MTNR1B

Summary

Gene Symbol: MTNR1B
Description: melatonin receptor 1B
Alias: FGQTL2, MEL-1B-R, MT2, melatonin receptor type 1B, mel1b receptor, melatonin receptor 1B variant b, melatonin receptor MEL1B
Species: human
Products:     MTNR1B

Top Publications

  1. Olsson L, Pettersen E, Ahlbom A, Carlsson S, Midthjell K, Grill V. No effect by the common gene variant rs10830963 of the melatonin receptor 1B on the association between sleep disturbances and type 2 diabetes: results from the Nord-Trøndelag Health Study. Diabetologia. 2011;54:1375-8 pubmed publisher
    Genetic variation in the melatonin receptor 1B (MTNR1B) is associated with type 2 diabetes. Melatonin contributes to the regulation of sleep, and sleep problems are a documented risk factor for type 2 diabetes...
  2. Mórocz M, Czibula A, Grózer Z, Szécsényi A, Almos P, Raskó I, et al. Association study of BMP4, IL6, Leptin, MMP3, and MTNR1B gene promoter polymorphisms and adolescent idiopathic scoliosis. Spine (Phila Pa 1976). 2011;36:E123-30 pubmed publisher
    ..protein 4 (BMP4), interleukin-6 (IL6), leptin, matrix metalloproteinase-3 (MMP3), melatonin 1B receptor (MTNR1B) genes in adolescent idiopathic scoliosis (AIS)...
  3. Staiger H, Machicao F, Schäfer S, Kirchhoff K, Kantartzis K, Guthoff M, et al. Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function. PLoS ONE. 2008;3:e3962 pubmed publisher
    Very recently, a novel type 2 diabetes risk gene, i.e., MTNR1B, was identified and reported to affect fasting glycemia...
  4. Lyssenko V, Nagorny C, Erdos M, Wierup N, Jonsson A, Spégel P, et al. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet. 2009;41:82-8 pubmed publisher
    Genome-wide association studies have shown that variation in MTNR1B (melatonin receptor 1B) is associated with insulin and glucose concentrations...
  5. Xia Q, Chen Z, Wang Y, Ma Y, Zhang F, Che W, et al. Association between the melatonin receptor 1B gene polymorphism on the risk of type 2 diabetes, impaired glucose regulation: a meta-analysis. PLoS ONE. 2012;7:e50107 pubmed publisher
    Melatonin receptor 1B (MTNR1B) belongs to the seven-transmembrane G protein-coupled receptor superfamily involved in insulin secretion, which has attracted considerable attention as a candidate gene for type 2 diabetes (T2D) since it was ..
  6. Kwak S, Kim S, Cho Y, Go M, Cho Y, Choi S, et al. A genome-wide association study of gestational diabetes mellitus in Korean women. Diabetes. 2012;61:531-41 pubmed publisher
    ..518; P=6.65×10(-16)). A variant near MTNR1B, rs10830962, was also significantly associated with the risk of GDM (1.454; P=2.49×10(-13))...
  7. Ayoub M, Levoye A, Delagrange P, Jockers R. Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers. Mol Pharmacol. 2004;66:312-21 pubmed
  8. Sparsø T, Bonnefond A, Andersson E, Bouatia Naji N, Holmkvist J, Wegner L, et al. G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans. Diabetes. 2009;58:1450-6 pubmed publisher
    Genome-wide association studies have identified several variants within the MTNR1B locus that are associated with fasting plasma glucose (FPG) and type 2 diabetes...
  9. Brzezinski A. Melatonin in humans. N Engl J Med. 1997;336:186-95 pubmed

More Information

Publications78

  1. Song J, Wang H, Ma J, Xu Z, Hinney A, Hebebrand J, et al. Association of the rs10830963 polymorphism in MTNR1B with fasting glucose levels in Chinese children and adolescents. Obes Facts. 2011;4:197-203 pubmed publisher
    ..The rs10830963 polymorphism in MTNR1B was genotyped in 2,030 Chinese children and adolescents of two independent studies...
