Gene Symbol: MURR1
Description: copper metabolism domain containing 1
Alias: C2orf5, MURR1, COMM domain-containing protein 1, copper metabolism (Murr1) domain containing 1, copper metabolism gene MURR1, protein Murr1
Species: human
Products:     MURR1

Top Publications

  1. Maine G, Mao X, Komarck C, Burstein E. COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase. EMBO J. 2007;26:436-47 pubmed
    ..Our data uncover that ubiquitination and degradation of NF-kappaB subunits by this COMMD1-containing ubiquitin ligase is a novel and critical mechanism of regulation of NF-kappaB-mediated transcription. ..
  2. Sarkar B, Roberts E. The puzzle posed by COMMD1, a newly discovered protein binding Cu(II). Metallomics. 2011;3:20-7 pubmed
    ..Additionally, or alternatively, COMMD1 may be an important component of an intracellular system for utilizing Cu(II), or for detecting and detoxifying it. ..
  3. Weiss K, Lozoya J, Tuma S, Gotthardt D, Reichert J, Ehehalt R, et al. Copper-induced translocation of the Wilson disease protein ATP7B independent of Murr1/COMMD1 and Rab7. Am J Pathol. 2008;173:1783-94 pubmed publisher
    ..of ATP7B by both confocal microscopy and RNA interference, testing current models that suggest the involvement of Murr1/COMMD1 and Rab7 in this pathway...
  4. Vonk W, Wijmenga C, Berger R, van De Sluis B, Klomp L. Cu,Zn superoxide dismutase maturation and activity are regulated by COMMD1. J Biol Chem. 2010;285:28991-9000 pubmed publisher
    ..Here, we identify COMMD1 as a novel protein regulating SOD1 activation and associate COMMD1 function with the production of free radicals. ..
  5. Stuehler B, Reichert J, Stremmel W, Schaefer M. Analysis of the human homologue of the canine copper toxicosis gene MURR1 in Wilson disease patients. J Mol Med (Berl). 2004;82:629-34 pubmed
    ..Patients present with a high clinical variability, even when sharing identical mutations. MURR1, the gene causing canine copper toxicosis in Bedlington terriers, maps to chromosome 2 in humans, a region ..
  6. Burstein E, Hoberg J, Wilkinson A, Rumble J, Csomos R, Komarck C, et al. COMMD proteins, a novel family of structural and functional homologs of MURR1. J Biol Chem. 2005;280:22222-32 pubmed
    ..The family is defined by the presence of a conserved and unique motif termed the COMM (copper metabolism gene MURR1) domain, which functions as an interface for protein-protein interactions...
  7. Mao X, Gluck N, Li D, Maine G, Li H, Zaidi I, et al. GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA. Genes Dev. 2009;23:849-61 pubmed publisher
    ..and at least one of the identified ubiquitin ligases is a multimeric complex containing Copper Metabolism Murr1 Domain 1 (COMMD1) and Cul2...
  8. Klomp A, van De Sluis B, Klomp L, Wijmenga C. The ubiquitously expressed MURR1 protein is absent in canine copper toxicosis. J Hepatol. 2003;39:703-9 pubmed
    ..We propose that MURR1, the gene defective in canine CT, has a role in the regulation of copper excretion into bile during copper ..
  9. Ganesh L, Burstein E, Guha Niyogi A, Louder M, Mascola J, Klomp L, et al. The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes. Nature. 2003;426:853-7 pubmed
    ..Here we show that Murr1, a gene product known previously for its involvement in copper regulation, inhibits HIV-1 growth in unstimulated ..

More Information


  1. Burstein E, Ganesh L, Dick R, van De Sluis B, Wilkinson J, Klomp L, et al. A novel role for XIAP in copper homeostasis through regulation of MURR1. EMBO J. 2004;23:244-54 pubmed
    ..XIAP was found to interact with MURR1, a factor recently implicated in copper homeostasis...
