MUT

Summary

Gene Symbol: MUT
Description: methylmalonyl-CoA mutase
Alias: MCM, methylmalonyl-CoA mutase, mitochondrial, methylmalonyl Coenzyme A mutase, methylmalonyl-CoA isomerase, mutant methylmalonyl CoA mutase, truncated methylmalonyl CoA mutase
Species: human
Products:     MUT

Top Publications

  1. Padovani D, Labunska T, Banerjee R. Energetics of interaction between the G-protein chaperone, MeaB, and B12-dependent methylmalonyl-CoA mutase. J Biol Chem. 2006;281:17838-44 pubmed
    ..These studies provide insights into the energetics of interaction between the radical enzyme methylmalonyl-CoA mutase and MeaB, which are discussed. ..
  2. Hubbard P, Padovani D, Labunska T, Mahlstedt S, Banerjee R, Drennan C. Crystal structure and mutagenesis of the metallochaperone MeaB: insight into the causes of methylmalonic aciduria. J Biol Chem. 2007;282:31308-16 pubmed
  3. Froese D, Kochan G, Muniz J, Wu X, Gileadi C, Ugochukwu E, et al. Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation. J Biol Chem. 2010;285:38204-13 pubmed publisher
    ..Cbl) is essential to the function of two human enzymes, methionine synthase (MS) and methylmalonyl-CoA mutase (MUT)...
  4. Takahashi Íñiguez T, Garcia Arellano H, Trujillo Roldán M, Flores M. Protection and reactivation of human methylmalonyl-CoA mutase by MMAA protein. Biochem Biophys Res Commun. 2011;404:443-7 pubmed publisher
    ..examined the influence of human MMAA protein on the kinetics of the reaction catalyzed by methylmalonyl-CoA mutase (MCM) by testing both purified recombinant proteins in vitro...
  5. Lofgren M, Banerjee R. Loss of allostery and coenzyme B12 delivery by a pathogenic mutation in adenosyltransferase. Biochemistry. 2011;50:5790-8 pubmed publisher
    ..and an escort that delivers the product, adenosylcobalamin (AdoCbl or coenzyme B(12)), to methylmalonyl-CoA mutase (MCM), resulting in holoenzyme formation. Failure to assemble holo-MCM leads to methylmalonic aciduria...
  6. Chen M, Zhuang J, Yang J, Wang D, Yang Q. Atypical hemolytic uremic syndrome induced by CblC subtype of methylmalonic academia: A case report and literature review. Medicine (Baltimore). 2017;96:e8284 pubmed publisher
    Methylmalonic acidemia (MMA) is a common organic acidemia, mainly due to methylmalonyl-CoA mutase (MCM) or its coenzyme cobalamin (VitB12) metabolic disorders...
  7. Liu Y, DING Y, Li X, Wang H, Song J, Ye J, et al. [Acute brainstem encephalitis and myelitis in a girl with isolated methylmalonic aciduria due to MUT gene defect]. Zhongguo Dang Dai Er Ke Za Zhi. 2015;17:1103-6 pubmed
    Methylmalonyl CoA mutase deficiency due to MUT gene defect has been known as the main cause of isolated methylmalonic acidemia in Mainland China...
  8. Pupavac M, Watkins D, Petrella F, Fahiminiya S, Janer A, Cheung W, et al. Inborn Error of Cobalamin Metabolism Associated with the Intracellular Accumulation of Transcobalamin-Bound Cobalamin and Mutations in ZNF143, Which Codes for a Transcriptional Activator. Hum Mutat. 2016;37:976-82 pubmed publisher
    ..AdoCbl) and methylcobalamin (MeCbl) are required for the activity of the enzymes methylmalonyl-CoA mutase (MCM) and methionine synthase (MS)...
  9. Maines E, Morandi G, Gugelmo G, Ion Popa F, Campostrini N, Pasini A, et al. Vitamin B12 Administration by Subcutaneous Catheter Device in a Cobalamin A (cblA) Patient. JIMD Rep. 2017;35:29-31 pubmed publisher
    ..vitamin B12 punctures has been described only in a patient with deficiency of the enzyme methylmalonyl-CoA mutase (MUT). No other experiences are described in the literature...

More Information

Publications142 found, 100 shown here

  1. Baumgartner M, Hörster F, Dionisi Vici C, Haliloglu G, Karall D, Chapman K, et al. Proposed guidelines for the diagnosis and management of methylmalonic and propionic acidemia. Orphanet J Rare Dis. 2014;9:130 pubmed publisher
    ..by accumulation of propionic acid and/or methylmalonic acid due to deficiency of methylmalonyl-CoA mutase (MUT) or propionyl-CoA carboxylase (PCC)...
  2. Almasi T, Guey L, Lukacs C, Csetneki K, Vokó Z, Zelei T. Systematic literature review and meta-analysis on the epidemiology of methylmalonic acidemia (MMA) with a focus on MMA caused by methylmalonyl-CoA mutase (mut) deficiency. Orphanet J Rare Dis. 2019;14:84 pubmed publisher
    ..Isolated MMA is primarily caused by the deficiency of methylmalonyl-CoA mutase (MMA mut; EC 5.4.99.2)...
  3. Laguna J, Cardoso M, Lima J, Reis R, Carvalho A, Saturnino H, et al. Expression of hepatic genes related to energy metabolism during the transition period of Holstein and F1 Holstein-Gir cows. J Dairy Sci. 2017;100:9861-9870 pubmed publisher
    ..of glucose-6-phosphatase (G6PC), cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), methylmalonyl-CoA mutase (MUT), ?-hydroxybutyrate dehydrogenase-2 (BDH2), acetyl-CoA carboxylase (ACC), carnitine palmitoyltransferase-2 (CPT2), ..
