myeloperoxidase

Summary

Gene Symbol: myeloperoxidase
Description: myeloperoxidase
Species: human

Top Publications

  1. ncbi [Disturbed neutrophil activation in pneumonia during medicinal immunosuppression]
    J Braun
    Medizinische Klinik II,
    Pneumologie 51:1037-42. 1997
  2. ncbi Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic antibodies
    R Kettritz
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    J Am Soc Nephrol 12:37-46. 2001
  3. ncbi Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritis
    Hermann Josef Grone
    Department of Cellular and Molecular Pathology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Lab Invest 82:5-14. 2002
  4. ncbi Myeloperoxidase G-463A polymorphism and Alzheimer's disease in the ApoEurope study
    Brigitte Leininger-Muller
    INSERM Unite 525, Centre de Médecine Préventive and Faculté de Pharmacie, Nancy, France
    Neurosci Lett 349:95-8. 2003
  5. ncbi The effects of high-intensity exercise on skeletal muscle neutrophil myeloperoxidase in untrained and trained rats
    Vladimir I Morozov
    Department of Biochemistry, Research Institute of Physical Culture, Dynamo Ave 2, St Petersburg 197110, Russia
    Eur J Appl Physiol 97:716-22. 2006
  6. doi The MPO -463G>A polymorphism and cancer risk: a meta-analysis based on 43 case-control studies
    Haiyan Chu
    Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
    Mutagenesis 25:389-95. 2010
  7. pmc Elevated plasma free fatty acids increase cardiovascular risk by inducing plasma biomarkers of endothelial activation, myeloperoxidase and PAI-1 in healthy subjects
    Manoj Mathew
    Diabetes Division, Department of Medicine, The University of Texas Health Science Center at San Antonio, Texas 78229, USA
    Cardiovasc Diabetol 9:9. 2010
  8. ncbi Oxidative stress and myeloperoxidase activity during bacterial meningitis: effects of febrile episodes and the BBB permeability
    Dijana Miric
    Institute of Biochemistry, Medical Faculty Pristina Kosovska Mirtovica, Anri Dinana bb, 38220, Kosovska Mitrovica, Serbia
    Clin Biochem 43:246-52. 2010
  9. ncbi Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway
    Halla Skuladottir
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark
    Lung Cancer 48:187-99. 2005
  10. ncbi Myeloperoxidase inactivates TIMP-1 by oxidizing its N-terminal cysteine residue: an oxidative mechanism for regulating proteolysis during inflammation
    Yi Wang
    Department of Medicine, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington 98195, USA
    J Biol Chem 282:31826-34. 2007

Detail Information

Publications233 found, 100 shown here

  1. ncbi [Disturbed neutrophil activation in pneumonia during medicinal immunosuppression]
    J Braun
    Medizinische Klinik II,
    Pneumologie 51:1037-42. 1997
    ..In addition to the cell differential the BALF concentrations of the neutrophil degranulation products myeloperoxidase (MPO) and lactoferrin were determined using immunoluminometric assays...
  2. ncbi Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic antibodies
    R Kettritz
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    J Am Soc Nephrol 12:37-46. 2001
    ..TNF-alpha-primed neutrophils were stimulated with monoclonal antibodies (MAb) to human myeloperoxidase (MPO) and proteinase 3 (PR3), and with preparations of human ANCA (three patients with PR3-ANCA and two ..
  3. ncbi Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritis
    Hermann Josef Grone
    Department of Cellular and Molecular Pathology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Lab Invest 82:5-14. 2002
    ..the nature of the in vivo oxidants has not been clearly identified, increasing evidence suggested the myeloperoxidase (MPO)-H(2)O(2)-halide system to be responsible for the damage observed in leukocyte-dependent ..
  4. ncbi Myeloperoxidase G-463A polymorphism and Alzheimer's disease in the ApoEurope study
    Brigitte Leininger-Muller
    INSERM Unite 525, Centre de Médecine Préventive and Faculté de Pharmacie, Nancy, France
    Neurosci Lett 349:95-8. 2003
    ..A polymorphism in the myeloperoxidase gene (MPO) has previously been associated with AD susceptibility...
  5. ncbi The effects of high-intensity exercise on skeletal muscle neutrophil myeloperoxidase in untrained and trained rats
    Vladimir I Morozov
    Department of Biochemistry, Research Institute of Physical Culture, Dynamo Ave 2, St Petersburg 197110, Russia
    Eur J Appl Physiol 97:716-22. 2006
    ..Neutrophil enzyme myeloperoxidase (MPO) was determined as a measure of neutrophil migration into muscles and blood neutrophil degranulation...
  6. doi The MPO -463G>A polymorphism and cancer risk: a meta-analysis based on 43 case-control studies
    Haiyan Chu
    Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
    Mutagenesis 25:389-95. 2010
    b>Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species and plays an important role in the aetiology of cancer...
  7. pmc Elevated plasma free fatty acids increase cardiovascular risk by inducing plasma biomarkers of endothelial activation, myeloperoxidase and PAI-1 in healthy subjects
    Manoj Mathew
    Diabetes Division, Department of Medicine, The University of Texas Health Science Center at San Antonio, Texas 78229, USA
    Cardiovasc Diabetol 9:9. 2010
    ..We examined the contribution of FFA to these abnormalities following a 48-hour physiological increase in plasma FFA to levels of obesity and diabetes in a group of healthy subjects...
  8. ncbi Oxidative stress and myeloperoxidase activity during bacterial meningitis: effects of febrile episodes and the BBB permeability
    Dijana Miric
    Institute of Biochemistry, Medical Faculty Pristina Kosovska Mirtovica, Anri Dinana bb, 38220, Kosovska Mitrovica, Serbia
    Clin Biochem 43:246-52. 2010
    To investigate participation of extracellular myeloperoxidase (MPO) in oxidative stress during different courses of the bacterial meningitis (BM).
  9. ncbi Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway
    Halla Skuladottir
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark
    Lung Cancer 48:187-99. 2005
    ..The effect modification was generally strongest at lower levels of smoking...
  10. ncbi Myeloperoxidase inactivates TIMP-1 by oxidizing its N-terminal cysteine residue: an oxidative mechanism for regulating proteolysis during inflammation
    Yi Wang
    Department of Medicine, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington 98195, USA
    J Biol Chem 282:31826-34. 2007
    ..the interaction of TIMPs with MMPs might involve hypochlorous acid (HOCl), a potent oxidant produced by the myeloperoxidase (MPO) system of phagocytes...
  11. doi A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers
    Shanbeh Zienolddiny
    Section of Toxicology, Department of Biological and Chemical Work Environment, National Institute of Occupational Health N 0033, Oslo, Norway
    Carcinogenesis 29:1164-9. 2008
    ..However, only four of the previously reported associations with polymorphisms in the GSTP1 (Ala14Val), SOD2 (Val16Ala), EPHX1 (His139Arg) genes and the NAT1 fast acetylator phenotype remained significantly associated with lung cancer...
  12. pmc Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis
    Sander S Rensen
    Department of Surgery, Maastricht University Medical Centre, PO Box 616, Maastricht 6200 MD, The Netherlands
    Am J Pathol 175:1473-82. 2009
    ..b>Myeloperoxidase (MPO) is an important neutrophil enzyme that can generate aggressive oxidants; therefore, we studied the ..
  13. ncbi A myeloperoxidase polymorphism associated with reduced risk of lung cancer
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Box 189, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Lung Cancer 37:35-40. 2002
    b>Myeloperoxidase (MPO) is a metabolic/oxidative enzyme found in neutrophils and monocytes that contributes to pulmonary carcinogenesis through activation of specific procarcinogens including benzo[a]pyrene intermediates, 4-aminobiphenyl ..
  14. ncbi Myeloperoxidase mediates cell adhesion via the alpha M beta 2 integrin (Mac-1, CD11b/CD18)
    M W Johansson
    Department of Physiological Botany, University of Uppsala, Villavagen 6, Sweden
    J Cell Sci 110:1133-9. 1997
    b>Myeloperoxidase is a leukocyte component able to generate potent microbicidal substances. A homologous invertebrate blood cell protein, peroxinectin, is not only a peroxidase but also a cell adhesion ligand...
  15. pmc A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk
    Chunyan He
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Breast Cancer Res Treat 113:585-94. 2009
    Oxidative stress may be involved in breast carcinogenesis. Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species (ROS)...
  16. ncbi Genetic variants of myeloperoxidase and catechol-O-methyltransferase and breast cancer risk
    S C Lin
    School of Public Health, National Defense Medical Center, No 161, Section 6 Min Chuan East Road, Taipei 114, Taiwan, Republic of China
    Eur J Cancer Prev 14:257-61. 2005
    This nested case-control study evaluated the role of polymorphisms in the myeloperoxidase (MPO) and catechol-O-methyltransferase (COMT) genes that modulate oxidative stress in breast cancer risk in a Chinese population...
