mu opioid receptor


Gene Symbol: mu opioid receptor
Description: opioid receptor mu 1
Alias: LMOR, M-OR-1, MOP, MOR, MOR1, OPRM, mu-type opioid receptor, mu opiate receptor, mu opioid receptor hMOR-1a
Species: human
Products:     mu opioid receptor

Top Publications

  1. van den Wildenberg E, Wiers R, Dessers J, Janssen R, Lambrichs E, Smeets H, et al. A functional polymorphism of the mu-opioid receptor gene (OPRM1) influences cue-induced craving for alcohol in male heavy drinkers. Alcohol Clin Exp Res. 2007;31:1-10 pubmed
    ..The G allele might also predispose to drug use in general. ..
  2. Zhang H, Luo X, Kranzler H, Lappalainen J, Yang B, Krupitsky E, et al. Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence. Hum Mol Genet. 2006;15:807-19 pubmed
    ..These findings suggest that OPRM1 intronic variants play a role in susceptibility to AD and DD in populations of European ancestry. ..
  3. Shabalina S, Zaykin D, Gris P, Ogurtsov A, Gauthier J, Shibata K, et al. Expansion of the human mu-opioid receptor gene architecture: novel functional variants. Hum Mol Genet. 2009;18:1037-51 pubmed publisher
    ..conserved internal ribosome entry site (IRES) in the 5'-UTR of a novel exon 13-containing OPRM1 isoforms (MOR-1K) and affects both mRNA levels and translation efficiency of these variants...
  4. Ray L, Bujarski S, MacKillop J, Courtney K, Monti P, Miotto K. Subjective response to alcohol among alcohol-dependent individuals: effects of the ?-opioid receptor (OPRM1) gene and alcoholism severity. Alcohol Clin Exp Res. 2013;37 Suppl 1:E116-24 pubmed publisher
    ..A secondary aim of this study is to examine alcoholism severity as a predictor of subjective responses to alcohol...
  5. Hernandez Avila C, Wand G, Luo X, Gelernter J, Kranzler H. Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (OPRM1). Am J Med Genet B Neuropsychiatr Genet. 2003;118B:60-5 pubmed
    ..Given evidence of its pharmacological significance, the clinical relevance of this polymorphism warrants further investigation. ..
  6. Jin J, Kittanakom S, Wong V, Reyes B, Van Bockstaele E, Stagljar I, et al. Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence. BMC Neurosci. 2010;11:33 pubmed publisher
    ..The analgesic and addictive properties of opioid agonist drugs are mediated primarily via the mu-opioid receptor (MOR)...
  7. Hislop J, Henry A, von Zastrow M. Ubiquitination in the first cytoplasmic loop of ?-opioid receptors reveals a hierarchical mechanism of lysosomal down-regulation. J Biol Chem. 2011;286:40193-204 pubmed publisher contribute to homeostatic regulation of cellular opioid responsiveness, but mechanisms that mediate and control MOR down-regulation have not been defined...
  8. Luo X, Kranzler H, Zhao H, Gelernter J. Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans. Am J Med Genet B Neuropsychiatr Genet. 2003;120B:97-108 pubmed
    ..These findings suggest that OPRM1 may play a role in the pathophysiology of substance dependence and this role is population- and diagnosis-specific. ..
  9. Choi H, Kim C, Hwang C, Song K, Wang W, Qiu Y, et al. The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor. Biochem Biophys Res Commun. 2006;343:1132-40 pubmed
    ..actions of morphine and morphine-like drugs, such as heroin, mediate primarily through the mu-opioid receptor (MOR). It has been proposed that the functional diversity of MOR may be related to alternative splicing of the MOR gene...

More Information

Publications115 found, 100 shown here

  1. Ray R, Jepson C, Wileyto E, Dahl J, Patterson F, Rukstalis M, et al. Genetic variation in mu-opioid-receptor-interacting proteins and smoking cessation in a nicotine replacement therapy trial. Nicotine Tob Res. 2007;9:1237-41 pubmed
  2. Olsen M, Jacobsen L, Schistad E, Pedersen L, Rygh L, Røe C, et al. Pain intensity the first year after lumbar disc herniation is associated with the A118G polymorphism in the opioid receptor mu 1 gene: evidence of a sex and genotype interaction. J Neurosci. 2012;32:9831-4 pubmed publisher
    ..The present data suggest that OPRM1 G allele increases the pain intensity in women, but has a protective effect in men the first year after disc herniation. ..
