MUC1

Summary

Gene Symbol: MUC1
Description: mucin 1, cell surface associated
Alias: ADMCKD, ADMCKD1, CA 15-3, CD227, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM, mucin-1, H23 antigen, breast carcinoma-associated antigen DF3, cancer antigen 15-3, carcinoma-associated mucin, episialin, krebs von den Lungen-6, mucin 1, transmembrane, peanut-reactive urinary mucin, polymorphic epithelial mucin, tumor associated epithelial mucin, tumor-associated epithelial membrane antigen
Species: human
Products:     MUC1

Top Publications

  1. Ahmad R, Raina D, Trivedi V, Ren J, Rajabi H, Kharbanda S, et al. MUC1 oncoprotein activates the IkappaB kinase beta complex and constitutive NF-kappaB signalling. Nat Cell Biol. 2007;9:1419-27 pubmed
    ..The MUC1 oncoprotein is aberrantly overexpressed by most human carcinomas and, similarly to NF-kappaB, blocks apoptosis and ..
  2. Raina D, Ahmad R, Kumar S, Ren J, Yoshida K, Kharbanda S, et al. MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage. EMBO J. 2006;25:3774-83 pubmed
    ..The MUC1 oncoprotein is overexpressed by most human carcinomas and blocks the induction of apoptosis by genotoxic agents...
  3. Ren J, Agata N, Chen D, Li Y, Yu W, Huang L, et al. Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents. Cancer Cell. 2004;5:163-75 pubmed
    The MUC1 transforming protein is overexpressed by most human carcinomas...
  4. Aubert S, Fauquette V, Hemon B, Lepoivre R, Briez N, Bernard D, et al. MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression. Cancer Res. 2009;69:5707-15 pubmed publisher
    The hypoxia inducible factor (HIF) signaling pathway is known as the main renal carcinogenetic pathway. MUC1, an O-glycoprotein membrane-bound mucin, is overexpressed in clear renal cell carcinomas (cRCC) with correlation to two major ..
  5. Engelmann K, Shen H, Finn O. MCF7 side population cells with characteristics of cancer stem/progenitor cells express the tumor antigen MUC1. Cancer Res. 2008;68:2419-26 pubmed publisher
    ..This study aimed to determine if one well-known tumor antigen, MUC1, which is being tested as an immunotherapy target on tumor cells, is also expressed on the quiescent cancer stem/..
  6. Xu Y, Zhang L, Hu G. Potential application of alternatively glycosylated serum MUC1 and MUC5AC in gastric cancer diagnosis. Biologicals. 2009;37:18-25 pubmed publisher
    ..enzyme immunoassays were utilized to explore the clinical diagnostic value of the alternatively glycosylated MUC1 and MUC5AC. Four pairs of antibodies were selected to construct quantitative sandwich enzyme immunoassay...
  7. Roy L, Sahraei M, Subramani D, Besmer D, Nath S, Tinder T, et al. MUC1 enhances invasiveness of pancreatic cancer cells by inducing epithelial to mesenchymal transition. Oncogene. 2011;30:1449-59 pubmed publisher
    ..However, the mechanisms that regulate this activation in pancreatic tumors remain elusive. MUC1, a transmembrane mucin glycoprotein, is associated with the most invasive forms of pancreatic ductal ..
  8. Park Y, Guang W, Blanchard T, Kim K, Lillehoj E. Suppression of IL-8 production in gastric epithelial cells by MUC1 mucin and peroxisome proliferator-associated receptor-?. Am J Physiol Gastrointest Liver Physiol. 2012;303:G765-74 pubmed publisher
    b>MUC1 is a membrane-tethered mucin expressed on the apical surface of epithelial cells. Our previous report (Guang W, Ding H, Czinn SJ, Kim KC, Blanchard TG, Lillehoj EP...
  9. Li F, Zhong M, Li J, Liu W, Li B. Case-control study of single nucleotide polymorphisms of PSCA and MUC1 genes with gastric cancer in a Chinese. Asian Pac J Cancer Prev. 2012;13:2593-6 pubmed
    ..patients and 300 controls was conducted to investigate whether the polymorphisms rs2294008 in PSCA and rs2070803 in MUC1 might be associated with risk of gastric cancer in a Chinese population...

More Information

Publications85

  1. Zheng L, Zhu C, Gu J, Xi P, Du J, Jin G. Functional polymorphism rs4072037 in MUC1 gene contributes to the susceptibility to gastric cancer: evidence from pooled 6,580 cases and 10,324 controls. Mol Biol Rep. 2013;40:5791-6 pubmed publisher
    ..This variant was associated with altered physiological function of MUC1 possibly by modulating promoter activity and alternative splicing of MUC1...
