MUC2

Summary

Gene Symbol: MUC2
Description: mucin 2, oligomeric mucus/gel-forming
Alias: MLP, MUC-2, SMUC, mucin-2, mucin 2, intestinal/tracheal
Species: human
Products:     MUC2

Top Publications

  1. Kim Y, Kwon E, Park D, Song S, Yoon S, Baek S. Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells. Mol Pharmacol. 2002;62:1112-8 pubmed
    ..In this study, we investigated the regulation of MUC2 and MUC5AC expression and of their regulatory mechanisms through cyclooxygenase-2 (COX-2) and prostaglandin E(2) (..
  2. Kim Y, Jeon J, Woo H, Lee J, Chung J, Song S, et al. Interleukin-1beta induces MUC2 gene expression and mucin secretion via activation of PKC-MEK/ERK, and PI3K in human airway epithelial cells. J Korean Med Sci. 2002;17:765-71 pubmed
    Interleukin 1beta(IL-1beta), a proinflammatory cytokine, is related with inflammatory diseases and it up-regulates MUC2 gene expression and mucin secretion...
  3. Mesquita P, Peixoto A, Seruca R, Hanski C, Almeida R, Silva F, et al. Role of site-specific promoter hypomethylation in aberrant MUC2 mucin expression in mucinous gastric carcinomas. Cancer Lett. 2003;189:129-36 pubmed
    ..mucosa and mucinous gastric carcinoma in order to access if the observed de novo expression of the intestinal mucin MUC2 in mucinous gastric carcinoma is associated with changes in MUC2 promoter methylation status...
  4. Lidell M, Johansson M, Hansson G. An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway. J Biol Chem. 2003;278:13944-51 pubmed
    During purification of a recombinant MUC2 C terminus expressed in CHO-K1 cells, the protein was partly cleaved when buffers with a pH of 6.0 were used. When buffers with higher pH values were used, less cleavage was found...
  5. Ishikawa A, Sasaki M, Ohira S, Ohta T, Oda K, Nimura Y, et al. Aberrant expression of CDX2 is closely related to the intestinal metaplasia and MUC2 expression in intraductal papillary neoplasm of the liver in hepatolithiasis. Lab Invest. 2004;84:629-38 pubmed
    ..papillary neoplasia of the liver (IPNL) frequently presents gastrointestinal metaplasia with aberrant expression of MUC2 and MUC5AC and oversecretion of mucin into the ductal lumen...
  6. Kasashima S, Kawashima A, Zen Y, Ozaki S, Kobayashi M, Tsujibata A, et al. Expression of aberrant mucins in lobular carcinoma with histiocytoid feature of the breast. Virchows Arch. 2007;450:397-403 pubmed
    ..profiles were significantly different between the two groups: a fair number of HLC cases were immunopositive for MUC2 and MUC5AC (75 and 50%, respectively); in contrast, almost all CLC cases showed both as negative...
  7. Okudaira K, Kakar S, Cun L, Choi E, Wu Decamillis R, Miura S, et al. MUC2 gene promoter methylation in mucinous and non-mucinous colorectal cancer tissues. Int J Oncol. 2010;36:765-75 pubmed
    Abundant mucin production and MUC2 expression is the key feature of mucinous colorectal cancer (CRC)...
  8. Pigny P, Guyonnet Duperat V, Hill A, Pratt W, Galiegue Zouitina S, d Hooge M, et al. Human mucin genes assigned to 11p15.5: identification and organization of a cluster of genes. Genomics. 1996;38:340-52 pubmed
    Four distinct genes that encode mucins have previously been mapped to chromosome 11p15.5. Three of these genes (MUC2, MUC5AC, and MUC6) show a high level of genetically determined polymorphism and were analyzed in the CEPH families...
  9. Asker N, Axelsson M, Olofsson S, Hansson G. Dimerization of the human MUC2 mucin in the endoplasmic reticulum is followed by a N-glycosylation-dependent transfer of the mono- and dimers to the Golgi apparatus. J Biol Chem. 1998;273:18857-63 pubmed
    ..subcellular fractionation by sucrose density gradient centrifugation showed that the initial dimerization of the MUC2 apomucin started directly after translocation of the apomucin into the rough endoplasmic reticulum as detected by ..

More Information

Publications105 found, 100 shown here

  1. Vinall L, Fowler J, Jones A, Kirkbride H, de Bolos C, Laine A, et al. Polymorphism of human mucin genes in chest disease: possible significance of MUC2. Am J Respir Cell Mol Biol. 2000;23:678-86 pubmed
    ..There was no significant difference in the distribution of alleles of MUC1, MUC4, MUC5AC, and MUC5B. MUC2, however, showed a highly significant difference in distribution...
  2. Iwashita J, Sato Y, Sugaya H, Takahashi N, Sasaki H, Abe T. mRNA of MUC2 is stimulated by IL-4, IL-13 or TNF-alpha through a mitogen-activated protein kinase pathway in human colon cancer cells. Immunol Cell Biol. 2003;81:275-82 pubmed
    b>MUC2 mucin is a secretory glycoprotein which is produced from the intestinal goblet cells and is a major component of the intestinal epithelial mucus...
