MUC5AC

Summary

Gene Symbol: MUC5AC
Description: mucin 5AC, oligomeric mucus/gel-forming
Alias: MUC5, TBM, leB, mucin, mucin-5AC, gastric mucin, lewis B blood group antigen, major airway glycoprotein, mucin 5, subtypes A and C, tracheobronchial/gastric, mucin 5AC, oligomeric mucus/gel-forming pseudogene, mucin-5 subtype AC, tracheobronchial, tracheobronchial mucin
Species: human
Products:     MUC5AC

Top Publications

  1. Guyonnet Duperat V, Audie J, Debailleul V, Laine A, Buisine M, Galiegue Zouitina S, et al. Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?. Biochem J. 1995;305 ( Pt 1):211-9 pubmed
    ..The data suggest that MUC5A and MUC5C are part of the same gene (called MUC5AC) which is distinct from MUC5B...
  2. Nollet S, Forgue Lafitte M, Kirkham P, Bara J. Mapping of two new epitopes on the apomucin encoded by MUC5AC gene: expression in normal GI tract and colon tumors. Int J Cancer. 2002;99:336-43 pubmed
    ..We have mapped 2 new gastric mucin epitopes and the M1-f epitope previously characterized by the 19/21M1 MAbs on MUC5AC-encoded apomucin...
  3. Henke M, Renner A, Huber R, Seeds M, Rubin B. MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions. Am J Respir Cell Mol Biol. 2004;31:86-91 pubmed
    ..is due in part to mucus hypersecretion, there are no published data showing an increase in the gel-forming mucins MUC5AC or MUC5B in CF secretions...
  4. Shao M, Nadel J. Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme. J Immunol. 2005;175:4009-16 pubmed
    ..exists in high concentrations (1-20 microM) in airway secretions of these patients and induces overproduction of MUC5AC mucin, a major component of airway mucus...
  5. Kim S, Kwon C, Shin N, Park D, Moon H, Kim G, et al. Decreased Muc5AC expression is associated with poor prognosis in gastric cancer. Int J Cancer. 2014;134:114-24 pubmed publisher
    ..We investigated the effect of Muc5AC, a secreted mucin, on the invasiveness/migratory capability of gastric cancer cells and the prognostic ..
  6. Finzi L, Barbu V, Burgel P, Mergey M, Kirkwood K, Wick E, et al. MUC5AC, a gel-forming mucin accumulating in gallstone disease, is overproduced via an epidermal growth factor receptor pathway in the human gallbladder. Am J Pathol. 2006;169:2031-41 pubmed
    ..of TNF-alpha, EGF-R ligands (either EGF or transforming growth factor-alpha) caused significant increases in MUC5AC mRNA and protein production, whereas expression of the other gallbladder mucins MUC1, MUC3, and MUC5B was ..
  7. Hoshi H, Sawada T, Uchida M, Iijima H, Kimura K, Hirakawa K, et al. MUC5AC protects pancreatic cancer cells from TRAIL-induced death pathways. Int J Oncol. 2013;42:887-93 pubmed publisher
    We have previously reported that a specific siRNA transfected MUC5AC could knockdown MUC5AC expression and suppress in vivo tumor growth and metastasis, although it had no effects on in vitro cell growth, cell survival, proliferation and ..
  8. Forgue Lafitte M, Fabiani B, Levy P, Maurin N, Flejou J, Bara J. Abnormal expression of M1/MUC5AC mucin in distal colon of patients with diverticulitis, ulcerative colitis and cancer. Int J Cancer. 2007;121:1543-9 pubmed
    The abnormal expression of gastric M1/MUC5AC mucin in precancerous lesions and colon cancer evidenced by immunohistochemistry led us to check for its presence in the mucus obtained directly from patients undergoing surgery for cancerous (..
  9. Kim S, Hong J, Ryu S, Chung W, Yoon J, Koo J. Regulation of mucin gene expression by CREB via a nonclassical retinoic acid signaling pathway. Mol Cell Biol. 2007;27:6933-47 pubmed
    ..plays a critical role in regulating the expression of airway epithelial cell differentiation markers, the MUC2, MUC5AC, and MUC5B genes...