  2. Hu C, Zhang R, Wang C, Yu W, Lu J, Ma X, et al. Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion. PLoS ONE. 2010;5:e11761 pubmed publisher
    Single nucleotide polymorphisms (SNPs) from GCK, GCKR, G6PC2 and MTNR1B were found to modulate the fasting glucose levels...
  3. Stancakova A, Kuulasmaa T, Paananen J, Jackson A, Bonnycastle L, Collins F, et al. Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men. Diabetes. 2009;58:2129-36 pubmed publisher
    ..HHEX, LOC387761, CDKN2B, IGF2BP2, CDKAL1, HNF1B, WFS1, JAZF1, CDC123, TSPAN8, THADA, ADAMTS9, NOTCH2, KCNQ1, and MTNR1B were performed. HNF1B rs757210 was excluded because of failure to achieve Hardy-Weinberg equilibrium...
  4. Rönn T, Wen J, Yang Z, Lu B, Du Y, Groop L, et al. A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals. Diabetologia. 2009;52:830-3 pubmed publisher
    Recently, three groups independently reported that variation in MTNR1B, the gene encoding melatonin receptor 1B, was associated with an increased risk of type 2 diabetes, increased fasting plasma glucose and impaired insulin secretion in ..
  5. Bouatia Naji N, Bonnefond A, Cavalcanti Proença C, Sparsø T, Holmkvist J, Marchand M, et al. A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet. 2009;41:89-94 pubmed publisher
    In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a modulator of fasting plasma glucose (FPG; P = 1.3 x 10(-7))...
  6. Stumpf I, Muhlbauer E, Peschke E. Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells. J Pineal Res. 2008;45:318-27 pubmed publisher
    ..The aim of this study was to examine the relevance of a second melatonin receptor (MT2) as well as the involvement of a third signaling cascade in mediating melatonin effects, i.e...
  7. Levoye A, Dam J, Ayoub M, Guillaume J, Couturier C, Delagrange P, et al. The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. EMBO J. 2006;25:3012-23 pubmed
    ..Pairing orphan GPCRs to potential heterodimerization partners might be of clinical importance and may become a general strategy to better understand the function of orphan GPCRs. ..
  8. Prokopenko I, Langenberg C, Florez J, Saxena R, Soranzo N, Thorleifsson G, et al. Variants in MTNR1B influence fasting glucose levels. Nat Genet. 2009;41:77-81 pubmed publisher
    ..Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies...
  9. Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson A, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010;42:105-16 pubmed publisher
  10. Mazna P, Berka K, Jelinkova I, Balik A, Svoboda P, Obsilova V, et al. Ligand binding to the human MT2 melatonin receptor: the role of residues in transmembrane domains 3, 6, and 7. Biochem Biophys Res Commun. 2005;332:726-34 pubmed
    ..between G-protein-coupled melatonin receptors and their ligands, our previously reported homology model of human MT2 receptor with docked 2-iodomelatonin was further refined and used to select residues within TM3, TM6, and TM7 ..
  11. Tam C, Ho J, Wang Y, Lee H, Lam V, Germer S, et al. Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects. PLoS ONE. 2010;5:e11428 pubmed publisher
    Previous studies identified melatonin receptor 1B (MTNR1B), islet-specific glucose 6 phosphatase catalytic subunit-related protein (G6PC2), glucokinase (GCK) and glucokinase regulatory protein (GCKR) as candidate genes for type 2 diabetes ..
  12. Kan M, Zhou D, Zhang D, Zhang Z, Chen Z, Yang Y, et al. Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort. Diabet Med. 2010;27:598-602 pubmed publisher
    To investigate the two variants (rs1387153 and rs10830963) near/in the melatonin receptor 1B gene (MTNR1B) and to determine their association with Type 2 diabetes, as well as with the regulation of fasting plasma glucose (FPG) in Han ..
