MUC4

Summary

Gene Symbol: MUC4
Description: mucin 4, cell surface associated
Alias: ASGP, HSA276359, MUC-4, mucin-4, ascites sialoglycoprotein, mucin 4, tracheobronchial, pancreatic adenocarcinoma mucin, testis mucin, tracheobronchial mucin
Species: human
Products:     MUC4

Top Publications

  1. Davidson B, Baekelandt M, Shih I. MUC4 is upregulated in ovarian carcinoma effusions and differentiates carcinoma cells from mesothelial cells. Diagn Cytopathol. 2007;35:756-60 pubmed
    Using gene expression arrays, we recently showed that MUC4 expression is significantly higher in ovarian/primary peritoneal serous carcinoma (OC/PPC) compared to diffuse peritoneal malignant mesothelioma (DMPM)...
  2. Moniaux N, Nollet S, Porchet N, Degand P, Laine A, Aubert J. Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin. Biochem J. 1999;338 ( Pt 2):325-33 pubmed
    ..SMC is a heterodimeric glycoprotein complex composed of mucin (ascites sialoglycoprotein 1, ASGP-1) and transmembrane (ASGP-2) subunits...
  3. Moniaux N, Escande F, Batra S, Porchet N, Laine A, Aubert J. Alternative splicing generates a family of putative secreted and membrane-associated MUC4 mucins. Eur J Biochem. 2000;267:4536-44 pubmed
    The MUC4 mucin gene encodes a putative membrane-anchored mucin with predicted size of 930 kDa, for its 26.5-kb allele...
  4. Chauhan S, Singh A, Ruiz F, Johansson S, Jain M, Smith L, et al. Aberrant expression of MUC4 in ovarian carcinoma: diagnostic significance alone and in combination with MUC1 and MUC16 (CA125). Mod Pathol. 2006;19:1386-94 pubmed
    ..Here, we have analyzed the expression of MUC4 and have compared its potential usefulness in early detection and prognosis of ovarian carcinoma alone and in ..
  5. Koscinski I, Viville S, Porchet N, Bernigaud A, Escande F, Defossez A, et al. MUC4 gene polymorphism and expression in women with implantation failure. Hum Reprod. 2006;21:2238-45 pubmed
    The molecular mechanism of human embryo implantation is poorly understood. The role of MUC4 mucin, present in endometrial epithelium, has never been explored, and results obtained in animal studies strongly suggest a role in implantation...
  6. Gross M, Guyonnet Duperat V, Porchet N, Bernheim A, Aubert J, Nguyen V. Mucin 4 (MUC4) gene: regional assignment (3q29) and RFLP analysis. Ann Genet. 1992;35:21-6 pubmed
    The use of a probe (JER64) containing a mucin 4 (MUC4) cDNA insert of 1.83 kb allowed to assign by in situ hybridization, the MUC4 gene to 3q29...
  7. Yamada N, Nishida Y, Tsutsumida H, Goto M, Higashi M, Nomoto M, et al. Promoter CpG methylation in cancer cells contributes to the regulation of MUC4. Br J Cancer. 2009;100:344-51 pubmed publisher
    b>Mucin 4 (MUC4) is a high molecular weight transmembrane mucin that is overexpressed in many carcinomas and is a risk factor associated with a poor prognosis...
  8. Nam K, Noh T, Chung S, Lee S, Lee M, Hong S, et al. Expression of the membrane mucins MUC4 and MUC15, potential markers of malignancy and prognosis, in papillary thyroid carcinoma. Thyroid. 2011;21:745-50 pubmed publisher
    ..The aim of this study was to evaluate the expression levels of MUC4, MUC15, MMP-13, and TIMP-3 and their prognostic significance in PTC...
  9. Ponnusamy M, Singh A, Jain M, Chakraborty S, Moniaux N, Batra S. MUC4 activates HER2 signalling and enhances the motility of human ovarian cancer cells. Br J Cancer. 2008;99:520-6 pubmed publisher
    The mucin MUC4 is a high molecular weight transmembrane glycoprotein. It consists of a mucin-type subunit (MUC4alpha) and a transmembrane growth factor-like subunit (MUC4beta)...

More Information

Publications72

  1. Chaturvedi P, Singh A, Moniaux N, Senapati S, Chakraborty S, Meza J, et al. MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins. Mol Cancer Res. 2007;5:309-20 pubmed
    b>MUC4, a transmembrane mucin, is aberrantly expressed in pancreatic adenocarcinomas while remaining undetectable in the normal pancreas...