More Information

Publications82

  1. Park E, Gum J, Kakar S, Kwon S, Deng G, Kim Y. Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions. Int J Cancer. 2008;122:1253-60 pubmed
    ..production of intestinal goblet cell mucin, MUC2 and frequent ectopic expression of gastric foveolar mucin, MUC5AC. SOX2, an HMG-box transcription factor expressed in gastric mucosa but not in intestine is thought to play an ..
  2. Inaguma S, Kasai K, Ikeda H. GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin. Oncogene. 2011;30:714-23 pubmed publisher
    ..Increased expression of a gel-forming mucin, MUC5AC, was previously revealed as a major biomarker for the poor prognosis of PDA patients, but the molecular mechanisms ..
  3. Li D, Gallup M, Fan N, Szymkowski D, Basbaum C. Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts. J Biol Chem. 1998;273:6812-20 pubmed
    ..of rapid amplification of cDNA ends-polymerase chain reaction (RACE-PCR) in which the 5' sequence of the human gastric mucin cDNA HGM-1 (1) was used to design the first MUC5AC-specific primer...
  4. Kang J, Lee E, Park S, Chung I. MUC5AC expression through bidirectional communication of Notch and epidermal growth factor receptor pathways. J Immunol. 2011;187:222-9 pubmed publisher
    ..We investigated the involvement of Notch signaling in MUC5AC expression in NCI-H292 cells, a human lung carcinoma cell line...
  5. Ha U, Lim J, Jono H, Koga T, Srivastava A, Malley R, et al. A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae. J Immunol. 2007;178:1736-47 pubmed
    ..In this study, we show that pneumolysin is required for up-regulation of MUC5AC mucin via TLR4-dependent activation of ERK in human epithelial cells in vitro and in mice in vivo...
  6. Ding G, Zheng C. The expression of MUC5AC and MUC5B mucin genes in the mucosa of chronic rhinosinusitis and nasal polyposis. Am J Rhinol. 2007;21:359-66 pubmed
    The aim of this study was to investigate the expression of MUC5AC and MUC5B messenger RNAs (mRNAs) and localization of these proteins in human sinus mucosa of chronic rhinosinusitis (CRS) and CRS with nasal polyposis (CRS/NP)...
  7. Kim J, Chang J, Yoon J, Kwon S, Bae J, Kim K. [6]-Gingerol suppresses interleukin-1 beta-induced MUC5AC gene expression in human airway epithelial cells. Am J Rhinol Allergy. 2009;23:385-91 pubmed publisher
    ..The present study investigated whether [6]-gingerol suppresses interleukin (IL)-1 beta-induced MUC5AC gene expression in human airway epithelial cells and, if so, examined whether the suppression of MUC5AC gene ..
  8. Yamada N, Nishida Y, Yokoyama S, Tsutsumida H, Houjou I, Kitamoto S, et al. Expression of MUC5AC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells. J Hepatobiliary Pancreat Sci. 2010;17:844-54 pubmed publisher
    High de novo expression of MUC5AC (a gastric-type secreted mucin) is observed in many types of pancreatobiliary neoplasms, including precursor lesions...
  9. Hoshi H, Sawada T, Uchida M, Saito H, Iijima H, Toda Agetsuma M, et al. Tumor-associated MUC5AC stimulates in vivo tumorigenicity of human pancreatic cancer. Int J Oncol. 2011;38:619-27 pubmed publisher
    b>MUC5AC, a high molecular weight glycoprotein, is overexpressed in the ductal region of human pancreatic cancer but is not detectable in the normal pancreas, suggesting its association with disease development...
  10. Elsheikh M, Mahfouz M. Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric otitis media with effusion. Laryngoscope. 2006;116:365-9 pubmed
    ..We investigated the expression of MUC5AC and MUC5B mucin gene messenger (m)RNAs in middle ear effusions as well as in tissue biopsies of the respiratory ..
  11. Song K, Lee W, Chung K, Koo J, Yang E, Choi J, et al. Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells. J Biol Chem. 2003;278:23243-50 pubmed
    Mucin hypersecretion is commonly observed in many inflammatory diseases of the respiratory tract. MUC5AC is generally recognized to be a major airway mucin because MUC5AC is highly expressed in the goblet cells of human airway epithelium...
  12. Nordman H, Davies J, Lindell G, de Bolos C, Real F, Carlstedt I. Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution. Biochem J. 2002;364:191-200 pubmed
    Gastric MUC5AC and MUC6 mucins were studied using polyclonal antibodies. Immunohistochemistry showed MUC5AC to originate from the surface epithelium, whereas MUC6 was produced by the glands...