  17. ncbi Pathogenic role of myeloperoxidase in acute pancreatitis
    Serge Chooklin
    Department of Surgery, Medical University, Lviv, Ukraine
    Hepatobiliary Pancreat Dis Int 8:627-31. 2009
    b>Myeloperoxidase (MPO) has been implicated in promoting tissue damage in various inflammatory diseases. However, MPO blood levels in relation to the severity of acute pancreatitis (AP) and its time-course have not been studied...
  18. ncbi Variation in the promoter region of the myeloperoxidase gene is not directly related to lung cancer risk among male smokers in Finland
    R R Misra
    Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, 6006 Executive Boulevard, Suite 321, Bethesda, MD 20892 7058, USA
    Cancer Lett 164:161-7. 2001
    In order to examine whether a polymorphism in the promoter region of the myeloperoxidase (MPO) gene is associated with lung cancer among male smokers, we conducted a case-control study nested within a Finnish clinical trial cohort...
  19. pmc Myeloperoxidase genotypes and enhanced efficacy of chemotherapy for early-stage breast cancer in SWOG-8897
    Christine B Ambrosone
    Roswell Park Cancer Institute, Department of Cancer Prevention and Control, Buffalo, NY 14263, USA
    J Clin Oncol 27:4973-9. 2009
    b>Myeloperoxidase (MPO) generates reactive oxygen species and also activates xenobiotics...
  20. doi Oxidative stress-related genotypes, fruit and vegetable consumption and breast cancer risk
    Yulin Li
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Carcinogenesis 30:777-84. 2009
    ..Genetic variations in catalase (CAT) (C-262T), myeloperoxidase (MPO) (G-463A), endothelial nitric oxide synthase (NOS3) (G894T) and heme oxygenase-1 (HO-1) [(GT)(n) ..
  21. ncbi Point: myeloperoxidase -463G --> a polymorphism and lung cancer risk
    Anne Feyler
    Unit of Cancer Epidemiology INSERM U521, Gustave Roussy Institute, 94805 Villejuif, France
    Cancer Epidemiol Biomarkers Prev 11:1550-4. 2002
    b>Myeloperoxidase (MPO) is released from neutrophils in lung tissue in response to exposure to various pulmonary insults, including tobacco smoking...
  22. ncbi CYP1B1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women
    Kyong Ah Yoon
    Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, South Korea
    Lung Cancer 60:40-6. 2008
    ....
  23. ncbi Polymorphisms in DNA repair genes, chromosome aberrations, and lung cancer
    Carsten Harms
    Center of Environmental Research and Technology, Laboratory of Bioanalytic, UFT, University of Bremen, Bremen, Germany
    Environ Mol Mutagen 44:74-82. 2004
    ..The observation that patients had significantly increased CA frequencies compared with controls, irrespective of genotype, suggests that patients have additional factors that contribute to the development of lung cancer...
  24. ncbi Myeloperoxidase -463 (G-->A) polymorphism associated with lower risk of lung cancer
    Orhun H Kantarci
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 77:17-22. 2002
    To study the association of the myeloperoxidase (MPO) -463 (G-->A) polymorphism with lung cancer risk.
  25. doi Myeloperoxidase G-463A polymorphism and risk of lung and prostate cancer in a Turkish population
    Serdal Arslan
    Department of Molecular Biology and Genetics, Faculty of Science, Cumhuriyet University, 58140 Sivas, Turkey
    Mol Med Rep 4:87-92. 2011
    b>Myeloperoxidase (MPO) is a phase I enzyme that can bioactivate many specific procarcinogens, including polycyclic aromatic hydrocarbons and aromatic amines...
  26. ncbi Myeloperoxidase -463G>A polymorphism and risk of primary lung cancer in a Korean population
    Jae Hyung Park
    Department of Internal Medicine, Kyungpook National University Hospital, Samduk 2Ga 50, Daegu 700 412, South Korea
    Cancer Detect Prev 30:257-61. 2006
    b>Myeloperoxidase (MPO) contributes to pulmonary carcinogenesis through activation of a wide range of tobacco smoke procarcinogens, including benzo[a]pyrene and aromatic amines...
  27. ncbi Increased myeloperoxidase and lipid peroxide-modified protein in gynecological malignancies
    M Song
    Department of Gynecology and Obstetrics, Emory University, School of Medicine, Atlanta, GA 30322, USA
    Antioxid Redox Signal 3:1139-46. 2001
    ..In this study, we measured the levels of myeloperoxidase (MPO), an enzyme associated with oxidation and autoantibodies to lipid peroxide-modified protein (LOOH-RSA), ..
  28. doi [A meta analysis on the relationship between myeloperoxidase G-463A genetic polymorphisms and lung cancer susceptibility]
    Feng Hua
    Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenviroment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China
    Zhongguo Fei Ai Za Zhi 13:122-7. 2010
    The relationship between myeloperoxidase G-463A genetic polymorphisms and lung cancer susceptibility has been studied extensively. However, the outcomes are not consistent...
  29. doi Functional polymorphism of the myeloperoxidase gene in hypertensive nephrosclerosis dialysis patients
    Kent Doi
    Department of Nephrology and Endocrinology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Hypertens Res 30:1193-8. 2007
    b>Myeloperoxidase (MPO) may play an important role not only in host defense reactions but also in local inflammations, especially in atherosclerotic diseases such as hypertensive nephrosclerosis (HN)...
  30. ncbi Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte colony-stimulating factor
    K Morishita
    Institute of Medical Science, University of Tokyo, Japan
    J Biol Chem 262:15208-13. 1987
    By using the full-length cDNA as a probe, the chromosomal gene for human myeloperoxidase was isolated from a human gene library...
  31. ncbi Myeloperoxidase and paraoxonase-1 in type 2 diabetic patients
    F R Jornayvaz
    Service of Endocrinology, Diabetes and Nutrition, Department of Internal Medicine, Faculty of Medicine, Geneva University, Geneva, Switzerland
    Nutr Metab Cardiovasc Dis 19:613-9. 2009
    Reduced high density lipoproteins (HDL) and increased oxidative stress are features of type 2 diabetes. Myeloperoxidase is an oxidative enzyme partly associated with HDL and causing HDL dysfunction...
  32. doi Enzyme levels and G-463A polymorphism of myeloperoxidase in chronic lymphocytic leukemia and multiple myeloma
    Eyup Ilker Saygili
    Vocational School of Higher Education for Health Services, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey
    Leuk Lymphoma 50:2030-7. 2009
    The aim of this study was to investigate how myeloperoxidase (MPO) G-463A gene polymorphism and enzyme levels varied among patients with chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) and to find the relationship between ..
  33. ncbi Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer risk
    Jiyoung Ahn
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Cancer Res 64:7634-9. 2004
    b>Myeloperoxidase (MPO), an antimicrobial enzyme in the breast, generates reactive oxygen species (ROS) endogenously...
  34. ncbi Relationships between polymorphisms in NOS3 and MPO genes, cigarette smoking and risk of post-menopausal breast cancer
    Jun Yang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 28:1247-53. 2007
    NOS3 and MPO genes encode endothelial nitric oxide synthase and myeloperoxidase (MPO), respectively, which generate nitric oxide and reactive oxygen species...
  35. doi Elevated levels of myeloperoxidase, white blood cell count and 3-chlorotyrosine in Taiwanese patients with acute myocardial infarction
    Mei Ling Cheng
    Graduate Institute of Medical Biotechnology and Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    Clin Biochem 41:554-60. 2008
    ..risk factor for acute myocardial infarction (AMI), is associated with leukocytic activation, secretion of myeloperoxidase (MPO) and generation of the oxidative damage marker, 3-chlorotyrosine (3-Cl-Tyr)...
  36. ncbi Myeloperoxidase-dependent caspase-3 activation and apoptosis in HL-60 cells: protection by the antioxidants ascorbate and (dihydro)lipoic acid
    Melinda C Myzak
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 6512, USA
    Redox Rep 7:47-53. 2002
    The heme enzyme myeloperoxidase (MPO) has recently been implicated in hydrogen peroxide H(2)O(2)-induced apoptosis of HL-60 human leukemia cells...
  37. ncbi X-ray crystal structure of canine myeloperoxidase at 3 A resolution
    J Zeng
    Department of Biochemistry and Molecular Biology, University of Miami Medical School, FL 33101
    J Mol Biol 226:185-207. 1992
    The three-dimensional structure of the enzyme myeloperoxidase has been determined by X-ray crystallography to 3 A resolution...
  38. ncbi Myeloperoxidase: new polymorphisms and relation with lung cancer risk
    Isabelle Chevrier
    UMRS INSERM 490, Molecular Toxicology, Faculté des Saints Pères, Paris, France
    Pharmacogenetics 13:729-39. 2003
    b>Myeloperoxidase (MPO) is an haemoprotein that metabolizes tobacco smoke procarcinogens such as benzo(a)pyrene and aromatic amines into highly reactive intermediates...
  39. ncbi Unique autolytic cleavage of human myeloperoxidase. Implications for the involvement of active site MET409
    K L Taylor
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 3050
    J Biol Chem 267:25282-8. 1992
    b>Myeloperoxidase (MPO) is a functionally important component of the normal human neutrophil host defense system...
