MYCBP2

Summary

Gene Symbol: MYCBP2
Description: MYC binding protein 2, E3 ubiquitin protein ligase
Alias: Myc-bp2, PAM, Phr, E3 ubiquitin-protein ligase MYCBP2, Highwire, RING-type E3 ubiquitin transferase MYCBP2, myc-binding protein 2, pam/highwire/rpm-1 protein, protein associated with Myc
Species: human
Products:     MYCBP2

Top Publications

  1. Saiga T, Fukuda T, Matsumoto M, Tada H, Okano H, Okano H, et al. Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development. Mol Cell Biol. 2009;29:3529-43 pubmed publisher
    ..Proteomics analysis revealed that Fbxo45 specifically associates with PAM (protein associated with Myc), a RING finger-type ubiquitin ligase...
  2. Weidenbach K, Nickel L, Neve H, Alkhnbashi O, Künzel S, Kupczok A, et al. Methanosarcina Spherical Virus, a Novel Archaeal Lytic Virus Targeting Methanosarcina Strains. J Virol. 2017;91: pubmed publisher
    ..i>Methanosarcina draft genomes using bioinformatic tools, revealing a potential protospacer-adjacent motif (PAM) motif (TTA/T)...
  3. Hagstrom D, Hirokawa H, Zhang L, Radic Z, Taylor P, Collins E. Planarian cholinesterase: in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation. Arch Toxicol. 2017;91:2837-2847 pubmed publisher
    ..Diazinon oxon-inhibited DjChE could be reactivated by the quaternary oxime, pralidoxime (2-PAM), and the zwitterionic oxime, RS194B, with RS194B being significantly more potent...
  4. Yoder J, Straif Bourgeois S, Roy S, Moore T, Visvesvara G, Ratard R, et al. Primary amebic meningoencephalitis deaths associated with sinus irrigation using contaminated tap water. Clin Infect Dis. 2012;55:e79-85 pubmed publisher
    ..Primary amebic meningoencephalitis (PAM), which is almost universally fatal, occurs when N...
  5. Zhang Y, Sun R, Geng S, Shan Y, Li X, Fang W. Porcine Circovirus Type 2 Induces ORF3-Independent Mitochondrial Apoptosis via PERK Activation and Elevation of Cytosolic Calcium. J Virol. 2019;93: pubmed publisher
    ..an ORF3-deficient PCV2 mutant (ΔORF3), apoptotic responses in infected PK-15 and porcine alveolar macrophage (PAM) cells were still apparent, although lower than in the parental PCV2 strain...
  6. Dunn A, Reed T, Stewart C, Levy R. Naegleria fowleri That Induces Primary Amoebic Meningoencephalitis: Rapid Diagnosis and Rare Case of Survival in a 12-Year-Old Caucasian Girl. Lab Med. 2016;47:149-54 pubmed publisher
    Primary amoebic meningoencephalitis (PAM) is a rare and almost always fatal disease that is caused by Naegleria fowleri, a freshwater thermophilic amoeba. Our case involves an adolescent female who presented with fever of unknown origin...
  7. Singh A, Perry D, Steffey V, Miller K, Allison D. Decoding the Epigenetic Heterogeneity of Human Pluripotent Stem Cells with Seamless Gene Editing. Methods Mol Biol. 2016;1516:153-169 pubmed publisher
    ..ssODN) as donors to create point mutations, as the use of ssODN necessitate additional mutations in the donor PAM sequence, along with extensive cloning efforts...
  8. Luxmi R, Blaby Haas C, Kumar D, Rauniyar N, King S, Mains R, et al. Proteases Shape the Chlamydomonas Secretome: Comparison to Classical Neuropeptide Processing Machinery. Proteomes. 2018;6: pubmed publisher
    The recent identification of catalytically active peptidylglycine α-amidating monooxygenase (PAM) in Chlamydomonas reinhardtii, a unicellular green alga, suggested the presence of a PAM-like gene and peptidergic signaling in the last ..
  9. Alzarea S, Rahman S. Alpha-7 nicotinic receptor allosteric modulator PNU120596 prevents lipopolysaccharide-induced anxiety, cognitive deficit and depression-like behaviors in mice. Behav Brain Res. 2019;366:19-28 pubmed publisher
    ..The present study determined the effects of PNU120596, α7 nAChR positive allosteric modulator (PAM), on lipopolysaccharide (LPS)-induced anxiety, cognitive deficit, and depression-like behaviors in mice...

More Information

Publications105 found, 100 shown here

  1. Li L, Tian Y, Yu J, Song X, Jia R, Cui Q, et al. iTRAQ-based quantitative proteomic analysis reveals multiple effects of Emodin to Haemophilus parasuis. J Proteomics. 2017;166:39-47 pubmed publisher
    ..Phagocytosis assay showed Emodin also could enhance phagocytic activity of porcine alveolar macrophages PAM to H. parasuis. These results indicated that Emodin also can attenuate virulence of H...
  2. Lam C, Jamerson M, Cabral G, Carlesso A, Marciano Cabral F. Expression of matrix metalloproteinases in Naegleria fowleri and their role in invasion of the central nervous system. Microbiology. 2017;163:1436-1444 pubmed publisher
    ..amoeba found in freshwater lakes and ponds and is the causative agent of primary amoebic meningoencephalitis (PAM), a rapidly fatal disease of the central nervous system (CNS)...
  3. Wilhelm C, Snider T, Babin M, Jett D, Platoff G, Yeung D. A comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides. Toxicol Appl Pharmacol. 2014;281:254-65 pubmed publisher
    ..S.) is the administration of atropine in combination with an oxime antidote (2-PAM Cl) to reactivate inhibited acetylcholinesterase (AChE). Depending on clinical symptoms, an anticonvulsant, e.g...
