MYB

Summary

Gene Symbol: MYB
Description: v-myb avian myeloblastosis viral oncogene homolog
Alias: Cmyb, c-myb, c-myb_CDS, efg, c-myb protein (140 AA), c-myb10A_CDS, c-myb13A_CDS, c-myb14A_CDS, c-myb8B_CDS, proto-oncogene c-Myb, transcriptional activator Myb
Species: human

Top Publications

  1. pmc Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK
    Chie Kanei-Ishii
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, Tsukuba, Ibaraki 305 0074, Japan
    Genes Dev 18:816-29. 2004
  2. pmc Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck
    Marta Persson
    Department of Pathology, Lundberg Laboratory for Cancer Research, the Sahlgrenska Academy at University of Gothenburg, SE 413 45 Gothenburg, Sweden
    Proc Natl Acad Sci U S A 106:18740-4. 2009
  3. doi TGFβ-induced c-Myb affects the expression of EMT-associated genes and promotes invasion of ER+ breast cancer cells
    Vincenzo Cesi
    ENEA Research Center Casaccia, Laboratory of Radiation Biology and Biomedicine, Casaccia, Rome, Italy
    Cell Cycle 10:4149-61. 2011
  4. pmc MYB suppresses differentiation and apoptosis of human breast cancer cells
    Yvette Drabsch
    University of Queensland Diamantina Institute, University of Queensland, Ipswich Road, Brisbane, Queensland, 4102, Australia
    Breast Cancer Res 12:R55. 2010
  5. pmc Expression of Slug is regulated by c-Myb and is required for invasion and bone marrow homing of cancer cells of different origin
    Barbara Tanno
    Italian National Agency for New Technologies, Energy and Sustainable Economic Development ENEA, Research Center Casaccia, Laboratory of Radiation Biology and Biomedicine, 00123 Rome, Italy
    J Biol Chem 285:29434-45. 2010
  6. pmc c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis
    Shenghao Jin
    Division of Hematology Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 120:593-606. 2010
  7. pmc c-Myb contributes to G2/M cell cycle transition in human hematopoietic cells by direct regulation of cyclin B1 expression
    Yuji Nakata
    Division of Hematology Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Cell Biol 27:2048-58. 2007
  8. pmc Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53
    Chad Deisenroth
    University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, School of Medicine, Chapel Hill, NC, USA
    Mol Cell Biol 30:3981-93. 2010
  9. doi c-myb mediates inflammatory reaction against oxidative stress in human breast cancer cell line, MCF-7
    Govinda Bhattarai
    Department of Oral Biochemistry, Institute of Oral Bio Science and BK21 Program, School of Dentistry, Chonbuk National University, Joenju, Korea
    Cell Biochem Funct 29:686-93. 2011
  10. pmc Transcription factor c-Myb promotes the invasion of hepatocellular carcinoma cells via increasing osteopontin expression
    Rong xin Chen
    Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China
    J Exp Clin Cancer Res 29:172. 2010

Detail Information

Publications193 found, 100 shown here

  1. pmc Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK
    Chie Kanei-Ishii
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, Tsukuba, Ibaraki 305 0074, Japan
    Genes Dev 18:816-29. 2004
    The c-myb proto-oncogene product (c-Myb) regulates both the proliferation and apoptosis of hematopoietic cells by inducing the transcription of a group of target genes...
  2. pmc Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck
    Marta Persson
    Department of Pathology, Lundberg Laboratory for Cancer Research, the Sahlgrenska Academy at University of Gothenburg, SE 413 45 Gothenburg, Sweden
    Proc Natl Acad Sci U S A 106:18740-4. 2009
    The transcription factor gene MYB was identified recently as an oncogene that is rearranged/duplicated in some human leukemias. Here we describe a new mechanism of activation of MYB in human cancer involving gene fusion...
  3. doi TGFβ-induced c-Myb affects the expression of EMT-associated genes and promotes invasion of ER+ breast cancer cells
    Vincenzo Cesi
    ENEA Research Center Casaccia, Laboratory of Radiation Biology and Biomedicine, Casaccia, Rome, Italy
    Cell Cycle 10:4149-61. 2011
    ..We show here that the expression of c-Myb increases in TGFβ-treated ER (+) breast cancer cells by protein stabilization, transcription activation and ..
  4. pmc MYB suppresses differentiation and apoptosis of human breast cancer cells
    Yvette Drabsch
    University of Queensland Diamantina Institute, University of Queensland, Ipswich Road, Brisbane, Queensland, 4102, Australia
    Breast Cancer Res 12:R55. 2010
    b>MYB is highly expressed in estrogen receptor positive (ER + ve) breast tumours and tumour cell lines...
  5. pmc Expression of Slug is regulated by c-Myb and is required for invasion and bone marrow homing of cancer cells of different origin
    Barbara Tanno
    Italian National Agency for New Technologies, Energy and Sustainable Economic Development ENEA, Research Center Casaccia, Laboratory of Radiation Biology and Biomedicine, 00123 Rome, Italy
    J Biol Chem 285:29434-45. 2010
    ..myeloid leukemia-blast crisis, and in neuroblastoma cells, expression of Slug is transcriptionally regulated by c-Myb via Myb binding sites in the 5'-flanking region and in the first intron of the slug gene...
  6. pmc c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis
    Shenghao Jin
    Division of Hematology Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 120:593-606. 2010
    ..Recent data suggest that the MYB proto-oncogene, which is an important regulator of hematopoietic cell development, has a role in leukemogenesis ..
  7. pmc c-Myb contributes to G2/M cell cycle transition in human hematopoietic cells by direct regulation of cyclin B1 expression
    Yuji Nakata
    Division of Hematology Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Cell Biol 27:2048-58. 2007
    b>Myb family proteins are ubiquitously expressed transcription factors...
