MYB

Summary

Gene Symbol: MYB
Description: MYB proto-oncogene, transcription factor
Alias: Cmyb, c-myb, c-myb_CDS, efg, transcriptional activator Myb, oncogene AMV, proto-oncogene c-Myb, v-myb avian myeloblastosis viral oncogene homolog
Species: human
Products:     MYB

Top Publications

  1. Wonkam A, Ngo Bitoungui V, Vorster A, Ramesar R, Cooper R, Tayo B, et al. Association of variants at BCL11A and HBS1L-MYB with hemoglobin F and hospitalization rates among sickle cell patients in Cameroon. PLoS ONE. 2014;9:e92506 pubmed publisher
    ..SNPs in HBS1L-MYB region (HMIP) likewise had a significant impact on HbF, however, we did not find an association between HbF and the ..
  2. Kurahashi T, Nomura T, Kanei Ishii C, Shinkai Y, Ishii S. The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3. Mol Biol Cell. 2005;16:4705-13 pubmed
    The c-myb proto-oncogene product (c-Myb) regulates proliferation and differentiation of hematopoietic cells...
  3. Sramko M, Markus J, Kabat J, Wolff L, Bies J. Stress-induced inactivation of the c-Myb transcription factor through conjugation of SUMO-2/3 proteins. J Biol Chem. 2006;281:40065-75 pubmed
    ..and SUMOylation, play an important role in regulation of the stability and the transcriptional activity of c-Myb. Conjugation of small ubiquitin-like modifier type 1 (SUMO-1) to lysines in the negative regulatory domain strongly ..
  4. Drabsch Y, Robert R, Gonda T. MYB suppresses differentiation and apoptosis of human breast cancer cells. Breast Cancer Res. 2010;12:R55 pubmed publisher
    b>MYB is highly expressed in estrogen receptor positive (ER + ve) breast tumours and tumour cell lines...
  5. Thompson M, Rosenthal M, Ellis S, Friend A, Zorbas M, Whitehead R, et al. c-Myb down-regulation is associated with human colon cell differentiation, apoptosis, and decreased Bcl-2 expression. Cancer Res. 1998;58:5168-75 pubmed
    c-myb is expressed in human and murine colonic mucosa and elevated expression occurs in premalignant adenomatous polyps and carcinomas...
  6. Quintana A, Zhou Y, Pena J, O Rourke J, Ness S. Dramatic repositioning of c-Myb to different promoters during the cell cycle observed by combining cell sorting with chromatin immunoprecipitation. PLoS ONE. 2011;6:e17362 pubmed publisher
    The c-Myb transcription factor is a critical regulator of proliferation and stem cell differentiation, and mutated alleles of c-Myb are oncogenic, but little is known about changes in c-Myb activity during the cell cycle...
  7. Westin E, Gallo R, Arya S, Eva A, Souza L, Baluda M, et al. Differential expression of the amv gene in human hematopoietic cells. Proc Natl Acad Sci U S A. 1982;79:2194-8 pubmed
    ..Expression of c-amv could not be correlated with the extent of methylation in HL60 and in HL60 induced to differentiate with dimethyl sulfoxide. ..
  8. Cai W, Li Q, Yang Z, Miao X, Wen Y, Huang S, et al. Expression of p53 upregulated modulator of apoptosis (PUMA) and C-myb in gallbladder adenocarcinoma and their pathological significance. Clin Transl Oncol. 2013;15:818-24 pubmed publisher
    An increasing number of studies have shown that PUMA and C-myb signaling pathways are involved in various human cancers including colon carcinomas...
  9. Cesi V, Casciati A, Sesti F, Tanno B, Calabretta B, Raschellà G. TGF?-induced c-Myb affects the expression of EMT-associated genes and promotes invasion of ER+ breast cancer cells. Cell Cycle. 2011;10:4149-61 pubmed publisher
    ..Advanced breast cancer cells acquire metastatic properties in response to TGF?. We show here that the expression of c-Myb increases in TGF?-treated ER (+) breast cancer cells by protein stabilization, transcription activation and release ..

