MUC5B

Summary

Gene Symbol: MUC5B
Description: mucin 5B, oligomeric mucus/gel-forming
Alias: MG1, MUC-5B, MUC5, MUC9, mucin-5B, cervical mucin MUC5B, high molecular weight salivary mucin MG1, mucin 5, subtype B, tracheobronchial, sublingual gland mucin
Species: human
Products:     MUC5B

Top Publications

  1. Thornton D, Gray T, Nettesheim P, Howard M, Koo J, Sheehan J. Characterization of mucins from cultured normal human tracheobronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2000;278:L1118-28 pubmed
    ..epithelium over a 2- to 3-wk period and express increasing mRNA levels of the airway mucin genes MUC5AC and MUC5B as the cultures age; the levels of MUC2 mRNA were very low throughout the study...
  2. Desseyn J, Buisine M, Porchet N, Aubert J, Laine A. Genomic organization of the human mucin gene MUC5B. cDNA and genomic sequences upstream of the large central exon. J Biol Chem. 1998;273:30157-64 pubmed
    The complete structure of the DNA encoding the polypeptide chain of human mucin MUC5B has been determined...
  3. Henke M, Renner A, Huber R, Seeds M, Rubin B. MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions. Am J Respir Cell Mol Biol. 2004;31:86-91 pubmed
    ..part to mucus hypersecretion, there are no published data showing an increase in the gel-forming mucins MUC5AC or MUC5B in CF secretions...
  4. Casalino Matsuda S, Monzon M, Day A, Forteza R. Hyaluronan fragments/CD44 mediate oxidative stress-induced MUC5B up-regulation in airway epithelium. Am J Respir Cell Mol Biol. 2009;40:277-85 pubmed publisher
    Mucus hypersecretion with elevated MUC5B mucin production is a pathologic feature in many airway diseases associated with oxidative stress...
  5. Macneal K, Schwartz D. The genetic and environmental causes of pulmonary fibrosis. Proc Am Thorac Soc. 2012;9:120-5 pubmed publisher
    ..and environmental causes of pulmonary fibrosis, specifically focusing on genetic and epigenetic variants of MUC5B and several types of ILD, to discuss why only some individuals with the MUC5B promoter polymorphism develop ..
  6. Pramanik R, Osailan S, Challacombe S, Urquhart D, Proctor G. Protein and mucin retention on oral mucosal surfaces in dry mouth patients. Eur J Oral Sci. 2010;118:245-53 pubmed publisher
    ..High-molecular-weight mucin (MUC5B) was present in greater amounts on the anterior tongue than on other surfaces in control subjects...
  7. Stock C, Sato H, Fonseca C, Banya W, Molyneaux P, Adamali H, et al. Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in systemic sclerosis or sarcoidosis. Thorax. 2013;68:436-41 pubmed publisher
    A polymorphism (rs35705950) 3 kb upstream of MUC5B, the gene encoding Mucin 5 subtype B, has been shown to be associated with familial and sporadic idiopathic pulmonary fibrosis (IPF)...
  8. Thornton D, Rousseau K, McGuckin M. Structure and function of the polymeric mucins in airways mucus. Annu Rev Physiol. 2008;70:459-86 pubmed
    ..In normal physiology, the secreted mucins, in particular the polymeric mucins MUC5AC and MUC5B, provide the organizing framework of the airways mucus gel and are major contributors to its rheological ..
  9. Kirkham S, Kolsum U, Rousseau K, Singh D, Vestbo J, Thornton D. MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008;178:1033-9 pubmed publisher
    ..MUC5AC and MUC5B were the major mucins...

More Information

Publications102 found, 100 shown here

  1. Seibold M, Smith R, Urbanek C, Groshong S, Cosgrove G, Brown K, et al. The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium. PLoS ONE. 2013;8:e58658 pubmed publisher
    We previously identified a MUC5B gene promoter-variant that is a risk allele for sporadic and familial Idiopathic Pulmonary Fibrosis/Usual Interstitial Pneumonia (IPF/UIP)...
  2. Kamio K, Matsushita I, Hijikata M, Kobashi Y, Tanaka G, Nakata K, et al. Promoter analysis and aberrant expression of the MUC5B gene in diffuse panbronchiolitis. Am J Respir Crit Care Med. 2005;171:949-57 pubmed
    ..We analyzed nucleotide sequences of regulatory region of six mucin genes--MUC1, MUC2, MUC4, MUC5AC, MUC5B, and MUC7--and detected their promoter polymorphisms...
  3. Kesimer M, Makhov A, Griffith J, Verdugo P, Sheehan J. Unpacking a gel-forming mucin: a view of MUC5B organization after granular release. Am J Physiol Lung Cell Mol Physiol. 2010;298:L15-22 pubmed publisher
    ..Our major interest is in lung mucins, but most particularly in MUC5B, which is the major gel-forming mucin in mucus, and which provides its major protective matrix...
  4. Habte H, de Beer C, Lotz Z, Roux P, Mall A. Anti-HIV-1 activity of salivary MUC5B and MUC7 mucins from HIV patients with different CD4 counts. Virol J. 2010;7:269 pubmed publisher
    We have previously shown that MUC5B and MUC7 mucins from saliva of HIV negative individuals inhibit HIV-1 activity by 100% in an in vitro assay...