  3. Byrd J, Bresalier R. Mucins and mucin binding proteins in colorectal cancer. Cancer Metastasis Rev. 2004;23:77-99 pubmed
    ..There are two structurally and functionally distinct classes of mucins: secreted gel-forming mucins (MUC2, MUC5AC, MUC5B, and MUC6) and transmembrane mucins (MUC1, MUC3A, MUC3B, MUC4, MUC12, MUC17), although the products ..
  4. Rousseau K, Byrne C, Kim Y, Gum J, Swallow D, Toribara N. The complete genomic organization of the human MUC6 and MUC2 mucin genes. Genomics. 2004;83:936-9 pubmed
    The complete genomic organization of the two mucin genes MUC2 and MUC6 was obtained by comparison of new and published mRNA sequences with newly available human genomic sequence. The two genes are located 38...
  5. Lee S, Choi D, Jang K, Lee K, Choi S, Heo J, et al. High expression of intestinal-type mucin (MUC2) in intraductal papillary mucinous neoplasms coexisting with extrapancreatic gastrointestinal cancers. Pancreas. 2006;32:186-9 pubmed
    ..The immunohistochemical staining (p21, Bcl-2, p53, intestinal-type secretory mucin [MUC2], and MUC5AC) and the pathological subtypes of the tumor papillae (the intestinal type, pancreaticobiliary type, ..
  6. Lidell M, Moncada D, Chadee K, Hansson G. Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel. Proc Natl Acad Sci U S A. 2006;103:9298-303 pubmed
    ..The MUC2 mucin is the major structural component of the colonic mucus gel...
  7. Vincent A, Perrais M, Desseyn J, Aubert J, Pigny P, Van Seuningen I. Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells. Oncogene. 2007;26:6566-76 pubmed
    The human genes MUC2, MUC5AC, MUC5B and MUC6 are clustered on chromosome 11 and encode large secreted gel-forming mucins...
  8. Jankovic Velickovic L, Katic V, Hattori T, Kushima R, Marjanovic G, Stefanovic V. Differences in the expression of mucins in various forms of cystitis glandularis. Pathol Res Pract. 2007;203:653-8 pubmed
    ..For this examination, we used a panel of monoclonal-specific antibodies for MUC1, MUC2, MUC5AC, and MUC6...
  9. Ambort D, Johansson M, Gustafsson J, Nilsson H, Ermund A, Johansson B, et al. Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin. Proc Natl Acad Sci U S A. 2012;109:5645-50 pubmed publisher
    b>MUC2, the major colonic mucin, forms large polymers by N-terminal trimerization and C-terminal dimerization...
  10. Gum J, Byrd J, Hicks J, Toribara N, Lamport D, Kim Y. Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism. J Biol Chem. 1989;264:6480-7 pubmed
    ..Three cDNAs were isolated from this screening, designated SMUC 40-42...
  11. Gum J, Hicks J, Toribara N, Siddiki B, Kim Y. Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor. J Biol Chem. 1994;269:2440-6 pubmed
    ..In this paper, we identify and sequence cDNAs that encode the amino terminus of the MUC2 protein, a major form of mucin found in human intestines and airways...
  12. Herrmann A, Davies J, Lindell G, Mårtensson S, Packer N, Swallow D, et al. Studies on the "insoluble" glycoprotein complex from human colon. Identification of reduction-insensitive MUC2 oligomers and C-terminal cleavage. J Biol Chem. 1999;274:15828-36 pubmed
    ..Antibodies raised against peptide sequences within MUC2 revealed that virtually all of this mucin occurs in the insoluble glycoprotein complex...
  13. Yamamoto H, Bai Y, Yuasa Y. Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression. Biochem Biophys Res Commun. 2003;300:813-8 pubmed
    Intestinal mucin gene MUC2 is abundantly expressed in goblet cells...
  14. Sternberg L, Byrd J, Hansson G, Liu K, Bresalier R. Alternative splicing of the human MUC2 gene. Arch Biochem Biophys. 2004;421:21-33 pubmed
    Human colon cancers differ in amounts of MUC2 mucin synthesized. However, it is unclear whether MUC2 encodes a single protein...
  15. Ahn D, Crawley S, Hokari R, Kato S, Yang S, Li J, et al. TNF-alpha activates MUC2 transcription via NF-kappaB but inhibits via JNK activation. Cell Physiol Biochem. 2005;15:29-40 pubmed
    The molecular mechanisms responsible for TNF-alpha-mediated MUC2 intestinal mucin up-regulation in HM3 colon adenocarcinoma cells were analyzed using promoter-reporter assays of the 5'-flanking region of the MUC2 gene...
  16. Yamada N, Hamada T, Goto M, Tsutsumida H, Higashi M, Nomoto M, et al. MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. Int J Cancer. 2006;119:1850-7 pubmed
    Mucins are highly glycosylated proteins that play important roles in carcinogenesis. In pancreatic neoplasia, MUC2 mucin has been demonstrated as a tumor suppressor and we have reported that MUC2 is a favorable prognostic factor...
  17. Li Y, Hsieh L, Tang R, Liao S, Yeh K. Macrophage-derived interleukin-6 up-regulates MUC1, but down-regulates MUC2 expression in the human colon cancer HT-29 cell line. Cell Immunol. 2009;256:19-26 pubmed publisher
    ..and intracellular staining methods, we found that macrophage supernatant effectively induced MUC1 up-regulation and MUC2 down-regulation of colon cancer cells in vitro...