  4. Ruppert T, Schumann A, Gröne H, Okun J, Kölker S, Morath M, et al. Molecular and biochemical alterations in tubular epithelial cells of patients with isolated methylmalonic aciduria. Hum Mol Genet. 2015;24:7049-59 pubmed publisher
    ..acids, odd-chain fatty acids and cholesterol caused by complete or partial deficiency of methylmalonyl-CoA mutase (mut(0) and mut(-) subtype respectively) and by defects in the metabolism of its cofactor 5'-deoxyadenosylcobalamin (..
  5. Caterino M, Chandler R, Sloan J, Dorko K, Cusmano Ozog K, Ingenito L, et al. The proteome of methylmalonic acidemia (MMA): the elucidation of altered pathways in patient livers. Mol Biosyst. 2016;12:566-74 pubmed publisher
    ..most commonly caused by the deficient activity of the vitamin B12 dependent enzyme, methylmalonyl-CoA mutase (MUT)...
  6. Lerin C, Goldfine A, Boes T, Liu M, Kasif S, Dreyfuss J, et al. Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism. Mol Metab. 2016;5:926-936 pubmed publisher
    ..49 to 14.28). We studied both cultured cells and mice heterozygous for the BCAA enzyme methylmalonyl-CoA mutase (Mut) and assessed the effects of altered BCAA flux on lipid and glucose homeostasis...
  7. Shafaat M, Alaee M, Rahmanifar A, Setoodeh A, Razzaghy Azar M, Bagherian H, et al. Autozygosity mapping of methylmalonic acidemia associated genes by short tandem repeat markers facilitates the identification of five novel mutations in an Iranian patient cohort. Metab Brain Dis. 2018;33:1689-1697 pubmed publisher
    ..MMA) is a group of inborn errors of metabolism disease which is caused by defect in methylmalonyl-CoA mutase (MCM) enzyme...
  8. Kong X, Shi H, Liu N, Wu Q, Xu X, Zhao Z, et al. Mutation analysis and prenatal diagnosis for three families affected by isolated methylmalonic aciduria. Genet Mol Res. 2014;13:8234-40 pubmed publisher
    ..In the present study, we analyzed MUT gene mutations in 3 Chinese couples with a birth history of isolated MMA...
  9. Keyfi F, Abbaszadegan M, Sankian M, Rolfs A, Orolicki S, Pournasrollah M, et al. Mutation analysis of genes related to methylmalonic acidemia: identification of eight novel mutations. Mol Biol Rep. 2019;46:271-285 pubmed publisher
    ..Using clinical, biochemical, structural and molecular analyses we identified 15 mut MMA, three cblA, one cblB, and four cblC-deficient patients...
  10. Mohamed S, Hamad M, Abu Amero K. Identification of 2 novel homozygous mutations in the methylmalonyl-CoA mutase gene in Saudi patients. Saudi Med J. 2015;36:1110-4 pubmed publisher
    The aim of this report is to analyze the clinical features, and mutations of the methylmalonyl CoA mutase (MUT) gene in 2 patients with methylmalonic aciduria (MMA) attending King Saud University Medical City, Riyadh, Saudi Arabia in ..
  11. Campanello G, Lofgren M, Yokom A, Southworth D, Banerjee R. Switch I-dependent allosteric signaling in a G-protein chaperone-B12 enzyme complex. J Biol Chem. 2017;292:17617-17625 pubmed publisher
    ..chaperone, which gates loading of the active 5'-deoxyadenosylcobalamin cofactor onto methylmalonyl-CoA mutase (MCM) and precludes loading of inactive cofactor forms...
  12. Lin Y, Lin C, Lin W, Zheng Z, Han M, Fu Q. Mild clinical features of isolated methylmalonic acidemia associated with a novel variant in the MMAA gene in two Chinese siblings. BMC Med Genet. 2018;19:114 pubmed publisher
    ..disorder caused by complete or partial deficiency of the enzyme methylmalonyl-CoA mutase (mut0 enzymatic subtype or mut- enzymatic subtype, respectively); a defect in the transport or synthesis of its cofactor, adenosyl-cobalamin (cblA,..
  13. Chandler R, Venditti C. Long-term rescue of a lethal murine model of methylmalonic acidemia using adeno-associated viral gene therapy. Mol Ther. 2010;18:11-6 pubmed publisher
    ..MMA) is an organic acidemia caused by deficient activity of the mitochondrial enzyme methylmalonyl-CoA mutase (MUT). This disorder is associated with lethal metabolic instability and carries a poor prognosis for long-term survival...
  14. Yabuta Y, Kamei Y, Bito T, Arima J, Yoneda K, Sakuraba H, et al. Functional and structural characteristics of methylmalonyl-CoA mutase from Pyrococcus horikoshii. Biosci Biotechnol Biochem. 2015;79:710-7 pubmed publisher
    Methylmalonyl-CoA mutase (MCM) requires 5'-deoxyadenosylcobalamin (AdoCbl) as a cofactor and is widely distributed in organisms from bacteria and animals...
  15. Devi A, Naushad S. Targeted exome sequencing for the identification of complementation groups in methylmalonic aciduria: A south Indian experience. Clin Biochem. 2017;50:68-72 pubmed publisher
    ..Targeted exome sequencing was performed for a panel of MMA causing genes i.e. MUT, ABCD4, ACSF3, CD320, LMBRD1, MCEE, MMAA, MMAB, MMACHC, MMADHC...
