
    LOGAN SPECTOR; Fiscal Year: 2009
    ..associations of HB with maternal smoking while pregnant,parental occupation, and a polymorphism in the myeloperoxidase (MPO) gene...
  55. Hypochlorite-Mediated Impairment of Endothelial Function
    John Keaney; Fiscal Year: 2007
    ..There is evidence that two-electron oxidants from myeloperoxidase (MPO), such as HOCl, are important in atherosclerosis and these oxidants would not be sensitive to "classical"..
  56. Oxidation of Apolipoprotein B-100 in LDL
    Chao Yuh Yang; Fiscal Year: 2004
    ..clear differences in products of apoB-1 00 oxidation formed in oxidation of LDL in vitro by Cu2+, HOCl, and myeloperoxidase (MPO)...
  57. MYELOPEROXIDASE-H202-HALIDE SYSTEM IN GLOMERULAR INJURY
    Richard Johnson; Fiscal Year: 1991
    ..We hypothesize that the cationic PMN enzyme myeloperoxidase (MPO) binds on a charge basis to the glomerular capillary wall and catalyzes the reaction of H2O2 with a ..
  58. MR imaging of myeloperoxidase activity
    Ralph Weissleder; Fiscal Year: 2007
    ..inflammation in atherosclerosis by developing and testing novel activatable MR imaging agents that can sense myeloperoxidase (MPO) activity in atheromata...
  59. Determinants of Accelerated CVD in Type 1 Diabetes
    Marian Rewers; Fiscal Year: 2007
    ....
  60. Establishment of new MRI technologies to monitor efficacy of glioma virotherapy
    Giulia Fulci; Fiscal Year: 2009
    ..is inhibited by intratumoral infiltration of phagocytic microglia and peripheral macrophages that present myeloperoxidase (MPO) activity and rapidly clear the injected OVs...
  61. Taurine Chloramine as a Modulator of CNS Inflammation
    Michael Quinn; Fiscal Year: 2004
    Polymorphonuclear leukocytes (PMN, neutrophils) are inflammatory cells that possess halide-dependent myeloperoxidase (MPO). Activated PMN secrete MPO and release it upon death...
  62. Lung Cancer Free Survival Among Aged Smokers
    Agnes Baffoe Bonnie; Fiscal Year: 2002
    ..We will genotype the Myeloperoxidase (MPO) enzyme in probands and first-degree relatives. MPO transforms precarcinogens in tobacco smoke...
  63. Molecular Epidemiology of t-MDS/AML
    Sara Strom; Fiscal Year: 2007
    ..We believe that this study will provide future hypotheses for research into treatment- related malignancies, and may lead to eventual improvements in cancer survivorship. [unreadable] [unreadable] [unreadable]..
  64. ECM Regulation by Estrogen in ARMD
    Sharon Elliot; Fiscal Year: 2006
    ..type IV collagen, may be induced in injured RPE to promote ARMD progression by macrophage-derived oxidants, myeloperoxidase (MPO), as well as macrophage-derived cytokines, especially tumor necrosis factor-alpha (TNF-alpha)...
  65. EXERCISE AND CARDIOVASCULAR DISEASE
    William Weintraub; Fiscal Year: 2003
    ..More importantly, we propose that the activation of oxidative enzymes such as myeloperoxidase (MPO) in the plasma might be an underlying mechanism for such benefits induced by exercise, estrogens, and ..