  2. Senapati S, Gnanapragassam V, Moniaux N, Momi N, Batra S. Role of MUC4-NIDO domain in the MUC4-mediated metastasis of pancreatic cancer cells. Oncogene. 2012;31:3346-56 pubmed publisher
    b>MUC4 is a large transmembrane type I glycoprotein that is overexpressed in pancreatic cancer (PC) and has been shown to be associated with its progression and metastasis...
  3. Funes M, Miller J, Lai C, Carraway K, Sweeney C. The mucin Muc4 potentiates neuregulin signaling by increasing the cell-surface populations of ErbB2 and ErbB3. J Biol Chem. 2006;281:19310-9 pubmed
    ..We have previously demonstrated that Muc4, a transmembrane mucin that promotes tumor growth and metastasis, physically interacts with the ErbB2 receptor ..
  4. Ramsauer V, Pino V, Farooq A, Carothers Carraway C, Salas P, Carraway K. Muc4-ErbB2 complex formation and signaling in polarized CACO-2 epithelial cells indicate that Muc4 acts as an unorthodox ligand for ErbB2. Mol Biol Cell. 2006;17:2931-41 pubmed
    b>Muc4 serves as an intramembrane ligand for the receptor tyrosine kinase ErbB2...
  5. Saitou M, Goto M, Horinouchi M, Tamada S, Nagata K, Hamada T, et al. MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas. J Clin Pathol. 2005;58:845-52 pubmed
    Many patients with invasive ductal carcinoma of the pancreas (IDC) have a poor outcome. MUC4 expression has been implicated as a marker for diagnosis and progression of IDC, but there are no studies of the relation between MUC4 expression ..
  6. Mukhopadhyay P, Lakshmanan I, Ponnusamy M, Chakraborty S, Jain M, Pai P, et al. MUC4 overexpression augments cell migration and metastasis through EGFR family proteins in triple negative breast cancer cells. PLoS ONE. 2013;8:e54455 pubmed publisher
    ..Emerging evidence suggests that MUC4 mucin is associated with metastasis of various cancers, including breast cancer...
  7. Jepson S, Komatsu M, Haq B, Arango M, Huang D, Carraway C, et al. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways. Oncogene. 2002;21:7524-32 pubmed
    b>Muc4/sialomucin complex (SMC) is a multifunctional glycoprotein complex which can repress apoptosis in transfected tumor cells...
  8. Remmers N, Anderson J, Linde E, Dimaio D, Lazenby A, Wandall H, et al. Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer. Clin Cancer Res. 2013;19:1981-93 pubmed publisher
    ..There were significant changes in mucin expression patterns throughout disease progression. MUC1 and MUC4 were differentially glycosylated as the disease progressed from early pancreatic intraepithelial neoplasias to ..
  9. Yokoyama A, Shi B, Kawai T, Konishi H, Andoh R, Tachikawa H, et al. Muc4 is required for activation of ErbB2 in signet ring carcinoma cell lines. Biochem Biophys Res Commun. 2007;355:200-3 pubmed
    ..However, the mechanism underlying this activation has not been understood. Here, we show that ErbB2 and Muc4 bind in signet ring carcinoma cells, which was not seen in highly differentiated adenocarcinoma cell lines...
  10. Bafna S, Kaur S, Momi N, Batra S. Pancreatic cancer cells resistance to gemcitabine: the role of MUC4 mucin. Br J Cancer. 2009;101:1155-61 pubmed publisher
    ..The MUC4 transmembrane glycoprotein is aberrantly overexpressed in the pancreatic cancer and recently, has been shown to ..
  11. Hamada T, Wakamatsu T, Miyahara M, Nagata S, Nomura M, Kamikawa Y, et al. MUC4: a novel prognostic factor of oral squamous cell carcinoma. Int J Cancer. 2012;130:1768-76 pubmed publisher
    b>MUC4 mucin is now known to be expressed in various normal and cancer tissues...
  12. Audie J, Janin A, Porchet N, Copin M, Gosselin B, Aubert J. Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization. J Histochem Cytochem. 1993;41:1479-85 pubmed
    ..The choice of oligonucleotide probes was made to amplify the signal by hybridization of many small probes on the same mRNA molecules. A characteristic pattern of mucin gene expression was observed for each mucosa. ..