  16. Spada M, Calvo P, Brunati A, Peruzzi L, Dell Olio D, Romagnoli R, et al. Early Liver Transplantation for Neonatal-Onset Methylmalonic Acidemia. Pediatrics. 2015;136:e252-6 pubmed publisher
    ..treatment, the clinical course of methylmalonic acidemia due to cobalamin-unresponsive methylmalonyl-CoA mutase (MCM) deficiency is characterized by the persistent risk of recurrent life-threatening decompensation episodes with ..
  17. Kurteva Yaneva N, Zahn M, Weichler M, Starke R, Harms H, Müller R, et al. Structural basis of the stereospecificity of bacterial B12-dependent 2-hydroxyisobutyryl-CoA mutase. J Biol Chem. 2015;290:9727-37 pubmed publisher
    ..compared with the well studied structure of bacterial and mitochondrial B12-dependent methylmalonyl-CoA mutase (MCM), HCM has a highly conserved domain architecture...
  18. Zhao M, Fan Y, Wei L, Hu F, Hua Q. Effects of the Methylmalonyl-CoA Metabolic Pathway on Ansamitocin Production in Actinosynnema pretiosum. Appl Biochem Biotechnol. 2017;181:1167-1178 pubmed publisher
    ..we investigated two key enzymes related to the methylmalonyl-CoA metabolic pathway: methylmalonyl-CoA mutase (MCM) and propionyl-CoA carboxylase (PCC)...
  19. Horster F, Garbade S, Zwickler T, Aydin H, Bodamer O, Burlina A, et al. Prediction of outcome in isolated methylmalonic acidurias: combined use of clinical and biochemical parameters. J Inherit Metab Dis. 2009;32:630 pubmed publisher
    ..asking for age at diagnosis, birth decade, diagnostic work-up, cobalamin responsiveness, enzymatic subgroup (mut(0), mut(-), cblA, cblB) and different aspects of long-term outcome. Results 273 patients were included...
  20. Shen H, Campanello G, Flicker D, Grabarek Z, Hu J, Luo C, et al. The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12. Cell. 2017;171:771-782.e11 pubmed publisher
    ..substrate-analog inhibitor of the mitochondrial B12-dependent methylmalonyl-CoA mutase (MUT)...
  21. Garrett J, Sampson C, Plett P, Crisler R, Parker J, Venezia R, et al. Characterization and Etiology of Swollen Muzzles in Irradiated Mice. Radiat Res. 2019;191:31-42 pubmed publisher
    ..syndrome (H-ARS), and has impeded studies in several laboratories attempting to evaluate medical countermeasures (MCM) against radiation. However, little has been done to characterize this somewhat unpredictable radiation effect...
  22. Gonzalez Sanchez E, Perez M, Nytofte N, Briz O, Monte M, Lozano E, et al. Protective role of biliverdin against bile acid-induced oxidative stress in liver cells. Free Radic Biol Med. 2016;97:466-477 pubmed publisher
    ..deficiency reduces BV-dependent protection against bile acids is a relevant question because a screening of the mut-BLVRA allele (a) in 311 individuals in Greenland revealed that this SNP was relatively frequent in the Inuit ..
  23. Creppy E, Diallo A, Moukha S, Eklu Gadegbeku C, Cros D. Study of epigenetic properties of Poly(HexaMethylene Biguanide) hydrochloride (PHMB). Int J Environ Res Public Health. 2014;11:8069-92 pubmed publisher
    ..p53: mut p53), N2-A (Neuro-2A cells, mouse neural cells), the brain being a possible target organ in rodents and HepG2 cells ..
  24. Ham M, Choe S, Shin K, Choi G, Kim J, Noh J, et al. Glucose-6-Phosphate Dehydrogenase Deficiency Improves Insulin Resistance With Reduced Adipose Tissue Inflammation in Obesity. Diabetes. 2016;65:2624-38 pubmed publisher
    ..Compared with wild-type littermates, G6PD-deficient mutant (G6PD(mut)) mice were glucose tolerant upon high-fat-diet (HFD) feeding...
  25. Yuan B, Yu W, Dai L, Gao Y, Ding Y, Yu X, et al. Expression of microRNA‑26b and identification of its target gene EphA2 in pituitary tissues in Yanbian cattle. Mol Med Rep. 2015;12:5753-61 pubmed publisher
    ..Following the site‑directed mutagenesis of plasmid EphA2 3'‑UTR pmirGLO‑MUT‑ and miR‑26b mimic‑transfected HeLa cells, the dual‑luciferase reporter gene assay ..
  26. Liu Y, Wang H, Wu T, Li X, Song J, DING Y, et al. [A Chinese boy with methylmalonic aciduria cblB type and a novel mutation in the MMAB gene]. Zhongguo Dang Dai Er Ke Za Zhi. 2015;17:172-5 pubmed
    ..Gene analysis was performed by direct sequencing. No mutation in the MUT gene was found. However, a reported mutation c.577G>A (p.E193K) and a novel mutation c.562G>A (p...
  27. Riegger D, Hai R, Dornfeld D, Mänz B, Leyva Grado V, Sánchez Aparicio M, et al. The nucleoprotein of newly emerged H7N9 influenza A virus harbors a unique motif conferring resistance to antiviral human MxA. J Virol. 2015;89:2241-52 pubmed publisher
    ..Accordingly, two substitutions in the NP of PR/8 [PR/8(mut)] to the Mx-sensitive amino acids (P283L and Y313F) led to attenuation in Mx1-positive mice...
  28. Karaca Z, Taheri S, Tanriverdi F, Unluhizarci K, Kelestimur F. Prevalence of AIP mutations in a series of Turkish acromegalic patients: are synonymous AIP mutations relevant?. Pituitary. 2015;18:831-7 pubmed publisher
    In sporadic acromegaly, overall AIP(mut) prevalence is reported as 3, 4.1 and 16 % in studies carried out across Europe. However, it is not known whether the prevalence shows any changes across different ethnicities...
