myeloperoxidase

Summary

Gene Symbol: myeloperoxidase
Description: myeloperoxidase
Species: human

Top Publications

  1. ncbi [Disturbed neutrophil activation in pneumonia during medicinal immunosuppression]
    J Braun
    Medizinische Klinik II,
    Pneumologie 51:1037-42. 1997
  2. ncbi Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic antibodies
    R Kettritz
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    J Am Soc Nephrol 12:37-46. 2001
  3. ncbi Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritis
    Hermann Josef Grone
    Department of Cellular and Molecular Pathology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Lab Invest 82:5-14. 2002
  4. ncbi Myeloperoxidase G-463A polymorphism and Alzheimer's disease in the ApoEurope study
    Brigitte Leininger-Muller
    INSERM Unite 525, Centre de Médecine Préventive and Faculté de Pharmacie, Nancy, France
    Neurosci Lett 349:95-8. 2003
  5. ncbi The effects of high-intensity exercise on skeletal muscle neutrophil myeloperoxidase in untrained and trained rats
    Vladimir I Morozov
    Department of Biochemistry, Research Institute of Physical Culture, Dynamo Ave 2, St Petersburg 197110, Russia
    Eur J Appl Physiol 97:716-22. 2006
  6. ncbi Oxidative stress-related genotypes, fruit and vegetable consumption and breast cancer risk
    Yulin Li
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Carcinogenesis 30:777-84. 2009
  7. ncbi Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis
    Sander S Rensen
    Department of Surgery, Maastricht University Medical Centre, PO Box 616, Maastricht 6200 MD, The Netherlands
    Am J Pathol 175:1473-82. 2009
  8. ncbi Myeloperoxidase enhances nitric oxide catabolism during myocardial ischemia and reperfusion
    Stephan Baldus
    Department of Cardiology, University Hospital Hamburg Eppendorf, 20246 Hamburg, Germany
    Free Radic Biol Med 37:902-11. 2004
  9. ncbi A myeloperoxidase polymorphism associated with reduced risk of lung cancer
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Box 189, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Lung Cancer 37:35-40. 2002
  10. ncbi Genetic variants of myeloperoxidase and catechol-O-methyltransferase and breast cancer risk
    S C Lin
    School of Public Health, National Defense Medical Center, No 161, Section 6 Min Chuan East Road, Taipei 114, Taiwan, Republic of China
    Eur J Cancer Prev 14:257-61. 2005

Research Grants

  1. Arsenic Trioxide and Acute Myeloid Leukemia
    Yongkui Jing; Fiscal Year: 2005
  2. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2010
  3. Mechanisms and Prevention of Etoposide-Induced Leukemia
    Jack Yalowich; Fiscal Year: 2009
  4. CFTR Expression and Function in Human Neutrophils
    Guoshun Wang; Fiscal Year: 2009
  5. CFTR Expression and Function in Human Neutrophils
    Guoshun Wang; Fiscal Year: 2010
  6. CFTR Expression and Function in Human Neutrophils
    Guoshun Wang; Fiscal Year: 2007
  7. EPIDEMIOLOGY OF INFANT LEUKEMIA
    Julie Ross; Fiscal Year: 2007
  8. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    KIRKWOOD A contact PRITCHARD; Fiscal Year: 2010
  9. Molecular Imaging Probes for Reporting on Vascular Oxidative Response
    Alexei A Bogdanov; Fiscal Year: 2010
  10. Regulation of Myeloperoxidase Catalysis by Nitric Oxide
    HUSAM ABU SOUD; Fiscal Year: 2004

Detail Information

Publications211 found, 100 shown here

  1. ncbi [Disturbed neutrophil activation in pneumonia during medicinal immunosuppression]
    J Braun
    Medizinische Klinik II,
    Pneumologie 51:1037-42. 1997
    ..In addition to the cell differential the BALF concentrations of the neutrophil degranulation products myeloperoxidase (MPO) and lactoferrin were determined using immunoluminometric assays...
  2. ncbi Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic antibodies
    R Kettritz
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    J Am Soc Nephrol 12:37-46. 2001
    ..TNF-alpha-primed neutrophils were stimulated with monoclonal antibodies (MAb) to human myeloperoxidase (MPO) and proteinase 3 (PR3), and with preparations of human ANCA (three patients with PR3-ANCA and two ..
  3. ncbi Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritis
    Hermann Josef Grone
    Department of Cellular and Molecular Pathology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Lab Invest 82:5-14. 2002
    ..the nature of the in vivo oxidants has not been clearly identified, increasing evidence suggested the myeloperoxidase (MPO)-H(2)O(2)-halide system to be responsible for the damage observed in leukocyte-dependent ..
  4. ncbi Myeloperoxidase G-463A polymorphism and Alzheimer's disease in the ApoEurope study
    Brigitte Leininger-Muller
    INSERM Unite 525, Centre de Médecine Préventive and Faculté de Pharmacie, Nancy, France
    Neurosci Lett 349:95-8. 2003
    ..A polymorphism in the myeloperoxidase gene (MPO) has previously been associated with AD susceptibility...
  5. ncbi The effects of high-intensity exercise on skeletal muscle neutrophil myeloperoxidase in untrained and trained rats
    Vladimir I Morozov
    Department of Biochemistry, Research Institute of Physical Culture, Dynamo Ave 2, St Petersburg 197110, Russia
    Eur J Appl Physiol 97:716-22. 2006
    ..Neutrophil enzyme myeloperoxidase (MPO) was determined as a measure of neutrophil migration into muscles and blood neutrophil degranulation...
  6. ncbi Oxidative stress-related genotypes, fruit and vegetable consumption and breast cancer risk
    Yulin Li
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Carcinogenesis 30:777-84. 2009
    ..Genetic variations in catalase (CAT) (C-262T), myeloperoxidase (MPO) (G-463A), endothelial nitric oxide synthase (NOS3) (G894T) and heme oxygenase-1 (HO-1) [(GT)(n) ..
  7. ncbi Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis
    Sander S Rensen
    Department of Surgery, Maastricht University Medical Centre, PO Box 616, Maastricht 6200 MD, The Netherlands
    Am J Pathol 175:1473-82. 2009
    ..b>Myeloperoxidase (MPO) is an important neutrophil enzyme that can generate aggressive oxidants; therefore, we studied the ..
