Gene Symbol: MUC7
Description: mucin 7, secreted
Alias: MG2, mucin-7, MUC-7, apo-MG2, mucin 7, salivary, salivary mucin-7
Species: human
Products:     MUC7

Top Publications

  1. Prakobphol A, Thomsson K, Hansson G, Rosen S, Singer M, Phillips N, et al. Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity. Biochemistry. 1998;37:4916-27 pubmed
    Previously we showed that the low-molecular-weight mucin (MG2, encoded by MUC7), a major component of human submandibular/sublingual saliva, is a bacterial receptor that coats the tooth surface...
  2. Mall A, Habte H, Mthembu Y, Peacocke J, de Beer C. Mucus and Mucins: do they have a role in the inhibition of the human immunodeficiency virus?. Virol J. 2017;14:192 pubmed publisher
    ..Crude saliva and its purified mucins, MUC5B and MUC7, and the purified mucins from breast milk, MUC1 and MUC4 and pregnancy plug cervical mucus (MUC2, MUC5AC, MUC5B and ..
  3. Liu X, Lyu J, An Y. [Explore objective clinical variables for detecting delirium in ICU patients: a prospective case-control study]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:347-352 pubmed publisher
    ..003), chloride concentration [Cl- (mmol/L): 114.66±4.32 vs. 111.90±3.08, P = 0.019], magnesium concentration [Mg2+ (mmol/L): 0.60±0.10 vs. 0.54±0.06, P = 0.035] and blood osmolality [mmol/L: 290.10 (284.15, 306...
  4. El Ayed M, Kadri S, Smine S, Elkahoui S, Limam F, Aouani E. Protective effects of grape seed and skin extract against high-fat-diet-induced lipotoxicity in rat lung. Lipids Health Dis. 2017;16:174 pubmed publisher
    ..We also analyzed transition metals (Ca2+, Mg2+, Zn2+ and iron) and lung free fatty acids using gas chromatography coupled to mass spectrometry (GC-MS)...
  5. Kuan C, Yee Y, See Too W, Few L. Ets and GATA transcription factors play a critical role in PMA-mediated repression of the ckβ promoter via the protein kinase C signaling pathway. PLoS ONE. 2014;9:e113485 pubmed publisher
    ..It catalyzes the phosphorylation of choline to phosphorylcholine in the presence of ATP and Mg2+ during the biosynthesis of phosphatidylcholine, the major phospholipid in eukaryotic cell membranes...
  6. Fan J, Zhang Y, Liu W, Zhu X, Xu D, Zhao J, et al. Long Non-Coding RNA MALAT1 Protects Human Osteoblasts from Dexamethasone-Induced Injury via Activation of PPM1E-AMPK Signaling. Cell Physiol Biochem. 2018;51:31-45 pubmed publisher
    ..Transfection with LV-MALAT1 downregulated Ppm1e (protein phosphatase, Mg2+/ Mn2+-dependent 1e) expression to activate AMPK signaling...
  7. Li D, Ren J, Zhang T, Liu R, Wu L, Du Q, et al. Anti-fatigue effects of small-molecule oligopeptides isolated from Panax quinquefolium L. in mice. Food Funct. 2018;9:4266-4273 pubmed publisher
    ..Notably, QOPs enhanced the activity of succinate dehydrogenase (SDH), Na+-K+-ATPase, and Ca2+-Mg2+-ATPase and increased the mRNA expression of nuclear respiratory factor 1 (NRF-1) and mitochondrial transcription ..
  8. Menè P, Punzo G, Pirozzi N. TRP channels as therapeutic targets in kidney disease and hypertension. Curr Top Med Chem. 2013;13:386-97 pubmed
    ..Similar to Ca2+, Mg2+ transcellular reabsorption occurs in the distal convoluted tubule via apical TRPM6/TRPM7 channels...
  9. Long X, Wu X, Zhao L, Ye H, Cheng Y, Zeng C. Effects of salinity on gonadal development, osmoregulation and metabolism of adult male Chinese mitten crab, Eriocheir sinensis. PLoS ONE. 2017;12:e0179036 pubmed publisher
    ..The results showed that elevating salinity promote gonadal development, increase hemolymph osmolality and K+ and Mg2+ concentrations (P < 0.05)...

More Information

Publications143 found, 100 shown here

  1. Kämpf M, Braun M, Sirena D, Ihssen J, Thöny Meyer L, Ren Q. In vivo production of a novel glycoconjugate vaccine against Shigella flexneri 2a in recombinant Escherichia coli: identification of stimulating factors for in vivo glycosylation. Microb Cell Fact. 2015;14:12 pubmed publisher
    ..1-fold. The optimum concentration of Mg2+ ions for N-glycan transfer was determined to be 10 mM...
  2. Mootapally C, Nathani N, Patel A, Jakhesara S, Joshi C. Mining of Ruminant Microbial Phytase (RPHY1) from Metagenomic Data of Mehsani Buffalo Breed: Identification, Gene Cloning, and Characterization. J Mol Microbiol Biotechnol. 2016;26:252-60 pubmed publisher
    ..Significant inhibition of RPHY1 activity was observed for Mg2+ and K+ metal ions, while Ca2+, Mn2+, and Na+ slightly inhibited enzyme activity...
