Gene Symbol: MVB12A
Description: multivesicular body subunit 12A
Alias: CFBP, FAM125A, multivesicular body subunit 12A, CIN85/CD2AP family binding protein, ESCRT-I complex subunit MVB12A, family with sequence similarity 125, member A
Species: human
Products:     MVB12A

Top Publications

  1. Morita E, Sandrin V, Chung H, Morham S, Gygi S, Rodesch C, et al. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. EMBO J. 2007;26:4215-27 pubmed
    ..These experiments suggest that the ESCRT pathway may be recruited to facilitate analogous membrane fission events during HIV budding, MVB vesicle formation, and the abscission stage of cytokinesis. ..
  2. Morita E, Sandrin V, Alam S, Eckert D, Gygi S, Sundquist W. Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. Cell Host Microbe. 2007;2:41-53 pubmed
    ..We now demonstrate that two related human proteins (MVB12A and MVB12B) constitute the fourth class of metazoan ESCRT-I subunits, despite lacking identifiable sequence ..
  3. Tsunematsu T, Yamauchi E, Shibata H, Maki M, Ohta T, Konishi H. Distinct functions of human MVB12A and MVB12B in the ESCRT-I dependent on their posttranslational modifications. Biochem Biophys Res Commun. 2010;399:232-7 pubmed publisher
    ..In humans, the structurally similar subtypes MVB12A and MVB12B are subunits of ESCRT-I. However, no functional description of these proteins has been described...
  4. Konishi H, Tashiro K, Murata Y, Nabeshi H, Yamauchi E, Taniguchi H. CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP. J Biol Chem. 2006;281:28919-31 pubmed
    ..Here, we focus on characterizing a novel protein, CFBP (CIN85/CD2AP family binding protein), identified in the study...
  5. Oueslati M, Mulet M, Gomila M, Berge O, Hajlaoui M, Lalucat J, et al. New species of pathogenic Pseudomonas isolated from citrus in Tunisia: Proposal of Pseudomonas kairouanensis sp. nov. and Pseudomonas nabeulensis sp. nov. Syst Appl Microbiol. 2019;: pubmed publisher
    ..The type strain is KC12T (=CECT9766 and CFBP 8662)...
  6. Barik S. Dual-Family Peptidylprolyl Isomerases (Immunophilins) of Select Monocellular Organisms. Biomolecules. 2018;8: pubmed publisher
    ..Abbreviated respectively as CFBP and FCBP, the two classes also exhibit distinct organism preference, the CFBP being found in prokaryotes, and the ..
  7. Zoledowska S, Motyka Pomagruk A, Sledz W, Mengoni A, Lojkowska E. High genomic variability in the plant pathogenic bacterium Pectobacterium parmentieri deciphered from de novo assembled complete genomes. BMC Genomics. 2018;19:751 pubmed publisher
    ..The pan-genome study was performed on 15 genomes (12 de novo assembled and three reference strains: P. parmentieri CFBP 8475T, P. parmentieri SCC3193, P. parmentieri WPP163)...
  8. Chaudhary D, Kim J. Acidovorax monticola sp. nov., isolated from soil. Antonie Van Leeuwenhoek. 2018;111:1925-1934 pubmed publisher
    ..analysis, strain K-4-16T belongs to the genus Acidovorax and is closely related to Acidovorax anthurii CFBP 3232T (98.3% sequence identity), Acidovorax konjaci K2T (97...
  9. Lopez M, López Soriano P, Garita Cambronero J, Beltrán C, Taghouti G, Portier P, et al. Xanthomonas prunicola sp. nov., a novel pathogen that affects nectarine (Prunus persica var. nectarina) trees. Int J Syst Evol Microbiol. 2018;68:1857-1866 pubmed publisher
    ..On the basis of these results, the novel strains represent a novel species of the genus Xanthomonas, for which the name Xanthomonas prunicola is proposed. The type strain is CFBP 8353 (=CECT 9404=IVIA 3287.1).