  3. Schinka J, Town T, Abdullah L, Crawford F, Ordorica P, Francis E, et al. A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances. Mol Psychiatry. 2002;7:224-8 pubmed
    ..The contribution of the gene to risk for substance dependence is small, and is detected most easily in studies that use control samples that are screened for all forms of substance dependence. ..
  4. Shi J, Hui L, Xu Y, Wang F, Huang W, Hu G. Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin. Hum Mutat. 2002;19:459-60 pubmed
    ..Thus our study further highlights the importance of studing the various regions of the mu opioid receptor gene, coding as well as non-coding, for genetic markers that may be linked to, or directly contribute to ..
  5. Pang G, Wang J, Wang Z, Goh C, Lee C. The G allele of SNP E1/A118G at the mu-opioid receptor gene locus shows genomic evidence of recent positive selection. Pharmacogenomics. 2009;10:1101-9 pubmed publisher
    Opioid drug response and pain perception differs greatly amongst different individuals. The micro-opioid receptor (MOR) is the main receptor target for important opioid analgesics...
  6. Hoehe M, Kopke K, Wendel B, Rohde K, Flachmeier C, Kidd K, et al. Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence. Hum Mol Genet. 2000;9:2895-908 pubmed
    ..Using the human mu opioid receptor gene (OPRM1) as a model system, we have combined these approaches to test a potential role of OPRM1 in ..
  7. Fukuda K, Hayashida M, Ide S, Saita N, Kokita Y, Kasai S, et al. Association between OPRM1 gene polymorphisms and fentanyl sensitivity in patients undergoing painful cosmetic surgery. Pain. 2009;147:194-201 pubmed publisher
  8. Gelernter J, Gueorguieva R, Kranzler H, Zhang H, Cramer J, Rosenheck R, et al. Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study. Alcohol Clin Exp Res. 2007;31:555-63 pubmed
    ..A previous report suggested that a functional variant at the genetic locus encoding the mu opioid receptor (Asn40Asp) is such a marker, in short-term (3-month) treatment with the opioid-blocking drug naltrexone (NTX)..
  9. Ray L, Hutchison K. Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: a double-blind placebo-controlled study. Arch Gen Psychiatry. 2007;64:1069-77 pubmed
    ..This study advances the knowledge of mechanisms of action of naltrexone and genetic moderators of response to this pharmacotherapy. ..
  10. Romberg R, Olofsen E, Bijl H, Taschner P, Teppema L, Sarton E, et al. Polymorphism of mu-opioid receptor gene (OPRM1:c.118A>G) does not protect against opioid-induced respiratory depression despite reduced analgesic response. Anesthesiology. 2005;102:522-30 pubmed
    ..In OPRM1:c.118AA homozygotes, the potency parameters differed by a factor of 2 for analgesic versus respiratory effect. In this respect, M6G differs favorably from morphine. ..
  11. Nielsen D, Ji F, Yuferov V, Ho A, Chen A, Levran O, et al. Genotype patterns that contribute to increased risk for or protection from developing heroin addiction. Mol Psychiatry. 2008;13:417-28 pubmed publisher
    ..Evidence was found for involvement of five genes in heroin addiction, the genes coding for the mu opioid receptor, the metabotropic receptors mGluR6 and mGluR8, nuclear receptor NR4A2 and cryptochrome 1 (photolyase-like)...
  12. Sery O, Prikryl R, Castulík L, St astný F. A118G polymorphism of OPRM1 gene is associated with schizophrenia. J Mol Neurosci. 2010;41:219-22 pubmed publisher
    ..The neuronal myelination seems to be one of the important factors in the pathogenesis of schizophrenia. ..
  13. Uhl G, Sora I, Wang Z. The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses. Proc Natl Acad Sci U S A. 1999;96:7752-5 pubmed
    There are differences between human individuals and between mouse strains in levels of mu opiate receptor (muOR) expression, responses to painful stimuli, and responses to opiate drugs...
  14. Chong R, Oswald L, Yang X, Uhart M, Lin P, Wand G. The mu-opioid receptor polymorphism A118G predicts cortisol responses to naloxone and stress. Neuropsychopharmacology. 2006;31:204-11 pubmed
    A polymorphism in the mu-opioid receptor (MOR) (A118G) has been shown to increase beta-endorphin binding affinity, theoretically placing greater inhibitory tone on hypothalamic corticotropin-releasing hormone (CRH) neurons...
  15. Arias A, Feinn R, Kranzler H. Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis. Drug Alcohol Depend. 2006;83:262-8 pubmed
    ..Additional research is needed to determine whether these findings reflect no role for OPRM1 in determining risk for SD or whether another polymorphism in the gene influences receptor function and risk for SD. ..