  18. Subramani D, Johansson M, Dahlen G, Hansson G. Lactobacillus and Bifidobacterium species do not secrete protease that cleaves the MUC2 mucin which organises the colon mucus. Benef Microbes. 2010;1:343-50 pubmed publisher
    The colon epithelium is covered by two layers of mucus built around the MUC2 mucin. An inner dense and attached mucus layer does not allow bacteria to penetrate, thus keeping the epithelial cell surface free from bacteria...
  19. Mazzio E, Soliman K. Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A. Cancer Genomics Proteomics. 2018;15:349-364 pubmed publisher
    ..TSA does not alter HDAC transcripts nor BRAF itself, but down-regulates critical components of the MAPK/MEK/BRAF oncogenic pathway, initiating a mitotic arrest. ..
  20. Darnaud M, Dos Santos A, Gonzalez P, Augui S, Lacoste C, Desterke C, et al. Enteric Delivery of Regenerating Family Member 3 alpha Alters the Intestinal Microbiota and Controls Inflammation in Mice With Colitis. Gastroenterology. 2018;154:1009-1023.e14 pubmed publisher
    ..Colon tissues were collected from mice and analyzed by histology and immunohistochemistry to detect mucin 2, as well as by 16S ribosomal RNA fluorescence in situ hybridization, transcriptional analyses, and quantitative ..
  21. Laudisi F, Di Fusco D, Dinallo V, Stolfi C, Di Grazia A, Marafini I, et al. The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress-Driven Mucus Depletion and Exacerbates Intestinal Inflammation. Cell Mol Gastroenterol Hepatol. 2018;7:457-473 pubmed publisher
    ..MDX increases ER stress in gut epithelial cells with the downstream effect of reducing mucus production and enhancing colitis susceptibility. ..
  22. Pujar M, Vastrad B, Vastrad C. Integrative Analyses of Genes Associated with Subcutaneous Insulin Resistance. Biomolecules. 2019;9: pubmed publisher
    ..The current study based on the GEO database provides a novel understanding regarding the mechanism of insulin resistance and may provide novel therapeutic targets. ..
  23. Klepsch V, Gerner R, Klepsch S, Olson W, Tilg H, Moschen A, et al. Nuclear orphan receptor NR2F6 as a safeguard against experimental murine colitis. Gut. 2018;67:1434-1444 pubmed publisher
    ..tissue destruction and immune cell infiltration together with enhanced intestinal permeability and reduced Muc2 expression...
  24. Cheng R, Yao J, Wan Q, Guo J, Pu F, Shi L, et al. Oral administration of Bifidobacterium bifidum TMC3115 to neonatal mice may alleviate IgE-mediated allergic risk in adulthood. Benef Microbes. 2018;9:815-828 pubmed publisher
    ..systemic inflammation or other clinical symptoms among the neonatal or adult mice, although the crypt depths and Muc2-positive cells in some intestinal segments of neonatal mice were significantly lower than control...
  25. Amer M, Nadeem M, Nazir S, Fakhar M, Abid F, Ain Q, et al. Probiotics and Their Use in Inflammatory Bowel Disease. Altern Ther Health Med. 2017;: pubmed
    ..acids; (2) decreased production of tumor necrosis factor alpha and interleukin 8; (3) increased expression of mucin 2; and (4) increased upregulation of defensin...
  26. Pérez Bosque A, Miró L, Maijó M, Polo J, Campbell J, Russell L, et al. Dietary intervention with serum-derived bovine immunoglobulins protects barrier function in a mouse model of colitis. Am J Physiol Gastrointest Liver Physiol. 2015;308:G1012-8 pubmed
    ..Mucins (MUC1, MUC2, MUC4), TFF3, cytokines (TNF-α, IFN-γ), and inducible nitric oxide synthase RNA expression were quantified by ..
  27. Kawahara T, Makizaki Y, Oikawa Y, Tanaka Y, Maeda A, Shimakawa M, et al. Oral administration of Bifidobacterium bifidum G9-1 alleviates rotavirus gastroenteritis through regulation of intestinal homeostasis by inducing mucosal protective factors. PLoS ONE. 2017;12:e0173979 pubmed publisher
    ..the number of acidic mucin-positive goblet cells and the gene expression of mucosal protective factors including MUC2, MUC3, MUC4, TGF?1 and TFF3 in the small intestine...
  28. Yokoyama S, Kitamoto S, Higashi M, Goto Y, Hara T, Ikebe D, et al. Diagnosis of pancreatic neoplasms using a novel method of DNA methylation analysis of mucin expression in pancreatic juice. PLoS ONE. 2014;9:e93760 pubmed publisher
    ..have shown a consensus position on mucin expression profiles in pancreatic neoplasms as follows: MUC1-positive but MUC2-negative expression in PDACs; MUC1-negative but MUC2-positive expression in intestinal-type IPMNs (dangerous type); ..
  29. Nilsson H, Ambort D, Bäckström M, Thomsson E, Koeck P, Hansson G, et al. Intestinal MUC2 mucin supramolecular topology by packing and release resting on D3 domain assembly. J Mol Biol. 2014;426:2567-2579 pubmed publisher
    b>MUC2 is the major gel-forming mucin of the colon forming a protective gel barrier organized into an inner stratified and an outer loose layer...