More Information

Publications72

  1. Verbeek W, Gombart A, Chumakov A, Muller C, Friedman A, Koeffler H. C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters. Blood. 1999;93:3327-37 pubmed
    ..T lymphoblasts (Jurkat cells) and immature myeloid cells (eg, Kcl22 cells) expressed high levels of the c-myb hematopoietic transcription factor...
  2. Bhattarai G, Lee Y, Lee N, Yun J, Hwang P, Yi H. c-myb mediates inflammatory reaction against oxidative stress in human breast cancer cell line, MCF-7. Cell Biochem Funct. 2011;29:686-93 pubmed publisher
    ..This study examined the contribution of proto-oncogene c-myb to inflammation in MCF-7 breast cancer cells...
  3. O Neil J, Tchinda J, Gutierrez A, Moreau L, Maser R, WONG K, et al. Alu elements mediate MYB gene tandem duplication in human T-ALL. J Exp Med. 2007;204:3059-66 pubmed
    Recent studies have demonstrated that the MYB oncogene is frequently duplicated in human T cell acute lymphoblastic leukemia (T-ALL)...
  4. Lei W, Liu F, Ness S. Positive and negative regulation of c-Myb by cyclin D1, cyclin-dependent kinases, and p27 Kip1. Blood. 2005;105:3855-61 pubmed
    The c-Myb transcription factor controls differentiation and proliferation in hematopoietic and other cell types and has latent transforming activity, but little is known about its regulation during the cell cycle...
  5. Kanei Ishii C, Ninomiya Tsuji J, Tanikawa J, Nomura T, Ishitani T, Kishida S, et al. Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev. 2004;18:816-29 pubmed
    The c-myb proto-oncogene product (c-Myb) regulates both the proliferation and apoptosis of hematopoietic cells by inducing the transcription of a group of target genes...
  6. Makani J, Menzel S, Nkya S, Cox S, Drasar E, Soka D, et al. Genetics of fetal hemoglobin in Tanzanian and British patients with sickle cell anemia. Blood. 2011;117:1390-2 pubmed publisher
    ..Genetic variation at 3 principal loci (HBB cluster on chromosome 11p, HBS1L-MYB region on chromosome 6q, and BCL11A on chromosome 2p) have been shown to influence HbF levels and disease severity ..
  7. Sano Y, Ishii S. Increased affinity of c-Myb for CREB-binding protein (CBP) after CBP-induced acetylation. J Biol Chem. 2001;276:3674-82 pubmed
    The c-myb proto-oncogene product (c-Myb) is a sequence-specific DNA-binding protein that functions as a transcriptional activator...
  8. Nicolaides N, Gualdi R, Casadevall C, Manzella L, Calabretta B. Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb gene. Mol Cell Biol. 1991;11:6166-76 pubmed
    The nuclear proto-oncogene c-myb is preferentially expressed in lymphohematopoietic cells, in which it plays an important role in the processes of differentiation and proliferation...
  9. Lu H, Wang Y, Huang Y, Shi H, Xue Q, Yang S, et al. Expression and prognostic role of c-Myb as a novel cell cycle protein in esophageal squamous cell carcinoma. Clin Transl Oncol. 2013;15:796-801 pubmed publisher
    The c-Myb transcription factor controls differentiation and proliferation in hematopoietic and other cell types, and has latent in regulation during the cell cycle...
  10. Quintana A, Liu F, O Rourke J, Ness S. Identification and regulation of c-Myb target genes in MCF-7 cells. BMC Cancer. 2011;11:30 pubmed publisher
    The c-Myb transcription factor regulates differentiation and proliferation in hematopoietic cells, stem cells and epithelial cells...
