MUC13

Summary

Gene Symbol: MUC13
Description: mucin 13, cell surface associated
Alias: DRCC1, MUC-13, mucin-13, down-regulated in colon cancer 1, mucin 13, epithelial transmembrane
Species: human
Products:     MUC13

Top Publications

  1. Shimamura T, Ito H, Shibahara J, Watanabe A, Hippo Y, Taniguchi H, et al. Overexpression of MUC13 is associated with intestinal-type gastric cancer. Cancer Sci. 2005;96:265-73 pubmed
    ..Here we show that transmembrane mucin MUC13 is upregulated in gastric cancer...
  2. Maher D, Gupta B, Nagata S, Jaggi M, Chauhan S. Mucin 13: structure, function, and potential roles in cancer pathogenesis. Mol Cancer Res. 2011;9:531-537 pubmed publisher
    b>Mucin 13 (MUC13) is a high-molecular-weight transmembrane glycoprotein that is frequently and aberrantly expressed in a variety of epithelial carcinomas, including gastric, colorectal, and ovarian cancers...
  3. Gupta B, Maher D, Ebeling M, Sundram V, Koch M, Lynch D, et al. Increased expression and aberrant localization of mucin 13 in metastatic colon cancer. J Histochem Cytochem. 2012;60:822-31 pubmed publisher
    b>MUC13 is a newly identified transmembrane mucin. Although MUC13 is known to be overexpressed in ovarian and gastric cancers, limited information is available regarding the expression of MUC13 in metastatic colon cancer...
  4. Chauhan S, Vannatta K, Ebeling M, Vinayek N, Watanabe A, Pandey K, et al. Expression and functions of transmembrane mucin MUC13 in ovarian cancer. Cancer Res. 2009;69:765-74 pubmed publisher
    b>MUC13, a transmembrane mucin, is normally expressed in gastrointestinal and airway epithelium. Its aberrant expression has been correlated with gastric colon and cancer...
  5. Chauhan S, Ebeling M, Maher D, Koch M, Watanabe A, Aburatani H, et al. MUC13 mucin augments pancreatic tumorigenesis. Mol Cancer Ther. 2012;11:24-33 pubmed publisher
    ..Although MUC13, a newly identified transmembrane mucin, is known to be aberrantly expressed in ovarian and gastro-intestinal ..
  6. Williams S, Wreschner D, Tran M, Eyre H, Sutherland G, McGuckin M. Muc13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells. J Biol Chem. 2001;276:18327-36 pubmed
    ..We determined the cDNA sequence of the human orthologue of this gene, MUC13, which localizes to chromosome band 3q13.3 and generates 3...
  7. Kasprzak A, Adamek A. Mucins: the Old, the New and the Promising Factors in Hepatobiliary Carcinogenesis. Int J Mol Sci. 2019;20: pubmed publisher
    ..Mucins may act as oncogenes and tumour-promoting (e.g., MUC1, MUC13), and/or tumour-suppressing factors (e.g., MUC15)...
  8. Talbot N, Shannon A, Garrett W. Pancreatic duct-like cell line derived from pig embryonic stem cells: expression of uroplakin genes in pig pancreatic tissue. In Vitro Cell Dev Biol Anim. 2019;55:285-301 pubmed publisher
    ..Pancreas ductal cell-associated genes including CA2, CFTR, MUC1, MUC5B, MUC13, SHH, TFF1, KRT8, and KRT19 were expressed by the PICM-31D cells, but the exocrine pancreas marker genes, CPA1 and ..
  9. Lamonte G, Orjuela Sánchez P, Calla J, Wang L, Li S, Swann J, et al. Dual RNA-seq identifies human mucosal immunity protein Mucin-13 as a hallmark of Plasmodium exoerythrocytic infection. Nat Commun. 2019;10:488 pubmed publisher
    ..of flow-sorted infected and uninfected hepatoma cells we show that the human mucosal immunity gene, mucin-13 (MUC13), is strongly upregulated during Plasmodium exoerythrocytic hepatic-stage infection...