  2. Starokadomskyy P, Gluck N, Li H, Chen B, Wallis M, Maine G, et al. CCDC22 deficiency in humans blunts activation of proinflammatory NF-?B signaling. J Clin Invest. 2013;123:2244-56 pubmed publisher
    ..This step requires a factor known as copper metabolism Murr1 domain-containing 1 (COMMD1), the prototype member of a conserved gene family...
  3. Mao X, Gluck N, Chen B, Starokadomskyy P, Li H, Maine G, et al. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. J Biol Chem. 2011;286:32355-65 pubmed publisher
    ..We demonstrate here that COMMD1 (copper metabolism MURR1 domain-containing 1), a factor previously found to promote ubiquitination of various substrates, regulates CRL ..
  4. de Bie P, van De Sluis B, Burstein E, van de Berghe P, Muller P, Berger R, et al. Distinct Wilson's disease mutations in ATP7B are associated with enhanced binding to COMMD1 and reduced stability of ATP7B. Gastroenterology. 2007;133:1316-26 pubmed
    ..Our data implicate COMMD1 in the pathogenesis of WD and indicate that COMMD1 exerts its regulatory role in copper homeostasis through the regulation of ATP7B stability. ..
  5. Maine G, Mao X, Muller P, Komarck C, Klomp L, Burstein E. COMMD1 expression is controlled by critical residues that determine XIAP binding. Biochem J. 2009;417:601-9 pubmed publisher
    COMMD {COMM [copper metabolism Murr1 (mouse U2af1-rs1 region 1)] domain-containing} proteins participate in several cellular processes, ranging from NF-kappaB (nuclear factor kappaB) regulation, copper homoeostasis, sodium transport and ..
  6. Narindrasorasak S, Kulkarni P, Deschamps P, She Y, Sarkar B. Characterization and copper binding properties of human COMMD1 (MURR1). Biochemistry. 2007;46:3116-28 pubmed
    COMMD1 (copper metabolism gene MURR1 (mouse U2af1-rs1 region1) domain) belongs to a family of multifunctional proteins that inhibit nuclear factor NF-kappaB...
  7. Wu Z, Zhao G, Chen W, Wang N, Wan B, Lin M, et al. Mutation analysis of 218 Chinese patients with Wilson disease revealed no correlation between the canine copper toxicosis gene MURR1 and Wilson disease. J Mol Med (Berl). 2006;84:438-42 pubmed
    ..A similar form of copper-associated cirrhosis caused by mutations of the canine copper toxicosis MURR1 gene is also observed in Bedlington terriers...
  8. van De Sluis B, Groot A, Vermeulen J, van der Wall E, van Diest P, Wijmenga C, et al. COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1alpha via HSP90/70. PLoS ONE. 2009;4:e7332 pubmed publisher
    The Copper Metabolism MURR1 Domain containing 1 protein COMMD1 has been associated with copper homeostasis, NF-kappaB signaling, and sodium transport. Recently, we identified COMMD1 as a novel protein in HIF-1 signaling...
  9. Muller T, van De Sluis B, Zhernakova A, van Binsbergen E, Janecke A, Bavdekar A, et al. The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis. J Hepatol. 2003;38:164-8 pubmed
    ..We recently cloned the gene causing copper toxicosis in Bedlington terriers, MURR1, as well as the orthologous human gene on chromosome 2p13-p16...
  10. Thoms H, Loveridge C, Simpson J, Clipson A, Reinhardt K, Dunlop M, et al. Nucleolar targeting of RelA(p65) is regulated by COMMD1-dependent ubiquitination. Cancer Res. 2010;70:139-49 pubmed publisher
    ..These findings have relevance to the design of chemopreventative/anticancer agents that act by targeting RelA to the nucleolar compartment. ..
  11. Materia S, Cater M, Klomp L, Mercer J, La Fontaine S. Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B. J Biol Chem. 2012;287:2485-99 pubmed publisher
    ..Together these data indicate that clusterin and COMMD1 represent alternative and independent systems regulating Cu-ATPase quality control, and consequently contributing to the maintenance of copper homeostasis. ..