  8. ncbi Myeloperoxidase enhances nitric oxide catabolism during myocardial ischemia and reperfusion
    Stephan Baldus
    Department of Cardiology, University Hospital Hamburg Eppendorf, 20246 Hamburg, Germany
    Free Radic Biol Med 37:902-11. 2004
    ..Whereas myeloperoxidase (MPO), a highly abundant, PMN-derived heme protein facilitates oxidative NO consumption and impairs vascular ..
  9. ncbi A myeloperoxidase polymorphism associated with reduced risk of lung cancer
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Box 189, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Lung Cancer 37:35-40. 2002
    b>Myeloperoxidase (MPO) is a metabolic/oxidative enzyme found in neutrophils and monocytes that contributes to pulmonary carcinogenesis through activation of specific procarcinogens including benzo[a]pyrene intermediates, 4-aminobiphenyl ..
  10. ncbi Genetic variants of myeloperoxidase and catechol-O-methyltransferase and breast cancer risk
    S C Lin
    School of Public Health, National Defense Medical Center, No 161, Section 6 Min Chuan East Road, Taipei 114, Taiwan, Republic of China
    Eur J Cancer Prev 14:257-61. 2005
    This nested case-control study evaluated the role of polymorphisms in the myeloperoxidase (MPO) and catechol-O-methyltransferase (COMT) genes that modulate oxidative stress in breast cancer risk in a Chinese population...
  11. ncbi The MPO -463G>A polymorphism and cancer risk: a meta-analysis based on 43 case-control studies
    Haiyan Chu
    Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
    Mutagenesis 25:389-95. 2010
    b>Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species and plays an important role in the aetiology of cancer...
  12. ncbi A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk
    Chunyan He
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Breast Cancer Res Treat 113:585-94. 2009
    Oxidative stress may be involved in breast carcinogenesis. Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species (ROS)...
  13. ncbi Enzyme levels and G-463A polymorphism of myeloperoxidase in chronic lymphocytic leukemia and multiple myeloma
    Eyup Ilker Saygili
    Vocational School of Higher Education for Health Services, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey
    Leuk Lymphoma 50:2030-7. 2009
    The aim of this study was to investigate how myeloperoxidase (MPO) G-463A gene polymorphism and enzyme levels varied among patients with chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) and to find the relationship between ..
  14. ncbi Myeloperoxidase genotypes and enhanced efficacy of chemotherapy for early-stage breast cancer in SWOG-8897
    Christine B Ambrosone
    Roswell Park Cancer Institute, Department of Cancer Prevention and Control, Buffalo, NY 14263, USA
    J Clin Oncol 27:4973-9. 2009
    b>Myeloperoxidase (MPO) generates reactive oxygen species and also activates xenobiotics...
  15. ncbi Variation in the promoter region of the myeloperoxidase gene is not directly related to lung cancer risk among male smokers in Finland
    R R Misra
    Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, 6006 Executive Boulevard, Suite 321, Bethesda, MD 20892 7058, USA
    Cancer Lett 164:161-7. 2001
    In order to examine whether a polymorphism in the promoter region of the myeloperoxidase (MPO) gene is associated with lung cancer among male smokers, we conducted a case-control study nested within a Finnish clinical trial cohort...
  16. ncbi Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer risk
    Jiyoung Ahn
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Cancer Res 64:7634-9. 2004
    b>Myeloperoxidase (MPO), an antimicrobial enzyme in the breast, generates reactive oxygen species (ROS) endogenously...
  17. ncbi Relationships between polymorphisms in NOS3 and MPO genes, cigarette smoking and risk of post-menopausal breast cancer
    Jun Yang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 28:1247-53. 2007
    NOS3 and MPO genes encode endothelial nitric oxide synthase and myeloperoxidase (MPO), respectively, which generate nitric oxide and reactive oxygen species...
  18. ncbi Glycosylation pattern of mature dimeric leukocyte and recombinant monomeric myeloperoxidase: glycosylation is required for optimal enzymatic activity
    Pierre Van Antwerpen
    Laboratory of Pharmaceutical Chemistry and the Analytical Platform of Institute of Pharmacy, UniversitéLibre de Bruxelles, Brussels, Belgium
    J Biol Chem 285:16351-9. 2010
    The involvement of myeloperoxidase (MPO) in various inflammatory conditions has been the scope of many recent studies...
  19. ncbi Elevated levels of myeloperoxidase, white blood cell count and 3-chlorotyrosine in Taiwanese patients with acute myocardial infarction
    Mei Ling Cheng
    Graduate Institute of Medical Biotechnology and Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    Clin Biochem 41:554-60. 2008
    ..risk factor for acute myocardial infarction (AMI), is associated with leukocytic activation, secretion of myeloperoxidase (MPO) and generation of the oxidative damage marker, 3-chlorotyrosine (3-Cl-Tyr)...
  20. ncbi Myeloperoxidase-dependent caspase-3 activation and apoptosis in HL-60 cells: protection by the antioxidants ascorbate and (dihydro)lipoic acid
    Melinda C Myzak
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 6512, USA
    Redox Rep 7:47-53. 2002
    The heme enzyme myeloperoxidase (MPO) has recently been implicated in hydrogen peroxide H(2)O(2)-induced apoptosis of HL-60 human leukemia cells...
  21. ncbi X-ray crystal structure of canine myeloperoxidase at 3 A resolution
    J Zeng
    Department of Biochemistry and Molecular Biology, University of Miami Medical School, FL 33101
    J Mol Biol 226:185-207. 1992
    The three-dimensional structure of the enzyme myeloperoxidase has been determined by X-ray crystallography to 3 A resolution...
  22. ncbi Unique autolytic cleavage of human myeloperoxidase. Implications for the involvement of active site MET409
    K L Taylor
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 3050
    J Biol Chem 267:25282-8. 1992
    b>Myeloperoxidase (MPO) is a functionally important component of the normal human neutrophil host defense system...
  23. ncbi Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis
    Pierre Nahon
    Service d Hepatologie, Hopital Jean Verdier, AP HP, Bondy, France
    Hepatology 50:1484-93. 2009
    ..formation in hepatocyte mitochondria and by reduced nicotinamide adenine dinucleotide phosphate oxidases and myeloperoxidase (MPO) in Kupffer cells and liver-infiltrating neutrophils...
  24. ncbi Association of the polymorphisms of MTHFR C677T, VDR C352T, and MPO G463A with risk for esophageal squamous cell dysplasia and carcinoma
    Daqing Li
    Qilu Hospital, Shandong University, Jinan, China
    Arch Med Res 39:594-600. 2008
    ..samples to evaluate the association of polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T, vitamin D receptor (VDR) C352T, and myeloperoxidase (MPO) G463A genotypes with esophageal squamous cell dysplasia and carcinoma.
