Gene Symbol: MT2A
Description: metallothionein 2A
Alias: MT-2, MT-II, MT2, metallothionein-2, metallothionein-II
Species: human
Products:     MT2A

Top Publications

  1. Lim D, Jocelyn K, Yip G, Bay B. Silencing the Metallothionein-2A gene inhibits cell cycle progression from G1- to S-phase involving ATM and cdc25A signaling in breast cancer cells. Cancer Lett. 2009;276:109-17 pubmed publisher
    ..These data suggest that MT-2A could plausibly modulate cell cycle progression from G1- to S-phase via the ATM/Chk2/cdc25A pathway. ..
  2. Kayaalti Z, Soylemezoglu T. The polymorphism of core promoter region on metallothionein 2A-metal binding protein in Turkish population. Mol Biol Rep. 2010;37:185-90 pubmed publisher
    ..3% heterozygote and 0.7% homozygote atypical genotype. The allele frequencies were consistent with Hardy-Weinberg equilibrium (chi(2) = 0.2719; P > 0.05). ..
  3. Garrett S, Sens M, Shukla D, Flores L, Somji S, Todd J, et al. Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer. Prostate. 2000;43:125-35 pubmed
    ..Expression of MT-1X mRNA is downregulated in advanced prostate cancer. Variable expression of MT mRNA in prostate cell lines provides evidence that MT gene expression may be altered among individual prostate cancers. ..
  4. Rao P, Jaggi M, Smith D, Hemstreet G, Balaji K. Metallothionein 2A interacts with the kinase domain of PKCmu in prostate cancer. Biochem Biophys Res Commun. 2003;310:1032-8 pubmed
    ..Because metallothioneins are associated with cell proliferation and CR, the PKCmu-MT 2A interaction may contribute to CR and/or AI in PC. ..
  5. Giacconi R, Cipriano C, Muti E, Costarelli L, Maurizio C, Saba V, et al. Novel -209A/G MT2A polymorphism in old patients with type 2 diabetes and atherosclerosis: relationship with inflammation (IL-6) and zinc. Biogerontology. 2005;6:407-13 pubmed
    ..The aim of the present study is to screen a single nucleotide polymorphism in the promoter region of the MT2A gene in relation to inflammation (IL-6) and plasma zinc in NIDDM-atherosclerotic patients...
  6. Kita K, Miura N, Yoshida M, Yamazaki K, Ohkubo T, Imai Y, et al. Potential effect on cellular response to cadmium of a single-nucleotide A --> G polymorphism in the promoter of the human gene for metallothionein IIA. Hum Genet. 2006;120:553-60 pubmed
    ..These results suggest that the A --> G single-nucleotide polymorphism reduces the efficiency of those aspects of the transcription of the gene for MT-IIA that are controlled by general transcription factors. ..
  7. Giacconi R, Muti E, Malavolta M, Cipriano C, Costarelli L, Bernardini G, et al. The +838 C/G MT2A polymorphism, metals, and the inflammatory/immune response in carotid artery stenosis in elderly people. Mol Med. 2007;13:388-95 pubmed
    ..recent investigation of older patients with diabetes and atherosclerosis showed an association between the -209 A/G MT2A polymorphism, CS, and zinc status...
  8. Wei H, Desouki M, Lin S, Xiao D, Franklin R, Feng P. Differential expression of metallothioneins (MTs) 1, 2, and 3 in response to zinc treatment in human prostate normal and malignant cells and tissues. Mol Cancer. 2008;7:7 pubmed publisher
    ..The results suggest the potential of MT1/2 as a candidate biomarker for prostate cancer and the utilization of zinc in prostate cancer prevention and treatment. ..
  9. Yang L, Li H, Yu T, Zhao H, Cherian M, Cai L, et al. Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications. Am J Physiol Endocrinol Metab. 2008;294:E987-92 pubmed publisher
    ..and rs11076161 in MT1A gene, rs8052334, rs964372, and rs7191779 in MT1B gene, rs708274 in MT1E gene, and rs10636 in MT2A gene) were detected in 851 Chinese people of Han descent (397 diabetes and 454 controls)...

More Information

Publications125 found, 100 shown here

  1. Kayaalti Z, Mergen G, Soylemezoglu T. Effect of metallothionein core promoter region polymorphism on cadmium, zinc and copper levels in autopsy kidney tissues from a Turkish population. Toxicol Appl Pharmacol. 2010;245:252-5 pubmed publisher
    ..The aim of this study was to investigate the association between the -5 A/G metallothionein 2A (MT2A) single nucleotide polymorphism (SNP) and Cd, Zn and Cu levels in the renal cortex from autopsy cases...
  2. McElroy J, Bryda E, McKay S, Schnabel R, Taylor J. Genetic variation at a metallothionein 2A promoter single-nucleotide polymorphism in white and black females in Midwestern United States. J Toxicol Environ Health A. 2010;73:1283-7 pubmed publisher was to determine the frequency of the A and G alleles at rs28366003, which lies in the 5' promoter region of MT2A, in White and Black females in the Midwestern United States...
  3. Kim H, Kim J, Han E, Hwang Y, Choi J, Park B, et al. Metallothionein-2A overexpression increases the expression of matrix metalloproteinase-9 and invasion of breast cancer cells. FEBS Lett. 2011;585:421-8 pubmed publisher
    ..Furthermore, we found that MT-2A silencing can inhibit breast cancer invasiveness. ..