  2. Remmers N, Anderson J, Linde E, Dimaio D, Lazenby A, Wandall H, et al. Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer. Clin Cancer Res. 2013;19:1981-93 pubmed publisher
    ..There were significant changes in mucin expression patterns throughout disease progression. MUC1 and MUC4 were differentially glycosylated as the disease progressed from early pancreatic intraepithelial ..
  3. Budiu R, Mantia Smaldone G, Elishaev E, Chu T, Thaller J, McCabe K, et al. Soluble MUC1 and serum MUC1-specific antibodies are potential prognostic biomarkers for platinum-resistant ovarian cancer. Cancer Immunol Immunother. 2011;60:975-84 pubmed publisher
    b>MUC1 (CA15-3) and MUC16 (CA125) tumor-associated antigens are upregulated in ovarian cancer and can be detected in patients' sera by standardized tests...
  4. Fanni D, Fanos V, Monga G, Gerosa C, Nemolato S, Locci A, et al. MUC1 in mesenchymal-to-epithelial transition during human nephrogenesis: changing the fate of renal progenitor/stem cells?. J Matern Fetal Neonatal Med. 2011;24 Suppl 2:63-6 pubmed publisher
    ..The expression of MUC1 was evaluated in the kidneys, of 4 human foetuses and 2 newborns...
  5. Rajabi H, Joshi M, Jin C, Ahmad R, Kufe D. Androgen receptor regulates expression of the MUC1-C oncoprotein in human prostate cancer cells. Prostate. 2011;71:1299-308 pubmed publisher
    The MUC1 heterodimeric oncoprotein is aberrantly overexpressed in human prostate cancers with more aggressive pathologic and clinical features...
  6. ARGUESO P, Guzman Aranguez A, Mantelli F, Cao Z, Ricciuto J, Panjwani N. Association of cell surface mucins with galectin-3 contributes to the ocular surface epithelial barrier. J Biol Chem. 2009;284:23037-45 pubmed publisher
    ..of the eye as a model system, we found that galectin-3 colocalized with two distinct membrane-associated mucins, MUC1 and MUC16, on the apical surface of epithelial cells and that both mucins bound to galectin-3 affinity columns in a ..
  7. Ishikawa N, Hattori N, Yokoyama A, Kohno N. Utility of KL-6/MUC1 in the clinical management of interstitial lung diseases. Respir Investig. 2012;50:3-13 pubmed publisher
    ..KL-6 is now classified as a human MUC1 mucin protein, and regenerating type II pneumocytes are the primary cellular source of KL-6/MUC1 in the affected ..
  8. Patriarca C, Colombo P, Pio Taronna A, Wesseling J, Franchi G, Guddo F, et al. Cell discohesion and multifocality of carcinoma in situ of the bladder: new insight from the adhesion molecule profile (e-cadherin, Ep-CAM, and MUC1). Int J Surg Pathol. 2009;17:99-106 pubmed publisher
    ..Ep-CAM was present in all the cases with a heterogeneous staining pattern. Similarly, MUC1/episialin was variously present in 94% of the cases without a polarized staining pattern and was expressed more strongly ..
  9. Cascio S, Zhang L, Finn O. MUC1 protein expression in tumor cells regulates transcription of proinflammatory cytokines by forming a complex with nuclear factor-?B p65 and binding to cytokine promoters: importance of extracellular domain. J Biol Chem. 2011;286:42248-56 pubmed publisher
    b>MUC1 is a transmembrane glycoprotein abnormally expressed in all stages of development of human adenocarcinomas...
  10. Ahmad R, Raina D, Joshi M, Kawano T, Ren J, Kharbanda S, et al. MUC1-C oncoprotein functions as a direct activator of the nuclear factor-kappaB p65 transcription factor. Cancer Res. 2009;69:7013-21 pubmed publisher
    Nuclear factor-kappaB (NF-kappaB) is constitutively activated in diverse human malignancies. The mucin 1 (MUC1) oncoprotein is overexpressed in human carcinomas and, like NF-kappaB, blocks cell death and induces transformation...
  11. Guang W, Czinn S, Blanchard T, Kim K, Lillehoj E. Genetic regulation of MUC1 expression by Helicobacter pylori in gastric cancer cells. Biochem Biophys Res Commun. 2014;445:145-50 pubmed publisher
    ..b>MUC1 is aberrantly overexpressed by more than 50% of stomach cancers, but its role in carcinogenesis remains to be ..