  30. Wolf K, Strand S. Assessing the Histone Deacetylase Activity of SIRT6 in Primary Murine Hepatocytes via Proximity Ligation Assay. Methods Mol Biol. 2017;1510:149-158 pubmed
    Generation of primary cell culture of hepatocytes by mouse liver perfusion (MLP) combines the advantages of in vivo and in vitro models...
  31. Yi H, Hu W, Chen S, Lu Z, Wang Y. Cathelicidin-WA Improves Intestinal Epithelial Barrier Function and Enhances Host Defense against Enterohemorrhagic Escherichia coli O157:H7 Infection. J Immunol. 2017;198:1696-1705 pubmed publisher
    ..In conclusion, CWA attenuated EHEC-induced inflammation, intestinal epithelial barrier damage, and microbiota disruption in the intestine of mice, suggesting that CWA may be an effective therapy for many intestinal diseases. ..
  32. Huang H, Chen A. [Expression of mucin regulated by recombinant human interleukin-6 in HT-29 cell of colon cancer]. Zhonghua Wei Chang Wai Ke Za Zhi. 2011;14:899-902 pubmed
    ..5)%, respectively, higher than (8.0±0.8)% in the negative controls (P<0.01), meanwhile, the expression of mucin 2 decreased by rIL-6 with concentration above 2 ?g/L, the expression rates were(30.5±2.6)%, (17.0±2.7)%, (11.0±2...
  33. Benoit B, Bruno J, Kayal F, Estienne M, Debard C, Ducroc R, et al. Saturated and Unsaturated Fatty Acids Differently Modulate Colonic Goblet Cells In Vitro and in Rat Pups. J Nutr. 2015;145:1754-62 pubmed publisher
    ..Little is known about the effects of long-chain fatty acids (LCFAs) on mucin 2 (MUC2) production by goblet cells, which are crucial for intestinal protection...
  34. Arike L, Hansson G. The Densely O-Glycosylated MUC2 Mucin Protects the Intestine and Provides Food for the Commensal Bacteria. J Mol Biol. 2016;428:3221-3229 pubmed publisher
    ..This makes the intestinal main mucin MUC2 non-degradable by the host digestive system but well by both commensal and pathogenic bacteria...
  35. Hopkins D. Destabilising automobility? The emergent mobilities of generation Y. Ambio. 2017;46:371-383 pubmed publisher
    ..the actor-centred Energy Cultures Framework to explore mobility behaviours, and the multi-level perspective (MLP) to situate behaviour change within the socio-technical transitions literature...
  36. Shi L, Iguchi M. "Risk homeostasis"or "teachable moment"? the interaction between smoking behavior and lung cancer screening in the Mayo Lung Project. Tob Induc Dis. 2011;9:2 pubmed publisher
    The chest X-ray lung cancer screening program of Mayo Lung Project (MLP) yielded mixed results of improved lung case survival but no improvement in lung cancer mortality...
  37. Sriraam N, Padma Shri T, Maheshwari U. Recognition of wake-sleep stage 1 multichannel eeg patterns using spectral entropy features for drowsiness detection. Australas Phys Eng Sci Med. 2016;39:797-806 pubmed publisher
    ..sleep EEG data are estimated for each second and applied to a multilayer perceptron feed forward neural network (MLP-FF). The network is trained using back propagation algorithm for recognizing these two patterns...
  38. Wang Q, Zhou Y, Rychahou P, Fan T, Lane A, Weiss H, et al. Ketogenesis contributes to intestinal cell differentiation. Cell Death Differ. 2017;24:458-468 pubmed publisher
    ..induces intestinal cell differentiation as noted by the increased expression of differentiation markers (Mucin2 (MUC2), lysozyme, IAP, sucrase-isomaltase, KRT20, villin, Caudal-related homeobox transcription factor 2 (CDX2) and p21<..
  39. Correll R, Lynch J, Schips T, Prasad V, York A, Sargent M, et al. Mitsugumin 29 regulates t-tubule architecture in the failing heart. Sci Rep. 2017;7:5328 pubmed publisher
    ..Interestingly, expression of Mg29 in the hearts of Csrp3 null mice (encoding muscle LIM protein, MLP) partially restored t-tubule structure and preserved cardiac function as measured by invasive hemodynamics, without ..
  40. Sveen L, Grammes F, Ytteborg E, Takle H, Jørgensen S. Genome-wide analysis of Atlantic salmon (Salmo salar) mucin genes and their role as biomarkers. PLoS ONE. 2017;12:e0189103 pubmed publisher
    ..Two genes were annotated as muc2 and five genes as muc5...
  41. Huang X, Li Y, Wang T, Li P, Liu X, Liu H, et al. [Interleukin-1beta induces MUC2/MUC5B gene expression in human nasal epithelial cells]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010;24:632-5 pubmed
    To demonstrate the effects of IL-1beta on MUC2/MUC5B gene expression in cultured human nasal epithelial cells...
  42. Elzagheid A, Emaetig F, Buhmeida A, Laato M, El Faitori O, Syrjanen K, et al. Loss of MUC2 expression predicts disease recurrence and poor outcome in colorectal carcinoma. Tumour Biol. 2013;34:621-8 pubmed publisher
    ..IV CRC treated during 1981-1990 at Turku University Hospital (Finland) were used (as microarray blocks) to analyze MUC2 expression by immunohistochemistry. Altogether, 49.7 % of all tumors were positive for MUC2...
