MTAP

Summary

Gene Symbol: MTAP
Description: methylthioadenosine phosphorylase
Alias: BDMF, DMSFH, DMSMFH, LGMBF, MSAP, c86fus, 5'-methylthioadenosine phosphorylase, MTA phosphorylase, MTAPase, MeSAdo phosphorylase, S-methyl-5'-thioadenosine phosphorylase
Species: human

Top Publications

  1. pmc Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi
    Mario Falchi
    Department of Twin Research and Genetic Epidemiology, Kings College London, St Thomas Hospital Campus, London, UK
    Nat Genet 41:915-9. 2009
  2. ncbi The structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase at 1.7 A resolution provides insights into substrate binding and catalysis
    T C Appleby
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853, USA
    Structure 7:629-41. 1999
  3. pmc Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom
    Julia A Newton-Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St James s Hospital, Beckett Street, Leeds, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:2043-54. 2010
  4. pmc Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis
    Maya Berg
    Laboratory of Medicinal Chemistry, University of Antwerp, Antwerp, Belgium
    Antimicrob Agents Chemother 54:1900-8. 2010
  5. ncbi Purification and characterization of extremely thermophilic and thermostable 5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus. Purine nucleoside phosphorylase activity and evidence for intersubunit disulfide bonds
    G Cacciapuoti
    Institute of Biochemistry of Macromolecules, Faculty of Medicine, Second University of Naples, Italy
    J Biol Chem 269:24762-9. 1994
  6. ncbi Biochemical and structural characterization of mammalian-like purine nucleoside phosphorylase from the Archaeon Pyrococcus furiosus
    Giovanna Cacciapuoti
    Dipartimento di Biochimica e Biofisica F Cedrangolo, Seconda Universita di Napoli, Napoli, Italy
    FEBS J 274:2482-95. 2007
  7. ncbi Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus
    T C Appleby
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 276:39232-42. 2001
  8. ncbi Endosperm-specific hypomethylation, and meiotic inheritance and variation of DNA methylation level and pattern in sorghum (Sorghum bicolor L.) inter-strain hybrids
    M S Zhang
    Laboratory of Plant Molecular Epigenetics, Institute of Genetics and Cytology, Northeast Normal University, Changchun, 130024, China
    Theor Appl Genet 115:195-207. 2007
  9. doi Purine nucleoside phosphorylases from hyperthermophilic Archaea require a CXC motif for stability and folding
    Giovanna Cacciapuoti
    Department of Biochemistry and Biophysics F Cedrangolo, Second University of Naples, Italy
    FEBS J 276:5799-805. 2009
  10. ncbi Purification and characterization of 5'-methylthioadenosine phosphorylase from the hyperthermophilic archaeon Pyrococcus furiosus: substrate specificity and primary structure analysis
    Giovanna Cacciapuoti
    Dipartimento di Biochimica e Biofisica F Cedrangolo, Seconda Universita di Napoli, Via Costantinopoli 16, 80138, Naples, Italy
    Extremophiles 7:159-68. 2003

Research Grants

Detail Information

Publications162 found, 100 shown here

  1. pmc Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi
    Mario Falchi
    Department of Twin Research and Genetic Epidemiology, Kings College London, St Thomas Hospital Campus, London, UK
    Nat Genet 41:915-9. 2009
    ..We identified strongly associated variants in MTAP, a gene adjacent to the familial melanoma susceptibility locus CDKN2A on 9p21 (rs4636294, combined P = 3...
  2. ncbi The structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase at 1.7 A resolution provides insights into substrate binding and catalysis
    T C Appleby
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853, USA
    Structure 7:629-41. 1999
    5'-Deoxy-5'-methylthioadenosine phosphorylase (MTAP) catalyzes the reversible phosphorolysis of 5'-deoxy-5'-methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1-phosphate...
  3. pmc Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom
    Julia A Newton-Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St James s Hospital, Beckett Street, Leeds, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:2043-54. 2010
    ..Increased number of melanocytic nevi is a potent melanoma risk factor. We have carried out a large population-based case-control study to explore the environmental and genetic determinants of nevi and the relationship with melanoma risk...
  4. pmc Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis
    Maya Berg
    Laboratory of Medicinal Chemistry, University of Antwerp, Antwerp, Belgium
    Antimicrob Agents Chemother 54:1900-8. 2010
    ..b. brucei (IAG-NH, IG-NH, and methylthioadenosine phosphorylase [MTAP]) were investigated using RNA interference...
  5. ncbi Purification and characterization of extremely thermophilic and thermostable 5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus. Purine nucleoside phosphorylase activity and evidence for intersubunit disulfide bonds
    G Cacciapuoti
    Institute of Biochemistry of Macromolecules, Faculty of Medicine, Second University of Naples, Italy
    J Biol Chem 269:24762-9. 1994
    ..solfataricus the same enzyme is responsible for the catabolism of MTA and of these purine nucleosides...
  6. ncbi Biochemical and structural characterization of mammalian-like purine nucleoside phosphorylase from the Archaeon Pyrococcus furiosus
    Giovanna Cacciapuoti
    Dipartimento di Biochimica e Biofisica F Cedrangolo, Seconda Universita di Napoli, Napoli, Italy
    FEBS J 274:2482-95. 2007
    ..a homohexamer of 180 kDa which shows a much higher similarity with 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) than with purine nucleoside phosphorylase (PNP) family members...
  7. ncbi Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus
    T C Appleby
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 276:39232-42. 2001
    ..Examination of the three-dimensional structure of SsMTAP suggests that unlike most thermophilic enzymes, disulfide linkages play a key in role in its thermal stability...
  8. ncbi Endosperm-specific hypomethylation, and meiotic inheritance and variation of DNA methylation level and pattern in sorghum (Sorghum bicolor L.) inter-strain hybrids
    M S Zhang
    Laboratory of Plant Molecular Epigenetics, Institute of Genetics and Cytology, Northeast Normal University, Changchun, 130024, China
    Theor Appl Genet 115:195-207. 2007
    ..parents, the developmental stability and inheritance of cytosine methylation in two tissues, leaf and endosperm, by MSAP analysis were investigated...
  9. doi Purine nucleoside phosphorylases from hyperthermophilic Archaea require a CXC motif for stability and folding
    Giovanna Cacciapuoti
    Department of Biochemistry and Biophysics F Cedrangolo, Second University of Naples, Italy
    FEBS J 276:5799-805. 2009
    ..The data obtained in the present study represent the first example of how the CXC motif improves both stability and folding in hyperthermophilic proteins with disulfide bonds...