  12. Ohtsuki Y, Fujita J, Hachisuka Y, Uomoto M, Okada Y, Yoshinouchi T, et al. Immunohistochemical and immunoelectron microscopic studies of the localization of KL-6 and epithelial membrane antigen (EMA) in presumably normal pulmonary tissue and in interstitial pneumonia. Med Mol Morphol. 2007;40:198-202 pubmed
    To clarify the localization of KL-6 and epithelial membrane antigen (EMA) in human lungs, immune reactions to antibodies to these factors were examined in detail at light and electron microscopic levels...
  13. Hasegawa H, Komoda M, Yamada Y, Yonezawa S, Tsutsumida H, Nagai K, et al. Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/lymphoma cells. Leuk Lymphoma. 2011;52:1108-17 pubmed publisher
    Aberrant overexpression of membrane-associated mucin (MUC1) is implicated in the pathogenesis of cancer, particularly of adenocarcinomas...
  14. Dharmaraj N, Wang P, Carson D. Cytokine and progesterone receptor interplay in the regulation of MUC1 gene expression. Mol Endocrinol. 2010;24:2253-66 pubmed publisher
    b>Mucin 1 (MUC1), a transmembrane mucin expressed at the apical surface of uterine epithelia, is a barrier to microbial infection and enzymatic attack...
  15. Kawase S, Hattori N, Ishikawa N, Horimasu Y, Fujitaka K, Furonaka O, et al. Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease. Respir Res. 2011;12:97 pubmed publisher
    ..The results of this study strongly support the potential of KL-6 as a diagnostic biomarker for life-threatening EGFR-TKIs induced ILD. Monitoring of KL-6 is also useful to evaluate the progression and severity of EGFR-TKIs induced ILD. ..
  16. Raina D, Kosugi M, Ahmad R, Panchamoorthy G, Rajabi H, Alam M, et al. Dependence on the MUC1-C oncoprotein in non-small cell lung cancer cells. Mol Cancer Ther. 2011;10:806-16 pubmed publisher
    ..The mucin 1 (MUC1) heterodimeric glycoprotein is aberrantly overexpressed in NSCLC cells and induces gene signatures that are ..
  17. Benjamin J, Jayanthi V, Devaraj H. MUC1 expression and its association with other aetiological factors and localization to mitochondria in preneoplastic and neoplastic gastric tissues. Clin Chim Acta. 2010;411:2067-72 pubmed publisher
    ..b>MUC1 overexpression and localization in mitochondria might confer cancer cells with attenuation of stress induced ..
  18. Zhao Q, Barclay M, Hilkens J, Guo X, Barrow H, Rhodes J, et al. Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis. Mol Cancer. 2010;9:154 pubmed publisher
    ..carbohydrate (Galbeta1,3GalNAcalpha-, TF) antigen on the cancer-associated transmembrane mucin protein MUC1. The galectin-3-MUC1 interaction induces MUC1 cell surface polarization and exposure of the cell surface adhesion ..
  19. Xu Q, Yuan Y, Sun L, Gong Y, Xu Y, Yu X, et al. Risk of gastric cancer is associated with the MUC1 568 A/G polymorphism. Int J Oncol. 2009;35:1313-20 pubmed
    Identifying the genetic variants that alter MUC1 protein expression may further our understanding of the risk for development of gastric cancer (GC)...
  20. Palmer A, Lochhead P, Hold G, Rabkin C, Chow W, Lissowska J, et al. Genetic variation in C20orf54, PLCE1 and MUC1 and the risk of upper gastrointestinal cancers in Caucasian populations. Eur J Cancer Prev. 2012;21:541-4 pubmed
    ..upper gastrointestinal cancer and the rs2274223, rs13042395 and rs4072037 polymorphisms in PLCE1, C20orf54 and MUC1, respectively. We aimed to determine whether similar associations existed for Caucasian populations...
  21. Ahmad R, Alam M, Rajabi H, Kufe D. The MUC1-C oncoprotein binds to the BH3 domain of the pro-apoptotic BAX protein and blocks BAX function. J Biol Chem. 2012;287:20866-75 pubmed publisher
    ..The MUC1 (mucin 1) heterodimeric protein is overexpressed in diverse human carcinomas and blocks apoptosis in the response to ..