  13. Liu C, Wu Y, Li H, Qi Q, Langenberg C, Loos R, et al. MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai. BMC Med Genet. 2010;11:59 pubmed publisher
    ..studies (GWAS) in White Europeans have shown that genetic variation rs10830963 in melatonin receptor 1B gene (MTNR1B) is associated with fasting glucose and type 2 diabetes, which has also been replicated in several Asian ..
  14. Simonis Bik A, Nijpels G, van Haeften T, Houwing Duistermaat J, Boomsma D, Reiling E, et al. Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function. Diabetes. 2010;59:293-301 pubmed publisher
    ..in JAZF1, CDC123/CAMK1D, TSPAN8/LGR5, THADA, ADAMTS9, NOTCH2/ADAMS30, DCD, VEGFA, BCL11A, HNF1B, WFS1, and MTNR1B. Gene variants in CDC123/CAMK1D, ADAMTS9, BCL11A, and MTNR1B affected various aspects of the insulin response to ..
  15. Reiling E, van t Riet E, Groenewoud M, Welschen L, van Hove E, Nijpels G, et al. Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk. Diabetologia. 2009;52:1866-70 pubmed publisher
    ..protein (GCKR), islet-specific glucose 6 phosphatase catalytic subunit-related protein (G6PC2) and melatonin receptor type 1B (MTNR1B) is associated with FPG...
  16. Li C, Qiao B, Zhan Y, Peng W, Chen Z, Sun L, et al. Association between genetic variations in MTNR1A and MTNR1B genes and gestational diabetes mellitus in Han Chinese women. Gynecol Obstet Invest. 2013;76:221-7 pubmed publisher
    The purpose of this study was to investigate the association between MTNR1A and MTNR1B gene polymorphisms and gestational diabetes mellitus (GDM) in Han Chinese women...
  17. Brito E, Lyssenko V, Renstrom F, Berglund G, Nilsson P, Groop L, et al. Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults. Diabetes. 2009;58:1411-8 pubmed publisher
    ..015 and 0.0068, respectively). Our observations suggest that the genetic predisposition to hyperglycemia is partially dependent on a person's lifestyle. ..
  18. Chambers J, Zhang W, Zabaneh D, Sehmi J, Jain P, McCarthy M, et al. Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians. Diabetes. 2009;58:2703-8 pubmed publisher
    ..polymorphisms (SNPs) associated with glucose among Indian Asians at P < 5 x 10(-8), all near melatonin receptor MTNR1B. The most closely associated was rs2166706 (combined P = 2...
  19. Liao S, Liu Y, Tan Y, Gan L, Mei J, Song W, et al. Association of genetic variants of melatonin receptor 1B with gestational plasma glucose level and risk of glucose intolerance in pregnant Chinese women. PLoS ONE. 2012;7:e40113 pubmed publisher
    This study aimed to explore the association of MTNR1B genetic variants with gestational plasma glucose homeostasis in pregnant Chinese women...
  20. Been L, Hatfield J, Shankar A, Aston C, Ralhan S, Wander G, et al. A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: genetic risk is modulated by obesity. Nutr Metab Cardiovasc Dis. 2012;22:944-51 pubmed publisher
    Two common variants (rs1387153, rs10830963) in MTNR1B have been reported to have independent effects on fasting blood glucose (FBG) levels with increased risk to type 2 diabetes (T2D) in recent genome-wide association studies (GWAS)...
  21. Kim J, Cheong H, Park B, Baik S, Park S, Lee S, et al. Melatonin receptor 1 B polymorphisms associated with the risk of gestational diabetes mellitus. BMC Med Genet. 2011;12:82 pubmed publisher
    ..diabetes mellitus (GDM) share similar characteristics, we suspected that the two genetic polymorphisms in MTNR1B may be associated with GDM, and conducted association studies between the polymorphisms and the disease...