  3. Wang L, Li J, Zhao X, Qian C, Wei G, Zhu B, et al. Expression and characterization of a lipase-related protein in the malpighian tubules of the Chinese oak silkworm, Antheraea pernyi. Bull Entomol Res. 2016;106:615-23 pubmed publisher
    ..0, respectively. ApLRP activity was stimulated in the presence of Mg2+, Na+, Ca2+ and b-mercaptoethanol; while Zn2+, Cu2+ and Fe3+ inhibited its activity...
  4. Antonyuk R, Lutsyk A, Antonyuk V. Lectin purification from carp roe (Cyprinus carpio L.), investigation of its carbohydrate specificity and application in histochemistry. Rom J Morphol Embryol. 2016;57:985-994 pubmed
    ..For the lectin activity, divalent metal ions (Ca2+ and Mg2+) were not necessary...
  5. Solovieva E, Fedotov A, Mamonov V, Komlev V, Panteleyev A. Fibrinogen-modified sodium alginate as a scaffold material for skin tissue engineering. Biomed Mater. 2017;: pubmed publisher
    ..The slow rates of scaffold biodegradation were achieved by using Ca2+ and Mg2+ cations as cross-linking agents...
  6. Lin L, Dai F, Chen Z, Cai L. In Vitro Treatment with 2-APB Inhibits the Inflammation in Nasal Polyps. Otolaryngol Head Neck Surg. 2015;153:461-7 pubmed publisher
    ..dermatophagoides pteronyssinus (DP)-specific immunoglobulin E (sIgE) as well as mucins (MUCs) including MUC5B and MUC7 in cultures were analyzed with ELISA and real-time RT-PCR...
  7. Takashina Y, Manabe A, Hasegawa H, Matsunaga T, Endo S, Ikari A. Sodium Citrate Increases Expression and Flux of Mg2+ Transport Carriers Mediated by Activation of MEK/ERK/c-Fos Pathway in Renal Tubular Epithelial Cells. Nutrients. 2018;10: pubmed publisher
    ..These results suggest that SC increases TRPM6 expression and Mg2+ influx mediated by the activation of NADPH oxidase and an EGFR/ERK/c-Fos pathway in the renal tubules. ..
  8. Lee M, Yang D, Kim S. Alterations of Mg2+ After Hemorrhagic Shock. Biol Trace Elem Res. 2017;180:120-126 pubmed publisher
    ..In conclusion, hemorrhagic shock induced an increase in both blood-free Mg2+ and tMg, resulted from Mg2+ efflux from metabolic damaged cell with acidosis and ATP depletion. ..
  9. Chekhun V, Todor I, Lukianova N, Horbyk D, Lozovskaya Y, Burlaka A, et al. Influence of ferromagnetic nanocomposite (Ferroplat) on human breast cancer cells of different malignancy degrees: pro/antioxidant balance and energy metabolism. Exp Oncol. 2018;40:268-274 pubmed
    ..In addition, the effect of FrP caused a decrease in the levels of Mg2+ and lactate in MCF-7 and T47D cells by 21-29% and 14-24%, respectively, whereas in MDA-MB-231, MDA-MB-468, MCF-7/..
  10. Sun L, Zhao T, Ju T, Wang X, Li X, Wang L, et al. A Combination of Intravenous Genistein Plus Mg2+ Enhances Antihypertensive Effects in SHR by Endothelial Protection and BKCa Channel Inhibition. Am J Hypertens. 2015;28:1114-20 pubmed publisher
    ..These results suggest a novel and feasible protocol for the prevention and treatment of hypertension and related cardio- and cerebro-vascular diseases. ..
  11. Lv X, Guo F, Xu X, Chen Z, Sun X, Min D, et al. Abnormal alterations in the Ca²⁺/CaV1.2/calmodulin/caMKII signaling pathway in a tremor rat model and in cultured hippocampal neurons exposed to Mg²⁺-free solution. Mol Med Rep. 2015;12:6663-71 pubmed publisher
    ..2/CaM/CaMKII pathway in TRMs and in cultured hippocampal neurons exposed to Mg2+‑free solution. The expression levels of CaV1...
  12. Anunciado Koza R, Zhang J, Ukropec J, Bajpeyi S, Koza R, Rogers R, et al. Inactivation of the mitochondrial carrier SLC25A25 (ATP-Mg2+/Pi transporter) reduces physical endurance and metabolic efficiency in mice. J Biol Chem. 2011;286:11659-71 pubmed publisher
    ..However, in the absence of UCP1-based thermogenesis, induction of Slc25a25 in mice with an intact gene may contribute to an alternative thermogenic pathway for the maintenance of body temperature during cold stress. ..
  13. Xiao Z, Peng J, Wu L, Arafat A, Yin F. The effect of IL-1β on synaptophysin expression and electrophysiology of hippocampal neurons through the PI3K/Akt/mTOR signaling pathway in a rat model of mesial temporal lobe epilepsy. Neurol Res. 2017;39:640-648 pubmed publisher
    ..Then, we cultured primary neuron and established a neuronal epilepsy model using Mg2+-free media...