  43. Qu C, Yuan Z, Yu X, Huang Y, Yang G, Chen J, et al. Patchouli alcohol ameliorates dextran sodium sulfate-induced experimental colitis and suppresses tryptophan catabolism. Pharmacol Res. 2017;121:70-82 pubmed publisher
    ..The results provided valuable information and guidance for using PA in treatment of UC. ..
  44. Znalesniak E, Fu T, Salm F, Händel U, Hoffmann W. Transcriptional Responses in the Murine Spleen after Toxoplasma gondii Infection: Inflammasome and Mucus-Associated Genes. Int J Mol Sci. 2017;18: pubmed publisher
    ..e., gastrokines (Gkn), IgG Fc binding protein (Fcgbp), and the mucin Muc2. The corresponding gene products belong to an interactome protecting mucous epithelia...
  45. Onwude D, Hashim N, Abdan K, Janius R, Chen G. The potential of computer vision, optical backscattering parameters and artificial neural network modelling in monitoring the shrinkage of sweet potato (Ipomoea batatas L.) during drying. J Sci Food Agric. 2018;98:1310-1324 pubmed publisher
    ..A multilayer perceptron (MLP) artificial neural network with input layer containing three cells, two hidden layers (18 neurons), and five cells ..
  46. Shimobaba T, Kuwata N, Homma M, Takahashi T, Nagahama Y, Sano M, et al. Convolutional neural network-based data page classification for holographic memory. Appl Opt. 2017;56:7327-7330 pubmed publisher
    ..We numerically investigated the classification performance of a conventional multilayer perceptron (MLP) and a deep neural network, under the condition that reconstructed page data are contaminated by some noise and are ..
  47. Jany B, Gallup M, Yan P, Gum J, Kim Y, Basbaum C. Human bronchus and intestine express the same mucin gene. J Clin Invest. 1991;87:77-82 pubmed
    ..By screening a bronchus cDNA library with an intestinal mucin cDNA, SMUC-41, we isolated a bronchus mucin cDNA, HAM-1. This cDNA is 96% homologous to the first repeat of SMUC-41...
  48. Samuels T, Handler E, Syring M, Pajewski N, Blumin J, Kerschner J, et al. Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux. Ann Otol Rhinol Laryngol. 2008;117:688-95 pubmed
    ..These mucin genes were up-regulated after exposure to low pH in vitro (p < 0.005). Pepsin inhibited this up-regulation (p <0.001). Reflux laryngitis is associated with down-regulation of mucin gene expression. ..
  49. Karamanlı H, Yalcinoz T, Yalcinoz M, Yalcinoz T. A prediction model based on artificial neural networks for the diagnosis of obstructive sleep apnea. Sleep Breath. 2016;20:509-14 pubmed publisher
    ..ANN classifiers were assessed with the multilayer perceptron (MLP) networks. Use of the MLP classifiers resulted in a diagnostic accuracy of 86...
  50. Rahman A, Robinson A, Jovanovska V, Eri R, Nurgali K. Alterations in the distal colon innervation in Winnie mouse model of spontaneous chronic colitis. Cell Tissue Res. 2015;362:497-512 pubmed publisher
    ..The recently established Winnie mouse model of spontaneous chronic colitis caused by a point mutation in the Muc2 mucin gene develops inflammation due to a primary epithelial defect...
  51. Renaud F, Mariette C, Vincent A, Wacrenier A, Maunoury V, Leclerc J, et al. The serrated neoplasia pathway of colorectal tumors: Identification of MUC5AC hypomethylation as an early marker of polyps with malignant potential. Int J Cancer. 2016;138:1472-81 pubmed publisher
    ..and molecular analysis of a large series of colorectal serrated polyps and evaluated the usefulness of mucin genes MUC2 and MUC5AC to differentiate serrated polyps and to identify lesions with malignant potential...
  52. Shen C, Zhang H, Wang P, Feng J, Li J, Xu Y, et al. Deoxycholic acid (DCA) confers an intestinal phenotype on esophageal squamous epithelium via induction of the stemness-associated reprogramming factors OCT4 and SOX2. Cell Cycle. 2016;15:1439-49 pubmed publisher
    ..cell-reprogramming factors, in the deoxycholic acid (DCA)-induced expression of the intestinal hallmarks Cdx2 and MUC2 using both in vivo and in vitro models...
  53. Isler Y. Discrimination of systolic and diastolic dysfunctions using multi-layer perceptron in heart rate variability analysis. Comput Biol Med. 2016;76:113-9 pubmed publisher
    ..The nearest neighbor and the multi-layer perceptron (MLP) are used to evaluate the performances in discriminating these two groups...
  54. Hirato M, Miyagishima T, Takahashi A, Yoshimoto Y. Superselective Thalamotomy in the Most Lateral Part of the Ventralis Intermedius Nucleus for Controlling Essential and Parkinsonian Tremor. World Neurosurg. 2018;109:e630-e641 pubmed publisher
    ..in cases treated by superselective thalamotomy in the most lateral part of the ventralis intermedius nucleus (mlp-VIM)...