  10. ncbi Purification and characterization of 5'-methylthioadenosine phosphorylase from the hyperthermophilic archaeon Pyrococcus furiosus: substrate specificity and primary structure analysis
    Giovanna Cacciapuoti
    Dipartimento di Biochimica e Biofisica F Cedrangolo, Seconda Universita di Napoli, Via Costantinopoli 16, 80138, Naples, Italy
    Extremophiles 7:159-68. 2003
    5'-Methylthioadenosine phosphorylase (MTAP) was purified to homogeneity from the hyperthermophilic archaeon Pyrococcus furiosus. The protein is a homoexamer of 180 kDa...
  11. doi Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases
    Gary B Evans
    Carbohydrate Chemistry Team, Industrial Research Limited, PO Box 31310, Lower Hutt, New Zealand
    J Med Chem 51:948-56. 2008
    ..inhibitors (equilibrium dissociation constants as low as 229 pM) of purine nucleoside phosphorylase (PNP), methylthioadenosine phosphorylase (MTAP), and methylthioadenosine nucleosidase (MTAN), with potential utility as drug candidates.
  12. pmc Molecular characterization of a rice mutator-phenotype derived from an incompatible cross-pollination reveals transgenerational mobilization of multiple transposable elements and extensive epigenetic instability
    Hongyan Wang
    Key Laboratory of Molecular Epigenetics of MOE and Institute of Genetics and Cytology, Northeast Normal University, Changchun, PR China
    BMC Plant Biol 9:63. 2009
    ....
  13. ncbi Influence of cryopreservation on the cytosine methylation state of potato genomic NDA
    Anja Kaczmarczyk
    Leibniz Institute of Plant Genetics and Crop Plant Research IPK, Gatersleben, Germany
    Cryo Letters 31:380-91. 2010
    ..epigenetic changes, the DNA methylation status was assayed by methylation-sensitive amplified polymorphism (MSAP) analysis using restriction endonucleases MspI and HpaII. An amount of 93...
  14. ncbi Extremely thermophilic and thermostable 5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus. Gene cloning and amino acid sequence determination
    G Cacciapuoti
    Istituto di Biochimica delle Macromolecole, Facolta di Medicina e Chirurgia, Seconda Universita degli Studi di Napoli, Italy
    Eur J Biochem 239:632-7. 1996
    ..Evolutionary and structural implications of this similarity are discussed...
  15. ncbi Sympathoadrenal reactions during asphyxia in hypoglycemia and hyperglycemia of cats
    S W Kuo
    Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Chin J Physiol 37:63-71. 1994
    ..5 gm/kg/hr. During hypo- or hyperglycemia, resting mean systemic arterial pressure (MSAP) and heart rate did not change significantly. Brain transection at various levels, i.e...
  16. ncbi The crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase II from Sulfolobus solfataricus, a thermophilic enzyme stabilized by intramolecular disulfide bonds
    Yan Zhang
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853 1301, USA
    J Mol Biol 357:252-62. 2006
    ....
  17. ncbi Genetic and DNA-methylation changes induced by potassium dichromate in Brassica napus L
    Massimo Labra
    Dipartimento di Scienze dell Ambiente e del Territorio, Universita degli Studi di Milano Bicocca, Piazza della Scienza 1, 20126 Milano, Italy
    Chemosphere 54:1049-58. 2004
    ..using a monoclonal antibody against 5-methylcytosine; and (ii) methylation-sensitive amplified polymorphism (MSAP). Immunolabelling showed cytosine-hypermethylation in the Brassica napus L...
  18. ncbi A novel hyperthermostable 5'-deoxy-5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus
    Giovanna Cacciapuoti
    Dipartimento di Biochimica e Biofisica F Cedrangolo, Seconda Universita di Napoli, Italy
    FEBS J 272:1886-99. 2005
    ....
  19. doi Comparison of cerebral glucose metabolism between multiple system atrophy Parkinsonian type and Parkinson's disease
    Tao Feng
    Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Neurol Res 30:377-82. 2008
    ..To investigate the difference in the regional cerebral glucose metabolism between multiple system atrophy Parkinsonian type (MSA-P) and Parkinson's disease (PD)...
  20. doi Construction of methylation linkage map based on MSAP and SSR markers in Sorghum bicolor (L.)
    Yonghong Duan
    Institute of Biotechnology, Shanxi University, Taiyuan, China
    IUBMB Life 61:663-9. 2009
    ..a F2 population derived from a cross of B(2)V(4) x 1383-2 based on methylation-sensitive amplified polymorphism (MSAP) and simple sequence repeats (SSR) markers...
  21. ncbi Tumor suppressor gene alterations of spontaneously malignant transformed cells from human embryonic muscle in vitro
    Xianyao Wang
    Central Laboratory, Chaozhou Central Hospital, Chaozhou 521021, PR China
    Oncol Rep 24:555-61. 2010
    ..several tumor suppressor genes of these cell lines, and homozygous deletions within chromosomal band 9p2l including MTAP (methylthioadenosine phosphorylase), p16 and p15 were detected...
  22. pmc Extensions to the Speech Disorders Classification System (SDCS)
    Lawrence D Shriberg
    Waisman Center, University of Wisconsin Madison, Madison, WI, USA
    Clin Linguist Phon 24:795-824. 2010
    ..Part II describes the Madison Speech Assessment Protocol (MSAP), an ∼ 2-hour battery of 25 measures that includes 15 speech tests and tasks...
  23. ncbi Methylthioadenosine phosphorylase as target for chemoselective treatment of T-cell acute lymphoblastic leukemic cells
    Thomas Efferth
    Virtual Campus Rhineland Palatinate, Mainz, Germany
    Blood Cells Mol Dis 28:47-56. 2002
    We analyzed the role of methylthioadenosine phosphorylase (MTAP) for chemoselective treatment of T-cell acute lymphoblastic leukemia (T-ALL)...
  24. doi Alterations in cytosine methylation and species-specific transcription induced by interspecific hybridization between Oryza sativa and O. officinalis
    Huajun Jin
    Key Laboratory of Ministry of Education for Plant Development Biology, College of Life Sciences, Wuhan University, 430072, Wuhan, China
    Theor Appl Genet 117:1271-9. 2008
    ..In this study, we used the methylation-sensitive amplified polymorphism (MSAP) method to survey cytosine methylation alterations that occurred in F(1) hybrid and BC(1) progeny following ..