  25. ncbi Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the -463GA promoter polymorphism
    Alan P Kumar
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    J Biol Chem 279:8300-15. 2004
    A functional myeloperoxidase (MPO) promoter polymorphism, -463GA, has been associated with incidence or severity of inflammatory diseases, including atherosclerosis and Alzheimer's disease, and some cancers...
  26. ncbi Association between Alzheimer's disease and a functional polymorphism in the Myeloperoxidase gene
    F C Crawford
    Roskamp Institute and the University of South Florida Memory Disorder Clinic, 3515 East Fletcher Avenue, Tampa, Florida 33613, USA
    Exp Neurol 167:456-9. 2001
    A polymorphism in the Myeloperoxidase gene (MPO) has previously been demonstrated to be associated with gender-specific risk in an Alzheimer's Disease (AD) autopsy sample...
  27. ncbi MPO and APOEepsilon4 polymorphisms interact to increase risk for AD in Finnish males
    W F Reynolds
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Neurology 55:1284-90. 2000
    b>Myeloperoxidase (MPO) is present in senile plaques and surrounding reactive microglia, but not in normal brain parenchyma. MPO in plaques is highest in APOE epsilon4 carriers, suggesting a functional interaction...
  28. ncbi Gender and smoking-related risk reduction of periodontal disease with variant myeloperoxidase alleles
    P Meisel
    Department of Pharmacology, Ernst Moritz Arndt University Greifswald, Germany
    Genes Immun 3:102-6. 2002
    b>Myeloperoxidase (MPO) is an oxidative enzyme expressed in polymorphonuclear leukocytes. It is involved in the defence against periodontal bacteria, and is also able to mediate inflammatory tissue destruction in periodontal disease...
  29. ncbi Increased risk for Alzheimer disease with the interaction of MPO and A2M polymorphisms
    Mario Zappia
    Institute of Neurology, University Magna Graecia, Catanzaro, Italy
    Arch Neurol 61:341-4. 2004
    The genes encoding myeloperoxidase (MPO) and alpha(2)-macroglobulin (A2M) are involved in molecular pathways leading to beta-amyloid deposition...
  30. ncbi Myeloperoxidase (MPO) -463G->A reduces MPO activity and DNA adduct levels in bronchoalveolar lavages of smokers
    Frederik J Van Schooten
    Department of Health Risk Analysis and Toxicology, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 13:828-33. 2004
    The myeloperoxidase (MPO) -463G-->A genetic polymorphism is associated with a reduced risk for lung cancer, but the underlying mechanism is not yet elucidated...
  31. ncbi Genetic variants in SOD2, MPO, and NQO1, and risk of ovarian cancer
    S H Olson
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Gynecol Oncol 93:615-20. 2004
    ..Since the genes superoxide dismutase (SOD2), myeloperoxidase (MPO), and NAD(P)H:quinone oxidoreductase 1 (NQO1) are involved in inflammation and oxidative stress, we ..
  32. ncbi A genotypic association implicates myeloperoxidase in the progression of hepatic fibrosis in chronic hepatitis C virus infection
    W F Reynolds
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Genes Immun 3:345-9. 2002
    ..cells heavily represented in the inflammatory cell response, contain the oxidant generating enzyme myeloperoxidase (MPO)...
  33. ncbi Association between asbestos exposure, cigarette smoking, myeloperoxidase (MPO) genotypes, and lung cancer risk
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Holcombe Blvd, Houston, Texas 77303, USA
    Am J Ind Med 42:29-37. 2002
    As observed in tobacco-associated carcinogenesis, genetic factors such as the polymorphic metabolic/oxidative enzyme myeloperoxidase (MPO) could modulate individual susceptibility to asbestos-associated carcinogenesis.
  34. ncbi Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes
    Stephan Baldus
    University of Hamburg, Department of Cardiology, Martinistrasse 52, 20246 Hamburg, Germany
    Circulation 108:1440-5. 2003
    ..b>Myeloperoxidase (MPO), a hemoprotein abundantly expressed by PMNs and secreted during activation, possesses potent ..
  35. ncbi Counterpoint: the myeloperoxidase -463G-->a polymorphism does not decrease lung cancer susceptibility in Caucasians
    Li Lian Xu
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1555-9. 2002
    The myeloperoxidase (MPO) G-to-A substitution polymorphism in the promoter region of the MPO gene has been associated with a 40-70% reduction in lung cancer risk in several studies, although a recent nested case-control study disputes ..
  36. ncbi Myeloperoxidase (MPO) genotype and lung cancer histologic types: the MPO -463 A allele is associated with reduced risk for small cell lung cancer in smokers
    Heike Dally
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 102:530-5. 2002
    ..We confirm that the MPO -463 A variant affords a protective effect against lung cancer risk in smokers, which was strongest for SCLC patients...
  37. ncbi Point: myeloperoxidase -463G --> a polymorphism and lung cancer risk
    Anne Feyler
    Unit of Cancer Epidemiology INSERM U521, Gustave Roussy Institute, 94805 Villejuif, France
    Cancer Epidemiol Biomarkers Prev 11:1550-4. 2002
    b>Myeloperoxidase (MPO) is released from neutrophils in lung tissue in response to exposure to various pulmonary insults, including tobacco smoking...
  38. ncbi Genetic polymorphisms of MPO, COMT, MnSOD, NQO1, interactions with environmental exposures and bladder cancer risk
    Rayjean J Hung
    International Agency of Research on Cancer, Lyon 69008, France
    Carcinogenesis 25:973-8. 2004
    ..Several enzymes, which play key roles in oxidative stress are polymorphic in humans. Myeloperoxidase (MPO) produces a strong oxidant for microbicidal activity, and activates carcinogens in tobacco smoke...
  39. ncbi Myeloperoxidase polymorphism related to cardiovascular events in coronary artery disease
    Folkert W Asselbergs
    Am J Med 116:429-30. 2004
  40. ncbi A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers
    Shanbeh Zienolddiny
    Section of Toxicology, Department of Biological and Chemical Work Environment, National Institute of Occupational Health N 0033, Oslo, Norway
    Carcinogenesis 29:1164-9. 2008
    ..However, only four of the previously reported associations with polymorphisms in the GSTP1 (Ala14Val), SOD2 (Val16Ala), EPHX1 (His139Arg) genes and the NAT1 fast acetylator phenotype remained significantly associated with lung cancer...