  4. Kayaalti Z, Aliyev V, Soylemezoglu T. The potential effect of metallothionein 2A -5A/G single nucleotide polymorphism on blood cadmium, lead, zinc and copper levels. Toxicol Appl Pharmacol. 2011;256:1-7 pubmed publisher
    ..The aim of this study was to investigate the association between the metallothionein 2A (MT2A) core promoter region -5 A/G single nucleotide polymorphism (SNP) and Cd, Pb, Zn and Cu levels in the blood samples...
  5. Pan Y, Huang J, Xing R, Yin X, Cui J, Li W, et al. Metallothionein 2A inhibits NF-?B pathway activation and predicts clinical outcome segregated with TNM stage in gastric cancer patients following radical resection. J Transl Med. 2013;11:173 pubmed publisher
    Metallothionein 2A (MT2A) as a stress protein, plays a protective role in gastric mucosal barrier. Its role in the development of gastric cancer (GC) is unclear. The mechanism of MT2A will be investigated in gastric tumorigenesis...
  6. Panossian A, Seo E, Efferth T. Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. Phytomedicine. 2018;50:257-284 pubmed publisher
    ..tested activated the melatonin signaling pathway by acting through two G-protein-coupled membrane receptors MT1 and MT2 and upregulation of the ligand-specific nuclear receptor RORA, which plays a role in intellectual disability, ..
  7. Luo C, Yang Q, Liu Y, Zhou S, Jiang J, Reiter R, et al. The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health. Free Radic Biol Med. 2019;130:215-233 pubmed publisher
    ..We analyze the involvement of melatonin receptor 1A (MT1), melatonin receptor 1B (MT2), and melatonin receptor 1C (MT3) in the protection of melatonin and/or NAS...
  8. Buapet P, Mohammadi N, Pernice M, Kumar M, Kuzhiumparambil U, Ralph P. Excess copper promotes photoinhibition and modulates the expression of antioxidant-related genes in Zostera muelleri. Aquat Toxicol. 2019;207:91-100 pubmed publisher any concentration failed to induce regulation in the expression level of genes encoding metallothionein type 2 (mt2), metallothionein type 3 (mt3) and cytochrome c oxidase copper chaperone (cox17)...
  9. Kozela E, Juknat A, Gao F, Kaushansky N, Coppola G, Vogel Z. Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells. J Neuroinflammation. 2016;13:136 pubmed publisher
    ..of oxidative stress modulators with potent anti-inflammatory activity that are controlled by Nfe2l2/Nrf2 (Mt1, Mt2a, Slc30a1, Hmox1)...
  10. Chen C, Xu C, Zhou T, Gao B, Zhou H, Chen C, et al. Abnormal osteogenic and chondrogenic differentiation of human mesenchymal stem cells from patients with adolescent idiopathic scoliosis in response to melatonin. Mol Med Rep. 2016;14:1201-9 pubmed publisher
    ..Compared with controls, MT2 demonstrated low expression in the AIS group...
  11. Zhou J, Wang D, Luo X, Jia X, Li M, Laudon M, et al. Melatonin Receptor Agonist Piromelatine Ameliorates Impaired Glucose Metabolism in Chronically Stressed Rats Fed a High-Fat Diet. J Pharmacol Exp Ther. 2018;364:55-69 pubmed publisher
    ..Piromelatine is a melatonin receptor-1/melatonin receptor-2 (MT1/MT2) agonist with high affinity for MLT receptors and a longer duration of action than MLT...
  12. Wang J, Jiang C, Zhang K, Lan X, Chen X, Zang W, et al. Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway. Free Radic Biol Med. 2019;131:345-355 pubmed publisher
    ..this study, using a weight-drop model of TBI, we investigated the protective effects of ramelteon, a melatonin MT1/MT2 receptor agonist, and its underlying mechanisms of action...
  13. Oliván S, Calvo A, Rando A, Herrando Grabulosa M, Manzano R, Zaragoza P, et al. Neuroprotective Effect of Non-viral Gene Therapy Treatment Based on Tetanus Toxin C-fragment in a Severe Mouse Model of Spinal Muscular Atrophy. Front Mol Neurosci. 2016;9:76 pubmed publisher
    ..Regarding the genes related to muscular atrophy (Ankrd1, Calm1, Col19a1, Fbox32, Mt2, Myod1, NogoA, Pax7, Rrad, and Sln), TTC suggest a compensatory effect for muscle damage response, diminished ..
  14. Righetti B, Mattos J, Siebert M, Daura Jorge F, Bezamat C, Fruet P, et al. Biochemical and molecular biomarkers in integument biopsies of free-ranging coastal bottlenose dolphins from southern Brazil. Chemosphere. 2019;225:139-149 pubmed publisher
    ..hydrocarbon receptor (AhR), AhR nuclear translocator (ARNT), cytochrome P450 1A1-like (CYP1A1), metallothionein 2A (MT2A), GST-π, GPx-4, GR, interleukin 1 alpha (IL-1α), and major histocompatibility complex II (MHCII) in the skin...
  15. Onphachanh X, Lee H, Lim J, Jung Y, Kim J, Chae C, et al. Enhancement of high glucose-induced PINK1 expression by melatonin stimulates neuronal cell survival: Involvement of MT2 /Akt/NF-κB pathway. J Pineal Res. 2017;63: pubmed publisher
    ..In conclusion, we have demonstrated the melatonin stimulates PINK1 expression via an MT2 /Akt/NF-κB pathway, and such stimulation is important for the prevention of neuronal cell apoptosis under high glucose conditions. ..
  16. Chriett S, Dąbek A, Wojtala M, Vidal H, Balcerczyk A, Pirola L. Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule. Sci Rep. 2019;9:742 pubmed publisher
    ..and fatty acid oxidation and R-β-hydroxybutyrate upregulating oxidative stress resistance factors FOXO3A and MT2 in mouse kidney...
