myeloperoxidase

Summary

Gene Symbol: myeloperoxidase
Description: myeloperoxidase
Alias: myeloperoxidase
Species: human
Products:     myeloperoxidase

Top Publications

  1. Leininger Muller B, Hoy A, Herbeth B, Pfister M, Serot J, Stavljenic Rukavina M, et al. Myeloperoxidase G-463A polymorphism and Alzheimer's disease in the ApoEurope study. Neurosci Lett. 2003;349:95-8 pubmed
    ..A polymorphism in the myeloperoxidase gene (MPO) has previously been associated with AD susceptibility...
  2. Skuladottir H, Autrup H, Autrup J, Tjoenneland A, Overvad K, Ryberg D, et al. Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway. Lung Cancer. 2005;48:187-99 pubmed
    ..The effect modification was generally strongest at lower levels of smoking. ..
  3. Song M, Santanam N. Increased myeloperoxidase and lipid peroxide-modified protein in gynecological malignancies. Antioxid Redox Signal. 2001;3:1139-46 pubmed
    ..In this study, we measured the levels of myeloperoxidase (MPO), an enzyme associated with oxidation and autoantibodies to lipid peroxide-modified protein (LOOH-RSA), ..
  4. Park J, Park J, Kim E, Cha S, Lee E, Kim C, et al. Myeloperoxidase -463G>A polymorphism and risk of primary lung cancer in a Korean population. Cancer Detect Prev. 2006;30:257-61 pubmed
    b>Myeloperoxidase (MPO) contributes to pulmonary carcinogenesis through activation of a wide range of tobacco smoke procarcinogens, including benzo[a]pyrene and aromatic amines...
  5. Nahon P, Sutton A, Rufat P, Ziol M, Akouche H, Laguillier C, et al. Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis. Hepatology. 2009;50:1484-93 pubmed publisher
    ..formation in hepatocyte mitochondria and by reduced nicotinamide adenine dinucleotide phosphate oxidases and myeloperoxidase (MPO) in Kupffer cells and liver-infiltrating neutrophils...
  6. Saygili E, Aksoy N, Pehlivan M, Sever T, Yilmaz M, Cimenci I, et al. Enzyme levels and G-463A polymorphism of myeloperoxidase in chronic lymphocytic leukemia and multiple myeloma. Leuk Lymphoma. 2009;50:2030-7 pubmed publisher
    The aim of this study was to investigate how myeloperoxidase (MPO) G-463A gene polymorphism and enzyme levels varied among patients with chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) and to find the relationship between ..
  7. Shao B, Oda M, Bergt C, Fu X, Green P, Brot N, et al. Myeloperoxidase impairs ABCA1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein A-I. J Biol Chem. 2006;281:9001-4 pubmed
    ..b>Myeloperoxidase (MPO) is the only known source of 3-chlorotyrosine in vivo, indicating that MPO oxidizes HDL in humans...
  8. Yang M, Choi Y, Hwangbo B, Lee J. Combined effects of genetic polymorphisms in six selected genes on lung cancer susceptibility. Lung Cancer. 2007;57:135-42 pubmed
    ..Particularly, genetic polymorphisms in NAD(P)H-quinone oxidoreductase (NQO1), cytochrome P450 (CYP)1A1, myeloperoxidase (MPO), glutathione-S-transferase (GST)P1, GSTT1, and GSTM1, and have been suspected to affect lung cancer ..
  9. Abu Soud H, Hazen S. Nitric oxide is a physiological substrate for mammalian peroxidases. J Biol Chem. 2000;275:37524-32 pubmed
    ..b>Myeloperoxidase (MPO), eosinophil peroxidase, and lactoperoxidase all catalytically consumed NO in the presence of the co-..

More Information

Publications85

  1. Fiedler T, Davey C, Fenna R. X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8 A resolution. J Biol Chem. 2000;275:11964-71 pubmed
    The x-ray crystal structure of human myeloperoxidase has been extended to 1.8 A resolution, using x-ray data recorded at -180 degrees C (r = 0.197, free r = 0.239)...
  2. Taioli E, Benhamou S, Bouchardy C, Cascorbi I, Cajas Salazar N, Dally H, et al. Myeloperoxidase G-463A polymorphism and lung cancer: a HuGE genetic susceptibility to environmental carcinogens pooled analysis. Genet Med. 2007;9:67-73 pubmed
    b>Myeloperoxidase is a phase I metabolic enzyme that converts the metabolites of benzo[a]pyrene from tobacco smoke into highly reactive epoxides...