  11. Mitani Y, Li J, Rao P, Zhao Y, Bell D, Lippman S, et al. Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance. Clin Cancer Res. 2010;16:4722-31 pubmed publisher
    The objectives of this study were to determine the incidence of the MYB-NFIB fusion in salivary adenoid cystic carcinoma (ACC), to establish the clinicopathologic significance of the fusion, and to analyze the expression of MYB in ACCs ..
  12. Sakamoto H, Dai G, Tsujino K, Hashimoto K, Huang X, Fujimoto T, et al. Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development. Blood. 2006;108:896-903 pubmed
    ..c-Myb is a transcription factor that is essential for the development of definitive hematopoiesis...
  13. Bianchi E, Zini R, Salati S, Tenedini E, Norfo R, Tagliafico E, et al. c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression. Blood. 2010;116:e99-110 pubmed publisher
    The c-myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation...
  14. Jiang J, Best S, Menzel S, Silver N, Lai M, Surdulescu G, et al. cMYB is involved in the regulation of fetal hemoglobin production in adults. Blood. 2006;108:1077-83 pubmed
    ..Five protein-coding genes, ALDH8A1, HBS1L, cMYB, AHI1, and PDE7B reside in this 1.5-megabase (Mb) candidate interval of 6q23...
  15. Slamon D, Boone T, Murdock D, Keith D, Press M, Larson R, et al. Studies of the human c-myb gene and its product in human acute leukemias. Science. 1986;233:347-51 pubmed
    The myb gene is the transforming oncogene of the avian myeloblastosis virus (AMV); its normal cellular homolog, c-myb, is conserved across a broad span of evolution...
  16. Oh I, Reddy E. The myb gene family in cell growth, differentiation and apoptosis. Oncogene. 1999;18:3017-33 pubmed
    The myb gene family consists of three members, named A, B and c-myb which encode nuclear proteins that function as transcriptional transactivators...
  17. Mitani Y, Rao P, Futreal P, Roberts D, Stephens P, Zhao Y, et al. Novel chromosomal rearrangements and break points at the t(6;9) in salivary adenoid cystic carcinoma: association with MYB-NFIB chimeric fusion, MYB expression, and clinical outcome. Clin Cancer Res. 2011;17:7003-14 pubmed publisher
    ..b>MYB mRNA expression level was determined by quantitative RT-PCR...
  18. Ferreira M, Hottenga J, Warrington N, Medland S, Willemsen G, Lawrence R, et al. Sequence variants in three loci influence monocyte counts and erythrocyte volume. Am J Hum Genet. 2009;85:745-9 pubmed publisher
    ..001, 9.9x10(-5), and 7x10(-5), respectively). The identification of these QTL provides new opportunities for furthering our understanding of the mechanisms regulating hemopoietic cell fate. ..
  19. Tomita A, Towatari M, Tsuzuki S, Hayakawa F, Kosugi H, Tamai K, et al. c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300. Oncogene. 2000;19:444-51 pubmed
    Transcription factor c-Myb plays important roles in cell survival and differentiation in immature hematopoietic cells...
  20. Xiao C, Calado D, Galler G, Thai T, Patterson H, Wang J, et al. MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell. 2007;131:146-59 pubmed
    ..A top predicted target of miR-150 is c-Myb, a transcription factor controlling multiple steps of lymphocyte development...
  21. Gudbjartsson D, Bjornsdottir U, Halapi E, Helgadottir A, Sulem P, Jonsdottir G, et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet. 2009;41:342-7 pubmed publisher
    ..SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4...
  22. Galanello R, Sanna S, Perseu L, Sollaino M, Satta S, Lai M, et al. Amelioration of Sardinian beta0 thalassemia by genetic modifiers. Blood. 2009;114:3935-7 pubmed publisher
    ..Here we evaluate the contribution of variants in the BCL11A, and HBS1L-MYB genes, implicated in the regulation of fetal hemoglobin, and of alpha-thalassemia coinheritance in 50 thalassemia ..