  4. Ivanov S, Harrison M. A set of fluorescent protein-based markers expressed from constitutive and arbuscular mycorrhiza-inducible promoters to label organelles, membranes and cytoskeletal elements in Medicago truncatula. Plant J. 2014;80:1151-63 pubmed publisher
    ..plastids, mitochondria, peroxisomes, autophagosomes, plasmodesmata, actin, microtubules, periarbuscular membrane (PAM) and periarbuscular apoplastic space (PAS) and expressed them from the constitutive AtUBQ10 promoter and the AM ..
  5. Mateos Diaz E, Sutto Ortiz P, Sahaka M, Rodriguez J, Carriere F. IR spectroscopy analysis of pancreatic lipase-related protein 2 interaction with phospholipids: 3. Monitoring DPPC lipolysis in mixed micelles. Chem Phys Lipids. 2018;211:77-85 pubmed publisher
    ..changes were correlated to variations in the concentrations of DPPC, lysophospholipids (lysoPC) and palmitic acid (Pam) using calibration curves established with these compounds individually mixed with NaTDC...
  6. Gomes T, Xie L, Brede D, Lind O, Solhaug K, Salbu B, et al. Sensitivity of the green algae Chlamydomonas reinhardtii to gamma radiation: Photosynthetic performance and ROS formation. Aquat Toxicol. 2017;183:1-10 pubmed publisher
    ..49-1677mGy/h) for 6h and chlorophyll fluorescence parameters obtained by PAM fluorometry, while two fluorescent probes carboxy-H2DFFDA and DHR 123 were used for the quantification ..
  7. Tuppeny M. Primary amoebic meningoencephalitis with subsequent organ procurement: a case study. J Neurosci Nurs. 2011;43:274-9 pubmed publisher
    Primary amoebic meningoencephalitis (PAM) is a rare and rapidly fatal disease caused by the Naegleria fowleri amoeba...
  8. Aubouy A, Olagnier D, Bertin G, Ezinmegnon S, Majorel C, Mimar S, et al. Nrf2-driven CD36 and HO-1 gene expression in circulating monocytes correlates with favourable clinical outcome in pregnancy-associated malaria. Malar J. 2015;14:358 pubmed publisher
    Pregnancy-associated malaria (PAM) constitutes one of the most severe forms of malaria infection leading to fetal growth restriction and high risk of infant death...
  9. Seong G, Sohn H, Kang H, Seo G, Kim J, Shin H. Production and characterization of monoclonal antibodies against cathepsin B and cathepsin B-Like proteins of Naegleria fowleri. Exp Parasitol. 2017;: pubmed publisher
    Naegleria fowleri causes fatal primary amoebic meningoencephalitis (PAM) in humans and experimental animals. In previous studies, cathepsin B (nfcpb) and cathepsin B-like (nfcpb-L) genes of N...
  10. Guerra Álvarez M, Moreno Ortega A, Navarro E, Fernández Morales J, Egea J, López M, et al. Positive allosteric modulation of alpha-7 nicotinic receptors promotes cell death by inducing Ca(2+) release from the endoplasmic reticulum. J Neurochem. 2015;133:309-19 pubmed publisher
    ..This study focuses on how the type II positive allosteric modulator (PAM II) PNU120596 affects intracellular Ca(2+) signaling and cell viability...
  11. Gould R, Nedelcovych M, Gong X, Tsai E, Bubser M, Bridges T, et al. State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 - Relation to antipsychotic-like drug effects. Neuropharmacology. 2016;102:244-53 pubmed publisher
    ..Recently, we reported that VU0467154, a selective positive allosteric modulator (PAM) of the M4 muscarinic acetylcholine receptor (mAChR), exhibits robust APD-like and cognitive enhancing activity in ..
  12. Chomba M, Mucheleng anga L, Fwoloshi S, Ngulube J, Mutengo M. A case report: primary amoebic meningoencephalitis in a young Zambian adult. BMC Infect Dis. 2017;17:532 pubmed publisher
    Primary amoebic meningoencephalitis (PAM) is a fulminant disease of the brain caused by Naegleria fowleri. Although the disease is rare, the case fatality rate is very high. In this report, we describe the first case of PAM in Zambia...
  13. Ibraheim R, Song C, Mir A, Amrani N, Xue W, Sontheimer E. All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo. Genome Biol. 2018;19:137 pubmed publisher
    ..NmeCas9 is compact, edits with high accuracy, and possesses a distinct protospacer adjacent motif (PAM), making it an excellent candidate for safe gene therapy applications...
  14. Valentini D, Ferrara G, Advani R, Hallander H, Maeurer M. Serum reactome induced by Bordetella pertussis infection and Pertussis vaccines: qualitative differences in serum antibody recognition patterns revealed by peptide microarray analysis. BMC Immunol. 2015;16:40 pubmed publisher
    ..goat anti-human IgG and analyzed using a GenePix 4000B microarray scanner, followed by statistical analysis, using PAM (Prediction Analysis for Microarrays) and the identification of uniquely recognized peptide epitopes. 367/3,085 (11...
  15. Nguyen V, Li Y, Qian W, Liu B, Tian C, Zhang W, et al. Contrast Agent Enhanced Multimodal Photoacoustic Microscopy and Optical Coherence Tomography for Imaging of Rabbit Choroidal and Retinal Vessels in vivo. Sci Rep. 2019;9:5945 pubmed publisher
    Multimodal imaging with photoacoustic microscopy (PAM) and optical coherence tomography (OCT) can be an effective method to evaluate the choroidal and retinal microvasculature...