  14. Belon C, Soscia C, Bernut A, Laubier A, Bleves S, Blanc Potard A. A Macrophage Subversion Factor Is Shared by Intracellular and Extracellular Pathogens. PLoS Pathog. 2015;11:e1004969 pubmed publisher
    ..Moreover, we demonstrate that P. aeruginosa MgtC is required for optimal growth in Mg2+ deprived medium, a property shared by MgtC factors from intracellular pathogens and, under Mg2+ limitation, P...
  15. Ma J, Rubin B, Voynow J. Mucins, Mucus, and Goblet Cells. Chest. 2018;154:169-176 pubmed publisher
    ..There are three classes of mucins in the airways: those that are secreted but do not polymerize (MUC7), those that are secreted and polymerize to form gels (MUC5AC, MUC5B), and those that have transmembrane domains ..
  16. Boldinova E, Stojkovič G, Khairullin R, Wanrooij S, Makarova A. Optimization of the expression, purification and polymerase activity reaction conditions of recombinant human PrimPol. PLoS ONE. 2017;12:e0184489 pubmed publisher
    ..We demonstrate that the reaction buffer with pH 6-6.5, low salt concentrations and 3 mM Mg2+ or 0.3-3 mM Mn2+ cofactor ions supports the highest DNA polymerase activity of human PrimPol in vitro...
  17. Klar J, Piontek J, Milatz S, Tariq M, Jameel M, Breiderhoff T, et al. Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage. PLoS Genet. 2017;13:e1006897 pubmed publisher
    ..Furthermore, affected individuals present with Mg2+ retention, secondary hyperparathyroidism and mild kidney failure that suggest a disturbed reabsorption of cations ..
  18. Zhang L, Ma J, Liu H. Protective effect of ischemic postconditioning against ischemia reperfusion-induced myocardium oxidative injury in IR rats. Molecules. 2012;17:3805-17 pubmed publisher
    ..could still decrease myocardium malondialdehyde (MDA) level, and increased myocardium Na+-K+-ATPase, Ca2+-Mg2+-ATPase, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) ..
  19. Schaffer S, Shimada Takaura K, Jong C, Ito T, Takahashi K. Impaired energy metabolism of the taurine‑deficient heart. Amino Acids. 2016;48:549-58 pubmed publisher the NADH/NAD+ ratio and by decreased availability of pyruvate for oxidation to acetyl CoA and changes in [Mg2+]i...
  20. Egerbacher M, Wolfesberger B, Walter I, Seirberl G. Integrins mediate the effects of quinolones and magnesium deficiency on cultured rat chondrocytes. Eur J Cell Biol. 1999;78:391-7 pubmed
    ..which form chelate complexes with divalent cations) on chondrocytes in vitro in order to assess the role of Mg2+ ions in integrin function and to establish cellular changes mediated via integrin signal transduction...
  21. Cao R, Meng Z, Liu T, Wang G, Qian G, Cao T, et al. Decreased TRPM7 inhibits activities and induces apoptosis of bladder cancer cells via ERK1/2 pathway. Oncotarget. 2016;7:72941-72960 pubmed publisher
    Transient receptor potential melastatin 7 (TRPM7) functions as a Mg2+/Ca2+-permeable channel fused with a kinase domain and regulates various physical processes and diseases...
  22. Griffin M, Letson H, Dobson G. Small-Volume Adenosine, Lidocaine, and Mg2+ 4-Hour Infusion Leads to 88% Survival after 6 Days of Experimental Sepsis in the Rat without Antibiotics. Clin Vaccine Immunol. 2016;23:863-872 pubmed
    ..Late death (day 5) was associated with a massive neutrophil inflammatory storm, increased lung injury, and persistent ischemia. Possible mechanisms of ALM protection are discussed. ..
  23. Pondugula S, Flannery P, Apte U, Babu J, Geetha T, Rege S, et al. Mg2+/Mn2+-dependent phosphatase 1A is involved in regulating pregnane X receptor-mediated cytochrome p450 3A4 gene expression. Drug Metab Dispos. 2015;43:385-91 pubmed publisher
    ..These results implicate a novel role for PPM1A in regulating hPXR-mediated CYP3A4 expression in hepatocytes and may explain a mechanism for CYP3A repression in regenerating livers. ..
  24. Contreras M, Sengupta T, Sheikh F, Aubourg P, Singh I. Topology of ATP-binding domain of adrenoleukodystrophy gene product in peroxisomes. Arch Biochem Biophys. 1996;334:369-79 pubmed
    ..this polypeptide on polyvinylidene difluoride membrane was able to bind [gamma-32P]ATP in vitro in the presence of Mg2+...
  25. Granot G, Morgenstern Y, Khan A, Rapp Y, Pesok A, Nevo E, et al. Internucleosomal DNA fragmentation in wild emmer wheat is catalyzed by S1-type endonucleases translocated to the nucleus upon induction of cell death. Biochim Biophys Acta. 2015;1849:239-46 pubmed publisher
    ..Here, we characterized a Ca2+/Mg2+-dependent S1-type endonuclease activity in leaves of wild emmer wheat (Triticum dicoccoides Köern...