  25. doi Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma
    Josh Sommer
    Chordoma Foundation, Greensboro, NC, USA, and Division of Medical Oncology, Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC, USA
    J Pathol 220:608-17. 2010
    ..Another gene in this region, methylthioadenosine phosphorylase (MTAP), is an essential enzyme of the purine salvage pathway and has therapeutic relevance because MTAP-deficient cells ..
  26. ncbi Prevention of thromboxane A2 receptor-mediated pulmonary hypertension by a nonpeptide angiotensin II type 1 receptor antagonist
    F Bertolino
    Division of Cardiovascular Diseases II, Centre de Recherche Pierre Fabre, Castres, France
    J Pharmacol Exp Ther 268:747-52. 1994
    ..In anesthetized, open chest rats, U-46619 dose dependently increased MPAP whereas MSAP presented a biphasic evolution. The U-446619 (1.25 micrograms/kg)-increased MPAP (52.4 +/- 12.1%; P < ...
  27. doi The allotetraploid Arabidopsis thaliana-Arabidopsis lyrata subsp. petraea as an alternative model system for the study of polyploidy in plants
    Julien Beaulieu
    Departement de Phytologie, Universite Laval, 1243 Pavillon C E Marchand, Quebec, QC, G1K 7P4, Canada
    Mol Genet Genomics 281:421-35. 2009
    ..Changes in the degree of methylation were observed at almost 25% of the loci examined by MSAP analysis...
  28. doi Genetic and epigenetic instability of amplification-prone sequences of a novel B chromosome induced by tissue culture in Plantago lagopus L
    Gurmeet Kour
    Plant Genomics Laboratory, School of Biotechnology, University of Jammu, Jammu 180006, India
    Plant Cell Rep 28:1857-67. 2009
    ..and epigenetic mechanisms were assessed in regenerants using molecular techniques, namely, PCR-RFLP, SSAP and MSAP. The retrotransposon-based molecular markers were applied to detect the polymorphism within transposable elements ..
  29. ncbi Expression of methylthioadenosine phosphorylase cDNA in p16-, MTAP- malignant cells: restoration of methylthioadenosine phosphorylase-dependent salvage pathways and alterations of sensitivity to inhibitors of purine de novo synthesis
    Z H Chen
    Cancer Center, University of Massachusetts Medical Center, Worcester, Massachusetts 01655, USA
    Mol Pharmacol 52:903-11. 1997
    5'-Deoxy-5'-methylthioadenosine phosphorylase (MTAP) is involved in the salvage of adenine and methylthio moieties of 5'-deoxy-5'-methylthioadenosine, a byproduct of polyamine synthesis, to adenine nucleotides and methionine, respectively...
  30. ncbi Conformational changes and stabilization induced by phosphate binding to 5'-methylthioadenosine phosphorylase from the thermophilic archaeon Sulfolobus solfataricus
    G Cacciapuoti
    Dipartimento di Biochimica e Biofisica F Cedrangolo, Seconda Universita degli Studi di Napoli, Via Costantinopoli 16, 80138, Naples, Italy
    Extremophiles 5:295-302. 2001
    ....
  31. ncbi Nitric oxide produces different actions in different areas of the periaqueductal grey in cats
    M R Wang
    Graduate Institute of Life Science, National Defense Medical Center, Taiwan, Republic of, Taipei, China
    Neurosci Lett 309:57-61. 2001
    ..the midbrain elicited similar patterns of cardiovascular responses: increases in mean systemic arterial pressure (MSAP), heart rate (HR) and mean blood flows (F) of the common carotid and femoral arteries, accompanied with a 'hissing-..
  32. ncbi [Analysis of genomic DNA methylation level in radish under cadmium stress by methylation-sensitive amplified polymorphism technique]
    Jin Lan Yang
    National Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Horticulture, Nanjing Agricultural University, Nanjing 210095, China
    Zhi Wu Sheng Li Yu Fen Zi Sheng Wu Xue Xue Bao 33:219-26. 2007
    ..genome was analysed using the technique of methylation-sensitive amplified polymorphism (MSAP)...
  33. doi Epigenetic differentiation and relationship to adaptive genetic divergence in discrete populations of the violet Viola cazorlensis
    Carlos M Herrera
    Estacion Biologica de Donana, Consejo Superior de Investigaciones Cientificas CSIC, Isla de la Cartuja, Sevilla, Spain
    New Phytol 187:867-76. 2010
    ..the southern Spanish violet Viola cazorlensis (Violaceae) using the methylation-sensitive amplified polymorphism (MSAP) technique, a modification of the amplified fragment length polymorphism method (AFLP) based on the differential ..
  34. doi Prenatal exposure to zymosan results in hypertension in adult offspring rats
    Wenqiang Liao
    National Integrative Medicine Centre for Cardiovascular Diseases, China Japan Friendship Hospital, Beijing, China
    Clin Exp Pharmacol Physiol 35:1413-8. 2008
    ..a non-infectious and non-bacterial agent capable of inducing inflammation, on mean systolic arterial pressure (MSAP) in rat offspring at 6-66 weeks of age. 2...
  35. pmc Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma
    Yuwaraj Kadariya
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 69:5961-9. 2009
    Large homozygous deletions of 9p21 that inactivate CDKN2A, ARF, and MTAP are common in a wide variety of human cancers...
  36. ncbi Tissue culture-induced locus-specific alteration in DNA methylation and its correlation with genetic variation in Codonopsis lanceolata Benth. et Hook. f
    W L Guo
    Laboratory of Plant Molecular Epigenetics, Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China
    Plant Cell Rep 26:1297-307. 2007
    ..of cytosine methylation at the CCGG sites in the same set of regenerants relative to the donor plant, by the MSAP method employing a pair of isoschizomers, HpaII and MspI, which recognize the same restriction site but are ..
  37. ncbi Detection of stool DNA mutations before and after treatment of colorectal neoplasia
    Sapna Syngal
    Division of Population Sciences, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer 106:277-83. 2006
    ....
  38. ncbi Using specific cytotoxics with a targeted mind
    Angelo Di Leo
    Sandro Pitigliani Medical Oncology Unit, Department of Oncology, Hospital of Prato, Tuscany Cancer Institute, Prato, Italy
    Breast 16:S120-6. 2007
    ..b) Taxanes Microtubule-associated parameters (MTAP) such as the TAU protein, HER-2 gene amplification, and p-53 gene mutations, have been suggested as potential ..