  8. pmc Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53
    Chad Deisenroth
    University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, School of Medicine, Chapel Hill, NC, USA
    Mol Cell Biol 30:3981-93. 2010
    ..In addition, Hep27 is regulated at the transcriptional level by the proto-oncogene c-Myb and is required for c-Myb-induced p53 stabilization...
  9. doi c-myb mediates inflammatory reaction against oxidative stress in human breast cancer cell line, MCF-7
    Govinda Bhattarai
    Department of Oral Biochemistry, Institute of Oral Bio Science and BK21 Program, School of Dentistry, Chonbuk National University, Joenju, Korea
    Cell Biochem Funct 29:686-93. 2011
    ..This study examined the contribution of proto-oncogene c-myb to inflammation in MCF-7 breast cancer cells...
  10. pmc Transcription factor c-Myb promotes the invasion of hepatocellular carcinoma cells via increasing osteopontin expression
    Rong xin Chen
    Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China
    J Exp Clin Cancer Res 29:172. 2010
    ..Osteopontin (OPN) is a phosphoprotein that mediates hepatocellular carcinoma (HCC) progression and metastasis. However, the mechanism of OPN up-regulation in HCC metastasis remains to be clarified...
  11. ncbi Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development
    Hiroshi Sakamoto
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Blood 108:896-903. 2006
    ..c-Myb is a transcription factor that is essential for the development of definitive hematopoiesis...
  12. pmc Loss of androgen receptor in aging and oxidative stress through Myb protooncoprotein-regulated reciprocal chromatin dynamics of p53 and poly(ADP-ribose) polymerase PARP-1
    Liheng Shi
    Department of Molecular Medicine Institute of Biotechnology, The University of Texas Health Science Center, San Antonio, Texas 78245, USA
    J Biol Chem 283:36474-85. 2008
    ..The coregulator switch is mediated by B-Myb and c-Myb, which bind to the ADF element and physically associate with PARP-1 and the tumor suppressor p53...
  13. doi c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression
    Elisa Bianchi
    Department of Biomedical Sciences, Biological Chemistry Section, University of Modena and Reggio Emilia, Modena, Italy
    Blood 116:e99-110. 2010
    The c-myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation...
  14. ncbi Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation
    Chie Kanei-Ishii
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    J Biol Chem 279:44582-9. 2004
    Recently we have shown that the c-myb proto-oncogene product (c-Myb) is degraded in response to Wnt-1 signaling via the pathway involving TAK1 (transforming growth factor-beta-activated kinase), HIPK2 (homeodomain-interacting protein ..
  15. pmc Identification and regulation of c-Myb target genes in MCF-7 cells
    Anita M Quintana
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
    BMC Cancer 11:30. 2011
    The c-Myb transcription factor regulates differentiation and proliferation in hematopoietic cells, stem cells and epithelial cells...
  16. ncbi Identification of alternatively spliced transcripts for human c-myb: molecular cloning and sequence analysis of human c-myb exon 9A sequences
    P Dasgupta
    Wistar Institute, Philadelphia, Pennsylvania 19104
    Oncogene 4:1419-23. 1989
    The murine c-myb gene has been recently shown to code for two protein products of 75kd and 89kd...
  17. ncbi c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation
    Mark L Sandberg
    Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Dev Cell 8:153-66. 2005
    ..a mouse line that harbors a point mutation in the transactivation (TA) domain of the transcription factor c-Myb (M303V), which reduces c-Myb-dependent TA by disrupting its interaction with the transcriptional coactivator p300...
  18. pmc c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis
    Lucia Knopfova
    Department of Experimental Biology, Faculty of Science, Masaryk University, and International Clinical Research Center, CBCE, St Anne s University Hospital, Brno, Czech Republic
    Mol Cancer 11:15. 2012
    The c-Myb transcription factor is essential for the maintenance of stem-progenitor cells in bone marrow, colon epithelia, and neurogenic niches. c-Myb malfunction contributes to several types of malignancies including breast cancer...
  19. pmc Sequence variants in three loci influence monocyte counts and erythrocyte volume
    Manuel A R Ferreira
    Queensland Institute of Medical Research QIMR, Brisbane, QLD 4029, Australia
    Am J Hum Genet 85:745-9. 2009
    ..001, 9.9x10(-5), and 7x10(-5), respectively). The identification of these QTL provides new opportunities for furthering our understanding of the mechanisms regulating hemopoietic cell fate...
  20. pmc DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease
    Guillaume Lettre
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 105:11869-74. 2008
    ..Common single nucleotide polymorphisms (SNPs) at the BCL11A and HBS1L-MYB loci have been implicated previously in HbF level variation in nonanemic European populations...
  21. pmc MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13
    Vijay G Sankaran
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 108:1519-24. 2011
    ..Moreover, we show that a direct target of these microRNAs, MYB, plays an important role in silencing the fetal and embryonic hemoglobin genes...
  22. doi c-Myb is an evolutionary conserved miR-150 target and miR-150/c-Myb interaction is important for embryonic development
    You Chin Lin
    Genomics Research Center, Academia Sinica Taipei, Taiwan
    Mol Biol Evol 25:2189-98. 2008
    Human c-Myb proto-oncogene is highly expressed in hematopoietic progenitors as well as leukemia and certain solid tumor. However, the regulatory mechanisms of its expression and biological functions remain largely unclear...
  23. pmc The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells
    Huiwu Zhao
    Division of Hematology Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Blood 113:505-16. 2009
    The c-myb proto-oncogene encodes an obligate hematopoietic cell transcription factor important for lineage commitment, proliferation, and differentiation...
  24. ncbi Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
    Idoya Lahortiga
    Human Genome Laboratory, Department of Molecular and Developmental Genetics, Vlaams Instituut voor Biotechnologie VIB, Leuven, Belgium
    Nat Genet 39:593-5. 2007
    We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines...
