MTCH2

Summary

Gene Symbol: MTCH2
Description: mitochondrial carrier 2
Alias: HSPC032, MIMP, SLC25A50, mitochondrial carrier homolog 2, 2310034D24Rik, met-induced mitochondrial protein, solute carrier family 25, member 50
Species: human
Products:     MTCH2

Top Publications

  1. Willer C, Speliotes E, Loos R, Li S, Lindgren C, Heid I, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009;41:25-34 pubmed publisher
    ..strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant)...
  2. Bauer F, Elbers C, Adan R, Loos R, Onland Moret N, Grobbee D, et al. Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am J Clin Nutr. 2009;90:951-9 pubmed publisher
    ..They were in or near to 6 loci: FTO, MC4R, KCTD15, MTCH2, NEGR1, and BDNF. Five SNPs were associated with dietary intake (P < 0...
  3. Li S, Zhao J, Luan J, Luben R, Rodwell S, Khaw K, et al. Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. Am J Clin Nutr. 2010;91:184-90 pubmed publisher
    ..These variants have cumulative effects, yet their predictive value for obesity risk is limited. ..
  4. Jiang Q, Sun B, Liu Q, Cai M, Wu R, Wang F, et al. MTCH2 promotes adipogenesis in intramuscular preadipocytes via an m6A-YTHDF1-dependent mechanism. FASEB J. 2019;33:2971-2981 pubmed publisher
    ..Furthermore, we identified a unique methylated gene in Jinhua pigs named mitochondrial carrier homology 2 ( MTCH2)...
  5. Williams M, Almén M, Fredriksson R, Schioth H. What model organisms and interactomics can reveal about the genetics of human obesity. Cell Mol Life Sci. 2012;69:3819-34 pubmed publisher
    ..cadm2, gipr, gpcr5b, lrp1b, negr1, nrxn3, sh2b1, fancl, gnpda2, hmgcr, map2k5, nudt3, prkd1, qpctl, tnni3k, mtch2, dnajc27, slc39a8, mtif3, rpl27a, sec16b, etv5, hmga1, tfap2b, tub, znf608, faim2, kctd15, lingo2, poc5, ptbp2, ..
  6. Bahat A, Goldman A, Zaltsman Y, Khan D, Halperin C, Amzallag E, et al. MTCH2-mediated mitochondrial fusion drives exit from naïve pluripotency in embryonic stem cells. Nat Commun. 2018;9:5132 pubmed publisher
    ..Here we report that mitochondrial MTCH2 is a regulator of mitochondrial fusion, essential for the naïve-to-primed interconversion of murine embryonic ..
  7. Broce I, Tan C, Fan C, Jansen I, Savage J, Witoelar A, et al. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease. Acta Neuropathol. 2019;137:209-226 pubmed publisher
    ..98 × 10-7) and two chromosome 11 SNPs within the MTCH2/SPI1 region (closest gene = DDB2, meta-p = 7...
  8. Aloni E, Ruggiero A, Gross A, Segal M. Learning Deficits in Adult Mitochondria Carrier Homolog 2 Forebrain Knockout Mouse. Neuroscience. 2018;394:156-163 pubmed publisher
    b>Mitochondrial Carrier Homolog 2 (MTCH2) acts as a receptor for the BH3 interacting-domain death agonist (BID) in the mitochondrial outer membrane. Loss of MTCH2 affects mitochondria energy metabolism and function...
  9. Ruggiero A, Aloni E, Korkotian E, Zaltsman Y, Oni Biton E, Kuperman Y, et al. Loss of forebrain MTCH2 decreases mitochondria motility and calcium handling and impairs hippocampal-dependent cognitive functions. Sci Rep. 2017;7:44401 pubmed publisher
    b>Mitochondrial Carrier Homolog 2 (MTCH2) is a novel regulator of mitochondria metabolism, which was recently associated with Alzheimer's disease...