  12. Vonk W, de Bie P, Wichers C, van den Berghe P, van der Plaats R, Berger R, et al. The copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression. Cell Mol Life Sci. 2012;69:149-63 pubmed publisher
    ..Together, the presented data might provide a new direction for developing therapies to improve the residual exporting activity of unstable ATP7A mutant proteins, and suggests a potential role for COMMD1 in this process. ..
  13. de Bie P, van De Sluis B, Burstein E, Duran K, Berger R, Duckett C, et al. Characterization of COMMD protein-protein interactions in NF-kappaB signalling. Biochem J. 2006;398:63-71 pubmed
    COMMD [copper metabolism gene MURR1 (mouse U2af1-rs1 region 1) domain] proteins constitute a recently identified family of NF-kappaB (nuclear factor kappaB)-inhibiting proteins, characterized by the presence of the COMM domain...
  14. Biasio W, Chang T, McIntosh C, McDonald F. Identification of Murr1 as a regulator of the human delta epithelial sodium channel. J Biol Chem. 2004;279:5429-34 pubmed
    ..A novel deltaENaC-interacting protein called Murr1 (mouse U2af1-rs1 region) was isolated in the C-terminal domain screen...
  15. van De Sluis B, Rothuizen J, Pearson P, van Oost B, Wijmenga C. Identification of a new copper metabolism gene by positional cloning in a purebred dog population. Hum Mol Genet. 2002;11:165-73 pubmed
    ..While screening genes and expressed sequence tags in this region for mutations we found that exon 2 of the MURR1 gene is deleted in both alleles of all affected Bedlington terriers and in single alleles in obligate carriers...
  16. Burkhead J, Morgan C, Shinde U, Haddock G, Lutsenko S. COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with phosphatidylinositol 4,5-bisphosphate. J Biol Chem. 2009;284:696-707 pubmed publisher
    Copper metabolism Murr1 domain 1 (COMMD1) is a 21-kDa protein involved in copper export from the liver, NF-kappaB signaling, HIV infection, and sodium transport...
  17. Sommerhalter M, Zhang Y, Rosenzweig A. Solution structure of the COMMD1 N-terminal domain. J Mol Biol. 2007;365:715-21 pubmed
    ..These data provide a new foundation for biochemical characterization of COMMD proteins and for probing COMMD1 protein-protein interactions at the molecular level. ..
  18. Coronado V, Bonneville J, Nazer H, Roberts E, Cox D. COMMD1 (MURR1) as a candidate in patients with copper storage disease of undefined etiology. Clin Genet. 2005;68:548-51 pubmed
  19. De Bie P, van de Sluis B, Klomp L, Wijmenga C. The many faces of the copper metabolism protein MURR1/COMMD1. J Hered. 2005;96:803-11 pubmed
    ..Recently, we characterized the COMMD1 (previously MURR1) gene as the defective gene in canine copper toxicosis...
  20. Ke Y, Butt A, Swart M, Liu Y, McDonald F. COMMD1 downregulates the epithelial sodium channel through Nedd4-2. Am J Physiol Renal Physiol. 2010;298:F1445-56 pubmed publisher
    ..Our previous studies demonstrated that Copper Metabolism Murr1 Domain-containing protein 1 (COMMD1; previously known as Murr1), a protein involved in copper metabolism, ..
  21. Tao T, Liu F, Klomp L, Wijmenga C, Gitlin J. The copper toxicosis gene product Murr1 directly interacts with the Wilson disease protein. J Biol Chem. 2003;278:41593-6 pubmed
    ..Recent genetic data have revealed that MURR1, a single copy gene on dog chromosome 10q26, is mutated in this disorder...