  55. Bajka B, Rigby N, Cross K, Macierzanka A, Mackie A. The influence of small intestinal mucus structure on particle transport ex vivo. Colloids Surf B Biointerfaces. 2015;135:73-80 pubmed publisher
    ..The porcine jejunum and ileum were filled with mucus. Layered MUC2 staining was visible throughout the small intestine, covering villus tips...
  56. Amini A, Masoumi Moghaddam S, Ehteda A, Liauw W, Morris D. Depletion of mucin in mucin-producing human gastrointestinal carcinoma: Results from in vitro and in vivo studies with bromelain and N-acetylcysteine. Oncotarget. 2015;6:33329-44 pubmed publisher
    ..Similarly, mucinous differentiation of gastrointestinal tumors, in particular increased or de novo expression of MUC2 and/or MUC5AC, is widely believed to imply an adverse clinicopathological feature...
  57. Noya V, Brossard N, Berasaín P, Rodríguez E, Chiale C, Mazal D, et al. A mucin-like peptide from Fasciola hepatica induces parasite-specific Th1-type cell immunity. Parasitol Res. 2016;115:1053-63 pubmed publisher
    ..These results suggest that the mucin-like peptide Fhmuc could constitute a potential vaccine candidate against fasciolosis and pave the way towards the development of vaccines against parasites. ..
  58. Dalla Bella S, Farrugia N, Benoit C, Bégel V, Verga L, Harding E, et al. BAASTA: Battery for the Assessment of Auditory Sensorimotor and Timing Abilities. Behav Res Methods. 2017;49:1128-1145 pubmed publisher
    ..thresholds for duration discrimination and anisochrony detection are estimated with a maximum likelihood procedure (MLP) algorithm...
  59. Ohashi R, Hayama A, Yanagihara K, Yamashita K, Sakatani T, Takei H, et al. Prognostic significance of mucin expression profiles in breast carcinoma with signet ring cells: a clinicopathological study. Diagn Pathol. 2016;11:131 pubmed
    ..characteristics of patients with breast cancer containing SRCs in relation to the expression levels of MUC1, MUC2, MUC4, MUC5AC, and MUC6...
  60. Ermund A, Meiss L, Gustafsson J, Hansson G. Hyper-osmolarity and calcium chelation: Effects on cystic fibrosis mucus. Eur J Pharmacol. 2015;764:109-17 pubmed publisher
    ..We have recently shown that bicarbonate ions passing through CFTR are necessary for proper unfolding of the MUC2 mucin, thus highlighting the importance of bicarbonate ion transport via the CFTR and the ability of these ions to ..
  61. Gulhane M, Murray L, Lourie R, Tong H, Sheng Y, Wang R, et al. High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22. Sci Rep. 2016;6:28990 pubmed publisher
    ..signature, alongside compromised mucosal barrier integrity with a decrease in goblet cell differentiation and Muc2, a loss in the tight junction protein, claudin-1 and increased serum endotoxin levels...
  62. Zoghbi S, Drouin E, Claustre J, Bara J, Scoazec J, Plaisancie P. Intestinal MUC2 and gastric M1/MUC5AC in preneoplastic lesions induced by 1,2-dimethylhydrazine in rat: a sequential analysis. Int J Oncol. 2007;30:489-97 pubmed
    Our study was performed to sequentially analyze the expression of the intestinal mucin MUC2 and of the gastric mucin MUC5AC as indicators during progression of preneoplastic biomarkers in rat colon...
  63. Prakash R, Bharathi Raja S, Devaraj H, Devaraj S. Up-regulation of MUC2 and IL-1? expression in human colonic epithelial cells by Shigella and its interaction with mucins. PLoS ONE. 2011;6:e27046 pubmed publisher
    ..The entire gastrointestinal tract is protected by a mucous layer, which contains complex glycoproteins called mucins. MUC2 is one such mucin that protects the colonic mucosa from invading microbes...
  64. Chik J, Zhou J, Moh E, Christopherson R, Clarke S, Molloy M, et al. Comprehensive glycomics comparison between colon cancer cell cultures and tumours: implications for biomarker studies. J Proteomics. 2014;108:146-62 pubmed publisher
    ..The expression of a subset of mucins (MUC2, MUC6, MUC5B) was also correlated with sialyl-Tn expression in LS174T cells...
  65. van der Post S, Thomsson K, Hansson G. Multiple enzyme approach for the characterization of glycan modifications on the C-terminus of the intestinal MUC2mucin. J Proteome Res. 2014;13:6013-23 pubmed publisher
    The polymeric mucin MUC2 constitutes the main structural component of the mucus that covers the colon epithelium...
  66. You H, Ma Z, Tang Y, Wang Y, Yan J, Ni M, et al. Comparison of ANN (MLP), ANFIS, SVM, and RF models for the online classification of heating value of burning municipal solid waste in circulating fluidized bed incinerators. Waste Manag. 2017;68:186-197 pubmed publisher
    ..A model with sufficient accuracy would contribute adequately to the control of circulating fluidized bed incinerator operation and provide reliable heating value signals for an automatic combustion control system. ..
  67. Basturk O, Berger M, Yamaguchi H, Adsay V, Askan G, Bhanot U, et al. Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductal papillary mucinous neoplasm and ductal adenocarcinoma. Mod Pathol. 2017;30:1760-1772 pubmed publisher
    ..and no obvious intracellular mucin) and immunohistochemical (immunolabeled with MUC1 and MUC6 but were negative for MUC2 and MUC5AC) features. By genomic analyses, there was loss of CDKN2A in 5/20 (25%) of these cases...