  29. Evans D, Zhang H, Ham H, Pei H, Lee S, Kim J, et al. MMSET is dynamically regulated during cell-cycle progression and promotes normal DNA replication. Cell Cycle. 2016;15:95-105 pubmed publisher
    ..binds to future replication origins, coordinating with multiple factors to load the minichromosome maintenance (MCM) complex onto future replication origins as part of the pre-replication complex (pre-RC)...
  30. Andreatos N, Ronnekleiv Kelly S, Margonis G, Sasaki K, Gani F, Amini N, et al. From bench to bedside: Clinical implications of KRAS status in patients with colorectal liver metastasis. Surg Oncol. 2016;25:332-8 pubmed publisher
    ..This review aimed to summarize currently reported findings on the clinical implications of KRAS mutant (mut-KRAS) status for patients with CRLM...
  31. Cheng W, Lo H, Wang B, Chua S, Lu M, Shyu K. Atorvastatin alleviates cardiomyocyte apoptosis by suppressing TRB3 induced by acute myocardial infarction and hypoxia. J Formos Med Assoc. 2017;116:388-397 pubmed publisher
    ..Hypoxia increased, whereas the TRB3-mut plasmid, SP600125, and TNF-α antibody abolished the hypoxia-induced TRB3 promoter activity...
  32. Hahn N, Bivalacqua T, Ross A, Netto G, Baras A, Park J, et al. A Phase II Trial of Dovitinib in BCG-Unresponsive Urothelial Carcinoma with FGFR3 Mutations or Overexpression: Hoosier Cancer Research Network Trial HCRN 12-157. Clin Cancer Res. 2017;23:3003-3011 pubmed publisher
    ..FGFR3 (pFGFR3) expression by centrally analyzed immunohistochemistry (IHC+) or FGFR3 mutations (Mut+) assessed in a CLIA-licensed laboratory. Patients received oral dovitinib 500 mg daily (5 days on/2 days off)...
  33. Schulze A, Tran C, Levandovskiy V, Patel V, Cortez M. Systemic availability of guanidinoacetate affects GABAA receptor function and seizure threshold in GAMT deficient mice. Amino Acids. 2016;48:2041-7 pubmed publisher
    ..5 mg/kg, I.P.) in Gamt(MUT) and Gamt(WT) groups [n = 3, mean age (SEM) = 6.9 (0.2) weeks]...
  34. Moon K, Kim J, Sohn Y, Cho D, Kim Y, Avdeev M. Crystal structures and color properties of new complex perovskite oxynitrides AMg0.2Ta0.8O2.6N0.4 (A = Sr, Ba). Dalton Trans. 2016;45:5614-21 pubmed publisher
    ..2Ta0.8O2.6N0.4 is simple cubic (Pm3[combining macron]m) and SrMg0.2Ta0.8O2.6N0.4 is body-centered tetragonal (I4/mcm), isostructural with BaM0.2Ta0.8O2.8N0.2 and SrM0.2Ta0.8O2.8N0.2 (M = Li, Na), respectively. The nitrogen in SrMg0...
  35. Geng H, Li R, Su Y, Xiao J, Pan M, Cai X, et al. The Circular RNA Cdr1as Promotes Myocardial Infarction by Mediating the Regulation of miR-7a on Its Target Genes Expression. PLoS ONE. 2016;11:e0151753 pubmed publisher
    ..Cdr1as overexpression in MCM cells promoted cell apoptosis, but was then reversed by miR-7a overexpression...
  36. Shormanov V, Andreeva Y, Omel chenko V. [Peculiarities of detection of 4-nitro-3-(trifluoromethyl)-aniline in the biological material]. Sud Med Ekspert. 2016;59:31-37 pubmed publisher
    ..was shown that this compound is possible to separate from endogenous biomaterials on the silicagel L column (40/100 mcm)...
  37. Peng L, Xu T, Long T, Zuo H. Association Between BRCA Status and P53 Status in Breast Cancer: A Meta-Analysis. Med Sci Monit. 2016;22:1939-45 pubmed
    ..503, 95% CI=1.493-4.198). No difference was found between p53 protein expression in BRCA2 Mut carriers and non-carriers (OR=0.881, 95% CI=0.670-1.158)...
  38. Zacchè M, Giarenis I, Thiagamoorthy G, Robinson D, Cardozo L. Is there a link between preoperative fluoroscopic cough stress testing and synthetic midurethral tape outcome?. Eur J Obstet Gynecol Reprod Biol. 2015;193:61-4 pubmed publisher
    ..study was to assess the utility of fluoroscopic cough stress testing as a predictor of synthetic midurethral tape (MUT) outcome...
  39. Laganà A, Triolo O, D Amico V, Cartella S, Sofo V, Salmeri F, et al. Management of women with epilepsy: from preconception to post-partum. Arch Gynecol Obstet. 2016;293:493-503 pubmed publisher
    ..Major congenital malformations (MCM) such as cleft lip and cleft palate, heart defects (atrial septal defect, Fallot's tetralogy, ventricular septal ..
  40. Geng H, Li R, Su Y, Xiao J, Pan M, Cai X, et al. Curcumin protects cardiac myocyte against hypoxia-induced apoptosis through upregulating miR-7a/b expression. Biomed Pharmacother. 2016;81:258-64 pubmed publisher
    ..In vitro experiments, mouse cardiac myocytes (MCM) subjected to hypoxia after the incubation of curcumin, miR-7a/b and SP1 expression levels were detected by real-..