More Information

Publications45

  1. Graff M, Gordon Larsen P, Lim U, Fowke J, Love S, Fesinmeyer M, et al. The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study. Diabetes. 2013;62:1763-7 pubmed publisher
    ..evidence for heterogeneity in the associations of five established obesity risk variants (near FTO, GNPDA2, MTCH2, TMEM18, and NEGR1) with BMI across four distinct epochs of adulthood: 1) young adulthood (ages 18-25 years), ..
  2. Maryanovich M, Zaltsman Y, Ruggiero A, Goldman A, Shachnai L, Zaidman S, et al. An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate. Nat Commun. 2015;6:7901 pubmed publisher
    ..Here we show that loss of mitochondrial carrier homologue 2 (MTCH2) increases mitochondrial OXPHOS, triggering HSC and progenitor entry into cycle...
  3. Bandstein M, Voisin S, Nilsson E, Schultes B, Ernst B, Thurnheer M, et al. A Genetic Risk Score Is Associated with Weight Loss Following Roux-en Y Gastric Bypass Surgery. Obes Surg. 2016;26:2183-2189 pubmed publisher
    ..of seven BMI-associated SNPs (closest genes: MC4R, TMEM160, PTBP2, NUDT3, TFAP2B, ZNF608, MAP2K5, GNPDA2, and MTCH2) and of three WHR-associated SNPs (closest genes: HOXC13, LYPLAL1, and DNM3-PIGC)...
  4. Graff M, North K, Richardson A, Young K, Mazul A, Highland H, et al. BMI loci and longitudinal BMI from adolescence to young adulthood in an ethnically diverse cohort. Int J Obes (Lond). 2017;41:759-768 pubmed publisher
    ..We found SNPs in/near FTO, MC4R, MTCH2, TFAP2B, SEC16B and TMEM18 were significantly associated (P<0.0015≈0...
  5. Goldman A, Rodríguez Casuriaga R, González López E, Capoano C, Santiñaque F, Geisinger A. MTCH2 is differentially expressed in rat testis and mainly related to apoptosis of spermatocytes. Cell Tissue Res. 2015;361:869-83 pubmed publisher
    b>MTCH2 has been described in liver as a protein involved in the intrinsic apoptotic pathway, although new evidence also associates this protein with cellular metabolism...
  6. Kilpeläinen T, den Hoed M, Ong K, Grøntved A, Brage S, Jameson K, et al. Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals. Am J Clin Nutr. 2011;93:851-60 pubmed publisher
    ..examine the associations of 12 established BMI variants in or near the NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, BCDIN3D, SH2B1, FTO, MC4R, and KCTD15 genes and their additive score with birth weight...
  7. Bar Lev Y, Moshitch Moshkovitz S, Tsarfaty G, Kaufman D, Horev J, Resau J, et al. Mimp/Mtch2, an Obesity Susceptibility Gene, Induces Alteration of Fatty Acid Metabolism in Transgenic Mice. PLoS ONE. 2016;11:e0157850 pubmed publisher
    ..Mimp/Mtch2 is a mitochondrial carrier protein homologue, which localizes to the mitochondria and induces mitochondrial ..
  8. Xu B, Zhang Y, Zhan S, Wang X, Zhang H, Meng X, et al. Proteomic Profiling of Brain and Testis Reveals the Diverse Changes in Ribosomal Proteins in fmr1 Knockout Mice. Neuroscience. 2018;371:469-483 pubmed publisher
    ..Proteins (FMRP, RPS8, RPL23a and ATPIF1, RPL6, GAP43, MTCH2 and MPZ in brain, and FMRP, CAH3, AKR1B7 and C9 in testis) identified by MS/MS were also verified by Western ..
  9. Rönn T, Volkov P, Gillberg L, Kokosar M, Perfilyev A, Jacobsen A, et al. Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood. Hum Mol Genet. 2015;24:3792-813 pubmed publisher
    ..We identified 2825 genes (e.g. FTO, ITIH5, CCL18, MTCH2, IRS1 and SPP1) where both DNA methylation and expression correlated with BMI...
  10. Shamas Din A, Bindner S, Chi X, Leber B, Andrews D, Fradin C. Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax. Biochem J. 2015;467:495-505 pubmed publisher
    ..This suggests that CL can activate tBid in a similar manner to Mtch2 (mitochondrial carrier homologue 2)...
  11. Buzaglo Azriel L, Kuperman Y, Tsoory M, Zaltsman Y, Shachnai L, Zaidman S, et al. Loss of Muscle MTCH2 Increases Whole-Body Energy Utilization and Protects from Diet-Induced Obesity. Cell Rep. 2016;14:1602-1610 pubmed publisher
    b>Mitochondrial carrier homolog 2 (MTCH2) is a repressor of mitochondrial oxidative phosphorylation (OXPHOS), and its locus is associated with increased BMI in humans...
  12. Rottiers V, Francisco A, Platov M, Zaltsman Y, Ruggiero A, Lee S, et al. MTCH2 is a conserved regulator of lipid homeostasis. Obesity (Silver Spring). 2017;25:616-625 pubmed publisher