  68. Dellacasa Bellingegni A, Gruppioni E, Colazzo G, Davalli A, Sacchetti R, Guglielmelli E, et al. NLR, MLP, SVM, and LDA: a comparative analysis on EMG data from people with trans-radial amputation. J Neuroeng Rehabil. 2017;14:82 pubmed publisher
    ..05. The comparative analysis among NLR, MLP and SVM shows that, for either classification performance and for the number of classification parameters, SVM ..
  69. Li Y, Chu X, Liu C, Huang W, Yao Y, Xia Y, et al. Exogenous murine antimicrobial peptide CRAMP significantly exacerbates Ovalbumin-induced airway inflammation but ameliorates oxazolone-induced intestinal colitis in BALB/c mice. Hum Vaccin Immunother. 2017;: pubmed publisher
    ..neutrophils recruitment were significantly decreased in CRAMP-treated mice, and epithelial repair-related factors MUC2 and Claudin1 were increased, determined by real time-PCR and ELISAs...
  70. Amari S, Ozeki T, Karakida R, Yoshida Y, Okada M. Dynamics of Learning in MLP: Natural Gradient and Singularity Revisited. Neural Comput. 2018;30:1-33 pubmed publisher
    ..learning play a main role in deep learning, which takes place in the parameter space of a multilayer perceptron (MLP)...
  71. Shangguan X, Zhang J, Liu B, Zhao Y, Wang H, Wang Z, et al. A Mucin-Like Protein of Planthopper Is Required for Feeding and Induces Immunity Response in Plants. Plant Physiol. 2018;176:552-565 pubmed publisher
    ..Our finding that the protein functions in plant immune responses offers new insights into the mechanism underlying interactions between plants and herbivorous insects. ..
  72. Johansson B, Fjeld K, El Jellas K, Gravdal A, Dalva M, Tjora E, et al. The role of the carboxyl ester lipase (CEL) gene in pancreatic disease. Pancreatology. 2018;18:12-19 pubmed publisher
    ..Genome-wide association studies or deep sequencing cannot easily pick up this wealth of genetic variation. CEL is therefore an attractive candidate gene for further exploration of links to pancreatic disease. ..
  73. Griffiths B, Matthews D, West L, Attwood J, Povey S, Swallow D, et al. Assignment of the polymorphic intestinal mucin gene (MUC2) to chromosome 11p15. Ann Hum Genet. 1990;54:277-85 pubmed
    ..1989). We describe here the use of this cDNA to map the gene (MUC2) to human chromosome 11 using somatic cell hybrids, and to make the regional localization to 11p15 by in situ ..
  74. Eckhardt A, Timpte C, DeLuca A, Hill R. The complete cDNA sequence and structural polymorphism of the polypeptide chain of porcine submaxillary mucin. J Biol Chem. 1997;272:33204-10 pubmed
    ..Fragment length polymorphism was also seen within two different families of animals, indicating that the polymorphism observed occurs in a single generation. ..
  75. Schaart M, De Bruijn A, Schierbeek H, Tibboel D, Renes I, van Goudoever J. Small intestinal MUC2 synthesis in human preterm infants. Am J Physiol Gastrointest Liver Physiol. 2009;296:G1085-90 pubmed publisher
    b>Mucin 2 (MUC2) is the structural component of the intestinal protective mucus layer, which contains high amounts of threonine in its peptide backbone. MUC2 synthesis rate might be a potential parameter for intestinal barrier function...
  76. Johansson M, Thomsson K, Hansson G. Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. J Proteome Res. 2009;8:3549-57 pubmed publisher
    ..A major protein was the Muc2 mucin that by its net-like disulfide-bonded polymer structure builds the mucus...
  77. Larsson J, Karlsson H, Crespo J, Johansson M, Eklund L, Sjovall H, et al. Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation. Inflamm Bowel Dis. 2011;17:2299-307 pubmed publisher
    The MUC2 mucin organizes the two mucus layers in the colon. This mucin carries a large number of O-glycans that are assumed to be attachment sites for the commensal flora found in the outer mucus layer...
  78. Chang C, Chen Y, Lin W, Chen C, Chen C, Lee S, et al. MUC2 polymorphisms are associated with endometriosis development and infertility: a case-control study. BMC Med Genet. 2012;13:15 pubmed publisher
    ..This study investigates genetic association of mucin2 (MUC2) with the risk of endometriosis and endometriosis-related infertility...
  79. He Y, Zhang M, Wu X, Sun X, Xu T, He Q, et al. High MUC2 expression in ovarian cancer is inversely associated with the M1/M2 ratio of tumor-associated macrophages and patient survival time. PLoS ONE. 2013;8:e79769 pubmed publisher
    b>Mucin 2 (MUC2) is a mucin molecule aberrantly expressed by ovarian cancer cells. Previous in vitro studies have indicated that MUC2 promotes cancer growth and metastasis through a tumor-associated macrophage (TAM)-dependent mechanism...