  3. Baldus S, Heeschen C, Meinertz T, Zeiher A, Eiserich J, Munzel T, et al. Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes. Circulation. 2003;108:1440-5 pubmed
    ..b>Myeloperoxidase (MPO), a hemoprotein abundantly expressed by PMNs and secreted during activation, possesses potent ..
  4. Zakrzewska Pniewska B, Styczynska M, Podlecka A, Samocka R, Peplonska B, Barcikowska M, et al. Association of apolipoprotein E and myeloperoxidase genotypes to clinical course of familial and sporadic multiple sclerosis. Mult Scler. 2004;10:266-71 pubmed
    The importance of apolipoprotein E (ApoE) and myeloperoxidase (MPO) genotypes in the clinical characteristics of multiple sclerosis (MS) has been recently emphasized...
  5. Van Antwerpen P, Slomianny M, Boudjeltia K, Delporte C, Faid V, Calay D, et al. Glycosylation pattern of mature dimeric leukocyte and recombinant monomeric myeloperoxidase: glycosylation is required for optimal enzymatic activity. J Biol Chem. 2010;285:16351-9 pubmed publisher
    The involvement of myeloperoxidase (MPO) in various inflammatory conditions has been the scope of many recent studies...
  6. Klebanoff S, Kettle A, Rosen H, Winterbourn C, Nauseef W. Myeloperoxidase: a front-line defender against phagocytosed microorganisms. J Leukoc Biol. 2013;93:185-98 pubmed publisher
  7. Li D, Diao Y, Li H, Fang X, Li H. Association of the polymorphisms of MTHFR C677T, VDR C352T, and MPO G463A with risk for esophageal squamous cell dysplasia and carcinoma. Arch Med Res. 2008;39:594-600 pubmed publisher
    ..of polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T, vitamin D receptor (VDR) C352T, and myeloperoxidase (MPO) G463A genotypes with esophageal squamous cell dysplasia and carcinoma...
  8. Doi K, Noiri E, Maeda R, Nakao A, Kobayashi S, Tokunaga K, et al. Functional polymorphism of the myeloperoxidase gene in hypertensive nephrosclerosis dialysis patients. Hypertens Res. 2007;30:1193-8 pubmed publisher
    b>Myeloperoxidase (MPO) may play an important role not only in host defense reactions but also in local inflammations, especially in atherosclerotic diseases such as hypertensive nephrosclerosis (HN)...
  9. Chevrier I, Tregouet D, Massonnet Castel S, Beaune P, Loriot M. Myeloperoxidase genetic polymorphisms modulate human neutrophil enzyme activity: genetic determinants for atherosclerosis?. Atherosclerosis. 2006;188:150-4 pubmed
    b>Myeloperoxidase (MPO), an abundant leukocyte hemoprotein has been linked to atherosclerosis and cardiovascular disease. We previously found new genetic polymorphisms in MPO gene...
  10. Arnhold J. Properties, functions, and secretion of human myeloperoxidase. Biochemistry (Mosc). 2004;69:4-9 pubmed
    The heme-containing protein myeloperoxidase is released from stimulated polymorphonuclear leukocytes at sites of inflammation. It is involved in the generation of reactive oxygen and nitrogen species and tissue damage...
  11. Reeves E, Lu H, Jacobs H, Messina C, Bolsover S, Gabella G, et al. Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature. 2002;416:291-7 pubmed
    ..by subjecting them to high concentrations of highly toxic reactive oxygen species (ROS) and bringing about myeloperoxidase-catalysed halogenation...
  12. Liu G, Zhou W, Wang L, Park S, Miller D, Xu L, et al. MPO and SOD2 polymorphisms, gender, and the risk of non-small cell lung carcinoma. Cancer Lett. 2004;214:69-79 pubmed
    Manganese superoxide dismutase (SOD2) and myeloperoxidase (MPO) are polymorphic enzymes involved in reactive oxidative species metabolism...
  13. Güngör N, Godschalk R, Pachen D, Van Schooten F, Knaapen A. Activated neutrophils inhibit nucleotide excision repair in human pulmonary epithelial cells: role of myeloperoxidase. FASEB J. 2007;21:2359-67 pubmed
    ..and we observed a significant reduction of NER in the A549 cells, which was abrogated by addition of the myeloperoxidase (MPO) inhibitor 4-aminobenzoic acid hydrazide...