    ..The functional role of mitochondrial carrier homolog 2 (MTCH2), a human obesity-associated gene, in lipid homeostasis was investigated in Caenorhabditis ..
  13. Karch C, Ezerskiy L, Bertelsen S, Goate A. Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. PLoS ONE. 2016;11:e0148717 pubmed publisher
    ..Rs7120548 was associated with MTCH2 expression, which occurs within the CELF1 locus...
  14. Katz C, Zaltsman Amir Y, Mostizky Y, Kollet N, Gross A, Friedler A. Molecular basis of the interaction between proapoptotic truncated BID (tBID) protein and mitochondrial carrier homologue 2 (MTCH2) protein: key players in mitochondrial death pathway. J Biol Chem. 2012;287:15016-23 pubmed publisher
    The molecular basis of the interaction between mitochondrial carrier homologue 2 (MTCH2) and truncated BID (tBID) was characterized...
  15. Landgraf K, Strobach A, Kiess W, Körner A. Loss of mtch2 function impairs early development of liver, intestine and visceral adipocytes in zebrafish larvae. FEBS Lett. 2016;590:2852-61 pubmed publisher
    The mitochondrial carrier homologue 2 (MTCH2) has been shown to be essential for embryogenesis in mice, and variants in the MTCH2 locus have been linked to obesity in humans...
  16. Raemy E, Montessuit S, Pierredon S, van Kampen A, Vaz F, Martinou J. Cardiolipin or MTCH2 can serve as tBID receptors during apoptosis. Cell Death Differ. 2016;23:1165-74 pubmed publisher
    ..it is still unclear whether this process also relies on CL in the cell, or whether it is more dependent on MTCH2, a proposed receptor for tBID present in the MOM...
  17. Shamas Din A, Bindner S, Zhu W, Zaltsman Y, Campbell C, Gross A, et al. tBid undergoes multiple conformational changes at the membrane required for Bax activation. J Biol Chem. 2013;288:22111-27 pubmed publisher
    ..Using automated high-throughput image analysis in cells, we show that down-regulation of Mtch2 causes a significant delay between tBid and Bax relocalization in cells...
  18. Renström F, Payne F, Nordström A, Brito E, Rolandsson O, Hallmans G, et al. Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. Hum Mol Genet. 2009;18:1489-96 pubmed publisher
    ..studies (GWAS) have identified multiple risk loci for common obesity (FTO, MC4R, TMEM18, GNPDA2, SH2B1, KCTD15, MTCH2, NEGR1 and PCSK1)...
  19. Brandys M, Van Elburg A, Loos R, Bauer F, Hendriks J, van der Schouw Y, et al. Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:695-699 pubmed publisher
    ..The percentages of BMI-increasing alleles were equal between cases and controls. This study found no evidence that genetic variants regulating BMI in the general population are significantly associated with susceptibility to AN. ..
  20. Hotta K, Nakamura M, Nakamura T, Matsuo T, Nakata Y, Kamohara S, et al. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. J Hum Genet. 2009;54:727-31 pubmed publisher
    ..deaminase 2 (GNPDA2), prolactin (PRL), brain-derived neurotrophic factor (BDNF), mitochondrial carrier homolog 2 (MTCH2), Fas apoptotic inhibitory molecule 2 (FAIM2), SH2B adaptor protein 1 (SH2B1), v-maf ..
  21. He M, Cornelis M, Franks P, Zhang C, Hu F, Qi L. Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol. 2010;30:327-32 pubmed publisher
    ..Four polymorphisms (rs9939609 [FTO], rs11084753 [KCTD15], rs10838738 [MTCH2], and rs10938397 [GNPDA2]) showed nominally significant associations with CVD...
  22. Ng M, Tam C, So W, Ho J, Chan A, Lee H, et al. Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. J Clin Endocrinol Metab. 2010;95:2418-25 pubmed publisher
    ..14 associated single-nucleotide polymorphisms at 12 loci (NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15) in 605 healthy adults, 1087 healthy adolescents and 6013 T2D ..
  23. Eswarappa S, Potdar A, Koch W, Fan Y, Vasu K, Lindner D, et al. Programmed translational readthrough generates antiangiogenic VEGF-Ax. Cell. 2014;157:1605-18 pubmed publisher
    ..Furthermore, genome-wide analysis revealed AGO1 and MTCH2 as authentic readthrough targets...
  24. Bernhard F, Landgraf K, Kloting N, Berthold A, Buttner P, Friebe D, et al. Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology. Diabetologia. 2013;56:311-22 pubmed publisher