  41. Papadimitrakopoulou V, Lee J, Wistuba I, Tsao A, Fossella F, Kalhor N, et al. The BATTLE-2 Study: A Biomarker-Integrated Targeted Therapy Study in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer. J Clin Oncol. 2016;: pubmed
    ..Two hundred patients, 27% with KRAS-mutated (KRAS mut+) tumors, were adaptively randomly assigned to erlotinib (n = 22), erlotinib plus MK-2206 (n = 42), MK-2206 plus ..
  42. Taylor Pashow K, Rocca J, Lin W. Mesoporous Silica Nanoparticles with Co-Condensed Gadolinium Chelates for Multimodal Imaging. Nanomaterials (Basel). 2011;2:1-14 pubmed publisher
    ..5-28.8 wt %). These MSN contrast agents, with an MCM-41 type pore structure, were characterized using a variety of methods including SEM and TEM, nitrogen adsorption ..
  43. Ma Y, Yang H, Chen X, Sun B, Du G, Zhou Z, et al. Significantly improving the yield of recombinant proteins in Bacillus subtilis by a novel powerful mutagenesis tool (ARTP): Alkaline α-amylase as a case study. Protein Expr Purif. 2015;114:82-8 pubmed publisher
    ..subtilis WB600 mut-12#. The yield and productivity of recombinant AMY in B. subtilis WB600 mut-12# increased 35.0% and 8...
  44. Poulain S, Roumier C, Venet Caillault A, Figeac M, Herbaux C, Marot G, et al. Genomic Landscape of CXCR4 Mutations in Waldenström Macroglobulinemia. Clin Cancer Res. 2016;22:1480-8 pubmed publisher
    Whole-genome sequencing has revealed MYD88 L265P and CXCR4 mutations (CXCR4(mut)) as the most prevalent somatic mutations in Waldenström macroglobulinemia...
  45. Fernandes C, Rudić S, Vaz P, Nunes C. Looking inside the pores of a MCM-41 based Mo heterogeneous styrene oxidation catalyst: an inelastic neutron scattering study. Phys Chem Chem Phys. 2016;18:17272-80 pubmed publisher
    ..INS also allowed for an estimation of product selectivity by means of a Job method stressing the power of the technique. ..
  46. Becker Krail D, Farrand A, Boger H, Lavin A. Effects of fingolimod administration in a genetic model of cognitive deficits. J Neurosci Res. 2017;95:1174-1181 pubmed publisher
    ..Both wild-type (WT) and mutant (MUT) genotypes were tested for sociability and recognition memory, followed by measuring endogenous BDNF levels and ..
  47. Fazaeli Y, Feizi S, Jalilian A, Hejrani A. Grafting of [(64)Cu]-TPPF20 porphyrin complex on Functionalized nano-porous MCM-41 silica as a potential cancer imaging agent. Appl Radiat Isot. 2016;112:13-9 pubmed publisher
    Mesoporous silica, MCM-41, functionalized with 3-aminopropyltriethoxysilane (APTES) was investigated as a potential drug delivery system, using [(64)Cu]-5, 10, 15, 20-tetrakis penta fluorophenyl porphyrin complex...
  48. Monga I, Qureshi A, Thakur N, Gupta A, Kumar M. ASPsiRNA: A Resource of ASP-siRNAs Having Therapeutic Potential for Human Genetic Disorders and Algorithm for Prediction of Their Inhibitory Efficacy. G3 (Bethesda). 2017;7:2931-2943 pubmed publisher
    ..ASPsiPred is a two-layered algorithm to predict efficacy of ASP-siRNAs for fully complementary mutant (Effmut) and wild-type allele (Effwild) with one mismatch by ASPsiPredSVM and ..
  49. Ludwig M, Matthews R. Structure-based perspectives on B12-dependent enzymes. Annu Rev Biochem. 1997;66:269-313 pubmed
    ..The intermediate radical species generated in catalysis are sequestered in the relatively hydrophilic core of an alpha/beta barrel domain of the mutase. ..
  50. Kulkarni V, Naqvi A, Uttamani J, Nares S. MiRNA-Target Interaction Reveals Cell-Specific Post-Transcriptional Regulation in Mammalian Cell Lines. Int J Mol Sci. 2016;17: pubmed publisher
    ..Dual luciferase assays show that compared to mutant (mut), the reporter gene containing wild type (wt) let-7a binding sites was efficiently suppressed upon transfection in ..
  51. Kaur A, Katiyar S, Kushwah V, Jain S. Nanoemulsion loaded gel for topical co-delivery of clobitasol propionate and calcipotriol in psoriasis. Nanomedicine. 2017;13:1473-1482 pubmed publisher
    ..The optimized ratio of 5:3:2 of Capmul MCM C8 EP, Cremophor RH 40 and Labrafil 1944 CS was selected...
  52. Liu Y, Liu S, Yuan S, Yu H, Zhang Y, Yang X, et al. Chromodomain protein CDYL is required for transmission/restoration of repressive histone marks. J Mol Cell Biol. 2017;9:178-194 pubmed publisher
    ..corepressor, is physically associated with chromatin assembly factor 1 (CAF-1) and the replicative helicase MCM complex...
  53. Sakhon O, Ross B, Gusti V, Pham A, Vu K, Lo D. M cell-derived vesicles suggest a unique pathway for trans-epithelial antigen delivery. Tissue Barriers. 2015;3:e1004975 pubmed publisher
    ..Interestingly, we identified a population of previously undescribed M cell-derived vesicles (MCM) that are constitutively shed into the subepithelial space and readily taken up by CX3CR1(+)CD11b(+) CD11c(+) ..
  54. Sabatinos S, Ranatunga N, Yuan J, Green M, Forsburg S. Replication stress in early S phase generates apparent micronuclei and chromosome rearrangement in fission yeast. Mol Biol Cell. 2015;26:3439-50 pubmed publisher
    ..We analyze a fission yeast mutant that is unable to complete S phase due to a defective subunit of the MCM helicase...
