Gene Symbol: MTUS2
Description: microtubule associated scaffold protein 2
Alias: CAZIP, ICIS, KIAA0774, TIP150, microtubule-associated tumor suppressor candidate 2, +TIP of 150 kDa, cardiac zipper protein, microtubule associated tumor suppressor candidate 2, microtubule plus-end tracking protein TIP150, tracking protein of 150 kDa
Species: human
Products:     MTUS2

Top Publications

  1. Jiang K, Wang J, Liu J, Ward T, Wordeman L, Davidson A, et al. TIP150 interacts with and targets MCAK at the microtubule plus ends. EMBO Rep. 2009;10:857-65 pubmed publisher
    ..Here, we show that TIP150 is a new +TIP that binds to end-binding protein 1 (EB1) in vitro and co-localizes with EB1 at the MT plus ends in ..
  2. du Puy L, Beqqali A, Monshouwer Kloots J, Haagsman H, Roelen B, Passier R. CAZIP, a novel protein expressed in the developing heart and nervous system. Dev Dyn. 2009;238:2903-11 pubmed publisher
    ..Hence, we named this protein CAZIP (cardiac zipper protein). Later during embryonic development, Cazip was also expressed in parts of the nervous system...
  3. Xia P, Wang Z, Liu X, Wu B, Wang J, Ward T, et al. EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis. Proc Natl Acad Sci U S A. 2012;109:16564-9 pubmed publisher
    ..These results establish a previously uncharacterized regulatory mechanism governing localization of microtubule plus-end tracking proteins and thereby the plasticity and dynamics of cells. ..
  4. Cheng Z, Ke Y, Ding X, Wang F, Wang H, Wang W, et al. Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response. Oncogene. 2008;27:931-41 pubmed
    ..Thus, this study shed new light on the function and regulation of TIP60 activity in UV-irradiated DNA damage response. ..
  5. TreviƱo L, Shimasaki N, Yang W, Panetta J, Cheng C, Pei D, et al. Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. J Clin Oncol. 2009;27:5972-8 pubmed publisher
    ..4; P = .03 to .004). A genome-wide interrogation identified inherited variations in a plausible, yet heretofore low-priority candidate gene, SLCO1B1, as important determinants of methotrexate's pharmacokinetics and clinical effects. ..
  6. Rodrigues Ferreira S, Nahmias C. An ATIPical family of angiotensin II AT2 receptor-interacting proteins. Trends Endocrinol Metab. 2010;21:684-90 pubmed publisher
    ..Recent findings that ATIPs and ATIP-related proteins associate with microtubules suggest that they might constitute a novel family of multifunctional proteins regulating a wide range of physiopathological functions. ..
  7. Byrne E, Johnson J, McRae A, Nyholt D, Medland S, Gehrman P, et al. A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor. Sleep. 2012;35:967-75 pubmed publisher
    ..They will require replication in another sample. The results may have implications for understanding the biologic mechanisms underlying insomnia. ..
  8. Ward T, Wang M, Liu X, Wang Z, Xia P, Chu Y, et al. Regulation of a dynamic interaction between two microtubule-binding proteins, EB1 and TIP150, by the mitotic p300/CBP-associated factor (PCAF) orchestrates kinetochore microtubule plasticity and chromosome stability during mitosis. J Biol Chem. 2013;288:15771-85 pubmed publisher
    ..Here, we demonstrate that the plus-end tracking protein, TIP150, regulates dynamic kinetochore-microtubule attachments by promoting the stability of spindle microtubule plus-ends...
  9. Xia P, Zhou J, Song X, Wu B, Liu X, Li D, et al. Aurora A orchestrates entosis by regulating a dynamic MCAK-TIP150 interaction. J Mol Cell Biol. 2014;6:240-54 pubmed publisher
    ..Microtubule plus-end-tracking protein TIP150 facilitates the loading of MCAK onto the microtubule plus ends and orchestrates microtubule plus-end dynamics ..

More Information


  1. Adams G, Zhou J, Wang W, Wu H, Quan J, Liu Y, et al. The Microtubule Plus End Tracking Protein TIP150 Interacts with Cortactin to Steer Directional Cell Migration. J Biol Chem. 2016;291:20692-706 pubmed publisher
    ..How these interactions facilitate these dynamic processes is still being actively investigated. TIP150 is a newly characterized microtubule plus end tracking protein essential for mitosis and entosis (Ward, T...