  16. Zhang L, Wu M, Hu B, Chen H, Pan J, Ruan W, et al. Identification and molecular typing of Naegleria fowleri from a patient with primary amebic meningoencephalitis in China. Int J Infect Dis. 2018;72:28-33 pubmed publisher
    ..fulminant, and rapidly fatal central nervous system infection in humans called primary amebic meningoencephalitis (PAM). In 2016, a patient with suspected PAM was found in Zhejiang Province of China...
  17. Trubitsin B, Vershubskii A, Priklonskii V, Tikhonov A. Short-term regulation and alternative pathways of photosynthetic electron transport in Hibiscus rosa-sinensis leaves. J Photochem Photobiol B. 2015;152:400-15 pubmed publisher
    In this work, using the EPR and PAM-fluorometry methods, we have studied induction events of photosynthetic electron transport in Hibiscus rosa-sinensis leaves...
  18. Spradling K, Lumley L, Robison C, Meyerhoff J, Dillman J. Transcriptional analysis of rat piriform cortex following exposure to the organophosphonate anticholinesterase sarin and induction of seizures. J Neuroinflammation. 2011;8:83 pubmed publisher
    ..with 1 × LD50 sarin and subsequently treated with atropine sulfate, 2-pyridine aldoxime methylchloride (2-PAM), and the anticonvulsant diazepam. Control animals received an equivalent volume of vehicle and drug treatments...
  19. Lee Y, Lee C. Ivermectin inhibits porcine reproductive and respiratory syndrome virus in cultured porcine alveolar macrophages. Arch Virol. 2016;161:257-68 pubmed publisher
    ..Here, we sought to assess whether ivermectin suppresses PRRSV replication in cultured porcine alveolar macrophage (PAM) cells and to investigate the effect of ivermectin on the subcellular localization of the PRRSV N protein...
  20. Jamerson M, da Rocha Azevedo B, Cabral G, Marciano Cabral F. Pathogenic Naegleria fowleri and non-pathogenic Naegleria lovaniensis exhibit differential adhesion to, and invasion of, extracellular matrix proteins. Microbiology. 2012;158:791-803 pubmed publisher
    ..N. fowleri causes primary amoebic meningoencephalitis (PAM), a rapidly fatal disease of the central nervous system, while N. lovaniensis is non-pathogenic. N...
  21. Mohandas N, Young N, Jabbar A, Korhonen P, Koehler A, Hall R, et al. The complement of family M1 aminopeptidases of Haemonchus contortus--Biotechnological implications. Biotechnol Adv. 2016;34:65-76 pubmed publisher
    ..elegans T07F10.1; Hc-AP-9 and Hc-AP-10 to C. elegans PAM-1 (isoform b) (53-54% similar); Hc-AP-11 and Hc-AP-12 to C. elegans AC3.5 and Y67D8C...
  22. Srivastav A, Dhiman N, Tiwari R, Arjaria N, Prakash J, Jagdale P, et al. Sub-acute oral exposure of zinc oxide nanoparticles causes alteration in iron homeostasis through acute phase response: A protective effect by surface modification. J Trace Elem Med Biol. 2019;52:270-287 pubmed publisher
    ..toxicity, surface engineered ZnO NPs (c-ZnO NPs) were in-situ synthesized by using polyacrylamide grafted guar gum (PAm-g-GG) polymer in alkaline media...
  23. Moroncini G, Grieco A, Nacci G, Paolini C, Tonnini C, Pozniak K, et al. Epitope Specificity Determines Pathogenicity and Detectability of Anti-Platelet-Derived Growth Factor Receptor α Autoantibodies in Systemic Sclerosis. Arthritis Rheumatol. 2015;67:1891-903 pubmed publisher
    ..Epstein-Barr virus-immortalized B cells from 1 patient with SSc (designated PAM) were screened for expression of IgG binding to PDGFRα and induction of reactive oxygen species in fibroblasts...
  24. Chauvin J, Judée F, Yousfi M, Vicendo P, Merbahi N. Analysis of reactive oxygen and nitrogen species generated in three liquid media by low temperature helium plasma jet. Sci Rep. 2017;7:4562 pubmed publisher
    In order to identify aqueous species formed in Plasma activated media (PAM), quantitative investigations of reactive oxygen and nitrogen species (ROS, RNS) were performed and compared to Milli-Q water and culture media without and with ..
  25. Liao Y, Lee H, Huang W, Fan P, Chiou L. Hispidulin alleviated methamphetamine-induced hyperlocomotion by acting at α6 subunit-containing GABAA receptors in the cerebellum. Psychopharmacology (Berl). 2016;233:3187-99 pubmed publisher
    ..Hispidulin was shown to be a positive allosteric modulator (PAM) of GABAA receptors, including the α6 subunit-containing subtype (α6GABAAR) that is predominantly expressed in ..
  26. Dobrikova A, Yotsova E, Börner A, Landjeva S, Apostolova E. The wheat mutant DELLA-encoding gene (Rht-B1c) affects plant photosynthetic responses to cadmium stress. Plant Physiol Biochem. 2017;114:10-18 pubmed publisher
    ..photosynthetic apparatus of wheat seedlings grown on a nutrient solution were evaluated through a combination of PAM chlorophyll fluorescence, oxygen evolution, oxidation-reduction kinetics of P700 and 77 K fluorescence...