  23. Knopfova L, Benes P, Pekarčíková L, Hermanova M, Masarik M, Pernicová Z, et al. c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis. Mol Cancer. 2012;11:15 pubmed publisher
    The c-Myb transcription factor is essential for the maintenance of stem-progenitor cells in bone marrow, colon epithelia, and neurogenic niches. c-Myb malfunction contributes to several types of malignancies including breast cancer...
  24. O Rourke J, Ness S. Alternative RNA splicing produces multiple forms of c-Myb with unique transcriptional activities. Mol Cell Biol. 2008;28:2091-101 pubmed publisher
    The c-Myb transcription factor regulates the proliferation and differentiation of hematopoietic cells, and activated alleles of c-myb induce leukemias and lymphomas in animals...
  25. Tanno B, Negroni A, Vitali R, Pirozzoli M, Cesi V, Mancini C, et al. Expression of insulin-like growth factor-binding protein 5 in neuroblastoma cells is regulated at the transcriptional level by c-Myb and B-Myb via direct and indirect mechanisms. J Biol Chem. 2002;277:23172-80 pubmed
    ..Upon conditional expression of c-Myb in a NB cell line, we detected up-regulation of IGF1, IGF1 receptor, and insulin-like growth factor-binding protein ..
  26. Hugo H, Cures A, Suraweera N, Drabsch Y, Purcell D, Mantamadiotis T, et al. Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers. Genes Chromosomes Cancer. 2006;45:1143-54 pubmed
    Although MYB overexpression in colorectal cancer (CRC) is known to be a prognostic indicator for poor survival, the basis for this overexpression is unclear...
  27. Saether T, Pattabiraman D, Alm Kristiansen A, Vogt Kielland L, Gonda T, Gabrielsen O. A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability. Oncogene. 2011;30:212-22 pubmed publisher
    c-Myb is an essential hematopoietic transcription factor that controls proliferation and differentiation of progenitors during blood cell development...
  28. Greco C, Alvino S, Buglioni S, Assisi D, Lapenta R, Grassi A, et al. Activation of c-MYC and c-MYB proto-oncogenes is associated with decreased apoptosis in tumor colon progression. Anticancer Res. 2001;21:3185-92 pubmed
    ..during transition adenoma-to-carcinoma of the colorectal tract and the incidence of activation of c-myc and c-myb proto-oncogenes, involved both in colon tumorigenesis and apoptosis...
  29. Farrell J, Sherva R, Chen Z, Luo H, Chu B, Ha S, et al. A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression. Blood. 2011;117:4935-45 pubmed publisher
    Fetal hemoglobin (HbF) is regulated as a multigenic trait. By genome-wide association study, we confirmed that HBS1L-MYB intergenic polymorphisms (HMIP) and BCL11A polymorphisms are highly associated with HbF in Chinese ?-thalassemia ..
  30. Nakata Y, Shetzline S, Sakashita C, Kalota A, Rallapalli R, Rudnick S, et al. c-Myb contributes to G2/M cell cycle transition in human hematopoietic cells by direct regulation of cyclin B1 expression. Mol Cell Biol. 2007;27:2048-58 pubmed
    b>Myb family proteins are ubiquitously expressed transcription factors...
  31. Corradini F, Cesi V, Bartella V, Pani E, Bussolari R, Candini O, et al. Enhanced proliferative potential of hematopoietic cells expressing degradation-resistant c-Myb mutants. J Biol Chem. 2005;280:30254-62 pubmed
    The c-myb gene encodes a transcription factor required for proliferation, differentiation, and survival of hematopoietic cells...
  32. Fang F, Rycyzyn M, Clevenger C. Role of c-Myb during prolactin-induced signal transducer and activator of transcription 5a signaling in breast cancer cells. Endocrinology. 2009;150:1597-606 pubmed publisher
    ..These analyses revealed a PRL-inducible association of Stat5a with the transcription factor and protooncogene c-Myb. Confirmatory co-immunoprecipitation studies using lysates from both T47D and MCF7 breast cancer cells revealed a ..