  16. Ide S, Kobayashi H, Ujike H, Ozaki N, Sekine Y, Inada T, et al. Linkage disequilibrium and association with methamphetamine dependence/psychosis of mu-opioid receptor gene polymorphisms. Pharmacogenomics J. 2006;6:179-88 pubmed
    ..There was also a significant association between IVS2+G691C and patients with transient psychosis. These results suggest that the OPRM1 gene variations may be a factor in development and prognosis of MAP psychosis. ..
  17. Landau R, Kern C, Columb M, Smiley R, Blouin J. Genetic variability of the mu-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring women. Pain. 2008;139:5-14 pubmed publisher
    ..These findings for intrathecal fentanyl pharmacogenetics may have implications for patients receiving opioids in other settings. ..
  18. Glatt S, Bousman C, Wang R, Murthy K, Rana B, Lasky Su J, et al. Evaluation of OPRM1 variants in heroin dependence by family-based association testing and meta-analysis. Drug Alcohol Depend. 2007;90:159-65 pubmed
  19. Bergen A, Kokoszka J, Peterson R, Long J, Virkkunen M, Linnoila M, et al. Mu opioid receptor gene variants: lack of association with alcohol dependence. Mol Psychiatry. 1997;2:490-4 pubmed
    The mu opioid receptor is implicated in the reward, tolerance and withdrawal effects of alcohol and other drugs of abuse...
  20. Pan Y, Xu J, Mahurter L, Xu M, Gilbert A, Pasternak G. Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X. Biochem Biophys Res Commun. 2003;301:1057-61 pubmed
    The mouse gene encoding the mu opioid receptor, Oprm, undergoes extensive alternatively splicing, with 14 variants having been identified. However, only one variant of human mu opioid receptor gene (Oprm), MOR-1A, has been described...
  21. Zhang W, Yuan J, Kan Q, Zhang L, Chang Y, Wang Z. Study of the OPRM1 A118G genetic polymorphism associated with postoperative nausea and vomiting induced by fentanyl intravenous analgesia. Minerva Anestesiol. 2011;77:33-9 pubmed
    ..OPRM1 A118G has no effect on the individual variation of postoperative nausea and vomiting, the side effects of fentanyl analgesia, in Chinese women undergoing gynecologic surgery. ..
  22. Pfeiffer M, Kirscht S, Stumm R, Koch T, Wu D, Laugsch M, et al. Heterodimerization of substance P and mu-opioid receptors regulates receptor trafficking and resensitization. J Biol Chem. 2003;278:51630-7 pubmed
    The micro-opioid receptor (MOR1) and the substance P receptor (NK1) coexist and functionally interact in nociceptive brain regions; however, a molecular basis for this interaction has not been established...
  23. Janicki P, Schuler G, Francis D, Bohr A, Gordin V, Jarzembowski T, et al. A genetic association study of the functional A118G polymorphism of the human mu-opioid receptor gene in patients with acute and chronic pain. Anesth Analg. 2006;103:1011-7 pubmed
    ..observational study we explored whether A118G single nucleotide polymorphism in the human mu-opioid receptor (MOR) gene could explain the inter-individual differences in opioid analgesic requirements in patients with acute ..
  24. Davis C, Levitan R, Reid C, Carter J, Kaplan A, Patte K, et al. Dopamine for "wanting" and opioids for "liking": a comparison of obese adults with and without binge eating. Obesity (Silver Spring). 2009;17:1220-5 pubmed publisher
  25. Fukuda K, Hayashida M, Ikeda K. [Postoperative pain management following orthognathic surgery in consideration of individual differences--is the antinociceptive effect of fentanyl related to the genotype involving nucleotide at OPRM1?]. Masui. 2009;58:1102-8 pubmed
    ..In the future, identifying SNPs might give us information to modulate the analgesic dosage of opioid individually for better pain control...
  26. Wang Y, Huang P, Ung A, Blendy J, Liu Chen L. Reduced expression of the μ opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G. Neuroscience. 2012;205:178-84 pubmed publisher
    OPRM1 A118G is a common single nucleotide polymorphism (SNP) in the coding region of the human mu opioid receptor (MOPR) gene OPRM1...
  27. Klepstad P, Rakvåg T, Kaasa S, Holthe M, Dale O, Borchgrevink P, et al. The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease. Acta Anaesthesiol Scand. 2004;48:1232-9 pubmed
    ..Thus, genetic variation at the gene encoding the mu-opioid receptor contributes to variability in patients' responses to morphine. ..