More Information


  1. Meziani S, Oomah B, Zaidi F, Simon Levert A, Bertrand C, Zaidi Yahiaoui R. Antibacterial activity of carob (Ceratonia siliqua L.) extracts against phytopathogenic bacteria Pectobacterium atrosepticum. Microb Pathog. 2015;78:95-102 pubmed publisher
    ..for their in vitro inhibitory ability against the pectinolytic Gram negative Pectobacterium atrosepticum (Pca, CFBP-5384) bacteria, the causal agent of potato soft rot...
  2. Zhang S, Liu X, Yan L, Zhang Q, Zhu J, Huang N, et al. Chemical compositions and antioxidant activities of polysaccharides from the sporophores and cultured products of Armillaria mellea. Molecules. 2015;20:5680-97 pubmed publisher
    ..Four polysaccharides (SP, CMP, CFBP and CFMP) were obtained from wild sporophores and cultured products (including mycelia, fermentation broth and ..
  3. Cenci Goga B, Karama M, Sechi P, Iulietto M, Novelli S, Mattei S. Evolution under different storage conditions of anomalous blue coloration of Mozzarella cheese intentionally contaminated with a pigment-producing strain of Pseudomonas fluorescens. J Dairy Sci. 2014;97:6708-18 pubmed publisher
    ..fluorescens (P. fluorescens ATCC 13525, P.fluorescens CFBP 3150, and P...
  4. Liu F, Ou X, Zhan R. Whole-genome sequence and genome annotation of Xanthomonas citri pv. mangiferaeindicae, causal agent of bacterial black spot on Mangifera indica. Arch Microbiol. 2018;200:835-840 pubmed publisher
    ..citri pv. glycines CFBP 2526, with a completely different host range...
  5. Kuzmanović N, Smalla K, Gronow S, Puławska J. Rhizobium tumorigenes sp. nov., a novel plant tumorigenic bacterium isolated from cane gall tumors on thornless blackberry. Sci Rep. 2018;8:9051 pubmed publisher
    ..nov. is proposed (type strain 1078T?=?DSM 104880T?=?CFBP 8567T). R. tumorigenes is a new plant tumorigenic species carrying the tumor-inducing (Ti) plasmid.
  6. Pesce C, Bolot S, Cunnac S, Portier P, Fischer Le Saux M, Jacques M, et al. High-Quality Draft Genome Sequence of the Xanthomonas translucens pv. cerealis Pathotype Strain CFBP 2541. Genome Announc. 2015;3: pubmed publisher
    ..cerealis is the causal agent of bacterial leaf streak on true grasses. The genome of the pathotype strain CFBP 2541 was sequenced in order to decipher mechanisms that provoke disease and to elucidate the role of transcription ..
  7. Yasuhara Bell J, Alvarez A. Seed-associated subspecies of the genus Clavibacter are clearly distinguishable from Clavibacter michiganensis subsp. michiganensis. Int J Syst Evol Microbiol. 2015;65:811-26 pubmed publisher
    ..nov. for seed-associated strains represented by C55(T) ( = ATCC BAA-2691(T) = CFBP 8216(T)) and ZUM3936(T) ( = ATCC BAA-2690(T) = CFBP 8217(T)), respectively...
  8. Kuzmanović N, Puławska J, Prokić A, Ivanović M, Zlatković N, Gašić K, et al. Draft Genome Sequences of Agrobacterium nepotum Strain 39/7T and Agrobacterium sp. Strain KFB 330. Genome Announc. 2015;3: pubmed publisher
    ..We present here draft genome sequences of nonpathogenic Agrobacterium nepotum strain 39/7(T) (CFBP 7436(T), LMG 26435(T)), isolated from crown gall tumor on Prunus cerasifera, and tumorigenic Agrobacterium sp...