  17. Espart A, Artime S, Tort Nasarre G, Yara Varón E. Cadmium exposure during pregnancy and lactation: materno-fetal and newborn repercussions of Cd(ii), and Cd-metallothionein complexes. Metallomics. 2018;10:1359-1367 pubmed publisher
    ..g. placenta, maternal blood, and mammary glands) induces the synthesis of MTs, preferably MT2, in an attempt to sequester the metal to avoid toxicity...
  18. Ullio C, Brunk U, Urani C, Melchioretto P, Bonelli G, Baccino F, et al. Autophagy of metallothioneins prevents TNF-induced oxidative stress and toxicity in hepatoma cells. Autophagy. 2015;11:2184-98 pubmed publisher
    ..TNF and CHX toxicity, while impairment of both autophagy and MT upregulation by silencing of Atg7, and Mt1a and/or Mt2a, respectively, abrogates protection...
  19. Chamanara M, Rashidian A, Mehr S, Dehpour A, Shirkohi R, Akbarian R, et al. Melatonin ameliorates TNBS-induced colitis in rats through the melatonin receptors: involvement of TLR4/MyD88/NF-κB signalling pathway. Inflammopharmacology. 2019;27:361-371 pubmed publisher
    ..p.) at doses of 1, 5, and 10 mg/kg/day. Luzindole (non-selective MT1/MT2 receptor antagonist) was administered i.p. at dose of 5 mg/kg/day 15 min prior to melatonin injection...
  20. Zhang S, Liu H, Amarsingh G, Cheung C, Hogl S, Narayanan U, et al. Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation. Cardiovasc Diabetol. 2014;13:100 pubmed publisher
    ..and increased polymerization of the copper-responsive transition-metal-binding metallothionein proteins (MT1/MT2), consistent with impaired anti-oxidant defences and elevated susceptibility to pro-oxidant stress...
  21. Wang X, Wu X, Liu Q, Kong G, Zhou J, Jiang J, et al. Ketogenic Metabolism Inhibits Histone Deacetylase (HDAC) and Reduces Oxidative Stress After Spinal Cord Injury in Rats. Neuroscience. 2017;366:36-43 pubmed publisher
    ..Anti-oxidative stress genes Foxo3a and Mt2 and related proteins, such as mitochondrial superoxide dismutase (SOD), FOXO3a, catalase were increased in dietary ..
  22. Leeboonngam T, Pramong R, Sae ung K, Govitrapong P, Phansuwan Pujito P. Neuroprotective effects of melatonin on amphetamine-induced dopaminergic fiber degeneration in the hippocampus of postnatal rats. J Pineal Res. 2017;: pubmed publisher
    ..signaling molecule, calcium/calmodulin-dependent protein kinase II (CaMKII), and the melatonin receptors (MT1 and MT2)...
  23. Yang W, Tang K, Wang Y, Zhang Y, Zan L. Melatonin promotes triacylglycerol accumulation via MT2 receptor during differentiation in bovine intramuscular preadipocytes. Sci Rep. 2017;7:15080 pubmed publisher
    ..status were reversed by treatment with luzindole, anantagonist of nonspecific melatonin receptors 1 (MT1) and 2 (MT2), and 4-phenyl-2-propionamidotetraline (4P-PDOT), a selective MT2 antagonist...
  24. Kadota Y, Toriuchi Y, Aki Y, Mizuno Y, Kawakami T, Nakaya T, et al. Metallothioneins regulate the adipogenic differentiation of 3T3-L1 cells via the insulin signaling pathway. PLoS ONE. 2017;12:e0176070 pubmed publisher
    ..We evaluated the fat pads of mice during the lactation stage. The fat mass and adipocyte size of MT1 and MT2 knockout mice were greater than those of wild type mice...
  25. Fisker K, Holmstrup M, Sørensen J. Freezing of body fluids induces metallothionein gene expression in earthworms (Dendrobaena octaedra). Comp Biochem Physiol C Toxicol Pharmacol. 2016;179:44-8 pubmed publisher
    ..would induce transcription of genes coding for heat shock proteins (hsp10 and hsp70), metallothioneins (mt1 and mt2), and glutathione-S-transferase (gst), and that the combined effects of these two stressors would be additive...
  26. Dorts J, Falisse E, Schoofs E, Flamion E, Kestemont P, Silvestre F. DNA methyltransferases and stress-related genes expression in zebrafish larvae after exposure to heat and copper during reprogramming of DNA methylation. Sci Rep. 2016;6:34254 pubmed publisher
    ..Finally, Cu exposure significantly increased the expression of metallothionein (mt2) and heat shock protein (hsp70), the latter being also increased following exposure to high temperature...
  27. Brun N, Wehrli B, Fent K. Ecotoxicological assessment of solar cell leachates: Copper indium gallium selenide (CIGS) cells show higher activity than organic photovoltaic (OPV) cells. Sci Total Environ. 2016;543:703-14 pubmed publisher
    ..alterations occurred in genes involved in oxidative stress (cat), hormonal activity (vtg1, ar), metallothionein (mt2), ER stress (bip, chop), and apoptosis (casp9)...
  28. Gupta S, Singh P, Sharma B, Sharma B. Neuroprotective Effects of Agomelatine and Vinpocetine Against Chronic Cerebral Hypoperfusion Induced Vascular Dementia. Curr Neurovasc Res. 2015;12:240-52 pubmed
    ..Aim of this study is to explore the role of agomelatine (a dual MT1 and MT2 melatonin receptor agonist) and vinpocetine (selective PDE1 inhibitor) in CCH induced vascular dementia (VaD)...