  39. pmc Design and synthesis of potent "sulfur-free" transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylase
    Alistair I Longshaw
    Carbohydrate Chemistry Team, Industrial Research Limited, P O Box 31310, Lower Hutt, New Zealand
    J Med Chem 53:6730-46. 2010
    ..In humans, 5'-methylthioadenosine phosphorylase (MTAP) is involved in polyamine biosynthesis as well as in purine and SAM salvage pathways and thus has been identified ..
  40. doi Alteration of DNA methylation level and pattern in sorghum (Sorghum bicolor L.) pure-lines and inter-line F1 hybrids following low-dose laser irradiation
    Huan Wang
    Key Laboratory of Molecular Epigenetics of MOE, Northeast Normal University, Changchun 130024, China
    J Photochem Photobiol B 99:150-3. 2010
    ..level and pattern of DNA methylation in the plants were analyzed by methylation-sensitive amplified polymorphism (MSAP)...
  41. ncbi Extent and pattern of DNA methylation alteration in rice lines derived from introgressive hybridization of rice and Zizania latifolia Griseb
    Z Y Dong
    Laboratory of Plant Molecular Epigenetics, Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China
    Theor Appl Genet 113:196-205. 2006
    ..In this study, using the methylation-sensitive amplified polymorphism (MSAP) method, we globally assessed the extent and pattern of cytosine methylation alterations in three typical ..
  42. ncbi Sensitivity and specificity of a stool DNA multitarget assay panel for the detection of advanced colorectal neoplasia
    Kuldeep S Tagore
    University of California Davis Medical Center, Sacramento, USA
    Clin Colorectal Cancer 3:47-53. 2003
    ..This study was designed to provide an estimate of the sensitivity and specificity of a multitarget assay panel (MTAP) of stool DNA changes...
  43. ncbi Circadian pharmacology of L-alanosine (SDX-102) in mice
    Xiao Mei Li
    Institut National de la Sante et de la Recherche Medicale, U776 Rythmes biologiques et cancers Université Paris Sud, Paul Brousse Hospital, 94800 Villejuif, France
    Mol Cancer Ther 5:337-46. 2006
    ..through inhibition of de novo purine biosynthesis, an effect potentiated by methylthioadenosine phosphorylase (MTAP) deficiency. The relevance of circadian dosing time was investigated for chronotherapeutic optimization of SDX-102...
  44. ncbi Genomic instability in Solanum tuberosum x Solanum kurtzianum interspecific hybrids
    C F Marfil
    Laboratorio de Biologia Molecular, INTA La Consulta, CONICET, Facultad de Ciencias Agrarias, U N de Cuyo, A Brown 500 M5528AHB Chacras de Coria, Mendoza, Argentina
    Genome 49:104-13. 2006
    ..Of 277 MSAP fragments analyzed, 14% showed methylation patterns that differed between the parental species and the hybrids...
  45. ncbi [DNA methylation in cotton hybrids and their parents]
    Y Zhao
    Mol Biol (Mosk) 42:195-205. 2008
    ..methylation level from seedling stage to flowering stage by using the methylation-sensitive amplified polymorphism (MSAP) method...
  46. ncbi Concordant loss of MTAP and p16/CDKN2A expression in gastroesophageal carcinogenesis: evidence of homozygous deletion in esophageal noninvasive precursor lesions and therapeutic implications
    Eric L Powell
    Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
    Am J Surg Pathol 29:1497-504. 2005
    The gene that encodes methylthioadenosine phosphorylase (MTAP), an enzyme involved in adenine and methionine salvage pathways, is located on chromosome 9p21 telomeric to the p16INK4A/CDKN2A tumor suppressor gene...
  47. doi Diffusion tensor imaging in idiopathic Parkinson's disease and multisystem atrophy (parkinsonian type)
    Christian Daniel Cnyrim
    Department of Neuroradiology, UK SH, Kiel, Germany
    Neurodegener Dis 13:1-8. 2014
    ..FA) within white brain matter between patients with PD and multisystem atrophy of the parkinsonian type (MSAp)...
  48. ncbi Genetic identity of clones and methods to explore DNA
    B de Montera
    Unité de Biologie du Développement et Reproduction, INRA, Jouy en Josas, France
    Cloning Stem Cells 6:133-9. 2004
    ..We have used, in parallel, the AFLP technique (amplification fragment length polymorphism) and one of its variant, MSAP (methylation-sensitive amplification polymorphism)...
  49. ncbi Chemotherapy targeting methylthioadenosine phosphorylase (MTAP) deficiency in adult T cell leukemia (ATL)
    H Harasawa
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Leukemia 16:1799-807. 2002
    Methylthioadenosine phosphorylase (MTAP) is an important enzyme used for the salvage of adenine and methionine. Cells lacking this enzyme are expected to be sensitive to purine synthesis inhibitors and/or methionine starvation...
  50. ncbi Acute cardiopulmonary effects of a dual-endothelin receptor antagonist on oleic acid-induced pulmonary arterial hypertension in dogs
    Ling Wang
    Research Institute of Respiratory Diseases and Department of Surgical Intensive Care Unit, Zhongshan Hospital, Fudan University, Shanghai, China
    Exp Lung Res 30:31-42. 2004
    ..arterial pressure (MPAP) and pulmonary vascular resistance (PVR) and a decrease in mean systemic arterial pressure (MSAP), systemic vascular resistance (SVR), and cardiac output (CO) in all dogs...
  51. pmc Transgenerational variations in DNA methylation induced by drought stress in two rice varieties with distinguished difference to drought resistance
    Xiaoguo Zheng
    College of Plant Sciences and Technology, Huazhong Agricultural University, Wuhan, China Shanghai Agrobiological Gene Center, Shanghai, China
    PLoS ONE 8:e80253. 2013
    ..drought stress (DT) at seedling stage were assessed by using Methylation Sensitive Amplification Polymorphism (MSAP) method...
  52. pmc Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice
    Juyong Brian Kim
    Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1679, USA
    Circulation 126:1896-906. 2012
    ..We set out to investigate the potential role of the 9p21.3 locus neighboring genes, including Mtap, the 2 isoforms of Cdkn2a, p16Ink4a and p19Arf, and Cdkn2b, in atherosclerosis using knockout mice models.