  55. Nakazaki Y, Tsuyama T, Seki M, Takahashi M, Enomoto T, Tada S. Excess Cdt1 inhibits nascent strand elongation by repressing the progression of replication forks in Xenopus egg extracts. Biochem Biophys Res Commun. 2016;470:405-410 pubmed publisher
    Cdt1 is a protein essential for initiation of DNA replication; it recruits MCM helicase, a core component of the replicative DNA helicase, onto replication origins...
  56. Collantes J, Solari F, Rigouts L. Rapid Detection of Mycobacterium tuberculosis Strains Resistant to Isoniazid and/or Rifampicin: Standardization of Multiplex Polymerase Chain Reaction Analysis. Am J Trop Med Hyg. 2016;95:1257-1264 pubmed
    ..Multiplex 1 showed 90%, 95%, and 100% efficiency for wild type (WT), Mut katGS315T, and Mut rpoBS531L, respectively; whereas Multiplex 2 showed 97%, 94%, and 90% efficiency for WT, Mut ..
  57. Das K, Gosal J, Singh S, Mehrotra A, Jaiswal A, Jaiswal S, et al. Solitary Cysticercal Cyst Inside the Blake's Pouch Remnant of Mega Cisterna Magna with Associated Aqueductal Stenosis: Clinical and Management Implications. World Neurosurg. 2017;102:693.e1-693.e5 pubmed publisher
    ..Cysticercal encystation inside the Blake's pouch remnant of mega cisterna magna (MCM) remains an extremely rare clinical scenario that, to the best of our knowledge, has not been reported previously...
  58. Maheshwari P, Dutta D, Mukherjee S, Madhu P, Mote K, Pujari P. Positron annihilation and nuclear magnetic resonance study of the phase behavior of water confined in mesopores at different levels of hydration. Phys Chem Chem Phys. 2016;18:12886-95 pubmed publisher
    We investigated the molecular origin of the phase behavior of water confined in MCM 41 mesopores at different levels of hydration using positron annihilation spectroscopic and nuclear magnetic resonance techniques...
  59. Nairi V, Medda L, Monduzzi M, Salis A. Adsorption and release of ampicillin antibiotic from ordered mesoporous silica. J Colloid Interface Sci. 2017;497:217-225 pubmed publisher
    In this work the adsorption and the release of ampicillin - a β-lactam penicillin-like antibiotic - from MCM-41, SBA-15, and (amino functionalized) SBA-15-NH2 ordered mesoporous silica (OMS) materials were investigated...
  60. Yeom D, Son H, Kim J, Kim S, Lee S, Song S, et al. Development of a solidified self-microemulsifying drug delivery system (S-SMEDDS) for atorvastatin calcium with improved dissolution and bioavailability. Int J Pharm. 2016;506:302-11 pubmed publisher
    ..ATV), we previously introduced an optimized self-microemulsifying drug delivery system (SMEDDS) using Capmul(®) MCM (oil), Tween(®) 20 (surfactant), and tetraglycol (cosurfactant)...
  61. You J, Wang X, Wang J, Yuan B, Zhang Y. DDX59 promotes DNA replication in lung adenocarcinoma. Cell Death Discov. 2017;3:16095 pubmed publisher
    ..DDX59 knockdown caused reduction of MCM protein levels, decreased the loading of MCM ring protein onto chromatin, and therefore inhibited DNA replication...
  62. Trofymchuk I, Roik N, Belyakova L. Structural Variety and Adsorptive Properties of Mesoporous Silicas with Immobilized Oligosaccharide Groups. Nanoscale Res Lett. 2017;12:307 pubmed publisher
    ..Three types of MCM-41 materials were obtained with 0.018, 0.072, and 0...
  63. Werthmann P, Hintze A, Kienle G. Complete remission and long-term survival of a patient with melanoma metastases treated with high-dose fever-inducing Viscum album extract: A case report. Medicine (Baltimore). 2017;96:e8731 pubmed publisher
    Metastatic malignant cutaneous melanoma (MCM)-a highly immunogenic cancer-typically has a poor prognosis. Viscum album extracts (VAEs) have strong immune-stimulating, apoptogenic, and cytotoxic effects...
  64. Riedl V, Utz L, Castrillón G, Grimmer T, Rauschecker J, Ploner M, et al. Metabolic connectivity mapping reveals effective connectivity in the resting human brain. Proc Natl Acad Sci U S A. 2016;113:428-33 pubmed publisher
    ..We propose a novel measure of EC, termed metabolic connectivity mapping (MCM), that integrates undirected functional connectivity (FC) with local energy metabolism from fMRI and positron ..
  65. Namazi H, Rakhshaei R, Hamishehkar H, Kafil H. Antibiotic loaded carboxymethylcellulose/MCM-41 nanocomposite hydrogel films as potential wound dressing. Int J Biol Macromol. 2016;85:327-34 pubmed publisher
    ..hassles, a novel antibiotic-eluting nanocomposite hydrogel was designed via incorporation of mesoporous silica MCM-41 as a nano drug carrier into carboxymethylcellulose hydrogel...
  66. Marmontel O, Di Filippo M, Marcais C, Nony S, Dumoux M, Serveaux Dancer M, et al. Alterations in plasma triglycerides lipolysis in patients with history of multifactorial chylomicronemia. Atherosclerosis. 2017;265:22-28 pubmed publisher
    The heterogeneity and mechanisms of multifactorial chylomicronemia (MCM) remain poorly understood...