  41. ncbi Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer
    Christine B Ambrosone
    Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Res 65:1105-11. 2005
    ..dismutase catalyzes conversion of superoxide radicals to H(2)O(2), with catalase neutralizing H(2)O(2) and myeloperoxidase converting H(2)O(2) to highly reactive hypochlorous acid, we hypothesized that gene variants could impact the ..
  42. ncbi Killing activity of neutrophils is mediated through activation of proteases by K+ flux
    Emer P Reeves
    Centre for Molecular Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
    Nature 416:291-7. 2002
    ..by subjecting them to high concentrations of highly toxic reactive oxygen species (ROS) and bringing about myeloperoxidase-catalysed halogenation...
  43. ncbi Association of apolipoprotein E and myeloperoxidase genotypes to clinical course of familial and sporadic multiple sclerosis
    B Zakrzewska-Pniewska
    Department of Neurology, The Medical University of Warsaw, 02 097 Warsaw, Banacha 1a, Str, Poland
    Mult Scler 10:266-71. 2004
    The importance of apolipoprotein E (ApoE) and myeloperoxidase (MPO) genotypes in the clinical characteristics of multiple sclerosis (MS) has been recently emphasized...
  44. ncbi Interrogation of heme pocket environment of mammalian peroxidases with diatomic ligands
    H M Abu-Soud
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Biochemistry 40:10747-55. 2001
    Recent studies demonstrate that myeloperoxidase (MPO), eosinophil peroxidase (EPO), and lactoperoxidase (LPO), homologous members of the mammalian peroxidase superfamily, can all serve as catalysts for generating nitric oxide- (nitrogen ..
  45. ncbi Subcellular distribution of urokinase and urokinase receptor in human neutrophils determined by immunoelectron microscopy
    T L Pedersen
    Department of Pathology, Herlev Hospital, University of Copenhagen, Denmark
    Ultrastruct Pathol 24:175-82. 2000
    ..matrix metalloproteinase type-9 (MMP-9) for gelatinase granules, lactoferrin (LF) for specific granules, and myeloperoxidase (MPO) and neutrophil elastase (NE) for primary granules...
  46. ncbi Biochemical and physiological alterations in canine neutrophils separated by lysis or Percoll gradient isolation technologies
    D F Gruber
    Experimental Hematology Department, Armed Forces Radiobiology, Research Institute, Bethesda, Maryland 20814-5145
    Immunopharmacol Immunotoxicol 12:93-104. 1990
    ..Cellular isolation methods did not significantly alter cellular myeloperoxidase (MPO) levels based on comparisons of cellular totals...
  47. ncbi Improved survival and reversal of endothelial dysfunction by the 21-aminosteroid, U-74389G in splanchnic ischaemia-reperfusion injury in the rat
    F Squadrito
    Institute of Pharmacology, School of Medicine, University of Messina, Italy
    Br J Pharmacol 115:395-400. 1995
    ..TNF-alpha), white blood cell (WBC) count, mean arterial blood pressure (MAP), plasma malonyladehyde (MAL); myeloperoxidase activity (MPO) and the responsiveness to acetylcholine (ACh 10 nM-10 microM) of aortic rings were ..
  48. ncbi Ameliorative effects of sodium ferulate on experimental colitis and their mechanisms in rats
    Wei Guo Dong
    Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, Hubei Province, China
    World J Gastroenterol 9:2533-8. 2003
    ..To investigate the ameliorative effects of sodium ferulate (SF) on acetic acid-induced colitis and their mechanisms in rats...
  49. ncbi Andalusol, a diterpenoid with anti-inflammatory activity from Siderits foetens Clemen
    A Navarro
    , Facultad de Farmacia, Universidad Complutense de Madrid, Spain
    Z Naturforsch C 52:844-9. 1997
    ..Quantitation of the neutrophil specific marker, myeloperoxidase (MPO), demonstrated that its topical anti-inflammatory effect was associated with reduction in neutrophil ..
  50. ncbi [Myeloperoxidase, lactoferrin and elastase in bronchoalveolar lavage and plasma in pneumonia]
    J Braun
    ,
    Pneumologie 46:141-7. 1992
    ..bronchoalveolar lavage (BALF) and in plasma, the concentration of the locally produced granulocyte products myeloperoxidase (MPO), lactoferrin (LF) and elastase-alpha 1 proteinase complex (ELA) as well as of the alpha 1 proteinase ..
  51. ncbi Myelopoietin, a chimeric agonist of human interleukin 3 and granulocyte colony-stimulating factor receptors, mobilizes CD34+ cells that rapidly engraft lethally x-irradiated nonhuman primates
    T J MacVittie
    Greenebaum Cancer Center, Baltimore, MD 21201, USA
    Exp Hematol 27:1557-68. 1999
    ....
  52. ncbi Study of the topical anti-inflammatory activity of Achillea ageratum on chronic and acute inflammation models
    M A Gomez
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Sevilla, Spain
    Z Naturforsch C 54:937-41. 1999
    ....
  53. ncbi 15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury
    Driss El Kebir
    Research Center, Maisonneuve Rosemont Hospital, Montreal, Quebec
    Am J Respir Crit Care Med 180:311-9. 2009
    ..b>Myeloperoxidase (MPO), abundantly expressed in neutrophils, not only generates cytotoxic oxidants but also signals through ..
  54. ncbi Nitrite enhances neutrophil-induced DNA strand breakage in pulmonary epithelial cells by inhibition of myeloperoxidase
    Ad M Knaapen
    Department of Health Risk Analysis and Toxicology, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Carcinogenesis 26:1642-8. 2005
    ..that nitrite may affect the toxicity of neutrophils, involving an interaction with neutrophil-derived myeloperoxidase (MPO)...
  55. ncbi Contribution of intercellular adhesion molecule 1 (ICAM-1) to the pathogenesis of splanchnic artery occlusion shock in the rat
    F Squadrito
    Institute of Pharmacology, School of Medicine, University of Messina, Italy
    Br J Pharmacol 113:912-6. 1994
    ..serum tumour necrosis factor-alpha (TNF-alpha), white blood cell (WBC) count, mean arterial blood pressure, myeloperoxidase activity (MPO; studied as a quantitative means to assess leukocyte accumulation) and the responsiveness to ..
  56. ncbi Pancreatic phospholipase A2 induces bacterial translocation in rats
    H Hongo
    First Department of Medicine, Kyoto Prefectural University of Medicine, Japan
    Immunopharmacol Immunotoxicol 21:717-26. 1999
    ....