  29. Duerr G, Dewald D, Schmitz E, Verfuerth L, Keppel K, Peigney C, et al. Metallothioneins 1 and 2 Modulate Inflammation and Support Remodeling in Ischemic Cardiomyopathy in Mice. Mediators Inflamm. 2016;2016:7174127 pubmed publisher
    ..We investigated the role of zinc-donor proteins metallothionein MT1 and MT2 in a closed-chest murine model of I/R. Methods...
  30. Esteban Zubero E, López Pingarrón L, Alatorre Jiménez M, Ochoa Moneo P, Buisac Ramón C, Rivas Jiménez M, et al. Melatonin's role as a co-adjuvant treatment in colonic diseases: A review. Life Sci. 2017;170:72-81 pubmed publisher
    ..In the gastrointestinal tract, the activities of melatonin are mediated by melatonin receptors (MT2), serotonin (5-HT), and cholecystokinin B (CCK2) receptors and via receptor-independent processes...
  31. Yu X, Li S, Yang D, Qiu L, Wu Y, Wang D, et al. A novel strain of Lactobacillus mucosae isolated from a Gaotian villager improves in vitro and in vivo antioxidant as well as biological properties in D-galactose-induced aging mice. J Dairy Sci. 2016;99:903-914 pubmed publisher
    ..e., MT1A and MT1M in HT-29 and Caco-2) and those genes (i.e., MT1, MT2, GPx1, and GPx2) in the intestinal tract of the model mice...
  32. Qiu F, Liu X, Zhang Y, Wu Y, Xiao D, Shi L. Aerobic exercise enhanced endothelium-dependent vasorelaxation in mesenteric arteries in spontaneously hypertensive rats: the role of melatonin. Hypertens Res. 2018;41:718-729 pubmed publisher
    ..attenuated by the intraperitoneal administration of luzindole, a non-selective melatonin receptor (MT1/MT2) antagonist...
  33. Braga D, Barcella M, D Avila F, Lupoli S, Tagliaferri F, Santamaria M, et al. Preliminary profiling of blood transcriptome in a rat model of hemorrhagic shock. Exp Biol Med (Maywood). 2017;242:1462-1470 pubmed publisher
    ..modulation of genes related to inflammation and immune response (Tlr13, Il1b, Ccl6, Lgals3), antioxidant functions (Mt2A, Mt1), tissue injury and repair pathways (Gpnmb, Trim72) and lipid mediators (Alox5ap, Ltb4r, Ptger2) compared with ..
  34. Pechanova O, Paulis L, Simko F. Peripheral and central effects of melatonin on blood pressure regulation. Int J Mol Sci. 2014;15:17920-37 pubmed publisher
    ..Receptor-dependent effects are mediated predominantly through MT1 and MT2 G-protein coupled receptors...
  35. Zhao T, Zhang H, Jin C, Qiu F, Wu Y, Shi L. Melatonin mediates vasodilation through both direct and indirect activation of BKCa channels. J Mol Endocrinol. 2017;59:219-233 pubmed publisher
    ..of melatonin was significantly attenuated in the presence of BKCa channel blocker iberiotoxin or MT1/MT2 receptor antagonist luzindole in both (+) l-NAME and (-) l-NAME groups...
  36. Callegari I, Mattei C, Benassi F, Krueger F, Grafman J, Yaldizli O, et al. Agomelatine Improves Apathy in Frontotemporal Dementia. Neurodegener Dis. 2016;16:352-6 pubmed publisher
    ..variant of FTD, in order to determine the effectiveness on apathy of agomelatine, an antidepressant with MT1 and MT2 receptor agonism and 5-HT2C receptor antagonism; the latter leads to an increase in prefrontal dopaminergic and ..
  37. Karin M, Haslinger A, Heguy A, Dietlin T, Cooke T. Metal-responsive elements act as positive modulators of human metallothionein-IIA enhancer activity. Mol Cell Biol. 1987;7:606-13 pubmed
    ..Unlike deletion of the basal-level enhancer element, replacement of the GC box with linker DNA had no effect on the ability of the promoter to be induced by Cd2+. ..
  38. Leger D, Quera Salva M, Vecchierini M, Ogrizek P, Perry C, Dressman M. Safety profile of tasimelteon, a melatonin MT1 and MT2 receptor agonist: pooled safety analyses from six clinical studies. Expert Opin Drug Saf. 2015;14:1673-85 pubmed publisher
    ..Tasimelteon is a potent and specific melatonin (MT1 and MT2) receptor agonist with 2 - 4 times greater affinity for the MT2 receptor...
  39. Oishi A, Karamitri A, Gerbier R, Lahuna O, Ahmad R, Jockers R. Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions. Sci Rep. 2017;7:8990 pubmed publisher
    ..Collectively, these data show that GPR61, GPR62 and GPR135 are unable to bind melatonin, but show a reciprocal regulatory interaction with MT2 receptors. ..
  40. Jiang L, Vasak M, Vallee B, Maret W. Zinc transfer potentials of the alpha - and beta-clusters of metallothionein are affected by domain interactions in the whole molecule. Proc Natl Acad Sci U S A. 2000;97:2503-8 pubmed
    ..The two-domain structure of the whole molecule is important for its interaction with ligands and for control of its reactivity and overall conformation. ..