  22. Holzapfel C, Siegrist M, Rank M, Langhof H, Grallert H, Baumert J, et al. Association of a MTNR1B gene variant with fasting glucose and HOMA-B in children and adolescents with high BMI-SDS. Eur J Endocrinol. 2011;164:205-12 pubmed publisher
    Genome-wide association studies have shown that the melatonin receptor 1B (MTNR1B) gene locus is strongly associated with fasting glucose and ?-cell function...
  23. Li C, Shi Y, You L, Wang L, Chen Z. Association of rs10830963 and rs10830962 SNPs in the melatonin receptor (MTNR1B) gene among Han Chinese women with polycystic ovary syndrome. Mol Hum Reprod. 2011;17:193-8 pubmed publisher
    The aim of the present study was to determine whether or not the 'melatonin receptor (MTNR1B)' gene polymorphisms are associated with a predisposition for polycystic ovary syndrome (PCOS)...
  24. Qiu X, Tang N, Yeung H, Lee K, Hung V, Ng B, et al. Melatonin receptor 1B (MTNR1B) gene polymorphism is associated with the occurrence of adolescent idiopathic scoliosis. Spine (Phila Pa 1976). 2007;32:1748-53 pubmed
    ..To determine whether melatonin receptor 1B (MTNR1B) gene polymorphisms are associated with the predisposition and/or disease severity of adolescent idiopathic ..
  25. Ingelsson E, Langenberg C, Hivert M, Prokopenko I, Lyssenko V, Dupuis J, et al. Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes. 2010;59:1266-75 pubmed publisher
    ..Abnormalities in early insulin secretion were suggested in glucose-raising allele carriers at MTNR1B, GCK, FADS1, DGKB, and PROX1 (lower insulinogenic index; no association with proinsulin or insulin sensitivity)...
  26. Takeuchi F, Katsuya T, Chakrewarthy S, Yamamoto K, Fujioka A, Serizawa M, et al. Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations. Diabetologia. 2010;53:299-308 pubmed publisher
    ..To test fasting glucose association at four loci recently identified or verified by genome-wide association (GWA) studies of European populations, we performed a replication study in two Asian populations...
  27. Kelliny C, Ekelund U, Andersen L, Brage S, Loos R, Wareham N, et al. Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study. Diabetes. 2009;58:2939-45 pubmed publisher
    ..Single nucleotide polymorphisms in MTNR1B (rs10830963), G6PC2 (rs560887), and GCK (rs4607517) were genotyped in 2,025 healthy European children aged 9-11 ..
  28. Wang Y, Nie M, Li W, Ping F, Hu Y, Ma L, et al. Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population. PLoS ONE. 2011;6:e26953 pubmed publisher
    ..polymorphisms (rs7754840 in CDKAL1, rs391300 in SRR, rs2383208 in CDKN2A/2B, rs4402960 in IGF2BP2, rs10830963 in MTNR1B, rs4607517 in GCK) were genotyped using TaqMan allelic discrimination assays...
  29. Reppert S, Godson C, Mahle C, Weaver D, Slaugenhaupt S, Gusella J. Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. Proc Natl Acad Sci U S A. 1995;92:8734-8 pubmed
    ..The Mel1b receptor cDNA encodes a protein of 362 amino acids that is 60% identical at the amino acid level to the human Mel1a ..
  30. Vlassi M, Gazouli M, Paltoglou G, Christopoulos P, Florentin L, Kassi G, et al. The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population. Hormones (Athens). 2012;11:70-6 pubmed
    ..the association between Gestational Diabetes Mellitus (GDM) and the variants rs10830963 and rs1387153 in the MTNR1B locus in a sample of the Greek population...
  31. Bonnefond A, Clément N, Fawcett K, Yengo L, Vaillant E, Guillaume J, et al. Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. Nat Genet. 2012;44:297-301 pubmed publisher
    Genome-wide association studies have revealed that common noncoding variants in MTNR1B (encoding melatonin receptor 1B, also known as MT(2)) increase type 2 diabetes (T2D) risk(1,2)...
  32. Ayoub M, Couturier C, Lucas Meunier E, Angers S, Fossier P, Bouvier M, et al. Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer. J Biol Chem. 2002;277:21522-8 pubmed
    ..Here, the closely related human MT1 and MT2 melatonin receptors (MT1R, MT2R) were used to address these issues...