  22. Geng H, Wittwer T, Dittrich Breiholz O, Kracht M, Schmitz M. Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination. EMBO Rep. 2009;10:381-6 pubmed publisher
    ..Phosphorylation of p65 at Ser468 leads to ubiquitin/proteasome-dependent removal of chromatin-bound p65, thus contributing to the selective termination of NF-kappaB-dependent gene expression. ..
  23. Drévillon L, Tanguy G, Hinzpeter A, Arous N, de Becdelievre A, Aissat A, et al. COMMD1-mediated ubiquitination regulates CFTR trafficking. PLoS ONE. 2011;6:e18334 pubmed publisher
    ..Thus, increasing COMMD1 expression may provide an approach to simultaneously inhibit ENaC absorption and enhance CFTR trafficking, two major issues in cystic fibrosis. ..
  24. Li H, Koo Y, Mao X, Sifuentes Dominguez L, Morris L, Jia D, et al. Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling. J Cell Biol. 2015;211:605-17 pubmed publisher
    ..Interestingly, among the 10 copper metabolism MURR1 domain containing (COMMD) family members that can associate with the CCC complex, only COMMD9 and its binding ..
  25. Dirksen K, Fieten H. Canine Copper-Associated Hepatitis. Vet Clin North Am Small Anim Pract. 2017;47:631-644 pubmed publisher
    ..In the Labrador retriever, dietary copper intake contributes strongly to the disease phenotype. ..
  26. Jin P, Lv C, Peng S, Cai L, Zhu J, Ma F. Genome-wide organization, evolutionary diversification of the COMMD family genes of amphioxus (Branchiostoma belcheri) with the possible role in innate immunity. Fish Shellfish Immunol. 2018;77:31-39 pubmed publisher
    The COMMD (COpper Metabolism gene MURR1 Domain) gene family with ten members participates in various biological processes, such as the regulation of copper and sodium transport, NF-?B activity and cell cycle progression...
  27. Nantasanti S, Spee B, Kruitwagen H, Chen C, Geijsen N, Oosterhoff L, et al. Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids. Stem Cell Reports. 2015;5:895-907 pubmed publisher
    ..Finally, we demonstrate that successful gene supplementation in hepatic organoids of COMMD1-deficient dogs restores function and can be an effective means to cure copper storage disease. ..
  28. Fedoseienko A, Wijers M, Wolters J, Dekker D, Smit M, Huijkman N, et al. The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking. Circ Res. 2018;122:1648-1660 pubmed publisher
    COMMD (copper metabolism MURR1 domain)-containing proteins are a part of the CCC (COMMD-CCDC22 [coiled-coil domain containing 22]-CCDC93 [coiled-coil domain containing 93]) complex facilitating endosomal trafficking of cell surface ..
  29. Fedoseienko A, Wieringa H, Wisman G, Duiker E, Reyners A, Hofker M, et al. Nuclear COMMD1 Is Associated with Cisplatin Sensitivity in Ovarian Cancer. PLoS ONE. 2016;11:e0165385 pubmed publisher
    Copper metabolism MURR1 domain 1 (COMMD1) protein is a multifunctional protein, and its expression has been correlated with patients' survival in different types of cancer...
  30. Medici V, Weiss K. Genetic and environmental modifiers of Wilson disease. Handb Clin Neurol. 2017;142:35-41 pubmed publisher
    ..Most of the work conducted in this field is in its initial stages but it has the potential to change the diagnosis and treatment of WD. ..
  31. Bartuzi P, Billadeau D, Favier R, Rong S, Dekker D, Fedoseienko A, et al. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nat Commun. 2016;7:10961 pubmed publisher
    ..Altogether, this study provides valuable insights into the mechanisms regulating cholesterol homeostasis and LDLR trafficking. ..
  32. Mu P, Akashi T, Lu F, Kishida S, Kadomatsu K. A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-κB degradation and cell growth suppression in neuroblastoma. Oncogene. 2017;36:5745-5756 pubmed publisher
    ..interaction between filamentous actin (F-actin) and DRR1 in the nucleus, and demonstrated that copper metabolism MURR1 domain-containing 1 (COMMD1) is another binding partner of DRR1...
