MUT

Summary

Gene Symbol: MUT
Description: methylmalonyl CoA mutase
Alias: MCM, methylmalonyl Coenzyme A mutase, methylmalonyl-CoA isomerase, methylmalonyl-CoA mutase, mitochondrial
Species: human

Top Publications

  1. doi Minichromosome maintenance protein expression in benign nevi, dysplastic nevi, melanoma, and cutaneous melanoma metastases
    Alan S Boyd
    Department of Medicine Dermatology, Vanderbilt University, Nashville, Tennessee, USA
    J Am Acad Dermatol 58:750-4. 2008
  2. pmc Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes
    L Folgueira
    Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Virol 70:223-31. 1996
  3. pmc Liver-directed recombinant adeno-associated viral gene delivery rescues a lethal mouse model of methylmalonic acidemia and provides long-term phenotypic correction
    Nuria Carrillo-Carrasco
    Organic Acid Research Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health Bethesda, MD 20892, USA
    Hum Gene Ther 21:1147-54. 2010
  4. ncbi Regulation of glutathione S-transferase enzymes in primary cultures of rat hepatocytes maintained under various matrix configurations
    E L LeCluyse
    Department of Pharmacology, Toxicology, and Therapeutics, Center for Environmental and Occupational Health, Kansas University Medical Center, Kansas City, Kansas, USA
    Toxicol In Vitro 14:101-15. 2000
  5. doi Cobalamin deficiency results in an abnormal increase in L-methylmalonyl-co-enzyme-A mutase expression in rat liver and COS-7 cells
    Motoyuki Nakao
    Department of Applied Biological Chemistry, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
    Br J Nutr 101:492-8. 2009
  6. ncbi Molecular analysis and heterologous expression of the gene encoding methylmalonyl-coenzyme A mutase from rifamycin SV-producing strain Amycolatopsis mediterranei U32
    W Zhang
    Department of Microbiology, Shanghai Institute of Plant Physiology, Academia Sinica, P R China
    Appl Biochem Biotechnol 82:209-25. 1999
  7. pmc Primary structure and activity of mouse methylmalonyl-CoA mutase
    M F Wilkemeyer
    Howard Hughes Medical Institute, Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    Biochem J 271:449-55. 1990
  8. ncbi Effect of fetuin, a TGFbeta antagonist and pentoxifylline, a cytokine antagonist on hepatic stellate cell function and fibrotic parameters in fibrosis
    Monica Verma-Gandhu
    Department of Pharmacology Faculty of Medicine Dalhousie University, Canada
    Eur J Pharmacol 572:220-7. 2007
  9. ncbi Initiating DNA synthesis: from recruiting to activating the MCM complex
    M Lei
    Dept of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Cell Sci 114:1447-54. 2001
  10. pmc Genomic structure of murine methylmalonyl-CoA mutase: evidence for genetic and epigenetic mechanisms determining enzyme activity
    M F Wilkemeyer
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    Biochem J 296:663-70. 1993

Research Grants

  1. Chromatin Remodeling by Cdt1: Role in DNA Replication and Tumorigenesis
    MARK GREGORY ALEXANDROW; Fiscal Year: 2010
  2. Regulation of DNA Replication by MCM Proteins
    Jean Gautier; Fiscal Year: 2010
  3. Regulation of DNA Replication by MCM Proteins
    Jean Gautier; Fiscal Year: 2009
  4. Resolution of Epithelial Cell Hyperplasia
    Yohannes Tesfaigzi; Fiscal Year: 2010
  5. Resolution of Epithelial Cell Hyperplasia
    Yohannes Tesfaigzi; Fiscal Year: 2009
  6. GENETIC AND MOLECULAR ANALYSIS OF YEAST DNA REPLICATION
    Robert A Sclafani; Fiscal Year: 2010
  7. GENETIC AND MOLECULAR ANALYSIS OF YEAST DNA REPLICATION
    Robert Sclafani; Fiscal Year: 2009
  8. MECHANISMS OF HUMAN PAPILLOMAVIRUS DNA REPLICATION
    LOUISE CHOW; Fiscal Year: 2009
  9. Regulation of the endo cell cycle in Drosophila
    Terry Orr Weaver; Fiscal Year: 2006
  10. MCM PROTEIN FUNCTION DURING EUKARYOTIC DNA REPLICATION
    Stephen Bell; Fiscal Year: 2002

Detail Information

Publications162 found, 100 shown here

  1. doi Minichromosome maintenance protein expression in benign nevi, dysplastic nevi, melanoma, and cutaneous melanoma metastases
    Alan S Boyd
    Department of Medicine Dermatology, Vanderbilt University, Nashville, Tennessee, USA
    J Am Acad Dermatol 58:750-4. 2008
    Minichromosome maintenance (MCM) proteins are a recently elucidated group of polypeptides intimately involved in DNA replication and appreciable only in cycling cells...
  2. pmc Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes
    L Folgueira
    Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Virol 70:223-31. 1996
    ..In addition, cotransfection of a negative dominant molecule of PKC-zeta (PKC-zeta mut) with NF-kappa B-dependent reporter genes selectively inhibits the HIV- but not phorbol myristate acetate- or ..
  3. pmc Liver-directed recombinant adeno-associated viral gene delivery rescues a lethal mouse model of methylmalonic acidemia and provides long-term phenotypic correction
    Nuria Carrillo-Carrasco
    Organic Acid Research Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health Bethesda, MD 20892, USA
    Hum Gene Ther 21:1147-54. 2010
    ..disorder caused by a deficiency of the ubiquitously expressed mitochondrial enzyme, methylmalonyl-CoA mutase (MUT)...
  4. ncbi Regulation of glutathione S-transferase enzymes in primary cultures of rat hepatocytes maintained under various matrix configurations
    E L LeCluyse
    Department of Pharmacology, Toxicology, and Therapeutics, Center for Environmental and Occupational Health, Kansas University Medical Center, Kansas City, Kansas, USA
    Toxicol In Vitro 14:101-15. 2000
    ..Hepatocytes cultured in serum-free Dulbecco's modified Eagle's medium (DMEM) or modified Chee's medium (MCM) maintained similar levels of total GST protein regardless of the matrix configuration or corresponding cell ..
  5. doi Cobalamin deficiency results in an abnormal increase in L-methylmalonyl-co-enzyme-A mutase expression in rat liver and COS-7 cells
    Motoyuki Nakao
    Department of Applied Biological Chemistry, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
    Br J Nutr 101:492-8. 2009
    ..study was to examine the effects of cobalamin (Cbl) on the activity and expression of L-methylmalonyl-CoA mutase (MCM) in rat liver and cultured COS-7 cells...
  6. ncbi Molecular analysis and heterologous expression of the gene encoding methylmalonyl-coenzyme A mutase from rifamycin SV-producing strain Amycolatopsis mediterranei U32
    W Zhang
    Department of Microbiology, Shanghai Institute of Plant Physiology, Academia Sinica, P R China
    Appl Biochem Biotechnol 82:209-25. 1999
    ..A (CoA) into methylmalonyl-CoA, catalyzed by adenosylcobalamin-dependent methylmalonyl-CoA mutase (MCM), represents an important source of building blocks for rifamycin SV biosynthesis...