  33. Ling Y, Li X, Gu Q, Chen H, Lu D, Gao X. A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individuals. Cardiovasc Diabetol. 2011;10:27 pubmed publisher
    Several studies have shown that common variants in the MTNR1B gene were associated with fasting glucose level and type 2 diabetes...
  34. Jonsson L, Ljunggren E, Bremer A, Pedersen C, Landen M, Thuresson K, et al. Mutation screening of melatonin-related genes in patients with autism spectrum disorders. BMC Med Genomics. 2010;3:10 pubmed publisher
    ..in the melatonin pathway by mutation screening of AA-NAT (arylalkylamine N-acetyltransferase), ASMT, MTNR1A, MTNR1B (melatonin receptor 1A and 1B) and GPR50 (G protein-coupled receptor 50), encoding both synthesis enzymes and the ..
  35. Langenberg C, Pascoe L, Mari A, Tura A, Laakso M, Frayling T, et al. Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response. Diabetologia. 2009;52:1537-42 pubmed publisher
    We investigated whether variation in MTNR1B, which was recently identified as a common genetic determinant of fasting glucose levels in healthy, diabetes-free individuals, is associated with measures of beta cell function and whole-body ..
  36. Anderson B, Schnetz Boutaud N, Bartlett J, Wotawa A, Wright H, Abramson R, et al. Examination of association of genes in the serotonin system to autism. Neurogenetics. 2009;10:209-16 pubmed publisher
    ..01) was found between rs10830962, near MTNR1B (chromosome11; 92,338,075 bp), and rs1007631, near SLC7A5 (chromosome16; 86,413,596 bp)...
  37. Marouli E, Kanoni S, Mamakou V, Hackinger S, Southam L, Prins B, et al. Evaluating the glucose raising effect of established loci via a genetic risk score. PLoS ONE. 2017;12:e0186669 pubmed publisher
    ..019 ± 0.003, P = 1.41e-09. Also, variants at the SLC30A8, PROX1, MTNR1B, ADRA2A, G6PC2, LPIN3 loci indicated nominal evidence for association with glucose levels (p < 0.05)...
  38. Aballay E, Prodan S, Zamorano A, Castaneda Alvarez C. Nematicidal effect of rhizobacteria on plant-parasitic nematodes associated with vineyards. World J Microbiol Biotechnol. 2017;33:131 pubmed publisher
    ..While chitinase and collagenase were measured using the BIOLOG MT2 plate system, protease, hydrogen cyanide and hydrogen sulphide were directly determined in Petri dishes...
  39. Hou L, Yang Y, Shu H, Ying G, Zhao J, Chen Y, et al. Changes in Histopathology, Enzyme Activities, and the Expression of Relevant Genes in Zebrafish (Danio rerio) Following Long-Term Exposure to Environmental Levels of Thallium. Bull Environ Contam Toxicol. 2017;99:574-581 pubmed publisher
    ..The results showed significant increases in HSP70 mRNA expression following exposure to 100 ng/L thallium and in MT2 expression following exposure to 500 ng/L thallium...
  40. Zhao T, Zhang H, Jin C, Qiu F, Wu Y, Shi L. Melatonin mediates vasodilation through both direct and indirect activation of BKCa channels. J Mol Endocrinol. 2017;59:219-233 pubmed publisher
    ..of melatonin was significantly attenuated in the presence of BKCa channel blocker iberiotoxin or MT1/MT2 receptor antagonist luzindole in both (+) l-NAME and (-) l-NAME groups...
  41. Liu Y, Sun X, Feng J, Deng L, Liu Y, Li B, et al. MT2-MMP induces proteolysis and leads to EMT in carcinomas. Oncotarget. 2016;7:48193-48205 pubmed publisher
    ..To investigate the role of membrane-type-2 matrix metalloproteinase (MT2-MMP) in EMT, we generated lentiviral constructs of wild-type (WT) and an inactive Glu260Ala (E260A) mutant MT2-MMP ..