  67. Smith C, D Mello S. Cell and Context-Dependent Effects of the Heat Shock Protein DNAJB6 on Neuronal Survival. Mol Neurobiol. 2016;53:5628-39 pubmed publisher
    ..have shown that the heat shock protein, DNAJB6, protects against the proteotoxic effects of mutant huntingtin (mut-Htt) via direct interaction with mut-Htt...
  68. Iovino S, Burkart A, Warren L, Patti M, Kahn C. Myotubes derived from human-induced pluripotent stem cells mirror in vivo insulin resistance. Proc Natl Acad Sci U S A. 2016;113:1889-94 pubmed publisher
    ..muscle insulin resistance by differentiating iPS cells from individuals with mutations in the insulin receptor (IR-Mut) into functional myotubes and characterizing their response to insulin in comparison with controls...
  69. Farjadian F, Ghasemi S, Heidari R, Mohammadi Samani S. In vitro and in vivo assessment of EDTA-modified silica nano-spheres with supreme capacity of iron capture as a novel antidote agent. Nanomedicine. 2017;13:745-753 pubmed publisher
    Mesoporous silica nanoparticles having structure of MCM-41 category with amine and EDTA functional groups in the pores were prepared using a co-condensation reaction...
  70. Sánchez Bastardo N, Alonso E. Maximization of monomeric C5 sugars from wheat bran by using mesoporous ordered silica catalysts. Bioresour Technol. 2017;238:379-388 pubmed publisher
    ..8g of RuCl3/Al-MCM-48 per g of initial carbon in hemicelluloses.
  71. Yau E, Kummetha I, Lichinchi G, Tang R, Zhang Y, Rana T. Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers. Cancer Res. 2017;77:6330-6339 pubmed publisher
    ..of the CRISPR-Cas9 system to identify genes affecting the tumor xenograft growth of human mutant KRAS (KRASMUT) colorectal cancers...
  72. Zajac M, Dolnik A, Stasiak G, Zaleska J, Kielbus M, Czapinski J, et al. Analysis of NPM1 splice variants reveals differential expression patterns of prognostic value in acute myeloid leukemia. Oncotarget. 2017;8:95163-95175 pubmed publisher
    ..12 coding for the nucleolar localization domain, might behave similar to the mutant form of NPM1 (NPM1mut). In accordance, in CN-AML high R2 expression was associated with favorable impact on outcome...
  73. Malkin T, Heard D, Hood C, Stocker J, Carruthers D, Mackenzie I, et al. Assessing chemistry schemes and constraints in air quality models used to predict ozone in London against the detailed Master Chemical Mechanism. Faraday Discuss. 2016;189:589-616 pubmed publisher
    ..The MCM model uses a near-explicit chemical scheme for the oxidation of volatile organic compounds (VOCs) and is ..
  74. Li G, Liu Q, Wu K, Yang Z, Pan S. Na2CdGe2Q6 (Q = S, Se): two metal-mixed chalcogenides with phase-matching abilities and large second-harmonic generation responses. Dalton Trans. 2017;46:2778-2784 pubmed publisher
    ..Furthermore, an interesting space group transformation between the monoclinic (Cc) and tetragonal (I4/mcm) systems from Na2CdGe2Se6 to Na2ZnGe2Se6 was ..
  75. Shormanov V, Pugacheva O, Astashkina A, Tsatsua E. [The specific features of the distribution of 2,6-di-tret-buthyl-4-methlhydroxybenzole in the organism of the warm-blooded animals]. Sud Med Ekspert. 2016;59:29-34 pubmed publisher
    ..It was further purified on the 40/100 mcm L silicagel column with the use of hexane/acetone for elution...
  76. Munch Petersen H, Asmar F, Dimopoulos K, Areškevičiūtė A, Brown P, Girkov M, et al. TP53 hotspot mutations are predictive of survival in primary central nervous system lymphoma patients treated with combination chemotherapy. Acta Neuropathol Commun. 2016;4:40 pubmed publisher
    ..TP53 mutations (MUT-TP53) were investigated in the context of MIR34A/B/C- and DAPK promoter methylation status, and associated with ..
  77. Forough M, Farhadi K, Molaei R, Khalili H, Shakeri R, Zamani A, et al. Capillary electrophoresis with online stacking in combination with AgNPs@MCM-41 reinforced hollow fiber solid-liquid phase microextraction for quantitative analysis of Capecitabine and its main metabolite 5-Fluorouracil in plasma samples isolated fro. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1040:22-37 pubmed publisher
    ..This paper intends to fill this gap and describe a simple off-line sample pretreatment by means of AgNPs@MCM-41 reinforced hollow fiber Solid/Liquid phase microextraction (AgNPs@MCM41-HF-SLPME) with subsequent quantitation ..
  78. Ercan M, Ozalp V, Tuna B. Genotyping of single nucleotide polymorphism by probe-gated silica nanoparticles. Anal Biochem. 2017;537:78-83 pubmed publisher
    ..point mutation (A > G reversion) was developed by designing probe-gated mesoporous silica nanoparticles (MCM-41) loaded with reporter fluorescein molecules...
  79. Zoghbi H, O Brien W, Ledley F. Linkage relationships of the human methylmalonyl CoA mutase to the HLA and D6S4 loci on chromosome 6. Genomics. 1988;3:396-8 pubmed
    The human methylmalonyl CoA mutase (MCM) cDNA has been used to localize the MUT locus on the short arm of chromosome 6 proximal to the glyoxalase locus in 6p deletion cell lines...
  80. Pare G, Chasman D, Parker A, Zee R, Malarstig A, Seedorf U, et al. Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study. Circ Cardiovasc Genet. 2009;2:142-50 pubmed publisher
    ..3; rs6586282; P=3.2 x 10(-10)), we found novel associations with CPS1 (2q34; rs7422339; P=1.9 x 10(-11)), MUT (6p12.3; rs4267943; P=2.0 x 10(-9)), NOX4 (11q14.3; rs11018628; P=9.6 x 10(-12)), and DPEP1 (16q24...