  22. Horimasu Y, Hattori N, Ishikawa N, Kawase S, Tanaka S, Yoshioka K, et al. Different MUC1 gene polymorphisms in German and Japanese ethnicities affect serum KL-6 levels. Respir Med. 2012;106:1756-64 pubmed publisher
    KL-6 is a high-molecular-weight glycoprotein classified as human Mucin-1 (MUC1). KL-6 has been reported to be a sensitive biomarker for interstitial lung diseases (ILDs) in the Japanese population...
  23. Mahanta S, Fessler S, Park J, Bamdad C. A minimal fragment of MUC1 mediates growth of cancer cells. PLoS ONE. 2008;3:e2054 pubmed publisher
    The MUC1 protein is aberrantly expressed on many solid tumor cancers. In contrast to its apical clustering on healthy epithelial cells, it is uniformly distributed over cancer cells...
  24. Westgaard A, Schjølberg A, Cvancarova M, Eide T, Clausen O, Gladhaug I. Differentiation markers in pancreatic head adenocarcinomas: MUC1 and MUC4 expression indicates poor prognosis in pancreatobiliary differentiated tumours. Histopathology. 2009;54:337-47 pubmed publisher
    ..Immunohistochemistry for cytokeratin (CK) 7, CK20, MUC1, MUC2, MUC4 and CDX2 was performed on tissue microarrays...
  25. Imbert Y, Foulks G, Brennan M, Jumblatt M, John G, Shah H, et al. MUC1 and estrogen receptor alpha gene polymorphisms in dry eye patients. Exp Eye Res. 2009;88:334-8 pubmed publisher
    ..We reported that the frequency of non-Sjögren's aqueous-deficient dry eye patients expressing only the MUC1/A splice variant of the mucin MUC1 may be lower than that of a normal control group [Imbert, Y., Darling, D.S...
  26. Gao J, McConnell M, Yu B, Li J, Balko J, Black E, et al. MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion. Int J Oncol. 2009;35:337-45 pubmed
    ..One putative downstream gene regulated by Stat3 is MUC1 which also has important roles in tumorigenesis...
  27. Pitroda S, Khodarev N, Beckett M, Kufe D, Weichselbaum R. MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment. Proc Natl Acad Sci U S A. 2009;106:5837-41 pubmed publisher
    The mucin 1 (MUC1) oncoprotein is aberrantly overexpressed in human breast cancers...
  28. Linden S, Sheng Y, Every A, Miles K, Skoog E, Florin T, et al. MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy. PLoS Pathog. 2009;5:e1000617 pubmed publisher
    ..The cell-surface mucin MUC1 is a large glycoprotein which is highly expressed on the mucosal surface and limits the density of H...
  29. Radziejewska I, Borzym Kluczyk M, Namiot Z, Stefańska E. Glycosylation of mucins present in gastric juice: the effect of helicobacter pylori eradication treatment. Clin Exp Med. 2011;11:81-8 pubmed publisher
    ..Changes in the level of MUC 1 and MUC 5AC mucins and of carbohydrate structures, which are suggested to be receptors for Helicobacter pylori ..
  30. Jia Y, Persson C, Hou L, Zheng Z, Yeager M, Lissowska J, et al. A comprehensive analysis of common genetic variation in MUC1, MUC5AC, MUC6 genes and risk of stomach cancer. Cancer Causes Control. 2010;21:313-21 pubmed publisher
    b>MUC1, MUC5AC, and MUC6 are main constituents of the mucus barrier in the stomach, which protects the underlying epithelium from acid, proteases, mechanical trauma, and pathogenic microorganisms...
  31. Sellers T, Huang Y, Cunningham J, Goode E, Sutphen R, Vierkant R, et al. Association of single nucleotide polymorphisms in glycosylation genes with risk of epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2008;17:397-404 pubmed publisher
    Studies suggest that underglycosylation of the cell membrane mucin MUC1 may be associated with epithelial ovarian cancer...
  32. Suzuki Y, Sutoh M, Hatakeyama S, Mori K, Yamamoto H, Koie T, et al. MUC1 carrying core 2 O-glycans functions as a molecular shield against NK cell attack, promoting bladder tumor metastasis. Int J Oncol. 2012;40:1831-8 pubmed publisher
    ..of C2GnT in bladder tumors positively correlates with tumor progression and that bladder tumor cell-surface mucin 1 (MUC1) carrying core 2 O-glycans plays an important role in the evasion from natural killer (NK) cell attack...