  26. Chaudhury N, Shirlaw P, Pramanik R, Carpenter G, Proctor G. Changes in Saliva Rheological Properties and Mucin Glycosylation in Dry Mouth. J Dent Res. 2015;94:1660-7 pubmed publisher
    ..8%) had a saliva secretion rate above the gland dysfunction cutoff of 0.1 mL/min. Mucin (MUC5B and MUC7) concentrations were generally similar or higher in patients...
  27. Qin X, Zhang J, Zhang X, Yang Y. Induction, purification and characterization of a novel manganese peroxidase from Irpex lacteus CD2 and its application in the decolorization of different types of dye. PLoS ONE. 2014;9:e113282 pubmed publisher
    ..CD2-MnP had a strong capability for tolerating different metal ions such as Ca2+, Cd2+, Co2+, Mg2+, Ni2+ and Zn2+ as well as organic solvents such as methanol, ethanol, DMSO, ethylene glycol, isopropyl alcohol, ..
  28. Behera S, Praharaj A, Dehury B, Negi S. Exploring the role and diversity of mucins in health and disease with special insight into non-communicable diseases. Glycoconj J. 2015;32:575-613 pubmed publisher
    ..In human it is only MUC1 and MUC7 that have mucin domains with less than 40% serine and threonine which in turn could reduce number of PTS domains...
  29. Chebotareva N, Eronina T, Sluchanko N, Kurganov B. Effect of Ca2+ and Mg2+ ions on oligomeric state and chaperone-like activity of αB-crystallin in crowded media. Int J Biol Macromol. 2015;76:86-93 pubmed publisher
  30. Zhang L, Ma H, Chen T, Pen J, Yu S, Zhao X. Morphological and physiological responses of cotton (Gossypium hirsutum L.) plants to salinity. PLoS ONE. 2014;9:e112807 pubmed publisher
    ..addition, salinity caused ion imbalance in plants as shown by higher Na+ and Cl- contents and lower K+, Ca2+, and Mg2+ concentrations. Ion imbalance was more pronounced in CCRI-79 than in Simian3...
  31. Sorkhabi Abdolmaleki S, Zibaee A, Hoda H, Fazeli Dinan M. Purification and characterization of midgut α-amylase in a predatory bug, Andralus spinidens. J Insect Sci. 2014;14:65 pubmed publisher
    ..3 kDa. The enzyme had optimal pH and temperature of 7 and 45°C, respectively. Na+, Mn+, Mg2+, and Zn2+ significantly decreased activity of the purified α-amylase, but some concentrations of K+, Ca2+, and ..
  32. Huang J, Wu Y, Huang Q, Li S, Ye J, Wei X, et al. Expression level and distribution of HMGB1 in Sombati's cell model and kainic acid-induced epilepsy model. Eur Rev Med Pharmacol Sci. 2015;19:2928-33 pubmed
    ..Dissociated hippocampal neurons from neonatal SD rats and cultured those for 9 days, then changed medium to Mg2+-free medium for 3 hours to induce Sombati's cell model...
  33. Yang Y, Huang S, Wang J, Jan G, Jeantet R, Chen X. Mg2+ improves the thermotolerance of probiotic Lactobacillus rhamnosus GG, Lactobacillus casei Zhang and Lactobacillus plantarum P-8. Lett Appl Microbiol. 2017;64:283-288 pubmed publisher
    ..A novel strategy may be available in the near future by employing magnesium salts as protective agents of probiotics during manufacturing process. ..
  34. Cho Y, Kim H, Kim W, Chung S, Kim Y, Cho I, et al. Trafficking patterns of NMDA and GABAA receptors in a Mg2+-free cultured hippocampal neuron model of status epilepticus. Epilepsy Res. 2017;136:143-148 pubmed publisher
    ..These results suggest that targeting of surface NMDAR could be a promising method in controlling benzodiazepine-resistant SE. ..
  35. Treadwell R, De Moliner F, Subirós Funosas R, Hurd T, Knox K, Vendrell M. A fluorescent activatable probe for imaging intracellular Mg2+ . Org Biomol Chem. 2018;16:239-244 pubmed publisher
    ..Fluorescence amplification of the probe is observed upon detection of physiological concentrations of Mg2+ due to reduced rotation of the fluorophore and effective chelation by a quinolizine-based core. ..
  36. Yano N, Muramoto K, Shimada A, Takemura S, Baba J, Fujisawa H, et al. The Mg2+-containing Water Cluster of Mammalian Cytochrome c Oxidase Collects Four Pumping Proton Equivalents in Each Catalytic Cycle. J Biol Chem. 2016;291:23882-23894 pubmed
    ..Thus, these x-ray structures indicate that the Mg2+-containing water cluster is the crucial structural element providing the effective proton pumping in bovine CcO. ..
  37. Kaviani S, Izadyar M, Housaindokht M. A DFT study on the complex formation between desferrithiocin and metal ions (Mg2+, Al3+, Ca2+, Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Zn2+). Comput Biol Chem. 2017;67:114-121 pubmed publisher
    ..Finally, some probable correlations between the complexation behavior and quantum chemistry descriptors have been analyzed. ..