  40. pmc Glycosylation pattern of mature dimeric leukocyte and recombinant monomeric myeloperoxidase: glycosylation is required for optimal enzymatic activity
    Pierre Van Antwerpen
    Laboratory of Pharmaceutical Chemistry and the Analytical Platform of Institute of Pharmacy, UniversitéLibre de Bruxelles, Brussels, Belgium
    J Biol Chem 285:16351-9. 2010
    The involvement of myeloperoxidase (MPO) in various inflammatory conditions has been the scope of many recent studies...
  41. ncbi Killing activity of neutrophils is mediated through activation of proteases by K+ flux
    Emer P Reeves
    Centre for Molecular Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
    Nature 416:291-7. 2002
    ..by subjecting them to high concentrations of highly toxic reactive oxygen species (ROS) and bringing about myeloperoxidase-catalysed halogenation...
  42. doi Arterial stiffness, carotid artery intima-media thickness and plasma myeloperoxidase level in children with type 1 diabetes
    Kaire Heilman
    Department of Paediatrics, University of Tartu, Tartu, Estonia
    Diabetes Res Clin Pract 84:168-73. 2009
    The present study investigated the functional-structural changes of the arteries along with a new biochemical marker of atherosclerosis, plasma myeloperoxidase level, in children with type 1 diabetes (T1DM).
  43. ncbi Human myeloperoxidase: structure of a cyanide complex and its interaction with bromide and thiocyanate substrates at 1.9 A resolution
    M Blair-Johnson
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Biochemistry 40:13990-7. 2001
    The 1.9 A X-ray crystal structure of human myeloperoxidase complexed with cyanide (R = 0.175, R(free) = 0...
  44. ncbi Myeloperoxidase genetic polymorphisms modulate human neutrophil enzyme activity: genetic determinants for atherosclerosis?
    Isabelle Chevrier
    Universite Paris Descartes, Faculte de Medecine, INSERM UMRS 490, 45 Rue des Saints Peres, 75270 Paris Cedex 06, France
    Atherosclerosis 188:150-4. 2006
    b>Myeloperoxidase (MPO), an abundant leukocyte hemoprotein has been linked to atherosclerosis and cardiovascular disease. We previously found new genetic polymorphisms in MPO gene...
  45. ncbi X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8 A resolution
    T J Fiedler
    Department of Biochemistry and Molecular Biology, University of Miami Medical School, Miami, Florida 33136, USA
    J Biol Chem 275:11964-71. 2000
    The x-ray crystal structure of human myeloperoxidase has been extended to 1.8 A resolution, using x-ray data recorded at -180 degrees C (r = 0.197, free r = 0.239)...
  46. ncbi Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis
    Pierre Nahon
    Service d Hepatologie, Hopital Jean Verdier, AP HP, Bondy, France
    Hepatology 50:1484-93. 2009
    ..formation in hepatocyte mitochondria and by reduced nicotinamide adenine dinucleotide phosphate oxidases and myeloperoxidase (MPO) in Kupffer cells and liver-infiltrating neutrophils...
  47. ncbi Myeloperoxidase enhances nitric oxide catabolism during myocardial ischemia and reperfusion
    Stephan Baldus
    Department of Cardiology, University Hospital Hamburg Eppendorf, 20246 Hamburg, Germany
    Free Radic Biol Med 37:902-11. 2004
    ..Whereas myeloperoxidase (MPO), a highly abundant, PMN-derived heme protein facilitates oxidative NO consumption and impairs vascular ..
  48. ncbi Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer
    Christine B Ambrosone
    Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Res 65:1105-11. 2005
    ..dismutase catalyzes conversion of superoxide radicals to H(2)O(2), with catalase neutralizing H(2)O(2) and myeloperoxidase converting H(2)O(2) to highly reactive hypochlorous acid, we hypothesized that gene variants could impact the ..
  49. ncbi Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the -463GA promoter polymorphism
    Alan P Kumar
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    J Biol Chem 279:8300-15. 2004
    A functional myeloperoxidase (MPO) promoter polymorphism, -463GA, has been associated with incidence or severity of inflammatory diseases, including atherosclerosis and Alzheimer's disease, and some cancers...
  50. ncbi A genotypic association implicates myeloperoxidase in the progression of hepatic fibrosis in chronic hepatitis C virus infection
    W F Reynolds
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Genes Immun 3:345-9. 2002
    ..cells heavily represented in the inflammatory cell response, contain the oxidant generating enzyme myeloperoxidase (MPO)...
  51. ncbi Counterpoint: the myeloperoxidase -463G-->a polymorphism does not decrease lung cancer susceptibility in Caucasians
    Li Lian Xu
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1555-9. 2002
    The myeloperoxidase (MPO) G-to-A substitution polymorphism in the promoter region of the MPO gene has been associated with a 40-70% reduction in lung cancer risk in several studies, although a recent nested case-control study disputes ..
  52. ncbi Association between asbestos exposure, cigarette smoking, myeloperoxidase (MPO) genotypes, and lung cancer risk
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Holcombe Blvd, Houston, Texas 77303, USA
    Am J Ind Med 42:29-37. 2002
    As observed in tobacco-associated carcinogenesis, genetic factors such as the polymorphic metabolic/oxidative enzyme myeloperoxidase (MPO) could modulate individual susceptibility to asbestos-associated carcinogenesis.
  53. ncbi Myeloperoxidase (MPO) genotype and lung cancer histologic types: the MPO -463 A allele is associated with reduced risk for small cell lung cancer in smokers
    Heike Dally
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 102:530-5. 2002
    ..We confirm that the MPO -463 A variant affords a protective effect against lung cancer risk in smokers, which was strongest for SCLC patients...
  54. ncbi Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes
    Stephan Baldus
    University of Hamburg, Department of Cardiology, Martinistrasse 52, 20246 Hamburg, Germany
    Circulation 108:1440-5. 2003
    ..b>Myeloperoxidase (MPO), a hemoprotein abundantly expressed by PMNs and secreted during activation, possesses potent ..
  55. ncbi Genetic variants in SOD2, MPO, and NQO1, and risk of ovarian cancer
    S H Olson
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Gynecol Oncol 93:615-20. 2004
    ..Since the genes superoxide dismutase (SOD2), myeloperoxidase (MPO), and NAD(P)H:quinone oxidoreductase 1 (NQO1) are involved in inflammation and oxidative stress, we ..
  56. ncbi Myeloperoxidase (MPO) -463G->A reduces MPO activity and DNA adduct levels in bronchoalveolar lavages of smokers
    Frederik J Van Schooten
    Department of Health Risk Analysis and Toxicology, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 13:828-33. 2004
    The myeloperoxidase (MPO) -463G-->A genetic polymorphism is associated with a reduced risk for lung cancer, but the underlying mechanism is not yet elucidated...
  57. ncbi Gender and smoking-related risk reduction of periodontal disease with variant myeloperoxidase alleles
    P Meisel
    Department of Pharmacology, Ernst Moritz Arndt University Greifswald, Germany
    Genes Immun 3:102-6. 2002
    b>Myeloperoxidase (MPO) is an oxidative enzyme expressed in polymorphonuclear leukocytes. It is involved in the defence against periodontal bacteria, and is also able to mediate inflammatory tissue destruction in periodontal disease...
  58. ncbi Increased risk for Alzheimer disease with the interaction of MPO and A2M polymorphisms
    Mario Zappia
    Institute of Neurology, University Magna Graecia, Catanzaro, Italy
    Arch Neurol 61:341-4. 2004
    The genes encoding myeloperoxidase (MPO) and alpha(2)-macroglobulin (A2M) are involved in molecular pathways leading to beta-amyloid deposition...
  59. ncbi MPO and APOEepsilon4 polymorphisms interact to increase risk for AD in Finnish males
    W F Reynolds
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Neurology 55:1284-90. 2000
    b>Myeloperoxidase (MPO) is present in senile plaques and surrounding reactive microglia, but not in normal brain parenchyma. MPO in plaques is highest in APOE epsilon4 carriers, suggesting a functional interaction...
  60. ncbi Myeloperoxidase polymorphism related to cardiovascular events in coronary artery disease
    Folkert W Asselbergs
    Am J Med 116:429-30. 2004
  61. ncbi Genetic polymorphisms of MPO, COMT, MnSOD, NQO1, interactions with environmental exposures and bladder cancer risk
    Rayjean J Hung
    International Agency of Research on Cancer, Lyon 69008, France
    Carcinogenesis 25:973-8. 2004
    ..Several enzymes, which play key roles in oxidative stress are polymorphic in humans. Myeloperoxidase (MPO) produces a strong oxidant for microbicidal activity, and activates carcinogens in tobacco smoke...
  62. pmc Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer disease
    Richard A Maki
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    J Biol Chem 284:3158-69. 2009
    b>Myeloperoxidase (MPO) is expressed in Alzheimer disease (AD) but not normal aged brain. A functional -463G/A MPO promoter polymorphism has been associated with AD risk through as yet unidentified mechanisms...