  28. Bart G, LaForge K, Borg L, Lilly C, Ho A, Kreek M. Altered levels of basal cortisol in healthy subjects with a 118G allele in exon 1 of the Mu opioid receptor gene. Neuropsychopharmacology. 2006;31:2313-7 pubmed
    The mu opioid receptor is centrally involved in the development of the addictive diseases. It also modulates the stress responsive hypothalamic-pituitary-adrenal axis...
  29. Zhang D, Shao C, Shao M, Yan P, Wang Y, Liu Y, et al. Effect of mu-opioid receptor gene polymorphisms on heroin-induced subjective responses in a Chinese population. Biol Psychiatry. 2007;61:1244-51 pubmed
    ..0, p <or= .0001). Self-reported positive responses on first use of heroin were found to be associated with OPRM1. The findings suggest that heroin-induced positive responses are likely associated with more heroin consumption. ..
  30. Bart G, Kreek M, Ott J, LaForge K, Proudnikov D, Pollak L, et al. Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden. Neuropsychopharmacology. 2005;30:417-22 pubmed
    The mu-opioid receptor (MOR), through its effects on reward and stress-responsivity, modulates alcohol intake in both animal and human laboratory studies...
  31. Gris P, Gauthier J, Cheng P, Gibson D, Gris D, Laur O, et al. A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism. Mol Pain. 2010;6:33 pubmed publisher
    ..In contrast to stimulation of MOR1, stimulation of MOR1K leads to increased Ca2+ levels as well as increased nitric oxide (NO) release...
  32. Cadet P, Mantione K, Stefano G. Molecular identification and functional expression of mu 3, a novel alternatively spliced variant of the human mu opiate receptor gene. J Immunol. 2003;170:5118-23 pubmed
    Studies from our laboratory have revealed a novel mu opiate receptor, mu 3, which is expressed in both vascular tissues and leukocytes. The mu 3 receptor is selective for opiate alkaloids and is insensitive to opioid peptides...
  33. Huang C, Liu H, Su N, Hsu Y, Yang C, Chen C, et al. Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females*. Anaesthesia. 2008;63:1288-95 pubmed publisher
    ..These data suggest an association between the IVS2+31G>A SNP of the OPRM1 gene and pressure pain sensitivity in healthy adult females. ..
  34. Kim S, Kim C, Choi S, Jae Y, Lee H, Son B, et al. A micro opioid receptor gene polymorphism (A118G) and naltrexone treatment response in adherent Korean alcohol-dependent patients. Psychopharmacology (Berl). 2009;201:611-8 pubmed publisher
    Previous studies have demonstrated an association between genetic polymorphisms of the mu opioid receptor gene (OPRM1) and response to naltrexone treatment...
  35. Bare L, Mansson E, Yang D. Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain. FEBS Lett. 1994;354:213-6 pubmed
    A partial mu opioid receptor gene was isolated from a human genomic library using a mouse delta opioid receptor cDNA as a probe...
  36. Corley R, Zeiger J, Crowley T, Ehringer M, Hewitt J, Hopfer C, et al. Association of candidate genes with antisocial drug dependence in adolescents. Drug Alcohol Depend. 2008;96:90-8 pubmed publisher
    ..The custom-designed SNP chip served as an effective and flexible platform for rapid interrogation of a large number of plausible candidate genes. ..
  37. Levran O, Londono D, O Hara K, Nielsen D, Peles E, Rotrosen J, et al. Genetic susceptibility to heroin addiction: a candidate gene association study. Genes Brain Behav. 2008;7:720-9 pubmed publisher
    ..0005). None of these associations remained significant after adjustment for multiple testing. This study suggests the involvement of several genes and variants in heroin addiction, which is worthy of future study. ..
  38. Pratt W, Davidson D. Role of the HPA axis and the A118G polymorphism of the mu-opioid receptor in stress-induced drinking behavior. Alcohol Alcohol. 2009;44:358-65 pubmed publisher
    ..The Asp40 variant of the mu-opioid receptor may be associated with this HPA axis hyporeactivity although the small sample size used in the present study did not permit adequate evaluation of this association. ..
  39. Ramchandani V, Umhau J, Pavón F, Ruiz Velasco V, Margas W, Sun H, et al. A genetic determinant of the striatal dopamine response to alcohol in men. Mol Psychiatry. 2011;16:809-17 pubmed publisher
    ..OPRM1 A118G variation is a genetic determinant of dopamine responses to alcohol, a mechanism by which it likely modulates alcohol reward. ..