  38. Li Z, Zhu Y, Zhou X, Zhuo B, Wang X. microRNA-135b expression silences Ppm1e to provoke AMPK activation and inhibit osteoblastoma cell proliferation. Oncotarget. 2017;8:26424-26433 pubmed publisher
    ..Here, we aim to provoke AMPK activation via microRNA silencing its phosphatase Ppm1e (protein phosphatase Mg2+/Mn2+-dependent 1e)...
  39. Permyakov E, Permyakov S, Breydo L, Redwan E, Almehdar H, Uversky V. Disorder in Milk Proteins: ?-Lactalbumin. Part C. Peculiarities of Metal Binding. Curr Protein Pept Sci. 2016;17:735-745 pubmed
    ..The binding of Mg2+, Na+, and K+ to the Ca2+ site increases ?-lactalbumin stability against action of heat and various denaturing ..
  40. Meissner G, de Resende Lara P, Scott L, Braz A, Chaves Moreira D, Matsubara F, et al. Molecular cloning and in silico characterization of knottin peptide, U2-SCRTX-Lit2, from brown spider (Loxosceles intermedia) venom glands. J Mol Model. 2016;22:196 pubmed publisher
    ..The sequence of U2-SCRTX-Lit2 obtained from the transcriptome is similar to that of μ-Hexatoxin-Mg2, a peptide that inhibits the insect Nav channel...
  41. Pontes M, Yeom J, Groisman E. Reducing Ribosome Biosynthesis Promotes Translation during Low Mg2+ Stress. Mol Cell. 2016;64:480-492 pubmed publisher
    ..Our findings establish a paradigm whereby cells reduce the amounts of translating ribosomes to carry out protein synthesis. ..
  42. Milatz S, Himmerkus N, Wulfmeyer V, Drewell H, Mutig K, Hou J, et al. Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na+ and Mg2+ transport. Proc Natl Acad Sci U S A. 2017;114:E219-E227 pubmed publisher
  43. Saramago M, Peregrina A, Robledo M, Matos R, Hilker R, Serrania J, et al. Sinorhizobium meliloti YbeY is an endoribonuclease with unprecedented catalytic features, acting as silencing enzyme in riboregulation. Nucleic Acids Res. 2017;45:1371-1391 pubmed publisher
    ..SmYbeY-mediated catalysis was supported by the divalent metal ions Mg2+, Mn2+ and Ca2+, which influenced in a different manner cleavage efficiency and reactivity patterns, with Ca2+ ..
  44. Beniaminov A, Dezhenkova L, Mamaeva O, Shchyolkina A, Tevyashova A, Kaluzhny D, et al. Divalent cations are dispensable for binding to DNA of a novel positively charged olivomycin A derivative. PLoS ONE. 2018;13:e0191923 pubmed publisher
    ..We herein report that compound 3 is able to form stable complexes with DNA in the absence of Mg2+, in striking contrast to 1 whose binding to the DNA absolutely requires Mg2+...
  45. Troxler R, Iontcheva I, Oppenheim F, Nunes D, Offner G. Molecular characterization of a major high molecular weight mucin from human sublingual gland. Glycobiology. 1997;7:965-73 pubmed
    ..MG2 is the product of the MUC7 gene, whereas the gene for MG1 has not been identified...
  46. Sohn Y, Lee S, Lee K, Ku B, Shin H, Cha S, et al. Identification of a Highly Conserved Hypothetical Protein TON_0340 as a Probable Manganese-Dependent Phosphatase. PLoS ONE. 2016;11:e0167549 pubmed publisher
    ..b>Mg2+ binds to TON_0340 less tightly and activates the phosphatase activity less efficiently than Mn2+...
  47. Vocke F, Weisschuh N, Marino V, Malfatti S, Jacobson S, Reiff C, et al. Dysfunction of cGMP signalling in photoreceptors by a macular dystrophy-related mutation in the calcium sensor GCAP1. Hum Mol Genet. 2017;26:133-144 pubmed publisher
    ..we expressed and purified the mutant protein and measured key parameters of its activating properties, its Ca2+/Mg2+-binding, and its Ca2+-induced conformational changes in comparison to the wildtype protein...
  48. Machado C, Pimentel N, Golynsk A, Ferreira A, Vieira H, Partelli F. Genetic diversity among 16 genotypes of Coffea arabica in the Brazilian cerrado. Genet Mol Res. 2017;16: pubmed publisher
    ..The first three major components accounted for 81.77% of the total variance. The genotype H-419-3-4-4-13(C-241) of low size was the most divergent, followed by Catucaí 2 SL and Catiguá MG2, according to the main components.
  49. Carrara S, Cangi M, Arcidiacono P, Perri F, Petrone M, Mezzi G, et al. Mucin expression pattern in pancreatic diseases: findings from EUS-guided fine-needle aspiration biopsies. Am J Gastroenterol. 2011;106:1359-63 pubmed publisher
    ..of MUCs by reverse transcription-PCR with primers specific for the MUC1, MUC2, MUC3, MUC4, MUC5A, MUC5B, MUC6, and MUC7 genes. RNA extraction was successful in 81% of the biopsies...
  50. Yamanaka R, Shindo Y, Karube T, Hotta K, Suzuki K, Oka K. Neural depolarization triggers Mg2+ influx in rat hippocampal neurons. Neuroscience. 2015;310:731-41 pubmed publisher
    ..Overall, activity-dependent [Mg(2+)]i increase results from Mg(2+) influx through 2-APB-sensitive channels in rat hippocampal neurons. ..