  41. Karotki A, Vasak M. Reaction of human metallothionein-3 with cisplatin and transplatin. J Biol Inorg Chem. 2009;14:1129-38 pubmed publisher
    ..The biological consequences of a substantially higher reactivity of cisplatin toward Zn7MT-3 than Zn7MT-2 in the acquired resistance to platinum-based drugs are discussed. ..
  42. Martinho A, Goncalves I, Cardoso I, Almeida M, Quintela T, Saraiva M, et al. Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin. FEBS J. 2010;277:3427-36 pubmed publisher
    Transthyretin (TTR), an amyloid-beta (Abeta) scavenger protein, and metallothioneins 2 and 3 (MT2 and MT3), low molecular weight metal-binding proteins, have recognized impacts in Abeta metabolism...
  43. Fan W, Cheng J, Zhang S, Liu X. Cloning and functions of the HBxAg-binding protein XBP1. Mol Med Rep. 2013;7:618-22 pubmed publisher
  44. Liang G, Lu S, Xu G, Liu X, Li J, Zhang D. Expression of metallothionein and Nrf2 pathway genes in lung cancer and cancer-surrounding tissues. World J Surg Oncol. 2013;11:199 pubmed publisher
    ..In surgical samples of lung cancer, MT expression was generally downregulated, whereas Nrf2 expression tended to be upregulated. These changes could play an integral role in lung carcinogenesis. ..
  45. Adams S, Barrick B, Christopher E, Shafer M, Makar K, Song X, et al. Genetic variation in metallothionein and metal-regulatory transcription factor 1 in relation to urinary cadmium, copper, and zinc. Toxicol Appl Pharmacol. 2015;289:381-8 pubmed publisher
    ..Minor alleles of rs28366003 and rs10636 near the MT2A gene were associated with lower urinary Cd, Cu, and Zn...
  46. Geva P, Kahta R, Nakonechny F, Aronov S, Nisnevitch M. Increased copper bioremediation ability of new transgenic and adapted Saccharomyces cerevisiae strains. Environ Sci Pollut Res Int. 2016;23:19613-25 pubmed publisher
    ..For this purpose, new strains of S. cerevisiae were produced by construction and integration of recombinant human MT2 and GFP-hMT2 genes into yeast cells...
  47. Zhou J, Zhang J, Luo X, Li M, Yue Y, Laudon M, et al. Neu-P11, a novel MT1/MT2 agonist, reverses diabetes by suppressing the hypothalamic-pituitary-adrenal axis in rats. Eur J Pharmacol. 2017;812:225-233 pubmed publisher
    ..The objective of the present study was to investigate the effect of the MT1/MT2 melatonin agonist Neu-P11 on glucose and lipid metabolism in T2DM rats induced by a high fat diet combined with low ..
  48. Fujiwara Y, Kitagawa T, Shinkai Y, Kaji T, Satoh M. [Cilostazol induces metallothionein expression in vascular cells]. Yakugaku Zasshi. 2009;129:1415-22 pubmed
    ..The present results suggest that cilostazol can protect the vascular system from toxic substances such as heavy metals via MT induction in vascular cells. ..
  49. Komatsubara M, Hara T, Hosoya T, Toma K, Tsukamoto Yamauchi N, Iwata N, et al. Melatonin regulates catecholamine biosynthesis by modulating bone morphogenetic protein and glucocorticoid actions. J Steroid Biochem Mol Biol. 2017;165:182-189 pubmed publisher
    ..The MT1 receptor, but not the MT2 receptor, was expressed in PC12 cells, and luzindole treatment reversed the inhibitory effect of melatonin on Th ..
  50. Re M, Gioacchini F, Bajraktari A, Tomasetti M, Kaleci S, Rubini C, et al. Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review. Eur Arch Otorhinolaryngol. 2017;274:2991-3000 pubmed publisher
    ..On the other hand, our review showed the paucity of studies investigating the molecular alterations which may be related with the malignant transformation of SNIP. ..
  51. Ng K, Leong M, Liang H, Paxinos G. Melatonin receptors: distribution in mammalian brain and their respective putative functions. Brain Struct Funct. 2017;222:2921-2939 pubmed publisher
    ..mapping, we may now understand better the localizations of the two G protein-coupled melatonin receptors MT1 and MT2. The abundance of these melatonin receptors in respective brain regions suggests that receptor-mediated actions of ..
  52. Gumulec J, Masarik M, Krizkova S, Hlavna M, Babula P, Hrabec R, et al. Evaluation of alpha-methylacyl-CoA racemase, metallothionein and prostate specific antigen as prostate cancer prognostic markers. Neoplasma. 2012;59:191-201 pubmed
    ..Alpha-methylacyl-CoA racemase (AMACR), metallothionein classes 1A and 2A (MT1A and MT2A) were determined and compared to prostate specific antigen (PSA) levels...
  53. Boran H, Boyle D, Altinok I, Patsiou D, Henry T. Aqueous Hg(2+) associates with TiO2 nanoparticles according to particle size, changes particle agglomeration, and becomes less bioavailable to zebrafish. Aquat Toxicol. 2016;174:242-6 pubmed publisher
    ..Here, gene [metallothionein 2 (mt2)] expression changes in larval zebrafish were used to evaluate the association between aqueous Hg(2+) ..
  54. Mehus A, Picklo M. Brain and Hepatic Mt mRNA Is Reduced in Response to Mild Energy Restriction and n-3 Polyunsaturated Fatty Acid Deficiency in Juvenile Rats. Nutrients. 2017;9: pubmed publisher
    ..Plasma corticosterone and triiodothyronine levels were also evaluated. ER, but not metal deficiency, reduced Mt2 expression in the cerebellum (50%) and cerebral cortex (23%)...