  5. Sepper R, Prikk K, Metsis M, Sergejeva S, Pugatsjova N, Bragina O, et al. Mucin5B expression by lung alveolar macrophages is increased in long-term smokers. J Leukoc Biol. 2012;92:319-24 pubmed publisher
    This study investigated the expression of MUC5B by AMs in the lungs of cigarette smokers and nonsmokers...
  6. Hunninghake G, Hatabu H, Okajima Y, Gao W, Dupuis J, Latourelle J, et al. MUC5B promoter polymorphism and interstitial lung abnormalities. N Engl J Med. 2013;368:2192-200 pubmed publisher
    A common promoter polymorphism (rs35705950) in MUC5B, the gene encoding mucin 5B, is associated with idiopathic pulmonary fibrosis...
  7. Zalewska A, Zwierz K, Zółkowski K, Gindzienski A. Structure and biosynthesis of human salivary mucins. Acta Biochim Pol. 2000;47:1067-79 pubmed
    Human salivary glands secrete two types of mucins: oligomeric mucin (MG1) with molecular mass above 1 MDa and monomeric mucin (MG2) with molecular mass of 200-250 kDa...
  8. Woo H, Yoo W, Bae C, Song S, Kim Y, Park S, et al. Leptin up-regulates MUC5B expression in human airway epithelial cells via mitogen-activated protein kinase pathway. Exp Lung Res. 2010;36:262-9 pubmed publisher
    ..Treatment with leptin significantly increased the expression of MUC5AC and MUC5B in NCI-H292 cells; these effects were blocked by mutant leptin...
  9. Peljto A, Steele M, Fingerlin T, Hinchcliff M, Murphy E, Podlusky S, et al. The pulmonary fibrosis-associated MUC5B promoter polymorphism does not influence the development of interstitial pneumonia in systemic sclerosis. Chest. 2012;142:1584-1588 pubmed publisher
    ..We recently identified a common variant in the promoter region of MUC5B (rs35705950) that has a significant effect on the risk of developing both familial and sporadic forms of IP...
  10. Peljto A, Zhang Y, Fingerlin T, Ma S, Garcia J, Richards T, et al. Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis. JAMA. 2013;309:2232-9 pubmed publisher
    ..To determine whether the MUC5B promoter polymorphism (rs35705950), previously reported to be associated with the development of pulmonary ..
  11. Noth I, Zhang Y, Ma S, Flores C, Barber M, Huang Y, et al. Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. Lancet Respir Med. 2013;1:309-317 pubmed publisher
    ..Several rare genetic variants and one common single nucleotide polymorphism (SNP) of MUC5B have been associated with the disease...
  12. Thomsson K, Prakobphol A, Leffler H, Reddy M, Levine M, Fisher S, et al. The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and diverse. Glycobiology. 2002;12:1-14 pubmed
    ..The presence of MUC5B as the major mucin in this preparation was confirmed by amino acid analysis and its reactivity with the monoclonal ..
  13. Habte H, Mall A, de Beer C, Lotz Z, Kahn D. The role of crude human saliva and purified salivary MUC5B and MUC7 mucins in the inhibition of Human Immunodeficiency Virus type 1 in an inhibition assay. Virol J. 2006;3:99 pubmed
    ..The purpose of this study was to purify salivary MUC5B and MUC7 mucins from crude saliva and determine their anti-HIV-1 activities...
  14. Ali M, Pearson J. Upper airway mucin gene expression: a review. Laryngoscope. 2007;117:932-8 pubmed
    ..MUC5AC, MUC5B, and MUC2 are the principal gel-forming mucins secreted in the airway...
  15. Seibold M, WISE A, Speer M, Steele M, Brown K, Loyd J, et al. A common MUC5B promoter polymorphism and pulmonary fibrosis. N Engl J Med. 2011;364:1503-12 pubmed publisher
    ..b>MUC5B expression was assessed in lung tissue...
  16. Borie R, Crestani B, Dieude P, Nunes H, Allanore Y, Kannengiesser C, et al. The MUC5B variant is associated with idiopathic pulmonary fibrosis but not with systemic sclerosis interstitial lung disease in the European Caucasian population. PLoS ONE. 2013;8:e70621 pubmed publisher
    A polymorphism on the MUC5B promoter (rs35705950) has been associated with idiopathic pulmonary fibrosis (IPF) but not with systemic sclerosis (SSc) with interstitial lung disease (ILD)...
  17. Kubo F, Ariestanti D, Oki S, Fukuzawa T, Demizu R, Sato T, et al. Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells. Respir Res. 2019;20:11 pubmed publisher
    ..and neutrophilia) in parallel with elevated expression of genes involved in mucous cell metaplasia (Muc5ac, Muc5b, Slc26a4, and Clca1), fibrosis (Tgfb1, Col1a1, Fn1, and Tnc), and type 2 immune response (Il4, Il5, Il13, IL-25, ..
  18. Mall A, Habte H, Mthembu Y, Peacocke J, de Beer C. Mucus and Mucins: do they have a role in the inhibition of the human immunodeficiency virus?. Virol J. 2017;14:192 pubmed publisher
    ..Crude saliva and its purified mucins, MUC5B and MUC7, and the purified mucins from breast milk, MUC1 and MUC4 and pregnancy plug cervical mucus (MUC2, MUC5AC, ..