  53. doi Rapid alterations of gene expression and cytosine methylation in newly synthesized Brassica napus allopolyploids
    Yanhao Xu
    College of Life Sciences, Wuhan University, Wuhan, 430072, China
    Planta 229:471-83. 2009
    ..Using cDNA-amplified fragment length polymorphism (cDNA-AFLP) and methylation-sensitive amplification polymorphism (MSAP) approaches, ~4.09 and 6...
  54. doi Quantification of intermediates of the methionine and polyamine metabolism by liquid chromatography-tandem mass spectrometry in cultured tumor cells and liver biopsies
    Axel P Stevens
    Institute of Functional Genomics, University of Regensburg, Josef Engert Str 9, 93053 Regensburg, Germany
    J Chromatogr A 1217:3282-8. 2010
    ..we showed recently, that the chromosomal deletion or inactivation of the methylthioadenosine phosphorylase (MTAP) gene led to the accumulation of 5'-deoxy-5'-(methylthio)adenosine (MTA) in cancer cells...
  55. doi Analysis of DNA methylation in different maize tissues
    Yanli Lu
    Maize Research Institute of Sichuan Agriculture University Key Laboratory of Crop Genetic Resource and Improvement, Ministry of Education, Ya an, China
    J Genet Genomics 35:41-8. 2008
    ..Both MSAP (methylation sensitive amplification polymorphism) ratio and full methylation level were the highest in bracteal ..
  56. ncbi Analysis of ploidy and the patterns of amplified fragment length polymorphism and methylation sensitive amplified polymorphism in strawberry plants recovered from cryopreservation
    Yu Jin Hao
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, P R China
    Cryo Letters 23:37-46. 2002
    ..Methylation sensitive amplified polymorphism (MSAP) assay was carried out for further investigation on the influence of cryopreservation on DNA methylation status...
  57. pmc Multimodal interventional molecular imaging of tumor margins and distant metastases by targeting αvβ3 integrin
    Anton Bunschoten
    Interventional Molecular Imaging, Department of Radiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Chembiochem 13:1039-45. 2012
    ..A hybrid imaging agent targeting the α(v)β(3) integrin--(111)In-MSAP-RGD (MSAP = multifunctional single-attachment-point reagent), which contains a targeting moiety, a pentetic acid (..
  58. pmc Inter-species grafting caused extensive and heritable alterations of DNA methylation in Solanaceae plants
    Rui Wu
    Key Laboratory of Molecular Epigenetics of Ministry of Education MOE, Northeast Normal University, Changchun, Jilin Province, China
    PLoS ONE 8:e61995. 2013
    ..Given characteristics of grafting, it is interesting to test whether the process may cause an alteration of this epigenetic marker in the grafted organismal products...
  59. pmc Common genetic variants in the 9p21 region and their associations with multiple tumours
    F Gu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
    Br J Cancer 108:1378-86. 2013
    ..The chromosome 9p21.3 region has been implicated in the pathogenesis of multiple cancers...
  60. doi Spaceflight-induced genetic and epigenetic changes in the rice (Oryza sativa L.) genome are independent of each other
    Xiufang Ou
    Key Laboratory of Molecular Epigenetics of MOE and Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China
    Genome 53:524-32. 2010
    ..of DNA markers, amplified fragment length polymorphism (AFLP) and methylation sensitive amplified polymorphism (MSAP)...
  61. ncbi Methylthioadenosine phosphorylase expression in cutaneous squamous cell carcinoma
    Hasen M Alhebshi
    Institute of Medicine, University of Brunei Darussalam, Jalan Tungku Link, Gadong BE1410, Brunei Darussalam
    Asian Pac J Cancer Prev 9:291-4. 2008
    The methylthioadenosine phosphorylase (MTAP) gene is a tumour suppressor gene, located on chromosome 9p21, 100 kb telomeric of the p15 and p16 genes, which are often deleted in tumor cells...
  62. ncbi The methylthioadenosine phosphorylase gene is frequently co-deleted with the p16INK4a gene in acute type adult T-cell leukemia
    Y Hori
    Department of Medicine, Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla, USA
    Int J Cancer 75:51-6. 1998
    ..The gene for methylthioadenosine phosphorylase (MTAP), a purine and methionine metabolic enzyme, resides approximately 100 Kb telomeric to the p16INK4a gene and is ..
  63. doi Incidence and prevalence of multiple system atrophy: a nationwide study in Iceland
    Anna Björnsdóttir
    Department of Neurology, Landspitali University Hospital, Fossvogur, Reykjavik 108, Iceland
    J Neurol Neurosurg Psychiatry 84:136-40. 2013
    ..system atrophy (MSA) is a neurodegenerative disorder characterised by autonomic dysfunction with parkinsonism (MSAp) or cerebellar (MSAc) symptoms...
  64. pmc General-purpose genotype or how epigenetics extend the flexibility of a genotype
    Rachel Massicotte
    Departement de sciences biologiques, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, QC, Canada H3C 3J7
    Genet Res Int 2012:317175. 2012
    ..In spite of a low number of informative fragments obtained from an MSAP analysis, individuals of a given lake are epigenetically similar, and methylation profiles allow the clustering of ..
  65. doi Role of disulfide bonds in conformational stability and folding of 5'-deoxy-5'-methylthioadenosine phosphorylase II from the hyperthermophilic archaeon Sulfolobus solfataricus
    Giovanna Cacciapuoti
    Dipartimento di Biochimica e Biofisica F Cedrangolo, Seconda Universita di Napoli, Via Costantinopoli 16, 80138 Napoli, Italy
    Biochim Biophys Acta 1824:1136-43. 2012
    ..Thermal and chemical unfolding of SsMTAPII occur with dissociation of the native hexameric state into denatured monomers, as indicated by SDS-PAGE...
  66. pmc Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells
    Baiqing Tang
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA
    Cancer Biol Ther 13:1082-90. 2012
    Methylthioadenosine phosphorylase (MTAP), a key enzyme in the catabolism of 5'-deoxy-5'-methylthioadenosine (MTA), catalyzes the formation of adenine and 5-methylthioribose-1-phosphate...
  67. doi Homozygous deletion of MTAP gene as a poor prognosticator in gastrointestinal stromal tumors
    Hsuan Ying Huang
    Departments of Pathology, Surgery, and Radiation Oncology, and Divisions of Oncology and Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Clin Cancer Res 15:6963-72. 2009
    ..We did an integrative study of MTAP gene at 9p21 to analyze its implication in GISTs.