  25. doi Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
    Daniel F Gudbjartsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 41:342-7. 2009
    ..SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4...
  26. pmc Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells
    Yvette Drabsch
    University of Queensland Diamantina Institute for Cancer, Immunology, and Metabolic Medicine, Brisbane, Queensland 4102, Australia
    Proc Natl Acad Sci U S A 104:13762-7. 2007
    b>MYB (the human ortholog of c-myb) is expressed in a high proportion of human breast tumors, and that expression correlates strongly with estrogen receptor (ER) positivity...
  27. ncbi Increased affinity of c-Myb for CREB-binding protein (CBP) after CBP-induced acetylation
    Y Sano
    Laborartory of Molecular Genetics, RIKEN Tsukuba Institute and the CREST Core Research for Evolutional Science and Technology Research Project of JST Japan Science and Technology Corporation, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    J Biol Chem 276:3674-82. 2001
    The c-myb proto-oncogene product (c-Myb) is a sequence-specific DNA-binding protein that functions as a transcriptional activator...
  28. ncbi The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children
    Emmanuelle Clappier
    Genome Rearrangements and Cancer Group, Institut National de la Santé et de la Recherche Médicale U728 and Institut Universitaire d Hématologie, Paris 7 University, Hopital Saint Louis, Paris, France
    Blood 110:1251-61. 2007
    The C-Myb transcription factor is essential for hematopoiesis, including in the T-cell lineage...
  29. ncbi Estrogen and MYB in breast cancer: potential for new therapies
    Thomas J Gonda
    Professorial Research Fellow, Deputy Director and Head Cancer Biology Program, University of Queensland Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
    Expert Opin Biol Ther 8:713-7. 2008
    b>MYB is highly expressed in almost all estrogen receptor (ER)-positive breast tumours and is a direct target of estrogen/ER signalling...
  30. doi FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci
    A H Alm-Kristiansen
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    Oncogene 27:4644-56. 2008
    The c-Myb oncoprotein is a DNA-binding transcription factor with a key role in early stages of hematopoiesis...
  31. ncbi c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300
    A Tomita
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Oncogene 19:444-51. 2000
    Transcription factor c-Myb plays important roles in cell survival and differentiation in immature hematopoietic cells...
  32. pmc Alternative RNA splicing produces multiple forms of c-Myb with unique transcriptional activities
    JOHN P O'ROURKE
    Department of Molecular Genetics and Microbiology, MSC08 4660, 1 University of New Mexico, Albuquerque, NM 87131 0001, USA
    Mol Cell Biol 28:2091-101. 2008
    The c-Myb transcription factor regulates the proliferation and differentiation of hematopoietic cells, and activated alleles of c-myb induce leukemias and lymphomas in animals...
  33. ncbi Stress-induced inactivation of the c-Myb transcription factor through conjugation of SUMO-2/3 proteins
    Marek Sramko
    Center of Molecular Medicine, Cancer Research Institute, Slovak Academy of Sciences, 833 91 Bratislava, Slovakia
    J Biol Chem 281:40065-75. 2006
    ..and SUMOylation, play an important role in regulation of the stability and the transcriptional activity of c-Myb. Conjugation of small ubiquitin-like modifier type 1 (SUMO-1) to lysines in the negative regulatory domain strongly ..
  34. doi Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb
    K Kitagawa
    Department of Biochemistry 1, Hamamatsu University School of Medicine, Higashi ku, Hamamatsu, Shizuoka, Japan
    Oncogene 28:2393-405. 2009
    Expression of oncoprotein c-Myb oscillates during hematopoiesis and hematological malignancies...
  35. pmc Human T-cell lymphotropic virus type 1 Tax represses c-Myb-dependent transcription through activation of the NF-kappaB pathway and modulation of coactivator usage
    C Nicot
    Section of Animal Models and Retroviral Vaccines, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Mol Cell Biol 21:7391-402. 2001
    The proto-oncogene c-myb is essential for a controlled balance between cell growth and differentiation...
  36. pmc Genome annotation of a 1.5 Mb region of human chromosome 6q23 encompassing a quantitative trait locus for fetal hemoglobin expression in adults
    James Close
    Department of Haematological Medicine, GKT School of Medicine, London, SE5 9PJ, UK
    BMC Genomics 5:33. 2004
    ....
  37. pmc Dramatic repositioning of c-Myb to different promoters during the cell cycle observed by combining cell sorting with chromatin immunoprecipitation
    Anita M Quintana
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America
    PLoS ONE 6:e17362. 2011
    The c-Myb transcription factor is a critical regulator of proliferation and stem cell differentiation, and mutated alleles of c-Myb are oncogenic, but little is known about changes in c-Myb activity during the cell cycle...
  38. ncbi Alternative splicing of the human c-myb gene
    E H Westin
    Department of Medicine, Medical College of Virginia, Virginia Commonwealth University
    Oncogene 5:1117-24. 1990
    Two cDNA clones of the human c-myb gene have been isolated from a CCRF-CEM leukemia cell cDNA library and sequenced in their entirety...
  39. doi A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability
    T Saether
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    Oncogene 30:212-22. 2011
    c-Myb is an essential hematopoietic transcription factor that controls proliferation and differentiation of progenitors during blood cell development...
  40. pmc Positive and negative regulation of c-Myb by cyclin D1, cyclin-dependent kinases, and p27 Kip1
    Wanli Lei
    Department of Molecular Genetics and Microbiology, University of New Mexico, HSC, Albuquerque, NM 87131 0001, USA
    Blood 105:3855-61. 2005
    The c-Myb transcription factor controls differentiation and proliferation in hematopoietic and other cell types and has latent transforming activity, but little is known about its regulation during the cell cycle...