  33. Merlin J, Stechly L, de Beaucé S, Monte D, Leteurtre E, Van Seuningen I, et al. Galectin-3 regulates MUC1 and EGFR cellular distribution and EGFR downstream pathways in pancreatic cancer cells. Oncogene. 2011;30:2514-25 pubmed publisher
    b>MUC1 is a transmembrane glycoprotein which is typically expressed at the apical membrane of normal epithelial cells...
  34. Caffery B, Heynen M, Joyce E, Jones L, Ritter R, Senchyna M. MUC1 expression in Sjogren's syndrome, KCS, and control subjects. Mol Vis. 2010;16:1720-7 pubmed
    To quantify and compare human mucin 1 (MUC1) protein and mRNA expression in tears and conjunctival epithelial cells collected from Sjogren's syndrome (SS), non-Sjogren's keratoconjunctivitus sicca (KCS) and non-dry eyed (NDE) control ..
  35. Inagaki Y, Tang W, Xu H, Nakata M, Mafune K, Konishi T, et al. Sustained aberrant localization of KL-6 mucin and beta-catenin at the invasion front of human gastric cancer cells. Anticancer Res. 2011;31:535-42 pubmed
    This study sought to analyze the clinicopathological significance of KL-6 mucin, a type of MUC1, in gastric cancer and its relationship to ?-catenin...
  36. Ahmad R, Rajabi H, Kosugi M, Joshi M, Alam M, Vasir B, et al. MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop. Sci Signal. 2011;4:ra9 pubmed publisher
    ..b>Mucin 1 (MUC1) is a heterodimeric cell surface glycoprotein that is overexpressed in human carcinomas and, like STAT3, ..
  37. Kharbanda A, Rajabi H, Jin C, Raina D, Kufe D. Oncogenic MUC1-C promotes tamoxifen resistance in human breast cancer. Mol Cancer Res. 2013;11:714-23 pubmed publisher
    ..b>Mucin 1 (MUC1) is aberrantly overexpressed in about 90% of human breast cancers, and the oncogenic MUC1-C subunit is ..
  38. Tamura Y, Higashi M, Kitamoto S, Yokoyama S, Osako M, Horinouchi M, et al. MUC4 and MUC1 expression in adenocarcinoma of the stomach correlates with vessel invasion and lymph node metastasis: an immunohistochemical study of early gastric cancer. PLoS ONE. 2012;7:e49251 pubmed publisher
    ..Our previous study also showed that MUC1 expression in gastric cancers, including the early and advanced stages is a poor prognostic factor...
  39. Shen Q, Rahn J, Zhang J, Gunasekera N, Sun X, Shaw A, et al. MUC1 initiates Src-CrkL-Rac1/Cdc42-mediated actin cytoskeletal protrusive motility after ligating intercellular adhesion molecule-1. Mol Cancer Res. 2008;6:555-67 pubmed publisher
    b>MUC1, a transmembrane glycoprotein of the mucin family, when aberrantly expressed on breast cancer cells is correlated with increased lymph node metastases...
  40. Kawano T, Ahmad R, Nogi H, Agata N, Anderson K, Kufe D. MUC1 oncoprotein promotes growth and survival of human multiple myeloma cells. Int J Oncol. 2008;33:153-9 pubmed
    The MUC1 oncoprotein is aberrantly expressed in human multiple myeloma cells by mechanisms that are not understood. Moreover, the functional role of MUC1 in multiple myeloma is not known...
  41. Singh P, Behrens M, Eggers J, Cerny R, Bailey J, Shanmugam K, et al. Phosphorylation of MUC1 by Met modulates interaction with p53 and MMP1 expression. J Biol Chem. 2008;283:26985-95 pubmed publisher
    b>MUC1, a transmembrane mucin, is a key modulator of several signaling pathways that affect oncogenesis, motility, and cell morphology...
  42. Hikita S, Kosik K, Clegg D, Bamdad C. MUC1* mediates the growth of human pluripotent stem cells. PLoS ONE. 2008;3:e3312 pubmed publisher
    The MUC1 protein is aberrantly expressed on an estimated 75% of all human solid tumor cancers. We recently reported that a transmembrane cleavage product, MUC1*, is the predominant form of the protein on cancer cells [1]...
  43. Guang W, Kim K, Lillehoj E. MUC1 mucin interacts with calcium-modulating cyclophilin ligand. Int J Biochem Cell Biol. 2009;41:1354-60 pubmed publisher
    b>MUC1 is an integral membrane glycoprotein expressed on epithelial and hematopoietic cells with a COOH-terminus (CT) that mediates intracellular signal transduction...