  14. Cui Z, Zhao M, Segelmark M, Hellmark T. Natural autoantibodies to myeloperoxidase, proteinase 3, and the glomerular basement membrane are present in normal individuals. Kidney Int. 2010;78:590-7 pubmed publisher
    ..In this study, we determined whether natural autoantibodies against myeloperoxidase (MPO), proteinase 3 (PR3), and GBM were present in each of 10 healthy Chinese and Swedish individuals, ..
  15. Heilman K, Zilmer M, Zilmer K, Lintrop M, Kampus P, Kals J, et al. Arterial stiffness, carotid artery intima-media thickness and plasma myeloperoxidase level in children with type 1 diabetes. Diabetes Res Clin Pract. 2009;84:168-73 pubmed publisher
    ..functional-structural changes of the arteries along with a new biochemical marker of atherosclerosis, plasma myeloperoxidase level, in children with type 1 diabetes (T1DM). We studied 30 children with T1DM, aged 4.7-18...
  16. Reynolds W, Hiltunen M, Pirskanen M, Mannermaa A, Helisalmi S, Lehtovirta M, et al. MPO and APOEepsilon4 polymorphisms interact to increase risk for AD in Finnish males. Neurology. 2000;55:1284-90 pubmed
    b>Myeloperoxidase (MPO) is present in senile plaques and surrounding reactive microglia, but not in normal brain parenchyma. MPO in plaques is highest in APOE epsilon4 carriers, suggesting a functional interaction...
  17. Pakakasama S, Chen T, Frawley W, Muller C, Douglass E, Tomlinson G. Myeloperoxidase promotor polymorphism and risk of hepatoblastoma. Int J Cancer. 2003;106:205-7 pubmed
    b>Myeloperoxidase (MPO) is a major enzyme found in neutrophils. Oxidation by MPO produces free radicals that demonstrate genotoxic properties...
  18. Bewick M, Conlon M, Lafrenie R. Polymorphisms in manganese superoxide dismutase, myeloperoxidase and glutathione-S-transferase and survival after treatment for metastatic breast cancer. Breast Cancer Res Treat. 2008;111:93-101 pubmed
    ..005 and 0.006 for PFS and BCSS, respectively. These results suggest that SNPs in genes involved in drug metabolism may influence survival outcome for patients with MBC receiving HDC and ASCT. ..
  19. Baldus S, Heitzer T, Eiserich J, Lau D, Mollnau H, Ortak M, et al. Myeloperoxidase enhances nitric oxide catabolism during myocardial ischemia and reperfusion. Free Radic Biol Med. 2004;37:902-11 pubmed
    ..Whereas myeloperoxidase (MPO), a highly abundant, PMN-derived heme protein facilitates oxidative NO consumption and impairs vascular ..
  20. Crawford F, Freeman M, Schinka J, Morris M, Abdullah L, Richards D, et al. Association between Alzheimer's disease and a functional polymorphism in the Myeloperoxidase gene. Exp Neurol. 2001;167:456-9 pubmed
    A polymorphism in the Myeloperoxidase gene (MPO) has previously been demonstrated to be associated with gender-specific risk in an Alzheimer's Disease (AD) autopsy sample...
  21. Meisel P, Krause T, Cascorbi I, Schroeder W, Herrmann F, John U, et al. Gender and smoking-related risk reduction of periodontal disease with variant myeloperoxidase alleles. Genes Immun. 2002;3:102-6 pubmed
    b>Myeloperoxidase (MPO) is an oxidative enzyme expressed in polymorphonuclear leukocytes. It is involved in the defence against periodontal bacteria, and is also able to mediate inflammatory tissue destruction in periodontal disease...
  22. Pecoits Filho R, Stenvinkel P, Marchlewska A, Heimburger O, Barany P, Hoff C, et al. A functional variant of the myeloperoxidase gene is associated with cardiovascular disease in end-stage renal disease patients. Kidney Int Suppl. 2003;:S172-6 pubmed
    ..b>Myeloperoxidase (MPO) is an abundant enzyme involved in the production of free radicals...
  23. Eiserich J, Baldus S, Brennan M, Ma W, Zhang C, Tousson A, et al. Myeloperoxidase, a leukocyte-derived vascular NO oxidase. Science. 2002;296:2391-4 pubmed
    b>Myeloperoxidase (MPO) is an abundant mammalian phagocyte hemoprotein thought to primarily mediate host defense reactions...