  42. Li Y, Zhou J, Wu Y, Lu T, Yuan M, Cui Y, et al. Association of osteoporosis with genetic variants of circadian genes in Chinese geriatrics. Osteoporos Int. 2016;27:1485-1492 pubmed publisher
    ..647, p = 0.044) but an increased risk between MTNR1B rs3781638 and OP (G/G odds ratio = 2.058, p = 0.044)...
  43. Emeny R, Kasten Jolly J, Mondal T, Lynes M, Lawrence D. Metallothionein differentially affects the host response to Listeria infection both with and without an additional stress from cold-restraint. Cell Stress Chaperones. 2015;20:1013-22 pubmed publisher
    ..responses that occur during stress, using a C57BL/6 (B6) strain that has targeted disruptions of the Mt1 and Mt2 genes (B6-MTKO), and a B6 strain that has additional copies of Mt (B6-MTTGN)...
  44. Drozd A, Wojewska D, Peris Díaz M, Jakimowicz P, Krężel A. Crosstalk of the structural and zinc buffering properties of mammalian metallothionein-2. Metallomics. 2018;10:595-613 pubmed publisher
    ..Recent discoveries indicate that Zn(ii) ions are bound with MT2 with the range from nano- to picomolar affinity, which determines its cellular zinc buffering properties that are ..
  45. Pariente R, Bejarano I, Espino J, Rodriguez A, Pariente J. Participation of MT3 melatonin receptors in the synergistic effect of melatonin on cytotoxic and apoptotic actions evoked by chemotherapeutics. Cancer Chemother Pharmacol. 2017;80:985-998 pubmed publisher
    ..Blockade of MT1 and/or MT2 receptors with luzindole or 4-P-PDOT was unable to reverse the enhancing effects of melatonin on both cytotoxicity, ..
  46. Naija A, Marchand J, Kestemont P, Haouas Z, Blust R, Chénais B, et al. Biomarkers assessment in the peacock blenny Salaria pavo exposed to cadmium. Environ Sci Pollut Res Int. 2016;23:16296-312 pubmed publisher
    ..Partial-length cDNA of mt1, mt2, mnsod, cuznsod, cat, and gpx were characterized...
  47. Naija A, Marchand J, Kestemont P, Haouas Z, Blust R, Chénais B, et al. Mercury accumulation and its effects on molecular, physiological, and histopathological responses in the peacock blenny Salaria pavo. Environ Sci Pollut Res Int. 2016;23:22099-22115 pubmed
    ..In the liver, Hg burden reaches its maximum at day 4 followed also by a decrease. Partial-length cDNA of mt1, mt2, gpx, cat, mnsod and cuznsod was characterized...
  48. Feinberg T, Rowe R, Saunders T, Weiss S. Functional roles of MMP14 and MMP15 in early postnatal mammary gland development. Development. 2016;143:3956-3968 pubmed
    ..thought to depend on the mobilization of the membrane-anchored matrix metalloproteinases MMP14 (MT1-MMP) and MMP15 (MT2-MMP), which drive epithelial cell invasion by remodeling the extracellular matrix and triggering associated ..
  49. Qiu X, Tang N, Yeung H, Qiu Y, Qin L, Lee K, et al. The role of melatonin receptor 1B gene (MTNR1B) in adolescent idiopathic scoliosis--a genetic association study. Stud Health Technol Inform. 2006;123:3-8 pubmed
    ..Using haplotype block tagging technique, a set of tagging SNPs were defined for MTNR1B from the Han Chinese data of the International HapMap project...
  50. Leger D, Quera Salva M, Vecchierini M, Ogrizek P, Perry C, Dressman M. Safety profile of tasimelteon, a melatonin MT1 and MT2 receptor agonist: pooled safety analyses from six clinical studies. Expert Opin Drug Saf. 2015;14:1673-85 pubmed publisher
    ..Tasimelteon is a potent and specific melatonin (MT1 and MT2) receptor agonist with 2 - 4 times greater affinity for the MT2 receptor...