  51. del Mundo I, Zewail Foote M, Kerwin S, Vasquez K. Alternative DNA structure formation in the mutagenic human c-MYC promoter. Nucleic Acids Res. 2017;45:4929-4943 pubmed publisher
    ..We characterized the structures formed in the presence of G4-DNA-stabilizing K+ ions or H-DNA-stabilizing Mg2+ ions using multiple techniques...
  52. Boroda S, Takkellapati S, Lawrence R, Entwisle S, Pearson J, Granade M, et al. The phosphatidic acid-binding, polybasic domain is responsible for the differences in the phosphoregulation of lipins 1 and 3. J Biol Chem. 2017;292:20481-20493 pubmed publisher
    ..These results indicate a mechanism for the observed differences in lipin phosphoregulation in vitro. ..
  53. Hosy E, Derand R, Revilloud J, Vivaudou M. Remodelling of the SUR-Kir6.2 interface of the KATP channel upon ATP binding revealed by the conformational blocker rhodamine 123. J Physiol. 2007;582:27-39 pubmed direct binding of ATP to SUR and did not entail hydrolysis because it was not mimicked by AMP, did not require Mg2+ and was reduced by mutations in the nucleotide-binding domains of SUR...
  54. Watson A, Ngor W, Gordish Dressman H, Freishtat R, Rose M. MUC7 polymorphisms are associated with a decreased risk of a diagnosis of asthma in an African American population. J Investig Med. 2009;57:882-6 pubmed publisher
    ..b>MUC7 typically encodes for 6 VNTRs, each with 23 amino acids...
  55. Gomes G, Assis M, Fonseca J, de Souza P, Zenóbio E, Oliveira D, et al. Genetic polymorphism of MUC7 in individuals with aggressive or chronic periodontitis. J Oral Sci. 2011;53:445-9 pubmed
    ..with periodontitis exhibit differential expression of mucin-glycoprotein-2 (MG2), a protein encoded by the MUC7 gene...
  56. Veklich T, Mazur I, Kosterin S. [Mg2+, ATP-dependent plasma membrane calcium pump of smooth muscle cells. I. Structural organization and properties]. Ukr Biochem J. 2015;87:5-20 pubmed
    ..One of key proteins which control Ca2+ concentration in cytoplasm is Mg2+, ATP-dependent plasma membrane calcium pump...
  57. Lerche M, Sandhu H, Flöckner L, Högbom M, Rapp M. Structure and Cooperativity of the Cytosolic Domain of the CorA Mg2+ Channel from Escherichia coli. Structure. 2017;25:1175-1186.e4 pubmed publisher
    ..Biochemical data on the isolated cytoplasmic domain and full-length protein suggests that gating of the CorA channel is governed cooperatively. ..
  58. Tanaka A, Tanabe K, Morita M, Kurisu M, Kasiwayama Y, Matsuo M, et al. ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and adrenoleukodystrophy protein (ABCD1). J Biol Chem. 2002;277:40142-7 pubmed
    ..and 8-azido-[gamma-32P]ATP when peroxisomes were incubated with these nucleotides at 37 degrees C in the absence Mg2+ and exposed to UV light without removing unbound nucleotides...
  59. Gulik P. On the Origin of Sequence. Life (Basel). 2015;5:1629-37 pubmed publisher
    ..the production of oligopeptides with a high aspartic acid content, which protected small RNA molecules by binding Mg2+ ions...
  60. Skilandat M, Rowinska Zyrek M, Sigel R. Secondary structure confirmation and localization of Mg2+ ions in the mammalian CPEB3 ribozyme. RNA. 2016;22:750-63 pubmed publisher
  61. Cegłowski M, Balcerzak P, Frański R, Schroeder G. Determination of conditional stability constants for phytic acid complexes with Mg2+, Ca2+ and Zn2+ ions using electrospray ionization mass spectrometry. Eur J Mass Spectrom (Chichester). 2016;22:245-252 pubmed
    ..The values obtained are in agreement with the literature data. The method applied permitted a fast and simple determination of conditional stability constants by measuring the response of the ionized coordination complexes. ..
  62. Zebardast Roodi F, Aminzadeh S, Farrokhi N, Karkhane A, Haghbeen K. Cohnella amylopullulanases: Biochemical characterization of two recombinant thermophilic enzymes. PLoS ONE. 2017;12:e0175013 pubmed publisher
    ..Enzyme activities for both proteins were improved in the availability of Mn2+, Ba2+, Ca2+, and Mg2+ and reduced in the presence of Fe2+, Li2+, Na2+, Triton X100 and urea...
  63. Gautam A, Panse Y, Ghosh P, Reza M, Mullick J, Sahu A. Mutational analysis of Kaposica reveals that bridging of MG2 and CUB domains of target protein is crucial for the cofactor activity of RCA proteins. Proc Natl Acad Sci U S A. 2015;112:12794-9 pubmed publisher
    ..the model suggested that the C3b-interacting residues bridge the CUB (complement C1r-C1s, Uegf, Bmp1) and MG2 (macroglobulin-2) domains of C3b...
