MUC20

Summary

Gene Symbol: MUC20
Description: mucin 20, cell surface associated
Alias: MUC-20, mucin-20, transmembrane mucin MUC20S
Species: human
Products:     MUC20

Top Publications

  1. Samuels T, Handler E, Syring M, Pajewski N, Blumin J, Kerschner J, et al. Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux. Ann Otol Rhinol Laryngol. 2008;117:688-95 pubmed
    ..These mucin genes were up-regulated after exposure to low pH in vitro (p < 0.005). Pepsin inhibited this up-regulation (p <0.001). Reflux laryngitis is associated with down-regulation of mucin gene expression. ..
  2. Higuchi T, Orita T, Katsuya K, Yamasaki Y, Akiyama K, Li H, et al. MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met. Mol Cell Biol. 2004;24:7456-68 pubmed
    A cDNA encoding a novel mucin protein, MUC20, was isolated as a gene that is up-regulated in the renal tissues of patients with immunoglobulin A nephropathy...
  3. Higuchi T, Orita T, Nakanishi S, Katsuya K, Watanabe H, Yamasaki Y, et al. Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney. J Biol Chem. 2004;279:1968-79 pubmed
    ..residues and likely to be extensively O-glycosylated; thus, this gene was classified in the mucin family and named MUC20. The human MUC20 gene contains at least four exons and is localized close to MUC4 on chromosome 3q29...
  4. Chen C, Wang S, Chen C, Huang M, Hung J, Huang H, et al. MUC20 overexpression predicts poor prognosis and enhances EGF-induced malignant phenotypes via activation of the EGFR-STAT3 pathway in endometrial cancer. Gynecol Oncol. 2013;128:560-7 pubmed publisher
    ..Mucins play a critical role in the malignancy of various tumors and have been identified as diagnostic markers and as attractive therapeutic targets. However, the role of mucin (MUC) 20 in endometrial cancer (EC) is still unknown...
  5. Kasprzak A, Adamek A. Mucins: the Old, the New and the Promising Factors in Hepatobiliary Carcinogenesis. Int J Mol Sci. 2019;20: pubmed publisher
    ..g., MUC2, MUC5AC, MUC6) and soluble (non-gel-forming) (e.g., MUC7, MUC8, MUC9, MUC20), are critical in maintaining cellular functions, particularly those of epithelial surfaces...
  6. Jonckheere N, Van Seuningen I. Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas. J Transl Med. 2018;16:259 pubmed publisher
    ..In addition, we showed that MUC4 expression is correlated with MUC16 and MUC20, two other membrane-bound mucins...
  7. Chen S, Kuo T, Liao Y, Lin M, Tien Y, Huang M. Silencing of MUC20 suppresses the malignant character of pancreatic ductal adenocarcinoma cells through inhibition of the HGF/MET pathway. Oncogene. 2018;37:6041-6053 pubmed publisher
    ..In this study, immunohistochemical staining demonstrated that high MUC20 expression correlated with poor progression-free survival and high local recurrence rate of PDAC patients (n = ..
  8. Pechar R, Rada V, Parafati L, Musilova S, Bunesova V, Vlkova E, et al. Mupirocin-mucin agar for selective enumeration of Bifidobacterium bifidum. Int J Food Microbiol. 2014;191:32-5 pubmed publisher
    ..Isolated strains of B. bifidum were identified using biochemical, PCR, MALDI-TOF procedures and 16S rRNA gene sequencing. The novel selective medium was also suitable for the isolation of B. bifidum strains from human fecal samples. ..
  9. Liu P, Pieper R, Tedin L, Martin L, Meyer W, Rieger J, et al. Effect of dietary zinc oxide on jejunal morphological and immunological characteristics in weaned piglets. J Anim Sci. 2014;92:5009-18 pubmed publisher
    ..Intraepithelial lymphocytes were characterized by flow cytometry and the gene expression of mucin 2 (MUC2), mucin 20 (MUC20), β-defensin 3, and trefoil factor 3 (TFF3) was determined by reverse transcription quantitative PCR...