  57. ncbi [A case of fluminant septic shock due to Streptococcus agalactiae in a patient with MPO-ANCA related glomerulonephritis]
    A Tanaka
    Department of Nephrology, Saiseikai Nakatsu Hospital, Osaka, Japan
    Kansenshogaku Zasshi 70:1186-9. 1996
    ..S. agalactiae was isolated from the blood. Autopsy revealed bilateral bronchopneumonia and shock liver. To our knowledge, this is the first report of septic shock caused by S. agalactiae...
  58. ncbi Circular permutation of the granulocyte colony-stimulating factor receptor agonist domain of myelopoietin
    C A McWherter
    Searle Discovery Research, Monsanto Company, St Louis, Missouri 63198, USA
    Biochemistry 38:4564-71. 1999
    ..It was found that circular permutation of the G-CSF domain can alter the ratio of G-CSFR:IL-3R agonist activities, demonstrating that it is a useful tool in engineering chimeric proteins with therapeutic potential...
  59. ncbi Investigation of mechanism(s) of DNA damage induced by 4-monochlorobiphenyl (PCB3) metabolites
    Wei Xie
    Department of Occupational and Environmental Health, University of Iowa, College of Public Health, Iowa City, Iowa 52242, USA
    Environ Int 36:950-61. 2010
    ..To examine this hypothesis, we employed two cell lines with different myeloperoxidase (MPO) activities, MPO-rich HL-60 and MPO-deficient Jurkat cells, and measured cytotoxicity, DNA damage (COMET ..
  60. ncbi [Study on pathogenetic role of myeloperoxidase, tumor necrosis factor alpha, interferon gamma in chronic airway infection with Pseudomonas aeruginosa]
    H Takeda
    First Department of Internal Medicine, Kyorin University, School of Medicine
    Kansenshogaku Zasshi 72:395-409. 1998
    ..aeruginosa...
  61. ncbi [Effects of N-acetylcysteine on mRNA expression of monocyte chemotactic protein and macrophage inflammatory protein 2 in acute necrotizing pancreatitis: experiment with rats]
    Chun Fang Xu
    Department of Gastroenterology, First Affiliated Hospital of Soochow University, Suzhou 215006, China
    Zhonghua Yi Xue Za Zhi 88:711-5. 2008
    ....
  62. ncbi Healing process induced by a flavonic fraction of Bidens aurea on chronic gastric lesion in rat. Role of angiogenesis and neutrophil inhibition
    M Martin Calero
    Laboratorio de Farmacologia, Facultad de Farmacia, Universidad de Sevilla, Espana
    Z Naturforsch C 51:570-7. 1996
    ..b>Myeloperoxidase (MPO) activity was assayed and used as an index of leucocyte infiltration...
  63. ncbi Endocytosis of microperoxidase in the marginal cells of stria vascularis
    Akinobu Kakigi
    Department of Otolaryngology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Auris Nasus Larynx 34:39-43. 2007
    ..We investigated the basic properties of endocytosis in the marginal cells of stria vascularis (SV) to discuss whether marginal cells have a potential to maintain the endolymph homeostasis...
  64. ncbi Analysis of MPO-ANCA subtypes in a patient with propylthiouracil-induced vasculitis with multiple complications
    K Ohta
    Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan
    Clin Nephrol 68:315-21. 2007
    ..We report a 16 year-old girl with propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-positive glomerulonephritis combined with Henoch-Schönlein purpura nephritis (HSPN) and antiphospholipid syndrome (APS)...
  65. ncbi Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation
    Y Bilsel
    Department of General Surgery, Istanbul Medical Faculty, Istanbul, Turkey
    Dig Surg 19:306-11; discussion 311-2. 2002
    ..Another aspect of the study was to find out whether these substances have any effect on nitric oxide (NO) and free radical production...
  66. ncbi Protection of Veratrum nigrum L. var. ussuriense Nakai alkaloids against ischemia-reperfusion injury of the rat liver
    Zhen Zhen Wang
    Department of Pharmacology, Dalian Medical University, Dalian 116027, Liaoning Province, China
    World J Gastroenterol 13:564-71. 2007
    ..To investigate the protective effects and possible mechanisms of Veratrum nigrum L.var. ussuriense Nakai alkaloids (VnA) on hepatic ischemia/reperfusion (I/R) injury in rats...
  67. ncbi The effects of chronic exposure to ethanol and cigarette smoke on the formation of peroxynitrite, level of nitric oxide, xanthine oxidase and myeloperoxidase activities in rat kidney
    Yilmaz Cigremis
    Department of Biology, Faculty of Art and Science, Kafkas University, 36100, Kars, Turkey
    Mol Cell Biochem 291:127-38. 2006
    ..The animals were killed and the kidneys were removed to determine the activity of xanthine oxidase (XO), myeloperoxidase (MPO) and the levels of nitric oxide (NO)...
  68. ncbi Plasma myeloperoxidase, NT-proBNP, and troponin-I in patients on CAPD compared with those on regular hemodialysis
    Abdulla Al-Hweish
    Department of Internal Medicine, King Fahd University Hospital, Al Khobar, Saudi Arabia
    Hemodial Int 14:308-15. 2010
    b>Myeloperoxidase (MPO) is a hemoprotein that is released during inflammation and may lead to irreversible protein and lipid modification, increasing levels of oxidized low density lipoprotein, and promoting athrogenesis...
  69. ncbi Analytical and diagnostic accuracy of the EliA automated enzyme fluoroimmunoassay for antineutrophil cytoplasmic autoantibody detection
    Danilo Villalta
    Immunologia Clinica e Virologia, Azienda Ospedaliera Santa Maria degli Angeli, Via Montereale 24, 33170 Pordenone, Italy
    Clin Chem Lab Med 42:1161-7. 2004
    Anti-proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCA) and anti-myeloperoxidase antibodies (MPO-ANCA) are considered important serological markers for several forms of idiopathic systemic vasculitis...
  70. ncbi Clinical significance of a myeloperoxidase gene polymorphism and inducible nitric oxide synthase expression in cirrhotic patients with hepatopulmonary syndrome
    Yanying Wang
    Department of Gastroenterology, Heilongjiang Provincial Hospital, Harbin, 150036, China
    J Huazhong Univ Sci Technolog Med Sci 30:437-42. 2010
    The clinical significance of a myeloperoxidase (MPO) gene polymorphism and inducible nitric oxide synthase (iNOS) expression in cirrhotic patients with hepatopulmonary syndrome (HPS) was explored...