  24. Zienolddiny S, Campa D, Lind H, Ryberg D, Skaug V, Stangeland L, et al. A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers. Carcinogenesis. 2008;29:1164-9 pubmed publisher
    ..However, only four of the previously reported associations with polymorphisms in the GSTP1 (Ala14Val), SOD2 (Val16Ala), EPHX1 (His139Arg) genes and the NAT1 fast acetylator phenotype remained significantly associated with lung cancer. ..
  25. Rensen S, Slaats Y, Nijhuis J, Jans A, Bieghs V, Driessen A, et al. Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis. Am J Pathol. 2009;175:1473-82 pubmed publisher
    ..b>Myeloperoxidase (MPO) is an important neutrophil enzyme that can generate aggressive oxidants; therefore, we studied the ..
  26. Ahn J, Ambrosone C, Kanetsky P, Tian C, Lehman T, Kropp S, et al. Polymorphisms in genes related to oxidative stress (CAT, MnSOD, MPO, and eNOS) and acute toxicities from radiation therapy following lumpectomy for breast cancer. Clin Cancer Res. 2006;12:7063-70 pubmed
    ..via generation of massive oxidative stress, we hypothesized that catalase, manganese superoxide dismutase, myeloperoxidase (MPO), and endothelial nitric oxide synthase (eNOS) genotypes might result in greater risk of radiotoxicity...
  27. Klinchid J, Chewaskulyoung B, Saeteng S, Lertprasertsuke N, Kasinrerk W, Cressey R. Effect of combined genetic polymorphisms on lung cancer risk in northern Thai women. Cancer Genet Cytogenet. 2009;195:143-9 pubmed publisher
    ..Confirmation would require further investigations with larger sample sizes. ..
  28. Pignatelli P, Loffredo L, Martino F, Catasca E, Carnevale R, Zanoni C, et al. Myeloperoxidase overexpression in children with hypercholesterolemia. Atherosclerosis. 2009;205:239-43 pubmed publisher
    ..We performed a cross-sectional study comparing 8-hydroxy-2'deoxyguanosine, oxidized-LDL and myeloperoxidase plasma levels in 95 normocholesterolemic and 95 hypercholesterolemic children...
  29. Gilliland F, Harms H, Crowell R, Li Y, Willink R, Belinsky S. Glutathione S-transferase P1 and NADPH quinone oxidoreductase polymorphisms are associated with aberrant promoter methylation of P16(INK4a) and O(6)-methylguanine-DNA methyltransferase in sputum. Cancer Res. 2002;62:2248-52 pubmed
    ..functional polymorphic variants of the NADPH quinone oxidoreductase, glutathione S-transferases P1 and M1, myeloperoxidase, and XRCC1 genes are associated with p16 and/or MGMT promoter methylation in sputum from cancer-free subjects ..
  30. Miric D, Katanic R, Kisic B, Zoric L, Miric B, Mitic R, et al. Oxidative stress and myeloperoxidase activity during bacterial meningitis: effects of febrile episodes and the BBB permeability. Clin Biochem. 2010;43:246-52 pubmed publisher
    To investigate participation of extracellular myeloperoxidase (MPO) in oxidative stress during different courses of the bacterial meningitis (BM).
  31. Chu H, Wang M, Wang M, Gu D, Wu D, Zhang Z, et al. The MPO -463G>A polymorphism and cancer risk: a meta-analysis based on 43 case-control studies. Mutagenesis. 2010;25:389-95 pubmed publisher
    b>Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species and plays an important role in the aetiology of cancer...
  32. Chooklin S, Pereyaslov A, Bihalskyy I. Pathogenic role of myeloperoxidase in acute pancreatitis. Hepatobiliary Pancreat Dis Int. 2009;8:627-31 pubmed
    b>Myeloperoxidase (MPO) has been implicated in promoting tissue damage in various inflammatory diseases. However, MPO blood levels in relation to the severity of acute pancreatitis (AP) and its time-course have not been studied...
  33. Banerjee S, Stampler J, Furtmüller P, Obinger C. Conformational and thermal stability of mature dimeric human myeloperoxidase and a recombinant monomeric form from CHO cells. Biochim Biophys Acta. 2011;1814:375-87 pubmed publisher
    b>Myeloperoxidase (MPO) is a lysosomal heme enzyme present in the azurophilic granules of human neutrophils and monocytes. It is a critical element of the human innate immune system by exerting antimicrobial effects...