  44. Siroy A, Abdul Karim F, Miedler J, Fong N, Fu P, Gilmore H, et al. MUC1 is expressed at high frequency in early-stage basal-like triple-negative breast cancer. Hum Pathol. 2013;44:2159-66 pubmed publisher
    ..b>MUC1 is a tumor antigen expressed on adenocarcinomas and represents an ideal target for MUC1-based vaccination...
  45. Alam M, Rajabi H, Ahmad R, Jin C, Kufe D. Targeting the MUC1-C oncoprotein inhibits self-renewal capacity of breast cancer cells. Oncotarget. 2014;5:2622-34 pubmed
    ..The present studies demonstrate that silencing expression of the MUC1-C oncoprotein inhibits growth of luminal MCF-7 and HER2-overexpressing SKBR3 breast cancer cells as mammospheres...
  46. Liu X, Yuan Z, Chung M. MUC1 intra-cellular trafficking is clathrin, dynamin, and rab5 dependent. Biochem Biophys Res Commun. 2008;376:688-93 pubmed publisher
    b>MUC1, a transmembrane glycoprotein, is abnormally over-expressed in most human adenocarcinomas. MUC1 association with cytoplasmic cell signal regulators and nuclear accumulation are important for its tumor related activities...
  47. Marín F, Bonet C, Munoz X, Garcia N, Pardo M, Ruiz Liso J, et al. Genetic variation in MUC1, MUC2 and MUC6 genes and evolution of gastric cancer precursor lesions in a long-term follow-up in a high-risk area in Spain. Carcinogenesis. 2012;33:1072-80 pubmed publisher
    ..mucin genes associates with the evolution of gastric cancer precursor lesions (GCPLs), we genotyped 22 tagSNPs in MUC1, MUC6 and MUC2 genes of 387 patients with GCPLs that had been followed up for 12.8 years...
  48. Raina D, Ahmad R, Rajabi H, Panchamoorthy G, Kharbanda S, Kufe D. Targeting cysteine-mediated dimerization of the MUC1-C oncoprotein in human cancer cells. Int J Oncol. 2012;40:1643-9 pubmed publisher
    The MUC1 heterodimeric protein is aberrantly overexpressed in diverse human carcinomas and contributes to the malignant phenotype...
  49. Silk A, Schoen R, Potter D, Finn O. Humoral immune response to abnormal MUC1 in subjects with colorectal adenoma and cancer. Mol Immunol. 2009;47:52-6 pubmed publisher
    Colorectal cancer (CRC) expresses a hypoglycosylated (abnormal) form of MUC1 different than MUC1 expressed in normal colon, which elicits antibodies in patients with CRC...
  50. Ng W, Loh A, Teixeira A, Pereira S, Swallow D. Genetic regulation of MUC1 alternative splicing in human tissues. Br J Cancer. 2008;99:978-85 pubmed publisher
    The membrane mucin MUC1 is aberrantly expressed in a variety of cancers, and in stomach, it is a ligand for Helicobacter pylori where it plays a role in gastric carcinogenesis...
  51. Mehla K, Singh P. MUC1: a novel metabolic master regulator. Biochim Biophys Acta. 2014;1845:126-35 pubmed publisher
    b>MUC1, a type I transmembrane protein, is significantly overexpressed and aberrantly glycosylated in tumors of epithelial origin...
  52. Bitler B, Goverdhan A, Schroeder J. MUC1 regulates nuclear localization and function of the epidermal growth factor receptor. J Cell Sci. 2010;123:1716-23 pubmed publisher
    ..We have previously established that loss of MUC1 in an EGFR-dependent transgenic mouse model of breast cancer correlates with the loss of cyclin D1 expression...
  53. Beatson R, Taylor Papadimitriou J, Burchell J. MUC1 immunotherapy. Immunotherapy. 2010;2:305-27 pubmed publisher
    The overexpression and aberrant glycosylation of MUC1 is associated with a wide variety of cancers, making it an ideal target for immunotherapeutic strategies...
  54. Lacunza E, Baudis M, Colussi A, Segal Eiras A, Croce M, Abba M. MUC1 oncogene amplification correlates with protein overexpression in invasive breast carcinoma cells. Cancer Genet Cytogenet. 2010;201:102-10 pubmed publisher
    The MUC1 gene is aberrantly overexpressed in approximately 90% of human breast cancers. Several studies have shown that MUC1 overexpression is due to transcriptional regulatory events...