  40. Chen D, Liu L, Xiao Y, Peng Y, Yang C, Wang Z. Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians. Drug Alcohol Depend. 2012;123:1-6 pubmed publisher
    ..22-2.02), but not in Caucasians (GA vs. AA: OR, 1.05; 95% CI, 0.75-1.49; GA+GG vs. AA: OR, 1.11; 95% CI, 0.79-1.55). The OPRM1 A118G polymorphism may contribute to the susceptibility of alcohol dependence in Asians but not in Caucasians. ..
  41. Tan E, Lim E, Teo Y, Lim Y, Law H, Sia A. Ethnicity and OPRM variant independently predict pain perception and patient-controlled analgesia usage for post-operative pain. Mol Pain. 2009;5:32 pubmed publisher
    ..mediate the analgesic effects of opioid compounds in the central nervous system, we examined the influence of two OPRM polymorphisms on acute post-operative pain and morphine usage in women undergoing elective caesarean delivery...
  42. Zhang W, Chang Y, Kan Q, Zhang L, Lu H, Chu Q, et al. Association of human micro-opioid receptor gene polymorphism A118G with fentanyl analgesia consumption in Chinese gynaecological patients. Anaesthesia. 2010;65:130-5 pubmed publisher
    ..Fentanyl consumption increased in accordance with the number of 118G alleles. We conclude that OPRM1 gene analysis may help predict individual opioid sensitivity and so optimise postoperative pain control. ..
  43. Bart G, Heilig M, LaForge K, Pollak L, Leal S, Ott J, et al. Substantial attributable risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central Sweden. Mol Psychiatry. 2004;9:547-9 pubmed
  44. Kranzler H, Armeli S, Covault J, Tennen H. Variation in OPRM1 moderates the effect of desire to drink on subsequent drinking and its attenuation by naltrexone treatment. Addict Biol. 2013;18:193-201 pubmed publisher
  45. Troisi A, Frazzetto G, Carola V, Di Lorenzo G, Coviello M, D Amato F, et al. Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients. Soc Neurosci. 2011;6:88-97 pubmed publisher
    ..The results reported here are in agreement with the brain opioid hypothesis of social attachment and the established role of opioid transmission in mediating affiliative behavior. ..
  46. Ray R, Ruparel K, Newberg A, Wileyto E, Loughead J, Divgi C, et al. Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers. Proc Natl Acad Sci U S A. 2011;108:9268-73 pubmed publisher
    Evidence points to the endogenous opioid system, and the mu-opioid receptor (MOR) in particular, in mediating the rewarding effects of drugs of abuse, including nicotine...
  47. Kapur S, Sharad S, Singh R, Gupta A. A118g polymorphism in mu opioid receptor gene (oprm1): association with opiate addiction in subjects of Indian origin. J Integr Neurosci. 2007;6:511-22 pubmed
    ..The OPRM1 gene, which encodes for mu opioid receptor, contains several single nucleotide polymorphisms (SNPs) in exon I...
  48. Lotsch J, Zimmermann M, Darimont J, Marx C, Dudziak R, Skarke C, et al. Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity?. Anesthesiology. 2002;97:814-9 pubmed
  49. Lerman C, Wileyto E, Patterson F, Rukstalis M, Audrain McGovern J, Restine S, et al. The functional mu opioid receptor (OPRM1) Asn40Asp variant predicts short-term response to nicotine replacement therapy in a clinical trial. Pharmacogenomics J. 2004;4:184-92 pubmed
    ..Smokers who carry the OPRM1 Asp40 variant are likely to have a favorable response to TN and may benefit from extended therapy with the 21 mg dose. ..
  50. Garriock H, Tanowitz M, Kraft J, Dang V, Peters E, Jenkins G, et al. Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder. Am J Psychiatry. 2010;167:565-73 pubmed publisher
  51. Hernandez Avila C, Covault J, Wand G, Zhang H, Gelernter J, Kranzler H. Population-specific effects of the Asn40Asp polymorphism at the mu-opioid receptor gene (OPRM1) on HPA-axis activation. Pharmacogenet Genomics. 2007;17:1031-8 pubmed
    ..Further research to understand the basis for the observed association is warranted. ..
  52. Ide S, Kobayashi H, Tanaka K, Ujike H, Sekine Y, Ozaki N, et al. Gene polymorphisms of the mu opioid receptor in methamphetamine abusers. Ann N Y Acad Sci. 2004;1025:316-24 pubmed
    ..We have investigated associations of the mu-opioid receptor gene (OPRM) variations with methamphetamine (MAP) dependence/psychosis...