  33. Jin W, Liu Y, Chen L, Zhu H, Di G, Ling H, et al. Involvement of MyoD and c-myb in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene. Breast Cancer Res Treat. 2011;125:699-713 pubmed publisher
    ..that MyoD expression and BRCA1 expression is correlated in sporadic breast tumors, overexpression of MyoD and c-myb stimulates BRCA1 expression, knockdown of MyoD and c-myb attenuates BRCA1 expression and attenuates the ability of ..
  34. Fahl S, Crittenden R, Allman D, Bender T. c-Myb is required for pro-B cell differentiation. J Immunol. 2009;183:5582-92 pubmed publisher
    The c-Myb transcription factor is required for normal adult hematopoiesis. However, the embryonic lethality of Myb-null mutations has been an impediment to identifying roles for c-Myb during lymphocyte development...
  35. Gonda T, Leo P, Ramsay R. Estrogen and MYB in breast cancer: potential for new therapies. Expert Opin Biol Ther. 2008;8:713-7 pubmed
    b>MYB is highly expressed in almost all estrogen receptor (ER)-positive breast tumours and is a direct target of estrogen/ER signalling...
  36. Dash A, Orrico F, Ness S. The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb. Genes Dev. 1996;10:1858-69 pubmed
    The c-Myb transcription factor is a proto-oncoprotein whose latent transforming activity can be unmasked by truncation of either terminus...
  37. Zhao H, Kalota A, Jin S, Gewirtz A. The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells. Blood. 2009;113:505-16 pubmed publisher
    The c-myb proto-oncogene encodes an obligate hematopoietic cell transcription factor important for lineage commitment, proliferation, and differentiation...
  38. Bies J, Markus J, Wolff L. Covalent attachment of the SUMO-1 protein to the negative regulatory domain of the c-Myb transcription factor modifies its stability and transactivation capacity. J Biol Chem. 2002;277:8999-9009 pubmed
    The transcription factor c-Myb is subject to several types of post-translational modifications, including phosphorylation, acetylation, and ubiquitination...
  39. Dahle Ø, Andersen T, Nordgård O, Matre V, Del Sal G, Gabrielsen O. Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner. Eur J Biochem. 2003;270:1338-48 pubmed
    The transcription factor v-Myb is a potent inducer of myeloid leukemias, and its cellular homologue c-Myb plays a crucial role in the regulation of hematopoiesis. Recently, Bies and coworkers (Bies, J., Markus, J. & Wolff, L...
  40. Lettre G, Sankaran V, Bezerra M, Araújo A, Uda M, Sanna S, et al. DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc Natl Acad Sci U S A. 2008;105:11869-74 pubmed publisher
    ..Common single nucleotide polymorphisms (SNPs) at the BCL11A and HBS1L-MYB loci have been implicated previously in HbF level variation in nonanemic European populations...
  41. Drabsch Y, Hugo H, Zhang R, Dowhan D, Miao Y, Gewirtz A, et al. Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells. Proc Natl Acad Sci U S A. 2007;104:13762-7 pubmed
    b>MYB (the human ortholog of c-myb) is expressed in a high proportion of human breast tumors, and that expression correlates strongly with estrogen receptor (ER) positivity...
  42. Westin E, Gorse K, Clarke M. Alternative splicing of the human c-myb gene. Oncogene. 1990;5:1117-24 pubmed
    Two cDNA clones of the human c-myb gene have been isolated from a CCRF-CEM leukemia cell cDNA library and sequenced in their entirety...
  43. Dasgupta P, Reddy E. Identification of alternatively spliced transcripts for human c-myb: molecular cloning and sequence analysis of human c-myb exon 9A sequences. Oncogene. 1989;4:1419-23 pubmed
    The murine c-myb gene has been recently shown to code for two protein products of 75kd and 89kd...