  55. Zhang S, Hu Y, Qian H, Jiao S, Liu Z, Tao H, et al. Expression and significance of ER, PR, VEGF, CA15-3, CA125 and CEA in judging the prognosis of breast cancer. Asian Pac J Cancer Prev. 2013;14:3937-40 pubmed
    ..01). Joint detection of ER and PR expression as well as levels of serum VEGF, CA15-3, CA125 and CEA is meaningful and can guide the diagnosis and treatment for breast cancer. ..
  56. Khodarev N, Pitroda S, Beckett M, Macdermed D, Huang L, Kufe D, et al. MUC1-induced transcriptional programs associated with tumorigenesis predict outcome in breast and lung cancer. Cancer Res. 2009;69:2833-7 pubmed publisher
    The Mucin 1 (MUC1) oncoprotein is aberrantly overexpressed in diverse human malignancies including breast and lung cancer...
  57. Costa N, Mendes N, Marcos N, Reis C, Caffrey T, Hollingsworth M, et al. Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells. World J Gastroenterol. 2008;14:1411-4 pubmed
    To evaluate the influence of MUC1 mucin variable number of tandem repeats (VNTR) variability on H pylori adhesion to gastric cells...
  58. Zhao Q, Guo X, Nash G, Stone P, Hilkens J, Rhodes J, et al. Circulating galectin-3 promotes metastasis by modifying MUC1 localization on cancer cell surface. Cancer Res. 2009;69:6799-806 pubmed publisher
    ..These effects of galectin-3 are shown to be a consequence of its interaction with cancer-associated MUC1, which breaks the "protective shield" of the cell-surface MUC1 by causing MUC1 polarization, leading to ..
  59. Ye Q, Yan Z, Liao X, Li Y, Yang J, Sun J, et al. MUC1 induces metastasis in esophageal squamous cell carcinoma by upregulating matrix metalloproteinase 13. Lab Invest. 2011;91:778-87 pubmed publisher
    ..Given the associations of MUC1 with ESCC and tumor metastasis, we explored a potential role of MUC1 in ESCC metastasis...
  60. Behrens M, Grandgenett P, Bailey J, Singh P, Yi C, Yu F, et al. The reactive tumor microenvironment: MUC1 signaling directly reprograms transcription of CTGF. Oncogene. 2010;29:5667-77 pubmed publisher
    The MUC1 cytoplasmic tail (MUC1.CT) conducts signals from spatial and extracellular cues (growth factor and cytokine stimulation) to evoke a reprogramming of the cellular transcriptional profile. Specific phosphorylated forms of the MUC1...
  61. Agata N, Ahmad R, Kawano T, Raina D, Kharbanda S, Kufe D. MUC1 oncoprotein blocks death receptor-mediated apoptosis by inhibiting recruitment of caspase-8. Cancer Res. 2008;68:6136-44 pubmed publisher
    ..The MUC1 oncoprotein is aberrantly overexpressed by diverse human malignancies and inhibits stress-induced apoptosis...
  62. Saeki N, Saito A, Choi I, Matsuo K, Ohnami S, Totsuka H, et al. A functional single nucleotide polymorphism in mucin 1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer. Gastroenterology. 2011;140:892-902 pubmed publisher
    ..A region of a strong linkage disequilibrium with the 2 SNPs contained mucin 1 (MUC1) and other 4 genes and SNPs significantly associated with DGC (rs2070803: P = 4...
  63. Van Elssen C, Frings P, Bot F, Van de Vijver K, Huls M, Meek B, et al. Expression of aberrantly glycosylated Mucin-1 in ovarian cancer. Histopathology. 2010;57:597-606 pubmed publisher
    b>Mucin 1 (MUC1) is an important tumour-associated antigen (TAA), both overexpressed and aberrantly glycosylated in adenocarcinomas...
  64. Saeki N, Sakamoto H, Yoshida T. Mucin 1 gene (MUC1) and gastric-cancer susceptibility. Int J Mol Sci. 2014;15:7958-73 pubmed publisher
    ..GWAS) on Japanese and Chinese populations identified chromosome 1q22 as a GC susceptibility locus which harbors mucin 1 gene (MUC1) encoding a cell membrane-bound mucin protein...
  65. Song H, Kim H, Kweon S, Choi J, Shim H, Cho S, et al. Common genetic variants at 1q22 and 10q23 and gastric cancer susceptibility in a Korean population. Tumour Biol. 2014;35:3133-7 pubmed publisher
    ..The aim of this study was to determine whether rs4072037A > G in MUC1 at 1q22 and rs2274223A > G in PLCE1 at 10q23 are associated with a risk of gastric cancer in a Korean population...