  33. Astrada S, Gómez Y, Barrera E, Obal G, Pritsch O, Pantano S, et al. Comparative analysis reveals amino acids critical for anticancer activity of peptide CIGB-552. J Pept Sci. 2016;22:711-722 pubmed publisher
    ..Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd. ..
  34. Murata K, Fang C, Terao C, Giannopoulou E, Lee Y, Lee M, et al. Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis. Immunity. 2017;47:66-79.e5 pubmed publisher
    ..These results identify COMMD1 and an E2F-metabolic pathway as key regulators of osteoclastogenic responses under pathological inflammatory conditions and provide a mechanism by which hypoxia augments inflammation and bone destruction. ..
  35. Phillips Krawczak C, Singla A, Starokadomskyy P, Deng Z, Osborne D, Li H, et al. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. Mol Biol Cell. 2015;26:91-103 pubmed publisher
    ..This work provides a mechanistic explanation for the role of COMMD1 in copper homeostasis and uncovers additional genes involved in the regulation of copper transporter recycling. ..
  36. Haywood S, Boursnell M, Loughran M, Trafford J, Isherwood D, Liu X, et al. Copper toxicosis in non-COMMD1 Bedlington terriers is associated with metal transport gene ABCA12. J Trace Elem Med Biol. 2016;35:83-9 pubmed publisher
    ..This region contains the ABCA12 gene which bears a close functional relationship to ATP-ase 7B responsible for Wilson's disease in man. ..
  37. Lappas M. Copper metabolism domain-containing 1 represses the mediators involved in the terminal effector pathways of human labour and delivery. Mol Hum Reprod. 2016;22:299-310 pubmed publisher
    Does Copper Metabolism MURR1 Domain 1 (COMMD1) play a role in regulating the mediators involved in the terminal processes of human labour and delivery? COMMD1 plays a critical role in the termination of nuclear factor-κB (NF-κB) ..
  38. Esposito E, Napolitano G, Pescatore A, Calculli G, Incoronato M, Leonardi A, et al. COMMD7 as a novel NEMO interacting protein involved in the termination of NF-κB signaling. J Cell Physiol. 2016;231:152-61 pubmed publisher
    ..chromatin-bound NF-κB subunit RelA/p65, a process mediated by a protein complex that contains Copper Metabolism Murr1 Domain 1 (COMMD1)...
  39. Vonk W, Kakkar V, Bartuzi P, Jaarsma D, Berger R, Hofker M, et al. The Copper Metabolism MURR1 domain protein 1 (COMMD1) modulates the aggregation of misfolded protein species in a client-specific manner. PLoS ONE. 2014;9:e92408 pubmed publisher
    The Copper Metabolism MURR1 domain protein 1 (COMMD1) is a protein involved in multiple cellular pathways, including copper homeostasis, NF-?B and hypoxia signalling...
  40. Taskinen M, Louhimo R, Koivula S, Chen P, Rantanen V, Holte H, et al. Deregulation of COMMD1 is associated with poor prognosis in diffuse large B-cell lymphoma. PLoS ONE. 2014;9:e91031 pubmed publisher
    ..The results highlight the value of integrated comprehensive analysis to identify prognostic markers and genetic driver events not previously implicated in DLBCL. NCT01502982. ..
  41. Yeh D, Chen Y, Lai C, Liu Y, Lu C, Lo J, et al. Downregulation of COMMD1 by miR-205 promotes a positive feedback loop for amplifying inflammatory- and stemness-associated properties of cancer cells. Cell Death Differ. 2016;23:841-52 pubmed publisher revealed upregulation of NF-κB-regulated pro-inflammatory genes and downregulation of copper metabolism MURR1 domain-containing 1 (COMMD1) during the enrichment for stemness in SAS head and neck squamous-cell carcinoma (..