  34. Carpena X, Vidossich P, Schroettner K, Calisto B, Banerjee S, Stampler J, et al. Essential role of proximal histidine-asparagine interaction in mammalian peroxidases. J Biol Chem. 2009;284:25929-37 pubmed publisher
    ..The crystal structure of a mixture of glycoforms of myeloperoxidase (MPO) purified from granules of human leukocytes prompted us to revise the orientation of this asparagine and ..
  35. He C, Tamimi R, Hankinson S, Hunter D, Han J. A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk. Breast Cancer Res Treat. 2009;113:585-94 pubmed publisher
    Oxidative stress may be involved in breast carcinogenesis. Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species (ROS)...
  36. Metzler K, Fuchs T, Nauseef W, Reumaux D, Roesler J, Schulze I, et al. Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity. Blood. 2011;117:953-9 pubmed publisher
    The granule enzyme myeloperoxidase (MPO) plays an important role in neutrophil antimicrobial responses. However, the severity of immunodeficiency in patients carrying mutations in MPO is variable...
  37. Rees M, Whitelock J, Malle E, Chuang C, Iozzo R, Nilasaroya A, et al. Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan. Matrix Biol. 2010;29:63-73 pubmed publisher
    The potent oxidants hypochlorous acid (HOCl) and hypobromous acid (HOBr) are produced extracellularly by myeloperoxidase, following release of this enzyme from activated leukocytes...
  38. Reynolds W, Patel K, Pianko S, Blatt L, Nicholas J, McHutchison J. A genotypic association implicates myeloperoxidase in the progression of hepatic fibrosis in chronic hepatitis C virus infection. Genes Immun. 2002;3:345-9 pubmed
    ..cells heavily represented in the inflammatory cell response, contain the oxidant generating enzyme myeloperoxidase (MPO)...
  39. Kettle A, Anderson R, Hampton M, Winterbourn C. Reactions of superoxide with myeloperoxidase. Biochemistry. 2007;46:4888-97 pubmed
    When neutrophils ingest bacteria, they discharge superoxide and myeloperoxidase into phagosomes. Both are essential for killing of the phagocytosed micro-organisms...
  40. Olson S, Carlson M, Ostrer H, Harlap S, Stone A, Winters M, et al. Genetic variants in SOD2, MPO, and NQO1, and risk of ovarian cancer. Gynecol Oncol. 2004;93:615-20 pubmed
    ..Since the genes superoxide dismutase (SOD2), myeloperoxidase (MPO), and NAD(P)H:quinone oxidoreductase 1 (NQO1) are involved in inflammation and oxidative stress, we ..
  41. Zappia M, Manna I, Serra P, Cittadella R, Andreoli V, La Russa A, et al. Increased risk for Alzheimer disease with the interaction of MPO and A2M polymorphisms. Arch Neurol. 2004;61:341-4 pubmed
    The genes encoding myeloperoxidase (MPO) and alpha(2)-macroglobulin (A2M) are involved in molecular pathways leading to beta-amyloid deposition...
  42. Lu W, Xing D, Qi J, Tan W, Miao X, Lin D. Genetic polymorphism in myeloperoxidase but not GSTM1 is associated with risk of lung squamous cell carcinoma in a Chinese population. Int J Cancer. 2002;102:275-9 pubmed
    b>Myeloperoxidase (MPO), an enzyme derived from neutrophils, metabolically activates a wide range of carcinogens, whereas glutathione S-transferase M1 (GSTM1) detoxifies various electrophilic metabolites...
  43. El Kebir D, Jozsef L, Pan W, Filep J. Myeloperoxidase delays neutrophil apoptosis through CD11b/CD18 integrins and prolongs inflammation. Circ Res. 2008;103:352-9 pubmed publisher
    ..b>Myeloperoxidase (MPO), a heme protein abundantly expressed in neutrophils, is generally associated with killing of bacteria ..
  44. Dally H, Gassner K, Jäger B, Schmezer P, Spiegelhalder B, Edler L, et al. Myeloperoxidase (MPO) genotype and lung cancer histologic types: the MPO -463 A allele is associated with reduced risk for small cell lung cancer in smokers. Int J Cancer. 2002;102:530-5 pubmed
    ..We confirm that the MPO -463 A variant affords a protective effect against lung cancer risk in smokers, which was strongest for SCLC patients. ..