  51. Niles L, Wang J, Shen L, Lobb D, Younglai E. Melatonin receptor mRNA expression in human granulosa cells. Mol Cell Endocrinol. 1999;156:107-10 pubmed
    ..In contrast, expression of MT2 ( Mel1b) mRNA was observed in only two of these HG samples...
  52. Nasrabadi N, Ataee R, Abediankenari S, Shokrzadeh M, Najafi M, Hoseini S, et al. Expression of MT2 receptor in patients with gastric adenocarcinoma and its relationship with clinicopathological features. J Gastrointest Cancer. 2014;45:54-60 pubmed publisher
    ..roles for this neurohormone, this study is initially scheduled to determine the expression of melatonin receptor MT2 in tissue samples of adenocarcinoma cancer patients...
  53. Fan T, Pi H, Li M, Ren Z, He Z, Zhu F, et al. Inhibiting MT2-TFE3-dependent autophagy enhances melatonin-induced apoptosis in tongue squamous cell carcinoma. J Pineal Res. 2017;: pubmed publisher
    ..Luzindole, a melatonin membrane receptor blocker, or MT2-siRNA partially blocked the ability of melatonin to promote mTORC1/TFE3 signaling...
  54. Salman M, Dasgupta S, Cholendra A, Venugopal P, Lakshmi G, Xaviour D, et al. MTNR1B gene polymorphisms and susceptibility to Type 2 Diabetes: A pilot study in South Indians. Gene. 2015;566:189-93 pubmed publisher
    ..A genome-wide association study carried out with non-diabetic Indians showed association of MTNR1B variants with fasting glucose. MTNR1B mediates the effect of melatonin on insulin secretion...
  55. Zhuang Q, Wu Z, Qiu G. [Is polymorphism of CALM1 gene or growth hormone receptor gene associated with susceptibility to adolescent idiopathic scoliosis?]. Zhonghua Yi Xue Za Zhi. 2007;87:2198-202 pubmed
    ..4) The frequency of PPGG (PP = homozygous genotype of GHR gene at I526L, GG = homozygous genotype of MTNR1B gene at rs1562444 locus) of the AIS patients was significantly higher than that of the controls...
  56. Amare A, Schubert K, Klingler Hoffmann M, Cohen Woods S, Baune B. The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies. Transl Psychiatry. 2017;7:e1007 pubmed publisher
    ..NCAN, REST, FTO, POMC, BDNF, CREB, ITIH4, LEP, GSK3B, SLC18A1, TLR4, PPP1R1B, APOE, CRY2, HTR1A, ADRA2A, TCF7L2, MTNR1B and IGF1...
  57. Reinehr T, Scherag A, Wang H, Roth C, Kleber M, Scherag S, et al. Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents. Pediatr Diabetes. 2011;12:435-41 pubmed publisher
    The G-allele of the single nucleotide polymorphism (SNP) rs10830963 in MTNR1B (melatonin receptor 1B gene) is associated with type 2 diabetes mellitus and glucose levels in adults...
  58. Roy D, Angelini N, Fujieda H, Brown G, Belsham D. Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin. Endocrinology. 2001;142:4711-20 pubmed
    ..that GT1-7 GnRH-secreting neurons express membrane-bound G protein-coupled melatonin receptors, mt1 (Mel-1a) and MT2 (Mel-1b) as well as the orphan nuclear receptors ROR alpha and RZR beta...
  59. Oishi A, Karamitri A, Gerbier R, Lahuna O, Ahmad R, Jockers R. Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions. Sci Rep. 2017;7:8990 pubmed publisher
    ..Collectively, these data show that GPR61, GPR62 and GPR135 are unable to bind melatonin, but show a reciprocal regulatory interaction with MT2 receptors. ..