  71. ncbi Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis
    Arno G Siraki
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Dr, Research Triangle Park, NC 27709, USA
    Chem Res Toxicol 21:1143-53. 2008
    ..Here, we have investigated the metabolism of PA by myeloperoxidase (MPO) and the formation of an MPO protein free radical...
  72. ncbi Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis
    Arno G Siraki
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 20:1038-45. 2007
    ..We have investigated the metabolism of AG by myeloperoxidase (MPO) and the formation of an MPO protein free radical...
  73. ncbi Phosphatidylinositol 3-kinase controls antineutrophil cytoplasmic antibodies-induced respiratory burst in human neutrophils
    Ralph Kettritz
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Wiltbergstrasse 50, 13122 Berlin, Germany
    J Am Soc Nephrol 13:1740-9. 2002
    ..TNF-alpha-primed PMN were stimulated with a monoclonal antibody to myeloperoxidase (MPO) and with PR3- and MPO-ANCA, respectively. Akt activation was assessed with phospho-specific antibodies...
  74. ncbi Prolonged infections associated with antineutrophil cytoplasmic antibodies specific to proteinase 3 and myeloperoxidase: diagnostic and therapeutic challenge
    Branka Bonaci-Nikolic
    Institute of Allergy and Clinical Immunology, Clinical Center of Serbia, Belgrade, Serbia
    Clin Rheumatol 29:893-904. 2010
    ..markers may help in the diagnosis and the prognosis of infections associated with proteinase 3 (PR3) and myeloperoxidase (MPO)-ANCA. In this study (1993-2008)--with an average follow-up of 5...
  75. ncbi Pulmonary fibrosis in myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitides
    Sakae Homma
    Division of Respiratory Diseases, Toranomon Hospital and Okinaka Memorial Institute for Medical Research, Tokyo, Japan
    Respirology 9:190-6. 2004
    The association of pulmonary fibrosis (PF) with myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitides has not been well documented...
  76. ncbi [Role of intestinal lymphatic in myocardial injury in rats receiving hemorrhage and lipopolysaccharide challenge]
    Zi gang Zhao
    Department of Pathophysiology, Hebei Northern University, Zhangjiakou 075000, Hebei, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:97-100. 2010
    ..To explore the effect of mesenteric lymph duct ligation in protecting myocardial injury in rats after hemorrhage and lipopolysaccharide (LPS) challenge...
  77. ncbi NADPH oxidase but not myeloperoxidase protects lymphopenic mice from spontaneous infections
    Dmitry V Ostanin
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, P O Box 33932, Shreveport, LA 71130 3932, USA
    Biochem Biophys Res Commun 355:801-6. 2007
    ..The objective of this study was to ascertain what role phagocyte-associated NADPH oxidase or myeloperoxidase (MPO) plays in host defense in mice lacking both T- and B-cells...
  78. ncbi Clinical characteristics of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis caused by antithyroid drugs
    Jaeduk Yoshimura Noh
    Ito Hospital, Internal Medicine, 4 3 6 Jigumae, Shibuya ku, Tokyo, Japan
    J Clin Endocrinol Metab 94:2806-11. 2009
    The clinical characteristics of myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis caused by antithyroid drugs are still unclear because most reports describe only a small number of patients.
  79. ncbi Epitope analysis of myeloperoxidase-specific antineutrophil cytoplasmic autoantibodies (MPO-ANCA) in childhood onset Graves' disease treated with propylthiouracil
    M Fujieda
    Department of Pediatrics, Kochi University Medical School, Kochi, Japan
    Clin Nephrol 63:437-45. 2005
    ..aimed to elucidate the relationship between epitope profiles and clinical manifestations of patients with myeloperoxidase antineutrophil cytoplasmic autoantibodies-(MPO-ANCA) positive childhood onset Graves' disease treated with ..
  80. ncbi Effects of S-ethylisothiourea, a potent inhibitor of nitric oxide synthase, alone or in combination with a nitric oxide donor in splanchnic artery occlusion shock
    F Squadrito
    Institute of Pharmacology, School of Medicine, University of Messina, Italy
    Br J Pharmacol 119:23-8. 1996
    ..Survival time, white blood cell (WBC) count, mean arterial blood pressure, myeloperoxidase activity (MPO; studied as a quantitative means to evaluate neutrophil accumulation) and the responsiveness of ..
  81. ncbi Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation
    Renliang Zhang
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 277:46116-22. 2002
    ..b>Myeloperoxidase (MPO), a heme protein secreted by activated leukocytes, generates reactive intermediates that promote lipid ..
  82. ncbi Myeloperoxidase concentration in bronchoalveolar lavage fluid from healthy horses and those with recurrent airway obstruction
    Tatiana Art
    Equine Sports Medicine Centre, Faculty of Veterinary Medicine, University of Liege, Belgium
    Can J Vet Res 70:291-6. 2006
    The aim of this work was to measure the myeloperoxidase (MPO) concentration in bronchoalveolar lavage (BAL) fluid collected from horses with recurrent airway obstruction (RAO), both in crisis and in remission, as well as from healthy ..
  83. ncbi Analysis of T-cell receptor usage in myeloperoxidase--antineutrophil cytoplasmic antibody-associated renal vasculitis
    Kouichi Hirayama
    Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, 3 20 1 Chuo, Ami, Ibaraki, 300 0395, Japan
    Clin Exp Nephrol 14:36-42. 2010
    ..We investigated T-cell subsets to assess the superantigens present in patients with myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis.
  84. ncbi Quality of life evolution after surgery for primary or secondary spontaneous pneumothorax: a prospective study comparing different surgical techniques
    Bram Balduyck
    Department of Thoracic and Vascular Surgery, University Hospital of Antwerp, Wilrijkstraat 10, B 2650 Edegem, Belgium
    Interact Cardiovasc Thorac Surg 7:45-9. 2008
    ..037). After surgery, AT and VATS are comparable in QoL subscales with exception of a significant difference at 1 MPO in favour of VATS. Dyspnoea and coughing improved after surgery...
  85. ncbi PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells
    I Nuchprayoon
    Division of Pediatric Oncology, Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland 21287
    Mol Cell Biol 14:5558-68. 1994
    The myeloperoxidase (MPO) and neutrophil elastase genes are expressed specifically in immature myeloid cells...
  86. ncbi Neutrophil activation in morbid obesity, chronic activation of acute inflammation
    Jeroen Nijhuis
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of General Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
    Obesity (Silver Spring) 17:2014-8. 2009
    ..Neutrophil activation was assessed by measuring circulating concentrations of myeloperoxidase (MPO) and calprotectin in 37 severely obese and 9 control subjects (enzyme-linked immunosorbent assay)...