  44. Saether T, Berge T, Ledsaak M, Matre V, Alm Kristiansen A, Dahle O, et al. The chromatin remodeling factor Mi-2alpha acts as a novel co-activator for human c-Myb. J Biol Chem. 2007;282:13994-4005 pubmed
    The c-Myb protein belongs to a group of early hematopoietic transcription factors that are important for progenitor generation and proliferation...
  45. Lahortiga I, De Keersmaecker K, Van Vlierberghe P, Graux C, Cauwelier B, Lambert F, et al. Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. Nat Genet. 2007;39:593-5 pubmed
    We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines...
  46. Chen R, Xia Y, Xue T, Ye S. Transcription factor c-Myb promotes the invasion of hepatocellular carcinoma cells via increasing osteopontin expression. J Exp Clin Cancer Res. 2010;29:172 pubmed publisher
    ..mobility shift assays (EMSA) and reporter gene assays showed that one of up-regulated transcription factors c-Myb could bind the OPN promoter and increase its transcription activity...
  47. Clappier E, Cuccuini W, Kalota A, Crinquette A, Cayuela J, Dik W, et al. The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children. Blood. 2007;110:1251-61 pubmed
    The C-Myb transcription factor is essential for hematopoiesis, including in the T-cell lineage...
  48. Menzel S, Jiang J, Silver N, Gallagher J, Cunningham J, Surdulescu G, et al. The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans. Blood. 2007;110:3624-6 pubmed
    Common sequence variants situated between the HBS1L and MYB genes on chromosome 6q23.3 (HMIP) influence the proportion of F cells (erythrocytes that carry measurable amounts of fetal hemoglobin)...
  49. Deisenroth C, Thorner A, Enomoto T, Perou C, Zhang Y. Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53. Mol Cell Biol. 2010;30:3981-93 pubmed publisher
    ..In addition, Hep27 is regulated at the transcriptional level by the proto-oncogene c-Myb and is required for c-Myb-induced p53 stabilization...
  50. Kanei Ishii C, Nomura T, Takagi T, Watanabe N, Nakayama K, Ishii S. Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation. J Biol Chem. 2008;283:30540-8 pubmed publisher
    The c-myb proto-oncogene product (c-Myb) is degraded in response to Wnt-1 signaling via a pathway involving TAK1 (transforming growth factor-beta-activated kinase 1), HIPK2 (homeodomain-interacting protein kinase 2), and NLK (Nemo-like ..
  51. Creary L, Ulug P, Menzel S, McKenzie C, Hanchard N, Taylor V, et al. Genetic variation on chromosome 6 influences F cell levels in healthy individuals of African descent and HbF levels in sickle cell patients. PLoS ONE. 2009;4:e4218 pubmed publisher
    ..polymorphisms (SNPs) in a 24-kb intergenic region, 33-kb upstream of the HBS1L gene and 80-kb upstream of the MYB gene, were typed in 177 healthy Afro-Caribbean subjects (AC) of approximately 7% European admixture, 631 healthy ..
  52. Matre V, Nordgård O, Alm Kristiansen A, Ledsaak M, Gabrielsen O. HIPK1 interacts with c-Myb and modulates its activity through phosphorylation. Biochem Biophys Res Commun. 2009;388:150-4 pubmed publisher
    The transcription factor v-Myb is a potent inducer of myeloid leukaemias, and its cellular homologue c-Myb plays a crucial role in the regulation of haematopoiesis...
  53. Alm Kristiansen A, Saether T, Matre V, Gilfillan S, Dahle O, Gabrielsen O. FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci. Oncogene. 2008;27:4644-56 pubmed publisher
    The c-Myb oncoprotein is a DNA-binding transcription factor with a key role in early stages of hematopoiesis...