More Information

Publications38

  1. Reynolds I, Fichtner M, McNamara D, Kay E, Prehn J, Burke J. Mucin glycoproteins block apoptosis; promote invasion, proliferation, and migration; and cause chemoresistance through diverse pathways in epithelial cancers. Cancer Metastasis Rev. 2019;: pubmed publisher
    ..The studies included details on MUC1, MUC2, MUC4, MUC5AC, MUC5B, MUC13, and MUC16. The majority of studies evaluated MUC1...
  2. Stiles Z, Khan S, Patton K, Jaggi M, Behrman S, Chauhan S. Transmembrane mucin MUC13 distinguishes intraductal papillary mucinous neoplasms from non-mucinous cysts and is associated with high-risk lesions. HPB (Oxford). 2019;21:87-95 pubmed publisher
    ..This study was designed to determine if MUC13, a glycoprotein aberrantly overexpressed in pancreatic adenocarcinoma, might aid in distinguishing high-risk ..
  3. Zolotova N, Polikarpova A, Khochanskii D, Makarova O, Mikhailova L. Expression of Mucins and Claudins in the Colon during Acute and Chronic Experimental Colitis. Bull Exp Biol Med. 2018;165:434-437 pubmed publisher
    ..mucus component Muc2, enhanced of expression of Muc1 associated with carcinogenesis, and reduced expression of Muc13, which led to a more severe course of colitis; the expression of pore-forming claudin Cldn2 was elevated...
  4. Mito K, Saito M, Morita K, Maetani I, Sata N, Mieno M, et al. Clinicopathological and prognostic significance of MUC13 and AGR2 expression in intraductal papillary mucinous neoplasms of the pancreas. Pancreatology. 2018;18:407-412 pubmed publisher
    ..We evaluated the immunohistochemical expression of MUC13, AGR2, FUT8, and FXYD3, which were previously reported to be overexpressed in pancreatic ductal adenocarcinoma...
  5. Bengtsson R, MacIntyre N, Guthrie J, Wilson A, Finlayson H, Matika O, et al. Lawsonia intracellularis infection of intestinal crypt cells is associated with specific depletion of secreted MUC2 in goblet cells. Vet Immunol Immunopathol. 2015;168:61-7 pubmed publisher
    The expression patterns of secreted (MUC2 and MUC5AC) and membrane-tethered (MUC1, MUC4, MUC12 and MUC13) mucins were monitored in healthy pigs and pigs challenged orally with Lawsonia intracellularis...
  6. Saraiva Pava K, Navabi N, Skoog E, Lindén S, Oleastro M, Roxo Rosa M. New NCI-N87-derived human gastric epithelial line after human telomerase catalytic subunit over-expression. World J Gastroenterol. 2015;21:6526-42 pubmed publisher
    ..Both clones were shown to produce high amounts of MUC1, MUC2 and MUC13. NCI-hTERT-CL5 mucins were shown to be decorated with blood group H type 2 (BG-H), Lewis-x (Le(x)), Le(y) and Le(a)..
  7. Khan S, Zafar N, Khan S, Setua S, Behrman S, Stiles Z, et al. Clinical significance of MUC13 in pancreatic ductal adenocarcinoma. HPB (Oxford). 2018;20:563-572 pubmed publisher
    ..This study elucidates significance of MUC13, as a diagnostic/prognostic marker of PanCa...
  8. Sheng Y, He Y, Hasnain S, Wang R, Tong H, Clarke D, et al. MUC13 protects colorectal cancer cells from death by activating the NF-?B pathway and is a potential therapeutic target. Oncogene. 2017;36:700-713 pubmed publisher
    b>MUC13 is a transmembrane mucin glycoprotein that is over produced by many cancers, although its functions are not fully understood...
  9. Kumari S, Khan S, Gupta S, Kashyap V, Yallapu M, Chauhan S, et al. MUC13 contributes to rewiring of glucose metabolism in pancreatic cancer. Oncogenesis. 2018;7:19 pubmed publisher
    ..Recently, we have shown that MUC13, which is highly expressed in pancreatic tumors, promotes tumor progression via modulation of HER2 receptor ..
  10. Shen L, Wang H, Dong B, Yan W, Lin Y, Shi Q, et al. Possible prediction of the response of esophageal squamous cell carcinoma to neoadjuvant chemotherapy based on gene expression profiling. Oncotarget. 2016;7:4531-41 pubmed publisher