    ..We investigated the functional relevance of such genes in human adipocytes...
  25. Gross A. BCL-2 family proteins as regulators of mitochondria metabolism. Biochim Biophys Acta. 2016;1857:1243-1246 pubmed publisher
    ..link between mitochondrial metabolism/dynamics and the fate of stem cells, with an emphasis on the role of the BID-MTCH2 pair in regulating this link...
  26. Tan C, Zhou Q, Su Y, Fu N, Chang H, Tao R, et al. MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria. Cell Rep. 2016;16:174-185 pubmed publisher
    ..Subsequent tBid recruitment to mitochondria, which is facilitated by its receptor MTCH2 at the outer mitochondrial membrane (OMM), is a critical step for commitment to apoptosis via the effector ..
  27. Haupt A, Thamer C, Heni M, Machicao F, Machann J, Schick F, et al. Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study. Obesity (Silver Spring). 2010;18:1212-7 pubmed publisher
    ..single-nucleotide polymorphisms (SNPs) TMEM18 rs6548238, KCTD15 rs11084753, GNPDA2 rs10938397, SH2B1 rs7498665, MTCH2 rs10838738, and NEGR1 rs2815752...
  28. Yerushalmi G, Leibowitz Amit R, Shaharabany M, Tsarfaty I. Met-HGF/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization. Neoplasia. 2002;4:510-22 pubmed
    ..Using differential display polymerase chain reaction, we cloned a novel gene, designated mimp (Met-Induced Mitochondrial Protein), which is upregulated in NIH-3T3 cells cotransfected with both HGF/SF and Met (..
  29. Grinberg M, Schwarz M, Zaltsman Y, Eini T, Niv H, Pietrokovski S, et al. Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol Cell Biol. 2005;25:4579-90 pubmed
    ..Here we describe the biochemical purification of this complex and the identification of mitochondrial carrier homolog 2 (Mtch2) as part of this complex...
  30. Zhang T, Hu Y, Wang T, Cai P. Dihydroartemisinin inhibits the viability of cervical cancer cells by upregulating caveolin 1 and mitochondrial carrier homolog 2: Involvement of p53 activation and NAD(P)H:quinone oxidoreductase 1 downregulation. Int J Mol Med. 2017;40:21-30 pubmed publisher
    ..that DHA treatment induced the upregulation of caveolin 1 (Cav1) and mitochondrial carrier homolog 2 (MTCH2) in HeLa cells, and this was associated with the DHA-induced inhibition of cell viability and DHA-induced ..
  31. Holzapfel C, Grallert H, Huth C, Wahl S, Fischer B, Doring A, et al. Genes and lifestyle factors in obesity: results from 12,462 subjects from MONICA/KORA. Int J Obes (Lond). 2010;34:1538-45 pubmed publisher
    ..The association of seven polymorphisms in or near the genes NEGR1, TMEM18, MTCH2, FTO, MC4R, SH2B1 and KCTD15 was analyzed in 12,462 subjects from the population-based MONICA/KORA Augsburg study...
  32. Orkunoglu Suer F, Harmon B, Gordish Dressman H, Clarkson P, Thompson P, Angelopoulos T, et al. MC4R variant is associated with BMI but not response to resistance training in young females. Obesity (Silver Spring). 2011;19:662-6 pubmed publisher
  33. Delahanty L, Pan Q, Jablonski K, Watson K, McCaffery J, SHULDINER A, et al. Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program. Diabetes Care. 2012;35:363-6 pubmed publisher
    ..We tested genetic associations with weight loss and weight regain in the Diabetes Prevention Program, a randomized controlled trial of weight loss-inducing interventions (lifestyle and metformin) versus placebo...
  34. Fall T, Arnlov J, Berne C, Ingelsson E. The role of obesity-related genetic loci in insulin sensitivity. Diabet Med. 2012;29:e62-6 pubmed publisher
    ..Three loci (SH2B1, MTCH2 and NEGR1) were associated with decreased insulin sensitivity at a nominal significance (P ? 0...
  35. den Hoed M, Ekelund U, Brage S, Grontved A, Zhao J, Sharp S, et al. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies. Diabetes. 2010;59:2980-8 pubmed publisher
    ..Whereas the association of some variants may differ with age, the cumulative effect size is similar. ..
  36. Kulyté A, Ryden M, Mejhert N, Dungner E, Sjölin E, Arner P, et al. MTCH2 in human white adipose tissue and obesity. J Clin Endocrinol Metab. 2011;96:E1661-5 pubmed publisher
    ..One obesity-associated single-nucleotide polymorphism is close to the MTCH2 gene (mitochondrial carrier homolog 2)...