  45. Hung R, Boffetta P, Brennan P, Malaveille C, Gelatti U, Placidi D, et al. Genetic polymorphisms of MPO, COMT, MnSOD, NQO1, interactions with environmental exposures and bladder cancer risk. Carcinogenesis. 2004;25:973-8 pubmed
    ..Several enzymes, which play key roles in oxidative stress are polymorphic in humans. Myeloperoxidase (MPO) produces a strong oxidant for microbicidal activity, and activates carcinogens in tobacco smoke...
  46. Feyler A, Voho A, Bouchardy C, Kuokkanen K, Dayer P, Hirvonen A, et al. Point: myeloperoxidase -463G --> a polymorphism and lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2002;11:1550-4 pubmed
    b>Myeloperoxidase (MPO) is released from neutrophils in lung tissue in response to exposure to various pulmonary insults, including tobacco smoking...
  47. Brockstedt U, Krajinovic M, Richer C, Mathonnet G, Sinnett D, Pfau W, et al. Analyses of bulky DNA adduct levels in human breast tissue and genetic polymorphisms of cytochromes P450 (CYPs), myeloperoxidase (MPO), quinone oxidoreductase (NQO1), and glutathione S-transferases (GSTs). Mutat Res. 2002;516:41-7 pubmed
    ..When the MPO and GSTP1 were examined together, individuals with these combined variant genotypes had significantly higher adduct levels than all other genotype combinations (P=0.003). ..
  48. Chan E, Lam S, Fu K, Kwong Y. Polymorphisms of the GSTM1, GSTP1, MPO, XRCC1, and NQO1 genes in Chinese patients with non-small cell lung cancers: relationship with aberrant promoter methylation of the CDKN2A and RARB genes. Cancer Genet Cytogenet. 2005;162:10-20 pubmed
    ..at polymorphic sites of the glutathione S-transferase (GST) M1 (null/wildtype) and P1 (nucleotide 2627 A/G), myeloperoxidase (MPO) (nucleotide -463 G/A), X-ray repair cross-complementing group 1 (XRCC1) (nucleotides 26304 C/T; 28152 G/..
  49. Furtmüller P, Arnhold J, Jantschko W, Pichler H, Obinger C. Redox properties of the couples compound I/compound II and compound II/native enzyme of human myeloperoxidase. Biochem Biophys Res Commun. 2003;301:551-7 pubmed
    b>Myeloperoxidase (MPO) is an important component of the neutrophil's antimicrobial armory and has been implicated in promoting tissue damage in numerous inflammatory diseases...
  50. Van Schooten F, Boots A, Knaapen A, Godschalk R, Maas L, Borm P, et al. Myeloperoxidase (MPO) -463G->A reduces MPO activity and DNA adduct levels in bronchoalveolar lavages of smokers. Cancer Epidemiol Biomarkers Prev. 2004;13:828-33 pubmed
    The myeloperoxidase (MPO) -463G-->A genetic polymorphism is associated with a reduced risk for lung cancer, but the underlying mechanism is not yet elucidated...
  51. Schabath M, Spitz M, Delclos G, Gunn G, Whitehead L, Wu X. Association between asbestos exposure, cigarette smoking, myeloperoxidase (MPO) genotypes, and lung cancer risk. Am J Ind Med. 2002;42:29-37 pubmed
    ..in tobacco-associated carcinogenesis, genetic factors such as the polymorphic metabolic/oxidative enzyme myeloperoxidase (MPO) could modulate individual susceptibility to asbestos-associated carcinogenesis...
  52. Harms C, Salama S, Sierra Torres C, Cajas Salazar N, Au W. Polymorphisms in DNA repair genes, chromosome aberrations, and lung cancer. Environ Mol Mutagen. 2004;44:74-82 pubmed
    ..The observation that patients had significantly increased CA frequencies compared with controls, irrespective of genotype, suggests that patients have additional factors that contribute to the development of lung cancer. ..
  53. Misra R, Tangrea J, Virtamo J, Ratnasinghe D, Andersen M, Barrett M, et al. Variation in the promoter region of the myeloperoxidase gene is not directly related to lung cancer risk among male smokers in Finland. Cancer Lett. 2001;164:161-7 pubmed
    In order to examine whether a polymorphism in the promoter region of the myeloperoxidase (MPO) gene is associated with lung cancer among male smokers, we conducted a case-control study nested within a Finnish clinical trial cohort...