  63. ncbi MPO and SOD2 polymorphisms, gender, and the risk of non-small cell lung carcinoma
    Geoffrey Liu
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Lett 214:69-79. 2004
    Manganese superoxide dismutase (SOD2) and myeloperoxidase (MPO) are polymorphic enzymes involved in reactive oxidative species metabolism...
  64. ncbi Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase
    Stephan Baldus
    Department of Cardiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Circulation 113:1871-8. 2006
    Neutrophils and monocytes are centrally linked to vascular inflammatory disease, and leukocyte-derived myeloperoxidase (MPO) has emerged as an important mechanistic participant in impaired vasomotor function...
  65. ncbi Myeloperoxidase, a leukocyte-derived vascular NO oxidase
    Jason P Eiserich
    Department of Internal Medicine, Division of Nephrology, University of California, Davis, CA 95616, USA
    Science 296:2391-4. 2002
    b>Myeloperoxidase (MPO) is an abundant mammalian phagocyte hemoprotein thought to primarily mediate host defense reactions...
  66. ncbi Association of the polymorphisms of MTHFR C677T, VDR C352T, and MPO G463A with risk for esophageal squamous cell dysplasia and carcinoma
    Daqing Li
    Qilu Hospital, Shandong University, Jinan, China
    Arch Med Res 39:594-600. 2008
    ..samples to evaluate the association of polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T, vitamin D receptor (VDR) C352T, and myeloperoxidase (MPO) G463A genotypes with esophageal squamous cell dysplasia and carcinoma.
  67. ncbi Association between Alzheimer's disease and a functional polymorphism in the Myeloperoxidase gene
    F C Crawford
    Roskamp Institute and the University of South Florida Memory Disorder Clinic, 3515 East Fletcher Avenue, Tampa, Florida 33613, USA
    Exp Neurol 167:456-9. 2001
    A polymorphism in the Myeloperoxidase gene (MPO) has previously been demonstrated to be associated with gender-specific risk in an Alzheimer's Disease (AD) autopsy sample...
  68. ncbi Association of apolipoprotein E and myeloperoxidase genotypes to clinical course of familial and sporadic multiple sclerosis
    B Zakrzewska-Pniewska
    Department of Neurology, The Medical University of Warsaw, 02 097 Warsaw, Banacha 1a, Str, Poland
    Mult Scler 10:266-71. 2004
    The importance of apolipoprotein E (ApoE) and myeloperoxidase (MPO) genotypes in the clinical characteristics of multiple sclerosis (MS) has been recently emphasized...
  69. ncbi Interrogation of heme pocket environment of mammalian peroxidases with diatomic ligands
    H M Abu-Soud
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Biochemistry 40:10747-55. 2001
    Recent studies demonstrate that myeloperoxidase (MPO), eosinophil peroxidase (EPO), and lactoperoxidase (LPO), homologous members of the mammalian peroxidase superfamily, can all serve as catalysts for generating nitric oxide- (nitrogen ..
  70. ncbi Subcellular distribution of urokinase and urokinase receptor in human neutrophils determined by immunoelectron microscopy
    T L Pedersen
    Department of Pathology, Herlev Hospital, University of Copenhagen, Denmark
    Ultrastruct Pathol 24:175-82. 2000
    ..matrix metalloproteinase type-9 (MMP-9) for gelatinase granules, lactoferrin (LF) for specific granules, and myeloperoxidase (MPO) and neutrophil elastase (NE) for primary granules...
  71. ncbi Biochemical and physiological alterations in canine neutrophils separated by lysis or Percoll gradient isolation technologies
    D F Gruber
    Experimental Hematology Department, Armed Forces Radiobiology, Research Institute, Bethesda, Maryland 20814-5145
    Immunopharmacol Immunotoxicol 12:93-104. 1990
    ..Cellular isolation methods did not significantly alter cellular myeloperoxidase (MPO) levels based on comparisons of cellular totals...
  72. pmc Improved survival and reversal of endothelial dysfunction by the 21-aminosteroid, U-74389G in splanchnic ischaemia-reperfusion injury in the rat
    F Squadrito
    Institute of Pharmacology, School of Medicine, University of Messina, Italy
    Br J Pharmacol 115:395-400. 1995
    ..TNF-alpha), white blood cell (WBC) count, mean arterial blood pressure (MAP), plasma malonyladehyde (MAL); myeloperoxidase activity (MPO) and the responsiveness to acetylcholine (ACh 10 nM-10 microM) of aortic rings were ..
  73. ncbi Ameliorative effects of sodium ferulate on experimental colitis and their mechanisms in rats
    Wei Guo Dong
    Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, Hubei Province, China
    World J Gastroenterol 9:2533-8. 2003
    ..To investigate the ameliorative effects of sodium ferulate (SF) on acetic acid-induced colitis and their mechanisms in rats...
  74. ncbi Andalusol, a diterpenoid with anti-inflammatory activity from Siderits foetens Clemen
    A Navarro
    , Facultad de Farmacia, Universidad Complutense de Madrid, Spain
    Z Naturforsch C 52:844-9. 1997
    ..Quantitation of the neutrophil specific marker, myeloperoxidase (MPO), demonstrated that its topical anti-inflammatory effect was associated with reduction in neutrophil ..
  75. ncbi [Myeloperoxidase, lactoferrin and elastase in bronchoalveolar lavage and plasma in pneumonia]
    J Braun
    ,
    Pneumologie 46:141-7. 1992
    ..bronchoalveolar lavage (BALF) and in plasma, the concentration of the locally produced granulocyte products myeloperoxidase (MPO), lactoferrin (LF) and elastase-alpha 1 proteinase complex (ELA) as well as of the alpha 1 proteinase ..
  76. ncbi Myelopoietin, a chimeric agonist of human interleukin 3 and granulocyte colony-stimulating factor receptors, mobilizes CD34+ cells that rapidly engraft lethally x-irradiated nonhuman primates
    T J MacVittie
    Greenebaum Cancer Center, Baltimore, MD 21201, USA
    Exp Hematol 27:1557-68. 1999
    ....
  77. ncbi Study of the topical anti-inflammatory activity of Achillea ageratum on chronic and acute inflammation models
    M A Gomez
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Sevilla, Spain
    Z Naturforsch C 54:937-41. 1999
    ....
  78. pmc 15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury
    Driss El Kebir
    Research Center, Maisonneuve Rosemont Hospital, Montreal, Quebec
    Am J Respir Crit Care Med 180:311-9. 2009
    ..b>Myeloperoxidase (MPO), abundantly expressed in neutrophils, not only generates cytotoxic oxidants but also signals through ..
  79. ncbi Nitrite enhances neutrophil-induced DNA strand breakage in pulmonary epithelial cells by inhibition of myeloperoxidase
    Ad M Knaapen
    Department of Health Risk Analysis and Toxicology, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Carcinogenesis 26:1642-8. 2005
    ..that nitrite may affect the toxicity of neutrophils, involving an interaction with neutrophil-derived myeloperoxidase (MPO)...
  80. pmc Contribution of intercellular adhesion molecule 1 (ICAM-1) to the pathogenesis of splanchnic artery occlusion shock in the rat
    F Squadrito
    Institute of Pharmacology, School of Medicine, University of Messina, Italy
    Br J Pharmacol 113:912-6. 1994
    ..serum tumour necrosis factor-alpha (TNF-alpha), white blood cell (WBC) count, mean arterial blood pressure, myeloperoxidase activity (MPO; studied as a quantitative means to assess leukocyte accumulation) and the responsiveness to ..
  81. ncbi Pancreatic phospholipase A2 induces bacterial translocation in rats
    H Hongo
    First Department of Medicine, Kyoto Prefectural University of Medicine, Japan
    Immunopharmacol Immunotoxicol 21:717-26. 1999
    ....
  82. ncbi [A case of fluminant septic shock due to Streptococcus agalactiae in a patient with MPO-ANCA related glomerulonephritis]
    A Tanaka
    Department of Nephrology, Saiseikai Nakatsu Hospital, Osaka, Japan
    Kansenshogaku Zasshi 70:1186-9. 1996
    ..S. agalactiae was isolated from the blood. Autopsy revealed bilateral bronchopneumonia and shock liver. To our knowledge, this is the first report of septic shock caused by S. agalactiae...
  83. ncbi Circular permutation of the granulocyte colony-stimulating factor receptor agonist domain of myelopoietin
    C A McWherter
    Searle Discovery Research, Monsanto Company, St Louis, Missouri 63198, USA
    Biochemistry 38:4564-71. 1999
    ..It was found that circular permutation of the G-CSF domain can alter the ratio of G-CSFR:IL-3R agonist activities, demonstrating that it is a useful tool in engineering chimeric proteins with therapeutic potential...