  13. Mejías Luque R, Peiro S, Vincent A, Van Seuningen I, de Bolos C. IL-6 induces MUC4 expression through gp130/STAT3 pathway in gastric cancer cell lines. Biochim Biophys Acta. 2008;1783:1728-36 pubmed publisher
    ..pylori-infected subjects and, in gastric adenocarcinomas, the up-regulation of intestinal mucin genes (MUC2 and MUC4) has been detected...
  14. Vincent A, Ducourouble M, Van Seuningen I. Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases. FASEB J. 2008;22:3035-45 pubmed publisher
    The human gene MUC4 encodes a transmembrane mucin, ligand of ErbB2, that is associated with pancreatic tumor progression...
  15. Chaturvedi P, Singh A, Chakraborty S, Chauhan S, Bafna S, Meza J, et al. MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells. Cancer Res. 2008;68:2065-70 pubmed publisher
    b>MUC4, a high-molecular weight transmembrane glycoprotein, is overexpressed in pancreatic cancer and is implicated in its pathogenesis...
  16. Nollet S, Moniaux N, Maury J, Petitprez D, Degand P, Laine A, et al. Human mucin gene MUC4: organization of its 5'-region and polymorphism of its central tandem repeat array. Biochem J. 1998;332 ( Pt 3):739-48 pubmed
    ..This latter shows a high degree of similarity to the signal peptide of another apomucin, ASGP-1. Exon 2 is extremely large and contains a unique sequence that is followed by the whole tandem repeat domain...
  17. Piessen G, Jonckheere N, Vincent A, Hemon B, Ducourouble M, Copin M, et al. Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1alpha. Biochem J. 2007;402:81-91 pubmed
    MUC4 (mucin 4) is a membrane-bound mucin overexpressed in the early steps of oesophageal carcinogenesis and implicated in tumour progression...
  18. Pino V, Ramsauer V, Salas P, Carothers Carraway C, Carraway K. Membrane mucin Muc4 induces density-dependent changes in ERK activation in mammary epithelial and tumor cells: role in reversal of contact inhibition. J Biol Chem. 2006;281:29411-20 pubmed
    The membrane mucin Muc4 has been shown to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for the receptor tyrosine ..
  19. Lopez Ferrer A, Alameda F, Barranco C, Garrido M, de Bolos C. MUC4 expression is increased in dysplastic cervical disorders. Hum Pathol. 2001;32:1197-202 pubmed
    ..Among human mucin genes, the MUC4 sequence has a transmembrane domain, and its molecular structure suggests that it has a protective role and also ..
  20. Zhang J, Perez A, Yasin M, Soto P, Rong M, Theodoropoulos G, et al. Presence of MUC4 in human milk and at the luminal surfaces of blood vessels. J Cell Physiol. 2005;204:166-77 pubmed
    MUC4 is a heterodimeric membrane mucin, composed of a mucin subunit ASGP-1 (MUC4alpha) and a transmembrane subunit ASGP-2 (MUC4beta), which has been implicated in the protection of epithelial cell surfaces...
  21. Andrianifahanana M, Agrawal A, Singh A, Moniaux N, Van Seuningen I, Aubert J, et al. Synergistic induction of the MUC4 mucin gene by interferon-gamma and retinoic acid in human pancreatic tumour cells involves a reprogramming of signalling pathways. Oncogene. 2005;24:6143-54 pubmed
    The transmembrane mucin, MUC4, is aberrantly expressed with a high incidence in human pancreatic adenocarcinomas and plays an important role in the pathogenesis of the disease...
  22. Kitazono I, Higashi M, Kitamoto S, Yokoyama S, Horinouchi M, Osako M, et al. Expression of MUC4 mucin is observed mainly in the intestinal type of intraductal papillary mucinous neoplasm of the pancreas. Pancreas. 2013;42:1120-8 pubmed publisher
    This study aimed to examine expression profile of MUC4 in intraductal papillary mucinous neoplasm of the pancreas (IPMN).
  23. Singh A, Chauhan S, Andrianifahanana M, Moniaux N, Meza J, Copin M, et al. MUC4 expression is regulated by cystic fibrosis transmembrane conductance regulator in pancreatic adenocarcinoma cells via transcriptional and post-translational mechanisms. Oncogene. 2007;26:30-41 pubmed
    b>MUC4 mucin is a high molecular weight transmembrane glycoprotein that plays important roles in tumour biology. It is aberrantly expressed in pancreatic adenocarcinoma, while not being detectable in the normal pancreas...