  27. Tolkach Y, Merseburger A, Herrmann T, Kuczyk M, Serth J, Imkamp F. Signatures of Adverse Pathological Features, Androgen Insensitivity and Metastatic Potential in Prostate Cancer. Anticancer Res. 2015;35:5443-51 pubmed
    ..component 6 (MCM6), marker of proliferation Ki-67 (MKI67), mucin 1, cell surface associated (MUC1), MYC binding protein 2, E3 ubiquitin protein ligase (MYCBP2), somatostatin receptor 1 (SSTR1), topoisomerase (DNA) II alpha 170 ..
  28. Rajwani J, Klinger C, Arango E, Arroyo M, Sabbagh A, Maestre A, et al. Genetic analysis of ID1-DBL2X predicts its validity as a vaccine candidate in Colombia and supports at least two independently introduced Plasmodium falciparum populations in the region. Infect Genet Evol. 2017;55:175-185 pubmed publisher
    Pregnancy-associated malaria (PAM) poses a threat to both the mother and fetus, increasing the risk of severe maternal anemia, fetal growth restriction and low birth weight infants...
  29. Facci L, Barbierato M, Zusso M, Skaper S, Giusti P. Serum amyloid A primes microglia for ATP-dependent interleukin-1β release. J Neuroinflammation. 2018;15:164 pubmed publisher
    ..Although the TLR2 antagonist CU-CPT22 was inactive against Apo-SAA, it also failed to block the TLR2 agonist Pam3CSK4...
  30. Barrenschee M, Lex D, Uhlig S. Effects of the TLR2 agonists MALP-2 and Pam3Cys in isolated mouse lungs. PLoS ONE. 2010;5:e13889 pubmed publisher
    ..Here we studied the effects of the TLR2/6 agonist MALP-2, the TLR2/1 agonist Pam(3)Cys and the TLR4 agonist lipopolysaccharide (LPS) on pro-inflammatory responses in isolated lungs...
  31. Tan T, Sun Y, Luo S, Zhang C, Zhou H, Lin H. Efficient modulation of photosynthetic apparatus confers desiccation tolerance in the resurrection plant Boea hygrometrica. Plant Cell Physiol. 2017;58:1976-1990 pubmed publisher
    ..Pulse-amplitude modulated (PAM) chlorophyll fluorescence measurements, P700 redox assay as well as chlorophyll fluorescence emission spectra ..
  32. Badal S, Turfus S, Rajnarayanan R, Wilson Clarke C, Sandiford S. Analysis of natural product regulation of opioid receptors in the treatment of human disease. Pharmacol Ther. 2018;184:51-80 pubmed publisher
    ..developing the 'Holy Grail' of analgesics, for example, ignavine, the natural μOR positive allosteric modulator (PAM) with codeine and the natural fascaplysin, a balanced agonist with fentanyl...
  33. Liu M, DU G, Liu B, Hu Y, Liu J, Jia Y, et al. Cholesterol exacerbates Mycoplasma hyopneumoniae-induced apoptosis via stimulating proliferation and adhesion to porcine alveolar macrophages. Vet Microbiol. 2017;211:112-118 pubmed publisher
    ..In conclusion, cholesterol promotes the apoptotic effect of M. hyo through stimulating proliferation and enhancing its adherence to PAMs. Hence, the study gives new insights into the role of cholesterol on the PAM - M. hyo interations.
  34. Burmistrz M, Dudek B, Staniec D, Rodriguez Martinez J, Bochtler M, Potempa J, et al. Functional Analysis of Porphyromonas gingivalis W83 CRISPR-Cas Systems. J Bacteriol. 2015;197:2631-41 pubmed publisher
    ..DNA constructs containing protospacer sequences accompanied at the 3' end by an NGG protospacer-adjacent motif (PAM). Most of the 44 spacers present in the genome of P...
  35. Zhang J, Miao J, Hou J, Lu C. The effects of H3N2 swine influenza virus infection on TLRs and RLRs signaling pathways in porcine alveolar macrophages. Virol J. 2015;12:61 pubmed publisher
    ..Western blotting showed that the protein levels of TLR-3, TLR-7 and RIG-I also had a significantly increase after PAM exposed to virus. A significant change of MyD88, MAVS, IRF-3 and IRF-7 mRNA expression were present at 8 hpi...
  36. Holzinger A, Herburger K, Kaplan F, Lewis L. Desiccation tolerance in the chlorophyte green alga Ulva compressa: does cell wall architecture contribute to ecological success?. Planta. 2015;242:477-92 pubmed publisher
    ..Imaging-PAM analysis demonstrated a homogenous desiccation process within individual thallus discs...
  37. Finnigan G, Thorner J. mCAL: A New Approach for Versatile Multiplex Action of Cas9 Using One sgRNA and Loci Flanked by a Programmed Target Sequence. G3 (Bethesda). 2016;6:2147-56 pubmed publisher
    ..at multiple loci involves: (i) identification of appropriate genomic sites, especially the availability of suitable PAM sequences; (ii) the design, construction, and expression of multiple sgRNA directed against those sites; (iii) ..
  38. Mangas I, Taylor P, Vilanova E, Estévez J, França T, Komives E, et al. Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches. Arch Toxicol. 2016;90:603-16 pubmed publisher
    ..Progressive reactivation was observed after Flu-MPs inhibition using oxime 2-PAM. However, no reactivation was observed after mipafox inhibition with 2-PAM or the more potent oximes used...
  39. Santillo M, Liu Y. A fluorescence assay for measuring acetylcholinesterase activity in rat blood and a human neuroblastoma cell line (SH-SY5Y). J Pharmacol Toxicol Methods. 2015;76:15-22 pubmed publisher
    ..in addition to inhibition, AChE reactivation was measured in SH-SY5Y cells incubated with pralidoxime chloride (2-PAM)...