  19. Marcos López M, Calduch Giner J, Mirimin L, Maccarthy E, Rodger H, O Connor I, et al. Gene expression analysis of Atlantic salmon gills reveals mucin 5 and interleukin 4/13 as key molecules during amoebic gill disease. Sci Rep. 2018;8:13689 pubmed publisher
    ..Two mucins (muc5, muc18) showed differential regulation upon disease...
  20. Liu G, Cooley M, Nair P, Donovan C, Hsu A, Jarnicki A, et al. Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c. J Pathol. 2017;243:510-523 pubmed publisher
    ..Fbln1c-deficient (Fbln1c-/- ) mice had reduced mucin (MUC) 5 AC levels, but not MUC5B levels, in the airways as compared with wild-type (WT) mice...
  21. Kaur M, Hartling I, Burnett T, Polsky L, Donnan C, Leclerc H, et al. Rumen-protected B vitamin complex supplementation during the transition period and early lactation alters endometrium mRNA expression on day 14 of gestation in lactating dairy cows. J Dairy Sci. 2019;102:1642-1657 pubmed publisher
    ..related to embryo development, immune system, adhesion, and regulation of vitamin B molecules showed that OXTR, MUC5B, MUC1, IL1B, SPP, TRD, FZD8, and FOLR1 genes were significantly upregulated in the VB group...
  22. Bargagli E, Di Masi M, Perruzza M, Vietri L, Bergantini L, Torricelli E, et al. The pathogenetic mechanisms of cough in idiopathic pulmonary fibrosis. Intern Emerg Med. 2019;14:39-43 pubmed publisher
    ..Moreover, patients with the MUC5B polymorphism show more severe coughing as MUC5B encodes for the dominant mucin in the honeycomb cysts of IPF ..
  23. Gahring L, Myers E, Dunn D, Weiss R, Rogers S. Nicotinic alpha 7 receptor expression and modulation of the lung epithelial response to lipopolysaccharide. PLoS ONE. 2017;12:e0175367 pubmed publisher
    ..n. LPS. Transcripts specific to Club cells (e.g., CC10, secretoglobins and Muc5b) or to ATII cells (e.g...
  24. Livraghi Butrico A, Grubb B, Kelly E, Wilkinson K, Yang H, Geiser M, et al. Genetically determined heterogeneity of lung disease in a mouse model of airway mucus obstruction. Physiol Genomics. 2012;44:470-84 pubmed publisher
    ..which correlated with the incidence of upper airway mucus plugging and the levels of Muc5b in bronchoalveolar lavage...
  25. Dietert K, Mundhenk L, Erickson N, Reppe K, Hocke A, Kummer W, et al. Murine CLCA5 is uniquely expressed in distinct niches of airway epithelial cells. Histochem Cell Biol. 2015;143:277-87 pubmed publisher
    ..Moreover, we determined mRNA levels of functionally related genes (mClca3, mClca5, Muc5ac and Muc5b) and quantified mCLCA5-, mCLCA3- and CC10-positive cells and periodic acid-Schiff-positive mucus cells in naive, ..
  26. Lindner K, Webering S, Stroebele M, Bockhorn H, Hansen T, König P, et al. Low Dose Carbon Black Nanoparticle Exposure Does Not Aggravate Allergic Airway Inflammation in Mice Irrespective of the Presence of Surface Polycyclic Aromatic Hydrocarbons. Nanomaterials (Basel). 2018;8: pubmed publisher
    ..1b1), oxidative stress (HO-1, Gr, Gpx-3), inflammation (KC, Mcp-1, IL-6, IL-13, IL-17a), mucin synthesis (Muc5ac, Muc5b), the histology of mucus-producing goblet cells, ciliary beat frequency (CBF), and the particle transport speed...
  27. Patnode M, Cheng C, Chou C, Singer M, Elin M, Uchimura K, et al. Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue. J Biol Chem. 2013;288:26533-45 pubmed publisher
    ..Siglec-F ligand activity in bronchoalveolar lavage fluid fractions containing polymeric secreted mucins, including MUC5B. Consistent with these observations, ligands in the lung increase dramatically during infection with the parasitic ..
  28. Van Der Velden J, Ye Y, Nolin J, Hoffman S, Chapman D, Lahue K, et al. JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers. Clin Transl Med. 2016;5:36 pubmed publisher
    ..model, CC-930 attenuated collagen 1A1 gene expression, peribronchiolar collagen deposition, airway mucin MUC5B expression in club cells, and MMP-7 expression in lung, bronchoalveolar lavage fluid, and serum...
  29. Du J, Ba L, Li B, Liu F, Hu X, Zhang J, et al. Distinct expression of NK2 homeobox 1 (NKX2-1) and goblet cell hyperplasia in nasal polyps with different endotypes. Int Forum Allergy Rhinol. 2017;7:690-698 pubmed publisher
    ..05). The expression of mucin 5AC (MUC5AC) and MUC5B, as well as goblet cells hyperplasia, were significantly elevated in IL-5+ NPs, which correlated with ..