  68. doi Changes of cytosine methylation induced by wide hybridization and allopolyploidy in Cucumis
    Longzheng Chen
    State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Horticulture, Nanjing Agricultural University, Nanjing 210095, China
    Genome 51:789-99. 2008
    ..phenomena, we investigated cytosine methylation in Cucumis by using methylation-sensitive amplified polymorphism (MSAP)...
  69. ncbi Search for methylation-sensitive amplification polymorphisms associated with the mantled variant phenotype in oil palm (Elaeis guineensis Jacq)
    E Jaligot
    UMR 1098 Biologie du Dévelopment des Espèces Pèrennes Cultivées, CIRAD CP IRD, Centre IRD, Montpellier, France
    Genome 47:224-8. 2004
    The methylation-sensitive amplification polymorphism (MSAP) technique has been employed on somatic embryo-derived oil palms (Elaeis guineensis Jacq.) to identify methylation polymorphisms correlated with the "mantled" somaclonal variation...
  70. doi Moderately severe acute pancreatitis: prospective validation of this new subgroup of acute pancreatitis
    Rupjyoti Talukdar
    Mayo Clinic College of Medicine, Rochester, MN, USA
    Pancreas 41:306-9. 2012
    We described the entity moderately severe acute pancreatitis (MSAP), characterized by local complications (LCs) without organ failure (OF). The aim of this study was to validate MSAP.
  71. ncbi SATR-1 hypomethylation is a common and early event in breast cancer
    Fabricio F Costa
    Laboratory of Molecular Biology and Genomics, Ludwig Institute for Cancer Research, Rua Prof Antonio Prudente, 109, 4th Floor, 01509 010 Sao Paulo, SP Brazil
    Cancer Genet Cytogenet 165:135-43. 2006
    ..In this work, we used methylation-sensitive arbitrarily primed polymerase chain reaction (MSAP-PCR) to identify differentially methylated DNA fragments in normal and tumor breast samples...
  72. ncbi Reliability and validity of a new computer-administered pictorial activity and task sort
    John Mayer
    US Spine and Sport Foundation, 3444 Kearny Villa Road, Suite 307, San Diego, California, USA
    J Occup Rehabil 15:203-13. 2005
    ..The Multidimensional Task Ability Profile (MTAP) is the latest in a series of measures that use a combination of drawings and task descriptions in a self-report ..
  73. ncbi Implications of P16/CDKN2A deletion in pleural mesotheliomas
    Marc Ladanyi
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Lung Cancer 49:S95-8. 2005
    ..The homozygous co-deletion of MTAP, encoding the enzyme methylthioadenosine phosphorylase, in approximately 90% of mesotheliomas with P16/CDKN2A loss ..
  74. pmc Regulation of human methylthioadenosine phosphorylase gene by the CBF (CCAAT binding factor)/NF-Y (nuclear factor-Y)
    Yuwaraj Kadariya
    Department of Laboratory Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Biochem J 387:175-83. 2005
    ..To understand the mechanism of the transcriptional regulation of the MTAP gene, we have cloned the 1...
  75. ncbi Methylthioadenosine phosphorylase from the archaeon Pyrococcus furiosus. Mechanism of the reaction and assignment of disulfide bonds
    Giovanna Cacciapuoti
    Dipartimento di Biochimica e Biofisica F Cedrangolo, Seconda Universita di Napoli, Naples, Italy
    Eur J Biochem 271:4834-44. 2004
    ....
  76. pmc Increased sensitivity to thiopurines in methylthioadenosine phosphorylase-deleted cancers
    Sally A Coulthard
    Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Paul O Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Mol Cancer Ther 10:495-504. 2011
    ..The toxicity of DNPS inhibitors is influenced by methylthioadenosine phosphorylase (MTAP), a gene frequently deleted in cancers...
  77. pmc DNA methylation polymorphism in flue-cured tobacco and candidate markers for tobacco mosaic virus resistance
    Jie hong Zhao
    Guizhou Institute of Tobacco Science, Guiyang 550081, China
    J Zhejiang Univ Sci B 12:935-42. 2011
    ..of allotetraploid flue-cured tobacco, Nicotiana tabacum, using a methylation-sensitive amplified polymorphism (MSAP) technique. The results showed that methylation existed at a high level among tobacco accessions, among which 49...
  78. pmc Characterization of the genetic components of Streptomyces lividans linear plasmid SLP2 for replication in circular and linear modes
    Mingxuan Xu
    Shanghai Institute of Plant Physiology, Shanghai Institutes of Biological Sciences, The Chinese Academy of Sciences, 300 Fenglin Road, Shanghai, 200032 People s Republic of China
    J Bacteriol 188:6851-7. 2006
    ..To replicate SLP2 in linear mode, additional SLP2 loci--either mtap(SLP2)/tpg(SLP2) or mtap(SLP2)/ilrA(SLP2)--were required...
  79. doi Analysis of target sequences of DDM1s in Brassica rapa by MSAP
    Taku Sasaki
    Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai, Miyagi, 981 8555, Japan
    Plant Cell Rep 30:81-8. 2011
    ..level between a wild-type (WT) plant and a ddm1-RNAi plant by methylation-sensitive amplification polymorphism (MSAP) analysis. MSAP analysis detected changes of DNA methylation of many repetitive sequences in the ddm1-RNAi plant...
  80. doi Jack of all nectars, master of most: DNA methylation and the epigenetic basis of niche width in a flower-living yeast
    C M Herrera
    Estacion Biologica de Donana, Consejo Superior de Investigaciones Cientificas CSIC, Avenida Americo Vespucio s n, Isla de la Cartuja, 41092 Sevilla, Spain
    Mol Ecol 21:2602-16. 2012
    ..reukaufii in the wild were combined with laboratory experiments and methylation-sensitive amplified polymorphism (MSAP) analyses designed to detect epigenetic responses of single genotypes to variations in sugar environment that ..
  81. pmc Next generation sequencing of prostate cancer from a patient identifies a deficiency of methylthioadenosine phosphorylase, an exploitable tumor target
    Colin C Collins
    Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Mol Cancer Ther 11:775-83. 2012
    ..Both tumor and xenograft had a homozygous 9p21 deletion spanning the MTAP, CDKN2, and ARF genes...