  55. Sekovanić A, Jurasovic J, Piasek M, Pasalic D, Orct T, Grgec A, et al. Metallothionein 2A gene polymorphism and trace elements in mother-newborn pairs in the Croatian population. J Trace Elem Med Biol. 2018;45:163-170 pubmed publisher
    ..blood, placenta, and cord blood (by ICP-MS), and MT2 levels in maternal serum (by ELISA) in relation to maternal MT2A -5A/G (rs28366003) polymorphism (by RFLP-PCR and electrophoresis)...
  56. Buendia I, Gómez Rangel V, González Lafuente L, Parada E, León R, Gameiro I, et al. Neuroprotective mechanism of the novel melatonin derivative Neu-P11 in brain ischemia related models. Neuropharmacology. 2015;99:187-95 pubmed publisher
    ..In this context, this study was planned to test the potential neuroprotective effects of the novel melatonin MT1/MT2 receptor agonist, Neu-P11, against brain ischemia in in vitro and in vivo models, and to elucidate its ..
  57. Canpolat S, Ulker N, Yardimci A, Bulmus O, Ozdemir G, Sahin Z, et al. Studies on the reproductive effects of chronic treatment with agomelatine in the rat. Eur J Pharmacol. 2016;770:33-9 pubmed publisher
    Agomelatine is an antidepressant with a novel mechanism of action. It is a melatonergic agonist for MT1 and MT2 receptors and a serotonin (5-HT2C) receptor antagonist...
  58. Gundacker C, Wittmann K, Kukuckova M, Komarnicki G, Hikkel I, Gencik M. Genetic background of lead and mercury metabolism in a group of medical students in Austria. Environ Res. 2009;109:786-96 pubmed publisher
    ..We found evidence that certain genetic backgrounds were associated with lead and mercury metabolism, suggesting gene-environment and gene-gene-environment interactions. The modes of interaction remain to be evaluated. ..
  59. Hu Y, Chen J, Wang B, Yang W, Zhang C, Hu J, et al. Engineering a peptide inhibitor towards the KCNQ1/KCNE1 potassium channel (IKs). Peptides. 2015;71:77-83 pubmed publisher
    ..Pharmacological experiments showed that when we screen with 1μM MT2 peptide, an analog derived from BmKTX toxin, KCNQ1/KCNE1 channel currents could be effectively inhibited...
  60. Reinecke F, Levanets O, Olivier Y, Louw R, Semete B, Grobler A, et al. Metallothionein isoform 2A expression is inducible and protects against ROS-mediated cell death in rotenone-treated HeLa cells. Biochem J. 2006;395:405-15 pubmed
    ..Expression of MT2A (MT isoform 2A), but not MT1A or MT1B RNA, was significantly inducible by rotenone (up to 7-fold), t-BHP (t-butyl ..
  61. Yamasaki M, Nomura T, Sato F, Mimata H. Metallothionein is up-regulated under hypoxia and promotes the survival of human prostate cancer cells. Oncol Rep. 2007;18:1145-53 pubmed
    ..As down-regulation of MT by siRNA inhibited cell growth and induced cell death, MT may be a new molecular target for the treatment of human prostate cancer. ..
  62. Puła B, Strutyńska Karpińska M, Markowska Woyciechowska A, Jethon A, Wołowiec D, Rys J, et al. Expression of metallothionein and Ki-67 antigen in GISTs of different grade of malignancy. Adv Clin Exp Med. 2013;22:513-8 pubmed
    ..01). MT-I/II and Ki-67 expression positively correlated in GISTBs (r = 0.48, p = 0.0463), but not in GISTMs. The results of this study may point to a potential role of MT-I/II in the proliferation of GIST cells and disease progression. ..
  63. Juszczak M, Wolak M, Bojanowska E, Piera L, Roszczyk M. The role of melatonin membrane receptors in melatonin-dependent oxytocin secretion from the rat hypothalamo-neurohypophysial system - an in vitro and in vivo approach. Endokrynol Pol. 2016;67:507-514 pubmed publisher
    Melatonin exerts its biological role acting mainly via G protein-coupled membrane MT1 and MT2 receptors...
  64. Wu M, Li W, Dick W, Ye X, Chen K, Kost D, et al. Bioremediation of hydrocarbon degradation in a petroleum-contaminated soil and microbial population and activity determination. Chemosphere. 2017;169:124-130 pubmed publisher
    ..number (MPN) procedure, and the hydrocarbon degrading activities of these degraders were determined by the Biolog (MT2) MicroPlates assay...
  65. Tian X, Wang F, Zhang L, He C, Ji P, Wang J, et al. Beneficial Effects of Melatonin on the In Vitro Maturation of Sheep Oocytes and Its Relation to Melatonin Receptors. Int J Mol Sci. 2017;18: pubmed publisher
    ..Melatonin receptors (MT1 and MT2) were evaluated via immunofluorescence and Western blot...
  66. Haimovich G, Ecker C, Dunagin M, Eggan E, Raj A, Gerst J, et al. Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells. Proc Natl Acad Sci U S A. 2017;114:E9873-E9882 pubmed publisher
    ..Examples of mRNAs that undergo transfer include those encoding GFP, mouse ?-actin, and human Cyclin D1, BRCA1, MT2A, and HER2. We show that intercellular mRNA transfer occurs in all coculture models tested (e.g...