  24. Carraway K, Perez A, Idris N, Jepson S, Arango M, Komatsu M, et al. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive. Prog Nucleic Acid Res Mol Biol. 2002;71:149-85 pubmed
    The membrane mucin Muc4, also called sialomucin complex (SMC), is a heterodimeric complex of two subunits, ASGP-1 and ASGP-2, derived from a single gene...
  25. Miyahara N, Shoda J, Ishige K, Kawamoto T, Ueda T, Taki R, et al. MUC4 interacts with ErbB2 in human gallbladder carcinoma: potential pathobiological implications. Eur J Cancer. 2008;44:1048-56 pubmed publisher
    b>Muc4 interacts with erbB2 and potentiates tumourigenesis and/or tumour growth...
  26. Ramsauer V, Carraway C, Salas P, Carraway K. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, translocates ErbB2 to the apical surface in polarized epithelial cells. J Biol Chem. 2003;278:30142-7 pubmed
    b>Muc4/Sialomucin complex (SMC) acts as an intramembrane ligand for the receptor tyrosine kinase ErbB2, inducing a limited phosphorylation of the receptor...
  27. Desseyn J, Clavereau I, Laine A. Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4. Eur J Biochem. 2002;269:3150-9 pubmed
    ..16, which is the orthologous region of human chromosome 3q29 encompassing the large membrane-anchored mucin MUC4. Contigs analysis of the Human Genome Project did not reveal any other mucin on chromosome 3q29 and, interestingly, ..
  28. Alos L, Lujan B, Castillo M, Nadal A, Carreras M, Caballero M, et al. Expression of membrane-bound mucins (MUC1 and MUC4) and secreted mucins (MUC2, MUC5AC, MUC5B, MUC6 and MUC7) in mucoepidermoid carcinomas of salivary glands. Am J Surg Pathol. 2005;29:806-13 pubmed
    ..The aim of this study was to investigate the expression of mucins (MUC1, MUC2, MUC4, MUC5AC, MUCB, MUC6, MUC7) in mucoepidermoid carcinomas, the most frequent malignant tumor of salivary glands...
  29. Audie J, Tetaert D, Pigny P, Buisine M, Janin A, Aubert J, et al. Mucin gene expression in the human endocervix. Hum Reprod. 1995;10:98-102 pubmed
    In the human uterine endocervix, five out of the six human mucin genes investigated (MUC 2, MUC 3, MUC 4, MUC 5AC, MUC 5B and MUC 6) are expressed, whereas in some other mucosae the hybridization pattern demonstrates the expression of ..
  30. Bafna S, Singh A, Moniaux N, Eudy J, Meza J, Batra S. MUC4, a multifunctional transmembrane glycoprotein, induces oncogenic transformation of NIH3T3 mouse fibroblast cells. Cancer Res. 2008;68:9231-8 pubmed publisher
    Numerous studies have established the association of MUC4 with the progression of cancer and metastasis...
  31. Theodoropoulos G, Carraway C, Carraway K. MUC4 involvement in ErbB2/ErbB3 phosphorylation and signaling in response to airway cell mechanical injury. J Cell Biochem. 2009;107:112-22 pubmed publisher
    ..Since we have shown that the membrane mucin MUC4 can act as a ligand/modulator for ErbB2, affecting its localization in polarized epithelial cells and its ..
  32. Choudhury A, Moniaux N, Winpenny J, Hollingsworth M, Aubert J, Batra S. Human MUC4 mucin cDNA and its variants in pancreatic carcinoma. J Biochem. 2000;128:233-43 pubmed
    The human MUC4 gene is not expressed in normal pancreas; however, its dysregulation results in high levels of expression in pancreatic tumors...
  33. Chen A, Migliaccio I, Rimawi M, López Tarruella S, Creighton C, Massarweh S, et al. Upregulation of mucin4 in ER-positive/HER2-overexpressing breast cancer xenografts with acquired resistance to endocrine and HER2-targeted therapies. Breast Cancer Res Treat. 2012;134:583-93 pubmed publisher
    ..RNA extracted from tumors at early time points and late after acquired resistance were analyzed for mucin4 (MUC4) expression by microarray and quantitative reverse transcriptase-PCR...