  9. Licciardello G, Bella P, Devescovi G, Strano C, Sarris P, Catara A, et al. Draft Genome Sequence of Pseudomonas mediterranea Strain CFBP 5447T, a Producer of Filmable Medium-Chain-Length Polyhydroxyalkanoates. Genome Announc. 2014;2: pubmed publisher
    Pseudomonas mediterranea strain CFBP 5447(T) is a phytopathogenic bacterium isolated from tomato plants affected by pith necrosis disease...
  10. Indiana A, Briand M, Arlat M, Gagnevin L, Koebnik R, Noël L, et al. Draft Genome Sequence of the Flagellated Xanthomonas fuscans subsp. fuscans Strain CFBP 4884. Genome Announc. 2014;2: pubmed publisher
    We report the draft genome sequence of the flagellated strain CFBP 4884 of Xanthomonas fuscans subsp. fuscans, which was isolated in an outbreak of common bacterial blight of beans along with non-flagellated strains...
  11. Puławska J, Kuzmanović N, Willems A, Pothier J. Pararhizobium polonicum sp. nov. isolated from tumors on stone fruit rootstocks. Syst Appl Microbiol. 2016;39:164-169 pubmed publisher
    ..nov. (type strain F5.1(T)=LMG 28610(T)=CFBP 8359(T)) is proposed.
  12. Kuzmanović N, Puławska J, Smalla K, Nesme X. Agrobacterium rosae sp. nov., isolated from galls on different agricultural crops. Syst Appl Microbiol. 2018;41:191-197 pubmed publisher
    ..nov. is proposed. The type strain of A. rosae is NCPPB 1650T (=DSM 30203T=LMG 230T=CFBP 4470T=IAM 13558T=JCM 20915T).
  13. Chave M, Crozilhac P, Deberdt P, Plouznikoff K, Declerck S. Rhizophagus irregularis MUCL 41833 transitorily reduces tomato bacterial wilt incidence caused by Ralstonia solanacearum under in vitro conditions. Mycorrhiza. 2017;27:719-723 pubmed publisher
    ..Here we report on the effect of R. solanacearum CFBP 6783, classified in phytotype IIB/4NPB, on tomato plantlets grown under strict in vitro culture conditions in the ..
  14. Barik S. On the role, ecology, phylogeny, and structure of dual-family immunophilins. Cell Stress Chaperones. 2017;22:833-845 pubmed publisher
    ..DFIs are of two kinds: CFBP (cyclosporin- and FK506-binding protein) and FCBP (FK506- and cyclosporin-binding protein), found in eukaryotes...
  15. Roux B, Bolot S, Guy E, Denancé N, Lautier M, Jardinaud M, et al. Genomics and transcriptomics of Xanthomonas campestris species challenge the concept of core type III effectome. BMC Genomics. 2015;16:975 pubmed publisher
    ..the genomic coverage of the species by sequencing and annotating the genomes of strains from pathovar incanae (CFBP 1606R and CFBP 2527R), pathovar raphani (CFBP 5828R) and a pathovar formerly named barbareae (CFBP 5825R)...
  16. Pesce C, Bolot S, Berthelot E, Bragard C, Cunnac S, Fischer Le Saux M, et al. Draft Genome Sequence of Xanthomonas translucens pv. graminis Pathotype Strain CFBP 2053. Genome Announc. 2015;3: pubmed publisher
    ..graminis cause bacterial wilt on several forage grasses. A draft genome sequence of pathotype strain CFBP 2053 was generated to facilitate the discovery of new pathogenicity factors and to develop diagnostic tools for the ..
  17. Bolot S, Cerutti A, Carrère S, Arlat M, Fischer Le Saux M, Portier P, et al. Genome Sequences of the Race 1 and Race 4 Xanthomonas campestris pv. campestris Strains CFBP 1869 and CFBP 5817. Genome Announc. 2015;3: pubmed publisher
    ..campestris is the causal agent of black rot on Brassicaceae. The draft genome sequences of strains CFBP 1869 and CFBP 5817 have been determined and are the first ones corresponding to race 1 and race 4 strains, which ..