  54. Yoon K, Kim J, Gil H, Hwang H, Hwangbo B, Lee J. CYP1B1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women. Lung Cancer. 2008;60:40-6 pubmed
  55. Kumar A, Piedrafita F, Reynolds W. Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the -463GA promoter polymorphism. J Biol Chem. 2004;279:8300-15 pubmed
    A functional myeloperoxidase (MPO) promoter polymorphism, -463GA, has been associated with incidence or severity of inflammatory diseases, including atherosclerosis and Alzheimer's disease, and some cancers...
  56. Ahn J, Gammon M, Santella R, Gaudet M, Britton J, Teitelbaum S, et al. Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer risk. Cancer Res. 2004;64:7634-9 pubmed
    b>Myeloperoxidase (MPO), an antimicrobial enzyme in the breast, generates reactive oxygen species (ROS) endogenously...
  57. Ambrosone C, Ahn J, Singh K, Rezaishiraz H, Furberg H, Sweeney C, et al. Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer. Cancer Res. 2005;65:1105-11 pubmed
    ..dismutase catalyzes conversion of superoxide radicals to H(2)O(2), with catalase neutralizing H(2)O(2) and myeloperoxidase converting H(2)O(2) to highly reactive hypochlorous acid, we hypothesized that gene variants could impact the ..
  58. Pabalan N, Jarjanazi H, Sung L, Li H, Ozcelik H. Menopausal status modifies breast cancer risk associated with the myeloperoxidase (MPO) G463A polymorphism in Caucasian women: a meta-analysis. PLoS ONE. 2012;7:e32389 pubmed publisher
    ..cancer susceptibility may be modulated partly through polymorphisms in oxidative enzymes, one of which is myeloperoxidase (MPO)...
  59. Arslan S, Pinarbasi H, Silig Y. Myeloperoxidase G-463A polymorphism and risk of lung and prostate cancer in a Turkish population. Mol Med Rep. 2011;4:87-92 pubmed publisher
    b>Myeloperoxidase (MPO) is a phase I enzyme that can bioactivate many specific procarcinogens, including polycyclic aromatic hydrocarbons and aromatic amines...
  60. Lu W, Qi J, Xing D, Tan W, Miao X, Su W, et al. [Lung cancer risk associated with genetic polymorphism in myeloperoxidase (-463 G/A) in a Chinese population]. Zhonghua Zhong Liu Za Zhi. 2002;24:250-3 pubmed
    ..between susceptibility to lung cancer among Chinese and genetic polymorphism at nucleotide -463 (G/A) in myeloperoxidase (MPO), an enzyme found in lysosomes of phagocytes and involved in the formation of hydroxyl radicals and ..
  61. Arnhold J, Flemmig J. Human myeloperoxidase in innate and acquired immunity. Arch Biochem Biophys. 2010;500:92-106 pubmed publisher
    ..One of the key components of PMNs is the heme-containing enzyme myeloperoxidase (MPO) that is stored in large amount in azurophilic granules of resting cells...
  62. Larsen J, Colosimo M, Yang I, Bowman R, Zimmerman P, Fong K. CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung. Carcinogenesis. 2006;27:525-32 pubmed
    ..Candidates include genetic variants of glutathione S-transferases (GSTM1, GSTT1 and GSTP1) and myeloperoxidase (MPO)...
  63. Baldus S, Rudolph V, Roiss M, Ito W, Rudolph T, Eiserich J, et al. Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase. Circulation. 2006;113:1871-8 pubmed
    Neutrophils and monocytes are centrally linked to vascular inflammatory disease, and leukocyte-derived myeloperoxidase (MPO) has emerged as an important mechanistic participant in impaired vasomotor function...
  64. Chevrier I, Stucker I, Houllier A, Cénée S, Beaune P, Laurent Puig P, et al. Myeloperoxidase: new polymorphisms and relation with lung cancer risk. Pharmacogenetics. 2003;13:729-39 pubmed
    b>Myeloperoxidase (MPO) is an haemoprotein that metabolizes tobacco smoke procarcinogens such as benzo(a)pyrene and aromatic amines into highly reactive intermediates...
  65. Li Y, Ambrosone C, McCullough M, Ahn J, Stevens V, Thun M, et al. Oxidative stress-related genotypes, fruit and vegetable consumption and breast cancer risk. Carcinogenesis. 2009;30:777-84 pubmed publisher
    ..Genetic variations in catalase (CAT) (C-262T), myeloperoxidase (MPO) (G-463A), endothelial nitric oxide synthase (NOS3) (G894T) and heme oxygenase-1 (HO-1) [(GT)(n) ..