  30. Nakano Y, Yang I, Walts A, Watson A, Helling B, Fletcher A, et al. MUC5B Promoter Variant rs35705950 Affects MUC5B Expression in the Distal Airways in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2016;193:464-6 pubmed publisher
  31. Alenmyr L, Herrmann A, Hogestatt E, Greiff L, Zygmunt P. TRPV1 and TRPA1 stimulation induces MUC5B secretion in the human nasal airway in vivo. Clin Physiol Funct Imaging. 2011;31:435-44 pubmed publisher
    ..various TRP ion channel agonists on symptoms and secretion of specific mucins: mucin 5 subtype AC (MUC5AC) and B (MUC5B)...
  32. Kiwamoto T, Katoh T, Evans C, Janssen W, Brummet M, Hudson S, et al. Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis. J Allergy Clin Immunol. 2015;135:1329-1340.e9 pubmed publisher
    ..Proteomic analysis of Siglec-F binding material identified Muc5b and Muc4...
  33. Montalvo Javé E, Mendoza Barrera G, Valderrama Treviño A, Piña Barba M, Montalvo Arenas C, Rojas Mendoza F, et al. Absorbable bioprosthesis for the treatment of bile duct injury in an experimental model. Int J Surg. 2015;20:163-9 pubmed publisher
    ..Histological and immunohistochemical staining (CK19 and MUC5+) revealed the presence of biliary epithelium with intramural biliary glands in all the experimental models...
  34. Meyerholz D, Lambertz A, Reznikov L, Ofori Amanfo G, Karp P, McCray P, et al. Immunohistochemical Detection of Markers for Translational Studies of Lung Disease in Pigs and Humans. Toxicol Pathol. 2016;44:434-41 pubmed publisher
    ..may be involved with tissue remodeling (alpha-smooth muscle actin, beta-tubulin-III, lactoferrin, mucin [MUC]5AC, MUC5B, and cystic fibrosis transmembrane conductance regulator [CFTR]) for study of lung tissues...
  35. Portal C, Gouyer V, Magnien M, Plet S, Gottrand F, Desseyn J. In vivo imaging of the Muc5b gel-forming mucin. Sci Rep. 2017;7:44591 pubmed publisher
    ..A Muc5b-GFP tagged reporter mouse was used to assess Muc5b production in mouse tissues by immunofluorescence microscopy ..
  36. Drakopanagiotakis F, Wujak L, Wygrecka M, Markart P. Biomarkers in idiopathic pulmonary fibrosis. Matrix Biol. 2018;68-69:404-421 pubmed publisher
    ..Furthermore, genetic variants of TOLLIP, MUC5B, and other genes are associated with a differential response to treatment and with the development and/or the ..
  37. Guzman K, Bader T, Nettesheim P. Regulation of MUC5 and MUC1 gene expression: correlation with airway mucous differentiation. Am J Physiol. 1996;270:L846-53 pubmed
    ..We report the isolation and characterization of the rat cDNA homologue of the human airway secretory mucin, MUC5. Furthermore, we demonstrate the coordinate regulation of the expression of MUC5 and MUC1 (a membrane-bound mucin) ..
  38. Piras M, Hand A, Tore G, Ledda G, Piludu M. Ultrastructural localization of salivary mucins MUC5B and MUC7 in human labial glands. Eur J Oral Sci. 2010;118:14-8 pubmed publisher
    ..In this study, we investigated the ultrastructural localization of the MUC5B and MUC7 mucins in human labial glands by means of a postembedding immunogold technique...
  39. Zhang Z, Zhu Z, Bai C, Chen Z. Aquaporin 5 expression increases mucin production in lung adenocarcinoma. Oncol Rep. 2011;25:1645-50 pubmed publisher
    ..We tested MUC5AC and MUC5B mucin production induced by AQP5 expression in lung adenocarcinoma metastasis...
  40. Horsley A, Rousseau K, Ridley C, Flight W, Jones A, Waigh T, et al. Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis. J Cyst Fibros. 2014;13:260-6 pubmed publisher
    There is conflicting evidence about the importance of airway mucins (MUC5AC and MUC5B) in determining physical properties of sputum in cystic fibrosis (CF)...
  41. Ikeda Kurosawa C, Higashio H, Nakano M, Okubo M, Satoh Y, Kurosaka D, et al. α1-Adrenoceptors relate Ca(2+) modulation and protein secretions in rat lacrimal gland. Biomed Res. 2015;36:357-69 pubmed publisher
    ..The RT-PCR results showed that MUC1, MUC4, MUC5AC, MUC5B, and MUC16 were expressed in acinar cells...
  42. Val S, Poley M, Brown K, Choi R, Jeong S, Colberg Poley A, et al. Proteomic Characterization of Middle Ear Fluid Confirms Neutrophil Extracellular Traps as a Predominant Innate Immune Response in Chronic Otitis Media. PLoS ONE. 2016;11:e0152865 pubmed publisher
    ..and immunoblotting demonstrated the presence of neutrophil extracellular traps (NETs) in every MEE, along with MUC5B colocalization. DNA found in effusions revealed unfragmented DNA of human origin...
  43. Yoo K, Choi H, Jun D, Lee H, Lee O, Yoon B, et al. MUC Expression in Gallbladder Epithelial Tissues in Cholesterol-Associated Gallbladder Disease. Gut Liver. 2016;10:851-8 pubmed publisher
    ..Canine GBECs treated with lipopolysaccharide were also studied. MUC3, MUC5AC, MUC5B, and MUC6 antibodies were used for dot/slot immunoblotting and immunohistochemical studies of the gallbladder ..