  84. pmc Investigation of mechanism(s) of DNA damage induced by 4-monochlorobiphenyl (PCB3) metabolites
    Wei Xie
    Department of Occupational and Environmental Health, University of Iowa, College of Public Health, Iowa City, Iowa 52242, USA
    Environ Int 36:950-61. 2010
    ..To examine this hypothesis, we employed two cell lines with different myeloperoxidase (MPO) activities, MPO-rich HL-60 and MPO-deficient Jurkat cells, and measured cytotoxicity, DNA damage (COMET ..
  85. ncbi [Study on pathogenetic role of myeloperoxidase, tumor necrosis factor alpha, interferon gamma in chronic airway infection with Pseudomonas aeruginosa]
    H Takeda
    First Department of Internal Medicine, Kyorin University, School of Medicine
    Kansenshogaku Zasshi 72:395-409. 1998
    ..aeruginosa...
  86. ncbi [Effects of N-acetylcysteine on mRNA expression of monocyte chemotactic protein and macrophage inflammatory protein 2 in acute necrotizing pancreatitis: experiment with rats]
    Chun Fang Xu
    Department of Gastroenterology, First Affiliated Hospital of Soochow University, Suzhou 215006, China
    Zhonghua Yi Xue Za Zhi 88:711-5. 2008
    ....
  87. ncbi Healing process induced by a flavonic fraction of Bidens aurea on chronic gastric lesion in rat. Role of angiogenesis and neutrophil inhibition
    M Martin Calero
    Laboratorio de Farmacologia, Facultad de Farmacia, Universidad de Sevilla, Espana
    Z Naturforsch C 51:570-7. 1996
    ..b>Myeloperoxidase (MPO) activity was assayed and used as an index of leucocyte infiltration...
  88. ncbi Endocytosis of microperoxidase in the marginal cells of stria vascularis
    Akinobu Kakigi
    Department of Otolaryngology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Auris Nasus Larynx 34:39-43. 2007
    ..We investigated the basic properties of endocytosis in the marginal cells of stria vascularis (SV) to discuss whether marginal cells have a potential to maintain the endolymph homeostasis...
  89. ncbi Analysis of MPO-ANCA subtypes in a patient with propylthiouracil-induced vasculitis with multiple complications
    K Ohta
    Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan
    Clin Nephrol 68:315-21. 2007
    ..We report a 16 year-old girl with propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-positive glomerulonephritis combined with Henoch-Schönlein purpura nephritis (HSPN) and antiphospholipid syndrome (APS)...
  90. ncbi Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation
    Y Bilsel
    Department of General Surgery, Istanbul Medical Faculty, Istanbul, Turkey
    Dig Surg 19:306-11; discussion 311-2. 2002
    ..Another aspect of the study was to find out whether these substances have any effect on nitric oxide (NO) and free radical production...
  91. pmc Protection of Veratrum nigrum L. var. ussuriense Nakai alkaloids against ischemia-reperfusion injury of the rat liver
    Zhen Zhen Wang
    Department of Pharmacology, Dalian Medical University, Dalian 116027, Liaoning Province, China
    World J Gastroenterol 13:564-71. 2007
    ..To investigate the protective effects and possible mechanisms of Veratrum nigrum L.var. ussuriense Nakai alkaloids (VnA) on hepatic ischemia/reperfusion (I/R) injury in rats...
  92. ncbi The effects of chronic exposure to ethanol and cigarette smoke on the formation of peroxynitrite, level of nitric oxide, xanthine oxidase and myeloperoxidase activities in rat kidney
    Yilmaz Cigremis
    Department of Biology, Faculty of Art and Science, Kafkas University, 36100, Kars, Turkey
    Mol Cell Biochem 291:127-38. 2006
    ..The animals were killed and the kidneys were removed to determine the activity of xanthine oxidase (XO), myeloperoxidase (MPO) and the levels of nitric oxide (NO)...
  93. ncbi Analytical and diagnostic accuracy of the EliA automated enzyme fluoroimmunoassay for antineutrophil cytoplasmic autoantibody detection
    Danilo Villalta
    Immunologia Clinica e Virologia, Azienda Ospedaliera Santa Maria degli Angeli, Via Montereale 24, 33170 Pordenone, Italy
    Clin Chem Lab Med 42:1161-7. 2004
    Anti-proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCA) and anti-myeloperoxidase antibodies (MPO-ANCA) are considered important serological markers for several forms of idiopathic systemic vasculitis...
  94. doi Clinical significance of a myeloperoxidase gene polymorphism and inducible nitric oxide synthase expression in cirrhotic patients with hepatopulmonary syndrome
    Yanying Wang
    Department of Gastroenterology, Heilongjiang Provincial Hospital, Harbin, 150036, China
    J Huazhong Univ Sci Technolog Med Sci 30:437-42. 2010
    The clinical significance of a myeloperoxidase (MPO) gene polymorphism and inducible nitric oxide synthase (iNOS) expression in cirrhotic patients with hepatopulmonary syndrome (HPS) was explored...
  95. ncbi Plasma myeloperoxidase, NT-proBNP, and troponin-I in patients on CAPD compared with those on regular hemodialysis
    Abdulla Al-Hweish
    Department of Internal Medicine, King Fahd University Hospital, Al Khobar, Saudi Arabia
    Hemodial Int 14:308-15. 2010
    b>Myeloperoxidase (MPO) is a hemoprotein that is released during inflammation and may lead to irreversible protein and lipid modification, increasing levels of oxidized low density lipoprotein, and promoting athrogenesis...
  96. pmc Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis
    Arno G Siraki
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Dr, Research Triangle Park, NC 27709, USA
    Chem Res Toxicol 21:1143-53. 2008
    ..Here, we have investigated the metabolism of PA by myeloperoxidase (MPO) and the formation of an MPO protein free radical...
  97. pmc Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis
    Arno G Siraki
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 20:1038-45. 2007
    ..We have investigated the metabolism of AG by myeloperoxidase (MPO) and the formation of an MPO protein free radical...
  98. ncbi Phosphatidylinositol 3-kinase controls antineutrophil cytoplasmic antibodies-induced respiratory burst in human neutrophils
    Ralph Kettritz
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Wiltbergstrasse 50, 13122 Berlin, Germany
    J Am Soc Nephrol 13:1740-9. 2002
    ..TNF-alpha-primed PMN were stimulated with a monoclonal antibody to myeloperoxidase (MPO) and with PR3- and MPO-ANCA, respectively. Akt activation was assessed with phospho-specific antibodies...
  99. ncbi Pulmonary fibrosis in myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitides
    Sakae Homma
    Division of Respiratory Diseases, Toranomon Hospital and Okinaka Memorial Institute for Medical Research, Tokyo, Japan
    Respirology 9:190-6. 2004
    The association of pulmonary fibrosis (PF) with myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitides has not been well documented...
  100. doi Prolonged infections associated with antineutrophil cytoplasmic antibodies specific to proteinase 3 and myeloperoxidase: diagnostic and therapeutic challenge
    Branka Bonaci-Nikolic
    Institute of Allergy and Clinical Immunology, Clinical Center of Serbia, Belgrade, Serbia
    Clin Rheumatol 29:893-904. 2010
    ..markers may help in the diagnosis and the prognosis of infections associated with proteinase 3 (PR3) and myeloperoxidase (MPO)-ANCA. In this study (1993-2008)--with an average follow-up of 5...

Research Grants118 found, 100 shown here

  1. Arsenic Trioxide and Acute Myeloid Leukemia
    Yongkui Jing; Fiscal Year: 2005
    ..amounts of glutathione-s-transferase pi (GSTpi), glutathione peroxidase (GPx), catalase and high amounts of myeloperoxidase (MPO); 2) APL cells were highly sensitive to As2O3-induced apoptosis in vitro by a hydrogen peroxide (H2O2) ..
  2. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2010
    ..While generally attributed to the phagocyte-specific enzyme myeloperoxidase (MPO), it is unclear whether a peroxidase other than MPO in vascular wall plays a role in atherogenesis...
  3. Dual Function of VPO1 in Pathogen Recognition and Killing
    Guangjie Cheng; Fiscal Year: 2013
    ....
  4. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2009
    ..While generally attributed to the phagocyte-specific enzyme myeloperoxidase (MPO), it is unclear whether a peroxidase other than MPO in vascular wall plays a role in atherogenesis...
  5. Mechanisms and Prevention of Etoposide-Induced Leukemia
    Jack Yalowich; Fiscal Year: 2009
    ..The central hypothesis is that redox cycling of the phenolic anticancer agent etoposide (VP-16) by myeloperoxidase (MPO) found in myeloid progenitors amplifies the genotoxicity and carcinogenicity of this DNA topoisomerase ..
  6. Angiotensin II, oxidative stress and aneurysm formation
    Neal L Weintraub; Fiscal Year: 2013
    ..are capable of inducing vascular oxidant stress and potentially contributing to AAA, we hypothesis that myeloperoxidase (MPO) is instrumental in this process...
  7. Human neutrophils, phospholipase A2 and S.aureus: microbial targets and responses
    WILLIAM NAUSEEF; Fiscal Year: 2009
    ..Importantly, hydrogen peroxide (H2O2) produced by PMN is amplified by the PMN granule protein myeloperoxidase (MPO) to generate HOCl (bleach)...