  54. Kitagawa K, Hiramatsu Y, Uchida C, Isobe T, Hattori T, Oda T, et al. Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb. Oncogene. 2009;28:2393-405 pubmed publisher
    Expression of oncoprotein c-Myb oscillates during hematopoiesis and hematological malignancies...
  55. Lin Y, Kuo M, Yu J, Kuo H, Lin R, Lo W, et al. c-Myb is an evolutionary conserved miR-150 target and miR-150/c-Myb interaction is important for embryonic development. Mol Biol Evol. 2008;25:2189-98 pubmed publisher
    Human c-Myb proto-oncogene is highly expressed in hematopoietic progenitors as well as leukemia and certain solid tumor. However, the regulatory mechanisms of its expression and biological functions remain largely unclear...
  56. Tanno B, Sesti F, Cesi V, Bossi G, Ferrari Amorotti G, Bussolari R, et al. Expression of Slug is regulated by c-Myb and is required for invasion and bone marrow homing of cancer cells of different origin. J Biol Chem. 2010;285:29434-45 pubmed publisher
    ..myeloid leukemia-blast crisis, and in neuroblastoma cells, expression of Slug is transcriptionally regulated by c-Myb via Myb binding sites in the 5'-flanking region and in the first intron of the slug gene...
  57. Lefebvre C, Rajbhandari P, Alvarez M, Bandaru P, Lim W, Sato M, et al. A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers. Mol Syst Biol. 2010;6:377 pubmed publisher
    ..in B cells, the human B-cell interactome (HBCI), reveals a hierarchical, transcriptional control module, where MYB and FOXM1 act as synergistic master regulators of proliferation in the germinal center (GC)...
  58. Sandberg M, Sutton S, Pletcher M, Wiltshire T, Tarantino L, Hogenesch J, et al. c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev Cell. 2005;8:153-66 pubmed
    ..a mouse line that harbors a point mutation in the transactivation (TA) domain of the transcription factor c-Myb (M303V), which reduces c-Myb-dependent TA by disrupting its interaction with the transcriptional coactivator p300...
  59. Jin S, Zhao H, Yi Y, Nakata Y, Kalota A, Gewirtz A. c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. J Clin Invest. 2010;120:593-606 pubmed publisher
    ..Recent data suggest that the MYB proto-oncogene, which is an important regulator of hematopoietic cell development, has a role in leukemogenesis ..
  60. Persson M, Andrén Y, Mark J, Horlings H, Persson F, Stenman G. Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. Proc Natl Acad Sci U S A. 2009;106:18740-4 pubmed publisher
    The transcription factor gene MYB was identified recently as an oncogene that is rearranged/duplicated in some human leukemias. Here we describe a new mechanism of activation of MYB in human cancer involving gene fusion...
  61. Dalla Favera R, Franchini G, Martinotti S, Wong Staal F, Gallo R, Croce C. Chromosomal assignment of the human homologues of feline sarcoma virus and avian myeloblastosis virus onc genes. Proc Natl Acad Sci U S A. 1982;79:4714-7 pubmed
    ..which is homologous to feline sarcoma virus, segregates concordantly with human chromosome 15, and the human c-myb gene, which is homologous to avian myeloblastosis virus onc genes, segregates concordantly with human chromosome 6, ..
  62. Volpe G, Walton D, Del Pozzo W, Garcia P, Dassé E, O Neill L, et al. C/EBPα and MYB regulate FLT3 expression in AML. Leukemia. 2013;27:1487-96 pubmed publisher
    ..These elements permit in vivo binding of several AML-related transcription factors, including the proto-oncogene MYB and the CCAAT/enhancer binding protein C/EBPα, which are recruited to the FLT3 promoter and intronic module, ..
  63. Majello B, Kenyon L, Dalla Favera R. Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus. Proc Natl Acad Sci U S A. 1986;83:9636-40 pubmed
    We have isolated cDNA clones of the human c-myb mRNA that contain approximately 3.4 kilobases of the approximately 3.8-kilobase mRNA sequence...