  60. Andersson E, Holst B, Sparsø T, Grarup N, Banasik K, Holmkvist J, et al. MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans. Diabetes. 2010;59:1539-48 pubmed publisher
    Common variants in the melatonin receptor type 1B (MTNR1B) locus have been shown to increase fasting plasma glucose (FPG) and the risk of type 2 diabetes...
  61. Vejl P, Nechybová S, Peřinková P, Melounová M, Sedláková V, Vašek J, et al. Reliable molecular differentiation of Trichuris ovis and Trichuris discolor from sheep (Ovis orientalis aries) and roe deer (Capreolus capreolus) and morphological characterisation of their females: morphology does not work sufficiently. Parasitol Res. 2017;116:2199-2210 pubmed publisher
    ..MT1 and MT4 (vulvar opening on everted vaginal appendage/on visible cuticular bulge) occurred only in T. ovis, MT2 (uneverted vagina-vulvar opening without any elevation) was identified only in T...
  62. Natarajan R, Einarsdottir E, Riutta A, Hagman S, Raunio M, Mononen N, et al. Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients. J Neuroimmunol. 2012;250:106-10 pubmed publisher
    ..tryptophan hydroxylases (TPH)1 and 2, arylalkylamine N-acetyltransferase (AANAT) and melatonin receptor 1B (MTNR1B)...
  63. Byrne E, Johnson J, McRae A, Nyholt D, Medland S, Gehrman P, et al. A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor. Sleep. 2012;35:967-75 pubmed publisher
    ..They will require replication in another sample. The results may have implications for understanding the biologic mechanisms underlying insomnia. ..
  64. Zhou J, Wang D, Luo X, Jia X, Li M, Laudon M, et al. Melatonin Receptor Agonist Piromelatine Ameliorates Impaired Glucose Metabolism in Chronically Stressed Rats Fed a High-Fat Diet. J Pharmacol Exp Ther. 2018;364:55-69 pubmed publisher
    ..Piromelatine is a melatonin receptor-1/melatonin receptor-2 (MT1/MT2) agonist with high affinity for MLT receptors and a longer duration of action than MLT...
  65. Junior J, Frigeri H, Dos Santos Weiss I, de Souza E, Rego F, Picheth G, et al. The MTNR1B gene polymorphism rs10830963 is associated with gestational diabetes in a Brazilian population. Gene. 2015;568:114-5 pubmed publisher
  66. Song X, Sun X, Ma G, Sun Y, Shi Y, Du Y, et al. Family association study between melatonin receptor gene polymorphisms and polycystic ovary syndrome in Han Chinese. Eur J Obstet Gynecol Reprod Biol. 2015;195:108-12 pubmed publisher
    ..5983, p=0.018). This study may provide a basis for further studies of the MTNR gene in the aetiology of PCOS. ..
  67. Wang X, Wu X, Liu Q, Kong G, Zhou J, Jiang J, et al. Ketogenic Metabolism Inhibits Histone Deacetylase (HDAC) and Reduces Oxidative Stress After Spinal Cord Injury in Rats. Neuroscience. 2017;366:36-43 pubmed publisher
    ..Anti-oxidative stress genes Foxo3a and Mt2 and related proteins, such as mitochondrial superoxide dismutase (SOD), FOXO3a, catalase were increased in dietary ..
  68. Kamal M, Gbahou F, Guillaume J, Daulat A, Benleulmi Chaachoua A, Luka M, et al. Convergence of melatonin and serotonin (5-HT) signaling at MT2/5-HT2C receptor heteromers. J Biol Chem. 2015;290:11537-46 pubmed publisher
    ..The present study reveals a hitherto unrecognized cross-talk mediated via physical association of melatonin MT2 and 5-HT2C receptors into functional heteromers...
  69. Go M, Hwang J, Kim Y, Hee Oh J, Kim Y, Heon Kwak S, et al. New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population. J Hum Genet. 2013;58:362-5 pubmed publisher
    ..We also demonstrated associations with gestational diabetes mellitus. Our results could provide additional insight into the genetic variation in the clinical range of glycemia. ..