  40. Wang L, Hu S, Liu Q, Li Y, Xu L, Zhang Z, et al. Porcine alveolar macrophage polarization is involved in inhibition of porcine reproductive and respiratory syndrome virus (PRRSV) replication. J Vet Med Sci. 2017;79:1906-1915 pubmed publisher
    ..Moreover, we found that M2 marker expression gradually increased after PAM infection with PRRSV, whereas no significant changes were found with M1 marker expression, suggesting that PRRSV ..
  41. Olbert C, Penn D, Reise S, Horan W, Kern R, Lee J, et al. Assessment of attachment in psychosis: A psychometric cause for concern. Psychiatry Res. 2016;246:77-83 pubmed publisher
    ..The current study examined the latent structure of the self-report Psychosis Attachment Measure (PAM) and its relationship to lower-level perceptual and higher-order inferential social cognitive processes...
  42. Boyle E, Andreasson J, Chircus L, Sternberg S, Wu M, Guegler C, et al. High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding. Proc Natl Acad Sci U S A. 2017;114:5461-5466 pubmed publisher
    ..nucleotides, both in the seed and in more distal nucleotides, plus disruption of the protospacer adjacent motif (PAM)...
  43. Niewoehner O, Jinek M. Specialized Weaponry: How a Type III-A CRISPR-Cas System Excels at Combating Phages. Cell Host Microbe. 2017;22:258-259 pubmed publisher
    ..In this issue of Cell Host & Microbe, Pyenson et al. (2017) show that the lack of a PAM requirement in some CRISPR-Cas systems prevents interference evasion and facilitates phage extinction.
  44. Ge Z, Guo X, Li J, Hartman M, Kawasawa Y, Dovat S, et al. Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia. Oncotarget. 2015;6:42300-11 pubmed publisher
    ..b>MYC binding protein 2 (MYCBP2) is a probable E3 ubiquitin ligase and its function in leukemia is unknown...
  45. Flores Molina M, Rautenberger R, Muñoz P, Huovinen P, Gomez I. Stress Tolerance of the Endemic Antarctic Brown Alga Desmarestia anceps to UV Radiation and Temperature is Mediated by High Concentrations of Phlorotannins. Photochem Photobiol. 2016;92:455-66 pubmed publisher
    ..Photosynthesis, measured by PAM-fluorometry, the contents of soluble phlorotannins, antioxidant capacities of field grown were analyzed in response ..
  46. Vollmer S, Strickson S, Zhang T, Gray N, Lee K, Rao V, et al. The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists. Biochem J. 2017;474:2027-2038 pubmed publisher
    ..Pellino1 was not increased significantly by stimulation with interleukin-1 (IL-1) in IL-1R-expressing HEK293 cells, Pam3CSK4-stimulated human THP1 monocytes or primary human macrophages...
  47. Nakamura K, Peng Y, Utsumi F, Tanaka H, Mizuno M, Toyokuni S, et al. Novel Intraperitoneal Treatment With Non-Thermal Plasma-Activated Medium Inhibits Metastatic Potential of Ovarian Cancer Cells. Sci Rep. 2017;7:6085 pubmed publisher
    ..Recently, plasma-activated medium (PAM) has been widely studied in various cancer types...
  48. Madjroh N, Olander E, Bundgaard C, Söderhielm P, Jensen A. Functional properties and mechanism of action of PPTQ, an allosteric agonist and low nanomolar positive allosteric modulator at GABAA receptors. Biochem Pharmacol. 2018;147:153-169 pubmed publisher
    ..and recreational drug methaqualone (Quaalude) is a moderately potent, non-selective positive allosteric modulator (PAM) at GABAA receptors (GABAARs) (Hammer et al., 2015)...
  49. Mirabella F, Murison A, Aronson L, Wardell C, Thompson A, Hanrahan S, et al. A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex. PLoS ONE. 2014;9:e99493 pubmed publisher
    ..Using RNA-seq we show that REIIBP influences the RNA splicing pattern of the cell. This new discovery provides novel insights into the understanding of MM pathology, and potential new leads for therapeutic targeting. ..
  50. Liu W, Zhou Y, Wang M, Li L, Vienneau E, Chen R, et al. Correcting the limited view in optical-resolution photoacoustic microscopy. J Biophotonics. 2017;: pubmed publisher
    Optical-resolution photoacoustic microscopy (OR-PAM) has proven useful for anatomical and functional imaging with high spatial resolutions...
  51. Yamano T, Zetsche B, Ishitani R, Zhang F, Nishimasu H, Nureki O. Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1. Mol Cell. 2017;67:633-645.e3 pubmed publisher
    ..Cpf1 requires a specific nucleotide sequence, called a protospacer adjacent motif (PAM), for target recognition. Besides the canonical TTTV PAM, Cpf1 recognizes suboptimal C-containing PAMs...
  52. Long M, Engers J, Chang S, Zhan X, Weiner R, Luscombe V, et al. Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping. Bioorg Med Chem Lett. 2017;27:4999-5001 pubmed publisher
    This Letter details our efforts to replace the 3-amino moiety, an essential pharmacophore for M4 PAM activity in most M4 PAMs to date, within the thieno[2,3-b]pyridine core, as the β-amino carboxamide motif has ..
  53. Liu G, Gao H, Zuo Y, Zeng X, Tao W, Tsai H, et al. DACHPt-Loaded Unimolecular Micelles Based on Hydrophilic Dendritic Block Copolymers for Enhanced Therapy of Lung Cancer. ACS Appl Mater Interfaces. 2017;9:112-119 pubmed publisher
    ..a hydrophilic and biodegradable dendritic block copolymer poly(amidoamine)-polyglutamic acid-b-polyethylene glycol (PAM-PGlu-b-PEG), which was composed of generation 3 PAMAM (PAMAM-G3), polyglutamic acid, and long-circulating polymer ..