  8. Human neutrophils, phospholipase A2 and S.aureus: microbial targets and responses
    William M Nauseef; Fiscal Year: 2013
    ..Importantly, hydrogen peroxide (H2O2) produced by PMN is amplified by the PMN granule protein myeloperoxidase (MPO) to generate HOCl (bleach)...
  9. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..Inflammatory markers and markers of oxidative stress, including interleukin (IL)-6, -8 and -10, myeloperoxidase (MPO), and matrix metalloproteinase-9 (MMP-9) will be analyzed in induced sputum...
  10. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    Kirkwood A Pritchard; Fiscal Year: 2013
    ..of HDL and therefore HDL function and if targeting oxidative stress induced by 1) xanthine oxidase (XO);2) myeloperoxidase (MPO);3) cell free hemoglobin (Hb);and, 4) oxidized lipids prevents oxidation of HDL and other lipoproteins ..
  11. DNA Repair Capacity and Risk of Pre-malignant Lesion in Lung Epithelium
    Hua Zhao; Fiscal Year: 2009
    ..neutrophils, including induction of oxidative DNA damage through release of reactive oxygen species (ROS) and myeloperoxidase (MPO)-related metabolic activation of chemical carcinogens, is a crucial etiological factor in this ..
  12. Characterization of Salmonella typhimurium-induced NET formation
    Josely F Figueiredo; Fiscal Year: 2013
    ..NET formation involves extracellular release of chromatin and associated proteins, such as elastase and myeloperoxidase (MPO), which are released from primary granules...
  13. CFTR Expression and Function in Human Neutrophils
    Guoshun Wang; Fiscal Year: 2007
    ..main phagocytes responsible for elimination of pathogens and cell debris, synthesize and maintain abundant myeloperoxidase (MPO)...
  14. CFTR Expression and Function in Human Neutrophils
    Guoshun Wang; Fiscal Year: 2010
    ..main phagocytes responsible for elimination of pathogens and cell debris, synthesize and maintain abundant myeloperoxidase (MPO)...
  15. CFTR Expression and Function in Human Neutrophils
    Guoshun Wang; Fiscal Year: 2009
    ..main phagocytes responsible for elimination of pathogens and cell debris, synthesize and maintain abundant myeloperoxidase (MPO)...
  16. Anti-myeloperoxidase autoantibody response
    PATRICK NACHMAN; Fiscal Year: 2001
    An anti-neutrophil cytoplasmic antibodies (ANCA), directed toward myeloperoxidase (MPO) and proteinase 3 (PR3), are detected in the majority of patients with pauci-immune necrotizing glomerulonephritis and small vessel vasculitis...
  17. Anti-myeloperoxidase autoantibody response
    PATRICK NACHMAN; Fiscal Year: 2000
    An anti-neutrophil cytoplasmic antibodies (ANCA), directed toward myeloperoxidase (MPO) and proteinase 3 (PR3), are detected in the majority of patients with pauci-immune necrotizing glomerulonephritis and small vessel vasculitis...
  18. Anti-myeloperoxidase autoantibody response
    PATRICK NACHMAN; Fiscal Year: 2002
    An anti-neutrophil cytoplasmic antibodies (ANCA), directed toward myeloperoxidase (MPO) and proteinase 3 (PR3), are detected in the majority of patients with pauci-immune necrotizing glomerulonephritis and small vessel vasculitis...
  19. Anti-myeloperoxidase autoantibody response
    PATRICK NACHMAN; Fiscal Year: 2002
    An anti-neutrophil cytoplasmic antibodies (ANCA), directed toward myeloperoxidase (MPO) and proteinase 3 (PR3), are detected in the majority of patients with pauci-immune necrotizing glomerulonephritis and small vessel vasculitis...
  20. Anti-myeloperoxidase autoantibody response
    PATRICK NACHMAN; Fiscal Year: 2002
    An anti-neutrophil cytoplasmic antibodies (ANCA), directed toward myeloperoxidase (MPO) and proteinase 3 (PR3), are detected in the majority of patients with pauci-immune necrotizing glomerulonephritis and small vessel vasculitis...
  21. Zebrafish Genetics to Identify Genes Involved in Hematopoiesis
    DHVANIT INDRAVADAN SHAH; Fiscal Year: 2013
    ..The appeal and the potential of future outcomes of this project satisfy the objectives of NIDDK sponsored Mentored Scientist Development Award (K01) mechanism. ..
  22. Zebrafish Genetics to Identify Genes Involved in Hematopoiesis
    DHVANIT INDRAVADAN SHAH; Fiscal Year: 2013
    ..The appeal and the potential of future outcomes of this project satisfy the objectives of NIDDK sponsored Mentored Scientist Development Award (K01) mechanism. ..
  23. EPIDEMIOLOGY OF INFANT LEUKEMIA
    Julie Ross; Fiscal Year: 2007
    ..This study will utilize the unique resources available through the Children's Oncology Group, and include ascertainment of cases over a four-year period (Jan 1, 2003-Dec 31, 2006). ..
  24. EPIDEMIOLOGY OF INFANT LEUKEMIA
    Julie Ross; Fiscal Year: 2004
    ..This study will utilize the unique resources available through the Children's Oncology Group, and include ascertainment of cases over a four-year period (Jan 1, 2003-Dec 31, 2006). ..
  25. EPIDEMIOLOGY OF INFANT LEUKEMIA
    Julie Ross; Fiscal Year: 2005
    ..This study will utilize the unique resources available through the Children's Oncology Group, and include ascertainment of cases over a four-year period (Jan 1, 2003-Dec 31, 2006). ..
  26. EPIDEMIOLOGY OF INFANT LEUKEMIA
    Julie Ross; Fiscal Year: 2006
    ..This study will utilize the unique resources available through the Children's Oncology Group, and include ascertainment of cases over a four-year period (Jan 1, 2003-Dec 31, 2006). ..
  27. The role of neutrophil recruitment in arterial diseases
    Yuqing Huo; Fiscal Year: 2013
    ..mice, mice in which the expression of Cre recombinase and EGFP are driven by the regulatory region of the myeloperoxidase (MPO) gene (MPO-Cre mice)...
  28. Biophysics of HDL Dysfunction
    Mary G Sorci-Thomas; Fiscal Year: 2013
    ..anti- and pro-inflammatory enzymes (paraoxonase [PON1], platelet activating factor acetylhydrolase [PAF-AH], myeloperoxidase [MPO] and xanthine oxidase [XO]) to prevent LDL oxidation;2) or ATP binding cassette (ABC) transporter 1 (..
  29. ANTI-INFLAMMATORY ACTIVITY OF DAPSONE
    PAULA BOZEMAN; Fiscal Year: 1990
    ..b>Myeloperoxidase (MPO), an enzyme found in the granules of neutrophils and monocytes, catalyzes the oxidation of chloride (Cl-)..
  30. Arsenic Trioxide and Acute Myeloid Leukemia
    Yongkui Jing; Fiscal Year: 2002
    ..amounts of glutathione-s-transferase pi (GSTpi), glutathione peroxidase (GPx), catalase and high amounts of myeloperoxidase (MPO); 2) APL cells were highly sensitive to As2O3-induced apoptosis in vitro by a hydrogen peroxide (H2O2) ..
  31. Arsenic Trioxide and Acute Myeloid Leukemia
    Yongkui Jing; Fiscal Year: 2004
    ..amounts of glutathione-s-transferase pi (GSTpi), glutathione peroxidase (GPx), catalase and high amounts of myeloperoxidase (MPO); 2) APL cells were highly sensitive to As2O3-induced apoptosis in vitro by a hydrogen peroxide (H2O2) ..
  32. Arsenic Trioxide and Acute Myeloid Leukemia
    Yongkui Jing; Fiscal Year: 2003
    ..amounts of glutathione-s-transferase pi (GSTpi), glutathione peroxidase (GPx), catalase and high amounts of myeloperoxidase (MPO); 2) APL cells were highly sensitive to As2O3-induced apoptosis in vitro by a hydrogen peroxide (H2O2) ..
  33. In vitro studies of ANCA glomerulonephritis pathogenesis
    J Jennette; Fiscal Year: 2000
    ..g. of chemokines and cytokines, and their receptors. ..
  34. Molecular Imaging Probes for Reporting on Vascular Oxidative Response
    Alexei A Bogdanov; Fiscal Year: 2013
    ..b>Myeloperoxidase (MPO, one of the components released by PMNs via triggered exocytosis) is a unique catalytically active ..
  35. Molecular Imaging Probes for Reporting on Vascular Oxidative Response
    Alexei A Bogdanov; Fiscal Year: 2010
    ..b>Myeloperoxidase (MPO, one of the components released by PMNs via triggered exocytosis) is a unique catalytically active ..
  36. MYLEOPEROXIDASE AND LEUKOCYTE GRANULE COMPONENTS
    EDWIN THOMAS; Fiscal Year: 1991
    Stimulation of neutrophilic leukocytes results in secretion of toxic proteins and the enzyme myeloperoxidase (MPO) from cytoplasmic granules and activates neutrophil oxygen (O2) metabolism, which produces toxic oxidants...