  7. pmc Primary structure and activity of mouse methylmalonyl-CoA mutase
    M F Wilkemeyer
    Howard Hughes Medical Institute, Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    Biochem J 271:449-55. 1990
    Methylmalonyl-CoA mutase (MCM) is an adenosylcobalamin-dependent enzyme that catalyses isomerization between methylmalonyl-CoA and succinyl-CoA (3-carboxypropionyl-CoA)...
  8. ncbi Effect of fetuin, a TGFbeta antagonist and pentoxifylline, a cytokine antagonist on hepatic stellate cell function and fibrotic parameters in fibrosis
    Monica Verma-Gandhu
    Department of Pharmacology Faculty of Medicine Dalhousie University, Canada
    Eur J Pharmacol 572:220-7. 2007
    We have previously shown that monocyte conditioned medium (MCM) from patients with liver fibrosis stimulated proliferation of hepatic stellate cells (HSCs), the major cell involved in hepatic fibrosis...
  9. ncbi Initiating DNA synthesis: from recruiting to activating the MCM complex
    M Lei
    Dept of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Cell Sci 114:1447-54. 2001
    ..A key component of the pre-RC is the hexameric MCM complex, which is also the presumed helicase of the growing forks...
  10. pmc Genomic structure of murine methylmalonyl-CoA mutase: evidence for genetic and epigenetic mechanisms determining enzyme activity
    M F Wilkemeyer
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    Biochem J 296:663-70. 1993
    Methylmalonyl-CoA mutase (MCM) is a nuclear-encoded mitochondrial matrix enzyme...
  11. pmc Adenoviral-mediated correction of methylmalonyl-CoA mutase deficiency in murine fibroblasts and human hepatocytes
    Randy J Chandler
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Med Genet 8:24. 2007
    ..by deficiency of the mitochondrial localized, 5'deoxyadenosylcobalamin dependent enzyme, methylmalonyl-CoA mutase (MUT)...
  12. ncbi Mutation and haplotype analyses of the MUT gene in Japanese patients with methylmalonic acidemia
    Osamu Sakamoto
    Department of Pediatrics, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    J Hum Genet 52:48-55. 2007
    Methylmalonic acidemia (MMA) is caused by a deficiency in the activity of L: -methylmalonyl-CoA mutase (MCM), a vitamin B12 (or cobalamin, Cbl)-dependent enzyme...
  13. pmc Adenovirus-mediated gene delivery rescues a neonatal lethal murine model of mut(0) methylmalonic acidemia
    Randy J Chandler
    Genetic Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Gene Ther 19:53-60. 2008
    ..MMA), an autosomal recessive metabolic disorder, is most often caused by mutations in methylmalonyl-CoA mutase (MUT)...
  14. ncbi Identification of the human and bovine ATP:Cob(I)alamin adenosyltransferase cDNAs based on complementation of a bacterial mutant
    Nicole A Leal
    Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida 32611, USA
    J Biol Chem 278:9227-34. 2003
    In humans, deficiencies in coenzyme B12-dependent methylmalonyl-CoA mutase (MCM) lead to methylmalonyl aciduria, a rare disease that is often fatal in newborns...
  15. ncbi Cloning, expression and sequence analysis of the genes encoding the heterodimeric methylmalonyl-CoA mutase of Porphyromonas gingivalis W50
    C A Jackson
    Biochemistry and Molecular Biology Unit, School of Dental Science, University of Melbourne, Australia
    Gene 167:127-32. 1995
    Two genes that encode methylmalonyl-CoA mutase (MCM) have been characterised in Porphyromonas gingivalis W50 (Pg)...
  16. doi Theoretical analysis of the diradical nature of adenosylcobalamin cofactor-tyrosine complex in B12-dependent mutases: inspiring PCET-driven enzymatic catalysis
    Pawel M Kozlowski
    Department of Chemistry, University of Louisville, Louisville, Kentucky 40292, USA
    J Phys Chem B 114:5928-39. 2010
    ..In particular, methylmalonyl-CoA mutase (MCM) and glutamate mutase (GLM) enzymes have been studied; in the case of MCM, the significance of the Y89 residue has ..
  17. ncbi Experimental study on mechanism and rarity of metastases in skeletal muscle
    Chenghua Luo
    Department of General Surgery, 301 Hospital, Beijing 100853, China
    Chin Med J (Engl) 115:1645-9. 2002
    ..To investigate the reasons for the rarity of metastases in skeletal muscle...
  18. pmc Association of germline mutations in the fumarate hydratase gene and uterine fibroids in women with hereditary leiomyomatosis and renal cell cancer
    Laveta Stewart
    Division of Cancer Epidemiology and Genetics, Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health, Rockville, MD 20892 7231, USA
    Arch Dermatol 144:1584-92. 2008
    ..To investigate the risk of uterine fibroids and other reproductive risk factors in women with hereditary leiomyomatosis and renal cell cancer (HLRCC)...
  19. doi Comparing the General Practice Research Database and the UK Epilepsy and Pregnancy Register as tools for postmarketing teratogen surveillance: anticonvulsants and the risk of major congenital malformations
    Rachel A Charlton
    Department of Pharmacy and Pharmacology, University of Bath, Bath, UK
    Drug Saf 34:157-71. 2011
    ....
  20. ncbi [Couples' knowledge and attitudes regarding the practice of family planning in the jungle of Peru]
    Doris de la Cruz-Peñarán
    Instituto Nacional de Salud Pública INSP, Avenida Universidad 655, colonia Santa María, Ahuacatitlán 62508 Cuernavaca, Morelos, Mexico
    Salud Publica Mex 45:461-71. 2003
    ..To assess the association of knowledge and attitudes about family planning (FP) with its practice in couples of the Peruvian jungle region...
  21. pmc Analysis of genomic instability in Li-Fraumeni fibroblasts with germline p53 mutations
    P K Liu
    Division of Laboratory Medicine, Department of Tumor Biology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Oncogene 12:2267-78. 1996
    ..We used p53(wt/mut) and p53(mut/-) LFS fibroblasts, and p53(-/-) non-LFS cells...
  22. doi Flavin adenine dinucleotide status and the effects of high-dose riboflavin treatment in short-chain acyl-CoA dehydrogenase deficiency
    Bianca T van Maldegem
    Department of Pediatrics, University of Amsterdam, Amsterdam, The Netherlands
    Pediatr Res 67:304-8. 2010
    ..in a prospective open-label cohort study involving 16 patients with SCADD, subdivided into mutation/mutation (mut/mut), mutation/variant (mut/var), and variant/variant (var/var) genotype groups...
  23. pmc Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity
    Juliane G Strauss
    Institute of Molecular Biology, Biochemistry and Microbiology, University of Graz, Harrachgasse 21, A 8010 Graz, Austria
    Biochem J 368:69-79. 2002
    ..by the finding that, in contrast with EDL, the amount of cell-surface-bound enzymically inactive mutant EDL (MUT-EDL) was not reduced in the presence of HDL and foetal calf serum...
  24. ncbi Sorbitol co-feeding reduces metabolic burden caused by the overexpression of a Rhizopus oryzae lipase in Pichia pastoris
    Ramon Ramon
    Departament d Enginyeria Quimica, ETSE, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Biotechnol 130:39-46. 2007
    ..Remarkably, a different substrate consumption behaviour was observed depending on the host's phenotype (Mut(+) or Mut(s)) in batch cultures: when the methanol assimilation capacity is genetically reduced (Mut(s) phenotype), ..