  34. Porchet N, Nguyen V, Dufosse J, Audie J, Guyonnet Duperat V, Gross M, et al. Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs. Biochem Biophys Res Commun. 1991;175:414-22 pubmed
    ..This clone hybridized to polydisperse messages produced by human tracheo-bronchial and human colonic mucosae. The gene (proposed name MUC 4) from which cDNA is derived maps to chromosome 3.
  35. Ponnusamy M, Lakshmanan I, Jain M, Das S, Chakraborty S, Dey P, et al. MUC4 mucin-induced epithelial to mesenchymal transition: a novel mechanism for metastasis of human ovarian cancer cells. Oncogene. 2010;29:5741-54 pubmed publisher
    ..The MUC4 mucin is overexpressed in ovarian tumors and has a role in the invasiveness of OC cells...
  36. Westgaard A, Schjølberg A, Cvancarova M, Eide T, Clausen O, Gladhaug I. Differentiation markers in pancreatic head adenocarcinomas: MUC1 and MUC4 expression indicates poor prognosis in pancreatobiliary differentiated tumours. Histopathology. 2009;54:337-47 pubmed publisher
    ..Immunohistochemistry for cytokeratin (CK) 7, CK20, MUC1, MUC2, MUC4 and CDX2 was performed on tissue microarrays...
  37. Gipson I, Spurr Michaud S, Moccia R, Zhan Q, Toribara N, Ho S, et al. MUC4 and MUC5B transcripts are the prevalent mucin messenger ribonucleic acids of the human endocervix. Biol Reprod. 1999;60:58-64 pubmed
    ..Three large gel-forming mucins, MUCs 5AC, 5B, and 6, are expressed by the endocervical epithelium, as is MUC4, a relatively uncharacterized mucin for which only tandem repeat sequence has been reported...
  38. Singh A, Moniaux N, Chauhan S, Meza J, Batra S. Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis. Cancer Res. 2004;64:622-30 pubmed
    The MUC4 mucin is a high molecular weight membrane-bound glycoprotein. It is aberrantly expressed in pancreatic tumors and tumor cell lines with no detectable expression in the normal pancreas...
  39. Jonckheere N, Perrais M, Mariette C, Batra S, Aubert J, Pigny P, et al. A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-beta in pancreatic carcinogenesis. Oncogene. 2004;23:5729-38 pubmed
    b>MUC4: encodes a large transmembrane mucin that is overexpressed in pancreatic adenocarcinomas. The molecular mechanisms responsible for that altered pattern of expression are unknown...
  40. Singh A, Chauhan S, Bafna S, Johansson S, Smith L, Moniaux N, et al. Aberrant expression of transmembrane mucins, MUC1 and MUC4, in human prostate carcinomas. Prostate. 2006;66:421-9 pubmed
    ..Recent findings have provided substantial evidence for the involvement of transmembrane mucins, MUC1 and MUC4, in altered cell signaling, tumor growth, and metastasis...
  41. Senapati S, Chaturvedi P, Sharma P, Venkatraman G, Meza J, el Rifai W, et al. Deregulation of MUC4 in gastric adenocarcinoma: potential pathobiological implication in poorly differentiated non-signet ring cell type gastric cancer. Br J Cancer. 2008;99:949-56 pubmed publisher
    b>MUC4 is a large, heavily glycosylated transmembrane mucin, that is implicated in the pathogenesis of various types of cancers...
  42. Tamada S, Shibahara H, Higashi M, Goto M, Batra S, Imai K, et al. MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma. Clin Cancer Res. 2006;12:4257-64 pubmed
    Many of the patients with extrahepatic bile duct carcinoma (EHBDC) show a poor outcome. We have reported that MUC4 is a novel prognostic factor of pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma...
  43. Carrara S, Cangi M, Arcidiacono P, Perri F, Petrone M, Mezzi G, et al. Mucin expression pattern in pancreatic diseases: findings from EUS-guided fine-needle aspiration biopsies. Am J Gastroenterol. 2011;106:1359-63 pubmed publisher
    ..assess the expression pattern of MUCs by reverse transcription-PCR with primers specific for the MUC1, MUC2, MUC3, MUC4, MUC5A, MUC5B, MUC6, and MUC7 genes. RNA extraction was successful in 81% of the biopsies...