  41. ncbi Activation of c-MYC and c-MYB proto-oncogenes is associated with decreased apoptosis in tumor colon progression
    C Greco
    Clinical Pathology Service, Regina Elena Cancer Institute, Rome, Italy
    Anticancer Res 21:3185-92. 2001
    ..between frequency of spontaneous apoptosis during transition adenoma-to-carcinoma of the colorectal tract and the incidence of activation of c-myc and c-myb proto-oncogenes, involved both in colon tumorigenesis and apoptosis.
  42. doi Involvement of MyoD and c-myb in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene
    Wei Jin
    Department of Breast Surgery, Breast Cancer Institute, Cancer Hospital Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road Road, Shanghai, 200032, People s Republic of China
    Breast Cancer Res Treat 125:699-713. 2011
    ..that MyoD expression and BRCA1 expression is correlated in sporadic breast tumors, overexpression of MyoD and c-myb stimulates BRCA1 expression, knockdown of MyoD and c-myb attenuates BRCA1 expression and attenuates the ability of ..
  43. ncbi Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner
    Øyvind Dahle
    Department of Biochemistry, University of Oslo, Norway
    Eur J Biochem 270:1338-48. 2003
    The transcription factor v-Myb is a potent inducer of myeloid leukemias, and its cellular homologue c-Myb plays a crucial role in the regulation of hematopoiesis. Recently, Bies and coworkers (Bies, J., Markus, J. & Wolff, L...
  44. doi HIPK1 interacts with c-Myb and modulates its activity through phosphorylation
    Vilborg Matre
    Department of Molecular Biosciences, University of Oslo, Norway
    Biochem Biophys Res Commun 388:150-4. 2009
    The transcription factor v-Myb is a potent inducer of myeloid leukaemias, and its cellular homologue c-Myb plays a crucial role in the regulation of haematopoiesis...
  45. ncbi Expression of insulin-like growth factor-binding protein 5 in neuroblastoma cells is regulated at the transcriptional level by c-Myb and B-Myb via direct and indirect mechanisms
    Barbara Tanno
    Ente Nuove Tecnologie Energia Ambiente ENEA, Section of Toxicology and Biomedical Sciences, Via Anguillarese 301, 00060 S Maria di Galeria, Rome, Italy
    J Biol Chem 277:23172-80. 2002
    ..Upon conditional expression of c-Myb in a NB cell line, we detected up-regulation of IGF1, IGF1 receptor, and insulin-like growth factor-binding protein ..
  46. pmc c-Myb is required for pro-B cell differentiation
    Shawn P Fahl
    Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Immunol 183:5582-92. 2009
    The c-Myb transcription factor is required for normal adult hematopoiesis. However, the embryonic lethality of Myb-null mutations has been an impediment to identifying roles for c-Myb during lymphocyte development...
  47. ncbi Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers
    Honor Hugo
    Peter MacCallum Cancer Center, East Melbourne and Department of Pathology, The University of Melbourne, Australia
    Genes Chromosomes Cancer 45:1143-54. 2006
    Although MYB overexpression in colorectal cancer (CRC) is known to be a prognostic indicator for poor survival, the basis for this overexpression is unclear...
  48. ncbi Covalent attachment of the SUMO-1 protein to the negative regulatory domain of the c-Myb transcription factor modifies its stability and transactivation capacity
    Juraj Bies
    Department of Molecular Virology, Cancer Research Institute, Slovak Academy of Sciences, Vlarska 7, 833 91 Bratislava, Slovakia
    J Biol Chem 277:8999-9009. 2002
    The transcription factor c-Myb is subject to several types of post-translational modifications, including phosphorylation, acetylation, and ubiquitination...
  49. ncbi Studies of the human c-myb gene and its product in human acute leukemias
    D J Slamon
    Science 233:347-51. 1986
    The myb gene is the transforming oncogene of the avian myeloblastosis virus (AMV); its normal cellular homolog, c-myb, is conserved across a broad span of evolution...
  50. ncbi The chromatin remodeling factor Mi-2alpha acts as a novel co-activator for human c-Myb
    Thomas Saether
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    J Biol Chem 282:13994-4005. 2007
    The c-Myb protein belongs to a group of early hematopoietic transcription factors that are important for progenitor generation and proliferation...
  51. ncbi Pim-1 kinase and p100 cooperate to enhance c-Myb activity
    J D Leverson
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208 3500, USA
    Mol Cell 2:417-25. 1998
    ..screen, we found that Pim-1 protein binds to p100, a transcriptional coactivator that interacts with the c-Myb transcription factor...
  52. ncbi c-Myb down-regulation is associated with human colon cell differentiation, apoptosis, and decreased Bcl-2 expression
    M A Thompson
    Ludwig Institute for Cancer Research, P O Royal Melbourne Hospital, Victoria, Australia
    Cancer Res 58:5168-75. 1998
    c-myb is expressed in human and murine colonic mucosa and elevated expression occurs in premalignant adenomatous polyps and carcinomas...
  53. pmc Role of c-Myb during prolactin-induced signal transducer and activator of transcription 5a signaling in breast cancer cells
    Feng Fang
    Department of Pathology, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    Endocrinology 150:1597-606. 2009
    ..These analyses revealed a PRL-inducible association of Stat5a with the transcription factor and protooncogene c-Myb. Confirmatory co-immunoprecipitation studies using lysates from both T47D and MCF7 breast cancer cells revealed a ..
  54. ncbi The myb gene family in cell growth, differentiation and apoptosis
    I H Oh
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Oncogene 18:3017-33. 1999
    The myb gene family consists of three members, named A, B and c-myb which encode nuclear proteins that function as transcriptional transactivators...