  53. Ray L, Hutchison K. A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans. Alcohol Clin Exp Res. 2004;28:1789-95 pubmed
    ..A medication that reduces feelings of euphoria after alcohol consumption may be more successful among individuals with a genetic predisposition to greater feelings of euphoria after consuming alcohol. ..
  54. Mathew B, Lennon F, Siegler J, Mirzapoiazova T, Mambetsariev N, Sammani S, et al. The novel role of the mu opioid receptor in lung cancer progression: a laboratory investigation. Anesth Analg. 2011;112:558-67 pubmed publisher
    ..In this study, we identify a possible mechanism for these epidemiologic findings on the basis of ? opioid receptor (MOR) regulation of Lewis lung carcinoma (LLC) tumorigenicity in cell and animal models...
  55. Chou W, Yang L, Lu H, Ko J, Wang C, Lin S, et al. Association of mu-opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty. Acta Anaesthesiol Scand. 2006;50:787-92 pubmed
    ..The genotype may thus influence the post-operative response to pain and cause differences in the amounts of analgesic consumed by patients after total knee arthroplasty. ..
  56. Onoprishvili I, Andria M, Kramer H, Ancevska Taneva N, Hiller J, Simon E. Interaction between the mu opioid receptor and filamin A is involved in receptor regulation and trafficking. Mol Pharmacol. 2003;64:1092-100 pubmed
    The carboxyl tail of the human mu opioid receptor was shown to bind the carboxyl terminal region of human filamin A, a protein known to couple membrane proteins to actin...
  57. Kim S, Kim J, Song J, Park S, Lee H, Chung J. Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients. Alcohol. 2004;34:115-20 pubmed
    ..The polymorphisms of ADH2, ALDH2, and CYP2E1 were significantly different in Korean patients with alcoholism and Korean control subjects without alcoholism, but ADH3 and OPRM1 did not differ between the two groups. ..
  58. Mague S, Blendy J. OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models. Drug Alcohol Depend. 2010;108:172-82 pubmed publisher
    ..Evaluation of models that incorporate known human genetic variants into a tractable system, like the mouse, will facilitate the understanding of discrete contributions of SNPs to human disease. ..
  59. Zhang Y, Wang D, Johnson A, Papp A, Sadee W. Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. J Biol Chem. 2005;280:32618-24 pubmed
    As a primary target for opioid drugs and peptides, the mu opioid receptor (OPRM1) plays a key role in pain perception and addiction...
  60. van der Zwaluw C, van den Wildenberg E, Wiers R, Franke B, Buitelaar J, Scholte R, et al. Polymorphisms in the mu-opioid receptor gene (OPRM1) and the implications for alcohol dependence in humans. Pharmacogenomics. 2007;8:1427-36 pubmed
    ..Factors that complicate genetic research on alcohol dependence, such as gene-environment interaction, and genetic and clinical heterogeneity, are discussed. ..
  61. Ono T, Kaneda T, Muto A, Yoshida T. Positive transcriptional regulation of the human micro opioid receptor gene by poly(ADP-ribose) polymerase-1 and increase of its DNA binding affinity based on polymorphism of G-172 -> T. J Biol Chem. 2009;284:20175-83 pubmed publisher
    Micro opioid receptor (MOR) agonists such as morphine are applied widely in clinical practice as pain therapy...
  62. Wang J, Johnson P, Persico A, Hawkins A, Griffin C, Uhl G. Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. FEBS Lett. 1994;338:217-22 pubmed
    A human mu opiate receptor cDNA has been identified from a cerebral cortical cDNA library using sequences from the rat mu opiate receptor cDNA. The human mu opiate receptor (h mu OR1) shares 95% amino acid identity with the rat sequence...
  63. Smith R, Doyle G, Han A, Crowley J, Oslin D, Patkar A, et al. Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence. Am J Med Genet B Neuropsychiatr Genet. 2005;133B:105-9 pubmed
    The mu-opioid receptor (MOR) mediates reward and dependence associated with opioids and other commonly abused substances. Variability in the MOR gene, OPRM1, may influence risk for opioid dependence...
  64. Luo X, Zuo L, Kranzler H, Zhang H, Wang S, Gelernter J. Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1028-39 pubmed publisher
    ..Further, the three OPR genes have significant interaction effects on personality traits. This work provides additional evidence that personality traits and SD have a partially overlapping genetic basis. ..
  65. Bayerer B, Stamer U, Hoeft A, Stuber F. Genomic variations and transcriptional regulation of the human mu-opioid receptor gene. Eur J Pain. 2007;11:421-7 pubmed
    The mu-opioid receptor (MOR1) is a target of endogenous and exogenous opioids and plays a pivotal role for anesthesia and analgesia...