  44. Sierzega M, Młynarski D, Tomaszewska R, Kulig J. Semiquantitative immunohistochemistry for mucin (MUC1, MUC2, MUC3, MUC4, MUC5AC, and MUC6) profiling of pancreatic ductal cell adenocarcinoma improves diagnostic and prognostic performance. Histopathology. 2016;69:582-91 pubmed publisher
    ..A diagnostic model was developed for MUC QS (MUC1, MUC2, MUC3, MUC4, MUC5AC, and MUC6), based on a receiver operating characteristic (ROC) curve and logistic regression analysis...
  45. Li B, Tang H, Zhang A, Dong J. Prognostic Role of Mucin Antigen MUC4 for Cholangiocarcinoma: A Meta-Analysis. PLoS ONE. 2016;11:e0157878 pubmed publisher
    ..Bio-molecular markers have been used to improve tumor staging and prognosis prediction. Mucin antigen MUC4 (MUC4) has been implicated as a marker for poor survival in various tumors...
  46. Bruyère E, Jonckheere N, Frénois F, Mariette C, Van Seuningen I. The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties: Implication for S100A4 protein. Biochem Biophys Res Commun. 2011;413:325-9 pubmed publisher
    b>MUC4 is a membrane-bound mucin known to participate in tumor progression...
  47. Horn A, Chakraborty S, Dey P, Haridas D, Souchek J, Batra S, et al. Immunocytochemistry for MUC4 and MUC16 is a useful adjunct in the diagnosis of pancreatic adenocarcinoma on fine-needle aspiration cytology. Arch Pathol Lab Med. 2013;137:546-51 pubmed publisher
    ..We have identified the expression of 3 genes, MUC4, MUC16, and NGAL that are highly upregulated in pancreatic adenocarcinoma...
  48. Cowan M, Thompson L, Leon M, Bishop J. Low-Grade Fibromyxoid Sarcoma of the Head and Neck: A Clinicopathologic Series and Review of the Literature. Head Neck Pathol. 2016;10:161-6 pubmed publisher
    ..Most LGFMSs harbor a characteristic gene fusion of FUS-CREB3L2, and recently MUC4 immunostaining has been found to be highly sensitive and specific for the diagnosis...
  49. Zhang W, Zhu Y, Zhou D, Wu Q, Song D, Dicksved J, et al. Oral Administration of a Select Mixture of Bacillus Probiotics Affects the Gut Microbiota and Goblet Cell Function following Escherichia coli Challenge in Newly Weaned Pigs of Genotype MUC4 That Are Supposed To Be Enterotoxigenic E. coli F4ab/ac Rece. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..subtilis mixture (BLS mix) were orally administered to piglets of genotype MUC4 that are supposed to be F4-expressing enterotoxigenic Escherichia coli strain (F4+ ETEC) F4ab/ac ..
  50. Vallejo Benítez A, Rodríguez Zarco E, Carrasco S, Pereira Gallardo S, Brugal Molina J, Garcia Escudero A, et al. Expression of dog1 in low-grade fibromyxoid sarcoma: A study of 19 cases and review of the literature. Ann Diagn Pathol. 2017;30:8-11 pubmed publisher
    ..Positive staining for MUC4 was observed in 18/19 cases (94.7%), while there was rearrangement of the FUS gene in 14/19 (73...
  51. Hirabayashi K, Yamada M, Kono H, Hadano A, Kawanishi A, Takanashi Y, et al. Epidermoid cysts are a characteristic feature of intrapancreatic but not of extrapancreatic accessory spleens. Virchows Arch. 2017;471:91-98 pubmed publisher
    ..The superficial/luminal layer was positive for MUC4, CK7, and CA19-9 in all cases (100%), for CEA and HBME-1 in three cases (50%), and for MUC1, CK5/6, and CK20 in two ..
  52. Xie K, Zhi X, Tang J, Zhu Y, Zhang J, Li Z, et al. Upregulation of the splice variant MUC4/Y in the pancreatic cancer cell line MIA PaCa-2 potentiates proliferation and suppresses apoptosis: new insight into the presence of the transcript variant of MUC4. Oncol Rep. 2014;31:2187-94 pubmed publisher
    b>MUC4/Y, the transcript variant 4 of MUC4, lacks exon 2 as compared with the transcript variant 1 of MUC4. To date, direct evidence for the function of MU4/Y remains to be reported...