  54. Liu Y, Lv C, Ding J, Qian P, Yu Y, Ye S, et al. Characterization of a hybrid polyacrylamide and its flocculation properties in cyanide tailing suspensions. Water Sci Technol. 2017;76:2482-2493 pubmed publisher
    An inorganic-organic hybrid flocculant Al(OH)3-polyacrylamide (Al-PAM) with narrow molecular weight distribution was synthesized using inverse microemulsion polymerization...
  55. Litti Y, Nikitina A, Kovalev D, Ermoshin A, Mahajan R, Goel G, et al. Influence of cationic Polyacrilamide Flocculant on high-solids anaerobic Digestion of Sewage Sludge under thermophilic Condition. Environ Technol. 2017;:1-26 pubmed publisher
    Treatment of sewage sludge (SS) by biodegradable polyacrylamide-based flocculants (PAM) is considered to be an effective way to increase total solids (TS) content prior to anaerobic digestion (AD)...
  56. Murthy V, Han S, Beauchamp R, Smith N, Haddad L, Ito N, et al. Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex. J Biol Chem. 2004;279:1351-8 pubmed
    ..Tuberin and hamartin function together as a complex in mammals and Drosophila. We report here the association of Pam, a protein identified as an interactor of Myc, with the tuberin-hamartin complex in the brain...
  57. Borghese C, Herman M, Snell L, Lawrence K, Lee H, Backos D, et al. Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes. Sci Rep. 2017;7:6230 pubmed publisher
    ..DCUK-OEt was shown to be a positive allosteric modulator (PAM) of GABA currents with α1β2γ2, α1β3γ2, α5β3γ2 and α1β3δ GABAA receptors, while having no ..
  58. Feng Y, Chen C, Han Y, Chen Z, Lu X, Liang F, et al. Expanding CRISPR/Cas9 Genome Editing Capacity in Zebrafish Using SaCas9. G3 (Bethesda). 2016;6:2517-21 pubmed publisher
    ..However, the requirement for the 5'-NGG-3' protospacer-adjacent motif (PAM) of Cas9 from Streptococcus pyogenes (SpCas9) limits its targeting sequences...
  59. Qiao D, Yu L, Bao X, Zhang B, Jiang F. Understanding the microstructure and absorption rate of starch-based superabsorbent polymers prepared under high starch concentration. Carbohydr Polym. 2017;175:141-148 pubmed publisher
    ..The increase in amylopectin reduced the amount (CPAM) of polyacrylamide (PAM) in starch-SAPs but increased the ratio of starch carbons grafted with PAM, which ..
  60. Davis G, Baumgartner M, Bonnell J, Bell J, Berchok C, Bort Thornton J, et al. Long-term passive acoustic recordings track the changing distribution of North Atlantic right whales (Eubalaena glacialis) from 2004 to 2014. Sci Rep. 2017;7:13460 pubmed publisher
    ..While so far visual data have provided most information on NARW movements, passive acoustic monitoring (PAM) was used in this study in order to better capture year-round NARW presence...
  61. Li N, Chen G, Chen W, Huang J, Tian J, Wan X, et al. Multivalent cations-triggered rapid shape memory sodium carboxymethyl cellulose/polyacrylamide hydrogels with tunable mechanical strength. Carbohydr Polym. 2017;178:159-165 pubmed publisher
    ..in a one-pot method, and interpenetrating double network was formed by chemically cross-linked polyacrylamide (PAM) network and physically cross-linked sodium carboxymethyl cellulose network...
  62. Guo K, Gao B, Li R, Wang W, Yue Q, Wang Y. Flocculation performance of lignin-based flocculant during reactive blue dye removal: comparison with commercial flocculants. Environ Sci Pollut Res Int. 2018;25:2083-2095 pubmed publisher
    ..LBF was less pH sensitive and shear sensitive than polyacrylamide (PAM) due to the enhanced charge neutralization and bridging action...
  63. Montalbano Di Filippo M, Novelletto A, Di Cave D, Berrilli F. Identification and phylogenetic position of Naegleria spp. from geothermal springs in Italy. Exp Parasitol. 2017;: pubmed publisher
    ..Among the recognized species, Naegleria fowleri causes primary amoebic meningoencephalitis (PAM), while two other species, Naegleria australiensis and Naegleria italica, have been reported as pathogenic in ..
  64. Zhao L, Li K, Wang Q, Song X, Su H, Xie B, et al. Nitrogen Starvation Impacts the Photosynthetic Performance of Porphyridium cruentum as Revealed by Chlorophyll a Fluorescence. Sci Rep. 2017;7:8542 pubmed publisher
    ..the effects of nitrogen deficiency on photosynthetic performance using a multi-color pulse amplitude modulation (PAM) chlorophyll fluorometer...
  65. Pyenson N, Gayvert K, Varble A, Elemento O, Marraffini L. Broad Targeting Specificity during Bacterial Type III CRISPR-Cas Immunity Constrains Viral Escape. Cell Host Microbe. 2017;22:343-353.e3 pubmed publisher
    ..For type I and II CRISPR-Cas systems, single-nucleotide mutations in the seed or protospacer adjacent motif (PAM) of the target sequence cause immune failure and allow viral escape...