  13. Vinall L, Fowler J, Jones A, Kirkbride H, de Bolos C, Laine A, et al. Polymorphism of human mucin genes in chest disease: possible significance of MUC2. Am J Respir Cell Mol Biol. 2000;23:678-86 pubmed
    ..There was no significant difference in the distribution of alleles of MUC1, MUC4, MUC5AC, and MUC5B. MUC2, however, showed a highly significant difference in distribution...
  14. Koo J, Kim Y, Jetten A, Belloni P, Nettesheim P. Overexpression of mucin genes induced by interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor alpha antagonist. Exp Lung Res. 2002;28:315-32 pubmed
    ..In this study, we demonstrated that interleukin-1beta (IL-1beta) increased MUC2 and MUC5AC mRNA levels 2- to 3-fold in a time- and dose-dependent manner in NCI-H292 cells...
  15. Caramori G, Casolari P, Di Gregorio C, Saetta M, Baraldo S, Boschetto P, et al. MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients. Histopathology. 2009;55:321-31 pubmed publisher
    Mucus expectoration is a common feature of chronic obstructive pulmonary disease (COPD). MUC5AC and MUC5B, the major mucins, are released predominantly from submucosal glands in the central airways...
  16. Escande F, Aubert J, Porchet N, Buisine M. Human mucin gene MUC5AC: organization of its 5'-region and central repetitive region. Biochem J. 2001;358:763-72 pubmed
    Human mucin gene MUC5AC is clustered with MUC2, MUC5B and MUC6 on chromosome 11p15.5. We report here the full length cDNA sequence upstream of the repetitive region of human MUC5AC...
  17. Han L, Pansare V, Al Abbadi M, Husain M, Feng J. Combination of MUC5ac and WT-1 immunohistochemistry is useful in distinguishing pancreatic ductal carcinoma from ovarian serous carcinoma in effusion cytology. Diagn Cytopathol. 2010;38:333-6 pubmed publisher
    ..We evaluated the immunohistochemical staining of eight commercially available antibodies MUC1, MUC2, MUC5ac, Wilm's tumor susceptibility gene 1 (WT1), cytokeratin 7 (CK7), CK20, CA125, and CA19...
  18. Binker M, Binker Cosen A, Richards D, Oliver B, Cosen Binker L. LPS-stimulated MUC5AC production involves Rac1-dependent MMP-9 secretion and activation in NCI-H292 cells. Biochem Biophys Res Commun. 2009;386:124-9 pubmed publisher
    ..Previous studies have reported that lipopolysaccharides (LPS) stimulate mucin 5AC (MUC5AC) production via epidermal growth factor receptor (EGFR) in human airway cells...
  19. Guo X, Pace R, Stonebraker J, Commander C, Dang A, Drumm M, et al. Mucin variable number tandem repeat polymorphisms and severity of cystic fibrosis lung disease: significant association with MUC5AC. PLoS ONE. 2011;6:e25452 pubmed publisher
    ..by Southern blot or PCR to define variable number tandem repeat (VNTR) length polymorphisms for MUC1, MUC2, MUC5AC, and MUC7...
  20. Ha U, Lim J, Kim H, Wu W, Jin S, Xu H, et al. MKP1 regulates the induction of MUC5AC mucin by Streptococcus pneumoniae pneumolysin by inhibiting the PAK4-JNK signaling pathway. J Biol Chem. 2008;283:30624-31 pubmed publisher
    ..that the PAK4-JNK signaling pathway acted as a negative regulator for Streptococcus pneumoniae pneumolysin-induced MUC5AC mucin transcription...
  21. Di Y, Zhao J, Harper R. Cigarette smoke induces MUC5AC protein expression through the activation of Sp1. J Biol Chem. 2012;287:27948-58 pubmed publisher
    ..b>MUC5AC is the major inducible mucus gene in the airway...
  22. Kim G, Bae H, Park H, Kuan S, Crawley S, Ho J, et al. Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas. Gastroenterology. 2002;123:1052-60 pubmed
    ..This study examined alterations in the pattern and the level of expression of several mucin genes (MUC1, MUC2, MUC5AC, and MUC6) and mucin-associated tumor antigens (Nd2 and sialyl Tn) in these precursor lesions...