  53. Macha M, Rachagani S, Pai P, Gupta S, Lydiatt W, Smith R, et al. MUC4 regulates cellular senescence in head and neck squamous cell carcinoma through p16/Rb pathway. Oncogene. 2015;34:1698-708 pubmed publisher
    ..b>MUC4, a high molecular weight glycoprotein, is differentially overexpressed in many human cancers and implicated in ..
  54. Gao L, Liu J, Zhang B, Zhang H, Wang D, Zhang T, et al. Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Tumour Biol. 2014;35:1335-41 pubmed publisher
    The mucin MUC4 is a high molecular weight membrane-bound transmembrane glycoprotein that is frequently detected in invasive and metastatic cancer. The overexpression of MUC4 is associated with increased risks for several types of cancer...
  55. Momi N, Ponnusamy M, Kaur S, Rachagani S, Kunigal S, Chellappan S, et al. Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through ?7nAChR-mediated MUC4 upregulation. Oncogene. 2013;32:1384-95 pubmed publisher
    ..Our previous studies revealed an aberrant expression of the MUC4 mucin in PC as compared with the normal pancreas, and its association with cancer progression and metastasis...
  56. Amatya V, Kushitani K, Mawas A, Miyata Y, Okada M, Kishimoto T, et al. MUC4, a novel immunohistochemical marker identified by gene expression profiling, differentiates pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma. Mod Pathol. 2017;30:672-681 pubmed publisher
    ..sarcomatoid mesothelioma and lung sarcomatoid carcinoma and observed significant differences in the expression of MUC4 and other genes between sarcomatoid mesothelioma and lung sarcomatoid carcinoma...
  57. Creytens D, Ferdinande L, Van Dorpe J. A Sclerosing Perineurioma With Collagen Rosette Formation: Benign Mimic of Low-Grade Fibromyxoid Sarcoma. Int J Surg Pathol. 2017;:1066896917741551 pubmed publisher
    ..resulting in the FUS-CREB3L2, FUS-CREB3L1 or EWSR1-CREB3L1 fusion genes, respectively) or immunoreactivity for MUC4, a recently described sensitive and specific marker for low-grade fibromyxoid sarcoma, remain the gold standard in ..
  58. Yokoyama S, Higashi M, Kitamoto S, Oeldorf M, Knippschild U, Kornmann M, et al. Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomas. Oncotarget. 2016;7:42553-42565 pubmed publisher
    ..Mucins (MUC) play crucial roles in carcinogenesis and tumor invasion in pancreatic neoplasms. MUC1 and MUC4 are high molecular weight transmembrane mucins...
  59. Kumar S, Das S, Rachagani S, Kaur S, Joshi S, Johansson S, et al. NCOA3-mediated upregulation of mucin expression via transcriptional and post-translational changes during the development of pancreatic cancer. Oncogene. 2015;34:4879-89 pubmed publisher
    ..Analysis of chromatin modifying enzymes by PCR array identified differential expression of NCOA3 in MUC4-expressing PC cell lines...
  60. Yang K, He M, Cai Z, Ni C, Deng J, Ta N, et al. A decrease in miR-150 regulates the malignancy of pancreatic cancer by targeting c-Myb and MUC4. Pancreas. 2015;44:370-9 pubmed publisher
    ..The associations of miR-150, c-Myb, and MUC4 expression with survival rates were determined...
  61. Zhu Y, Zhang J, Xie K, Tang J, Liang W, Zhu R, et al. Specific-detection of clinical samples, systematic functional investigations, and transcriptome analysis reveals that splice variant MUC4/Y contributes to the malignant progression of pancreatic cancer by triggering malignancy-related positive feedba. J Transl Med. 2014;12:309 pubmed publisher
    b>MUC4 plays important roles in the malignant progression of human pancreatic cancer. But the huge length of MUC4 gene fragment restricts its functional and mechanism research...
  62. Cho J, Park M, Lee J, Yoon J. Reduced MUC4 expression is a late event in breast carcinogenesis and is correlated with increased infiltration of immune cells as well as promoter hypermethylation in invasive breast carcinoma. Appl Immunohistochem Mol Morphol. 2015;23:44-53 pubmed publisher
    Altered expression of MUC4 is associated with tumor progression and immune surveillance, but the potential involvement of MUC4 in breast carcinogenesis has not been rigorously assessed...
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    ..These mucin genes were up-regulated after exposure to low pH in vitro (p < 0.005). Pepsin inhibited this up-regulation (p <0.001). Reflux laryngitis is associated with down-regulation of mucin gene expression. ..