  25. doi Involvement of toll-like receptor 4 in alveolar bone loss and glucose homeostasis in experimental periodontitis
    K Watanabe
    Department of Periodontics, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612 7212, USA
    J Periodontal Res 46:21-30. 2011
    ..We therefore hypothesized that mice with periodontitis and a TLR4 loss-of-function (LOF) mutation fed a high-fat (HF) diet would develop improved glucose homeostasis compared with wild-type (WT) animals with periodontitis fed a HF diet...
  26. ncbi Long-lasting effects of chronic ozone exposure on rat nasal epithelium
    J R Harkema
    Department of Pathology, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    Am J Respir Cell Mol Biol 20:517-29. 1999
    ..We have recently reported that long-term inhalation exposure to ozone causes mucous-cell metaplasia (MCM) in the surface epithelium lining the nasal airways of F344 rats...
  27. ncbi T-->G or T-->A mutation introduced in the branchpoint consensus sequence of intron 4 of lecithin:cholesterol acyltransferase (LCAT) gene: intron retention causing LCAT deficiency
    M Li
    Atherosclerosis Specialty Laboratory, Department of Pathology and Laboratory Medicine, St Paul s Hospital and University of British Columbia, 1081 Burrard Street, Vancouver, British Columbia, Canada
    Biochim Biophys Acta 1391:256-64. 1998
    ..e., LCAT Int-4 MUT-1 (T-->G) and LCAT Int-4 MUT-2 (T-->A)...
  28. ncbi The nuclear envelope prevents reinitiation of replication by regulating the binding of MCM3 to chromatin in Xenopus egg extracts
    M A Madine
    Wellcome CRC Institute, Cambridge, UK
    Curr Biol 5:1270-9. 1995
    A complex of MCM proteins is implicated in ensuring that DNA replicates only once in each cell cycle, by 'replication licensing'...
  29. ncbi Physical and functional interaction between the mini-chromosome maintenance-like DNA helicase and the single-stranded DNA binding protein from the crenarchaeon Sulfolobus solfataricus
    Floriana Carpentieri
    Istituto di Biochimica delle Proteine, Consiglio Nazionale delle Ricerche, Via P Castellino 111, Napoli 80131, Italy
    J Biol Chem 277:12118-27. 2002
    Mini-chromosome Maintenance (MCM) proteins play an essential role in both initiation and elongation phases of DNA replication in Eukarya...
  30. pmc Altered expression of cell cycle and apoptotic proteins in chronic hepatitis C virus infection
    Saira Sarfraz
    1Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    BMC Microbiol 8:133. 2008
    ..and normal histology (n = 5) were analyzed by immunohistochemistry using antibodies against proliferation marker Mcm-2, G1 phase marker Cyclin D1, S phase marker Cyclin A, cell cycle regulators p21 (CDK inhibitor) and p53 (tumor ..
  31. ncbi Functional localization and competition between the androgen receptor and T-cell factor for nuclear beta-catenin: a means for inhibition of the Tcf signaling axis
    David J Mulholland
    The Prostate Centre, Jack Bell Research, Vancouver, BC, Canada V6H 3Z6
    Oncogene 22:5602-13. 2003
    ..Transient transfections in SW480 cells (APC(mut/mut)) showed that this mode of repression is functionally independent of APC-mediated beta-catenin ubiquitination...
  32. ncbi [Histologic study of local infiltration of spinal bone giant cell tumor and chordoma]
    Jie Lan
    Department of Orthopedics, Peking University Third Hospital, Beijing 100191, China
    Zhonghua Wai Ke Za Zhi 46:1808-11. 2008
    ..To study the local infiltration length of spinal bone giant cell tumor and chordoma in various para-tumorous tissues...
  33. pmc Virulence variation among isolates of western equine encephalitis virus in an outbred mouse model
    Christopher H Logue
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA
    J Gen Virol 90:1848-58. 2009
    ..f.u. of each virus. Two WEEV strains, McMillan (McM) and Imperial 181 (IMP), were the most divergent of the six in genome sequence; McM caused 100 % mortality by 5 ..
  34. doi Accelerated oxidation of epinephrine by silica nanoparticles
    Zhimin Tao
    Department of Chemistry, Syracuse University, Syracuse, New York 13244, USA
    Langmuir 25:10183-8. 2009
    We have measured the influence of mesoporous silica (MCM-41 and SBA-15) nanoparticles and dense silica nanoparticles on epinephrine oxidation, a pH-dependent reaction, whose rate is small in acidic or neutral solutions but much greater ..
  35. pmc An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection
    Mark S Pearson
    Division of Infectious Diseases, Queensland Institute of Medical Research and The Australian Centre for Vaccine Development, Brisbane, Australia
    FASEB J 23:3007-19. 2009
    ..Toward developing a human hookworm vaccine, we expressed both wild-type (Na-APR-1(wt)) and mutant (Na-APR-1(mut)-mutagenesis of the catalytic aspartic acids) forms of Na-APR-1 from the human hookworm, Necator americanus...
  36. ncbi Modular organization of the Sulfolobus solfataricus mini-chromosome maintenance protein
    Biagio Pucci
    Istituto di Biochimica delle Proteine, Consiglio Nazionale Ricerche, Via P Castellino, 111, 80131 Napoli, Italy
    J Biol Chem 282:12574-82. 2007
    Mini-chromosome maintenance (MCM) proteins form ring-like hexameric complexes that are commonly believed to act as the replicative DNA helicase at the eukaryotic/archaeal DNA replication fork...
  37. doi Methanococcus maripaludis: an archaeon with multiple functional MCM proteins?
    Alison D Walters
    Department of Biology Area 5, PO Box 373, University of York, York YO10 5YW, UK
    Biochem Soc Trans 37:1-6. 2009
    ..Key proteins involved in the initiation and elongation phases of DNA replication include the MCM (minchromosome maintenance) proteins, MCM2-MCM7, a family of six related proteins believed to act as the ..
  38. ncbi Glucose-6 phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II
    Reiko Matsui
    Vascular Biology Unit, Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mass 02118 2393, USA
    Circulation 112:257-63. 2005
    ..We determined the hypertensive and vascular hypertrophic response to Ang II in G6PD-deficient mice...
  39. ncbi Improvement of dissolution rate of piroxicam by inclusion into MCM-41 mesoporous silicate
    V Ambrogi
    Dipartimento di Chimica e Tecnologia del Farmaco, Via del Liceo 1, Perugia, Italy
    Eur J Pharm Sci 32:216-22. 2007
    The aim of the present paper was the use of mesoporous silicate MCM-41 to increase the dissolution rate of piroxicam, a non-steroidal anti-inflammatory drug-class II of the Biopharmaceutic Classification System...
  40. pmc Cloning and characterization of mouse intestinal MUC3 mucin: 3' sequence contains epidermal-growth-factor-like domains
    L L Shekels
    Department of Medicine, University of Minnesota and VA Medical Center, Minneapolis, MN 55417, USA
    Biochem J 330:1301-8. 1998
    ..We report here the cloning of a mouse caecal mucin (MCM). Amino acid analysis of purified MCM revealed a high content of serine (10.8%) and threonine (25.1%)...