  42. Chang T, Ke Y, Ly K, McDonald F. COMMD1 regulates the delta epithelial sodium channel (?ENaC) through trafficking and ubiquitination. Biochem Biophys Res Commun. 2011;411:506-11 pubmed publisher
    ..COMMD1 (copper metabolism Murr1 domain 1) was previously found to associate with and downregulate ?ENaC activity...
  43. Taura M, Kudo E, Kariya R, Goto H, Matsuda K, Hattori S, et al. COMMD1/Murr1 reinforces HIV-1 latent infection through IκB-α stabilization. J Virol. 2015;89:2643-58 pubmed publisher
    ..inhibitor of NF-κB, is enhanced by latent HIV-1 infection via induction of the host-derived factor COMMD1/Murr1 in myeloid cells but not in lymphoid cells by using four sets of latently HIV-1-infected cells and the respective ..
  44. O Hara A, Simpson J, Morin P, Loveridge C, Williams A, Novo S, et al. p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-κB subunit. J Cell Sci. 2014;127:3659-65 pubmed publisher
    ..Ubiquitylation, facilitated by COMMD1 (also known as MURR1), acts as a crucial nucleolar-targeting signal for RelA, but how this ubiquitylation is regulated, and how it ..
  45. de Becdelievre A, Rocca J, Aissat A, Drévillon L, Moutereau S, le Gouvello S, et al. COMMD1 modulates noxious inflammation in cystic fibrosis. Int J Biochem Cell Biol. 2013;45:2402-9 pubmed publisher
    ..These data demonstrate the anti-inflammatory properties of COMMD1 in bronchial epithelial cells and open new therapeutic avenues in CF. ..
  46. Taye M, Lee W, Jeon S, Yoon J, Dessie T, Hanotte O, et al. Exploring evidence of positive selection signatures in cattle breeds selected for different traits. Mamm Genome. 2017;28:528-541 pubmed publisher
    ..The genes identified from this study provide an insight into the biological mechanisms and pathways that are important in cattle breeds selected for different traits of economic significance. ..
  47. Smith L, Litman P, Liedtke C. COMMD1 interacts with the COOH terminus of NKCC1 in Calu-3 airway epithelial cells to modulate NKCC1 ubiquitination. Am J Physiol Cell Physiol. 2013;305:C133-46 pubmed publisher
    ..Loss of COMMD1 in Calu-3 cells and in HT29 cells led to reduced ubiquitinated NKCC1. The results indicate a role for COMMD1 in the regulation of NKCC1 membrane expression and ubiquitination. ..
  48. Malek E, Abdel Malek M, Jagannathan S, Vad N, Karns R, Jegga A, et al. Pharmacogenomics and chemical library screens reveal a novel SCFSKP2 inhibitor that overcomes Bortezomib resistance in multiple myeloma. Leukemia. 2017;31:645-653 pubmed publisher
    ..Taken together, the results provide proof of concept for rationally designed drug combinations that incorporate SCFSkp2 inhibitors to treat BTZ resistant disease. ..
  49. Bost M, Piguet Lacroix G, Parant F, Wilson C. Molecular analysis of Wilson patients: direct sequencing and MLPA analysis in the ATP7B gene and Atox1 and COMMD1 gene analysis. J Trace Elem Med Biol. 2012;26:97-101 pubmed publisher
    ..Based on the data of this study, no major role can be attributed to Atox1 and COMMD in the pathophysiology or clinical variation of WD. ..
  50. Nabetani A, Hatada I, Morisaki H, Oshimura M, Mukai T. Mouse U2af1-rs1 is a neomorphic imprinted gene. Mol Cell Biol. 1997;17:789-98 pubmed
    ..An analysis of genome structure of this gene revealed that the whole gene is located in an intron of the Murr1 gene...
  51. Vallespi M, Rodriguez J, Seoane L, Alvarez P, Santana H, Garay H, et al. The first report of cases of pet dogs with naturally occurring cancer treated with the antitumor peptide CIGB-552. Res Vet Sci. 2017;114:502-510 pubmed publisher
    ..Synthetic peptide, COMMD1, Tumor, Dog, CIGB-552. ..