  55. ncbi The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb
    A B Dash
    Northwestern University, Department of Biochemistry, Molecular Biology and Cell Biology, Evanston, Illinois 60208 3500, USA
    Genes Dev 10:1858-69. 1996
    The c-Myb transcription factor is a proto-oncoprotein whose latent transforming activity can be unmasked by truncation of either terminus...
  56. ncbi Enhanced proliferative potential of hematopoietic cells expressing degradation-resistant c-Myb mutants
    Francesca Corradini
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 280:30254-62. 2005
    The c-myb gene encodes a transcription factor required for proliferation, differentiation, and survival of hematopoietic cells...
  57. pmc Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus
    B Majello
    Proc Natl Acad Sci U S A 83:9636-40. 1986
    We have isolated cDNA clones of the human c-myb mRNA that contain approximately 3.4 kilobases of the approximately 3.8-kilobase mRNA sequence...
  58. ncbi Effect of ecteinascidin-743 on the interaction between DNA binding proteins and DNA
    M Bonfanti
    Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Anticancer Drug Des 14:179-86. 1999
    ..We have selected three types of factors: (i) oncogene products such as MYC, c-MYB and Maf; (ii) transcriptional activators regulated during the cell cycle as E2F and SRF; and (iii) general ..
  59. ncbi [Effect of antisense oligonucleotides on myo-intimal hyperplasia in a model of abdominal aortic injury in the rat]
    E Chemla
    , Paris
    Arch Mal Coeur Vaiss 88:381-9. 1995
    ..The proto-oncogene c-myb is a gene with an immediate response which has been implicated in the proliferation and alteration of the phenotype ..
  60. pmc Protein truncation is required for the activation of the c-myb proto-oncogene
    F A Grasser
    Institut fur Medizinische Mikrobiologie und Hygiene, Abteilung Virologie, Universitatskliniken des Saarlandes, Homburg, Germany
    Mol Cell Biol 11:3987-96. 1991
    The protein product of the v-myb oncogene of avian myeloblastosis virus, v-Myb, differs from its normal cellular counterpart, c-Myb, by (i) expression under the control of a strong viral long terminal repeat, (ii) truncation of both its ..
  61. ncbi A spontaneous internal deletion of the c-myb protooncogene enhances transcriptional activation in bovine T lymphoma cells
    N Ishiguro
    Department of Veterinary Public Health, Obihiro University of Agriculture and Veterinary Medicine, Japan
    J Biol Chem 269:26822-9. 1994
    ..have been established from bovine lymphosarcomas, were examined for expression and molecular function of bovine c-myb genes. BTL-PC3 expressed 4.0- and 3.6-kilobase c-myb transcripts, and BLT2 and Pr2181 expressed a 3...
  62. ncbi p38MAPK delta controls c-Myb degradation in response to stress
    Elisabetta Pani
    Institute of Molecular Cancer Research, University of Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Blood Cells Mol Dis 40:388-94. 2008
    The c-myb gene is the progenitor of the v-myb oncogene, which causes avian myelomonocytic leukemia...
  63. ncbi Expression of the c-myb proto-oncogene in bovine vascular smooth muscle cells
    K E Brown
    Department of Biochemistry, Boston University School of Medicine, Massachusetts 02118
    J Biol Chem 267:4625-30. 1992
    Previously we have shown that bovine vascular smooth muscle cells (SMCs) express c-myb mRNA (Reilly, C. F., Kindy, M. S., Brown, K. E., Rosenberg, R. D., and Sonenshein, G. E. (1989) J. Biol. Chem. 264, 6990-6995)...
  64. ncbi Melanocyte fate in neural crest is triggered by Myb proteins through activation of c-kit
    V Karafiat
    Department of Molecular Virology, Institute of Molecular Genetics, AS CR v v i, Videnska 1083, Prague 4, 14220, Czech Republic
    Cell Mol Life Sci 64:2975-84. 2007
    The c-myb proto-oncogene and its oncogenic derivative v-mybAMV encode transcriptional regulators engaged in the commitment of hematopoietic cells...
  65. ncbi v-Myb suppresses phorbol ester- and modifies retinoic acid-induced differentiation of human promonocytic U937 cells
    L Knopfova
    Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
    Neoplasma 55:286-93. 2008
    The c-myb protooncogene as well as its transforming derivate, the v-myb oncogene code for transcription factors...
  66. ncbi v-Myb represses the transcription of Ets-2
    D M Wang
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Oncogene 26:1238-44. 2007
    The v-Myb oncogene causes monoblastic leukemia and transforms only myelomonocytic cells in culture. The v-Myb protein is nuclear and binds to specific DNA sequences...
  67. pmc Conifer R2R3-MYB transcription factors: sequence analyses and gene expression in wood-forming tissues of white spruce (Picea glauca)
    Frank Bedon
    Centre d Etude de la Forêt, Universite Laval, Pavillon Charles Eugène Marchand, Sainte Foy G1K7P4, Quebec, Canada
    BMC Plant Biol 7:17. 2007
    Several members of the R2R3-MYB family of transcription factors act as regulators of lignin and phenylpropanoid metabolism during wood formation in angiosperm and gymnosperm plants...
  68. pmc Modulation of c-Myb-induced transcription activation by a phosphorylation site near the negative regulatory domain
    N Aziz
    Department of Pharmacology, University of Virginia, Charlottesville 22908, USA
    Proc Natl Acad Sci U S A 92:6429-33. 1995
    The c-myb protooncogene encodes a highly conserved transcription factor that functions as both an activator and a repressor of transcription...
  69. pmc A-myb is expressed in bovine vascular smooth muscle cells during the late G1-to-S phase transition and cooperates with c-myc to mediate progression to S phase
    D J Marhamati
    Department of Biochemistry, Boston University School of Medicine, Massachusetts 02118, USA
    Mol Cell Biol 17:2448-57. 1997
    The Myb family of transcription factors is defined by homology within the DNA binding domain and includes c-Myb, A-Myb, and B-Myb. The protein products of the myb genes all bind the Myb-binding site (MBS) [YG(A/G)C(A/C/G)GTT(G/A)]...