  44. White S, Kim D, Guo Y, Li W, Yang Y, Chen J, et al. Biofunctionalized Hybrid Magnetic Gold Nanoparticles as Catalysts for Photothermal Ablation of Colorectal Liver Metastases. Radiology. 2017;285:809-819 pubmed publisher
    Purpose To demonstrate that anti-MG1 conjugated hybrid magnetic gold nanoparticles (HNPs) act as a catalyst during photothermal ablation (PTA) of colorectal liver metastases, and thus increase ablation zones...
  45. Guan Y, Zhu J, Shen J, Jia Y, Jin Y, Dong X, et al. Salvianolic acid B improves airway hyperresponsiveness by inhibiting MUC5AC overproduction associated with Erk1/2/P38 signaling. Eur J Pharmacol. 2018;824:30-39 pubmed publisher
    ..that SalB attenuated OVA-induced eosinophil infiltration, airway goblet cell hyperplasia, and MUC5AC and MUC5B mRNA and protein expression in lung tissues...
  46. Bae C, Choi Y, Song S, Kim Y. Effect of thymic stromal lymphopoietin on MUC5B expression in human airway epithelial cells. Biochem Biophys Res Commun. 2014;448:231-5 pubmed publisher
    ..In human NCI-H292 airway epithelial cells, TSLP increased MUC5B expression. TSLP significantly activated phosphorylation of ERK1/2 and p38 mitogen-activated protein kinase (MAPK)...
  47. Fang H, Li Q, He W, Li J, Xue Q, Xu C, et al. A high performance triboelectric nanogenerator for self-powered non-volatile ferroelectric transistor memory. Nanoscale. 2015;7:17306-11 pubmed publisher
    ..Meanwhile, the arch-shaped TENG is shown to be able to pole a bulk ferroelectric 0.65Pb(Mg1/3Nb2/3)O3-0.35PbTiO3 (PMN-PT) single crystal directly...
  48. Arts J, Irfan M, Keene A, Kreiling R, Lyon D, Maier M, et al. Case studies putting the decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping) into practice. Regul Toxicol Pharmacol. 2016;76:234-61 pubmed publisher
    ..These are soluble nanomaterials (MG1) whose further hazard assessment should rely on read-across to the dissolved materials, high aspect-ratio ..
  49. Wang F, Zhou C, Gesang D, Jiang C. Electric field control of magnetization reorientation in Co/Pb (Mg1/3Nb2/3)-PbTiO3 heterostructure. Nanoscale Res Lett. 2017;12:104 pubmed publisher
    ..These results demonstrated that converse magnetoelectric effect in the FM/FE heterostructure was indeed a feasible method to control magnetization orientation in technologically relevant ferromagnetic thin films at room temperature. ..
  50. Portal C, Gouyer V, Gottrand F, Desseyn J. Preclinical mouse model to monitor live Muc5b-producing conjunctival goblet cell density under pharmacological treatments. PLoS ONE. 2017;12:e0174764 pubmed publisher
    ..We created a reporter mouse for the gel-forming mucin gene Muc5b. Muc5b-positive goblet cells were studied in the eye conjunctiva by immunohistochemistry and probe-based confocal ..
  51. Lee J, Kim Y, Im C, Kim S, Kim S, Min S, et al. Grape Seed Proanthocyanidin Inhibits Mucin Synthesis and Viral Replication by Suppression of AP-1 and NF-?B via p38 MAPKs/JNK Signaling Pathways in Respiratory Syncytial Virus-Infected A549 Cells. J Agric Food Chem. 2017;65:4472-4483 pubmed publisher
    ..cells with or without exposure to RSV with 5-10 ?g GSP/mL, the expression of various mucins (MUC1, MUC2, MUC5AC, MUC5B, and MUC8) was evaluated by real-time polymerase chain reaction, enzyme-linked immunosorbent assay, and Western ..
  52. Raynal B, Hardingham T, Sheehan J, Thornton D. Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus. J Biol Chem. 2003;278:28703-10 pubmed
    ..This fraction of saliva was shown to contain MUC5B as the single major protein species by positive ion electrospray ionization-tandem mass spectrometry analysis...
  53. Conti C, Montero Fernandez A, Borg E, Osadolor T, Viola P, De Lauretis A, et al. Mucins MUC5B and MUC5AC in Distal Airways and Honeycomb Spaces: Comparison among Idiopathic Pulmonary Fibrosis/Usual Interstitial Pneumonia, Fibrotic Nonspecific Interstitial Pneumonitis, and Control Lungs. Am J Respir Crit Care Med. 2016;193:462-4 pubmed publisher
  54. Moran R, McKay D, Pickard C, Berry A, Griffin J, Ashbrook S. Hunting for hydrogen: random structure searching and prediction of NMR parameters of hydrous wadsleyite. Phys Chem Chem Phys. 2016;18:10173-81 pubmed publisher
    ..Aligning with previous experimental work, we solely consider models with Mg3 (over Mg1, Mg2 or Si) vacancies...