  41. ncbi Study on the indoor volatile organic compound treatment and performance assessment with TiO2/MCM-41 and TiO2/quartz photoreactor under ultraviolet irradiation
    Chia Wei Tsai
    Department of Environmental Engineering, National I Lan University, Taiwan, Republic of China
    J Air Waste Manag Assoc 58:1266-73. 2008
    ..activated by visible irradiation and packed with TiO2/quartz or TiO2/mobile catalytic material number 41 (MCM-41)...
  42. pmc Calcicludine binding to the outer pore of L-type calcium channels is allosterically coupled to dihydropyridine binding
    Xianming Wang
    Department of Cellular and Molecular Physiology, The Penn State Milton S Hershey College of Medicine, Hershey, Pennsylvania 17033, USA
    Biochemistry 46:7590-8. 2007
    ..segment of repeat III were sequentially changed to alanine in groups of three, resulting in the mutant channels, Mut-A, Mut-B, and Mut-C. Mut-A, whose substitutions are proximal to IIIS5, exhibits a 4...
  43. ncbi Immunohistochemical evaluation of metallothionein, Mcm-2 and Ki-67 antigen expression in tumors of the adrenal cortex
    Artur Szajerka
    Second Department of General and Oncological Surgery, Medical University, M Curie Sklodowska Street 66, Poland
    Anticancer Res 28:2959-65. 2008
    The aim of this study was to assess the metallothionein (MT), maintenance protein 2 (Mcm-2) and Ki-67 expressions in adrenocortical adenomas and carcinomas in comparison to normal tissue and evaluate the correlations between these ..
  44. doi Induction of glioma apoptosis by microglia-secreted molecules: The role of nitric oxide and cathepsin B
    So Young Hwang
    Department of Physiology and Biophysics, and Center for Advanced Medical Education by BK21 Project, Inha University, College of Medicine, Nam Ku, Incheon 402 751, Korea
    Biochim Biophys Acta 1793:1656-68. 2009
    ..Microglia conditioned culture medium (MCM) actively stimulated apoptotic death of glioma cells, and the effects of MCM prepared from LPS- or IFN-gamma-..
  45. ncbi The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin
    P Romanowski
    Wellcome CRC Institute, Cambridge
    Curr Biol 6:1416-25. 1996
    The origin recognition complex (ORC) and the minichromosome maintenance (MCM) protein complex were initially discovered in yeast and shown to be essential for DNA replication...
  46. ncbi The influence of flotation solution, sample dilution and the choice of McMaster slide area (volume) on the reliability of the McMaster technique in estimating the faecal egg counts of gastrointestinal strongyles and Dicrocoelium dendriticum in sheep
    G Cringoli
    Dipartimento di Patologia e Sanita Animale, Facolta di Medicina Veterinaria, Universita degli Studi di Napoli Federico II, CREMOPAR Regione Campania, Via Della Veterinaria 1, 80137 Napoli, Italy
    Vet Parasitol 123:121-31. 2004
    ..For each McMaster slide, the GI strongyle and D. dendriticum egg counts were performed under one grid (McM 0.15 ml), two grids (McM 0.3 ml), one chamber (McM 0.5 ml), and both chambers (McM 1.0 ml)...
  47. doi Determination of very low levels of gold and palladium in wastewater and soil samples by atomic absorption after preconcentration on modified MCM-48 and MCM-41 silica
    H Ebrahimzadeh
    Department of Chemistry, Shahid Beheshti University, G C, Evin, Tehran, Iran
    Talanta 81:1183-8. 2010
    ..Extraction was investigated on adsorbents prepared by grafting aminopropyl on the surface of MCM-41 and MCM-48 mesoporous silica...
  48. ncbi Kinetics and thermodynamics of the adsorption of some dyestuffs and p-nitrophenol by chitosan and MCM-chitosan from aqueous solution
    Ilhan Uzun
    Department of Chemistry, Faculty of Education, Dicle University, 21280 Diyarbakir, Turkey
    J Colloid Interface Sci 274:398-412. 2004
    ..Sigma C-3646) and the effect of temperature on the adsorption of O-II and CV by monocarboxymethylated chitosan (MCM-chitosan) were investigated...
  49. pmc A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae
    Bo Huang
    Department of Molecular Biology, Umea University, 901 87 Umea, Sweden
    RNA 14:2183-94. 2008
    ..tRNA(mcm5s2UUU Lys), and tRNA(mcm5s2UUG Gln) 3' of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine (mcm(5)s(2)U)...
  50. pmc Specific targeting to B cells by lipid-based nanoparticles conjugated with a novel CD22-ScFv
    Kristin Loomis
    Center for Cancer Research Nanobiology Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702 1201, USA
    Exp Mol Pathol 88:238-49. 2010
    ..Therefore, we generated a mutant of the targeting segment of HA22 (a CD22 scFv) to increase its soluble expression (mut-HA22), and conjugated it to the surface of sonicated liposomes to generate immunoliposomes (mut-HA22-liposomes)...
  51. ncbi Photophysical Properties of Lanthanide Hybrids Covalently Bonded To Functionalized MCM-41 by Modified Aromatic Carboxylic Acids
    Ying Li
    Department of Chemistry, Tongji University, Shanghai, 200092, People s Republic of China
    J Fluoresc 19:191-201. 2009
    b>MCM-41 mesoporous silica has been functionalized with aromatic carboxylic acids salicylic acid (Sal) and 2-hydroxyl-3-methylbenzoic acid (HMBA) through co-condensation approach of tetraethoxysilane (TEOS) in the presence of the ..
  52. ncbi Omeprazole treatment of Korean patients: effects on gastric pH and gastrin release in relation to CYP2C19 geno- and phenotypes
    Hyung Keun Roh
    Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Basic Clin Pharmacol Toxicol 95:112-9. 2004
    ..patients with acid related disease were genotyped for CYP2C19 by allele specific PCR (wt/wt, CYP2C19*1/*1; wt/mut, CYP2C19*1/*2 or *1/*3; mut/mut, CYP2C19*2/*2, *2/*3 or *3/*3)...
  53. doi Novel and existing mutations in the tyrosine kinase domain of the epidermal growth factor receptor are predictors of optimal resectability in malignant peritoneal mesothelioma
    Jason M Foster
    Division of Surgical Oncology, Creighton University Medical Center, Creighton University, Omaha, NE 68131, USA
    Ann Surg Oncol 16:152-8. 2009
    ..and their tumors were probed for point mutations in the catalytic TK domain of epidermal growth factor receptor (mut+)...
  54. pmc The Nrf2-inducible antioxidant defense in astrocytes can be both up- and down-regulated by activated microglia:Involvement of p38 MAPK
    Fernando Correa
    Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Sweden
    Glia 59:785-99. 2011
    The effects of microglia-conditioned medium (MCM) on the inducible Nrf2 system in astrocyte-rich cultures were investigated by determination of glutathione (GSH) levels, γglutamylcysteine ligase (γGCL) activity, the protein levels of ..
  55. doi Effects of lipophilic components on the compatibility of lipid-based formulations with hard gelatin capsules
    Feng Jing Chen
    Boehringer Ingelheim Pharmaceuticals Inc, 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA
    J Pharm Sci 99:128-41. 2010
    ..1) and an additional lipophilic excipient (Capmul MCM) significantly affected the activity of PG in the fills and the equilibrium of PG between capsule shells and fills...