  66. Stroopinsky D, Rosenblatt J, Ito K, Mills H, Yin L, Rajabi H, et al. MUC1 is a potential target for the treatment of acute myeloid leukemia stem cells. Cancer Res. 2013;73:5569-79 pubmed publisher
    Acute myeloid leukemia (AML) is a malignancy of stem cells with an unlimited capacity for self-renewal. MUC1 is a secreted, oncogenic mucin that is expressed aberrantly in AML blasts, but its potential uses to target AML stem cells have ..
  67. Corrales R, Narayanan S, Fernandez I, Mayo A, Galarreta D, Fuentes Páez G, et al. Ocular mucin gene expression levels as biomarkers for the diagnosis of dry eye syndrome. Invest Ophthalmol Vis Sci. 2011;52:8363-9 pubmed publisher
    To evaluate mRNA levels of the ocular mucins MUC1, MUC2, MUC4, MUC5AC, and MUC7 in conjunctival impression cytology samples from patients with moderate to severe dry eye syndrome (DES) compared with a population of healthy subjects; and ..
  68. Oudard S, Rixe O, Beuselinck B, Linassier C, Banu E, Machiels J, et al. A phase II study of the cancer vaccine TG4010 alone and in combination with cytokines in patients with metastatic renal clear-cell carcinoma: clinical and immunological findings. Cancer Immunol Immunother. 2011;60:261-71 pubmed publisher
    b>MUC1 over-expression in renal clear-cell carcinoma (RCC) is associated with poor prognosis...
  69. Abnet C, Freedman N, Hu N, Wang Z, Yu K, Shu X, et al. A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. Nat Genet. 2010;42:764-7 pubmed publisher
    ..19 x 10(-15); OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China. ..
  70. Ohshimo S, Bonella F, Grammann N, Starke K, Cui A, Bauer P, et al. Serum KL-6 as a novel disease marker in adolescent and adult cystic fibrosis. Sarcoidosis Vasc Diffuse Lung Dis. 2009;26:47-53 pubmed
    ..Serum levels of KL-6, high molecular weight human MUC1 mucin, are increased in the majority of patients with various interstitial lung disorders...
  71. Kufe D. Functional targeting of the MUC1 oncogene in human cancers. Cancer Biol Ther. 2009;8:1197-203 pubmed
  72. Kruit A, Tilanus Linthorst M, Boonstra J, van Schaik R, Grutters J, van den Bosch J, et al. MUC1 568 A/G genotype-dependent cancer antigen 15-3 levels in breast cancer patients. Clin Biochem. 2009;42:662-5 pubmed publisher
    CA 15-3 is a widely used tumor marker for breast cancer. We have investigated whether the MUC1 568 A/G polymorphism can influence CA 15-3 levels in healthy women and patients with breast tumors...
  73. Tinder T, Subramani D, Basu G, Bradley J, Schettini J, Million A, et al. MUC1 enhances tumor progression and contributes toward immunosuppression in a mouse model of spontaneous pancreatic adenocarcinoma. J Immunol. 2008;181:3116-25 pubmed
    b>MUC1, a membrane tethered mucin glycoprotein, is overexpressed and aberrantly glycosylated in >80% of human ductal pancreatic adenocarcinoma...
  74. Liu X, Yi C, Wen Y, Radhakrishnan P, Tremayne J, Dao T, et al. Interactions between MUC1 and p120 catenin regulate dynamic features of cell adhesion, motility, and metastasis. Cancer Res. 2014;74:1609-20 pubmed publisher
    The mechanisms by which MUC1 and p120 catenin contribute to progression of cancers from early transformation to metastasis are poorly understood...
  75. Fessler S, Wotkowicz M, Mahanta S, Bamdad C. MUC1* is a determinant of trastuzumab (Herceptin) resistance in breast cancer cells. Breast Cancer Res Treat. 2009;118:113-24 pubmed publisher
    ..was induced to acquire trastuzumab resistance showed a dramatic increase in the amount of the cleaved form of the MUC1 protein, called MUC1*...
  76. Yamada N, Nishida Y, Tsutsumida H, Hamada T, Goto M, Higashi M, et al. MUC1 expression is regulated by DNA methylation and histone H3 lysine 9 modification in cancer cells. Cancer Res. 2008;68:2708-16 pubmed publisher
    b>MUC1 is a transmembrane mucin that is highly expressed in various cancers and correlates with malignant potential...