  23. Buisine M, Desseyn J, Porchet N, Degand P, Laine A, Aubert J. Genomic organization of the 3'-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family. Biochem J. 1998;332 ( Pt 3):729-38 pubmed
    The human mucin gene MUC5AC is mapped clustered with MUC2, MUC5B and MUC6 on chromosome 11p15.5...
  24. Baldus S, Monig S, Arkenau V, Hanisch F, Schneider P, Thiele J, et al. Correlation of MUC5AC immunoreactivity with histopathological subtypes and prognosis of gastric carcinoma. Ann Surg Oncol. 2002;9:887-93 pubmed
    b>MUC5AC represents a mucin peptide core expressed in normal gastric epithelia. Its presence in gastric carcinomas was previously described as a characteristic of gastric differentiation...
  25. Liu C, Li Q, Zhou X, Kolosov V, Perelman J. Rhythmic pressure waves induce mucin5AC expression via an EGFR-mediated signaling pathway in human airway epithelial cells. DNA Cell Biol. 2013;32:423-9 pubmed publisher
    ..As a major component of ASL, we speculated that the mucin5AC (MUC5AC) expression must also be regulated by RPW. However, fewer researches have focused on this question...
  26. Hewson C, Haas J, Bartlett N, Message S, Laza Stanca V, Kebadze T, et al. Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-?B and EGFR pathways. Eur Respir J. 2010;36:1425-35 pubmed publisher
    ..b>MUC5AC is the major mucin produced by bronchial epithelial cells...
  27. Nakao I, Kanaji S, Ohta S, Matsushita H, Arima K, Yuyama N, et al. Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease. J Immunol. 2008;180:6262-9 pubmed
    ..Pendrin induced expression of MUC5AC, a major product of mucus in asthma and COPD, in airway epithelial cells...
  28. Shin I, Park J, Shin N, Jeon C, Kwon O, Lee M, et al. Melatonin inhibits MUC5AC production via suppression of MAPK signaling in human airway epithelial cells. J Pineal Res. 2014;56:398-407 pubmed publisher
    ..In this study, we evaluated the effects of melatonin on the production of MUC5AC, a major constituent of the mucin that is secreted from the airway, using epidermal growth factor (EGF)-stimulated ..
  29. Gray T, Coakley R, Hirsh A, Thornton D, Kirkham S, Koo J, et al. Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1beta in human bronchial epithelia. Am J Physiol Lung Cell Mol Physiol. 2004;286:L320-30 pubmed
    ..Fully differentiated NHTBE cultures secreted two major airway mucins, MUC5AC and MUC5B. IL-1beta, in a dose- and time-dependent manner, increased the secretion of MUC5AC, but not MUC5B...
  30. Kettle R, Simmons J, Schindler F, Jones P, Dicker T, Dubois G, et al. Regulation of neuregulin 1beta1-induced MUC5AC and MUC5B expression in human airway epithelium. Am J Respir Cell Mol Biol. 2010;42:472-81 pubmed publisher
    ..The mucins, MUC5AC and MUC5B, contribute to the viscoelastic properties of mucus, and are found at elevated levels in the airways of ..
  31. Hasnain S, Evans C, Roy M, Gallagher A, Kindrachuk K, Barron L, et al. Muc5ac: a critical component mediating the rejection of enteric nematodes. J Exp Med. 2011;208:893-900 pubmed publisher
    De novo expression of Muc5ac, a mucin not normally expressed in the intestinal tract, is induced in the cecum of mice resistant to Trichuris muris infection...
  32. Van De Bovenkamp J, Mahdavi J, Korteland Van Male A, Büller H, Einerhand A, Boren T, et al. The MUC5AC glycoprotein is the primary receptor for Helicobacter pylori in the human stomach. Helicobacter. 2003;8:521-32 pubmed
    ..In infected patients, H. pylori colocalizes in situ with the gastric secretory mucin MUC5AC. The carbohydrate blood-group antigen Lewis B (LeB) was deemed responsible for the adherence of H...
  33. Huang Y, Mikami F, Jono H, Zhang W, Weng X, Koga T, et al. Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF. Biochem Biophys Res Commun. 2007;359:691-6 pubmed
    ..Despite extensive studies that focus on investigating how MUC5AC mucin is regulated by one inducer at a time, how MUC5AC is synergistically regulated by multiple factors remains ..