  70. ncbi B-Myb repressor function is regulated by cyclin A phosphorylation and sequences within the C-terminal domain
    Constantinos Petrovas
    Department of Biochemistry, Boston University Medical School, MA 02118 2394, USA
    Oncogene 22:2011-20. 2003
    B-Myb is a widely expressed member of the myb oncogene family that has been shown to act as either an activator or repressor of gene transcription in a cell-type-specific fashion...
  71. ncbi Overexpression of v-myb oncogene or c-myb proto-oncogene in insect cells: characterization of newly induced nucleolus-like structures accumulating Myb protein
    Jitka Stokrova
    Department of Biopolymers Micromorphology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Flemingovo nam 2, 166 37 Praha 6, Czech Republic
    Int J Mol Med 9:547-54. 2002
    The oncoprotein v-Myb induces myeloid leukemia and its cellular counterpart c-Myb is involved in the regulation of hematopoiesis. Although intensively studied, their precise subcellular localization is not known...
  72. ncbi Overexpression of c-myb in leukaemic and non-leukaemic variants of cutaneous T-cell lymphoma
    N Poenitz
    Department of Dermatology, Venereology and Allergology, University Medical Centre Mannheim, Ruprecht Karl University of Heidelberg, Mannheim, Germany
    Dermatology 211:84-92. 2005
    The c-myb oncogene is a transcription factor that regulates proliferation, differentiation and apoptosis of haematopoietic cells and activated T cells by binding to promoter sequences of such genes as c-myc or bcl-2 that are expressed in ..
  73. ncbi Independent regulation of c-myc, B-myb, and c-myb gene expression by inducers and inhibitors of proliferation in human B lymphocytes
    J Golay
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Immunol 149:300-8. 1992
    ..The c-myb proto-oncogene, the structurally related B-myb gene, and c-myc probably code for transcription factors, have been ..
  74. pmc Extension of the DNA binding consensus of the chicken c-Myb and v-Myb proteins
    K Weston
    Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    Nucleic Acids Res 20:3043-9. 1992
    The chicken c-myb gene and the v-myb oncogene transduced by avian myeloblastosis virus (AMV) encode DNA binding transcription activators...
  75. pmc Deregulated c-myb disrupts interleukin-6- or leukemia inhibitory factor-induced myeloid differentiation prior to c-myc: role in leukemogenesis
    M Selvakumaran
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia 19104 6059
    Mol Cell Biol 12:2493-500. 1992
    The c-myb proto-oncogene is abundantly expressed in tissues of hematopoietic origin, and changes in endogenous c-myb genes have been implicated in both human and murine hematopoietic tumors...
  76. pmc Identification of conserved gene structures and carboxy-terminal motifs in the Myb gene family of Arabidopsis and Oryza sativa L. ssp. indica
    Cizhong Jiang
    Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA
    Genome Biol 5:R46. 2004
    b>Myb proteins contain a conserved DNA-binding domain composed of one to four repeat motifs (referred to as R0R1R2R3); each repeat is approximately 50 amino acids in length, with regularly spaced tryptophan residues...
  77. pmc Recently duplicated maize R2R3 Myb genes provide evidence for distinct mechanisms of evolutionary divergence after duplication
    Anusha P Dias
    Plant Genetics Research and Plant Science Units, United States Department of Agriculture Agricultural Research Service, University of Missouri, Columbia, Missouri 65211, USA
    Plant Physiol 131:610-20. 2003
    R2R3 Myb genes are widely distributed in the higher plants and comprise one of the largest known families of regulatory proteins...
  78. ncbi A subgroup of MYB transcription factor genes undergoes highly conserved alternative splicing in Arabidopsis and rice
    Jigang Li
    Peking Yale Joint Center for Plant Molecular Genetics and Agro Biotechnology, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, PR China
    J Exp Bot 57:1263-73. 2006
    b>MYB transcription factor genes play important roles in many developmental processes and in various defence responses of plants. Two Arabidopsis R2R3-type MYB genes, AtMYB59 and AtMYB48, were found to undergo similar alternative splicing...
  79. ncbi Regulation of c-myb oncogene expression in immature and mature murine T cells
    J D Mountz
    Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham
    Mol Immunol 30:787-95. 1993
    The c-myb oncogene encodes a nuclear binding protein which may play a major role in differentiation during early T cell development...
  80. pmc Protein truncation is not required for c-myb proto-oncogene activity in neuroretina cells
    C Garrido
    CNRS URA 1160, Institut Pasteur de Lille, France
    J Virol 66:6773-6. 1992
    The v-myb oncogene of avian myeloblastosis virus (AMV) differs from its normal cellular counterpart by a truncation at both its amino and carboxyl termini and by a substitution of 11 amino acid residues...
  81. ncbi c-MYB oncogene-like genes encoding three MYB repeats occur in all major plant lineages
    H Kranz
    Max Planck Institut fur Zuchtungsforschung, Abteilung Biochemie, Koln, Germany
    Plant J 21:231-5. 2000
    Since the identification of the first plant MYB-like protein, the Zea mays factor C1, the number of MYB-related genes described has greatly increased...
  82. ncbi Presence of regulatory sequences within intron 4 of human and murine c-myb genes
    T Seib
    Human Genetics Department, University of Saarland, Homburg, Germany
    Biochim Biophys Acta 1219:285-92. 1994
    The molecular mechanisms that modulate c-myb mRNA transcription in hematopoietic cells appear to involve intron regulatory sequences...