  55. Wagener K, Pothmann H, Prunner I, Peter S, Erber R, Aurich C, et al. Endometrial mRNA expression of selected pro-inflammatory factors and mucins in repeat breeder cows with and without subclinical endometritis. Theriogenology. 2017;90:237-244 pubmed publisher
    ..3, CXCL5, prostaglandin-endoperoxide synthase 2 (PTGS2), tracheal antimicrobial peptide (TAP) and mucin (MUC) 4, MUC5, MUC6, MUC12 and MUC16...
  56. Lin L, Lu Q, Tang X, Dai F, Wei J. [Nasal irrigation for the treatment of vasomotor rhinitis: a pilot study]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017;52:446-452 pubmed publisher
    ..0?SF?12v2)??????????????????(ELISA)?????????????????????3??????????SP?MUC 5B?????????????SP???????????????????MUC5B?????Graphpad Prism 6???????????? ??? 101?VMR???90?????????????1??????..
  57. Shen D, Yuan F, Hou J. [Effect of annexin A2 on EGFR/NF-?B signal transduction and mucin expression in human airway epithelial cells treated with Mycoplasma pneumoniae]. Zhongguo Dang Dai Er Ke Za Zhi. 2017;19:820-825 pubmed
    ..and phosphorylated p65 NF-?B (p-p65 NF-?B); ELISA was used to measure the secretion of mucin 5AC (MUC5AC) and mucin 5B (MUC5B). The MP and NC-siRNA+MP groups had lower cell viability than the control group (P<0.05)...
  58. Horimasu Y, Ohshimo S, Bonella F, Tanaka S, Ishikawa N, Hattori N, et al. MUC5B promoter polymorphism in Japanese patients with idiopathic pulmonary fibrosis. Respirology. 2015;20:439-44 pubmed publisher
    A single nucleotide polymorphism (SNP) rs35705950 in the promoter of Mucin 5B (MUC5B) has been reported to be associated with idiopathic pulmonary fibrosis (IPF) mainly in Caucasian populations...
  59. Wang S, Han H, Hu Y, Yang W, Lv Y, Wang L, et al. SLC3A2, antigen of mAb 3G9, promotes migration and invasion by upregulating of mucins in gastric cancer. Oncotarget. 2017;8:88586-88598 pubmed publisher
    ..Mechanistic investigations suggested that MUC1, MUC16 and MUC5B were the downstream genes of SLC3A2 in GC cells...
  60. Chen Y, Zhao Y, Di Y, Wu R. Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region. Am J Respir Cell Mol Biol. 2001;25:542-53 pubmed
    ..In situ hybridization demonstrated that MUC5B message was expressed mainly in the mucous cells of submucosal glands of normal human airway tissues...
  61. Zhu Q, Zhang X, Zhang S, Tang S, Min H, Yi L, et al. Association Between the MUC5B Promoter Polymorphism rs35705950 and Idiopathic Pulmonary Fibrosis: A Meta-analysis and Trial Sequential Analysis in Caucasian and Asian Populations. Medicine (Baltimore). 2015;94:e1901 pubmed publisher
    ..A number of studies reported the association between MUC5B promoter polymorphism rs35705950 and IPF, but substantial inconsistent findings were observed and the strength of ..
  62. Ridley C, Kirkham S, Williamson S, Davis C, Woodman P, Thornton D. Biosynthesis of the polymeric gel-forming mucin MUC5B. Am J Physiol Lung Cell Mol Physiol. 2016;310:L993-L1002 pubmed publisher
    b>MUC5B is a major polymeric mucin in the airway mucus gel and is an essential component of innate defense of the respiratory epithelium. Knowledge of the synthesis and intracellular processing of MUC5B is incomplete...
  63. Choi H, Chung Y, Kim H, Moon U, Choi Y, Van Seuningen I, et al. Signal pathway of 17beta-estradiol-induced MUC5B expression in human airway epithelial cells. Am J Respir Cell Mol Biol. 2009;40:168-78 pubmed publisher
    b>MUC5B is a major mucin of the human respiratory tract, and it is not clear how MUC5B expression is regulated in various airway diseases...
  64. Ju W, Yoo B, Kim I, Kim J, Kim S, Lee H. Identification of genes with differential expression in chemoresistant epithelial ovarian cancer using high-density oligonucleotide microarrays. Oncol Res. 2009;18:47-56 pubmed
    ..Downregulated genes in chemoresistant tumors included genes related to cell adhesion (MUC5B, CITED2), transcription regulating genes (FOXD1, MAD1L1, PAX2), genes involving signal transduction (SOSTDC1, SNX1,..
  65. Zhang Y, Noth I, Garcia J, Kaminski N. A variant in the promoter of MUC5B and idiopathic pulmonary fibrosis. N Engl J Med. 2011;364:1576-7 pubmed publisher
  66. Macarthur C, Wilmot B, Wang L, Schüller M, Lighthall J, Trune D. Genetic susceptibility to chronic otitis media with effusion: candidate gene single nucleotide polymorphisms. Laryngoscope. 2014;124:1229-35 pubmed publisher
    ..05 for association with the chronic otitis media with effusion phenotype (TLR4, MUC5B, SMAD2, SMAD4); five of these polymorphisms were in the TLR4 gene...
  67. Wang W, Shao S, Wang S. The role for human nasal epithelial nuclear factor kappa B activation in histamine-induced mucin 5 subtype B overproduction. Int Forum Allergy Rhinol. 2016;6:264-70 pubmed publisher
    Mucin 5 subtype B (MUC5B) is 1 of the major mucins secreted by airway epithelial cells. We sought to determine the effect of histamine on MUC5B expression in human nasal epithelial cells...