  34. Yu H, Li Q, Perelman J, Kolosov V, Zhou X. [Effects of endogeny polypeptide elafin on MUC5AC overexpression in human airway epithelial cells]. Zhonghua Jie He He Hu Xi Za Zhi. 2010;33:801-5 pubmed
    ..The levels of MUC5AC protein and mRNA were detected by ELISA and RT-PCR...
  35. Lee J, Shin N, Park J, Park S, Kwon O, Lee H, et al. Callicarpa japonica Thunb. attenuates cigarette smoke-induced neutrophil inflammation and mucus secretion. J Ethnopharmacol. 2015;175:1-8 pubmed publisher
    ..In in vitro experiment, we evaluated the effect of C. japonica Thunb. on the expression of MUC5AC and proinflammatory cytokines in H292 cells stimulated with CSC...
  36. Ding G, Zheng C, Liu Y, Tian J. [Roles of epidermal growth factor receptor signaling pathway on cultured human nasal epithelial cells RPMI-2650]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009;44:203-8 pubmed
    ..After incubated for 24 hours, the expression of EGFR and MUC5AC proteins in the cells of these 4 groups was studied using cytoimmunity and Western blotting...
  37. Round A, McMaster T, Miles M, Corfield A, Berry M. The isolated MUC5AC gene product from human ocular mucin displays intramolecular conformational heterogeneity. Glycobiology. 2007;17:578-85 pubmed
    ..work we have used affinity purification against the anti(mucin peptide core) monoclonal antibody 45M1 to isolate MUC5AC gene products, a major component of human ocular mucins...
  38. da Silva L, Boeing T, Somensi L, Cury B, Steimbach V, Silveria A, et al. Evidence of gastric ulcer healing activity of Maytenus robusta Reissek: In vitro and in vivo studies. J Ethnopharmacol. 2015;175:75-85 pubmed publisher
    ..Moreover, HEMR treatment increased gastric mucin content and reduced oxidative stress and inflammatory parameters at the site of the ulcer...
  39. Carmona Vicente N, Allen D, Rodriguez Diaz J, Iturriza Gomara M, Buesa J. Antibodies against Lewis antigens inhibit the binding of human norovirus GII.4 virus-like particles to saliva but not to intestinal Caco-2 cells. Virol J. 2016;13:82 pubmed publisher
    ..1 genotype and from three GII.4 genotype variants, GII.4-1999, GII.4-2004 and GII.4-2006b, to bind to porcine gastric mucin (PGM), human saliva and differentiated human intestinal Caco-2 cells (D-Caco-2 cells)...
  40. Yoo K, Choi H, Jun D, Lee H, Lee O, Yoon B, et al. MUC Expression in Gallbladder Epithelial Tissues in Cholesterol-Associated Gallbladder Disease. Gut Liver. 2016;10:851-8 pubmed publisher
    ..Canine GBECs treated with lipopolysaccharide were also studied. MUC3, MUC5AC, MUC5B, and MUC6 antibodies were used for dot/slot immunoblotting and immunohistochemical studies of the ..
  41. Kuscher S, Steinle H, Soleiman A, Ofner D, Schneeberger S, Oberhuber G. Intraductal tubulopapillary neoplasm (ITPN) of the pancreas associated with an invasive component: a case report with review of the literature. World J Surg Oncol. 2017;15:203 pubmed publisher
    ..negative for synaptophysin and chromogranin A, CDx2, CK20, S100, carcinoembryonic antigen (CEA), MUC 2, MUC5AC, and somatostatin; and in part positive for CA19-9...
  42. Yao Q, Zhu M, Chen J, Shao C, Yan C, Wang Z, et al. Reconstruction of conjunctival epithelium-like tissue using a temperature-responsive culture dish. Mol Vis. 2015;21:1113-21 pubmed
    ..Immunohistochemistry for CK4, CK19, and MUC5AC showed the cell sheets still maintained characteristics of the conjunctival epithelium...
  43. Zhang Y, Zhu M, Yang Z, Pan X, Jiang Y, Sun C, et al. The human Cathelicidin LL-37 induces MUC5AC mucin production by airway epithelial cells via TACE-TGF-?-EGFR pathway. Exp Lung Res. 2014;40:333-42 pubmed publisher
    To investigate the mechanism for LL-37 inducing MUC5AC mucin production in airway epithelial cells...