  64. Lin Q, Gruskos J, Buccella D. Bright, red emitting fluorescent sensor for intracellular imaging of Mg2+?. Org Biomol Chem. 2016;14:11381-11388 pubmed
  65. Ralec C, Henry E, Lemor M, Killelea T, Henneke G. Calcium-driven DNA synthesis by a high-fidelity DNA polymerase. Nucleic Acids Res. 2017;: pubmed publisher
    Divalent metal ions, usually Mg2+, are required for both DNA synthesis and proofreading functions by DNA polymerases (DNA Pol)...
  66. Dudev T, Cheshmedzhieva D, Doudeva L. Competition between abiogenic Al3+ and native Mg2+, Fe2+ and Zn2+ ions in protein binding sites: implications for aluminum toxicity. J Mol Model. 2018;24:55 pubmed publisher
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    ..Hydrodynamic properties of zGCAPs are more influenced by Ca(2+) than by Mg(2+), although to a different extent for each zGCAP. Posttranslational modification and competing ion-binding can tailor the properties of similar Ca(2+)-sensors. ..
  68. Motin V, Yasnetsov V. Effect of NMDA, a Specific Agonist to NMDA Receptor Complex, on Rat Hippocampus. Bull Exp Biol Med. 2015;159:704-7 pubmed publisher
    Removal of Mg2+ ions from perfusion medium provoked epileptiform activity in CA1 field of surviving rat hippocampal slices manifested in generation of extra population spikes...
  69. Bamohabat S, NouriNezhad J, Mazaheri Y. Quantitative prenatal growth of the cervical sympathetic trunk components in sheep (Ovis arise) during the foetal period. Folia Morphol (Warsz). 2018;77:456-463 pubmed publisher
    ..of constant cranial cervical ganglion (CCG), three inconstant main, first, second middle cervical ganglia (MG, MG1, MG2), and interganglionic branch (IGB) were taken to determine normal foetal growth rates and patterns of cervical ..
  70. Sahadeo E, Song J, Gaskell K, Kim N, Rubloff G, Lee S. Investigation of the water-stimulated Mg2+ insertion mechanism in an electrodeposited MnO2 cathode using X-ray photoelectron spectroscopy. Phys Chem Chem Phys. 2018;20:2517-2526 pubmed publisher
    ..A more full understanding of the role of the water molecules is important to aid in the future design of cathode materials, especially when determining potential ways to integrate metal oxides in Mg batteries. ..
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    ..Cations that are incapable of cross-linking alginate, such as Na+ and Mg2+, do not induce gel folding. Moreover, the striking aspect is the direction of folding...
  72. Drisdell W, Poloni R, McDonald T, Pascal T, Wan L, Das Pemmaraju C, et al. Probing the mechanism of COâ‚‚ capture in diamine-appended metal-organic frameworks using measured and simulated X-ray spectroscopy. Phys Chem Chem Phys. 2015;17:21448-57 pubmed publisher
    ..Distinct spectral changes at the N and O K-edges are apparent upon CO2 adsorption in both mmen-Mg2(dobpdc) and mmen-Mn2(dobpdc), and these are evaluated based upon computed spectra from three potential adsorption ..
  73. Ejaz A, Ordonez H, Jacewicz A, Ferrao R, Shuman S. Structure of mycobacterial 3'-to-5' RNA:DNA helicase Lhr bound to a ssDNA tracking strand highlights distinctive features of a novel family of bacterial helicases. Nucleic Acids Res. 2017;: pubmed publisher
    ..The crystal structure of Lhr-(1-856) in complex with AMPPNP•Mg2+ and ssDNA defines a new helicase family...
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    ..Our data illustrate that [Mg2+]i plays a key role in control of HBV infection. ..
  75. Samuel D, Steinhauser C, Smith J, Kaufman A, Radin M, Naruse J, et al. Ion Pairing and Diffusion in Magnesium Electrolytes Based on Magnesium Borohydride. ACS Appl Mater Interfaces. 2017;: pubmed publisher
    ..The salt agglomeration rate and diffusivity of Mg2+ were both observed to correlate with solvent self-diffusivity: electrolytes using longer-(shorter-)chain solvents ..
  76. Patel K, Terán D, Zheng S, Kandale A, Garcia M, Lv Y, et al. Crystal structures of Staphylococcus aureus ketol-acid reductoisomerase in complex with two transition state analogs that have biocidal activity. Chemistry. 2017;: pubmed publisher
    Ketol-acid reductoisomerase (KARI) is an NAD(P)H and Mg2+-dependent enzyme of the branched-chain amino acid (BCAA) biosynthesis pathway...
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    ..4 to 6.0. The enhancement of Syn-1A binding to SUR2A by acidic pH was further regulated by Mg2+ and ATP. Therefore, pH regulates Kir.6.2/SUR2A channels not only by its direct actions on the Kir6...
  78. Le S, Serrano E, Kawamura R, Carrasco B, Yan J, Alonso J. Bacillus subtilis RecA with DprA-SsbA antagonizes RecX function during natural transformation. Nucleic Acids Res. 2017;45:8873-8885 pubmed publisher
    ..We showed that RecA, in the rATP·Mg2+ bound form (RecA·ATP), could not compete with RecX, SsbA or SsbB for assembly onto single-stranded (ss)DNA, but ..
