Gene Symbol: MTMR4
Description: myotubularin related protein 4
Alias: FYVE-DSP2, ZFYVE11, myotubularin-related protein 4, FYVE domain-containing dual specificity protein phosphatase 2, zinc finger FYVE domain-containing protein 11, zinc finger, FYVE domain containing 11
Species: human
Products:     MTMR4

Top Publications

  1. Zhao R, Qi Y, Chen J, Zhao Z. FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate. Exp Cell Res. 2001;265:329-38 pubmed
    ..Together with two homologous hypothetical proteins found in Caenorhabditis elegans and Drosophila, FYVE-DSP1 and FYVE-DSP2 form a subfamilyof phosphatases that may have an importantrole in cellular processes. ..
  2. Lorenzo O, Urbé S, Clague M. Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. J Cell Sci. 2006;119:2953-9 pubmed
    ..previously reported combinations and identified novel heteromeric interactions: MTMR8 with MTMR9, and MTMR3 with MTMR4, the first such combination of enzymatically active MTMs...
  3. Naughtin M, Sheffield D, Rahman P, Hughes W, Gurung R, Stow J, et al. The myotubularin phosphatase MTMR4 regulates sorting from early endosomes. J Cell Sci. 2010;123:3071-83 pubmed publisher
    ..Here, we identify the myotubularin family member MTMR4, which localizes to early endosomes and also to Rab11- and Sec15-positive recycling endosomes...
  4. Iranmehr A, Stobdan T, Zhou D, Poulsen O, Strohl K, Aldashev A, et al. Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders. Eur J Hum Genet. 2019;27:150-159 pubmed publisher
    ..We show here evidence of three candidate genes MTMR4, TMOD3 and VCAM1 that are functionally associated with well-known molecular and pathophysiological processes and ..
  5. Bourgonje A, Verrijp K, Schepens J, Navis A, Piepers J, Palmen C, et al. Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma. Acta Neuropathol Commun. 2016;4:96 pubmed publisher
    ..Notably, seven PTP genes (DUSP26, MTMR4, PTEN, PTPRM, PTPRN2, PTPRT and PTPRZ1) were differentially expressed between grade II-III gliomas and (grade IV) ..
  6. Avela K, Lipsanen Nyman M, Idänheimo N, Seemanova E, Rosengren S, Mäkelä T, et al. Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism. Nat Genet. 2000;25:298-301 pubmed
    ..MUL is ubiquitously expressed and encodes a new member of the RING-B-box-Coiled-coil (RBCC) family of zinc-finger proteins, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. ..
  7. Yu J, Pan L, Qin X, Chen H, Xu Y, Chen Y, et al. MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes. J Biol Chem. 2010;285:8454-62 pubmed publisher
    ..Here we demonstrate that myotubularin-related protein 4 (MTMR4), a FYVE domain-containing dual-specificity protein phosphatase (DSP), attenuates TGFbeta signaling by reducing ..
  8. Dolley G, Lamarche B, Despres J, Bouchard C, Perusse L, Vohl M. Phosphoinositide cycle gene polymorphisms affect the plasma lipid profile in the Quebec Family Study. Mol Genet Metab. 2009;97:149-54 pubmed publisher
    ..this region according to their implication in the phosphoinositide (PI) cycle: the myotubularin-related protein 4 (MTMR4), the phospholipase C, delta 3 (PLCD3), and the diacylglycerol kinase E (DGKE) genes...
  9. Lee J, Son J, Yoo K, Shin W, Im D, Kim S, et al. Crystallization and preliminary X-ray crystallographic analysis of the PH-GRAM domain of human MTMR4. Acta Crystallogr F Struct Biol Commun. 2014;70:1280-3 pubmed publisher
    ..In this study, the PH-GRAM domain of human MTMR4 was cloned, overexpressed in Escherichia coli, purified and crystallized by the vapour-diffusion method...

More Information


  1. Anderson D, Holt B, Pennell C, Holt P, Hart P, Blackwell J. Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study. Genes Immun. 2014;15:578-83 pubmed publisher
    ..3 × 10(-6)) that could be of functional interest in highlighting alternative pathways for vitamin D metabolism in this age group and merits further analysis in other cohort studies. ..
  2. St Denis N, Gupta G, Lin Z, Gonzalez Badillo B, Pelletier L, Gingras A. Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission. Mol Cell Proteomics. 2015;14:946-60 pubmed publisher
    ..This work provides a novel role for myotubularin-related protein 3/4 heterodimers, and highlights the temporal and spatial complexity of the regulation of cytokinesis. ..
  3. Hao F, Itoh T, Morita E, Shirahama Noda K, Yoshimori T, Noda T. The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity. FEBS Lett. 2016;590:161-73 pubmed publisher
    ..Furthermore, phosphatase-deficient full length MTMR3 and the phosphatase domain alone were localized to the Golgi. These results suggest a new regulatory mechanism of mTORC1 in association with PI3P. ..
  4. Teo W, Kerr M, Teasdale R. MTMR4 Is Required for the Stability of the Salmonella-Containing Vacuole. Front Cell Infect Microbiol. 2016;6:91 pubmed publisher
    ..While the phosphoinositide 3-phosphatase myotubularin 4 (MTMR4) has an established role in regulating autophagy and cellular PI(3)P-content, two processes associated with the ..
  5. Laporte J, Blondeau F, Buj Bello A, Tentler D, Kretz C, Dahl N, et al. Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human. Hum Mol Genet. 1998;7:1703-12 pubmed
    ..Comparison of the various genes allowed construction of a phylogenetic tree and reveals conserved residues which may be essential for function. These genes may be good candidates for other genetic diseases. ..
  6. Shaffer J, Wang X, Feingold E, Lee M, Begum F, Weeks D, et al. Genome-wide association scan for childhood caries implicates novel genes. J Dent Res. 2011;90:1457-62 pubmed publisher
    ..Verification/replication of suggestive loci may highlight biological mechanisms and/or pathways leading to a fuller understanding of the genetic risks for dental caries. ..
  7. Yu J, He X, Chen Y, Hao Y, Yang S, Wang L, et al. Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins. J Biol Chem. 2013;288:79-88 pubmed publisher
    ..Herein we demonstrated that myotubularin-related protein 4 (MTMR4), a FYVE domain-containing dual-specificity protein phosphatase (DUSP), preferentially associated with and ..
  8. Plant P, Correa J, Goldenberg N, Bain J, Batt J. The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4. Biochem J. 2009;419:57-63 pubmed publisher
    The inositol phosphatase, MTMR4 (myotubularin-related protein 4), was identified as a novel interactor of the ubiquitin ligase Nedd4 (neural-precursor-cell-expressed developmentally down-regulated 4)...