  44. Tomasetto C, Masson R, Linares J, Wendling C, Lefebvre O, Chenard M, et al. pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins. Gastroenterology. 2000;118:70-80 pubmed
    ..sequences encoding carboxy-terminal fragments of mMuc2 (489 residues) and mMuc5AC (427, 430, and 894 residues) mucin proteins...
  45. Jinfeng M, Kimura W, Hirai I, Sakurai F, Moriya T, Mizutani M. Expression of MUC5AC and MUC6 in invasive ductal carcinoma of the pancreas and relationship with prognosis. Int J Gastrointest Cancer. 2003;34:9-18 pubmed
    b>MUC5AC and MUC6 are two major types of mucin that are abundantly present in the stomach; both of them form a gel of high viscosity that provides protection and lubrication...
  46. Liu C, Li Q, Zhou X. [Inhibition of suppressor of cytokine signaling 1 on lipopolysaccharide-induced mucin5AC hypersecretion and the mechanism in human bronchial epithelial cells]. Zhonghua Yi Xue Za Zhi. 2016;96:966-70 pubmed publisher
    ..the inhibitory role of suppressor of cytokine signaling 1 (SOCS1) in lipopolysaccharide (LPS)-induced mucin5AC (MUC5AC) hypersecretion and the potential mechanism involved in this process...
  47. Danese E, Ruzzenente O, Ruzzenente A, Iacono C, Bertuzzo F, Gelati M, et al. Assessment of bile and serum mucin5AC in cholangiocarcinoma: diagnostic performance and biologic significance. Surgery. 2014;156:1218-24 pubmed publisher
    Recent studies have showed the efficacy of mucin5AC (MUC5AC) as a diagnostic and prognostic serum biomarker in biliary tract tumors...
  48. Xu R, Li Q, Zhou J, Zhou X, Perelman J, Kolosov V. Secretoneurin induces airway mucus hypersecretion by enhancing the binding of EGF to NRP1. Cell Physiol Biochem. 2014;33:446-56 pubmed publisher
    ..qPCR) and enzyme-linked immuno sorbent assay (ELISA) respectively, the intracellular mucin(MUC)5AC mRNA and MUC5AC protein of culture supernates exhibited a time- and dose-dependent increase after stimulation of SN...
  49. Debailleul V, Laine A, Huet G, Mathon P, d Hooghe M, Aubert J, et al. Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs. J Biol Chem. 1998;273:881-90 pubmed
    Of the nine mucin genes that have been characterized, only MUC1 and MUC7 have been fully sequenced, and their transcripts can be detected as distinct bands of predicted size by Northern blot analysis...
  50. Xu H, Sun Q, Lu L, Luo F, Zhou L, Liu J, et al. MicroRNA-218 acts by repressing TNFR1-mediated activation of NF-?B, which is involved in MUC5AC hyper-production and inflammation in smoking-induced bronchiolitis of COPD. Toxicol Lett. 2017;280:171-180 pubmed publisher
    ..bronchial epithelial (HBE) cells, cigarette smoke extract (CSE) decreased miR-218 levels and increased levels of MUC5AC, interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor receptor 1 (TNFR1), and p-p65...
  51. Basturk O, Chung S, Hruban R, Adsay N, Askan G, Iacobuzio Donahue C, et al. Distinct pathways of pathogenesis of intraductal oncocytic papillary neoplasms and intraductal papillary mucinous neoplasms of the pancreas. Virchows Arch. 2016;469:523-532 pubmed
    ..SMAD4/?-catenin/p53/mesothelin/claudin-4) as well as antibodies to mucins and differentiation markers [MUC1/MUC2/MUC5AC/MUC6/CDX2/hepatocyte paraffin-1 (HepPar-1)] was investigated in 24 IOPNs and 22 IPMNs to assess the similarities/..
  52. Kasashima S, Kawashima A, Zen Y, Ozaki S, Kobayashi M, Tsujibata A, et al. Expression of aberrant mucins in lobular carcinoma with histiocytoid feature of the breast. Virchows Arch. 2007;450:397-403 pubmed
    ..were significantly different between the two groups: a fair number of HLC cases were immunopositive for MUC2 and MUC5AC (75 and 50%, respectively); in contrast, almost all CLC cases showed both as negative...
  53. Ho J, Han S, Pan P, Deng G, Kuan S, Kim Y. Methylation status of promoters and expression of MUC2 and MUC5AC mucins in pancreatic cancer cells. Int J Oncol. 2003;22:273-9 pubmed
    ..MUC2 and MUC5AC are not expressed in normal pancreas...