  52. Huang Y, Wu M, Li H. Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1. J Biol Chem. 2008;283:11453-60 pubmed publisher
    ..Together, these data suggest that the ability to promote Lys(63)-mediated polyubiquitination of COMMD1 is a novel property of ARF independent of p53. ..
  53. McDonald F. COMMD1 and ion transport proteins: what is the COMMection? Focus on "COMMD1 interacts with the COOH terminus of NKCC1 in Calu-3 airway epithelial cells to modulate NKCC1 ubiquitination". Am J Physiol Cell Physiol. 2013;305:C129-30 pubmed publisher
  54. Lian M, Zheng X. HSCARG regulates NF-kappaB activation by promoting the ubiquitination of RelA or COMMD1. J Biol Chem. 2009;284:17998-8006 pubmed publisher
    ..In this report, through a yeast two-hybrid screen, HSCARG was found to associate with the copper metabolism gene MURR1 domain containing protein 1 (COMMD1), an inhibitor of NF-kappaB, and negatively regulate COMMD1 by ..
  55. Kwon H, Park S, Hwang H, Sohn I, Kim S. Expression and localization of COMMD1 proteins in human placentas from women with preeclampsia. Yonsei Med J. 2013;54:494-9 pubmed publisher
  56. Zoubeidi A, Ettinger S, Beraldi E, Hadaschik B, Zardan A, Klomp L, et al. Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells. Mol Cancer Res. 2010;8:119-30 pubmed publisher
    ..We propose that elevated levels of sCLU promote prostate cancer cell survival by facilitating degradation of COMMD1 and I-kappaB, thereby activating the canonical NF-kappaB pathway. ..
  57. Gupta A, Chattopadhyay I, Mukherjee S, Sengupta M, Das S, Ray K. A novel COMMD1 mutation Thr174Met associated with elevated urinary copper and signs of enhanced apoptotic cell death in a Wilson Disease patient. Behav Brain Funct. 2010;6:33 pubmed publisher
    ..Two other changes were also identified in the gene. We have examined genotype-phenotype correlation between the detected changes and the atypical presentation of the WD patient. ..
  58. Zhang Z, Joh K, Yatsuki H, Wang Y, Arai Y, Soejima H, et al. Comparative analyses of genomic imprinting and CpG island-methylation in mouse Murr1 and human MURR1 loci revealed a putative imprinting control region in mice. Gene. 2006;366:77-86 pubmed
    Human MURR1 is an orthologue of mouse Murr1 gene, which was previously reported to be imprinted only in adult brain with a maternal allele-predominant expression and to contain another imprinted gene, U2af1-rs1, in the first intron...
  59. Morris J, Nguyen T, Nwadike A, Geels M, Kamp D, Kim B, et al. Soluble Factors Secreted by Endothelial Cells Allow for Productive and Latent HIV-1 Infection in Resting CD4+ T Cells. AIDS Res Hum Retroviruses. 2017;33:110-120 pubmed publisher
    ..Intracellular molecules MURR1, c-Jun N-terminal kinase (JNK), and glucose transporter-1 (GLUT1) were previously shown in blocking HIV infection ..
  60. Riera Romo M. COMMD1: A Multifunctional Regulatory Protein. J Cell Biochem. 2018;119:34-51 pubmed publisher
    ..J. Cell. Biochem. 119: 34-51, 2018. © 2017 Wiley Periodicals, Inc...
  61. Besiktepe N, Kayalar O, Erşen E, Oztay F. The copper dependent-lysyl oxidases contribute to the pathogenesis of pulmonary emphysema in chronic obstructive pulmonary disease patients. J Trace Elem Med Biol. 2017;44:247-255 pubmed publisher
    ..Finally, methods aimed at increasing the protein levels of LOXs, COMMD1 and PTEN might be effective for treating PE. ..