  87. ncbi Genetic dissection of vasculitis, myeloperoxidase-specific antineutrophil cytoplasmic autoantibody production, and related traits in spontaneous crescentic glomerulonephritis-forming/Kinjoh mice
    Yoshitomo Hamano
    Department of Pathology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Immunol 176:3662-73. 2006
    ..mouse is a model of human crescentic glomerulonephritis and vasculitis associated with the production of the myeloperoxidase (MPO)-specific antineutrophil cytoplasmic autoantibody (MPO-ANCA)...
  88. ncbi Analysis of risk epitopes of anti-neutrophil antibody MPO-ANCA in vasculitis in Japanese population
    Kazuo Suzuki
    Laboratory of Biodefense, Department of Bioactive Molecules, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    Microbiol Immunol 51:1215-20. 2007
    Autoantibodies to myeloperoxidase (MPO) are a subset of anti-neutrophil cytoplasmic antibody (ANCA, MPO-ANCA) detected in the sera of some patients with primary systemic vasculitis...
  89. ncbi Differential effects of myeloperoxidase-derived oxidants on Escherichia coli DNA replication
    H Rosen
    Departments of Medicine, University of Washington, Seattle, Washington 98195, USA
    Infect Immun 66:2655-9. 1998
    The microbicidal myeloperoxidase (MPO)-H2O2-chloride system strongly inhibits Escherichia coli DNA synthesis. Also, cell envelopes from MPO-treated E...
  90. ncbi Diagnostic performance of antineutrophil cytoplasmic antibody tests for idiopathic vasculitides: metaanalysis with a focus on antimyeloperoxidase antibodies
    H K Choi
    Department of Medicine, Massachusetts General Hospital, Boston 02114, USA
    J Rheumatol 28:1584-90. 2001
    ..To summarize the pertinent data, we conducted a metaanalysis examining the diagnostic value of ANCA testing systems that include assays for anti-MPO...
  91. ncbi Identification of acute myeloid leukemia in dogs using flow cytometry with myeloperoxidase, MAC387, and a canine neutrophil-specific antibody
    Elizabeth Villiers
    Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, UK
    Vet Clin Pathol 35:55-71. 2006
    ..Flow cytometry may be used to determine immunophenotype or lineage of leukemic cells, but few antibodies are available that are specific for cells of monocytic and granulocytic lineage...
  92. ncbi [Case of MPO-ANCA-associated vasculitis with membranous nephropathy]
    Sayaka Watanabe
    First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan
    Nihon Jinzo Gakkai Shi 53:46-52. 2011
    We experienced a rare case of membranous glomerulopathy(MN) with myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-associated glomerulonephritis...
  93. ncbi Propylthiouracil associated antineutrophil cytoplasmic antibodies (ANCA) in patients with childhood onset Graves' disease
    Ouyporn Panamonta
    Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    J Pediatr Endocrinol Metab 21:539-43. 2008
    Propylthiouracil (PTU) can induce anti-myeloperoxidase (MPO-ANCA) positive vasculitis...
  94. ncbi Flavonoids as substrates and inhibitors of myeloperoxidase: molecular actions of aglycone and metabolites
    Yuko Shiba
    Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima, Tokushima 770 8503, Japan
    Chem Res Toxicol 21:1600-9. 2008
    b>Myeloperoxidase (MPO), secreted by activated neutrophils and macrophages at the site of inflammation, may be implicated in the oxidation of protein/lipoprotein during the development of cardiovascular diseases...
  95. ncbi Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes
    Daniela B Munafo
    Department of Molecular and Experimental Medicine, Division of Biochemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 402:229-39. 2007
    ..Rab27a-deficient mice have impaired secretion of MPO (myeloperoxidase) into the plasma in response to lipopolysaccharide...
  96. ncbi An IgM class anti-neutrophil cytoplasm antibody inhibits neutrophil adhesion and apoptosis via a Syk dependent signaling cascade
    M J Hayes
    Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, UK
    Mol Immunol 41:457-68. 2004
    Anti-neutrophil cytoplasm antibodies (ANCA) with specificity for myeloperoxidase (MPO) are implicated as pathogenic agents in pauci-immune systemic vasculitis...
  97. ncbi Reactions of pholasin with peroxidases and hypochlorous acid
    S Reichl
    Institute of Medical Physics and Biophysics, School of Medicine, University of Leipzig, Leipzig, Germany
    Free Radic Biol Med 28:1555-63. 2000
    The ability of myeloperoxidase (MPO) and horseradish peroxidase (HRP) to induce chemiluminescence (CL) in Pholasin (Knight Scientific, Plymouth, UK), the photoprotein of the Common Piddock Pholas dactylus, was studied...
  98. ncbi Measurement of equine myeloperoxidase (MPO) activity in synovial fluid by a modified MPO assay and evaluation of joint diseases - an initial case study
    S Fietz
    Institute of Veterinary Biochemistry, Freie Universitat Berlin, Oertzenweg 19b, D 14163 Berlin, Germany
    Res Vet Sci 84:347-53. 2008
    The aim of this study was to develop a specific myeloperoxidase (MPO) activity assay in the synovial fluid of horses and investigate whether MPO activity is increased in different forms of joint diseases...
  99. ncbi The nitric oxide congener nitrite inhibits myeloperoxidase/H2O2/ Cl- -mediated modification of low density lipoprotein
    A C Carr
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    J Biol Chem 276:1822-8. 2001
    ..Recent studies have shown that myeloperoxidase (MPO), an abundant heme protein released by activated leukocytes, can oxidize nitrite (NO(2-)) to a radical ..
  100. ncbi Myeloperoxidase interacts with endothelial cell-surface cytokeratin 1 and modulates bradykinin production by the plasma Kallikrein-Kinin system
    Joshua M Astern
    Burnett Womack, UNC Kidney Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7155, USA
    Am J Pathol 171:349-60. 2007
    During an inflammatory state, functional myeloperoxidase (MPO) is released into the vessel as a result of intravascular neutrophil degradation...

Research Grants96

  1. Arsenic Trioxide and Acute Myeloid Leukemia
    Yongkui Jing; Fiscal Year: 2005
    ..amounts of glutathione-s-transferase pi (GSTpi), glutathione peroxidase (GPx), catalase and high amounts of myeloperoxidase (MPO); 2) APL cells were highly sensitive to As2O3-induced apoptosis in vitro by a hydrogen peroxide (H2O2) ..