  67. Underbayev C, Kasar S, Ruezinsky W, Degheidy H, Schneider J, Marti G, et al. Role of mir-15a/16-1 in early B cell development in a mouse model of chronic lymphocytic leukemia. Oncotarget. 2016;7:60986-60999 pubmed publisher
    ..delivered miR-15a into the NZB derived B cell line provided valuable clues into novel targets such as Mmp10 and Mt2. Our data supports the hypothesis that miR-15a/16 deficient stem cells and B1Ps experience a maturation blockage, ..
  68. Aballay E, Prodan S, Zamorano A, Castaneda Alvarez C. Nematicidal effect of rhizobacteria on plant-parasitic nematodes associated with vineyards. World J Microbiol Biotechnol. 2017;33:131 pubmed publisher
    ..While chitinase and collagenase were measured using the BIOLOG MT2 plate system, protease, hydrogen cyanide and hydrogen sulphide were directly determined in Petri dishes...
  69. Sadowski C, Kohlstedt D, Meisel C, Keller K, Becker K, Mackenroth L, et al. BRCA1/2 missense mutations and the value of in-silico analyses. Eur J Med Genet. 2017;60:572-577 pubmed publisher
    ..all missense variants were classified by the following three in-silico prediction tools: SIFT, Mutation Taster (MT2) and PolyPhen2 (PPH2)...
  70. Kayaalti Z, Sahiner L, Durakoğlugil M, Soylemezoglu T. Distributions of interleukin-6 (IL-6) promoter and metallothionein 2A (MT2A) core promoter region gene polymorphisms and their associations with aging in Turkish population. Arch Gerontol Geriatr. 2011;53:354-8 pubmed publisher
    ..The aim of this study was to investigate the association between the IL-6 -174 G/C promoter region and MT2A -5 A/G core promoter region single nucleotide polymorphisms (SNPs) with longevity in Turkish population...
  71. Velic A, Laturnus D, Chhoun J, Zheng S, Epstein P, CARLSON E. Diabetic basement membrane thickening does not occur in myocardial capillaries of transgenic mice when metallothionein is overexpressed in cardiac myocytes. Anat Rec (Hoboken). 2013;296:480-7 pubmed publisher
    ..In addition, the reduction of intra- and perivascular ROS may protect against incipient endothelial damage and the CBM thickening that results from such injury. ..
  72. Starska K, BryÅ› M, Forma E, Olszewski J, Pietkiewicz P, Lewy Trenda I, et al. The effect of metallothionein 2A core promoter region single-nucleotide polymorphism on accumulation of toxic metals in sinonasal inverted papilloma tissues. Toxicol Appl Pharmacol. 2015;285:187-97 pubmed publisher
    ..was to identify the -5 A/G (rs28366003) single-nucleotide polymorphism (SNP) in the core promoter region of the MT2A gene, and to investigate its effect on allele-specific gene expression and Cd, Zn, Cu and Ni content in sinonasal ..
  73. Pietrucha Dutczak M, Smedowski A, Liu X, Matuszek I, Varjosalo M, Lewin Kowalik J. Candidate proteins from predegenerated nerve exert time-specific protection of retinal ganglion cells in glaucoma. Sci Rep. 2017;7:14540 pubmed publisher
    ..Mass Spectrometry analysis demonstrated that metallothionein 2 (MT2) may be a key molecule responsible for neuroprotective effects on RGC survival.
  74. Sun X, Kang Y. Prior increase in metallothionein levels is required to prevent doxorubicin cardiotoxicity. Exp Biol Med (Maywood). 2002;227:652-7 pubmed
    ..However, MT can protect the heart from oxidative injury only if it is present prior to induction of oxidative stress. ..
  75. Nemec A, Leikauf G, Pitt B, Wasserloos K, Barchowsky A. Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells. Am J Respir Cell Mol Biol. 2009;41:69-75 pubmed publisher
    ..Ni to mobilize zinc (Zn) may contribute to such regulation and therefore, we examined the mechanism for Ni-induced MT2A expression in human airway epithelial (BEAS-2B) cells...
  76. Haynes V, Connor T, Tchernof A, Vidal H, Dubois S. Metallothionein 2a gene expression is increased in subcutaneous adipose tissue of type 2 diabetic patients. Mol Genet Metab. 2013;108:90-4 pubmed publisher
    ..Metallothioneins (Mts) are a family of anti-oxidant proteins and metallothionein 2a (Mt2a) polymorphims have been recently associated with type 2 diabetes and related complications...
  77. Krzeslak A, Forma E, Chwatko G, Jóźwiak P, Szymczyk A, Wilkosz J, et al. Effect of metallothionein 2A gene polymorphism on allele-specific gene expression and metal content in prostate cancer. Toxicol Appl Pharmacol. 2013;268:278-85 pubmed publisher
    ..A/G single nucleotide polymorphism (SNP; rs28366003) in core promoter region and expression of metallothionein 2A (MT2A) gene and metal concentration in prostate cancer tissues...
  78. Pan Y, Lin S, Xing R, Zhu M, Lin B, Cui J, et al. Epigenetic Upregulation of Metallothionein 2A by Diallyl Trisulfide Enhances Chemosensitivity of Human Gastric Cancer Cells to Docetaxel Through Attenuating NF-κB Activation. Antioxid Redox Signal. 2016;24:839-54 pubmed publisher
    Metallothionein 2A (MT2A) and nuclear factor-kappaB (NF-κB) are both involved in carcinogenesis and cancer chemosensitivity...
  79. Raudenska M, Dvorakova V, Pácal L, Chalasova K, Kratochvilova M, Gumulec J, et al. Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease. J Biochem Mol Toxicol. 2017;31: pubmed publisher
    ..Ascertained differences indicate increased oxidative stress in T2DM accompanied by abnormalities in non-enzymatic antioxidant defense systems. ..