  82. doi A corrected space group for Sulfolobus sulfataricus 5'-deoxy-5'-methylthioadenosine phosphorylase II
    Yang Zhang
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853 1301, USA
    Acta Crystallogr D Biol Crystallogr 68:249-52. 2012
    5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) catalyzes the phosphorolytic cleavage of 5'-deoxy-5'-methylthioadenosine (MTA), a byproduct of polyamine biosynthesis. The Sulfolobus sulfataricus genome encodes two MTAPs...
  83. pmc Primate genome gain and loss: a bone dysplasia, muscular dystrophy, and bone cancer syndrome resulting from mutated retroviral-derived MTAP transcripts
    Olga Camacho-Vanegas
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Hum Genet 90:614-27. 2012
    ..proximal of three previously uncharacterized terminal exons of the gene encoding methylthioadenosine phosphorylase, MTAP. Intriguingly, two of these MTAP exons arose from early and independent retroviral-integration events in primate ..
  84. doi Direct and indirect organogenesis of Clivia miniata and assessment of DNA methylation changes in various regenerated plantlets
    Qin Mei Wang
    Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, People s Republic of China
    Plant Cell Rep 31:1283-96. 2012
    ..We employed the methylation-sensitive amplified polymorphism (MSAP) method to assess cytosine methylation variation in various regenerated plantlets and between organs...
  85. ncbi [Di-(2-ethylhexyl) phthalate increases the DNA methylation level of genomes in the mouse testis]
    Sheng De Wu
    Department of Urology, Children s Hospital of Chongqing Medical University, Chongqing 400014, China
    Zhonghua Nan Ke Xue 15:876-81. 2009
    ..To investigate the effect of the exposure to di- (2-ethylhexyl) phthalate (DEHP) during pregnancy on the DNA methylation level of genomes in the testis of the offspring in mice...
  86. pmc Divergent oriented synthesis for the design of reagents for protein conjugation
    Elisabeth Garanger
    Laboratoire de Chimie des Polymeres Organiques LCPO, UMR 5629 CNRS, IPB ENSCBP, Universite Bordeaux I, Pessac Cedex, France
    J Comb Chem 12:57-64. 2010
    ..biological activities, we employed the DOS method to efficiently obtain multifunctional single attachment point (MSAP) reagents for the conjugation to proteins...
  87. doi Comprehensive field synopsis and systematic meta-analyses of genetic association studies in cutaneous melanoma
    Foteini Chatzinasiou
    Department of Dermatology, University of Athens Medical School, Andreas Sygros Hospital, Dragoumi 5, Athens 161 21, Greece
    J Natl Cancer Inst 103:1227-35. 2011
    ....
  88. doi Untangling individual variation in natural populations: ecological, genetic and epigenetic correlates of long-term inequality in herbivory
    C M Herrera
    Estacion Biologica de Donana, Consejo Superior de Investigaciones Cientificas, Avenida Americo Vespucio s n, Isla de la Cartuja, Sevilla 41092, Spain
    Mol Ecol 20:1675-88. 2011
    ..In addition, methylation-sensitive amplified polymorphism (MSAP) analyses were used to investigate the association between browsing damage and epigenetic characteristics of ..
  89. ncbi Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia
    O I Olopade
    Department of Medicine, University of Chicago, Illinois 60637
    Genomics 14:437-43. 1992
    ..IFNW), and-beta-1 (IFNB1) interferon genes, as well as the gene for the enzyme methylthioadenosine phosphorylase (MTAP)...
  90. doi Snapshot of DNA methylation changes associated with hybridization in Xenopus
    Alie Patrick Koroma
    Biology Department, University of Texas at Arlington, Arlington, Texas, USA
    Physiol Genomics 43:1276-80. 2011
    ..laevis and X. muelleri, using methyl-sensitive amplification polymorphisms (MSAPs). Out of a total of 546 MSAP markers, 364 were effective in elucidating the difference in methylation patterns between the hybrids and the ..
  91. doi Downregulation of methylthioadenosin phosphorylase by homozygous deletion in gastric carcinoma
    Jin Kim
    Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Genes Chromosomes Cancer 50:421-33. 2011
    The methylthioadenosine phosphorylase (MTAP) gene is located on 9p21 telomeric to the CDKN2A tumor suppressor gene. Loss of MTAP gene is frequently associated with CDKN2A homozygous deletion...
  92. doi Focal 9p instability in hematologic neoplasias revealed by comparative genomic hybridization and single-nucleotide polymorphism microarray analyses
    Anu Usvasalo
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Genes Chromosomes Cancer 49:309-18. 2010
    ..Other possibly important genes included MTAP, IFN, MLLT3, JAK2, PTPLAD2, and PAX5...
  93. pmc Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma
    Caroline Conway
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds, UK
    Genes Chromosomes Cancer 49:425-38. 2010
    ..3 including the genes CDKN2A (which encodes CDKN2A and P14ARF), CDKN2B (CDKN2B), and MTAP was measured using multiplexed ligation-dependant probe amplification (MLPA), (N = 75 results)...
  94. ncbi [Effect of napthalene on the DNA methylation patterns and level in rice (Oryza sativa L.)]
    Jian cheng Fan
    College of Urban and Environmental Sciences, Northeast Normal University, Changchun 130024, China
    Huan Jing Ke Xue 31:793-800. 2010
    ..Epigenetic instabilities in the blade of the plants in tillering and heading stage were assessed by MSAP marks...
  95. doi The Motif Tool Assessment Platform (MTAP) for sequence-based transcription factor binding site prediction tools
    Daniel Quest
    Computational Biology Group, Biological Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, USA
    Methods Mol Biol 674:121-41. 2010
    ..In this chapter, a novel and robust assessment tool, the Motif Tool Assessment Platform (MTAP), is introduced and discussed.
  96. doi Potato cytosine methylation and gene expression changes induced by a beneficial bacterial endophyte, Burkholderia phytofirmans strain PsJN
    Kedong Da
    Institute for Sustainable and Renewable Resources, Institute for Advanced Learning and Research, 150 Slayton Avenue, Danville, VA 24540, USA
    Plant Physiol Biochem 50:24-34. 2012
    ..used a combination of capillary electrophoresis and methylation-sensitive amplification length polymorphism (CE-MSAP) analysis to investigate the potato genomic DNA cytosine methylation changes that occur in response to PsJN ..
  97. ncbi [Macrocystic serous adenoma of the pancreas: a report of 5 cases]
    Yan Liang Wang
    Department of Pancreatic and Gastroenterologic Surgery, The First Affiliated Hospital, China Medical University, Shenyang, China
    Zhonghua Wai Ke Za Zhi 48:1405-8. 2010
    To investigate the diagnosis and treatment of macrocystic serous adenoma of the pancreas (MSAP).