  66. Schabath M, Spitz M, Hong W, Delclos G, Reynolds W, Gunn G, et al. A myeloperoxidase polymorphism associated with reduced risk of lung cancer. Lung Cancer. 2002;37:35-40 pubmed
    b>Myeloperoxidase (MPO) is a metabolic/oxidative enzyme found in neutrophils and monocytes that contributes to pulmonary carcinogenesis through activation of specific procarcinogens including benzo[a]pyrene intermediates, 4-aminobiphenyl ..
  67. Xu L, Liu G, Miller D, Zhou W, Lynch T, Wain J, et al. Counterpoint: the myeloperoxidase -463G-->a polymorphism does not decrease lung cancer susceptibility in Caucasians. Cancer Epidemiol Biomarkers Prev. 2002;11:1555-9 pubmed
    The myeloperoxidase (MPO) G-to-A substitution polymorphism in the promoter region of the MPO gene has been associated with a 40-70% reduction in lung cancer risk in several studies, although a recent nested case-control study disputes ..
  68. Ambrosone C, Barlow W, Reynolds W, Livingston R, Yeh I, Choi J, et al. Myeloperoxidase genotypes and enhanced efficacy of chemotherapy for early-stage breast cancer in SWOG-8897. J Clin Oncol. 2009;27:4973-9 pubmed publisher
    b>Myeloperoxidase (MPO) generates reactive oxygen species and also activates xenobiotics...
  69. Yang J, Ambrosone C, Hong C, Ahn J, Rodriguez C, Thun M, et al. Relationships between polymorphisms in NOS3 and MPO genes, cigarette smoking and risk of post-menopausal breast cancer. Carcinogenesis. 2007;28:1247-53 pubmed
    NOS3 and MPO genes encode endothelial nitric oxide synthase and myeloperoxidase (MPO), respectively, which generate nitric oxide and reactive oxygen species...
  70. Asselbergs F, Reynolds W, Cohen Tervaert J, Jessurun G, Tio R. Myeloperoxidase polymorphism related to cardiovascular events in coronary artery disease. Am J Med. 2004;116:429-30 pubmed
  71. Lin S, Chou Y, Wu M, Wu C, Lin W, Yu C, et al. Genetic variants of myeloperoxidase and catechol-O-methyltransferase and breast cancer risk. Eur J Cancer Prev. 2005;14:257-61 pubmed
    This nested case-control study evaluated the role of polymorphisms in the myeloperoxidase (MPO) and catechol-O-methyltransferase (COMT) genes that modulate oxidative stress in breast cancer risk in a Chinese population...
  72. Maki R, Tyurin V, Lyon R, Hamilton R, DeKosky S, Kagan V, et al. Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer disease. J Biol Chem. 2009;284:3158-69 pubmed publisher
    b>Myeloperoxidase (MPO) is expressed in Alzheimer disease (AD) but not normal aged brain. A functional -463G/A MPO promoter polymorphism has been associated with AD risk through as yet unidentified mechanisms...
  73. Timofeeva M, Kropp S, Sauter W, Beckmann L, Rosenberger A, Illig T, et al. Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer. Int J Cancer. 2010;127:1547-61 pubmed publisher
    ..To confirm these observations and to eliminate possible bias in our analyses, larger studies are warranted. ..
  74. Kantarci O, Lesnick T, Yang P, Meyer R, Hebrink D, McMurray C, et al. Myeloperoxidase -463 (G-->A) polymorphism associated with lower risk of lung cancer. Mayo Clin Proc. 2002;77:17-22 pubmed
    To study the association of the myeloperoxidase (MPO) -463 (G-->A) polymorphism with lung cancer risk...
  75. Hua F, Wang J, GU J, Li S, Liu H, Zhou Q. [A meta analysis on the relationship between myeloperoxidase G-463A genetic polymorphisms and lung cancer susceptibility]. Zhongguo Fei Ai Za Zhi. 2010;13:122-7 pubmed publisher
    The relationship between myeloperoxidase G-463A genetic polymorphisms and lung cancer susceptibility has been studied extensively. However, the outcomes are not consistent...
  76. Wu X, Zhou Y, Ren S, Hao Q. [Gene polymorphism of myeloperoxidase and genetic susceptibility to lung cancer]. Ai Zheng. 2003;22:912-5 pubmed
    A-463 bp G/A polymorphism is located in the promoter region of myeloperoxidase (MPO) gene was found to be associated with lung cancer susceptibility; however, this association in Chinese population remained unclear...