  37. MYELOPEROXIDASE AND LEUKOCYTE GRANULE COMPONENTS
    EDWIN THOMAS; Fiscal Year: 1990
    Stimulation of neutrophilic leukocytes results in secretion of toxic proteins and the enzyme myeloperoxidase (MPO) from cytoplasmic granules and activates neutrophil oxygen (O2) metabolism, which produces toxic oxidants...
  38. ANCA GLOMERULONEPHRITIS: FROM MOLECULES TO MAN
    Ronald Falk; Fiscal Year: 2002
    ..evaluation of basic molecular and clinical immunological and epidemiological studies pertaining to both anti-myeloperoxidase (MPO) and proteinase 3 (PR3) autoimmune response...
  39. ANCA GLOMERULONEPHRITIS: FROM MOLECULES TO MAN
    Ronald Falk; Fiscal Year: 2003
    ..evaluation of basic molecular and clinical immunological and epidemiological studies pertaining to both anti-myeloperoxidase (MPO) and proteinase 3 (PR3) autoimmune response...
  40. ANCA GLOMERULONEPHRITIS: FROM MOLECULES TO MAN
    Ronald Falk; Fiscal Year: 2003
    ..evaluation of basic molecular and clinical immunological and epidemiological studies pertaining to both anti-myeloperoxidase (MPO) and proteinase 3 (PR3) autoimmune response...
  41. ANCA GLOMERULONEPHRITIS: FROM MOLECULES TO MAN
    Ronald Falk; Fiscal Year: 2003
    ..evaluation of basic molecular and clinical immunological and epidemiological studies pertaining to both anti-myeloperoxidase (MPO) and proteinase 3 (PR3) autoimmune response...
  42. ANCA GLOMERULONEPHRITIS: FROM MOLECULES TO MAN
    Ronald Falk; Fiscal Year: 2004
    ..evaluation of basic molecular and clinical immunological and epidemiological studies pertaining to both anti-myeloperoxidase (MPO) and proteinase 3 (PR3) autoimmune response...
  43. ANCA GLOMERULONEPHRITIS: FROM MOLECULES TO MAN
    Ronald Falk; Fiscal Year: 2001
    ..evaluation of basic molecular and clinical immunological and epidemiological studies pertaining to both anti-myeloperoxidase (MPO) and proteinase 3 (PR3) autoimmune response...
  44. ANCA GLOMERULONEPHRITIS: FROM MOLECULES TO MAN
    Ronald Falk; Fiscal Year: 2002
    ..evaluation of basic molecular and clinical immunological and epidemiological studies pertaining to both anti-myeloperoxidase (MPO) and proteinase 3 (PR3) autoimmune response...
  45. ANCA GLOMERULONEPHRITIS: FROM MOLECULES TO MAN
    Ronald Falk; Fiscal Year: 2000
    ..evaluation of basic molecular and clinical immunological and epidemiological studies pertaining to both anti-myeloperoxidase (MPO) and proteinase 3 (PR3) autoimmune response...
  46. ANCA GLOMERULONEPHRITIS: FROM MOLECULES TO MAN
    Ronald Falk; Fiscal Year: 2002
    ..evaluation of basic molecular and clinical immunological and epidemiological studies pertaining to both anti-myeloperoxidase (MPO) and proteinase 3 (PR3) autoimmune response...
  47. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    KIRKWOOD A contact PRITCHARD; Fiscal Year: 2010
    ..of HDL and therefore HDL function and if targeting oxidative stress induced by 1) xanthine oxidase (XO);2) myeloperoxidase (MPO);3) cell free hemoglobin (Hb);and, 4) oxidized lipids prevents oxidation of HDL and other lipoproteins ..
  48. NEUTROPHIL AUTOANTIBODIES IN VASCULITIS AND NEPHRITIS
    Ronald Falk; Fiscal Year: 1999
    ....
  49. NEUTROPHIL AUTOANTIBODIES IN VASCULITIS AND NEPHRITIS
    Ronald Falk; Fiscal Year: 2000
    ....
  50. Molecular characterization of human ANCA and antigen
    Ronald Falk; Fiscal Year: 2000
    ..We reported the association of ANCA with necrotizing glomerulonephritis (GN) in 1988 and recognized myeloperoxidase (MPO)-ANCA...
  51. MYELOPEROXIDASE, OXIDANT STRESS AND ATHEROGENESIS
    Stanley Hazen; Fiscal Year: 2002
    ..This proposal focuses on oxidation reactions catalyzed by myeloperoxidase (MPO) and the potential utility of protein oxidation products of distinct oxidation pathways to serve as non-..
  52. MYELOPEROXIDASE, OXIDANT STRESS AND ATHEROGENESIS
    Stanley Hazen; Fiscal Year: 1999
    ..This proposal focuses on oxidation reactions catalyzed by myeloperoxidase (MPO) and the potential utility of protein oxidation products of distinct oxidation pathways to serve as non-..
  53. MYELOPEROXIDASE, OXIDANT STRESS AND ATHEROGENESIS
    Stanley Hazen; Fiscal Year: 2001
    ..This proposal focuses on oxidation reactions catalyzed by myeloperoxidase (MPO) and the potential utility of protein oxidation products of distinct oxidation pathways to serve as non-..
  54. MYELOPEROXIDASE, OXIDANT STRESS AND ATHEROGENESIS
    Stanley Hazen; Fiscal Year: 2000
    ..This proposal focuses on oxidation reactions catalyzed by myeloperoxidase (MPO) and the potential utility of protein oxidation products of distinct oxidation pathways to serve as non-..
  55. MYELOPEROXIDASE, OXIDANT STRESS AND ATHEROGENESIS
    Stanley Hazen; Fiscal Year: 2001
    ..This proposal focuses on oxidation reactions catalyzed by myeloperoxidase (MPO) and the potential utility of protein oxidation products of distinct oxidation pathways to serve as non-..
  56. Regulation of Myeloperoxidase Catalysis by Nitric Oxide
    HUSAM ABU SOUD; Fiscal Year: 2004
    b>Myeloperoxidase (MPO) is abundant hemoprotein present in neutrophils and monocytes which plays an essential role in immune surveillance and host defense mechanisms...
  57. Regulation of Myeloperoxidase Catalysis by Nitric Oxide
    HUSAM ABU SOUD; Fiscal Year: 2002
    b>Myeloperoxidase (MPO) is abundant hemoprotein present in neutrophils and monocytes which plays an essential role in immune surveillance and host defense mechanisms...
  58. Regulation of Myeloperoxidase Catalysis by Nitric Oxide
    HUSAM ABU SOUD; Fiscal Year: 2002
    b>Myeloperoxidase (MPO) is abundant hemoprotein present in neutrophils and monocytes which plays an essential role in immune surveillance and host defense mechanisms...
  59. Regulation of Myeloperoxidase Catalysis by Nitric Oxide
    HUSAM ABU SOUD; Fiscal Year: 2003
    b>Myeloperoxidase (MPO) is abundant hemoprotein present in neutrophils and monocytes which plays an essential role in immune surveillance and host defense mechanisms...
  60. Regulation of Myeloperoxidase Catalysis by Nitric Oxide
    HUSAM ABU SOUD; Fiscal Year: 2001
    b>Myeloperoxidase (MPO) is abundant hemoprotein present in neutrophils and monocytes which plays an essential role in immune surveillance and host defense mechanisms...
  61. Angiotensin II, oxidative stress and aneurysm formation
    Neal L Weintraub; Fiscal Year: 2010
    ..are capable of inducing vascular oxidant stress and potentially contributing to AAA, we hypothesis that myeloperoxidase (MPO) is instrumental in this process...
  62. MPO and NO signaling in neointima formation
    Chunxiang Zhang; Fiscal Year: 2010
    ..b>Myeloperoxidase (MPO) is a leukocyte-derived heme protein...
  63. MPO and NO signaling in neointima formation
    Chunxiang Zhang; Fiscal Year: 2007
    ..b>Myeloperoxidase (MPO) is a leukocyte-derived heme protein...
  64. MPO and NO signaling in neointima formation
    Chunxiang Zhang; Fiscal Year: 2006
    ..b>Myeloperoxidase (MPO) is a leukocyte-derived heme protein...
  65. MPO and NO signaling in neointima formation
    Chunxiang Zhang; Fiscal Year: 2009
    ..b>Myeloperoxidase (MPO) is a leukocyte-derived heme protein...
  66. MPO and NO signaling in neointima formation
    Chunxiang Zhang; Fiscal Year: 2007
    ..b>Myeloperoxidase (MPO) is a leukocyte-derived heme protein...
  67. Oxidative Stress Related Gene Polymorphisms in Acute kidney Injury
    MARY PERIANAYAGAM; Fiscal Year: 2009
    ..SNPs) of genes encoding pro-oxidant enzymes that promote tissue injury, namely NADPH oxidase (p22phox) and myeloperoxidase (MPO), and anti-oxidant enzymes that promote tissue repair, namely catalase and glutathione peroxidase-1 (GPx-..