  98. doi Unraveling the structural and functional differences between purine nucleoside phosphorylase and 5'-deoxy-5'-methylthioadenosine phosphorylase from the archaeon Pyrococcus furiosus
    Giovanna Cacciapuoti
    Dipartimento di Biochimica e Biofisica F Cedrangolo, Seconda Universita di Napoli, Via Costantinopoli 16, Napoli, Italy
    Biochim Biophys Acta 1814:1358-66. 2011
    ..Finally, we utilized the structural models of mutant enzyme-substrate complex to rationalize the functional effects of the mutations...
  99. pmc Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: current strategies
    Joseph R Bertino
    Departments of Medicine and Pharmacology, The Cancer Institute of NJ, Robert Wood Johnson Medical School, New Brunswick, USA
    Cancer Biol Ther 11:627-32. 2011
    Many solid tumors and hematologic malignancies lack expression of the enzyme methylthioadenosine phosphorylase (MTAP), due either to deletion of the MTAP gene or to methylation of the MTAP promoter...
  100. pmc Down-regulation of methylthioadenosine phosphorylase (MTAP) induces progression of hepatocellular carcinoma via accumulation of 5'-deoxy-5'-methylthioadenosine (MTA)
    Georgi Kirovski
    Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Am J Pathol 178:1145-52. 2011
    Recently, we have shown that down-regulation of methylthioadenosine phosphorylase (MTAP) in hepatocellular carcinoma (HCC) cells enhances the invasive potential and the resistance against cytokines...
  101. doi Expression of Chr9p21 genes CDKN2B (p15(INK4b)), CDKN2A (p16(INK4a), p14(ARF)) and MTAP in human atherosclerotic plaque
    Lesca Miriam Holdt
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Leipzig, Leipzig, Germany
    Atherosclerosis 214:264-70. 2011
    ..kinase inhibitors CDKN2B (p15(INK4b)), CDKN2A (p16(INK4a), p14(ARF)) and methylthioadenosine phosphorylase (MTAP) were expressed in human atherosclerotic lesions and whether expression was correlated with lesion composition.

Research Grants74

  1. Purine Pathways and Inhibitor Design in Plasmodium
    Vern Schramm; Fiscal Year: 2006
    ..in gene-disruptions of purine nucleoside phosphorylase (PNP), HGXPRT, APRT, and methylthioadenosine phosphorylase (MTAP). The hypothesis is that PNP and HGXPRT form the dominant purine salvage pathway...
  2. Purine salvage as a chemotherapeutic target in malaria
    Kami Kim; Fiscal Year: 2002
    ..The significance of alternative purine salvage enzymes methylthioadenosine phosphorylase (MTAP) and adenine phosphoribosyltransferase (APRT) will be examined using genetic disruption and inhibitor ablation of ..
  3. Transition State Analogues as Modulators of DNA Methylation
    Vern L Schramm; Fiscal Year: 2010
    ..is an orally available transition state analogue inhibitor for human 5'- methylthioadenosine phosphorylase (MTAP)...
  4. Colon Polyp Surveillance with DNA Analysis of Stool
    Philip Schoenfeld; Fiscal Year: 2002
    ..Multi-target DNA-based assay panels (MTAP) of stool may accurately diagnose colon adenomas...
  5. The Role of Methylthioadenosine Phosphorylase Loss in Tumorigenesis
    Warren D Kruger; Fiscal Year: 2010
    Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine salvage pathway whose function is to convert 5cent-deoxy-5cent-methylthioadenosine (MTA) into methionine...
  6. Reagents for the Design of Targeted Multifunctional Nanomaterials
    Lee Josephson; Fiscal Year: 2010
    ..multifunctional materials design lies in a new class of reagents termed Multifunctional Single Attachment Point or MSAP's...
  7. MECHANISM OF ACTION OF FOLATE ANTAGONISTS
    Joseph Bertino; Fiscal Year: 2003
    ....
  8. Mechanism of Action of Folate Antagonist
    Joseph Bertino; Fiscal Year: 2007
    ..The use of MEF cells null for p53, p19 ARF and both will be utilized to test in a more well defined system the function of these proteins on DHFR levels. ..
  9. Mechanism of Action of Folate Antagonist
    Joseph Bertino; Fiscal Year: 2007
    ..The use of MEF cells null for p53, p19 ARF and both will be utilized to test in a more well defined system the function of these proteins on DHFR levels. ..
  10. CANCER CENTER SUPPORT GRANT
    Joseph Bertino; Fiscal Year: 2007
    ..abstract_text> ..
  11. DEVELOPMENTAL PHONOLOGICAL DISORDERS
    Lawrence D Shriberg; Fiscal Year: 2010
    ..A translational project will provide speech-language pathologists with an assessment tool to make early and accurate diagnostic decisions, with implications for individualized treatment based on the type of speech delay. ..
  12. DEVELOPMENTAL PHONOLOGICAL DISORDERS
    LAWRENCE SHRIBERG; Fiscal Year: 2009
    ..A translational project will provide speech-language pathologists with an assessment tool to make early and accurate diagnostic decisions, with implications for individualized treatment based on the type of speech delay. ..
  13. The TCGA Cancer Genome Characterization Center at MSKCC
    Marc Ladanyi; Fiscal Year: 2007
    ..They will also perform a variety of higher level analyses and integrated analyses to derive prioritized lists of genes and genomic regions of interest for sequencing by the TCGA Genome Sequencing Centers. ..
  14. MOLECULAR MODELING OF DIAGNOSIS AND PROGNOSIS IN HNSCC
    Maria Worsham; Fiscal Year: 2009
    ..abstract_text> ..
  15. BENIGN BREAST DISEASE--MOLECULAR DIFFERENTIATION OF RISK
    Maria Worsham; Fiscal Year: 2001
    ....
  16. ASPL TFE3 fusion in human cancers
    Marc Ladanyi; Fiscal Year: 2006
    ..3->qter; and finally analyze selected candidate genes in the same region for inactivating mutations. ..
  17. INHERITED MSH6 MUTATIONS IN DIVERSE COLORECTAL CANCERS
    Sapna Syngal; Fiscal Year: 2004
    ..Evidence that MSH6 is a moderately penetrant, later-onset hereditary colorectal cancer gene would imply the existence of similar genes for other common cancers that await discovery. ..