  66. Windisch K, Czachowski C. Effects of group II metabotropic glutamate receptor modulation on ethanol- and sucrose-seeking and consumption in the rat. Alcohol. 2018;66:77-85 pubmed publisher
    ..Systemic administration of the selective mGluR2 PAM BINA, however, had no effect on either seeking or consumption of ethanol or sucrose...
  67. Giannella Neto A, Bellido C, Barbosa R, Melo M. Design and calibration of unicapillary pneumotachographs. J Appl Physiol (1985). 1998;84:335-43 pubmed
    ..Tests were done for conditions of ambient pressure (Pam) and positive pressure (Ppos) ventilation at different flow ranges...
  68. Liu Z, Wei H, Li A, Yang H. Evaluation of structural effects on the flocculation performance of a co-graft starch-based flocculant. Water Res. 2017;118:160-166 pubmed publisher
    ..by the co-graft polymerization of acrylamide and [(2-methacryloyloxyethyl) trimethyl ammonium chloride] (St-g-PAM-co-PDMC)...
  69. Niu J, Nie D, Yu D, Wu Q, Yu L, Yao Z, et al. Synthesis, fungicidal activity and phloem mobility of phenazine-1-carboxylic acid-alanine conjugates. Pestic Biochem Physiol. 2017;143:8-13 pubmed publisher
    ..In vitro and planta bioassays results showed that conjugates L-PAM and D-PAM exhibited higher fungicidal activities against Rhizoctonia solani Kuhn than PCA while L-PA and D-PA were ..
  70. James G, Key B, Beverdam A. The E3 ubiquitin ligase Mycbp2 genetically interacts with Robo2 to modulate axon guidance in the mouse olfactory system. Brain Struct Funct. 2014;219:861-74 pubmed publisher
    The E3 ubiquitin ligase Mycbp2 and it homologues play an important role in axon guidance and synaptogenesis in Drosophila, Caenorhabditis elegans, zebrafish and mouse...
  71. Bredrup C, Johansson S, Bindoff L, Sztromwasser P, Kråkenes J, Mellgren A, et al. High myopia-excavated optic disc anomaly associated with a frameshift mutation in the MYC-binding protein 2 gene (MYCBP2). Am J Ophthalmol. 2015;159:973-9.e2 pubmed publisher
    ..Exome sequencing revealed that the father was heterozygous for a de novo 5 bp deletion in MYCBP2, c.5906_5910del; p.Glu1969Valfs*26...
  72. Yang H, Gao P, Rajashankar K, Patel D. PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease. Cell. 2016;167:1814-1828.e12 pubmed publisher
    ..Notably, the PAM-interacting cleft adopts a "locked" conformation on ternary complex formation...
  73. Bewley B, Spearing P, Weiner R, Luscombe V, Zhan X, Chang S, et al. Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core. Bioorg Med Chem Lett. 2017;27:4274-4279 pubmed publisher
    This Letter details the discovery and subsequent optimization of a novel M4 PAM scaffold based on an 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core, which represents a distinct departure from the classical M4
  74. Ghanchi N, Jamil B, Khan E, Ansar Z, Samreen A, Zafar A, et al. Case Series of Naegleria fowleri Primary Ameobic Meningoencephalitis from Karachi, Pakistan. Am J Trop Med Hyg. 2017;97:1600-1602 pubmed publisher
    i>Naegleria fowleri causes primary amoebic meningoencephalitis (PAM) which is almost always fatal...
  75. Xu M, Zhu C, Zhao X, Chen C, Zhang H, Yuan H, et al. Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors. Oncotarget. 2015;6:979-94 pubmed
    ..Here, we find that EMT-TFs can be dynamically degraded by an atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 (SPFFbxo45) through the ubiquitin proteasome system (UPS)...
  76. Meacham K, Sirault X, Quick W, von Caemmerer S, Furbank R. Diurnal Solar Energy Conversion and Photoprotection in Rice Canopies. Plant Physiol. 2017;173:495-508 pubmed publisher
    ..The pulse amplitude modulated chlorophyll fluorescence technique (PAM) allows quantitative leaf level monitoring of the utilization of energy for photochemical light conversion and ..
  77. Martínez A, Bono C, Megías J, Yáñez A, Gozalbo D, Gil M. PRR signaling during in vitro macrophage differentiation from progenitors modulates their subsequent response to inflammatory stimuli. Eur Cytokine Netw. 2017;28:102-110 pubmed publisher
    ..macrophage differentiation in the presence or absence of the following pattern recognition receptor (PRR) agonists: Pam3CSK4 (TLR2 ligand), LPS (TLR4 ligand), depleted zymosan (which only activates Dectin-1), or ..
  78. Chen K, Malo M, Moss A, Zeller S, Johnson P, Ebrahimi F, et al. Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase. Am J Physiol Gastrointest Liver Physiol. 2010;299:G467-75 pubmed publisher
    ..coli, Salmonella typhimurium, and Listeria monocytogenes), and a variety of proinflammatory ligands (LPS, CpG DNA, Pam-3-Cys, flagellin, and TNF) were incubated with or without calf IAP (cIAP)...
  79. Ma J, Fu K, Shi J, Sun Y, Zhang X, Ding L. Ultraviolet-assisted synthesis of polyacrylamide-grafted chitosan nanoparticles and flocculation performance. Carbohydr Polym. 2016;151:565-575 pubmed publisher
    In the present work, a new flocculant, polyacrylamide-grafted chitosan nanoparticles (NCS-g-PAM), was synthesized by the copolymerization of acrylamide (AM) and chitosan nanoparticle (NCS) under ultraviolet irradiation using 2-hydroxy-4'-..