  56. pmc Immunohistochemical estimation of cell cycle phase in laryngeal neoplasia
    P Chatrath
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge CB2 2XZ, UK
    Br J Cancer 95:314-21. 2006
    ..Antibodies against the markers of cell cycle entry, minichromosome maintenance protein-2 (Mcm-2) and Ki67, and putative markers of cell cycle phase, cyclin D1 (G1-phase), cyclin A (S-phase), cyclin B1 (G2-..
  57. ncbi Nuclear envelope alterations in fibroblasts from LGMD1B patients carrying nonsense Y259X heterozygous or homozygous mutation in lamin A/C gene
    Antoine Muchir
    INSERM U582, Institut de Myologie, Groupe Hospitalier Pitie Salpetriere, 75013, Paris, France
    Exp Cell Res 291:352-62. 2003
    ..limb-girdle muscular dystrophy and from her deceased newborn grandchild carrying, respectively, a heterozygous (+/mut) and a homozygous (mut/mut) nonsense Y259X mutation...
  58. pmc Interactions between the archaeal Cdc6 and MCM proteins modulate their biochemical properties
    Rajesh Kasiviswanathan
    University of Maryland Biotechnology Institute, Center for Advanced Research in Biotechnology, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    Nucleic Acids Res 33:4940-50. 2005
    The origin recognition complex, Cdc6 and the minichromosome maintenance (MCM) complex play essential roles in the initiation of eukaryotic DNA replication...
  59. ncbi Using mesoporous silica MCM-41 for in-line enrichment of atmospheric volatile organic compounds
    Tung Min Wu
    Department of Chemistry, National Central University, Chungli 320, Taiwan
    J Chromatogr A 1105:168-75. 2006
    A mesoporous silica MCM-41 with pore size of 29A was synthesized and assessed for its applicability as a sorbent for in-line trapping of volatile organic compounds (VOCs) from air samples...
  60. doi Microglial regulation of cholinergic differentiation in the basal forebrain
    G Miller Jonakait
    Federated Department of Biological Sciences, New Jersey Institute of Technology, Newark, New Jersey, USA
    Dev Neurobiol 72:857-64. 2012
    ..Conditioned medium (CM) taken from microglia stimulated variously (microglial CM; MCM) increased activity of choline acetyltransferase (ChAT), the enzyme responsible for acetylcholine biosynthesis and ..
  61. pmc Identification of retinol binding protein 1 promoter hypermethylation in isocitrate dehydrogenase 1 and 2 mutant gliomas
    Arthur P Chou
    Department of Neurology, David Geffen School of Medicine at the University of California Los Angeles, 90095, USA
    J Natl Cancer Inst 104:1458-69. 2012
    ..tumor suppressor genes whose promoter methylation may contribute to gliomagenesis, we compared methylation profiles of IDH1 mutant (MUT) and IDH1 wild-type (WT) tumors using massively parallel reduced representation bisulfite sequencing.
  62. doi Clinical and molecular findings in Thai patients with isolated methylmalonic acidemia
    Nithiwat Vatanavicharn
    Division of Medical Genetics, Department of Pediatrics, Mahidol University, Bangkok, Thailand
    Mol Genet Metab 106:424-9. 2012
    ..genetically heterogeneous organic acid disorder caused by either deficiency of the enzyme methylmalonyl-CoA mutase (MCM), or a defect in the biosynthesis of its cofactor, adenosyl-cobalamin (AdoCbl)...
  63. ncbi Three alkali-metal-gold-gallium systems. Ternary tunnel structures and some problems with poorly ordered cations
    Volodymyr Smetana
    Ames Laboratory DOE and Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA
    Inorg Chem 51:7711-21. 2012
    ..56(9))Au(2)Ga(2) (I, I4/mcm, a = 8.718(1) Å, c = 4.857(1) Å, Z = 4), Rb(0.56(1))Au(2)Ga(2) (II, I4/mcm, a = 8.950(1) Å, c = 4...
  64. ncbi The IR1152 mutant insulin receptor selectively impairs insulin action in skeletal muscle but not in liver
    M Caruso
    Dipartimento di Biologia e Patologia Cellulare e Molecolare and Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Federico II University of Naples Medical School, Italy
    Diabetes 49:1194-202. 2000
    ..Hepatocytes without the insulin receptor gene and expressing IR1152 (Hep(MUT)) also showed normal insulin suppression of glucose production and full insulin response of glycogen synthase...
  65. doi Modeling a minimal cell
    Michael L Shuler
    Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA
    Methods Mol Biol 881:573-610. 2012
    ..As an initial step toward this aim, a minimal cell model (MCM) has been formulated...
  66. pmc Interactions of the human MCM-BP protein with MCM complex components and Dbf4
    Tin Nguyen
    Department of Molecular Genetics, University of Toronto, Toronto, Canada
    PLoS ONE 7:e35931. 2012
    b>MCM-BP was discovered as a protein that co-purified from human cells with MCM proteins 3 through 7; results which were recapitulated in frogs, yeast and plants...
  67. doi TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group
    Verena I Gaidzik
    Universitatsklinikum Ulm, Ulm, Germany
    J Clin Oncol 30:1350-7. 2012
    ..To date, there is increasing evidence for a functional role of TET2 mutations (TET2(mut)) in AML...
  68. pmc Human tRNA(Lys3)(UUU) is pre-structured by natural modifications for cognate and wobble codon binding through keto-enol tautomerism
    Franck A P Vendeix
    Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695 7622, USA
    J Mol Biol 416:467-85. 2012
    ..The posttranscriptional modifications 5-methoxycarbonylmethyl-2-thiouridine (mcm(5)s(2)U(34)), 2-methylthio-N(6)-threonylcarbamoyladenosine (ms(2)t(6)A(37)), and pseudouridine (Ψ(39)) in the tRNA'..
  69. ncbi Intrinsic catalytic role of mesoporous silica in preferential oxidation of carbon monoxide in excess hydrogen
    Shengjun Huang
    Catalysis Research Center, Hokkaido University, Kita 21 Nishi 10, Kita ku, Sapporo, Hokkaido 001 0021 Japan, Fax 81 11 706 9139
    Chemistry 18:4738-47. 2012
    We have studied the intrinsic catalytic role of MCM-41 mesoporous silica in preferential oxidation of CO in excess H(2) (PROX)...
  70. ncbi Investigation of the physicochemical aspects from natural kaolin to Al-MCM-41 mesoporous materials
    Chunfang Du
    Department of Inorganic Materials, School of Resources Processing and Bioengineering, Central South University, Changsha, China
    J Colloid Interface Sci 369:216-22. 2012
    Aluminum-containing hexagonally ordered mesoporous silica Al-MCM-41 was synthesized by hydrothermal treatment of leached products produced by pre-grinding and subsequent acid leaching of natural kaolin, without addition of silica or ..
  71. pmc ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1
    Hideki Nishitoh
    Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Corporation, Bunkyo ku, Tokyo 113 0033, Japan
    Genes Dev 22:1451-64. 2008
    ..Mutant SOD1 protein (SOD1(mut)) induces motor neuron death, although the molecular mechanism of SOD1(mut)-induced cell death remains ..