  66. Lotsch J, Stuck B, Hummel T. The human mu-opioid receptor gene polymorphism 118A > G decreases cortical activation in response to specific nociceptive stimulation. Behav Neurosci. 2006;120:1218-24 pubmed
    ..6% of the cases as carriers or noncarriers of the allele. The OPRM1 118A > G polymorphism specifically modulates nociceptive but not nonnociceptive cortical activation. ..
  67. Huang P, Chen C, Mague S, Blendy J, Liu Chen L. A common single nucleotide polymorphism A118G of the ? opioid receptor alters its N-glycosylation and protein stability. Biochem J. 2012;441:379-86 pubmed publisher
    ..Pulse-chase studies revealed that the half-life of the mature form of 118G/Asp40-hMOPR (~12 h) was shorter than that of 118A/Asn40-hMOPR (~28 h). Thus the A118G SNP reduces MOPR N-glycosylation and protein stability. ..
  68. Chamorro A, Marcos M, Mirón Canelo J, Pastor I, Gonzalez Sarmiento R, Laso F. Association of µ-opioid receptor (OPRM1) gene polymorphism with response to naltrexone in alcohol dependence: a systematic review and meta-analysis. Addict Biol. 2012;17:505-12 pubmed publisher
    ..This genetic marker may therefore identify a subgroup of individuals more likely to respond to this treatment. ..
  69. Wand G, McCaul M, Yang X, Reynolds J, Gotjen D, Lee S, et al. The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade. Neuropsychopharmacology. 2002;26:106-14 pubmed
    ..It is plausible that persons expressing the mu-opioid receptor variant have altered HPA axis dynamics and altered responses to other physiological processes regulated through activation of the mu-opioid receptor. ..
  70. Fillingim R, Kaplan L, Staud R, Ness T, Glover T, Campbell C, et al. The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. J Pain. 2005;6:159-67 pubmed
    ..The results indicate that the rare allele is associated with higher pressure pain thresholds. These results support previous contentions that OPRM1 may be a pain-relevant gene; however, replication of these findings is needed. ..
  71. Anton R, Oroszi G, O MALLEY S, Couper D, Swift R, Pettinati H, et al. An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry. 2008;65:135-44 pubmed publisher
    ..This relationship might be obscured, however, by other efficacious treatments. OPRM1 genotyping in alcoholic individuals might be useful to assist in selecting treatment options. Identifier: NCT00006206. ..
  72. Crowley J, Oslin D, Patkar A, Gottheil E, Demaria P, O Brien C, et al. A genetic association study of the mu opioid receptor and severe opioid dependence. Psychiatr Genet. 2003;13:169-73 pubmed
    ..1994; Alexander et al., 1996), which harbors the mu opioid receptor gene (Mor1) (Kozak et al., 1994)...
  73. Way B, Taylor S, Eisenberger N. Variation in the mu-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection. Proc Natl Acad Sci U S A. 2009;106:15079-84 pubmed publisher
    ..Taken together, these data suggest that the A118G polymorphism specifically, and the mu-opioid receptor more generally, are involved in social pain in addition to physical pain. ..
  74. Talbot J, Skifter D, Bianchi E, Monaghan D, Toews M, Murrin L. Regulation of mu opioid receptor internalization by the scaffold protein RanBPM. Neurosci Lett. 2009;466:154-8 pubmed publisher
    Mu opioid receptors (MOP) are transducers of the pharmacological effects of many opioid drugs, including analgesia and tolerance/dependence...
  75. Coulbault L, Beaussier M, Verstuyft C, Weickmans H, Dubert L, Tregouet D, et al. Environmental and genetic factors associated with morphine response in the postoperative period. Clin Pharmacol Ther. 2006;79:316-24 pubmed
    ..Age and prior use of psychotropic agents are associated with postoperative morphine dose requirements. Whether ABCB1 polymorphisms might predict morphine side effects remains to be determined. ..
  76. Kim S, Kim C, Kang D, Kim Y, Byun W, Kim S, et al. Association of functional opioid receptor genotypes with alcohol dependence in Koreans. Alcohol Clin Exp Res. 2004;28:986-90 pubmed
    ..These results suggest that having one or two copies of the A118G allele is common among Koreans and may be an important genetic factor in the etiology of alcohol dependence and the frequency of alcohol consumption. ..
  77. Oroszi G, Anton R, O MALLEY S, Swift R, Pettinati H, Couper D, et al. OPRM1 Asn40Asp predicts response to naltrexone treatment: a haplotype-based approach. Alcohol Clin Exp Res. 2009;33:383-93 pubmed publisher
    ..A substantial contribution of any other OPRM1 genetic variant to interindividual variations in response to naltrexone treatment (at least in terms of good clinical outcome) is not supported by our findings. ..