  80. Yang C, Chuang C, Lin C, Wang C, Huang Y, Chuang H. The association of the blood lead level and serum lipid concentrations may be modified by the genetic combination of the metallothionein 2A polymorphisms rs10636 GC and rs28366003 AA. J Clin Lipidol. 2017;11:234-241 pubmed publisher
    ..One of the most expressive functional genes in humans is the MT2A gene...
  81. Barrera M, Rojas L, Weiss A, Fernández O, MCMAHON PRATT D, Saravia N, et al. Profiling gene expression of antimony response genes in Leishmania (Viannia) panamensis and infected macrophages and its relationship with drug susceptibility. Acta Trop. 2017;176:355-363 pubmed publisher
    ..V.) panamensis lines. Four molecules, abcb1 (p-gp), abcb6, aqp-9 and mt2a were differentially modulated by drug resistant and susceptible parasites, and among these, a consistent and ..
  82. Cavalier Smith T. Euglenoid pellicle morphogenesis and evolution in light of comparative ultrastructure and trypanosomatid biology: Semi-conservative microtubule/strip duplication, strip shaping and transformation. Eur J Protistol. 2017;61:137-179 pubmed publisher
    ..At strip heel/toe junctions all euglenoids have a morphogenetic centre microtubule mt2/3 pair...
  83. Duroux R, Rami M, Landagaray E, Ettaoussi M, Caignard D, Delagrange P, et al. Synthesis and biological evaluation of new naphtho- and quinolinocyclopentane derivatives as potent melatoninergic (MT1/MT2) and serotoninergic (5-HT2C) dual ligands. Eur J Med Chem. 2017;141:552-566 pubmed publisher
    ..Enantiomeric separation was then performed on selected compounds allowing us to identify levogyre enantiomers (-)-17g and (-)-17k as the highest (MT1, MT2)/5-HT2C dual ligands described nowadays...
  84. Costello L, Guan Z, Franklin R, Feng P. Metallothionein can function as a chaperone for zinc uptake transport into prostate and liver mitochondria. J Inorg Biochem. 2004;98:664-6 pubmed
    ..However, in liver and perhaps other cells, Zn(7)-MT is probably important in the cytosolic trafficking of zinc to the mitochondria for the uptake of zinc into the mitochondrial matrix by the putative zinc uptake transporter. ..
  85. Liang Z, Yang Z. Identification and characterization of a novel gene EOLA1 stimulating ECV304 cell proliferation. Biochem Biophys Res Commun. 2004;325:798-802 pubmed bait, we performed a yeast two-hybrid screening of a human liver cDNA library and identified metallothionein 2A (MT2A) as associated protein. Stable transfection of EOLA1 stimulates ECV304 cell proliferation...
  86. Liang Z, Yang Z, Liu Y, Chen Y, Luo X. [Identification and characterization of a novel gene EOLA1 stimulating ECV304 cell proliferation]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22:518-23 pubmed bait, we performed a yeast two-hybrid screening of a human liver cDNA library and identified metallothionein 2A (MT2A) as associated protein. The interaction between EOLA1 and MT2A was confirmed by co-immunoprecipitation experiments...
  87. Faurschou M, Penkowa M, Andersen C, Starklint H, Jacobsen S. The renal metallothionein expression profile is altered in human lupus nephritis. Arthritis Res Ther. 2008;10:R76 pubmed publisher
    ..Our data indicate that important prognostic information can be deduced from the renal MT-I+II expression profile in systemic lupus erythematosus patients with nephritis. ..
  88. Pedersen M, Hansen P, Nielsen S, Penkowa M. Metallothionein-I + II and receptor megalin are altered in relation to oxidative stress in cerebral lymphomas. Leuk Lymphoma. 2010;51:314-28 pubmed publisher
    ..This morphology likely reflects the CNS lymphoma microenvironment and molecular interactions between lymphomatous and neuronal cells. ..
  89. Fernandes K, Martins A, Oliveira A, Antunes L, Cólus I, Barbosa F, et al. Polymorphism of Metallothionein 2A Modifies Lead Body Burden in Workers Chronically Exposed to the Metal. Public Health Genomics. 2016;19:47-52 pubmed publisher
    ..The present study aimed to evaluate the genetic effects of the polymorphism of MT2A (single nucleotide polymorphism rs10636; Cx2192;G) on blood Pb levels (BLL) of workers from car battery factories ..
  90. Liu D, Wang M, Tian T, Wang X, Kang H, Jin T, et al. Genetic polymorphisms (rs10636 and rs28366003) in metallothionein 2A increase breast cancer risk in Chinese Han population. Aging (Albany NY). 2017;9:547-555 pubmed publisher
    Genetic polymorphisms of MT2A are frequently observed in many different cancers...
  91. Mocchegiani E, Muzzioli M, Giacconi R, Cipriano C, Gasparini N, Franceschi C, et al. Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply. Mech Ageing Dev. 2003;124:459-68 pubmed
    ..Therefore, the zinc ion bioavailability by zinc-bound MTs homeostasis is pivotal to reach health longevity and successful ageing. ..
  92. Hayashi Y, Hashizume T, Wakida K, Satoh M, Uchida Y, Watabe K, et al. Association between metallothionein genes polymorphisms and sporadic amyotrophic lateral sclerosis in a Japanese population. Amyotroph Lateral Scler. 2006;7:22-6 pubmed
    ..We conclude that gene polymorphisms of MT-IIA promoter region and MT-III gene are not associated with SALS phenotypes in a Japanese population. ..