  72. doi The influence of carbon sources on recombinant-human- growth-hormone production by Pichia pastoris is dependent on phenotype: a comparison of Muts and Mut+ strains
    Mehmet Ali Orman
    Chemical Engineering Department, Middle East Technical University, 06531 Ankara, Turkey
    Biotechnol Appl Biochem 52:245-55. 2009
    ..pastoris-hGH-Mut(+) and P. pastoris-hGH-Mut(s)) was investigated using batch bioreactors...
  73. doi Key amino acid residues responsible for the differences in substrate specificity of human UDP-glucuronosyltransferase (UGT)1A9 and UGT1A8
    Ryoichi Fujiwara
    Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakumamachi, Kanazawa 920 1192, Japan
    Drug Metab Dispos 37:41-6. 2009
    ..In this study, we constructed expression systems in human embryonic kidney 293 cells for seven mutants (Mut) UGT1A9, Mut 1 (R42Q), Mut 2 (K91M, A92D), Mut 3 (Y106F, G111S, D115G), Mut 4 (N152A), Mut 5 (L173A), Mut 6 (L219F, ..
  74. pmc Functional conservation of beta-hairpin DNA binding domains in the Mcm protein of Methanobacterium thermoautotrophicum and the Mcm5 protein of Saccharomyces cerevisiae
    Ronald P Leon
    Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado, Denver, Colorado 80045, USA
    Genetics 179:1757-68. 2008
    b>Mcm proteins are an important family of evolutionarily conserved helicases required for DNA replication in eukaryotes. The eukaryotic Mcm complex consists of six paralogs that form a heterohexameric ring...
  75. ncbi Molecular basis of methylmalonyl-CoA mutase apoenzyme defect in 40 European patients affected by mut(o) and mut- forms of methylmalonic acidemia: identification of 29 novel mutations in the MUT gene
    Cecile Acquaviva
    Fédération de Génétique, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France
    Hum Mutat 25:167-76. 2005
    Methylmalonyl-CoA mutase (MCM) apoenzyme deficiency is a rare metabolic disease that may result in distinct biochemical phenotypes of methylmalonic acidemia (MMA), namely mut(o) and mut-...
  76. pmc Cleavage of MCM2 licensing protein fosters senescence in human keratinocytes
    Hideki Harada
    Gastroenterology Division and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cell Cycle 7:3534-8. 2008
    In eukaryotic cells, MCM, the minichromosome maintenance proteins, form a heterohexamer during G(1) phase in the cell cycle and constitute a DNA helicase activity at the onset of replication...
  77. doi Adsorption of phenol and o-chlorophenol by mesoporous MCM-41
    Priti A Mangrulkar
    Environmental Materials Unit, National Environmental Engineering Research Institute CSIR, Nagpur 440 020, India
    J Hazard Mater 160:414-21. 2008
    ..Present work deals with the adsorption of phenol (PhOH) and o-chlorophenol (o-CP) on mesoporous MCM-41 material. The effect of surfactant template in MCM-41 on the removal of PhOH and o-CP was investigated...
  78. doi Low-defect, purified, narrowly (n,m)-dispersed single-walled carbon nanotubes grown from cobalt-incorporated MCM-41
    Yuan Chen
    Department of Chemical Engineering, Yale University, New Haven, CT 06520, USA
    ACS Nano 1:327-36. 2007
    ..carbon nanotubes (SWCNTs) with narrow semiconducting (n,m) distribution produced from cobalt-incorporated MCM-41 (Co-MCM-41) in order to obtain bulk low-defect-density nanotubes...
  79. doi Minichromosome maintenance protein expression according to the grade of atypism in actinic keratosis
    Jung Won Shin
    Department of Dermatology, Seoul National University College of Medicine, Korea
    Am J Dermatopathol 32:794-8. 2010
    The minichromosome maintenance (MCM) family is a group of proteins that are key initiation factors for DNA replication and are expressed only in cycling cells...
  80. pmc Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation
    D Sean Froese
    Structural Genomics Consortium, University of Oxford OX3 7DU, United Kingdom
    J Biol Chem 285:38204-13. 2010
    ..Cbl) is essential to the function of two human enzymes, methionine synthase (MS) and methylmalonyl-CoA mutase (MUT)...
  81. ncbi A fraction of MCM 2 proteins remain associated with replication foci during a major part of S phase
    M Masata
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Folia Biol (Praha) 57:3-11. 2011
    The essential role of MCM 2-7 proteins in the initiation of DNA replication in all eukaryotes is well known. Their role in replication elongation is supported by numerous studies, but there is still a knowledge gap in this respect...
  82. doi Silica materials recovered from photonic industrial waste powder: its extraction, modification, characterization and application
    Liang Yi Lin
    Institute of Environmental Engineering, National Chiao Tung University, 1001 University Rd, Hsinchu 300, Taiwan
    J Hazard Mater 192:255-62. 2011
    ..The supernatant is a valuable silicate source for synthesizing mesoporous silica material such as MCM-41...
  83. pmc Roles of Trm9- and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA
    Vibeke Leihne
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    Nucleic Acids Res 39:7688-701. 2011
    ..In eukaryotes, wobble uridines are modified into 5-methoxycarbonylmethyluridine (mcm(5)U), 5-carbamoylmethyluridine (ncm(5)U) or derivatives thereof...
  84. doi Clinical characteristics and gene mutation analysis of methylmalonic aciduria
    Qin Yi
    Department of Pediatrics, Huazhong University of Science and Technology, Wuhan, China
    J Huazhong Univ Sci Technolog Med Sci 31:384-9. 2011
    ..is a common inherited autosomal recessive disorder resulting from defects in the enzyme methylmalonyl CoA mutase (MCM, mut complementation group) or in the synthesis of the MCM cofactor adenosylcobalamin (cbl complementation groups)...
  85. doi Enhancement in adsorption and catalytic activity of enzymes immobilized on phosphorus- and calcium-modified MCM-41
    Kuwahara Yasutaka
    Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University, 2 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Phys Chem B 115:10335-45. 2011
    An oxidative enzyme, horseradish peroxidase (HRP), was immobilized on phosphorus- and/or calcium-modified MCM-41 mesoporous silicas with suitable pore diameters...
  86. doi Study on formulation variables of methotrexate loaded mesoporous MCM-41 nanoparticles for dissolution enhancement
    Nasir Vadia
    Pharmacy Department, M S University of Baroda, Centre of Relevance and Excellence in New Drug Delivery System, Vadodara 390002, Gujarat, India
    Eur J Pharm Sci 45:8-18. 2012
    The aim of this study was to develop methotrexate loaded mesoporous MCM-41 nanoparticles for improved dissolution of methotrexate. The mesoporous MCM-41 nanoparticles act as carrier for drug and increase the solubility of the drug...
  87. doi Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function
    Sabine J Van Dijk
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circ Heart Fail 5:36-46. 2012
    ..We studied if changes in sarcomeric properties in HCM depend on the underlying protein mutation...
  88. pmc Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency
    Jolan E Walter
    Division of Immunology and The Manton Center for Orphan Disease Research, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 207:1541-54. 2010
    ..We have studied a mut/mut mouse model of leaky SCID with a homozygous Rag1 S723C mutation that impairs, but does not abrogate, V(D)J ..