  68. Lahdaoui F, Messager M, Vincent A, Hec F, Gandon A, Warlaumont M, et al. Depletion of MUC5B mucin in gastrointestinal cancer cells alters their tumorigenic properties: implication of the Wnt/?-catenin pathway. Biochem J. 2017;474:3733-3746 pubmed publisher
    ..The secreted mucin MUC5B is overexpressed in certain subtypes of gastric and intestinal cancers, but the consequences of this altered ..
  69. Alliende C, Kwon Y, Brito M, Molina C, Aguilera S, Perez P, et al. Reduced sulfation of muc5b is linked to xerostomia in patients with Sjögren syndrome. Ann Rheum Dis. 2008;67:1480-7 pubmed
    b>MUC5B contains sulfated and sialylated oligosaccharides that sequester water required for moisturising the oral mucosa...
  70. Donoghue L, Livraghi Butrico A, McFadden K, Thomas J, Chen G, Grubb B, et al. Identification of trans Protein QTL for Secreted Airway Mucins in Mice and a Causal Role for Bpifb1. Genetics. 2017;207:801-812 pubmed publisher
    ..The mucin proteins MUC5AC and MUC5B are the major glycoprotein components of mucus and have critical roles in airway defense...
  71. Ma J, Rubin B, Voynow J. Mucins, Mucus, and Goblet Cells. Chest. 2018;154:169-176 pubmed publisher
    ..those that are secreted but do not polymerize (MUC7), those that are secreted and polymerize to form gels (MUC5AC, MUC5B), and those that have transmembrane domains and are cell surface associated (MUC1, MUC4, MUC16, MUC20)...
  72. Kettle R, Simmons J, Schindler F, Jones P, Dicker T, Dubois G, et al. Regulation of neuregulin 1beta1-induced MUC5AC and MUC5B expression in human airway epithelium. Am J Respir Cell Mol Biol. 2010;42:472-81 pubmed publisher
    ..The mucins, MUC5AC and MUC5B, contribute to the viscoelastic properties of mucus, and are found at elevated levels in the airways of ..
  73. Jinnai M, Niimi A, Ueda T, Matsuoka H, Takemura M, Yamaguchi M, et al. Induced sputum concentrations of mucin in patients with asthma and chronic cough. Chest. 2010;137:1122-9 pubmed publisher
    ..were measured by enzyme-linked immunosorbent assay, which detects airway mucin, probably including MUC5AC and MUC5B. Mucin levels were higher in patients with CA (674.2 +/- 548.8 microg/mL) and SBS (638.4 +/- 650...
  74. Silva M, Bercik P. Macrophages are related to goblet cell hyperplasia and induce MUC5B but not MUC5AC in human bronchus epithelial cells. Lab Invest. 2012;92:937-48 pubmed publisher
    ..to challenge primary culture of normal human bronchus epithelial cells (HBEC) in air-liquid interface, followed by MUC5B and MUC5AC mucin immunostaining...
  75. Liptzin D, Watson A, Murphy E, Kroehl M, Dishop M, Galambos C, et al. MUC5B expression and location in surfactant protein C mutations in children. Pediatr Pulmonol. 2015;50:1270-6 pubmed publisher
    ..The sources of phenotype variability are incompletely understood. A common MUC5B promoter variant rs35705950 is associated with adult Idiopathic Pulmonary Fibrosis (IPF)...
  76. García E, Tiscornia I, Libisch G, Trajtenberg F, Bollati Fogolín M, Rodríguez E, et al. MUC5B silencing reduces chemo-resistance of MCF-7 breast tumor cells and impairs maturation of dendritic cells. Int J Oncol. 2016;48:2113-23 pubmed publisher
    ..The secreted mucin MUC5B, the major component of the respiratory tract mucus, is aberrantly expressed in breast cancer, where it could ..
  77. Samuels T, Yan J, Khampang P, Dettmar P, Mackinnon A, Hong W, et al. Association of Gel-Forming Mucins and Aquaporin Gene Expression With Hearing Loss, Effusion Viscosity, and Inflammation in Otitis Media With Effusion. JAMA Otolaryngol Head Neck Surg. 2017;143:810-817 pubmed publisher
    ..Expression of the mucin 2 (MUC2), mucin 5AC (MUC5AC), mucin 5B (MUC5B), and AQP5 genes were assayed in middle ear biopsy specimens by quantitative polymerase chain reaction...
  78. Evans C, Kim K, Tuvim M, Dickey B. Mucus hypersecretion in asthma: causes and effects. Curr Opin Pulm Med. 2009;15:4-11 pubmed publisher
    ..Of the five secreted gel-forming mucins in mammals, only MUC5AC and MUC5B are produced in significant quantities in intrapulmonary airways...
  79. Ahn E, Kim W, Kwon J, Choi P, Kim W, Sunwoo Y, et al. Variants of MUC5B minisatellites and the susceptibility of bladder cancer. DNA Cell Biol. 2009;28:169-76 pubmed publisher
    The human MUC5B gene, which is primarily expressed in the tracheobronchial tract, is clustered to chromosome 11p15.5 with three other secreted gel-forming mucins, MUC6, MUC2, and MUC5AC...