  83. ncbi The c-Myb oncoprotein
    T J Gonda
    Division of Human Immunology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, Australia
    Int J Biochem Cell Biol 30:547-51. 1998
    The c-myb gene is the cellular homologue of the v-myb oncogenes carried by the avian leukaemia viruses AMV and E26...
  84. pmc Comprehensive analysis of single-repeat R3 MYB proteins in epidermal cell patterning and their transcriptional regulation in Arabidopsis
    Shucai Wang
    Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    BMC Plant Biol 8:81. 2008
    Single-repeat R3 MYB transcription factors are critical components of the lateral inhibition machinery that mediates epidermal cell patterning in plants...
  85. ncbi c-Myb immunoreactivity, protein and mRNA levels significantly increase in the aged hippocampus proper in gerbils
    In Koo Hwang
    Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chuncheon, South Korea
    Neurochem Res 32:1091-7. 2007
    b>Myb genes are a family of transcription factors and have been implicated in the control of the proliferation and differentiation of normal and transformed cells. c-Myb is the best characterized member of the myb family...
  86. pmc Mutation of the Drosophila homologue of the Myb protooncogene causes genomic instability
    J Robert Manak
    Department of Pathology, Stanford University School of Medicine, Room L216, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 99:7438-43. 2002
    Vertebrates have three related Myb genes. The c-Myb protooncogene is required for definitive hematopoiesis in mice and when mutated causes leukemias and lymphomas in birds and mammals...
  87. ncbi Transformation by carboxyl-deleted Myb reflects increased transactivating capacity and disruption of a negative regulatory domain
    Y L Hu
    Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, PO Royal Melbourne Hospital, Victoria, Australia
    Oncogene 6:1549-53. 1991
    Carboxyl-truncated forms of the product of the c-myb proto-oncogene (Myb) are encoded by the v-myb oncogene, the rearranged c-myb genes of certain murine cell lines and a transforming recombinant c-myb retrovirus...
  88. ncbi Dissociation between p93B-myb and p75c-myb expression during the proliferation and differentiation of human myeloid cell lines
    M Arsura
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Blood 83:1778-90. 1994
    Direct and indirect evidence strongly indicates that the proto-oncogene c-myb plays an important role in the regulation of both the proliferation and differentiation of hematopoietic cells...
  89. ncbi Effects of c-myb antisense RNA on TGF-beta1 and beta1-I collagen expression in cultured hepatic stellate cells
    Hui Hui Ma
    Department of Infectious Diseases, The 3rd Affiliated Hospital, Sun Yat Sen University, Guangzhou 510630, Guangdong Province, China
    World J Gastroenterol 10:3662-5. 2004
    To investigate the effects of c-myb antisense RNA on cell proliferation and the expression of c-myb, TGF-beta1 and beta1-I collagen in cultured hepatic stellate cells (HSC) from rats.
  90. ncbi Diverse developing mouse lineages exhibit high-level c-Myb expression in immature cells and loss of expression upon differentiation
    K C Ess
    Division of Molecular and Developmental Biology Children s Hospital Research Foundation, University of Cincinnati, Ohio 45229, USA
    Oncogene 18:1103-11. 1999
    The c-myb gene encodes a sequence specific transactivator that is required for fetal hematopoiesis, but its potential role in other tissues is less clear because of the early fetal demise of mice with targeted deletions of the c-myb gene ..
  91. ncbi Inactivation of a c-Myb/estrogen receptor fusion protein in transformed primary cells leads to granulocyte/macrophage differentiation and down regulation of c-kit but not c-myc or cdc2
    A Hogg
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Oncogene 15:2885-98. 1997
    ..protein consisting of the ligand-binding domain of the estrogen receptor and a carboxyl-terminally truncated c-Myb protein (ERMYB)...
  92. ncbi [Effect of c-myb on hCG-induced testosterone secretion in isolated rat Leydig cells]
    Ai Jiao Xiao
    Department of Physiology, Jiangxi Medical College, Nanchang 330006, China
    Sheng Li Xue Bao 56:353-6. 2004
    The present study was carried out to investigate the effect of antisense c-myb oligodeoxynucleotides (ODN) on hCG-induced testosterone secretion in isolated rat Leydig cells...
  93. ncbi Myb-induced transformation
    L Wolff
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892 4255, USA
    Crit Rev Oncog 7:245-60. 1996
    The c-myb protooncogene has been implicated in the development of avian and murine hematopoietic neoplasms of the myeloid and lymphoid lineages...
  94. pmc Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor
    A M Chumakov
    Department of Medicine, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California 90048, USA
    Mol Cell Biol 17:1375-86. 1997
    Chicken NF-M transcription factor, in cooperation with either c-Myb or v-Myb, is active in the combinatorial activation of myeloid-cell-specific genes in heterologous cell types, such as embryonic fibroblasts...
  95. ncbi [Effects of an anti-c-myb antisense oligonucleotide on myo-intimal proliferation. Specificity of action and consequences on vasoreactivity]
    Y Castier
    , Paris
    Arch Mal Coeur Vaiss 89:889-96. 1996
    Several reports have shown that an 18-mere antisense oligonucleotide directed against c-myb (AS 18) inhibits the proliferation of smooth muscle...
  96. pmc RFX2 is a candidate downstream amplifier of A-MYB regulation in mouse spermatogenesis
    Gary C Horvath
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA
    BMC Dev Biol 9:63. 2009
    ..Focusing on meiotic prophase, some tissue-specific transcription factors are known (A-MYB) or suspected (RFX2) to play important roles in modulating gene expression in pachytene spermatocytes...
  97. ncbi Characterization and expression of the Xenopus c-Myb homolog
    L Amaravadi
    Department of Life Sciences, Indiana State University, Terre Haute 47809
    Oncogene 9:971-4. 1994
    The c-Myb protein is a sequence specific DNA-binding transcriptional regulator that is critically involved in the regulation of hematopoietic differentiation...