  2. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2010
    ..While generally attributed to the phagocyte-specific enzyme myeloperoxidase (MPO), it is unclear whether a peroxidase other than MPO in vascular wall plays a role in atherogenesis...
  3. Mechanisms and Prevention of Etoposide-Induced Leukemia
    Jack Yalowich; Fiscal Year: 2009
    ..The central hypothesis is that redox cycling of the phenolic anticancer agent etoposide (VP-16) by myeloperoxidase (MPO) found in myeloid progenitors amplifies the genotoxicity and carcinogenicity of this DNA topoisomerase ..
  4. CFTR Expression and Function in Human Neutrophils
    Guoshun Wang; Fiscal Year: 2009
    ..main phagocytes responsible for elimination of pathogens and cell debris, synthesize and maintain abundant myeloperoxidase (MPO)...
  5. CFTR Expression and Function in Human Neutrophils
    Guoshun Wang; Fiscal Year: 2010
    ..main phagocytes responsible for elimination of pathogens and cell debris, synthesize and maintain abundant myeloperoxidase (MPO)...
  6. CFTR Expression and Function in Human Neutrophils
    Guoshun Wang; Fiscal Year: 2007
    ..main phagocytes responsible for elimination of pathogens and cell debris, synthesize and maintain abundant myeloperoxidase (MPO)...
  7. EPIDEMIOLOGY OF INFANT LEUKEMIA
    Julie Ross; Fiscal Year: 2007
    ..This study will utilize the unique resources available through the Children's Oncology Group, and include ascertainment of cases over a four-year period (Jan 1, 2003-Dec 31, 2006). ..
  8. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    KIRKWOOD A contact PRITCHARD; Fiscal Year: 2010
    ..of HDL and therefore HDL function and if targeting oxidative stress induced by 1) xanthine oxidase (XO);2) myeloperoxidase (MPO);3) cell free hemoglobin (Hb);and, 4) oxidized lipids prevents oxidation of HDL and other lipoproteins ..
  9. Molecular Imaging Probes for Reporting on Vascular Oxidative Response
    Alexei A Bogdanov; Fiscal Year: 2010
    ..b>Myeloperoxidase (MPO, one of the components released by PMNs via triggered exocytosis) is a unique catalytically active ..
  10. Regulation of Myeloperoxidase Catalysis by Nitric Oxide
    HUSAM ABU SOUD; Fiscal Year: 2004
    b>Myeloperoxidase (MPO) is abundant hemoprotein present in neutrophils and monocytes which plays an essential role in immune surveillance and host defense mechanisms...
  11. MYELOPEROXIDASE, OXIDANT STRESS AND ATHEROGENESIS
    Stanley Hazen; Fiscal Year: 2002
    ..This proposal focuses on oxidation reactions catalyzed by myeloperoxidase (MPO) and the potential utility of protein oxidation products of distinct oxidation pathways to serve as non-..
  12. MPO and NO signaling in neointima formation
    Chunxiang Zhang; Fiscal Year: 2007
    ..b>Myeloperoxidase (MPO) is a leukocyte-derived heme protein...
  13. MPO and NO signaling in neointima formation
    Chunxiang Zhang; Fiscal Year: 2010
    ..b>Myeloperoxidase (MPO) is a leukocyte-derived heme protein...
  14. LIPID PEROXIDATION IN COLORECTAL CANCER
    Manuela Gago Dominguez; Fiscal Year: 2009
    ..1. To conduct a family-based case-control association study of oxidative stress-related genes, including myeloperoxidase (MPO), endothelial cell nitric oxide synthase (ecNOS), manganese superoxide dismutase (MnSOD), selenium-..
  15. LIPID PEROXIDATION IN COLORECTAL CANCER
    Manuela Gago Dominguez; Fiscal Year: 2007
    ..1. To conduct a family-based case-control association study of oxidative stress-related genes, including myeloperoxidase (MPO), endothelial cell nitric oxide synthase (ecNOS), manganese superoxide dismutase (MnSOD), selenium-..
  16. Angiotensin II, oxidative stress and aneurysm formation
    Neal L Weintraub; Fiscal Year: 2010
    ..are capable of inducing vascular oxidant stress and potentially contributing to AAA, we hypothesis that myeloperoxidase (MPO) is instrumental in this process...
  17. A TRANSCRIPTIONAL PROGRAM REGULATING MYELOPOIESIS
    Alan Friedman; Fiscal Year: 2004
    ..Myelopoiesis at various levels of C/EBP activity and progenitor fate after various times of C/EBP inhibition will be assessed. ..
  18. Nitric Oxide-Mediated Oxidation/Nitration in Membranes
    Balaraman Kalyanaraman; Fiscal Year: 2010
    ..g., atherosclerosis, diabetes, Parkinson's and Lou Gehrig's). ..
  19. In Vivo Mechanisms of Vascular Dysfunction in Obesity with Insulin Resistance
    Rosario Scalia; Fiscal Year: 2009
    ..states of obesity-associated insulin resistance, elevated AngII signaling synergizes with neutrophil-derived myeloperoxidase (MPO) to cause vascular dysfunction via activation of calpain in the vascular endothelium...
  20. In Vivo Mechanisms of Vascular Dysfunction in Obesity with Insulin Resistance
    ROSARIO G SCALIA; Fiscal Year: 2010
    ..states of obesity-associated insulin resistance, elevated AngII signaling synergizes with neutrophil-derived myeloperoxidase (MPO) to cause vascular dysfunction via activation of calpain in the vascular endothelium...
  21. In Vivo Mechanisms of Vascular Dysfunction in Obesity with Insulin Resistance
    ROSARIO G SCALIA; Fiscal Year: 2010
    ..states of obesity-associated insulin resistance, elevated AngII signaling synergizes with neutrophil-derived myeloperoxidase (MPO) to cause vascular dysfunction via activation of calpain in the vascular endothelium...
  22. Role of Triggering Receptors Expressed on Myeloid Cells in Bacterial Keratitis
    Xi Huang; Fiscal Year: 2010
    ..plate counts, siRNA interference, LPS stimulation, cross-linking activation, histopathology, TransAM assay, myeloperoxidase (MPO) assay for PMN quantitation, peritoneal macrophage isolation, transient transfection, gene ..
  23. Myeloperoxidase, imaging biomarker and treatment target for multiple sclerosis
    John W Chen; Fiscal Year: 2010
    ..b>Myeloperoxidase (MPO) is a highly oxidizing enzyme abundantly secreted by active macrophages/microglial cells and certain ..