  81. Lin H, Lin J. Immune Cell-Conditioned Media Suppress Prostate Cancer PC-3 Cell Growth Correlating With Decreased Proinflammatory/Anti-inflammatory Cytokine Ratios in the Media Using 5 Selected Crude Polysaccharides. Integr Cancer Ther. 2016;15:NP13-NP25 pubmed
    ..The splenocyte- and macrophage-conditioned media (SCM and MCM) were prepared using individual selected polysaccharides, and then SCM or MCM was further collected to treat PC-3 ..
  82. Tsang T, Hsueh Y, Wei E, Lundy D, Cheng B, Chen Y, et al. Subcellular Localization of Survivin Determines Its Function in Cardiomyocytes. Theranostics. 2017;7:4577-4590 pubmed publisher
    ..SVV knockout transgenic mouse model was established through crossbreeding SVVflox/flox and ?MHC-MCM transgenic mice...
  83. Dai C, Yao X, Gordon E, Barochia A, Cuento R, Kaler M, et al. A CCL24-dependent pathway augments eosinophilic airway inflammation in house dust mite-challenged Cd163(-/-) mice. Mucosal Immunol. 2016;9:702-17 pubmed publisher
    ..dust mite (HDM)-challenged Cd163(-/-) mice displayed increases in airway eosinophils and mucous cell metaplasia (MCM)...
  84. Kinoshita M, Numata S, Tajima A, Nishi A, Muraki S, Tsuchiya A, et al. Cumulative effect of the plasma total homocysteine-related genetic variants on schizophrenia risk. Psychiatry Res. 2016;246:833-837 pubmed publisher
    ..six SNPs examined, we replicated similar associations with the European GWAS at four loci (CENPQ, CPS1, MTHFR, and MUT). GRS based on three SNPs (CENPQ, CPS1, and MTHFR) was significantly associated with SCZ...
  85. Kong L, Yin H, Yuan L. Centrosomal MCM7 strengthens the Cep68-VHL interaction and excessive MCM7 leads to centrosome splitting resulting from increase in Cep68 ubiquitination and proteasomal degradation. Biochem Biophys Res Commun. 2017;489:497-502 pubmed publisher
    ..The minichromosome maintenance (MCM) proteins 2-7 have long been noticed to localize to centrosomes, but their functions at the centrosome are ..
  86. Shormanov V, Tsatsua E, Astashkina A. [The determination of 2,4-di-tret-butyl hydroxybenzene for the purpose of the chemical toxicological study of the biological materials]. Sud Med Ekspert. 2017;60:34-39 pubmed publisher
    ..of the analyte by means of removal of the organic substances of biological matrices using the L 40/100 mcm sorbent columns with the hexan/dioxane mixture (8.5:1.5) as the mobile phase...
  87. Goethals F, Levrau E, De Canck E, Baklanov M, Detavernier C, Van Driessche I, et al. Pore Narrowing of Mesoporous Silica Materials. Materials (Basel). 2013;6:570-579 pubmed publisher
    ..As mesoporous material, the well-studied MCM-41 powder was selected to allow an easy characterization of the grafting reactions...
  88. Han J, Lian M, Fang J, Liu H, Wang R, Zhai J, et al. Minichromosome maintenance (MCM) protein 4 overexpression is a potential prognostic marker for laryngeal squamous cell carcinoma. J BUON. 2017;22:1272-1277 pubmed
    The minichromosomal maintenance (MCM) proteins are involved in the initiation and DNA replication. The role of MCM4 remains to be elucidated...
  89. Liu Y, Wang B, Jiang Y, Cao J, Hao J, Zhang Y, et al. MCMs expression in lung cancer: implication of prognostic significance. J Cancer. 2017;8:3641-3647 pubmed publisher
    Minichromosome Maintenance (MCM) proteins play essential roles in various cancers. We previously reported that MCM7 could be a prognostic biomarker in non-small cell lung cancer (NSCLC)...
  90. Mahmoodi M, Behzad Behbahani A, Sharifzadeh S, Abolmaali S, Tamaddon A. Co-condensation synthesis of well-defined mesoporous silica nanoparticles: effect of surface chemical modification on plasmid DNA condensation and transfection. IET Nanobiotechnol. 2017;11:995-1004 pubmed publisher
    ..and thermal stability with adjustable morphology and porosity; therefore, it was aimed to develop and compare the MCM-41 MSNs functionalised with imidazole groups (MCM-41-Im) to unmodified (MCM-41-OH) and primary amine functionalised ..
  91. Wang Y, Guo H, Zou S, Lyu X, Ling Z, Cheng H, et al. Surface O3 photochemistry over the South China Sea: Application of a near-explicit chemical mechanism box model. Environ Pollut. 2018;234:155-166 pubmed publisher
    ..Additional knowledge was gained when a photochemical box model incorporating the Master Chemical Mechanism (PBM-MCM) was applied to further investigate the differences/similarities of O3 photochemistry between non-..
  92. Keeratichamroen S, Cairns J, Sawangareetrakul P, Liammongkolkul S, Champattanachai V, Srisomsap C, et al. Novel mutations found in two genes of thai patients with isolated methylmalonic acidemia. Biochem Genet. 2007;45:421-30 pubmed
    ..genetic analysis of three patients diagnosed with isolated methylmalonic acidemia (MMA) revealed that one was mut (0) MMA, with a mutation in the MUT gene encoding the L: -methylmalonyl-CoA mutase (MCM), and two were cblB MMA, ..