  68. Oxidative Stress Related Gene Polymorphisms in Acute kidney Injury
    Mary C Perianayagam; Fiscal Year: 2010
    ..SNPs) of genes encoding pro-oxidant enzymes that promote tissue injury, namely NADPH oxidase (p22phox) and myeloperoxidase (MPO), and anti-oxidant enzymes that promote tissue repair, namely catalase and glutathione peroxidase-1 (GPx-..
  69. LIPID PEROXIDATION IN COLORECTAL CANCER
    Manuela Gago Dominguez; Fiscal Year: 2007
    ..1. To conduct a family-based case-control association study of oxidative stress-related genes, including myeloperoxidase (MPO), endothelial cell nitric oxide synthase (ecNOS), manganese superoxide dismutase (MnSOD), selenium-..
  70. LIPID PEROXIDATION IN COLORECTAL CANCER
    Manuela Gago Dominguez; Fiscal Year: 2006
    ..1. To conduct a family-based case-control association study of oxidative stress-related genes, including myeloperoxidase (MPO), endothelial cell nitric oxide synthase (ecNOS), manganese superoxide dismutase (MnSOD), selenium-..
  71. LIPID PEROXIDATION IN COLORECTAL CANCER
    Manuela Gago Dominguez; Fiscal Year: 2009
    ..1. To conduct a family-based case-control association study of oxidative stress-related genes, including myeloperoxidase (MPO), endothelial cell nitric oxide synthase (ecNOS), manganese superoxide dismutase (MnSOD), selenium-..
  72. Proinflammatory enzymes in amyotrophic lateral sclerosis
    Serge Przedborski; Fiscal Year: 2001
    ..mutant or wild-type SOD1 and, in transgenic SOD1G93A mice after ablation of neuronal NOS (nNOS), iNOS, or myeloperoxidase (MOP), which is the only mammalian enzyme which produced hypochlorous acid...
  73. Proinflammatory enzymes in amyotrophic lateral sclerosis
    Serge Przedborski; Fiscal Year: 2004
    ..mutant or wild-type SOD1 and, in transgenic SOD1G93A mice after ablation of neuronal NOS (nNOS), iNOS, or myeloperoxidase (MOP), which is the only mammalian enzyme which produced hypochlorous acid...
  74. Proinflammatory enzymes in amyotrophic lateral sclerosis
    Serge Przedborski; Fiscal Year: 2002
    ..mutant or wild-type SOD1 and, in transgenic SOD1G93A mice after ablation of neuronal NOS (nNOS), iNOS, or myeloperoxidase (MOP), which is the only mammalian enzyme which produced hypochlorous acid...
  75. Involvement of Myeloperoxidase in Atherosclerosis
    Wanda Reynolds; Fiscal Year: 2005
    Increasing evidence implicates myeloperoxidase (MPO) in oxidative damage leading to atherosclerosis...
  76. Proinflammatory enzymes in amyotrophic lateral sclerosis
    Serge Przedborski; Fiscal Year: 2003
    ..mutant or wild-type SOD1 and, in transgenic SOD1G93A mice after ablation of neuronal NOS (nNOS), iNOS, or myeloperoxidase (MOP), which is the only mammalian enzyme which produced hypochlorous acid...
  77. MPO oxidants in synucleinopathies
    Wanda F Reynolds; Fiscal Year: 2011
    ..Our studies suggest that myeloperoxidase (MPO) is a significant source of oxidants that promote misfolding and aggregation of a-syn, as well as ..
  78. Myeloperoxidase and NO signaling in the vasculature
    C White; Fiscal Year: 2002
    DESCRIPTION (provided by the applicant): The heme protein myeloperoxidase (MPO) plays an important role in the host defense response...
  79. Myeloperoxidase and NO signaling in the vasculature
    C White; Fiscal Year: 2001
    DESCRIPTION (provided by the applicant): The heme protein myeloperoxidase (MPO) plays an important role in the host defense response...
  80. Myeloperoxidase and NO signaling in the vasculature
    C White; Fiscal Year: 2003
    DESCRIPTION (provided by the applicant): The heme protein myeloperoxidase (MPO) plays an important role in the host defense response...
  81. Myeloperoxidase and NO signaling in the vasculature
    C White; Fiscal Year: 2002
    DESCRIPTION (provided by the applicant): The heme protein myeloperoxidase (MPO) plays an important role in the host defense response...
  82. Myeloperoxidase and NO signaling in the vasculature
    C White; Fiscal Year: 2004
    DESCRIPTION (provided by the applicant): The heme protein myeloperoxidase (MPO) plays an important role in the host defense response...
  83. A Novel Mitigator for Radiation Lung Injury
    Shanmin Yang; Fiscal Year: 2009
    ..in the BALF (bronchial alveolar lavage fluid), the lung infiltrated inflammatory cells and exudates and MPO (myeloperoxidase) activity, the plasma pro-inflammation cytokines, such as IL1, TNF, lymphotaxin, IL6, ICAM-1, P-selectin, and ..
  84. Zebrafish Genetics to Identify Genes Involved in Hematopoiesis
    DHVANIT INDRAVADAN SHAH; Fiscal Year: 2010
    ..The appeal and the potential of future outcomes of this project satisfy the objectives of NIDDK sponsored Mentored Scientist Development Award (K01) mechanism. ..
  85. Evaluation of sensory neuron plasticity following neonatal maternal separation
    JULIE A CARLSTEN CHRISTIANSON; Fiscal Year: 2010
    ..administered to induce colitis and a) the extent of inflammation will be determined by assessing increases in myeloperoxidase (MPO) activity and growth factor production, and b) VMR, single cell RT-PCR and calcium imaging will be ..
  86. A TRANSCRIPTIONAL PROGRAM REGULATING MYELOPOIESIS
    Alan Friedman; Fiscal Year: 2004
    ..Myelopoiesis at various levels of C/EBP activity and progenitor fate after various times of C/EBP inhibition will be assessed. ..
  87. A TRANSCRIPTIONAL PROGRAM REGULATING MYELOPOIESIS
    Alan Friedman; Fiscal Year: 2002
    ..Myelopoiesis at various levels of C/EBP activity and progenitor fate after various times of C/EBP inhibition will be assessed. ..
  88. A TRANSCRIPTIONAL PROGRAM REGULATING MYELOPOIESIS
    Alan Friedman; Fiscal Year: 2003
    ..Myelopoiesis at various levels of C/EBP activity and progenitor fate after various times of C/EBP inhibition will be assessed. ..
  89. A TRANSCRIPTIONAL PROGRAM REGULATING MYELOPOIESIS
    Alan Friedman; Fiscal Year: 2001
    ..Myelopoiesis at various levels of C/EBP activity and progenitor fate after various times of C/EBP inhibition will be assessed. ..
  90. Nitric Oxide-Mediated Oxidation/Nitration in Membranes
    Balaraman Kalyanaraman; Fiscal Year: 2010
    ..g., atherosclerosis, diabetes, Parkinson's and Lou Gehrig's). ..
  91. Nitric Oxide-Mediated Oxidation/Nitration in Membranes
    Balaraman Kalyanaraman; Fiscal Year: 2009
    ..g., atherosclerosis, diabetes, Parkinson's and Lou Gehrig's). ..
  92. In Vivo Mechanisms of Vascular Dysfunction in Obesity with Insulin Resistance
    Rosario Scalia; Fiscal Year: 2009
    ..states of obesity-associated insulin resistance, elevated AngII signaling synergizes with neutrophil-derived myeloperoxidase (MPO) to cause vascular dysfunction via activation of calpain in the vascular endothelium...
  93. In Vivo Mechanisms of Vascular Dysfunction in Obesity with Insulin Resistance
    ROSARIO G SCALIA; Fiscal Year: 2010
    ..states of obesity-associated insulin resistance, elevated AngII signaling synergizes with neutrophil-derived myeloperoxidase (MPO) to cause vascular dysfunction via activation of calpain in the vascular endothelium...
  94. SURGICAL CONTROL OF POST-TRAUMATIC LUNG INJURY
    David Fullerton; Fiscal Year: 1993
    ..18-20 In this model endotoxin-induced pulmonary endovascular neutrophil accumulation is related to lung myeloperoxidase (MPO) content...
  95. In Vivo Mechanisms of Vascular Dysfunction in Obesity with Insulin Resistance
    ROSARIO G SCALIA; Fiscal Year: 2010
    ..states of obesity-associated insulin resistance, elevated AngII signaling synergizes with neutrophil-derived myeloperoxidase (MPO) to cause vascular dysfunction via activation of calpain in the vascular endothelium...
  96. Molecular Imaging to Determine the Risk of Rupture of Cerebral Aneurysms
    Alexei Bogdanov; Fiscal Year: 2009
    ..Recent epidemiological evidence suggests that the elevated presence of myeloperoxidase (MPO) in blood is an important risk factor for coronary disease and atherosclerotic plaque rupture...