  54. Sale M, Chen W, Weeks D, Mychaleckyj J, Hou X, Marion M, et al. Evaluation of 15 functional candidate genes for association with chronic otitis media with effusion and/or recurrent otitis media (COME/ROM). PLoS ONE. 2011;6:e22297 pubmed publisher
    ..SNP rs2735733 in the region of the mucin 5, subtypes A/C gene (MUC5AC) exhibited nominal evidence for association with COME/ROM (P?=?0.002)...
  55. Hebbar V, Damera G, Sachdev G. Differential expression of MUC genes in endometrial and cervical tissues and tumors. BMC Cancer. 2005;5:124 pubmed
    ..The objective of this study was to investigate the expression of human MUC genes (MUC1, MUC2, MUC5B, MUC5AC and MUC8) in human endometrium and cervix, and to compare and quantitate the expression of MUC genes in normal and ..
  56. Lidell M, Hansson G. Cleavage in the GDPH sequence of the C-terminal cysteine-rich part of the human MUC5AC mucin. Biochem J. 2006;399:121-9 pubmed
    b>MUC5AC is the main gel-forming mucin expressed by goblet cells of the airways and stomach where it protects the underlying epithelia...
  57. Wang J, El Bahrawy M. Expression profile of mucins (MUC1, MUC2, MUC5AC, and MUC6) in ovarian mucinous tumours: changes in expression from benign to malignant tumours. Histopathology. 2015;66:529-35 pubmed publisher
    ..MUC1, MUC2, MUC5AC and MUC6 expression was studied by immunohistochemistry in 53 OMTs (19 malignant, 25 borderline, and nine benign)...
  58. Han W, Du X, Wang J, Sun L, Li Y. SNHG16 indicates a poor prognosis and affects cell proliferation, migration and invasion in non-small cell lung cancer. Exp Cell Res. 2017;: pubmed publisher
    ..Subsequently, MUC5AC, a major mucin in the human respiratory tract correlated with post-operative metastasis and recurrence of NSCLC, ..
  59. Kesimer M, Ford A, Ceppe A, Radicioni G, Cao R, Davis C, et al. Airway Mucin Concentration as a Marker of Chronic Bronchitis. N Engl J Med. 2017;377:911-922 pubmed publisher
    ..In 148 of these participants, the respiratory secreted mucins MUC5AC and MUC5B were quantitated by means of mass spectrometry...
  60. Sibila O, Garcia Bellmunt L, Giner J, Rodrigo Troyano A, Suarez Cuartin G, Torrego A, et al. Airway Mucin 2 Is Decreased in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization. Ann Am Thorac Soc. 2016;13:636-42 pubmed publisher
    ..Patients with bronchiectasis were excluded. Secreted mucins (MUC2, MUC5AC, and MUC5B) and inflammatory markers were assessed in BAL and sputum by ELISA...
  61. Yu X, Rong W, Xu F, Xu G, Sun Y, Feng M. [Expression and clinical significance of Mucin and E-cadherin in colorectal tumors]. Ai Zheng. 2007;26:1204-10 pubmed
    ..This study was to investigate the expression of MUC1, MUC2, MUC5AC and E-cad in different colorectal tumor tissues, and explore their correlations to clinicopathologic features of ..
  62. Zhou X, Tu J, Li Q, Kolosov V, Perelman J. Hypoxia induces mucin expression and secretion in human bronchial epithelial cells. Transl Res. 2012;160:419-27 pubmed publisher
    ..objective was to investigate the role of hypoxia-inducible factor 1 (HIF-1) in the transcriptional activation of MUC5AC in human bronchial epithelial (HBE) 16 cells under hypoxia conditions and the effect of hypoxia on expression and ..
  63. Sanada Y, Yoshida K, Ohara M, Oeda M, Konishi K, Tsutani Y. Histopathologic evaluation of stepwise progression of pancreatic carcinoma with immunohistochemical analysis of gastric epithelial transcription factor SOX2: comparison of expression patterns between invasive components and cancerous or nonneoplastic. Pancreas. 2006;32:164-70 pubmed
    ..study was to perform histopathologic and immunohistochemical analyses of gastric transcription factor SOX2 and gastric mucin MUC5AC to better understand the stepwise progression of pancreatic carcinoma...