  78. Pan L, Xu J, Yu R, Xu M, Pan Y, Pasternak G. Identification and characterization of six new alternatively spliced variants of the human mu opioid receptor gene, Oprm. Neuroscience. 2005;133:209-20 pubmed
    The mu opioid receptor plays an important role in mediating the actions of morphine and morphine-like drugs...
  79. Xu J, Xu M, Hurd Y, Pasternak G, Pan Y. Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene. J Neurochem. 2009;108:962-72 pubmed publisher
    Alternative splicing of the mu opioid receptor genes to create multiple mu receptor subtypes has been demonstrated in animals and humans...
  80. Reyes Gibby C, Shete S, Rakvåg T, Bhat S, Skorpen F, Bruera E, et al. Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene. Pain. 2007;130:25-30 pubmed
    ..Future studies are needed to further characterize the joint effects of multiple genes, along with demographic and clinical variables, in predicting opioid dose. ..
  81. Xuei X, Flury Wetherill L, Bierut L, Dick D, Nurnberger J, Foroud T, et al. The opioid system in alcohol and drug dependence: family-based association study. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:877-84 pubmed
  82. Sia A, Lim Y, Lim E, Goh R, Law H, Landau R, et al. A118G single nucleotide polymorphism of human mu-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia. Anesthesiology. 2008;109:520-6 pubmed publisher
    ..Genetic variation at position 118 of the mu-opioid receptor is associated with interindividual differences in pain scores, self-administered intravenous morphine, and the incidence of nausea postoperatively. ..
  83. Franke P, Wang T, Nöthen M, Knapp M, Neidt H, Albrecht S, et al. Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependence. Am J Med Genet. 2001;105:114-9 pubmed
    ..In addition, there was no significant association between the endophenotype of the individuals under study (e.g., comorbidity, severity of illness) and a particular genotype of OPRM1. ..
  84. Matsunaga M, Isowa T, Murakami H, Kasugai K, Yoneda M, Kaneko H, et al. Association of polymorphism in the human mu-opioid receptor OPRM1 gene with proinflammatory cytokine levels and health perception. Brain Behav Immun. 2009;23:931-5 pubmed publisher
    ..These results suggest that the sensitive endogenous opioid system in carriers of the G allele may suppress proinflammatory cytokine secretion from peripheral immune cells; consequently, it may influence the health perception. ..
  85. Oslin D, Berrettini W, Kranzler H, Pettinati H, Gelernter J, Volpicelli J, et al. A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients. Neuropsychopharmacology. 2003;28:1546-52 pubmed
    ..If replicated, these results would help to identify alcohol-dependent individuals who may be most likely to respond to treatment with naltrexone. ..
  86. Lennon F, Mirzapoiazova T, Mambetsariev B, Salgia R, Moss J, Singleton P. Overexpression of the ?-opioid receptor in human non-small cell lung cancer promotes Akt and mTOR activation, tumor growth, and metastasis. Anesthesiology. 2012;116:857-67 pubmed publisher
    ..Stable vector control and MOR1 overexpressing human bronchioloalveolar carcinoma cells were evaluated using immunoblot analysis, proliferation and ..
  87. Hayashida M, Nagashima M, Satoh Y, Katoh R, Tagami M, Ide S, et al. Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype. Pharmacogenomics. 2008;9:1605-16 pubmed publisher
    ..These results suggest that OPRM1 gene tag SNP genotypes and haplotypes can primarily contribute to prediction of postoperative analgesic requirements in individual patients undergoing major open abdominal surgery. ..
  88. Chou W, Wang C, Liu P, Liu C, Tseng C, Jawan B. Human opioid receptor A118G polymorphism affects intravenous patient-controlled analgesia morphine consumption after total abdominal hysterectomy. Anesthesiology. 2006;105:334-7 pubmed
    ..In the future, identifying single nucleotide polymorphisms of patients may provide information to modulate the analgesic dosage of opioid for better pain control. ..
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  90. Tan E, Chong S, Mahendran R, Tan C, Teo Y. Mu opioid receptor gene polymorphism and neuroleptic-induced tardive dyskinesia in patients with schizophrenia. Schizophr Res. 2003;65:61-3 pubmed
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    ..experimental situations, and several association studies have examined possible roles of opioid receptor mu (OPRM), delta (OPRD), and kappa (OPRK) genes in the development of alcohol dependence...
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