  80. Jiang H, Hu Y, Shang L, Li Y, Yang L, Chen Y. Association between MUC5B polymorphism and susceptibility and severity of idiopathic pulmonary fibrosis. Int J Clin Exp Pathol. 2015;8:14953-8 pubmed
    ..progressive pulmonary functional decline and death, in which the common variant in the promoter region of the mucin 5B (MUC5B) gene may be involved...
  81. Lee J, Lee J, Yun J, Jeong D, Kim J. DUSP28 links regulation of Mucin 5B and Mucin 16 to migration and survival of AsPC-1 human pancreatic cancer cells. Tumour Biol. 2016;37:12193-12202 pubmed
    ..Analysis using the Gene Expression Omnibus public microarray database indicated higher DUSP28, MUC1, MUC4, MUC5B, MUC16 and MUC20 messenger RNA (mRNA) levels in pancreatic cancers compared with normal pancreas tissues...
  82. Bonser L, Erle D. Airway Mucus and Asthma: The Role of MUC5AC and MUC5B. J Clin Med. 2017;6: pubmed publisher
    ..The polymeric mucins MUC5AC and MUC5B are integral components of airway mucus...
  83. Nielsen P, Bennett E, Wandall H, Therkildsen M, Hannibal J, Clausen H. Identification of a major human high molecular weight salivary mucin (MG1) as tracheobronchial mucin MUC5B. Glycobiology. 1997;7:413-9 pubmed
    ..A single clone, SAL1, was identified and found to be encoded by tracheobronchial mucin gene MUC5B. A previously reported partial cDNA sequence from salivary mucin was linked to SAL1/MUC5B by genomic cloning and ..
  84. Raynal B, Hardingham T, Thornton D, Sheehan J. Concentrated solutions of salivary MUC5B mucin do not replicate the gel-forming properties of saliva. Biochem J. 2002;362:289-96 pubmed
    ..b>MUC5B mucin, its reduced subunit and T-domains were prepared from saliva and fluorescently labelled...
  85. Walsh M, Clendenning M, Williamson E, Pearson S, Walters R, Nagler B, et al. Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype. Mod Pathol. 2013;26:1642-56 pubmed publisher
    ..We, therefore, investigated the protein expression levels of MUC2 and MUC5AC, as well as MUC5B and MUC6, in molecular subtypes of colorectal cancer...
  86. Nagashunmugam T, Malamud D, Davis C, Abrams W, Friedman H. Human submandibular saliva inhibits human immunodeficiency virus type 1 infection by displacing envelope glycoprotein gp120 from the virus. J Infect Dis. 1998;178:1635-41 pubmed
    ..It thus appears that specific salivary proteins interact with HIV-1 to strip gp120 from the virus with a resultant decrease in infectivity. ..
  87. Vilkin A, Geller A, Levi Z, Niv Y. Mucin gene expression in bile of patients with and without gallstone disease, collected by endoscopic retrograde cholangiography. World J Gastroenterol. 2009;15:2367-71 pubmed
    ..Dot blot analysis for bile mucin apoproteins was performed with antibodies to Mucin 1 (MUC1), MUC2, MUC3, MUC5AC, MUC5B and MUC6. Staining intensity score (0-3) was used as a measure of antigen expression...
  88. Monzon M, Forteza R, Casalino Matsuda S. MCP-1/CCR2B-dependent loop upregulates MUC5AC and MUC5B in human airway epithelium. Am J Physiol Lung Cell Mol Physiol. 2011;300:L204-15 pubmed publisher
    ..we found that MCP-1 has a novel function in airway epithelium, increasing the two major airway mucins MUC5AC and MUC5B, an effect mediated, at least in part, by a cascade of events initiated by interaction of its receptor CCR2B with ..
  89. Song S, Seo Y, Kim Y, Park S, Bae C, Kim Y. Effect of Onchocerca volvulus chitinase on MUC5B expression in human airway epithelial cells. Am J Rhinol Allergy. 2013;27:3-7 pubmed publisher
    ..In this study, the effect and brief signaling pathway of chitinase on MUC5B expression were investigated in human airway epithelial cells...
  90. Putman R, Rosas I, Hunninghake G. Genetics and early detection in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2014;189:770-8 pubmed publisher
    ..studies have demonstrated strong and replicable associations between a common promoter polymorphism in the mucin 5B gene (MUC5B) and both IPF and the presence of abnormal imaging findings in the general population...
  91. Chung J, Chawla A, Peljto A, Cool C, Groshong S, Talbert J, et al. CT scan findings of probable usual interstitial pneumonitis have a high predictive value for histologic usual interstitial pneumonitis. Chest. 2015;147:450-459 pubmed publisher
    ..the predictive effect of probable UIP on CT scan on histology and the effect of the promoter polymorphism in MUC5B (rs35705950) on histologic and CT scan UIP diagnosis...
  92. Saieg A, Brown K, Pena M, Rose M, Preciado D. Proteomic analysis of pediatric sinonasal secretions shows increased MUC5B mucin in CRS. Pediatr Res. 2015;77:356-62 pubmed publisher
    ..The global protein profile of sinonasal secretions in pediatric CRS has not been studied. We hypothesized that MUC5B, a glandular mucin, would be relatively increased in CRS secretions compared to other mucins...