  80. Kane N, Vora M, Varre K, Padgett R. Efficient Screening of CRISPR/Cas9-Induced Events in Drosophila Using a Co-CRISPR Strategy. G3 (Bethesda). 2017;7:87-93 pubmed publisher
    ..Using two different PAM sites in our gene of interest, we report that ?61% (52-70%) of flies from the ebony-enriched broods had an indel in ..
  81. Lapointe M, Barbeau B. Dual starch-polyacrylamide polymer system for improved flocculation. Water Res. 2017;124:202-209 pubmed publisher
    Organic polyelectrolytes such as polyacrylamide (PAM) are commonly used in the water industry to improve flocculation...
  82. Cai H, Orwenyo J, Giddens J, Yang Q, Zhang R, LaBranche C, et al. Synthetic Three-Component HIV-1 V3 Glycopeptide Immunogens Induce Glycan-Dependent Antibody Responses. Cell Chem Biol. 2017;24:1513-1522.e4 pubmed publisher
    ..immunogen that consists of a 33-mer V3 glycopeptide epitope, a universal T helper epitope P30, and a lipopeptide (Pam3CSK4) that serves as a ligand of Toll-like receptor 2...
  83. Yoo H, Kim M, Kim M, Chae J, Lee S, Lee J. The peptidylglycine-?-amidating monooxygenase (PAM) gene rs13175330 A>G polymorphism is associated with hypertension in a Korean population. Hum Genomics. 2017;11:29 pubmed publisher
    Peptidylglycine-?-amidating monooxygenase (PAM) may play a role in the secretion of atrial natriuretic peptide (ANP), which is a hormone involved in the maintenance of blood pressure (BP)...
  84. Yoshimura R, Tran M, Hogenkamp D, Ayala N, Johnstone T, Dunnigan A, et al. Allosteric modulation of nicotinic and GABAA receptor subtypes differentially modify autism-like behaviors in the BTBR mouse model. Neuropharmacology. 2017;126:38-47 pubmed publisher
    ..containing GABAA receptor (GABAAR) subtype selective positive allosteric modulator (PAM), 2-261, and an ?7 nAChR subtype selective PAM, AVL-3288, were tested in social approach and repetitive self-..
  85. Mohammadi H, Jalilian J, Karimi M, Shetab Boushehri S. In Vitro Cysteine Reactivates Organophosphate Insecticide Dichlorvos-Inhibited Human Cholinesterases. Sultan Qaboos Univ Med J. 2017;17:e293-e300 pubmed publisher
    ..Oximes, especially pralidoxime (2-PAM), are widely used as antidotes to treat OP poisoning...
  86. Hosseini S, Moghimi A, Iman M, Ebrahimi F. Docking Studies, Synthesis, and In-vitro Evaluation of Novel Oximes Based on Nitrones as Reactivators of Inhibited Acetylcholinesterase. Iran J Pharm Res. 2017;16:880-892 pubmed
    ..i>in-vitro on human AChE (hAChE) inhibited by paraoxon and compared to standard hAChE reactivators (2-PAM and obidoxime). Our results used to design new derivatives of Oxim with better efficacy than 2-PAM and obidoxime...
  87. Cui Y, Matsubara T, Sugimoto K. Kernel dynamic policy programming: Applicable reinforcement learning to robot systems with high dimensional states. Neural Netw. 2017;94:13-23 pubmed publisher
    ..robot system, KDPP successfully learned the task of unscrewing a bottle cap via a Pneumatic Artificial Muscle (PAM) driven robotic hand with tactile sensors; a system with a state space of 32 dimensions, while given limited ..
  88. Yagi H. Initial treatment strategy for patients newly diagnosed with multiple myeloma. Rinsho Ketsueki. 2017;58:2050-2057 pubmed publisher
    ..who have normal cardiac and lung functions without any serious complications are good candidates for high-dose L-PAM with autologous stem cell transplantation...
  89. Bretin S, Krazem A, Henkous N, Froger Colleaux C, Mocaer E, Louis C, et al. Synergistic enhancing-memory effect of donepezil and S 47445, an AMPA positive allosteric modulator, in middle-aged and aged mice. Psychopharmacology (Berl). 2018;235:771-787 pubmed publisher
    ..Among them, S 47445 is a novel potent and selective AMPA-PAM. In order to assess its efficacy after repeated administration, S 47445 effect was evaluated in two aging-induced ..
  90. Sun Y, Ren M, Sun W, Xiao X, Xu Y, Zheng H, et al. Plasma-induced synthesis of chitosan-g-polyacrylamide and its flocculation performance for algae removal. Environ Technol. 2017;:1-26 pubmed publisher
    Chitosan (CS)-g-polyacrylamide (PAM) is a highly efficient and environmentally friendly flocculant, which was synthesized through plasma-induced graft copolymerization of CS and acrylamide (AM)...
  91. Nguyen T, DiGiovanna J, Cavuscens S, Ranieri M, Guinand N, van de Berg R, et al. Characterization of pulse amplitude and pulse rate modulation for a human vestibular implant during acute electrical stimulation. J Neural Eng. 2016;13:046023 pubmed publisher
    ..However, optimal electrical stimulation strategies have not yet been identified in patients. In this study, we compared the two most common strategies, pulse amplitude modulation (PAM) and pulse rate modulation (PRM), in patients.
  92. Yang J, Gong L, Xu X, Hai P, Shen Y, Suzuki Y, et al. Motionless volumetric photoacoustic microscopy with spatially invariant resolution. Nat Commun. 2017;8:780 pubmed publisher
    Photoacoustic microscopy (PAM) is uniquely positioned for biomedical applications because of its ability to visualize optical absorption contrast in vivo in three dimensions...