  18. Mohamad R, Willems A, Le Quéré A, Maynaud G, Pervent M, Bonabaud M, et al. Mesorhizobium delmotii and Mesorhizobium prunaredense are two new species containing rhizobial strains within the symbiovar anthyllidis. Syst Appl Microbiol. 2017;40:135-143 pubmed publisher
    ..nov. (type strain STM4623T=LMG 29640T=CFBP 8436T) and Mesorhizobium prunaredense sp. nov...
  19. Kałużna M, Willems A, Pothier J, Ruinelli M, Sobiczewski P, Puławska J. Pseudomonas cerasi sp. nov. (non Griffin, 1911) isolated from diseased tissue of cherry. Syst Appl Microbiol. 2016;39:370-7 pubmed publisher
    ..cerasi sp. nov. (non Griffin, 1911) is proposed. The type strain of this species is 58(T) (=LMG 28609(T)=CFBP 8305(T)).
  20. Jacques M, Denancé N, Legendre B, Morel E, Briand M, Mississipi S, et al. New Coffee Plant-Infecting Xylella fastidiosa Variants Derived via Homologous Recombination. Appl Environ Microbiol. 2015;82:1556-68 pubmed publisher
    ..One strain, CFBP 8073, isolated from C. canephora imported from Mexico, was assigned to X. fastidiosa subsp. fastidiosa/X...
  21. Kuzmanović N, Puławska J, Prokić A, Ivanović M, Zlatković N, Jones J, et al. Agrobacterium arsenijevicii sp. nov., isolated from crown gall tumors on raspberry and cherry plum. Syst Appl Microbiol. 2015;38:373-8 pubmed publisher
    ..nov. is proposed. The type strain of A. arsenijevicii is KFB 330(T) (= CFBP 8308(T) = LMG 28674(T)).
  22. Essakhi S, Cesbron S, Fischer Le Saux M, Bonneau S, Jacques M, Manceau C. Phylogenetic and Variable-Number Tandem-Repeat Analyses Identify Nonpathogenic Xanthomonas arboricola Lineages Lacking the Canonical Type III Secretion System. Appl Environ Microbiol. 2015;81:5395-410 pubmed publisher
    ..In the nonpathogenic strains CFBP 7640 and CFBP 7653, neither T3SS genes nor any of the analyzed T3E genes were detected...
  23. Ruinelli M, Blom J, Pothier J. Complete Genome Sequence of Pseudomonas viridiflava CFBP 1590, Isolated from Diseased Cherry in France. Genome Announc. 2017;5: pubmed publisher
    ..We report here the first complete genome of a P. viridiflava strain, isolated from diseased tissue of a cherry tree. ..
  24. Kamber T, Pothier J, Pelludat C, Rezzonico F, Duffy B, Smits T. Role of the type VI secretion systems during disease interactions of Erwinia amylovora with its plant host. BMC Genomics. 2017;18:628 pubmed publisher
    ..Three T6SS gene clusters were identified in the genome of E. amylovora CFBP 1430, of which T6SS-1 and T6SS-3 represent complete T6SS machineries, while T6SS-2 is reduced in its gene content...
  25. Wunderley L, Brownhill K, Stefani F, Tabernero L, Woodman P. The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex. J Cell Sci. 2014;127:663-72 pubmed publisher
    ..Here, we show that the incorporation of two MVB12 members, UBAP1 and MVB12A, into ESCRT-I is highly selective with respect to their VPS37 partners...
  26. Boura E, Hurley J. Structural basis for membrane targeting by the MVB12-associated ?-prism domain of the human ESCRT-I MVB12 subunit. Proc Natl Acad Sci U S A. 2012;109:1901-6 pubmed publisher
    ..Here, we find that the MABP domains of the MVB12A and B subunits of ESCRT-I are functional modules that bind in vitro to liposomes containing acidic lipids ..