  89. ncbi Synthesis of spherical-like Pt-MCM-41 meso-materials with high catalytic performance for hydrogenation of nitrobenzene
    Huiping Liu
    Key Laboratory for Advanced Materials and Research Institute of Industrial Catalysis, East China University of Science and Technology, Shanghai 200237, People s Republic of China
    J Colloid Interface Sci 346:486-93. 2010
    Spherical-like Pt-MCM-41 meso-materials, including Pt-MCM-41, Pt-Al-MCM-41, and Pt-La-MCM-41, as well as MCM-41, were synthesized by a "one-step" approach with orthosilicate (TEOS) as silica source and cetyltrimethylammonium bromide (..
  90. doi ATP hydrolysis and DNA binding confer thermostability on the MCM helicase
    Nozomi Sakakibara
    University of Maryland Biotechnology Institute, Center for Advanced Research in Biotechnology, Rockville, Maryland 20850, USA
    Biochemistry 48:2330-9. 2009
    The minichromosome maintenance (MCM) helicase is the replicative helicase in archaea. The enzyme utilizes the energy derived from ATP hydrolysis to translocate along one strand of the DNA and unwind the complementary strand...
  91. ncbi [Effect of host MCM-41 on the luminescence properties of Tb(aspirin)3phen]
    Chun Jia Peng
    School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, China
    Guang Pu Xue Yu Guang Pu Fen Xi 28:2498-502. 2008
    Highly ordered mesoporous material MCM-41A(after calcination) and MCM-41B (before calcination) were synthesized in ethylenediamine (EDA) medium at room temperature, and the rare earth complexes Tb(aspirin)3phen which had been heat ..
  92. doi Cardiac myosin-binding protein C mutations and hypertrophic cardiomyopathy: haploinsufficiency, deranged phosphorylation, and cardiomyocyte dysfunction
    Sabine J Van Dijk
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 119:1473-83. 2009
    ..In the present study, we investigated whether protein composition and function of the sarcomere are altered in a homogeneous familial hypertrophic cardiomyopathy patient group with frameshift mutations in MYBPC3 (MYBPC3(mut)).
  93. ncbi Quantification of water and silanol species on various silicas by coupling IR spectroscopy and in-situ thermogravimetry
    Jean Paul Gallas
    , Caen, France
    Langmuir 25:5825-34. 2009
    Five silica samples (four precipitated silicas provided by commercial suppliers and one with the MCM-41 structure) have been studied by infrared spectroscopy and by a homemade thermogravimetry-infrared spectrum (TG-IR) setup...
  94. ncbi [In situ diffuse reflectance FTIR spectroscopy study of CO adsorption on Ni2P/mesoporous molecule sieve catalysts]
    Qian qian Liu
    State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China
    Guang Pu Xue Yu Guang Pu Fen Xi 29:1227-31. 2009
    ..wetness impregnation using nickel nitrate as nickel source, diammonium hydrogen phosphate as phosphorus source, and MCM-41, MCM-48, SBA-15 and SBA-16 as supports, respectively...
  95. doi Kainic acid-activated microglia mediate increased excitability of rat hippocampal neurons in vitro and in vivo: crucial role of interleukin-1beta
    Honghua Zheng
    Department of Brain Research, Division of Anatomy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Neuroimmunomodulation 17:31-8. 2010
    ....
  96. doi Biochemical and genetical analyses of the three mcm genes from the hyperthermophilic archaeon, Thermococcus kodakarensis
    Sonoko Ishino
    Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Hakozaki, Higashi ku, Fukuoka, Japan
    Genes Cells 16:1176-89. 2011
    In eukaryotes, the replicative DNA helicase 'core' is the minichromosome maintenance (Mcm) complex (MCM), forming a heterohexameric complex consisting of six subunits (Mcm2-7)...
  97. pmc Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study
    Guillaume Pare
    Center for Cardiovascular Disease Prevention and the Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Circ Cardiovasc Genet 2:142-50. 2009
    ..Although genetic variants of MTHFR and CBS are known to influence homocysteine concentration, common genetic determinants of homocysteine remain largely unknown...
  98. doi Isomer-dependent adsorption and release of cis- and trans-platin anticancer drugs by mesoporous silica nanoparticles
    Zhimin Tao
    Department of Chemistry, Syracuse University, Syracuse, New York 13244, USA
    Langmuir 26:8914-24. 2010
    ..Two types of particles, MCM-41 and SBA-15, were used, either as just synthesized or after calcination to remove the templates...
  99. pmc Enhancement of neuronal outward delayed rectifier K+ current by human monocyte-derived macrophages
    Dehui Hu
    Neurophysiology Laboratory, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    Glia 57:1492-500. 2009
    ..Bath application of LPS-stimulated MDM-conditioned media (MCM) enhanced neuronal I(K) in a concentration-dependent manner, whereas non-stimulated MCM failed to alter neuronal I(..
  100. ncbi Intracellular localization of hepatic propionyl-CoA carboxylase and methylmalonyl-CoA mutase in humans and normal and vitamin B12 deficient rats
    E P Frenkel
    Br J Haematol 31:501-13. 1975
    ..Vitamin B12 deficiency did not alter the subcellular localization. Finally, a rapid enzymatic assay for methylmalonyl-CoA mutase was described...
  101. ncbi Multiple cross mapping (MCM) markedly improves the localization of a QTL for ethanol-induced activation
    R Hitzemann
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97201 3098, USA
    Genes Brain Behav 1:214-22. 2002
    This study examines the use of multiple cross mapping (MCM) to reduce the interval for an ethanol response QTL on mouse chromosome 1. The phenotype is the acute locomotor response to a 1.5-g/kg i.p. dose of ethanol...

Research Grants93

  1. Chromatin Remodeling by Cdt1: Role in DNA Replication and Tumorigenesis
    MARK GREGORY ALEXANDROW; Fiscal Year: 2010
    ..Cdt1 stimulates the loading of Mini- Chromosome Maintenance (MCM) proteins at preRCs, and Geminin blocks this effect, but the molecular mechanisms behind this are unknown...
  2. Regulation of DNA Replication by MCM Proteins
    Jean Gautier; Fiscal Year: 2010
    ..The mini-chromosome maintenance (MCM) proteins are uniquely required for pre-replicative complex (pre-RC) assembly, origin firing and replisome ..
  3. Regulation of DNA Replication by MCM Proteins
    Jean Gautier; Fiscal Year: 2009
    ..The mini-chromosome maintenance (MCM) proteins are uniquely required for pre-replicative complex (pre-RC) assembly, origin firing and replisome ..
  4. Resolution of Epithelial Cell Hyperplasia
    Yohannes Tesfaigzi; Fiscal Year: 2010
    Epithelial cell hyperplasia in response to an inflammatory response is accompanied by mucous cell metaplasia (MCM), the appearance of mucous cells in airways that are normally devoid of these cells...
  5. Resolution of Epithelial Cell Hyperplasia
    Yohannes Tesfaigzi; Fiscal Year: 2009
    Epithelial cell hyperplasia in response to an inflammatory response is accompanied by mucous cell metaplasia (MCM), the appearance of mucous cells in airways that are normally devoid of these cells...