    ..IHC was conducted to examine the expression of selected target markers MUC4, MUC13, and MUC20 in 186 ESCC resection samples and the relationships between their expression and tumor regression grade ..
  11. Wang R, Yu C, Zhao D, Wu M, Yang Z. The mucin-type glycosylating enzyme polypeptide N-acetylgalactosaminyltransferase 14 promotes the migration of ovarian cancer by modifying mucin 13. Oncol Rep. 2013;30:667-76 pubmed publisher
    ..and western blot analyses indicated that GALNT14 contributed to the glycosylation of transmembrane mucin 13 (MUC13), which was significantly higher in ovarian cancer cells compared with the normal/benign ovary tissues...
  12. van den Kieboom C, Ahout I, Zomer A, Brand K, De Groot R, Ferwerda G, et al. Nasopharyngeal gene expression, a novel approach to study the course of respiratory syncytial virus infection. Eur Respir J. 2015;45:718-25 pubmed publisher
    ..was profiled by microarray studies, resulting in the selection of five genes: ubiquitin D, tetraspanin 8, mucin 13, β-microseminoprotein and chemokine ligand 7...
  13. Khan S, Ebeling M, Zaman M, Sikander M, Yallapu M, Chauhan N, et al. MicroRNA-145 targets MUC13 and suppresses growth and invasion of pancreatic cancer. Oncotarget. 2014;5:7599-609 pubmed
    Pancreatic cancer has a poor prognosis due to late diagnosis and ineffective therapeutic multimodality. MUC13, a transmembrane mucin is highly involved in pancreatic cancer progression...
  14. Gupta B, Maher D, Ebeling M, Stephenson P, Puumala S, Koch M, et al. Functions and regulation of MUC13 mucin in colon cancer cells. J Gastroenterol. 2014;49:1378-91 pubmed publisher
    b>MUC13 is overexpressed and aberrantly localized in colon cancer tissue; however, the specific functions and regulation of MUC13 expression are unknown...
  15. Dai Y, Liu L, Zeng T, Liang J, Song Y, Chen K, et al. Overexpression of MUC13, a Poor Prognostic Predictor, Promotes Cell Growth by Activating Wnt Signaling in Hepatocellular Carcinoma. Am J Pathol. 2018;188:378-391 pubmed publisher
    Recently RNA sequencing revealed high mucin 13 (MUC13) expression in hepatocellular carcinoma (HCC) tissues...
  16. Setua S, Khan S, Yallapu M, Behrman S, Sikander M, Khan S, et al. Restitution of Tumor Suppressor MicroRNA-145 Using Magnetic Nanoformulation for Pancreatic Cancer Therapy. J Gastrointest Surg. 2017;21:94-105 pubmed publisher
    ..The restoration of miR-145 downregulates a number of oncogenes including mucin MUC13, a transmembrane glycoprotein that is aberrantly expressed in pancreatic cancer, thus efficiently inhibiting tumor ..
  17. Khan S, Sikander M, Ebeling M, Ganju A, Kumari S, Yallapu M, et al. MUC13 interaction with receptor tyrosine kinase HER2 drives pancreatic ductal adenocarcinoma progression. Oncogene. 2017;36:491-500 pubmed publisher
    Although MUC13, a transmembrane mucin, is aberrantly expressed in pancreatic ductal adenocarcinoma (PDAC) and generally correlates with increased expression of HER2, the underlying mechanism remains poorly understood...
  18. Wang H, Shen L, Lin Y, Shi Q, Yang Y, Chen K. The expression and prognostic significance of Mucin 13 and Mucin 20 in esophageal squamous cell carcinoma. J Cancer Res Ther. 2015;11 Suppl 1:C74-9 pubmed publisher
    b>Mucin 13 (MUC13) and Mucin 20 (MUC20) are high molecular weight transmembrane O-linked glycoprotein secreted by epithelium and are widely overexpressed in epithelial tumor cells...
  19. Xu Z, Liu Y, Yang Y, Wang J, Zhang G, Liu Z, et al. High expression of Mucin13 associates with grimmer postoperative prognosis of patients with non-metastatic clear-cell renal cell carcinoma. Oncotarget. 2017;8:7548-7558 pubmed publisher