  79. Prabakar S, Park C, Ikhe A, Sohn K, Pyo M. Simultaneous Suppression of Metal Corrosion and Electrolyte Decomposition by Graphene Oxide Protective Coating in Magnesium-Ion Batteries: Toward a 4V-wide Potential Window. ACS Appl Mater Interfaces. 2017;: pubmed publisher
    ..0 V vs. Mg/Mg2+) with no impact on reversible Mg plating/stripping reactions...
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    ..Kinetic studies showed that the activity was optimal at pH 8.0 and was activated by Mg2+. No neutral or acid pyrophosphatase was detected...
  81. Guo J, Zhang Y, Cheng L, Iwasaki H, Wang H, Kubota T, et al. Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12. FEBS Lett. 2002;524:211-8 pubmed
    ..Since mucins are glycoproteins mainly produced in the digestive organs, our results suggest that pp-GalNAc-T12 plays an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs. ..
  82. Grys T, Siegel M, Lathem W, Welch R. The StcE protease contributes to intimate adherence of enterohemorrhagic Escherichia coli O157:H7 to host cells. Infect Immun. 2005;73:1295-303 pubmed publisher
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  83. Ramaen O, Leulliot N, Sizun C, Ulryck N, Pamlard O, Lallemand J, et al. Structure of the human multidrug resistance protein 1 nucleotide binding domain 1 bound to Mg2+/ATP reveals a non-productive catalytic site. J Mol Biol. 2006;359:940-9 pubmed
    ..ATPase activity of isolated MRP1-NBDs allowed us to obtain the structure of wild-type NBD1 in complex with Mg2+/ATP...
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    ..This gallic acid-based colorimetric sensor shown a great potential for the selective detection of pathologically important electrolyte Mg2+ without any interference from other cations Ca2+ and K+. ..
  85. Sun J, Gao X, Meng D, Xu Y, Wang X, Gu X, et al. Antagomirs Targeting MicroRNA-134 Increase Limk1 Levels After Experimental Seizures in Vitro and in Vivo. Cell Physiol Biochem. 2017;43:636-643 pubmed publisher
    ..Low Mg2+-exposed primary neurons were used as an in vitro model of SE...
  86. Xu D, Pavlidis P, Taskent R, Alachiotis N, Flanagan C, DeGiorgio M, et al. Archaic Hominin Introgression in Africa Contributes to Functional Salivary MUC7 Genetic Variation. Mol Biol Evol. 2017;34:2704-2715 pubmed publisher
    One of the most abundant proteins in human saliva, mucin-7, is encoded by the MUC7 gene, which harbors copy number variable subexonic repeats (PTS-repeats) that affect the size and glycosylation potential of this protein...
  87. Oumer O, Abate D. Characterization of Pectinase from Bacillus subtilis Strain Btk 27 and Its Potential Application in Removal of Mucilage from Coffee Beans. Enzyme Res. 2017;2017:7686904 pubmed publisher
    ..5 and 50°C. Also, the enzyme activity was found stimulated with Mg2+ and Ca2+ metal ions. Moreover, it was stable on EDTA, Trixton-100, Tween 80, and Tween 20...
  88. Neuner S, Falschlunger C, Fuchs E, Himmelstoss M, Ren A, Patel D, et al. Atom-Specific Mutagenesis Reveals Structural and Catalytic Roles for an Active-Site Adenosine and Hydrated Mg2+ in Pistol Ribozymes. Angew Chem Int Ed Engl. 2017;: pubmed publisher
    ..A mechanistic proposal is suggested, with A32 playing a structural role and hydrated Mg2+ playing a catalytic role in cleavage...
  89. Zdrachek E, Bakker E. Time-Dependent Determination of Unbiased Selectivity Coefficients of Ion-Selective Electrodes for Multivalent Ions. Anal Chem. 2017;: pubmed publisher
    ..The applicability of the method is demonstrated for ionophore-based Mg2+-, Ca2+- and Na+-selective electrodes...
  90. Ueda K, Inagaki N, Seino S. MgADP antagonism to Mg2+-independent ATP binding of the sulfonylurea receptor SUR1. J Biol Chem. 1997;272:22983-6 pubmed
    ..was efficiently photolabeled with 8-azido-[alpha-32P]ATP and 8-azido-[gamma-32P]ATP in the presence or absence of Mg2+ or vanadate. NBF1 mutations impaired ATP binding, but NBF2 mutations did not...
  91. Wang H, Tachibana K, Zhang Y, Iwasaki H, Kameyama A, Cheng L, et al. Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14. Biochem Biophys Res Commun. 2003;300:738-44 pubmed
    ..recombinant pp-GalNAc-T14 transferred GalNAc to a panel of mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58)...
  92. Samuels T, Handler E, Syring M, Pajewski N, Blumin J, Kerschner J, et al. Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux. Ann Otol Rhinol Laryngol. 2008;117:688-95 pubmed
    ..These mucin genes were up-regulated after exposure to low pH in vitro (p < 0.005). Pepsin inhibited this up-regulation (p <0.001). Reflux laryngitis is associated with down-regulation of mucin gene expression. ..