  80. Kamel W, Akusjarvi G. An Ago2-associated capped transcriptional start site small RNA suppresses adenovirus DNA replication. RNA. 2017;23:1700-1711 pubmed publisher
    Here we show that the adenovirus major late promoter produces a 31-nucleotide transcriptional start site small RNA (MLP-TSS-sRNA) that retains the 7-methylguanosine (m7G)-cap and is incorporated onto Ago2-containing RNA-induced silencing ..
  81. Oliveira A, Lipinski C, Pereira E, Honorio K, Oliveira P, Weber K, et al. New consensus multivariate models based on PLS and ANN studies of sigma-1 receptor antagonists. J Mol Model. 2017;23:302 pubmed publisher
    ..746, MSEtest = 0.132 and MAEtest = 0.258). Additionally, multi-layer perceptron ANNs (MLP-ANNs) were employed in order to propose non-linear models trained by gradient descent with momentum backpropagation ..
  82. Choubin B, Darabi H, Rahmati O, Sajedi Hosseini F, Kløve B. River suspended sediment modelling using the CART model: A comparative study of machine learning techniques. Sci Total Environ. 2018;615:272-281 pubmed publisher
    ..e. adaptive neuro-fuzzy inference system (ANFIS), multi-layer perceptron (MLP) neural network and two kernels of support vector machines (RBF-SVM and P-SVM)...
  83. Zhang C, Zhao X, Yang L, Chen X, Jiang R, Jin S, et al. Resveratrol alleviates heat stress-induced impairment of intestinal morphology, microflora, and barrier integrity in broilers. Poult Sci. 2017;96:4325-4332 pubmed publisher
  84. Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, et al. Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB. Cell Rep. 2017;21:2090-2103 pubmed publisher
    The host metalloprotease meprin β is required for mucin 2 (MUC2) cleavage, which drives intestinal mucus detachment and prevents bacterial overgrowth...
  85. Hebbar V, Damera G, Sachdev G. Differential expression of MUC genes in endometrial and cervical tissues and tumors. BMC Cancer. 2005;5:124 pubmed
    ..The objective of this study was to investigate the expression of human MUC genes (MUC1, MUC2, MUC5B, MUC5AC and MUC8) in human endometrium and cervix, and to compare and quantitate the expression of MUC genes ..
  86. Yu X, Rong W, Xu F, Xu G, Sun Y, Feng M. [Expression and clinical significance of Mucin and E-cadherin in colorectal tumors]. Ai Zheng. 2007;26:1204-10 pubmed
    ..This study was to investigate the expression of MUC1, MUC2, MUC5AC and E-cad in different colorectal tumor tissues, and explore their correlations to clinicopathologic ..
  87. Yang H, Tamayo R, Almonte M, Horten B, DaSilva M, Gangi M, et al. Clinical significance of MUC1, MUC2 and CK17 expression patterns for diagnosis of pancreatobiliary arcinoma. Biotech Histochem. 2012;87:126-32 pubmed publisher
    ..We investigated the expression patterns of mucin 1 (MUC1), mucin 2 (MUC2) and cytokeratin 17 (CK17) in both normal tissues and metastatic adenocarcinomas using immunohistochemistry ..
  88. Wang J, El Bahrawy M. Expression profile of mucins (MUC1, MUC2, MUC5AC, and MUC6) in ovarian mucinous tumours: changes in expression from benign to malignant tumours. Histopathology. 2015;66:529-35 pubmed publisher
    ..MUC1, MUC2, MUC5AC and MUC6 expression was studied by immunohistochemistry in 53 OMTs (19 malignant, 25 borderline, and nine ..
  89. Sibila O, Garcia Bellmunt L, Giner J, Rodrigo Troyano A, Suarez Cuartin G, Torrego A, et al. Airway Mucin 2 Is Decreased in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization. Ann Am Thorac Soc. 2016;13:636-42 pubmed publisher
    ..Patients with bronchiectasis were excluded. Secreted mucins (MUC2, MUC5AC, and MUC5B) and inflammatory markers were assessed in BAL and sputum by ELISA...
  90. Boateng L, Nyarko R, Asante M, Steiner Asiedu M. Acceptability of Complementary Foods That Incorporate Moringa Oleifera Leaf Powder Among Infants and Their Caregivers. Food Nutr Bull. 2017;:379572117708656 pubmed publisher
    Moringa Oleifera leaf powder (MLP) is a nutrient-rich and readily available food resource that has the potential to improve the micronutrient quality of complementary foods in developing countries.
  91. Sato N, Sudo K, Mori M, Imai C, Muramatsu M, Sugimoto M. Early gestational maternal low-protein diet diminishes hepatic response to fasting in young adult male mice. Sci Rep. 2017;7:9812 pubmed publisher
    Maternal low-protein (MLP) diet can lead to hepatic steatosis, which only develops with ageing. It is still unclear whether the young offspring show any signs of past exposure to prenatal adverse conditions...
  92. Tamouridou A, Alexandridis T, Pantazi X, Lagopodi A, Kashefi J, Kasampalis D, et al. Application of Multilayer Perceptron with Automatic Relevance Determination on Weed Mapping Using UAV Multispectral Imagery. Sensors (Basel). 2017;17: pubmed publisher
    ..1 m resolution). The Multilayer Perceptron with Automatic Relevance Determination (MLP-ARD) was used to identify the S. marianum among other vegetation, mostly Avena sterilis L...