  64. Kingsley D, Fay J, Calci K, Pouillot R, Woods J, Chen H, et al. Evaluation of Chlorine Treatment Levels for Inactivation of Human Norovirus and MS2 Bacteriophage during Sewage Treatment. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..1 and GII.4 by chlorine under conditions mimicking sewage treatment. Using a porcine gastric mucin-magnetic bead (PGM-MB) assay, no statistically significant loss in HuNoV binding (inactivation) was observed ..
  65. Aceves S, Ackerman S. Relationships between eosinophilic inflammation, tissue remodeling, and fibrosis in eosinophilic esophagitis. Immunol Allergy Clin North Am. 2009;29:197-211, xiii-xiv pubmed publisher
    ..Current and potential therapeutic interventions are discussed that may impact the development or resolution of chronic esophageal remodeling and fibrosis in EE. ..
  66. Xu Q, Chen L, Ran D, Xie W, Li Q, Zhou X. Bombesin receptor-activated protein regulates neutrophil elastase-induced mucin5AC hypersecretion in human bronchial epithelial cells. Exp Cell Res. 2017;357:145-154 pubmed publisher
    ..Neutrophil elastase (NE) is a potent inducer of mucin5AC (MUC5AC), which is considered the predominant mucin secreted by human airway epithelial cells...
  67. Agnifili L, Fasanella V, Mastropasqua R, Frezzotti P, Curcio C, Brescia L, et al. In Vivo Goblet Cell Density as a Potential Indicator of Glaucoma Filtration Surgery Outcome. Invest Ophthalmol Vis Sci. 2016;57:2928–2935 pubmed publisher
    We analyzed the preoperative conjunctival goblet cell density (GCD), MUC5AC, and HLA-DR in glaucomatous patients undergoing trabeculectomy, using laser scanning confocal microscopy (LSCM) and impression cytology (IC)...
  68. Fischer B, Voynow J. Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species. Am J Respir Cell Mol Biol. 2002;26:447-52 pubmed
    ..We previously reported that neutrophil elastase increases expression of a major respiratory mucin gene, MUC5AC, by enhancing mRNA stability...
  69. Sheehan J, Kirkham S, Howard M, Woodman P, Kutay S, Brazeau C, et al. Identification of molecular intermediates in the assembly pathway of the MUC5AC mucin. J Biol Chem. 2004;279:15698-705 pubmed
    b>MUC5AC mucins secreted by HT-29 cells in culture are oligomeric glycoproteins with characteristics similar to the MUC5AC mucins isolated from human airway sputum (Sheehan, J. K., Brazeau, C., Kutay, S., Pigeon, H., Kirkham, S., Howard, M...
  70. Eom D, Hong S, Kim J, Kim G, Bae Y, Jang K, et al. Notch3 signaling is associated with MUC5AC expression and favorable prognosis in patients with small intestinal adenocarcinomas. Pathol Res Pract. 2014;210:501-7 pubmed publisher
    ..Surgically resected 191 SIACs and their clinical data were collected. Immunohistochemistry for Notch3, MUC2, MUC5AC, and MUC6 using tissue microarrays from formalin-fixed paraffin-embedded normal and matched tumor tissues was ..
  71. Im G, Park M, Song J. Effect of urban particles on human middle ear epithelial cells. Int J Pediatr Otorhinolaryngol. 2014;78:777-81 pubmed publisher
    ..The expression levels of the inflammation-related genes (COX-2 and MUC5AC) were analyzed using semi-quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) and COX-..
  72. Kondo T, Hashi A, Murata S, Fischer S, Nara M, Nakazawa T, et al. Gastric mucin is expressed in a subset of endocervical tunnel clusters: type A tunnel clusters of gastric phenotype. Histopathology. 2007;50:843-50 pubmed
    b>Gastric mucin expression has been demonstrated in a group of endocervical glandular lesions. The aim of this study was to gain further insight into endocervical lesions with a gastric phenotype...
  73. Lee S, Sung M, Ryu H, Lee J, Kim H, In H, et al. Verproside inhibits TNF-α-induced MUC5AC expression through suppression of the TNF-α/NF-κB pathway in human airway epithelial cells. Cytokine. 2016;77:168-75 pubmed publisher
    ..However, overproduction and hypersecretion of mucus, mainly composed of MUC5AC, are significant risk factors in asthma and chronic obstructive pulmonary disease (COPD) patients...