  6. GENETIC AND MOLECULAR ANALYSIS OF YEAST DNA REPLICATION
    Robert A Sclafani; Fiscal Year: 2010
    ..Three specific aims are proposed. In aim #1, we will elucidate the function and regulation of the MCM DNA helicase by investigating both the N- terminal and C- terminal 2 (Beta)-fingers and the N-terminal region A ..
  7. GENETIC AND MOLECULAR ANALYSIS OF YEAST DNA REPLICATION
    Robert Sclafani; Fiscal Year: 2009
    ..Three specific aims are proposed. In aim #1, we will elucidate the function and regulation of the MCM DNA helicase by investigating both the N- terminal and C- terminal 2 (Beta)-fingers and the N-terminal region A ..
  8. MECHANISMS OF HUMAN PAPILLOMAVIRUS DNA REPLICATION
    LOUISE CHOW; Fiscal Year: 2009
    ..Geminin inhibits Cdt1, which is necessary for loading the cellular replicative helicase MCM complex onto the cellular chromatin...
  9. Regulation of the endo cell cycle in Drosophila
    Terry Orr Weaver; Fiscal Year: 2006
    ..Binding of the Origin Recognition Complex (ORC), the Cdtl/DUP initiator protein, and the MCM hexamer can be visualized directly in the ovarian follicle cells...
  10. MCM PROTEIN FUNCTION DURING EUKARYOTIC DNA REPLICATION
    Stephen Bell; Fiscal Year: 2002
    ..The MCM proteins are a family of six related proteins that play a central role in the replication process in the yeast S...
  11. The Role of the MCM2-7 Complex in the Replication Fork Processivity
    Anthony Schwacha; Fiscal Year: 2010
    ..As one of the few factors essential in both the initiation and elongation phases of DNA replication, defects in MCM activity can compromise the precision of DNA replication in multiple ways...
  12. GENETIC AND MOLECULAR ANALYSIS OF YEAST DNA REPLICATION
    Robert Sclafani; Fiscal Year: 2003
    ..Both protein kinases are hypothesized to phosphorylate the Mcm-complex at origins of DNA replication...
  13. Structural Basis of Large T Helicase Function in SV40 DNA Replication
    Xiaojiang S Chen; Fiscal Year: 2010
    ..the helicase and cellular initiator proteins that consist of multiple initiator factors (such as Orc, Ctd1, Cdc6, MCM in eukaryotes, or DnaA/DnaC/DnaB in prokaryotes) to initiate DNA replication, i.e...
  14. Role of Ddk Kinase in Regulation of DNA Replication
    Wei Jiang; Fiscal Year: 2006
    ..We will examine whether HsCdc7/HsDbf4 phosphorylation of MCM2 affects the formation or conformation of MCM heteromeric complexes and regulates the helicase activity of MCM complex(es)...
  15. RNA-Mediated Silencing: Mechanisms and Biological Roles in Chlamydomonas
    Heriberto Cerutti; Fiscal Year: 2009
    ..1) Molecular characterization of mutants defective in dsRNA-mediated silencing (Mut-68, Mut-70, and Mut-91)...
  16. RNA-Mediated Silencing: Mechanisms and Biological Roles in Chlamydomonas
    Heriberto Cerutti; Fiscal Year: 2007
    ..1) Molecular characterization of mutants defective in dsRNA-mediated silencing (Mut-68, Mut-70, and Mut-91)...
  17. The Role of Osteoactivin in Osteoblast Development and Function
    Fayez F Safadi; Fiscal Year: 2010
    ..During the previous funding period and since the last submission, we established colonies of OA KO and OA mut. mice, and also generated transgenic (Tg) mice that over-express OA in bone. Preliminary data from OA KO, OA mut...
  18. Error Correction in DNA Synthesis: A Biochemical Study
    MYRON FREDRIC GOODMAN; Fiscal Year: 2011
    ..to transfer a molecule of RecA7ATP from its 3'- end to convert inactive pol V into mutagenically active pol V Mut. The properties of pol V Mut (UmuD'2C- RecA7ATP) are regulated through a biochemical cycle of polymerase ..
  19. Regulation of RPA Activity in DNA Repair
    James Borowiec; Fiscal Year: 2009
    ..RPA selectively associates with the replication fork, by characterization of its interaction with the MCM complex...
  20. Regulation of RPA Activity in DNA Repair
    James A Borowiec; Fiscal Year: 2010
    ..RPA selectively associates with the replication fork, by characterization of its interaction with the MCM complex...
  21. Regulation of RPA Activity in DNA Repair
    James A Borowiec; Fiscal Year: 2010
    ..RPA selectively associates with the replication fork, by characterization of its interaction with the MCM complex...
  22. Regulation of mucous cell metaplasia in asthma
    Yohannes Tesfaigzi; Fiscal Year: 2006
    Clinical manifestations of asthma result in part from chronic inflammation that leads to mucous cell metaplasia (MCM), the appearance of mucous cells in peripheral airways that are normally devoid of these cells...
  23. Role of ATM in Radiosensitivity of Gliomas
    Chandan Guha; Fiscal Year: 2004
    ..t.) and U-138 (p53 mut) GBM cells resulting in enhanced radiosensitivity in vitro...
  24. ROLE OF DAF IN THE COMPLEMENT CASCADE AND IN PNH
    MELVIN MEDOF; Fiscal Year: 2004
    ..As an adjunct to these studies, investigations of cancer cells from individuals with Mutator (Mut) phenotypes are designed to determine if GPI-anchored protein deficiency resulting from PIG-A mutation can be ..
  25. ENDOTOXIN INDUCED MUCOUS CELL METAPLASIA
    Yohannes Tesfaigzi; Fiscal Year: 2003
    ..that Bcl-2 expression (a gene that inhibits apoptosis or programmed cell death) plays in mucous cell metaplasia (MCM)...
  26. Replication Licensing in Genome Stability, Cancer and Aging
    STEVEN PRUITT; Fiscal Year: 2009
    ..Alternatively, there is evidence that Mcm proteins, including Mcm2, also function in both the control of gene expression and in an early phase of the DNA ..
  27. Replication Licensing in Genome Stability, Cancer and Aging
    Steven C Pruitt; Fiscal Year: 2010
    ..Alternatively, there is evidence that Mcm proteins, including Mcm2, also function in both the control of gene expression and in an early phase of the DNA ..
  28. REPLICATION OF MAMMALIAN CHROMOSOMES
    JOYCE HAMLIN; Fiscal Year: 2002
    ..5) To determine the distribution of ORC and MCM proteins in the DHFR domain vis-a-vis initiation sites, using a chromatin immunoprecipitation (CHIP) assay.
  29. Defining the importance of CD8+ T Cell Breadth in SIV/HIV protective immunity
    DAVID H OCONNOR; Fiscal Year: 2010
    ..We have discovered that Mauritian cynomolgus macaques (MCM) infected with simian immunodeficiency virus (SIV), a virus that causes the same disease as HIV causes in humans, ..
  30. STRUCTURAL STUDIES OF NUCLEOPROTEIN COMPLEXES
    Edward Egelman; Fiscal Year: 2004
    ..coli DnaB, Simian Virus 40 large T, archaeal MCM and bacteriophage T7 gp4, to study the interaction with DNA, conformational changes that occur during the ATPase ..