More Information

Publications25

  1. Erinjeri N, Nicolson N, Deyholos C, Korah R, Carling T. Whole-Exome Sequencing Identifies Two Discrete Druggable Signaling Pathways in Follicular Thyroid Cancer. J Am Coll Surg. 2018;226:950-959.e5 pubmed publisher
    ..Recurrently mutated cancer driver genes included FRG1 (6/6), CDC27, NCOR1, PRSS1 (5/6), AHCTF1, MUC20, PABPC1, and PABPC3 (4/6)...
  2. Cairns M, Gupta A, Naughton J, Kane M, Clyne M, Joshi L. Glycosylation-related gene expression in HT29-MTX-E12 cells upon infection by Helicobacter pylori. World J Gastroenterol. 2017;23:6817-6832 pubmed publisher
    ..Real-time qRT-PCR demonstrated significant downregulation (1.8-fold, P < 0.05) of the mucin MUC20. REG4 was heavily expressed and significantly downregulated (3.1-fold, P < 0.05) upon infection...
  3. Lee J, Lee J, Yun J, Jeong D, Kim J. DUSP28 links regulation of Mucin 5B and Mucin 16 to migration and survival of AsPC-1 human pancreatic cancer cells. Tumour Biol. 2016;37:12193-12202 pubmed
    ..using the Gene Expression Omnibus public microarray database indicated higher DUSP28, MUC1, MUC4, MUC5B, MUC16 and MUC20 messenger RNA (mRNA) levels in pancreatic cancers compared with normal pancreas tissues...
  4. Chen C, Shyu M, Wang S, Chou C, Huang M, Lin T, et al. MUC20 promotes aggressive phenotypes of epithelial ovarian cancer cells via activation of the integrin β1 pathway. Gynecol Oncol. 2016;140:131-7 pubmed publisher
    Mucin (MUC) 20 has recently been implicated to play a role in human carcinogenesis. However, the role of MUC20 in epithelial ovarian cancer (EOC) remains to be elucidated...
  5. Li G, Zhang H, Lu J, Hou P, Zhou Y, Ma X, et al. [Variable number of tandem repeats polymorphism of MUC20 is associated with the progression of IgA nephropathy]. Zhonghua Yi Xue Za Zhi. 2005;85:1333-8 pubmed
    The MUC20 gene is a novel up-regulated gene that was identified in renal tissues of patients with IgA nephropathy (IgAN) by restriction endonucleolytic analysis of differentially expressed sequences...
  6. Yamamoto Furusho J, Ascaño Gutiérrez I, Furuzawa Carballeda J, Fonseca Camarillo G. Differential Expression of MUC12, MUC16, and MUC20 in Patients with Active and Remission Ulcerative Colitis. Mediators Inflamm. 2015;2015:659018 pubmed publisher
    ..The aim of the present study was to determine the expression of MUC12, MUC16, and MUC20 in colonic tissue from patients with UC in regard to their clinical outcomes. Methods...
  7. Xiao X, Wang L, Wei P, Chi Y, Li D, Wang Q, et al. Role of MUC20 overexpression as a predictor of recurrence and poor outcome in colorectal cancer. J Transl Med. 2013;11:151 pubmed publisher
    Colorectal cancer (CRC) remains one of the most common cancers worldwide. We observed that MUC20 was significantly up-regulated in CRC patients with poor prognosis based on the microarray analysis...
  8. Wang H, Shen L, Lin Y, Shi Q, Yang Y, Chen K. The expression and prognostic significance of Mucin 13 and Mucin 20 in esophageal squamous cell carcinoma. J Cancer Res Ther. 2015;11 Suppl 1:C74-9 pubmed publisher
    Mucin 13 (MUC13) and Mucin 20 (MUC20) are high molecular weight transmembrane O-linked glycoprotein secreted by epithelium and are widely overexpressed in epithelial tumor cells...
  9. Shen L, Wang H, Dong B, Yan W, Lin Y, Shi Q, et al. Possible prediction of the response of esophageal squamous cell carcinoma to neoadjuvant chemotherapy based on gene expression profiling. Oncotarget. 2016;7:4531-41 pubmed publisher
    ..IHC was conducted to examine the expression of selected target markers MUC4, MUC13, and MUC20 in 186 ESCC resection samples and the relationships between their expression and tumor regression grade was ..
  10. Cao R, Wang T, DeMaria G, Sheehan J, Kesimer M. Mapping the protein domain structures of the respiratory mucins: a mucin proteome coverage study. J Proteome Res. 2012;11:4013-23 pubmed publisher
    ..Only one peptide was identified from MUC20, which led us to successful antisera raised against the molecule...
  11. Moehle C, Ackermann N, Langmann T, Aslanidis C, Kel A, Kel Margoulis O, et al. Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease. J Mol Med (Berl). 2006;84:1055-66 pubmed
    ..0003) with UC. These data suggest that the disturbed expression of mucin genes and the connection to the NFkappaB pathway may influence the integrity of the intestine and therefore contribute to the pathophysiology of IBD. ..
  12. Li G, Zhang H, Lv J, Hou P, Wang H. Tandem repeats polymorphism of MUC20 is an independent factor for the progression of immunoglobulin A nephropathy. Am J Nephrol. 2006;26:43-9 pubmed
    b>MUC20, an upregulated novel gene in the renal tissues of patients with IgA nephropathy (IgAN), was recently identified. The variable number of tandem repeats (VNTR) polymorphism of the MUC20 gene was detected in several cell lines...
  13. Kesimer M, Ehre C, Burns K, Davis C, Sheehan J, Pickles R. Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways. Mucosal Immunol. 2013;6:379-92 pubmed publisher
    ..Immuno-histology by light and electron microscopy localized MUC1 to microvilli, MUC4 and MUC20 to cilia, and MUC16 to goblet cells...
  14. Woodward A, Argüeso P. Expression analysis of the transmembrane mucin MUC20 in human corneal and conjunctival epithelia. Invest Ophthalmol Vis Sci. 2014;55:6132-8 pubmed publisher
    ..The aim of this study was to investigate the localization and regulation of mucin 20 (MUC20) at the ocular surface...
  15. Horn T, Grab J, Schusdziarra J, Schmid S, Maurer T, Nawroth R, et al. Antitumor T cell responses in bladder cancer are directed against a limited set of antigens and are modulated by regulatory T cells and routine treatment approaches. Int J Cancer. 2013;133:2145-56 pubmed publisher
    ..After depleting Treg, also new york esophageal (NYES)O1 (19 and 0%) and MUC20 (27 and 0%) were more frequently recognized in UC patients...
  16. Ma J, Rubin B, Voynow J. Mucins, Mucus, and Goblet Cells. Chest. 2018;154:169-176 pubmed publisher
    ..MUC5AC, MUC5B), and those that have transmembrane domains and are cell surface associated (MUC1, MUC4, MUC16, MUC20)...