    Mucin13 (MUC13) is a transmembrane glycoprotein that is aberrantly expressed in ovarian and gastro-intestinal tumors, but its role in renal cell carcinoma remains elusive...
  20. Moehle C, Ackermann N, Langmann T, Aslanidis C, Kel A, Kel Margoulis O, et al. Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease. J Mol Med (Berl). 2006;84:1055-66 pubmed
    ..003) polymorphism with CD and for MUC4-A585S (P = 0.025), as well as MUC13-R502S (P = 0.0003) with UC...
  21. Ren X, Zhu Y, Gamallat Y, Ma S, Chiwala G, Meyiah A, et al. E. coli O124 K72 alters the intestinal barrier and the tight junctions proteins of guinea pig intestine. Biomed Pharmacother. 2017;94:468-473 pubmed publisher
    ..In addition, E. coli upregulated the mRNA expression of MUC1, MUC2, MUC13 and MUC15. Furthermore, suspected tumor was found in the E. coli treated animals. Our results suggested that E...
  22. Carr J, Sherman S, Wang D, Dahdaleh F, Bellizzi A, O DORISIO M, et al. Overexpression of membrane proteins in primary and metastatic gastrointestinal neuroendocrine tumors. Ann Surg Oncol. 2013;20 Suppl 3:S739-S746 pubmed publisher
    ..Significant overexpression was observed for MUC13 and MEP1B in PNET primary tumors, and for GPR113 in primary SBNETs and their metastases...
  23. Sampson M, Robertson C, Martini S, Mariani L, Lemley K, Gillies C, et al. Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects. J Am Soc Nephrol. 2016;27:814-23 pubmed publisher
    ..level of five genes associated with the high-risk genotype (CXCL9, CXCL11, and UBD in glomerulus; SNOR14B and MUC13 in tubulointerstitium)...
  24. Nishii Y, Yamaguchi M, Kimura Y, Hasegawa T, Aburatani H, Uchida H, et al. A newly developed anti-Mucin 13 monoclonal antibody targets pancreatic ductal adenocarcinoma cells. Int J Oncol. 2015;46:1781-7 pubmed publisher
    ..The mAb, designated TCC56, recognized Mucin 13 (MUC13), while TCC56‑DT3C conjugates induced cell death in TCC-PAN2 cells expressing MUC13...
  25. Samuels T, Handler E, Syring M, Pajewski N, Blumin J, Kerschner J, et al. Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux. Ann Otol Rhinol Laryngol. 2008;117:688-95 pubmed
    ..These mucin genes were up-regulated after exposure to low pH in vitro (p < 0.005). Pepsin inhibited this up-regulation (p <0.001). Reflux laryngitis is associated with down-regulation of mucin gene expression. ..
  26. Wang H, Tachibana K, Zhang Y, Iwasaki H, Kameyama A, Cheng L, et al. Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14. Biochem Biophys Res Commun. 2003;300:738-44 pubmed
    ..pp-GalNAc-T14 transferred GalNAc to a panel of mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58)...
  27. He L, Qu L, Wei L, Chen Y, Suo J. Reduction of miR?132?3p contributes to gastric cancer proliferation by targeting MUC13. Mol Med Rep. 2017;15:3055-3061 pubmed publisher
    ..present study focused on the miRNAs that regulate human epidermal growth factor receptor (HER) activation through mucin 13 (MUC13)...
  28. Sheng Y, Ng C, Lourie R, Shah E, He Y, Wong K, et al. MUC13 overexpression in renal cell carcinoma plays a central role in tumor progression and drug resistance. Int J Cancer. 2017;140:2351-2363 pubmed publisher
    ..Here we reveal that MUC13, a cell surface mucin glycoprotein, is aberrantly expressed by most renal cell carcinomas, with increasing ..
  29. Sung H, Park A, Ju W, Ahn J. Overexpression of mucin 13 due to promoter methylation promotes aggressive behavior in ovarian cancer cells. Yonsei Med J. 2014;55:1206-13 pubmed publisher
    ..gene products involved in ovarian cancer metastasis, we examined the mechanisms regulating mucin 13 (MUC13) expression and its influence on aggressive behaviors of ovarian malignancies...