  98. doi Estrogen prevents sustained COLO-205 human colon cancer cell growth by inducing apoptosis, decreasing c-myb protein, and decreasing transcription of the anti-apoptotic protein bcl-2
    Heather R Wilkins
    Department of Natural Sciences, Assumption College, 500 Salisbury Street, Worcester, MA 01609, USA
    Tumour Biol 31:16-22. 2010
    The proto-oncogene c-myb is overexpressed in human colon cancer cells. c-myb is known to be affected by estrogen in some breast cancers and leukemias...
  99. ncbi Increased c-myb mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma
    J Brabender
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    J Surg Res 99:301-6. 2001
    ..The genetic basis of this process is increasingly well understood, but no studies have examined the role of the transcription factor c-myb in this disease.
  100. ncbi Sequence-specific DNA displaces 6-p-toluidino-2-naphthalenesulfonate bound to a hydrophobic site on the DNA-binding domain of Drosophila c-myb
    A Madan
    Tata Institute of Fundamental Research, Bombay, India
    Biochemistry 33:7120-6. 1994
    The N-terminal DNA-binding domain of c-myb oncoprotein binds to DNA in a sequence-specific manner...
  101. doi The effects of 1,4-benzoquinone on c-Myb and topoisomerase II in K-562 cells
    Roopam Singh
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
    Mutat Res 645:33-8. 2008
    ..BQ has been shown to increase the activity of c-Myb, which is an important transcription factor involved in hematopoiesis, cell proliferation, and cell differentiation...

Research Grants68

  1. ONCOGENIC ACTIVATION OF MYB FAMILY PROTEINS
    Joseph Lipsick; Fiscal Year: 2003
    The Myb gene family was first discovered because the v-Myb oncogene of the avian myeloblastosis virus (AMV) causes a rapidly fatal leukemia in chickens...
  2. Gene Regulation by Myb Proteins
    Joseph Lipsick; Fiscal Year: 2005
    DESCRIPTION (PROVIDE BY APPLICANT): The v-Myb oncogene causes acute monoblastic leukemia in chickens and induces the leukemic transformation of myelomonocytic cells in culture...
  3. REGULATION OF THE V MYB AND C MYB ONCOPROTEINS
    Scott Ness; Fiscal Year: 2004
    The long-term goal of this project is to understand how the c-Myb and v-Myb proteins are regulated, and how they participate in transformation and oncogenesis...
  4. MECHANISM OF TRANSFORMATION BY THE V-MYB ONCOGENE
    Joseph Lipsick; Fiscal Year: 2000
    The v-myb oncogene causes acute monoblastic leukemia in chickens and induces the leukemic transformation of normal myelomonocytic cells in culture...
  5. Regulation of the v-Myb and c-Myb Oncoproteins
    Scott A Ness; Fiscal Year: 2010
    The c-Myb transcription factor is a key regulator of hematopoietic cell differentiation, proliferation and apoptosis and expression of the c-myb gene is essential for normal hematopoiesis...
  6. Regulation of the v-Myb and c-Myb Oncoproteins
    Scott A Ness; Fiscal Year: 2010
    The c-Myb transcription factor is a key regulator of hematopoietic cell differentiation, proliferation and apoptosis and expression of the c-myb gene is essential for normal hematopoiesis...
  7. Myb protein specificity in human hematopoietic cells
    Scott Ness; Fiscal Year: 2009
    This revised application proposes to compare the activities of the wild type and variant versions of c-Myb expressed by normal cells and leukemias, and to determine their relevance to human disease...
  8. TRANSFORMING FUNCTIONS OF THE V-MYB ONCOGENE PRODUCT
    Scott Ness; Fiscal Year: 1999
    The v-myb oncogene is the transforming component of two independently- isolated chicken leukemia viruses...
  9. Biology of the Myb-MuvB Oncoprotein-Tumor Suppressor Protein Complex
    Joseph Lipsick; Fiscal Year: 2009
    ..focuses on a recently discovered and quite unexpected connection between the Rb tumor suppressor pathway and the Myb oncogene family...
  10. Biology of the Myb-MuvB Oncoprotein-Tumor Suppressor Protein Complex
    Joseph Lipsick; Fiscal Year: 2007
    ..focuses on a recently discovered and quite unexpected connection between the Rb tumor suppressor pathway and the Myb oncogene family...
  11. Biology of the Myb-MuvB Oncoprotein-Tumor Suppressor Protein Complex
    JOSEPH STEVEN LIPSICK; Fiscal Year: 2010
    ..focuses on a recently discovered and quite unexpected connection between the Rb tumor suppressor pathway and the Myb oncogene family...
  12. PROTO-ONCOGENES AND CELL CYCLE REGULATION IN DROSOPHILA
    Alisa Katzen; Fiscal Year: 2002
    ..The research described in this proposal addresses the function of the proto-oncogene myb. An understanding of its normal activities should help to illuminate how the activated gene contributes to the ..
  13. PROTO-ONCOGENES AND CELL CYCLE REGULATION IN DROSOPHILA
    Alisa Katzen; Fiscal Year: 2006
    ..This research proposal addresses the function of the proto-oncogene Myb. An understanding of its normal activities should help to illuminate how the activated gene contributes to the ..
  14. MECHANISM OF TRANSFORMATION BY THE V-MBY ONCOGENE
    Joseph Lipsick; Fiscal Year: 1993
    The goal of this project is to understand the mechanism by which the v-myb oncogene of avian myeloblastosis virus (AMV) induces acute myeloid leukemia. This system provides a valuable model for human leukemogenesis for several reasons...
  15. MYB GENE FAMILY AND BREAST CANCER
    E Reddy; Fiscal Year: 2003
    ..The myb gene family currently consists of three members, named A, B and c-myb all of which code for nuclear proteins which ..